-- dump date 20140619_095426 -- class Genbank::misc_feature -- table misc_feature_note -- id note 441952000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 441952000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441952000003 Walker A motif; other site 441952000004 ATP binding site [chemical binding]; other site 441952000005 Walker B motif; other site 441952000006 arginine finger; other site 441952000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 441952000008 DnaA box-binding interface [nucleotide binding]; other site 441952000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 441952000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 441952000011 putative DNA binding surface [nucleotide binding]; other site 441952000012 dimer interface [polypeptide binding]; other site 441952000013 beta-clamp/clamp loader binding surface; other site 441952000014 beta-clamp/translesion DNA polymerase binding surface; other site 441952000015 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 441952000016 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 441952000017 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 441952000018 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 441952000019 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 441952000020 NAD binding site [chemical binding]; other site 441952000021 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 441952000022 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 441952000023 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 441952000024 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 441952000025 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 441952000026 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 441952000027 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 441952000028 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 441952000029 ATP-grasp domain; Region: ATP-grasp_4; cl17255 441952000030 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 441952000031 substrate binding site [chemical binding]; other site 441952000032 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 441952000033 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 441952000034 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 441952000035 catalytic site [active] 441952000036 subunit interface [polypeptide binding]; other site 441952000037 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 441952000038 catalytic core [active] 441952000039 thiopurine S-methyltransferase; Reviewed; Region: PRK13256 441952000040 dihydroorotase; Reviewed; Region: PRK09236 441952000041 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 441952000042 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 441952000043 active site 441952000044 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 441952000045 HlyD family secretion protein; Region: HlyD; pfam00529 441952000046 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 441952000047 HlyD family secretion protein; Region: HlyD_3; pfam13437 441952000048 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 441952000049 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441952000050 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441952000051 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 441952000052 dimerization interface [polypeptide binding]; other site 441952000053 SOUL heme-binding protein; Region: SOUL; pfam04832 441952000054 Chorismate mutase type II; Region: CM_2; smart00830 441952000055 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 441952000056 active site 441952000057 dimer interface [polypeptide binding]; other site 441952000058 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 441952000059 phosphate binding site [ion binding]; other site 441952000060 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 441952000061 putative active site [active] 441952000062 dimerization interface [polypeptide binding]; other site 441952000063 putative tRNAtyr binding site [nucleotide binding]; other site 441952000064 Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251 441952000065 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 441952000066 substrate binding [chemical binding]; other site 441952000067 active site 441952000068 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 441952000069 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 441952000070 putative FMN binding site [chemical binding]; other site 441952000071 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 441952000072 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 441952000073 aromatic amino acid transport protein; Region: araaP; TIGR00837 441952000074 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 441952000075 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 441952000076 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 441952000077 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 441952000078 catalytic residue [active] 441952000079 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 441952000080 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441952000081 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441952000082 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 441952000083 putative effector binding pocket; other site 441952000084 dimerization interface [polypeptide binding]; other site 441952000085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952000086 putative substrate translocation pore; other site 441952000087 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 441952000088 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 441952000089 dimer interface [polypeptide binding]; other site 441952000090 active site 441952000091 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 441952000092 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 441952000093 GTP-binding protein LepA; Provisional; Region: PRK05433 441952000094 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 441952000095 G1 box; other site 441952000096 putative GEF interaction site [polypeptide binding]; other site 441952000097 GTP/Mg2+ binding site [chemical binding]; other site 441952000098 Switch I region; other site 441952000099 G2 box; other site 441952000100 G3 box; other site 441952000101 Switch II region; other site 441952000102 G4 box; other site 441952000103 G5 box; other site 441952000104 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 441952000105 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 441952000106 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 441952000107 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 441952000108 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 441952000109 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 441952000110 active site 441952000111 catalytic residues [active] 441952000112 metal binding site [ion binding]; metal-binding site 441952000113 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 441952000114 homopentamer interface [polypeptide binding]; other site 441952000115 active site 441952000116 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 441952000117 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 441952000118 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 441952000119 dimerization interface [polypeptide binding]; other site 441952000120 active site 441952000121 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 441952000122 Lumazine binding domain; Region: Lum_binding; pfam00677 441952000123 Lumazine binding domain; Region: Lum_binding; pfam00677 441952000124 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 441952000125 catalytic motif [active] 441952000126 Zn binding site [ion binding]; other site 441952000127 RibD C-terminal domain; Region: RibD_C; pfam01872 441952000128 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 441952000129 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 441952000130 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 441952000131 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 441952000132 Cl- selectivity filter; other site 441952000133 Cl- binding residues [ion binding]; other site 441952000134 pore gating glutamate residue; other site 441952000135 dimer interface [polypeptide binding]; other site 441952000136 H+/Cl- coupling transport residue; other site 441952000137 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 441952000138 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 441952000139 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441952000140 catalytic residue [active] 441952000141 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 441952000142 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 441952000143 substrate binding site [chemical binding]; other site 441952000144 active site 441952000145 catalytic residues [active] 441952000146 heterodimer interface [polypeptide binding]; other site 441952000147 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 441952000148 Clp amino terminal domain; Region: Clp_N; pfam02861 441952000149 Clp amino terminal domain; Region: Clp_N; pfam02861 441952000150 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441952000151 Walker A motif; other site 441952000152 ATP binding site [chemical binding]; other site 441952000153 Walker B motif; other site 441952000154 arginine finger; other site 441952000155 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441952000156 Walker A motif; other site 441952000157 ATP binding site [chemical binding]; other site 441952000158 Walker B motif; other site 441952000159 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 441952000160 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 441952000161 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 441952000162 active site 441952000163 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 441952000164 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 441952000165 ATP-grasp domain; Region: ATP-grasp; pfam02222 441952000166 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 441952000167 4Fe-4S binding domain; Region: Fer4; cl02805 441952000168 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 441952000169 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 441952000170 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 441952000171 putative acyl-acceptor binding pocket; other site 441952000172 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 441952000173 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 441952000174 putative acyl-acceptor binding pocket; other site 441952000175 hypothetical protein; Provisional; Region: PRK05421 441952000176 putative catalytic site [active] 441952000177 putative metal binding site [ion binding]; other site 441952000178 putative phosphate binding site [ion binding]; other site 441952000179 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14854 441952000180 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 441952000181 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 441952000182 [2Fe-2S] cluster binding site [ion binding]; other site 441952000183 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 441952000184 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 441952000185 active site 441952000186 catalytic residues [active] 441952000187 adenylosuccinate lyase; Provisional; Region: PRK07492 441952000188 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 441952000189 tetramer interface [polypeptide binding]; other site 441952000190 active site 441952000191 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 441952000192 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 441952000193 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 441952000194 HlyD family secretion protein; Region: HlyD_3; pfam13437 441952000195 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 441952000196 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 441952000197 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 441952000198 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 441952000199 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 441952000200 GatB domain; Region: GatB_Yqey; smart00845 441952000201 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 441952000202 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952000203 putative substrate translocation pore; other site 441952000204 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 441952000205 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme MccE; Region: PLPDE_III_MccE_like; cd06841 441952000206 dimer interface [polypeptide binding]; other site 441952000207 active site 441952000208 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 441952000209 catalytic residues [active] 441952000210 substrate binding site [chemical binding]; other site 441952000211 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441952000212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952000213 IucA / IucC family; Region: IucA_IucC; pfam04183 441952000214 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 441952000215 ferric uptake regulator; Provisional; Region: fur; PRK09462 441952000216 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 441952000217 metal binding site 2 [ion binding]; metal-binding site 441952000218 putative DNA binding helix; other site 441952000219 metal binding site 1 [ion binding]; metal-binding site 441952000220 dimer interface [polypeptide binding]; other site 441952000221 structural Zn2+ binding site [ion binding]; other site 441952000222 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 441952000223 NADH dehydrogenase subunit B; Validated; Region: PRK06411 441952000224 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 441952000225 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 441952000226 NADH dehydrogenase subunit D; Validated; Region: PRK06075 441952000227 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 441952000228 NADH dehydrogenase subunit E; Validated; Region: PRK07539 441952000229 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 441952000230 putative dimer interface [polypeptide binding]; other site 441952000231 [2Fe-2S] cluster binding site [ion binding]; other site 441952000232 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 441952000233 SLBB domain; Region: SLBB; pfam10531 441952000234 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 441952000235 NADH dehydrogenase subunit G; Validated; Region: PRK09129 441952000236 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 441952000237 catalytic loop [active] 441952000238 iron binding site [ion binding]; other site 441952000239 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 441952000240 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 441952000241 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 441952000242 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 441952000243 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 441952000244 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 441952000245 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 441952000246 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 441952000247 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 441952000248 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 441952000249 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 441952000250 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 441952000251 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 441952000252 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 441952000253 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 441952000254 Membrane fusogenic activity; Region: BMFP; pfam04380 441952000255 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 441952000256 substrate binding site [chemical binding]; other site 441952000257 active site 441952000258 ribosome maturation protein RimP; Reviewed; Region: PRK00092 441952000259 hypothetical protein; Provisional; Region: PRK14641 441952000260 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 441952000261 putative oligomer interface [polypeptide binding]; other site 441952000262 putative RNA binding site [nucleotide binding]; other site 441952000263 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 441952000264 NusA N-terminal domain; Region: NusA_N; pfam08529 441952000265 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 441952000266 RNA binding site [nucleotide binding]; other site 441952000267 homodimer interface [polypeptide binding]; other site 441952000268 NusA-like KH domain; Region: KH_5; pfam13184 441952000269 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 441952000270 G-X-X-G motif; other site 441952000271 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 441952000272 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 441952000273 translation initiation factor IF-2; Region: IF-2; TIGR00487 441952000274 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 441952000275 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 441952000276 G1 box; other site 441952000277 putative GEF interaction site [polypeptide binding]; other site 441952000278 GTP/Mg2+ binding site [chemical binding]; other site 441952000279 Switch I region; other site 441952000280 G2 box; other site 441952000281 G3 box; other site 441952000282 Switch II region; other site 441952000283 G4 box; other site 441952000284 G5 box; other site 441952000285 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 441952000286 Translation-initiation factor 2; Region: IF-2; pfam11987 441952000287 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 441952000288 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 441952000289 histidyl-tRNA synthetase; Region: hisS; TIGR00442 441952000290 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 441952000291 dimer interface [polypeptide binding]; other site 441952000292 motif 1; other site 441952000293 active site 441952000294 motif 2; other site 441952000295 motif 3; other site 441952000296 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 441952000297 anticodon binding site; other site 441952000298 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952000299 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 441952000300 putative substrate translocation pore; other site 441952000301 Predicted ATPase [General function prediction only]; Region: COG1485 441952000302 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 441952000303 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441952000304 RNA binding surface [nucleotide binding]; other site 441952000305 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 441952000306 active site 441952000307 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441952000308 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952000309 putative substrate translocation pore; other site 441952000310 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 441952000311 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 441952000312 F0F1 ATP synthase subunit C; Provisional; Region: PRK13464 441952000313 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 441952000314 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 441952000315 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 441952000316 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 441952000317 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 441952000318 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 441952000319 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 441952000320 beta subunit interaction interface [polypeptide binding]; other site 441952000321 Walker A motif; other site 441952000322 ATP binding site [chemical binding]; other site 441952000323 Walker B motif; other site 441952000324 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 441952000325 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 441952000326 core domain interface [polypeptide binding]; other site 441952000327 delta subunit interface [polypeptide binding]; other site 441952000328 epsilon subunit interface [polypeptide binding]; other site 441952000329 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 441952000330 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 441952000331 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 441952000332 alpha subunit interaction interface [polypeptide binding]; other site 441952000333 Walker A motif; other site 441952000334 ATP binding site [chemical binding]; other site 441952000335 Walker B motif; other site 441952000336 inhibitor binding site; inhibition site 441952000337 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 441952000338 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13452 441952000339 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 441952000340 gamma subunit interface [polypeptide binding]; other site 441952000341 epsilon subunit interface [polypeptide binding]; other site 441952000342 LBP interface [polypeptide binding]; other site 441952000343 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 441952000344 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 441952000345 putative active site [active] 441952000346 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 441952000347 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 441952000348 putative GSH binding site [chemical binding]; other site 441952000349 catalytic residues [active] 441952000350 superoxide dismutase; Provisional; Region: PRK10543 441952000351 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 441952000352 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 441952000353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952000354 muropeptide transporter; Reviewed; Region: ampG; PRK11902 441952000355 putative substrate translocation pore; other site 441952000356 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 441952000357 dimer interface [polypeptide binding]; other site 441952000358 Citrate synthase; Region: Citrate_synt; pfam00285 441952000359 active site 441952000360 citrylCoA binding site [chemical binding]; other site 441952000361 NADH binding [chemical binding]; other site 441952000362 cationic pore residues; other site 441952000363 oxalacetate/citrate binding site [chemical binding]; other site 441952000364 coenzyme A binding site [chemical binding]; other site 441952000365 catalytic triad [active] 441952000366 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 441952000367 Iron-sulfur protein interface; other site 441952000368 proximal quinone binding site [chemical binding]; other site 441952000369 SdhD (CybS) interface [polypeptide binding]; other site 441952000370 proximal heme binding site [chemical binding]; other site 441952000371 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 441952000372 SdhC subunit interface [polypeptide binding]; other site 441952000373 proximal heme binding site [chemical binding]; other site 441952000374 cardiolipin binding site; other site 441952000375 Iron-sulfur protein interface; other site 441952000376 proximal quinone binding site [chemical binding]; other site 441952000377 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 441952000378 L-aspartate oxidase; Provisional; Region: PRK06175 441952000379 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 441952000380 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 441952000381 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 441952000382 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 441952000383 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 441952000384 TPP-binding site [chemical binding]; other site 441952000385 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 441952000386 dimer interface [polypeptide binding]; other site 441952000387 PYR/PP interface [polypeptide binding]; other site 441952000388 TPP binding site [chemical binding]; other site 441952000389 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 441952000390 E3 interaction surface; other site 441952000391 lipoyl attachment site [posttranslational modification]; other site 441952000392 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 441952000393 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 441952000394 E3 interaction surface; other site 441952000395 lipoyl attachment site [posttranslational modification]; other site 441952000396 e3 binding domain; Region: E3_binding; pfam02817 441952000397 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 441952000398 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 441952000399 nucleotide binding site [chemical binding]; other site 441952000400 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441952000401 active site 441952000402 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14320 441952000403 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 441952000404 active site 441952000405 substrate binding site [chemical binding]; other site 441952000406 metal binding site [ion binding]; metal-binding site 441952000407 triosephosphate isomerase; Provisional; Region: PRK14567 441952000408 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 441952000409 substrate binding site [chemical binding]; other site 441952000410 dimer interface [polypeptide binding]; other site 441952000411 catalytic triad [active] 441952000412 Preprotein translocase SecG subunit; Region: SecG; pfam03840 441952000413 HemN family oxidoreductase; Provisional; Region: PRK05660 441952000414 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441952000415 FeS/SAM binding site; other site 441952000416 HemN C-terminal domain; Region: HemN_C; pfam06969 441952000417 Predicted membrane protein [Function unknown]; Region: COG2246 441952000418 GtrA-like protein; Region: GtrA; pfam04138 441952000419 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 441952000420 aconitate hydratase; Validated; Region: PRK09277 441952000421 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 441952000422 substrate binding site [chemical binding]; other site 441952000423 ligand binding site [chemical binding]; other site 441952000424 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 441952000425 substrate binding site [chemical binding]; other site 441952000426 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 441952000427 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952000428 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 441952000429 NAD(P) binding site [chemical binding]; other site 441952000430 active site 441952000431 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441952000432 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441952000433 dimer interface [polypeptide binding]; other site 441952000434 phosphorylation site [posttranslational modification] 441952000435 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441952000436 ATP binding site [chemical binding]; other site 441952000437 Mg2+ binding site [ion binding]; other site 441952000438 G-X-G motif; other site 441952000439 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 441952000440 dimer interface [polypeptide binding]; other site 441952000441 catalytic triad [active] 441952000442 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952000443 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 441952000444 putative substrate translocation pore; other site 441952000445 multidrug efflux protein; Reviewed; Region: PRK09579 441952000446 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 441952000447 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 441952000448 HlyD family secretion protein; Region: HlyD_3; pfam13437 441952000449 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 441952000450 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13296 441952000451 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 441952000452 active site 441952000453 NTP binding site [chemical binding]; other site 441952000454 metal binding triad [ion binding]; metal-binding site 441952000455 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 441952000456 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 441952000457 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441952000458 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 441952000459 Walker A/P-loop; other site 441952000460 ATP binding site [chemical binding]; other site 441952000461 Q-loop/lid; other site 441952000462 ABC transporter signature motif; other site 441952000463 Walker B; other site 441952000464 D-loop; other site 441952000465 H-loop/switch region; other site 441952000466 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 441952000467 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 441952000468 DNA polymerase I; Provisional; Region: PRK05755 441952000469 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 441952000470 active site 441952000471 metal binding site 1 [ion binding]; metal-binding site 441952000472 putative 5' ssDNA interaction site; other site 441952000473 metal binding site 3; metal-binding site 441952000474 metal binding site 2 [ion binding]; metal-binding site 441952000475 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 441952000476 putative DNA binding site [nucleotide binding]; other site 441952000477 putative metal binding site [ion binding]; other site 441952000478 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 441952000479 active site 441952000480 catalytic site [active] 441952000481 substrate binding site [chemical binding]; other site 441952000482 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 441952000483 active site 441952000484 DNA binding site [nucleotide binding] 441952000485 catalytic site [active] 441952000486 pantothenate kinase; Reviewed; Region: PRK13324 441952000487 phosphopentomutase; Provisional; Region: PRK05362 441952000488 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 441952000489 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 441952000490 intersubunit interface [polypeptide binding]; other site 441952000491 active site 441952000492 catalytic residue [active] 441952000493 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 441952000494 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 441952000495 Nucleoside recognition; Region: Gate; pfam07670 441952000496 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 441952000497 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 441952000498 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 441952000499 Nucleoside recognition; Region: Gate; pfam07670 441952000500 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 441952000501 thymidylate kinase; Validated; Region: tmk; PRK00698 441952000502 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 441952000503 TMP-binding site; other site 441952000504 ATP-binding site [chemical binding]; other site 441952000505 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 441952000506 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 441952000507 G1 box; other site 441952000508 putative GEF interaction site [polypeptide binding]; other site 441952000509 GTP/Mg2+ binding site [chemical binding]; other site 441952000510 Switch I region; other site 441952000511 G2 box; other site 441952000512 G3 box; other site 441952000513 Switch II region; other site 441952000514 G4 box; other site 441952000515 G5 box; other site 441952000516 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 441952000517 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 441952000518 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 441952000519 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 441952000520 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 441952000521 GTP binding site [chemical binding]; other site 441952000522 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 441952000523 Part of AAA domain; Region: AAA_19; pfam13245 441952000524 Family description; Region: UvrD_C_2; pfam13538 441952000525 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 441952000526 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 441952000527 peptide binding site [polypeptide binding]; other site 441952000528 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 441952000529 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 441952000530 Walker A/P-loop; other site 441952000531 ATP binding site [chemical binding]; other site 441952000532 Q-loop/lid; other site 441952000533 ABC transporter signature motif; other site 441952000534 Walker B; other site 441952000535 D-loop; other site 441952000536 H-loop/switch region; other site 441952000537 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 441952000538 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952000539 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441952000540 putative substrate translocation pore; other site 441952000541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952000542 putative substrate translocation pore; other site 441952000543 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441952000544 glycerol kinase; Provisional; Region: glpK; PRK00047 441952000545 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 441952000546 N- and C-terminal domain interface [polypeptide binding]; other site 441952000547 active site 441952000548 MgATP binding site [chemical binding]; other site 441952000549 catalytic site [active] 441952000550 metal binding site [ion binding]; metal-binding site 441952000551 glycerol binding site [chemical binding]; other site 441952000552 homotetramer interface [polypeptide binding]; other site 441952000553 homodimer interface [polypeptide binding]; other site 441952000554 FBP binding site [chemical binding]; other site 441952000555 protein IIAGlc interface [polypeptide binding]; other site 441952000556 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 441952000557 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 441952000558 amphipathic channel; other site 441952000559 Asn-Pro-Ala signature motifs; other site 441952000560 Mechanosensitive ion channel; Region: MS_channel; pfam00924 441952000561 elongation factor Tu; Reviewed; Region: PRK00049 441952000562 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 441952000563 G1 box; other site 441952000564 GEF interaction site [polypeptide binding]; other site 441952000565 GTP/Mg2+ binding site [chemical binding]; other site 441952000566 Switch I region; other site 441952000567 G2 box; other site 441952000568 G3 box; other site 441952000569 Switch II region; other site 441952000570 G4 box; other site 441952000571 G5 box; other site 441952000572 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 441952000573 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 441952000574 Antibiotic Binding Site [chemical binding]; other site 441952000575 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 441952000576 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 441952000577 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 441952000578 putative homodimer interface [polypeptide binding]; other site 441952000579 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 441952000580 heterodimer interface [polypeptide binding]; other site 441952000581 homodimer interface [polypeptide binding]; other site 441952000582 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 441952000583 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 441952000584 23S rRNA interface [nucleotide binding]; other site 441952000585 L7/L12 interface [polypeptide binding]; other site 441952000586 putative thiostrepton binding site; other site 441952000587 L25 interface [polypeptide binding]; other site 441952000588 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 441952000589 mRNA/rRNA interface [nucleotide binding]; other site 441952000590 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 441952000591 23S rRNA interface [nucleotide binding]; other site 441952000592 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 441952000593 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 441952000594 core dimer interface [polypeptide binding]; other site 441952000595 peripheral dimer interface [polypeptide binding]; other site 441952000596 L10 interface [polypeptide binding]; other site 441952000597 L11 interface [polypeptide binding]; other site 441952000598 putative EF-Tu interaction site [polypeptide binding]; other site 441952000599 putative EF-G interaction site [polypeptide binding]; other site 441952000600 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 441952000601 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 441952000602 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 441952000603 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 441952000604 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 441952000605 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 441952000606 RPB3 interaction site [polypeptide binding]; other site 441952000607 RPB1 interaction site [polypeptide binding]; other site 441952000608 RPB11 interaction site [polypeptide binding]; other site 441952000609 RPB10 interaction site [polypeptide binding]; other site 441952000610 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 441952000611 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 441952000612 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 441952000613 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 441952000614 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 441952000615 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 441952000616 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 441952000617 cleft; other site 441952000618 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 441952000619 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 441952000620 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 441952000621 DNA binding site [nucleotide binding] 441952000622 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 441952000623 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 441952000624 UGMP family protein; Validated; Region: PRK09604 441952000625 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 441952000626 Fatty acid desaturase; Region: FA_desaturase; pfam00487 441952000627 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 441952000628 Di-iron ligands [ion binding]; other site 441952000629 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 441952000630 S-adenosylmethionine synthetase; Validated; Region: PRK05250 441952000631 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 441952000632 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 441952000633 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 441952000634 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 441952000635 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14591 441952000636 RimM N-terminal domain; Region: RimM; pfam01782 441952000637 PRC-barrel domain; Region: PRC; pfam05239 441952000638 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 441952000639 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 441952000640 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 441952000641 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 441952000642 active site 441952000643 DNA binding site [nucleotide binding] 441952000644 Int/Topo IB signature motif; other site 441952000645 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 441952000646 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 441952000647 putative active site [active] 441952000648 Ap4A binding site [chemical binding]; other site 441952000649 nudix motif; other site 441952000650 putative metal binding site [ion binding]; other site 441952000651 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 441952000652 active site 441952000653 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 441952000654 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 441952000655 amidase catalytic site [active] 441952000656 Zn binding residues [ion binding]; other site 441952000657 substrate binding site [chemical binding]; other site 441952000658 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 441952000659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441952000660 Mg2+ binding site [ion binding]; other site 441952000661 G-X-G motif; other site 441952000662 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 441952000663 anchoring element; other site 441952000664 dimer interface [polypeptide binding]; other site 441952000665 ATP binding site [chemical binding]; other site 441952000666 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 441952000667 active site 441952000668 metal binding site [ion binding]; metal-binding site 441952000669 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 441952000670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952000671 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 441952000672 putative substrate translocation pore; other site 441952000673 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 441952000674 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 441952000675 Trp docking motif [polypeptide binding]; other site 441952000676 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441952000677 TPR motif; other site 441952000678 binding surface 441952000679 Tetratricopeptide repeat; Region: TPR_16; pfam13432 441952000680 glutamyl-tRNA reductase; Provisional; Region: PRK13940 441952000681 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 441952000682 tRNA; other site 441952000683 putative tRNA binding site [nucleotide binding]; other site 441952000684 putative NADP binding site [chemical binding]; other site 441952000685 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 441952000686 peptide chain release factor 1; Validated; Region: prfA; PRK00591 441952000687 This domain is found in peptide chain release factors; Region: PCRF; smart00937 441952000688 RF-1 domain; Region: RF-1; pfam00472 441952000689 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 441952000690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441952000691 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 441952000692 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 441952000693 ring oligomerisation interface [polypeptide binding]; other site 441952000694 ATP/Mg binding site [chemical binding]; other site 441952000695 stacking interactions; other site 441952000696 hinge regions; other site 441952000697 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 441952000698 oligomerisation interface [polypeptide binding]; other site 441952000699 mobile loop; other site 441952000700 roof hairpin; other site 441952000701 Predicted membrane protein [Function unknown]; Region: COG4125 441952000702 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 441952000703 hypothetical protein; Validated; Region: PRK02101 441952000704 ProQ/FINO family; Region: ProQ; pfam04352 441952000705 Cation transport protein; Region: TrkH; cl17365 441952000706 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 441952000707 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 441952000708 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 441952000709 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 441952000710 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 441952000711 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 441952000712 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 441952000713 active site 441952000714 lysine transporter; Provisional; Region: PRK10836 441952000715 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 441952000716 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 441952000717 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 441952000718 putative active site [active] 441952000719 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 441952000720 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 441952000721 DXD motif; other site 441952000722 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 441952000723 Domain of unknown function DUF21; Region: DUF21; pfam01595 441952000724 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 441952000725 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 441952000726 Coenzyme A binding pocket [chemical binding]; other site 441952000727 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 441952000728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952000729 putative substrate translocation pore; other site 441952000730 HemK family putative methylases; Region: hemK_fam; TIGR00536 441952000731 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441952000732 S-adenosylmethionine binding site [chemical binding]; other site 441952000733 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 441952000734 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 441952000735 active site 441952000736 HIGH motif; other site 441952000737 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 441952000738 KMSKS motif; other site 441952000739 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 441952000740 tRNA binding surface [nucleotide binding]; other site 441952000741 anticodon binding site; other site 441952000742 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 441952000743 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 441952000744 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 441952000745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441952000746 VacJ like lipoprotein; Region: VacJ; cl01073 441952000747 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 441952000748 short chain dehydrogenase; Provisional; Region: PRK05993 441952000749 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 441952000750 NADP binding site [chemical binding]; other site 441952000751 active site 441952000752 steroid binding site; other site 441952000753 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 441952000754 SnoaL-like domain; Region: SnoaL_2; pfam12680 441952000755 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 441952000756 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 441952000757 ferredoxin-NADP reductase; Provisional; Region: PRK10926 441952000758 FAD binding pocket [chemical binding]; other site 441952000759 FAD binding motif [chemical binding]; other site 441952000760 phosphate binding motif [ion binding]; other site 441952000761 beta-alpha-beta structure motif; other site 441952000762 NAD binding pocket [chemical binding]; other site 441952000763 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 441952000764 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 441952000765 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 441952000766 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 441952000767 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 441952000768 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 441952000769 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 441952000770 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 441952000771 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 441952000772 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 441952000773 active site 441952000774 multimer interface [polypeptide binding]; other site 441952000775 CTP synthetase; Validated; Region: pyrG; PRK05380 441952000776 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 441952000777 Catalytic site [active] 441952000778 active site 441952000779 UTP binding site [chemical binding]; other site 441952000780 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 441952000781 active site 441952000782 putative oxyanion hole; other site 441952000783 catalytic triad [active] 441952000784 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 441952000785 heat shock protein 90; Provisional; Region: PRK05218 441952000786 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441952000787 ATP binding site [chemical binding]; other site 441952000788 Mg2+ binding site [ion binding]; other site 441952000789 G-X-G motif; other site 441952000790 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 441952000791 Fumarase C-terminus; Region: Fumerase_C; pfam05683 441952000792 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 441952000793 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 441952000794 ssDNA binding site; other site 441952000795 generic binding surface II; other site 441952000796 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441952000797 ATP binding site [chemical binding]; other site 441952000798 putative Mg++ binding site [ion binding]; other site 441952000799 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441952000800 nucleotide binding region [chemical binding]; other site 441952000801 ATP-binding site [chemical binding]; other site 441952000802 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627 441952000803 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 441952000804 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 441952000805 septum formation inhibitor; Reviewed; Region: minC; PRK04804 441952000806 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 441952000807 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 441952000808 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 441952000809 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 441952000810 Switch I; other site 441952000811 Switch II; other site 441952000812 cell division topological specificity factor MinE; Provisional; Region: PRK13990 441952000813 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 441952000814 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 441952000815 Walker A/P-loop; other site 441952000816 ATP binding site [chemical binding]; other site 441952000817 Q-loop/lid; other site 441952000818 ABC transporter signature motif; other site 441952000819 Walker B; other site 441952000820 D-loop; other site 441952000821 H-loop/switch region; other site 441952000822 Permease; Region: Permease; pfam02405 441952000823 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 441952000824 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 441952000825 mce related protein; Region: MCE; pfam02470 441952000826 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 441952000827 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 441952000828 anti sigma factor interaction site; other site 441952000829 regulatory phosphorylation site [posttranslational modification]; other site 441952000830 BolA-like protein; Region: BolA; cl00386 441952000831 Restriction endonuclease [Defense mechanisms]; Region: COG3587 441952000832 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441952000833 ATP binding site [chemical binding]; other site 441952000834 putative Mg++ binding site [ion binding]; other site 441952000835 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 441952000836 ligand binding site [chemical binding]; other site 441952000837 active site 441952000838 UGI interface [polypeptide binding]; other site 441952000839 catalytic site [active] 441952000840 DNA gyrase subunit A; Validated; Region: PRK05560 441952000841 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 441952000842 CAP-like domain; other site 441952000843 active site 441952000844 primary dimer interface [polypeptide binding]; other site 441952000845 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 441952000846 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 441952000847 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 441952000848 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 441952000849 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 441952000850 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 441952000851 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 441952000852 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 441952000853 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 441952000854 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 441952000855 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 441952000856 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 441952000857 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 441952000858 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 441952000859 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 441952000860 Surface antigen; Region: Bac_surface_Ag; pfam01103 441952000861 periplasmic chaperone; Provisional; Region: PRK10780 441952000862 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 441952000863 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 441952000864 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 441952000865 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 441952000866 trimer interface [polypeptide binding]; other site 441952000867 active site 441952000868 UDP-GlcNAc binding site [chemical binding]; other site 441952000869 lipid binding site [chemical binding]; lipid-binding site 441952000870 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 441952000871 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 441952000872 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 441952000873 active site 441952000874 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 441952000875 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 441952000876 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 441952000877 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 441952000878 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 441952000879 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 441952000880 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 441952000881 substrate binding pocket [chemical binding]; other site 441952000882 chain length determination region; other site 441952000883 substrate-Mg2+ binding site; other site 441952000884 catalytic residues [active] 441952000885 aspartate-rich region 1; other site 441952000886 active site lid residues [active] 441952000887 aspartate-rich region 2; other site 441952000888 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 441952000889 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 441952000890 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 441952000891 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 441952000892 active site 441952000893 dimerization interface [polypeptide binding]; other site 441952000894 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 441952000895 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 441952000896 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441952000897 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441952000898 active site 441952000899 phosphorylation site [posttranslational modification] 441952000900 intermolecular recognition site; other site 441952000901 dimerization interface [polypeptide binding]; other site 441952000902 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441952000903 DNA binding site [nucleotide binding] 441952000904 signal peptidase I; Provisional; Region: PRK10861 441952000905 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 441952000906 Catalytic site [active] 441952000907 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 441952000908 ribonuclease III; Reviewed; Region: rnc; PRK00102 441952000909 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 441952000910 dimerization interface [polypeptide binding]; other site 441952000911 active site 441952000912 metal binding site [ion binding]; metal-binding site 441952000913 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 441952000914 dsRNA binding site [nucleotide binding]; other site 441952000915 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 441952000916 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 441952000917 RNA binding site [nucleotide binding]; other site 441952000918 active site 441952000919 ribonuclease R; Region: RNase_R; TIGR02063 441952000920 RNB domain; Region: RNB; pfam00773 441952000921 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 441952000922 RNA binding site [nucleotide binding]; other site 441952000923 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 441952000924 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952000925 NAD(P) binding site [chemical binding]; other site 441952000926 active site 441952000927 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441952000928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441952000929 active site 441952000930 phosphorylation site [posttranslational modification] 441952000931 intermolecular recognition site; other site 441952000932 dimerization interface [polypeptide binding]; other site 441952000933 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441952000934 DNA binding site [nucleotide binding] 441952000935 uncharacterized proteobacterial lipoprotein; Region: lp_; TIGR02722 441952000936 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 441952000937 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 441952000938 Amidinotransferase; Region: Amidinotransf; pfam02274 441952000939 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 441952000940 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 441952000941 active site 441952000942 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 441952000943 CoenzymeA binding site [chemical binding]; other site 441952000944 subunit interaction site [polypeptide binding]; other site 441952000945 PHB binding site; other site 441952000946 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 441952000947 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 441952000948 dimer interface [polypeptide binding]; other site 441952000949 active site 441952000950 Acyl CoA binding protein; Region: ACBP; pfam00887 441952000951 acyl-CoA binding pocket [chemical binding]; other site 441952000952 CoA binding site [chemical binding]; other site 441952000953 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 441952000954 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 441952000955 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 441952000956 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 441952000957 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 441952000958 substrate binding site [chemical binding]; other site 441952000959 oxyanion hole (OAH) forming residues; other site 441952000960 trimer interface [polypeptide binding]; other site 441952000961 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 441952000962 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 441952000963 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 441952000964 active site 441952000965 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 441952000966 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 441952000967 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 441952000968 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 441952000969 acyl-activating enzyme (AAE) consensus motif; other site 441952000970 putative AMP binding site [chemical binding]; other site 441952000971 putative active site [active] 441952000972 putative CoA binding site [chemical binding]; other site 441952000973 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 441952000974 ArsC family; Region: ArsC; pfam03960 441952000975 catalytic residues [active] 441952000976 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 441952000977 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 441952000978 DEAD-like helicases superfamily; Region: DEXDc; smart00487 441952000979 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441952000980 ATP binding site [chemical binding]; other site 441952000981 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 441952000982 putative Mg++ binding site [ion binding]; other site 441952000983 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441952000984 nucleotide binding region [chemical binding]; other site 441952000985 ATP-binding site [chemical binding]; other site 441952000986 Helicase associated domain (HA2); Region: HA2; pfam04408 441952000987 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 441952000988 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 441952000989 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 441952000990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 441952000991 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 441952000992 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 441952000993 DNA binding site [nucleotide binding] 441952000994 active site 441952000995 Uncharacterized conserved protein [Function unknown]; Region: COG0398 441952000996 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 441952000997 mercuric reductase; Validated; Region: PRK06370 441952000998 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441952000999 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 441952001000 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 441952001001 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 441952001002 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 441952001003 HSP70 interaction site [polypeptide binding]; other site 441952001004 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 441952001005 substrate binding site [polypeptide binding]; other site 441952001006 dimer interface [polypeptide binding]; other site 441952001007 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 441952001008 EamA-like transporter family; Region: EamA; pfam00892 441952001009 Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in...; Region: PI3Ka; cl00271 441952001010 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 441952001011 HD domain; Region: HD_4; pfam13328 441952001012 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 441952001013 synthetase active site [active] 441952001014 NTP binding site [chemical binding]; other site 441952001015 metal binding site [ion binding]; metal-binding site 441952001016 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 441952001017 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 441952001018 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441952001019 S-adenosylmethionine binding site [chemical binding]; other site 441952001020 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 441952001021 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 441952001022 active site 441952001023 DNA binding site [nucleotide binding] 441952001024 Int/Topo IB signature motif; other site 441952001025 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 441952001026 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 441952001027 preprotein translocase subunit SecB; Validated; Region: PRK05751 441952001028 SecA binding site; other site 441952001029 Preprotein binding site; other site 441952001030 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 441952001031 MutS domain I; Region: MutS_I; pfam01624 441952001032 MutS domain III; Region: MutS_III; pfam05192 441952001033 MutS domain V; Region: MutS_V; pfam00488 441952001034 Walker A/P-loop; other site 441952001035 ATP binding site [chemical binding]; other site 441952001036 Q-loop/lid; other site 441952001037 ABC transporter signature motif; other site 441952001038 Walker B; other site 441952001039 D-loop; other site 441952001040 H-loop/switch region; other site 441952001041 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 441952001042 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 441952001043 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 441952001044 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 441952001045 putative active site [active] 441952001046 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 441952001047 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 441952001048 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 441952001049 active site 441952001050 HIGH motif; other site 441952001051 dimer interface [polypeptide binding]; other site 441952001052 KMSKS motif; other site 441952001053 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 441952001054 dephospho-CoA kinase; Region: TIGR00152 441952001055 CoA-binding site [chemical binding]; other site 441952001056 ATP-binding [chemical binding]; other site 441952001057 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 441952001058 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 441952001059 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 441952001060 dimer interface [polypeptide binding]; other site 441952001061 TPP-binding site [chemical binding]; other site 441952001062 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 441952001063 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 441952001064 E3 interaction surface; other site 441952001065 lipoyl attachment site [posttranslational modification]; other site 441952001066 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 441952001067 E3 interaction surface; other site 441952001068 lipoyl attachment site [posttranslational modification]; other site 441952001069 e3 binding domain; Region: E3_binding; pfam02817 441952001070 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 441952001071 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 441952001072 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 441952001073 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 441952001074 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441952001075 NAD binding site [chemical binding]; other site 441952001076 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 441952001077 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 441952001078 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 441952001079 nudix motif; other site 441952001080 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 441952001081 ArsC family; Region: ArsC; pfam03960 441952001082 catalytic residue [active] 441952001083 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 441952001084 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 441952001085 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441952001086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441952001087 homodimer interface [polypeptide binding]; other site 441952001088 catalytic residue [active] 441952001089 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 441952001090 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 441952001091 ligand binding site [chemical binding]; other site 441952001092 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 441952001093 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 441952001094 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 441952001095 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 441952001096 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 441952001097 homotrimer interaction site [polypeptide binding]; other site 441952001098 active site 441952001099 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 441952001100 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 441952001101 TolQ protein; Region: tolQ; TIGR02796 441952001102 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 441952001103 TolR protein; Region: tolR; TIGR02801 441952001104 TolA protein; Region: tolA_full; TIGR02794 441952001105 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 441952001106 TolB amino-terminal domain; Region: TolB_N; pfam04052 441952001107 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 441952001108 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 441952001109 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 441952001110 ligand binding site [chemical binding]; other site 441952001111 C factor cell-cell signaling protein; Provisional; Region: PRK09009 441952001112 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 441952001113 NADP binding site [chemical binding]; other site 441952001114 homodimer interface [polypeptide binding]; other site 441952001115 active site 441952001116 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 441952001117 DNA photolyase; Region: DNA_photolyase; pfam00875 441952001118 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 441952001119 bile acid transporter; Region: bass; TIGR00841 441952001120 Sodium Bile acid symporter family; Region: SBF; cl17470 441952001121 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 441952001122 hypothetical protein; Provisional; Region: PRK10621 441952001123 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 441952001124 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 441952001125 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 441952001126 transmembrane helices; other site 441952001127 Protein of unknown function (DUF423); Region: DUF423; pfam04241 441952001128 Protein of unknown function, DUF393; Region: DUF393; pfam04134 441952001129 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12847 441952001130 UbiA prenyltransferase family; Region: UbiA; pfam01040 441952001131 Chorismate lyase; Region: Chor_lyase; cl01230 441952001132 ribonuclease PH; Reviewed; Region: rph; PRK00173 441952001133 Ribonuclease PH; Region: RNase_PH_bact; cd11362 441952001134 hexamer interface [polypeptide binding]; other site 441952001135 active site 441952001136 heat shock protein HtpX; Provisional; Region: PRK02870 441952001137 LemA family; Region: LemA; cl00742 441952001138 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 441952001139 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 441952001140 dimerization interface [polypeptide binding]; other site 441952001141 putative DNA binding site [nucleotide binding]; other site 441952001142 putative Zn2+ binding site [ion binding]; other site 441952001143 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 441952001144 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 441952001145 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 441952001146 Colicin V production protein; Region: Colicin_V; pfam02674 441952001147 DNA repair protein RadA; Provisional; Region: PRK11823 441952001148 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 441952001149 Walker A motif/ATP binding site; other site 441952001150 ATP binding site [chemical binding]; other site 441952001151 Walker B motif; other site 441952001152 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 441952001153 PilZ domain; Region: PilZ; pfam07238 441952001154 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 441952001155 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 441952001156 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 441952001157 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 441952001158 Tetramer interface [polypeptide binding]; other site 441952001159 active site 441952001160 FMN-binding site [chemical binding]; other site 441952001161 PQ loop repeat; Region: PQ-loop; cl17546 441952001162 PQ loop repeat; Region: PQ-loop; pfam04193 441952001163 methionine sulfoxide reductase B; Provisional; Region: PRK00222 441952001164 SelR domain; Region: SelR; pfam01641 441952001165 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 441952001166 E-class dimer interface [polypeptide binding]; other site 441952001167 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 441952001168 P-class dimer interface [polypeptide binding]; other site 441952001169 active site 441952001170 Cu2+ binding site [ion binding]; other site 441952001171 Zn2+ binding site [ion binding]; other site 441952001172 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 441952001173 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 441952001174 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 441952001175 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 441952001176 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 441952001177 NAD(P) binding site [chemical binding]; other site 441952001178 aspartate aminotransferase; Provisional; Region: PRK07568 441952001179 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441952001180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441952001181 homodimer interface [polypeptide binding]; other site 441952001182 catalytic residue [active] 441952001183 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 441952001184 Cation efflux family; Region: Cation_efflux; pfam01545 441952001185 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 441952001186 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 441952001187 Walker A/P-loop; other site 441952001188 ATP binding site [chemical binding]; other site 441952001189 Q-loop/lid; other site 441952001190 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 441952001191 ABC transporter signature motif; other site 441952001192 Walker B; other site 441952001193 D-loop; other site 441952001194 H-loop/switch region; other site 441952001195 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 441952001196 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 441952001197 Pilin (bacterial filament); Region: Pilin; pfam00114 441952001198 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 441952001199 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 441952001200 active site 441952001201 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14180 441952001202 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 441952001203 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 441952001204 homodimer interface [polypeptide binding]; other site 441952001205 NADP binding site [chemical binding]; other site 441952001206 substrate binding site [chemical binding]; other site 441952001207 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 441952001208 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 441952001209 dimerization interface [polypeptide binding]; other site 441952001210 putative ATP binding site [chemical binding]; other site 441952001211 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 441952001212 active site 441952001213 ATP binding site [chemical binding]; other site 441952001214 substrate binding site [chemical binding]; other site 441952001215 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 441952001216 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 441952001217 ATP-grasp domain; Region: ATP-grasp_4; cl17255 441952001218 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 441952001219 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 441952001220 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 441952001221 active site 441952001222 substrate binding site [chemical binding]; other site 441952001223 cosubstrate binding site; other site 441952001224 catalytic site [active] 441952001225 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 441952001226 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 441952001227 ATP-grasp domain; Region: ATP-grasp; pfam02222 441952001228 hypothetical protein; Provisional; Region: PRK14682 441952001229 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 441952001230 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 441952001231 active site 441952001232 Zn binding site [ion binding]; other site 441952001233 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 441952001234 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 441952001235 DNA topoisomerase I; Validated; Region: PRK06599 441952001236 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 441952001237 active site 441952001238 interdomain interaction site; other site 441952001239 putative metal-binding site [ion binding]; other site 441952001240 nucleotide binding site [chemical binding]; other site 441952001241 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 441952001242 domain I; other site 441952001243 DNA binding groove [nucleotide binding] 441952001244 phosphate binding site [ion binding]; other site 441952001245 domain II; other site 441952001246 domain III; other site 441952001247 nucleotide binding site [chemical binding]; other site 441952001248 catalytic site [active] 441952001249 domain IV; other site 441952001250 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 441952001251 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 441952001252 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 441952001253 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 441952001254 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 441952001255 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 441952001256 P-loop; other site 441952001257 Magnesium ion binding site [ion binding]; other site 441952001258 ParB-like nuclease domain; Region: ParB; smart00470 441952001259 KorB domain; Region: KorB; pfam08535 441952001260 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 441952001261 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 441952001262 catalytic triad [active] 441952001263 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 441952001264 active site 441952001265 catalytic triad [active] 441952001266 oxyanion hole [active] 441952001267 FtsJ-like methyltransferase; Region: FtsJ; cl17430 441952001268 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 441952001269 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 441952001270 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 441952001271 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 441952001272 active site 441952001273 HIGH motif; other site 441952001274 nucleotide binding site [chemical binding]; other site 441952001275 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 441952001276 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 441952001277 active site 441952001278 KMSKS motif; other site 441952001279 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 441952001280 tRNA binding surface [nucleotide binding]; other site 441952001281 anticodon binding site; other site 441952001282 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 441952001283 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 441952001284 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 441952001285 active site 441952001286 Riboflavin kinase; Region: Flavokinase; pfam01687 441952001287 malate dehydrogenase; Provisional; Region: PRK13529 441952001288 Malic enzyme, N-terminal domain; Region: malic; pfam00390 441952001289 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 441952001290 NAD(P) binding pocket [chemical binding]; other site 441952001291 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 441952001292 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 441952001293 GTP-binding protein Der; Reviewed; Region: PRK00093 441952001294 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 441952001295 G1 box; other site 441952001296 GTP/Mg2+ binding site [chemical binding]; other site 441952001297 Switch I region; other site 441952001298 G2 box; other site 441952001299 Switch II region; other site 441952001300 G3 box; other site 441952001301 G4 box; other site 441952001302 G5 box; other site 441952001303 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 441952001304 G1 box; other site 441952001305 GTP/Mg2+ binding site [chemical binding]; other site 441952001306 Switch I region; other site 441952001307 G2 box; other site 441952001308 G3 box; other site 441952001309 Switch II region; other site 441952001310 G4 box; other site 441952001311 G5 box; other site 441952001312 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 441952001313 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 441952001314 putative active site [active] 441952001315 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 441952001316 FAD binding domain; Region: FAD_binding_4; pfam01565 441952001317 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 441952001318 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 441952001319 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 441952001320 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 441952001321 nucleotide binding site/active site [active] 441952001322 HIT family signature motif; other site 441952001323 catalytic residue [active] 441952001324 ABC1 family; Region: ABC1; cl17513 441952001325 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 441952001326 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 441952001327 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 441952001328 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441952001329 S-adenosylmethionine binding site [chemical binding]; other site 441952001330 Glucokinase; Region: Glucokinase; pfam02685 441952001331 glucokinase, proteobacterial type; Region: glk; TIGR00749 441952001332 Intracellular septation protein A; Region: IspA; pfam04279 441952001333 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 441952001334 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 441952001335 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 441952001336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952001337 D-galactonate transporter; Region: 2A0114; TIGR00893 441952001338 putative substrate translocation pore; other site 441952001339 Neurotransmitter-gated ion-channel ligand binding domain; Region: Neur_chan_LBD; pfam02931 441952001340 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 441952001341 Peptidase family M50; Region: Peptidase_M50; pfam02163 441952001342 active site 441952001343 putative substrate binding region [chemical binding]; other site 441952001344 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 441952001345 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 441952001346 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional proteins, also containing a Nudix hydrolase domain; Region: NMNAT_Nudix; cd02168 441952001347 active site 441952001348 (T/H)XGH motif; other site 441952001349 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 441952001350 nudix motif; other site 441952001351 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 441952001352 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 441952001353 Substrate binding site; other site 441952001354 Mg++ binding site; other site 441952001355 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 441952001356 active site 441952001357 substrate binding site [chemical binding]; other site 441952001358 CoA binding site [chemical binding]; other site 441952001359 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 441952001360 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 441952001361 glutaminase active site [active] 441952001362 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 441952001363 dimer interface [polypeptide binding]; other site 441952001364 active site 441952001365 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 441952001366 dimer interface [polypeptide binding]; other site 441952001367 active site 441952001368 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 441952001369 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 441952001370 DNA-binding site [nucleotide binding]; DNA binding site 441952001371 RNA-binding motif; other site 441952001372 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 441952001373 metal binding site [ion binding]; metal-binding site 441952001374 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 441952001375 active site 441952001376 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 441952001377 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 441952001378 CAP-like domain; other site 441952001379 active site 441952001380 primary dimer interface [polypeptide binding]; other site 441952001381 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 441952001382 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 441952001383 BNR repeat-like domain; Region: BNR_2; pfam13088 441952001384 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 441952001385 Asp-box motif; other site 441952001386 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 441952001387 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 441952001388 N-acetyl-D-glucosamine binding site [chemical binding]; other site 441952001389 catalytic residue [active] 441952001390 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 441952001391 Predicted membrane protein [Function unknown]; Region: COG4325 441952001392 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 441952001393 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 441952001394 putative active site [active] 441952001395 putative PHP Thumb interface [polypeptide binding]; other site 441952001396 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 441952001397 generic binding surface II; other site 441952001398 generic binding surface I; other site 441952001399 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 441952001400 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 441952001401 FtsX-like permease family; Region: FtsX; pfam02687 441952001402 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 441952001403 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 441952001404 Walker A/P-loop; other site 441952001405 ATP binding site [chemical binding]; other site 441952001406 Q-loop/lid; other site 441952001407 ABC transporter signature motif; other site 441952001408 Walker B; other site 441952001409 D-loop; other site 441952001410 H-loop/switch region; other site 441952001411 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 441952001412 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 441952001413 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 441952001414 lipoyl attachment site [posttranslational modification]; other site 441952001415 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 441952001416 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 441952001417 tetramer interface [polypeptide binding]; other site 441952001418 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441952001419 catalytic residue [active] 441952001420 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 441952001421 tetramer interface [polypeptide binding]; other site 441952001422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441952001423 catalytic residue [active] 441952001424 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 441952001425 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 441952001426 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 441952001427 shikimate binding site; other site 441952001428 NAD(P) binding site [chemical binding]; other site 441952001429 pullulanase, type I; Region: pulA_typeI; TIGR02104 441952001430 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 441952001431 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 441952001432 Ca binding site [ion binding]; other site 441952001433 active site 441952001434 catalytic site [active] 441952001435 glycogen branching enzyme; Provisional; Region: PRK12313 441952001436 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 441952001437 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 441952001438 active site 441952001439 catalytic site [active] 441952001440 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 441952001441 phosphoglucomutase; Region: PLN02307 441952001442 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 441952001443 substrate binding site [chemical binding]; other site 441952001444 dimer interface [polypeptide binding]; other site 441952001445 active site 441952001446 metal binding site [ion binding]; metal-binding site 441952001447 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 441952001448 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 441952001449 ligand binding site; other site 441952001450 oligomer interface; other site 441952001451 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 441952001452 dimer interface [polypeptide binding]; other site 441952001453 N-terminal domain interface [polypeptide binding]; other site 441952001454 sulfate 1 binding site; other site 441952001455 glycogen synthase; Provisional; Region: glgA; PRK00654 441952001456 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 441952001457 ADP-binding pocket [chemical binding]; other site 441952001458 homodimer interface [polypeptide binding]; other site 441952001459 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 441952001460 homodimer interface [polypeptide binding]; other site 441952001461 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 441952001462 active site pocket [active] 441952001463 4-alpha-glucanotransferase; Provisional; Region: PRK14508 441952001464 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 441952001465 dimer interface [polypeptide binding]; other site 441952001466 motif 1; other site 441952001467 active site 441952001468 motif 2; other site 441952001469 motif 3; other site 441952001470 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 441952001471 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 441952001472 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 441952001473 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 441952001474 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 441952001475 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 441952001476 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 441952001477 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 441952001478 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 441952001479 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 441952001480 nucleotide binding site [chemical binding]; other site 441952001481 substrate binding site [chemical binding]; other site 441952001482 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 441952001483 dimer interface [polypeptide binding]; other site 441952001484 putative threonine allosteric regulatory site; other site 441952001485 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 441952001486 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 441952001487 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 441952001488 homoserine kinase; Provisional; Region: PRK01212 441952001489 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 441952001490 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 441952001491 spermidine synthase; Provisional; Region: PRK00811 441952001492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441952001493 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 441952001494 dimer interface [polypeptide binding]; other site 441952001495 active site 441952001496 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 441952001497 catalytic residues [active] 441952001498 substrate binding site [chemical binding]; other site 441952001499 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 441952001500 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 441952001501 putative active site; other site 441952001502 catalytic triad [active] 441952001503 putative dimer interface [polypeptide binding]; other site 441952001504 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 441952001505 putative active site [active] 441952001506 putative metal binding site [ion binding]; other site 441952001507 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441952001508 active site 441952001509 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 441952001510 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 441952001511 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 441952001512 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 441952001513 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 441952001514 dimerization interface [polypeptide binding]; other site 441952001515 putative DNA binding site [nucleotide binding]; other site 441952001516 putative Zn2+ binding site [ion binding]; other site 441952001517 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 441952001518 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 441952001519 hypothetical protein; Provisional; Region: PRK05170 441952001520 transcription antitermination factor NusB; Region: nusB; TIGR01951 441952001521 putative RNA binding site [nucleotide binding]; other site 441952001522 C-N hydrolase family amidase; Provisional; Region: PRK10438 441952001523 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 441952001524 putative active site [active] 441952001525 catalytic triad [active] 441952001526 dimer interface [polypeptide binding]; other site 441952001527 multimer interface [polypeptide binding]; other site 441952001528 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 441952001529 methionine aminotransferase; Validated; Region: PRK09082 441952001530 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441952001531 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441952001532 homodimer interface [polypeptide binding]; other site 441952001533 catalytic residue [active] 441952001534 prolyl-tRNA synthetase; Provisional; Region: PRK09194 441952001535 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 441952001536 dimer interface [polypeptide binding]; other site 441952001537 motif 1; other site 441952001538 active site 441952001539 motif 2; other site 441952001540 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 441952001541 putative deacylase active site [active] 441952001542 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 441952001543 active site 441952001544 motif 3; other site 441952001545 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 441952001546 anticodon binding site; other site 441952001547 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 441952001548 Fe-S metabolism associated domain; Region: SufE; cl00951 441952001549 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 441952001550 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 441952001551 active site 441952001552 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 441952001553 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 441952001554 Sporulation related domain; Region: SPOR; pfam05036 441952001555 FeoA domain; Region: FeoA; cl00838 441952001556 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 441952001557 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441952001558 non-specific DNA binding site [nucleotide binding]; other site 441952001559 salt bridge; other site 441952001560 sequence-specific DNA binding site [nucleotide binding]; other site 441952001561 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 441952001562 Catalytic site [active] 441952001563 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 441952001564 EamA-like transporter family; Region: EamA; pfam00892 441952001565 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 441952001566 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 441952001567 active site 441952001568 FMN binding site [chemical binding]; other site 441952001569 substrate binding site [chemical binding]; other site 441952001570 3Fe-4S cluster binding site [ion binding]; other site 441952001571 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 441952001572 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 441952001573 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 441952001574 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 441952001575 Divergent AAA domain; Region: AAA_4; pfam04326 441952001576 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 441952001577 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 441952001578 putative DNA binding site [nucleotide binding]; other site 441952001579 putative Zn2+ binding site [ion binding]; other site 441952001580 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 441952001581 Family description; Region: UvrD_C_2; pfam13538 441952001582 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 441952001583 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 441952001584 AAA domain; Region: AAA_30; pfam13604 441952001585 Family description; Region: UvrD_C_2; pfam13538 441952001586 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 441952001587 nucleotide binding site [chemical binding]; other site 441952001588 Type III pantothenate kinase; Region: Pan_kinase; cl17198 441952001589 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 441952001590 tetramerization interface [polypeptide binding]; other site 441952001591 active site 441952001592 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 441952001593 pantoate--beta-alanine ligase; Region: panC; TIGR00018 441952001594 active site 441952001595 nucleotide binding site [chemical binding]; other site 441952001596 HIGH motif; other site 441952001597 KMSKS motif; other site 441952001598 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 441952001599 active site 441952001600 oligomerization interface [polypeptide binding]; other site 441952001601 metal binding site [ion binding]; metal-binding site 441952001602 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 441952001603 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 441952001604 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 441952001605 nucleotide binding pocket [chemical binding]; other site 441952001606 K-X-D-G motif; other site 441952001607 catalytic site [active] 441952001608 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 441952001609 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 441952001610 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 441952001611 Dimer interface [polypeptide binding]; other site 441952001612 BRCT sequence motif; other site 441952001613 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 441952001614 16S rRNA methyltransferase B; Provisional; Region: PRK10901 441952001615 NusB family; Region: NusB; pfam01029 441952001616 putative RNA binding site [nucleotide binding]; other site 441952001617 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441952001618 S-adenosylmethionine binding site [chemical binding]; other site 441952001619 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 441952001620 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 441952001621 active site 441952001622 dimerization interface [polypeptide binding]; other site 441952001623 putative transporter; Provisional; Region: PRK03699 441952001624 Uncharacterized conserved protein [Function unknown]; Region: COG4121 441952001625 YCII-related domain; Region: YCII; cl00999 441952001626 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 441952001627 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 441952001628 dimer interface [polypeptide binding]; other site 441952001629 active site 441952001630 acyl carrier protein; Provisional; Region: acpP; PRK00982 441952001631 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 441952001632 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 441952001633 NAD(P) binding site [chemical binding]; other site 441952001634 homotetramer interface [polypeptide binding]; other site 441952001635 homodimer interface [polypeptide binding]; other site 441952001636 active site 441952001637 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 441952001638 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 441952001639 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 441952001640 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 441952001641 dimer interface [polypeptide binding]; other site 441952001642 active site 441952001643 CoA binding pocket [chemical binding]; other site 441952001644 putative phosphate acyltransferase; Provisional; Region: PRK05331 441952001645 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 441952001646 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 441952001647 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 441952001648 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 441952001649 TPP-binding site [chemical binding]; other site 441952001650 dimer interface [polypeptide binding]; other site 441952001651 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 441952001652 PYR/PP interface [polypeptide binding]; other site 441952001653 dimer interface [polypeptide binding]; other site 441952001654 TPP binding site [chemical binding]; other site 441952001655 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 441952001656 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 441952001657 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 441952001658 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 441952001659 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 441952001660 Phosphoglycerate kinase; Region: PGK; pfam00162 441952001661 substrate binding site [chemical binding]; other site 441952001662 hinge regions; other site 441952001663 ADP binding site [chemical binding]; other site 441952001664 catalytic site [active] 441952001665 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 441952001666 pyruvate kinase; Provisional; Region: PRK05826 441952001667 domain interfaces; other site 441952001668 active site 441952001669 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 441952001670 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 441952001671 intersubunit interface [polypeptide binding]; other site 441952001672 active site 441952001673 zinc binding site [ion binding]; other site 441952001674 Na+ binding site [ion binding]; other site 441952001675 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 441952001676 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441952001677 Walker A/P-loop; other site 441952001678 ATP binding site [chemical binding]; other site 441952001679 Q-loop/lid; other site 441952001680 ABC transporter signature motif; other site 441952001681 Walker B; other site 441952001682 D-loop; other site 441952001683 H-loop/switch region; other site 441952001684 TOBE domain; Region: TOBE_2; pfam08402 441952001685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441952001686 dimer interface [polypeptide binding]; other site 441952001687 conserved gate region; other site 441952001688 putative PBP binding loops; other site 441952001689 ABC-ATPase subunit interface; other site 441952001690 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 441952001691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441952001692 dimer interface [polypeptide binding]; other site 441952001693 conserved gate region; other site 441952001694 putative PBP binding loops; other site 441952001695 ABC-ATPase subunit interface; other site 441952001696 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 441952001697 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 441952001698 hinge; other site 441952001699 active site 441952001700 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 441952001701 RNA/DNA hybrid binding site [nucleotide binding]; other site 441952001702 active site 441952001703 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 441952001704 active site 441952001705 homodimer interface [polypeptide binding]; other site 441952001706 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 441952001707 active site clefts [active] 441952001708 zinc binding site [ion binding]; other site 441952001709 dimer interface [polypeptide binding]; other site 441952001710 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 441952001711 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 441952001712 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441952001713 catalytic residue [active] 441952001714 Rubredoxin [Energy production and conversion]; Region: COG1773 441952001715 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 441952001716 iron binding site [ion binding]; other site 441952001717 Uncharacterized conserved protein [Function unknown]; Region: COG0397 441952001718 hypothetical protein; Validated; Region: PRK00029 441952001719 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 441952001720 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 441952001721 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 441952001722 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 441952001723 dimer interface [polypeptide binding]; other site 441952001724 active site 441952001725 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 441952001726 dimer interface [polypeptide binding]; other site 441952001727 active site 441952001728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952001729 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 441952001730 putative substrate translocation pore; other site 441952001731 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952001732 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 441952001733 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 441952001734 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 441952001735 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 441952001736 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 441952001737 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 441952001738 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 441952001739 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 441952001740 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 441952001741 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 441952001742 active site 441952001743 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 441952001744 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 441952001745 active site 441952001746 substrate binding site [chemical binding]; other site 441952001747 Mg2+ binding site [ion binding]; other site 441952001748 beta-lactamase TEM; Provisional; Region: PRK15442 441952001749 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 441952001750 VirK protein; Region: VirK; pfam06903 441952001751 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 441952001752 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 441952001753 putative active site [active] 441952001754 catalytic triad [active] 441952001755 putative dimer interface [polypeptide binding]; other site 441952001756 FOG: CBS domain [General function prediction only]; Region: COG0517 441952001757 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 441952001758 Transporter associated domain; Region: CorC_HlyC; smart01091 441952001759 metal-binding heat shock protein; Provisional; Region: PRK00016 441952001760 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 441952001761 PhoH-like protein; Region: PhoH; pfam02562 441952001762 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 441952001763 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 441952001764 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441952001765 FeS/SAM binding site; other site 441952001766 TRAM domain; Region: TRAM; pfam01938 441952001767 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 441952001768 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 441952001769 thymidine kinase; Provisional; Region: PRK04296 441952001770 trigger factor; Provisional; Region: tig; PRK01490 441952001771 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 441952001772 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 441952001773 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 441952001774 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 441952001775 oligomer interface [polypeptide binding]; other site 441952001776 active site residues [active] 441952001777 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 441952001778 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 441952001779 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441952001780 Walker A motif; other site 441952001781 ATP binding site [chemical binding]; other site 441952001782 Walker B motif; other site 441952001783 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 441952001784 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 441952001785 Found in ATP-dependent protease La (LON); Region: LON; smart00464 441952001786 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441952001787 Walker A motif; other site 441952001788 ATP binding site [chemical binding]; other site 441952001789 Walker B motif; other site 441952001790 arginine finger; other site 441952001791 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 441952001792 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 441952001793 IHF dimer interface [polypeptide binding]; other site 441952001794 IHF - DNA interface [nucleotide binding]; other site 441952001795 SurA N-terminal domain; Region: SurA_N_3; cl07813 441952001796 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 441952001797 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 441952001798 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 441952001799 bacterial Hfq-like; Region: Hfq; cd01716 441952001800 hexamer interface [polypeptide binding]; other site 441952001801 Sm1 motif; other site 441952001802 RNA binding site [nucleotide binding]; other site 441952001803 Sm2 motif; other site 441952001804 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 441952001805 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 441952001806 HflX GTPase family; Region: HflX; cd01878 441952001807 G1 box; other site 441952001808 GTP/Mg2+ binding site [chemical binding]; other site 441952001809 Switch I region; other site 441952001810 G2 box; other site 441952001811 G3 box; other site 441952001812 Switch II region; other site 441952001813 G4 box; other site 441952001814 G5 box; other site 441952001815 hypothetical protein; Provisional; Region: PRK07588 441952001816 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 441952001817 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 441952001818 HflK protein; Region: hflK; TIGR01933 441952001819 FtsH protease regulator HflC; Provisional; Region: PRK11029 441952001820 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 441952001821 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 441952001822 Low molecular weight phosphatase family; Region: LMWPc; cd00115 441952001823 active site 441952001824 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 441952001825 G1 box; other site 441952001826 GTP/Mg2+ binding site [chemical binding]; other site 441952001827 Switch I region; other site 441952001828 G2 box; other site 441952001829 G3 box; other site 441952001830 Switch II region; other site 441952001831 G4 box; other site 441952001832 G5 box; other site 441952001833 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 441952001834 Ligand Binding Site [chemical binding]; other site 441952001835 TilS substrate C-terminal domain; Region: TilS_C; smart00977 441952001836 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 441952001837 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 441952001838 ligand binding site [chemical binding]; other site 441952001839 NAD binding site [chemical binding]; other site 441952001840 tetramer interface [polypeptide binding]; other site 441952001841 catalytic site [active] 441952001842 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 441952001843 L-serine binding site [chemical binding]; other site 441952001844 ACT domain interface; other site 441952001845 thymidylate synthase; Reviewed; Region: thyA; PRK01827 441952001846 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 441952001847 dimerization interface [polypeptide binding]; other site 441952001848 active site 441952001849 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 441952001850 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 441952001851 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 441952001852 homodimer interface [polypeptide binding]; other site 441952001853 oligonucleotide binding site [chemical binding]; other site 441952001854 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 441952001855 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 441952001856 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441952001857 catalytic residue [active] 441952001858 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 441952001859 Recombination protein O N terminal; Region: RecO_N; pfam11967 441952001860 Recombination protein O C terminal; Region: RecO_C; pfam02565 441952001861 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 441952001862 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 441952001863 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 441952001864 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 441952001865 BolA-like protein; Region: BolA; cl00386 441952001866 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 441952001867 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 441952001868 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 441952001869 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 441952001870 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 441952001871 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 441952001872 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 441952001873 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 441952001874 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 441952001875 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441952001876 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 441952001877 active site 441952001878 motif I; other site 441952001879 motif II; other site 441952001880 Soluble P-type ATPase [General function prediction only]; Region: COG4087 441952001881 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 441952001882 Uncharacterized conserved protein [Function unknown]; Region: COG2835 441952001883 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 441952001884 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 441952001885 Ligand binding site; other site 441952001886 oligomer interface; other site 441952001887 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 441952001888 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 441952001889 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 441952001890 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 441952001891 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 441952001892 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 441952001893 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 441952001894 dimer interface [polypeptide binding]; other site 441952001895 active site 441952001896 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952001897 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 441952001898 putative substrate translocation pore; other site 441952001899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952001900 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 441952001901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952001902 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 441952001903 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 441952001904 helicase 45; Provisional; Region: PTZ00424 441952001905 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 441952001906 ATP binding site [chemical binding]; other site 441952001907 Mg++ binding site [ion binding]; other site 441952001908 motif III; other site 441952001909 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441952001910 nucleotide binding region [chemical binding]; other site 441952001911 ATP-binding site [chemical binding]; other site 441952001912 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 441952001913 putative RNA binding site [nucleotide binding]; other site 441952001914 Guanylate kinase; Region: Guanylate_kin; pfam00625 441952001915 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 441952001916 catalytic site [active] 441952001917 G-X2-G-X-G-K; other site 441952001918 quinolinate synthetase; Provisional; Region: PRK09375 441952001919 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 441952001920 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 441952001921 dimerization interface [polypeptide binding]; other site 441952001922 active site 441952001923 L-aspartate oxidase; Provisional; Region: PRK09077 441952001924 L-aspartate oxidase; Provisional; Region: PRK06175 441952001925 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 441952001926 Chorismate mutase type II; Region: CM_2; smart00830 441952001927 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 441952001928 catalytic residues [active] 441952001929 dimer interface [polypeptide binding]; other site 441952001930 Putative serine esterase (DUF676); Region: DUF676; pfam05057 441952001931 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 441952001932 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 441952001933 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 441952001934 putative substrate binding site [chemical binding]; other site 441952001935 putative ATP binding site [chemical binding]; other site 441952001936 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441952001937 RNA binding surface [nucleotide binding]; other site 441952001938 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 441952001939 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 441952001940 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 441952001941 HlyD family secretion protein; Region: HlyD_3; pfam13437 441952001942 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 441952001943 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 441952001944 non-specific DNA interactions [nucleotide binding]; other site 441952001945 DNA binding site [nucleotide binding] 441952001946 sequence specific DNA binding site [nucleotide binding]; other site 441952001947 putative cAMP binding site [chemical binding]; other site 441952001948 Bacterial transcriptional regulator; Region: IclR; pfam01614 441952001949 Radical SAM superfamily; Region: Radical_SAM; pfam04055 441952001950 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441952001951 FeS/SAM binding site; other site 441952001952 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 441952001953 DNA-binding site [nucleotide binding]; DNA binding site 441952001954 RNA-binding motif; other site 441952001955 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 441952001956 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 441952001957 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 441952001958 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 441952001959 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 441952001960 active site 441952001961 tetramer interface; other site 441952001962 EamA-like transporter family; Region: EamA; pfam00892 441952001963 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 441952001964 EamA-like transporter family; Region: EamA; pfam00892 441952001965 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 441952001966 recombination protein F; Reviewed; Region: recF; PRK00064 441952001967 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441952001968 Walker A/P-loop; other site 441952001969 ATP binding site [chemical binding]; other site 441952001970 Q-loop/lid; other site 441952001971 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441952001972 ABC transporter signature motif; other site 441952001973 Walker B; other site 441952001974 D-loop; other site 441952001975 H-loop/switch region; other site 441952001976 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 441952001977 active site 441952001978 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 441952001979 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 441952001980 tetramer (dimer of dimers) interface [polypeptide binding]; other site 441952001981 active site 441952001982 dimer interface [polypeptide binding]; other site 441952001983 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 441952001984 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 441952001985 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 441952001986 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 441952001987 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441952001988 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441952001989 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 441952001990 putative effector binding pocket; other site 441952001991 dimerization interface [polypeptide binding]; other site 441952001992 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 441952001993 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952001994 NAD(P) binding site [chemical binding]; other site 441952001995 active site 441952001996 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 441952001997 active site 441952001998 catalytic site [active] 441952001999 substrate binding site [chemical binding]; other site 441952002000 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 441952002001 excinuclease ABC subunit B; Provisional; Region: PRK05298 441952002002 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441952002003 ATP binding site [chemical binding]; other site 441952002004 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441952002005 nucleotide binding region [chemical binding]; other site 441952002006 ATP-binding site [chemical binding]; other site 441952002007 Ultra-violet resistance protein B; Region: UvrB; pfam12344 441952002008 UvrB/uvrC motif; Region: UVR; pfam02151 441952002009 Nuclease-related domain; Region: NERD; pfam08378 441952002010 glutamate racemase; Provisional; Region: PRK00865 441952002011 metabolite-proton symporter; Region: 2A0106; TIGR00883 441952002012 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 441952002013 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 441952002014 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 441952002015 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 441952002016 generic binding surface II; other site 441952002017 generic binding surface I; other site 441952002018 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 441952002019 SmpB-tmRNA interface; other site 441952002020 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 441952002021 putative coenzyme Q binding site [chemical binding]; other site 441952002022 hypothetical protein; Validated; Region: PRK01777 441952002023 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 441952002024 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 441952002025 VacJ like lipoprotein; Region: VacJ; cl01073 441952002026 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 441952002027 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 441952002028 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441952002029 S-adenosylmethionine binding site [chemical binding]; other site 441952002030 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 441952002031 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 441952002032 G1 box; other site 441952002033 putative GEF interaction site [polypeptide binding]; other site 441952002034 GTP/Mg2+ binding site [chemical binding]; other site 441952002035 Switch I region; other site 441952002036 G2 box; other site 441952002037 G3 box; other site 441952002038 Switch II region; other site 441952002039 G4 box; other site 441952002040 G5 box; other site 441952002041 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 441952002042 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 441952002043 HsdM N-terminal domain; Region: HsdM_N; pfam12161 441952002044 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 441952002045 Methyltransferase domain; Region: Methyltransf_26; pfam13659 441952002046 Sel1-like repeats; Region: SEL1; smart00671 441952002047 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 441952002048 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 441952002049 GTP/Mg2+ binding site [chemical binding]; other site 441952002050 G4 box; other site 441952002051 G5 box; other site 441952002052 G1 box; other site 441952002053 Switch I region; other site 441952002054 G2 box; other site 441952002055 G3 box; other site 441952002056 Switch II region; other site 441952002057 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 441952002058 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 441952002059 active site 441952002060 dimer interface [polypeptide binding]; other site 441952002061 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 441952002062 Glycoprotease family; Region: Peptidase_M22; pfam00814 441952002063 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 441952002064 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 441952002065 putative active site [active] 441952002066 putative dimer interface [polypeptide binding]; other site 441952002067 aspartate aminotransferase; Provisional; Region: PRK05764 441952002068 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441952002069 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441952002070 homodimer interface [polypeptide binding]; other site 441952002071 catalytic residue [active] 441952002072 GTPase Era; Reviewed; Region: era; PRK00089 441952002073 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 441952002074 G1 box; other site 441952002075 GTP/Mg2+ binding site [chemical binding]; other site 441952002076 Switch I region; other site 441952002077 G2 box; other site 441952002078 Switch II region; other site 441952002079 G3 box; other site 441952002080 G4 box; other site 441952002081 G5 box; other site 441952002082 adenylate kinase; Reviewed; Region: adk; PRK00279 441952002083 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 441952002084 AMP-binding site [chemical binding]; other site 441952002085 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 441952002086 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 441952002087 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 441952002088 Pilus assembly protein, PilP; Region: PilP; pfam04351 441952002089 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 441952002090 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 441952002091 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 441952002092 shikimate kinase; Reviewed; Region: aroK; PRK00131 441952002093 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 441952002094 ADP binding site [chemical binding]; other site 441952002095 magnesium binding site [ion binding]; other site 441952002096 putative shikimate binding site; other site 441952002097 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 441952002098 active site 441952002099 dimer interface [polypeptide binding]; other site 441952002100 metal binding site [ion binding]; metal-binding site 441952002101 Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937 441952002102 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 441952002103 Proline dehydrogenase; Region: Pro_dh; pfam01619 441952002104 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 441952002105 Glutamate binding site [chemical binding]; other site 441952002106 NAD binding site [chemical binding]; other site 441952002107 catalytic residues [active] 441952002108 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 441952002109 NAD(P) binding site [chemical binding]; other site 441952002110 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 441952002111 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 441952002112 benzoate transport; Region: 2A0115; TIGR00895 441952002113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952002114 putative substrate translocation pore; other site 441952002115 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 441952002116 Flavoprotein; Region: Flavoprotein; pfam02441 441952002117 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 441952002118 cation transport regulator; Reviewed; Region: chaB; PRK09582 441952002119 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 441952002120 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 441952002121 nucleotide binding site [chemical binding]; other site 441952002122 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 441952002123 AAA domain; Region: AAA_26; pfam13500 441952002124 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 441952002125 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 441952002126 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 441952002127 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441952002128 catalytic residue [active] 441952002129 biotin synthase; Region: bioB; TIGR00433 441952002130 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441952002131 FeS/SAM binding site; other site 441952002132 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 441952002133 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 441952002134 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 441952002135 inhibitor-cofactor binding pocket; inhibition site 441952002136 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441952002137 catalytic residue [active] 441952002138 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 441952002139 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 441952002140 dimer interface [polypeptide binding]; other site 441952002141 active site 441952002142 glycine-pyridoxal phosphate binding site [chemical binding]; other site 441952002143 folate binding site [chemical binding]; other site 441952002144 hypothetical protein; Provisional; Region: PRK05255 441952002145 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 441952002146 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 441952002147 Ligand binding site; other site 441952002148 metal-binding site 441952002149 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 441952002150 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441952002151 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 441952002152 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 441952002153 active site 441952002154 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 441952002155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952002156 putative substrate translocation pore; other site 441952002157 POT family; Region: PTR2; cl17359 441952002158 Antirestriction protein (ArdA); Region: ArdA; pfam07275 441952002159 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 441952002160 Restriction endonuclease [Defense mechanisms]; Region: COG3587 441952002161 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441952002162 ATP binding site [chemical binding]; other site 441952002163 putative Mg++ binding site [ion binding]; other site 441952002164 Restriction endonuclease [Defense mechanisms]; Region: COG3587 441952002165 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 441952002166 putative active site [active] 441952002167 putative NTP binding site [chemical binding]; other site 441952002168 putative nucleic acid binding site [nucleotide binding]; other site 441952002169 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 441952002170 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 441952002171 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 441952002172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 441952002173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441952002174 S-adenosylmethionine binding site [chemical binding]; other site 441952002175 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 441952002176 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 441952002177 putative active site [active] 441952002178 substrate binding site [chemical binding]; other site 441952002179 putative cosubstrate binding site; other site 441952002180 catalytic site [active] 441952002181 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 441952002182 substrate binding site [chemical binding]; other site 441952002183 glutathione synthetase; Provisional; Region: PRK05246 441952002184 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 441952002185 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 441952002186 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 441952002187 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 441952002188 inhibitor-cofactor binding pocket; inhibition site 441952002189 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441952002190 catalytic residue [active] 441952002191 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 441952002192 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 441952002193 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 441952002194 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 441952002195 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 441952002196 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 441952002197 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 441952002198 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 441952002199 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 441952002200 replicative DNA helicase; Region: DnaB; TIGR00665 441952002201 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 441952002202 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 441952002203 Walker A motif; other site 441952002204 ATP binding site [chemical binding]; other site 441952002205 Walker B motif; other site 441952002206 DNA binding loops [nucleotide binding] 441952002207 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 441952002208 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441952002209 FeS/SAM binding site; other site 441952002210 Tetratricopeptide repeat; Region: TPR_12; pfam13424 441952002211 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 441952002212 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441952002213 RNA binding surface [nucleotide binding]; other site 441952002214 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 441952002215 probable active site [active] 441952002216 preprotein translocase subunit SecA; Validated; Region: secA; CHL00122 441952002217 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 441952002218 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 441952002219 Coenzyme A binding pocket [chemical binding]; other site 441952002220 PQ loop repeat; Region: PQ-loop; pfam04193 441952002221 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 441952002222 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 441952002223 substrate binding pocket [chemical binding]; other site 441952002224 chain length determination region; other site 441952002225 substrate-Mg2+ binding site; other site 441952002226 catalytic residues [active] 441952002227 aspartate-rich region 1; other site 441952002228 active site lid residues [active] 441952002229 aspartate-rich region 2; other site 441952002230 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 441952002231 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 441952002232 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 441952002233 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 441952002234 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 441952002235 Ligand Binding Site [chemical binding]; other site 441952002236 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 441952002237 active site 441952002238 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 441952002239 N-acetyl-D-glucosamine binding site [chemical binding]; other site 441952002240 catalytic residue [active] 441952002241 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 441952002242 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 441952002243 Yqey-like protein; Region: YqeY; pfam09424 441952002244 CHC2 zinc finger; Region: zf-CHC2; pfam01807 441952002245 DNA primase; Validated; Region: dnaG; PRK05667 441952002246 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 441952002247 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 441952002248 active site 441952002249 metal binding site [ion binding]; metal-binding site 441952002250 interdomain interaction site; other site 441952002251 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 441952002252 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 441952002253 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 441952002254 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 441952002255 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 441952002256 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441952002257 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 441952002258 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 441952002259 DNA binding residues [nucleotide binding] 441952002260 lipoate-protein ligase B; Provisional; Region: PRK14342 441952002261 Protein of unknown function (DUF493); Region: DUF493; pfam04359 441952002262 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 441952002263 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 441952002264 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 441952002265 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 441952002266 dimer interface [polypeptide binding]; other site 441952002267 substrate binding site [chemical binding]; other site 441952002268 metal binding sites [ion binding]; metal-binding site 441952002269 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 441952002270 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441952002271 active site 441952002272 motif I; other site 441952002273 motif II; other site 441952002274 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 441952002275 OstA-like protein; Region: OstA; cl00844 441952002276 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 441952002277 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 441952002278 Walker A/P-loop; other site 441952002279 ATP binding site [chemical binding]; other site 441952002280 Q-loop/lid; other site 441952002281 ABC transporter signature motif; other site 441952002282 Walker B; other site 441952002283 D-loop; other site 441952002284 H-loop/switch region; other site 441952002285 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 441952002286 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 441952002287 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 441952002288 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 441952002289 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 441952002290 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 441952002291 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 441952002292 dimerization interface 3.5A [polypeptide binding]; other site 441952002293 active site 441952002294 amino acid transporter; Region: 2A0306; TIGR00909 441952002295 GMP synthase; Reviewed; Region: guaA; PRK00074 441952002296 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 441952002297 AMP/PPi binding site [chemical binding]; other site 441952002298 candidate oxyanion hole; other site 441952002299 catalytic triad [active] 441952002300 potential glutamine specificity residues [chemical binding]; other site 441952002301 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 441952002302 ATP Binding subdomain [chemical binding]; other site 441952002303 Ligand Binding sites [chemical binding]; other site 441952002304 Dimerization subdomain; other site 441952002305 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 441952002306 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 441952002307 TPP-binding site; other site 441952002308 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 441952002309 PYR/PP interface [polypeptide binding]; other site 441952002310 dimer interface [polypeptide binding]; other site 441952002311 TPP binding site [chemical binding]; other site 441952002312 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 441952002313 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 441952002314 putative active site pocket [active] 441952002315 dimerization interface [polypeptide binding]; other site 441952002316 putative catalytic residue [active] 441952002317 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 441952002318 active site 441952002319 oxyanion hole [active] 441952002320 catalytic triad [active] 441952002321 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 441952002322 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 441952002323 classical (c) SDRs; Region: SDR_c; cd05233 441952002324 NAD(P) binding site [chemical binding]; other site 441952002325 active site 441952002326 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 441952002327 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441952002328 Walker A motif; other site 441952002329 ATP binding site [chemical binding]; other site 441952002330 Walker B motif; other site 441952002331 arginine finger; other site 441952002332 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 441952002333 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 441952002334 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 441952002335 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441952002336 non-specific DNA binding site [nucleotide binding]; other site 441952002337 salt bridge; other site 441952002338 sequence-specific DNA binding site [nucleotide binding]; other site 441952002339 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 441952002340 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 441952002341 catalytic motif [active] 441952002342 Catalytic residue [active] 441952002343 Aspartyl protease; Region: Asp_protease_2; pfam13650 441952002344 inhibitor binding site; inhibition site 441952002345 catalytic motif [active] 441952002346 Catalytic residue [active] 441952002347 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 441952002348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952002349 EamA-like transporter family; Region: EamA; pfam00892 441952002350 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 441952002351 EamA-like transporter family; Region: EamA; pfam00892 441952002352 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 441952002353 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 441952002354 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 441952002355 dimer interface [polypeptide binding]; other site 441952002356 motif 1; other site 441952002357 active site 441952002358 motif 2; other site 441952002359 motif 3; other site 441952002360 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 441952002361 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 441952002362 putative tRNA-binding site [nucleotide binding]; other site 441952002363 B3/4 domain; Region: B3_4; pfam03483 441952002364 tRNA synthetase B5 domain; Region: B5; smart00874 441952002365 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 441952002366 dimer interface [polypeptide binding]; other site 441952002367 motif 1; other site 441952002368 motif 3; other site 441952002369 motif 2; other site 441952002370 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 441952002371 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 441952002372 metal binding site 2 [ion binding]; metal-binding site 441952002373 putative DNA binding helix; other site 441952002374 metal binding site 1 [ion binding]; metal-binding site 441952002375 dimer interface [polypeptide binding]; other site 441952002376 structural Zn2+ binding site [ion binding]; other site 441952002377 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 441952002378 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 441952002379 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 441952002380 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 441952002381 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 441952002382 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 441952002383 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156 441952002384 putative active site [active] 441952002385 catalytic site [active] 441952002386 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162 441952002387 putative active site [active] 441952002388 catalytic site [active] 441952002389 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 441952002390 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 441952002391 Walker A motif; other site 441952002392 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 441952002393 trimer interface [polypeptide binding]; other site 441952002394 active site 441952002395 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 441952002396 Mechanosensitive ion channel; Region: MS_channel; pfam00924 441952002397 Lipopolysaccharide-assembly; Region: LptE; cl01125 441952002398 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 441952002399 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 441952002400 HIGH motif; other site 441952002401 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 441952002402 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 441952002403 active site 441952002404 KMSKS motif; other site 441952002405 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 441952002406 tRNA binding surface [nucleotide binding]; other site 441952002407 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 441952002408 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 441952002409 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 441952002410 Transglutaminase/protease-like homologues; Region: TGc; smart00460 441952002411 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 441952002412 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 441952002413 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 441952002414 PAS fold; Region: PAS_4; pfam08448 441952002415 hypothetical protein; Provisional; Region: PRK07505 441952002416 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 441952002417 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441952002418 catalytic residue [active] 441952002419 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 441952002420 Transcriptional regulators [Transcription]; Region: MarR; COG1846 441952002421 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 441952002422 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 441952002423 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 441952002424 catalytic residues [active] 441952002425 FeS assembly protein SufD; Region: sufD; TIGR01981 441952002426 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 441952002427 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 441952002428 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 441952002429 Walker A/P-loop; other site 441952002430 ATP binding site [chemical binding]; other site 441952002431 Q-loop/lid; other site 441952002432 ABC transporter signature motif; other site 441952002433 Walker B; other site 441952002434 D-loop; other site 441952002435 H-loop/switch region; other site 441952002436 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 441952002437 putative ABC transporter; Region: ycf24; CHL00085 441952002438 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 441952002439 Transcriptional regulator; Region: Rrf2; pfam02082 441952002440 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 441952002441 TrkA-N domain; Region: TrkA_N; pfam02254 441952002442 TrkA-N domain; Region: TrkA_N; pfam02254 441952002443 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 441952002444 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 441952002445 rRNA binding site [nucleotide binding]; other site 441952002446 predicted 30S ribosome binding site; other site 441952002447 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 441952002448 signal recognition particle protein; Provisional; Region: PRK10867 441952002449 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 441952002450 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 441952002451 P loop; other site 441952002452 GTP binding site [chemical binding]; other site 441952002453 Signal peptide binding domain; Region: SRP_SPB; pfam02978 441952002454 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 441952002455 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 441952002456 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 441952002457 putative active site [active] 441952002458 putative catalytic site [active] 441952002459 putative DNA binding site [nucleotide binding]; other site 441952002460 putative phosphate binding site [ion binding]; other site 441952002461 metal binding site A [ion binding]; metal-binding site 441952002462 putative AP binding site [nucleotide binding]; other site 441952002463 putative metal binding site B [ion binding]; other site 441952002464 short chain dehydrogenase; Provisional; Region: PRK07577 441952002465 classical (c) SDRs; Region: SDR_c; cd05233 441952002466 NAD(P) binding site [chemical binding]; other site 441952002467 active site 441952002468 AAA domain; Region: AAA_17; pfam13207 441952002469 AAA domain; Region: AAA_18; pfam13238 441952002470 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 441952002471 glutathione reductase; Validated; Region: PRK06116 441952002472 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441952002473 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 441952002474 Uncharacterized conserved protein [Function unknown]; Region: COG0393 441952002475 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 441952002476 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952002477 putative substrate translocation pore; other site 441952002478 POT family; Region: PTR2; cl17359 441952002479 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 441952002480 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 441952002481 ATP binding site [chemical binding]; other site 441952002482 Mg++ binding site [ion binding]; other site 441952002483 motif III; other site 441952002484 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441952002485 nucleotide binding region [chemical binding]; other site 441952002486 ATP-binding site [chemical binding]; other site 441952002487 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 441952002488 GTP cyclohydrolase I; Provisional; Region: PLN03044 441952002489 active site 441952002490 Predicted amidohydrolase [General function prediction only]; Region: COG0388 441952002491 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 441952002492 active site 441952002493 catalytic triad [active] 441952002494 dimer interface [polypeptide binding]; other site 441952002495 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 441952002496 Glutamine amidotransferase class-I; Region: GATase; pfam00117 441952002497 glutamine binding [chemical binding]; other site 441952002498 catalytic triad [active] 441952002499 aminodeoxychorismate synthase; Provisional; Region: PRK07508 441952002500 chorismate binding enzyme; Region: Chorismate_bind; cl10555 441952002501 Aminotransferase class IV; Region: Aminotran_4; pfam01063 441952002502 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 441952002503 substrate-cofactor binding pocket; other site 441952002504 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441952002505 catalytic residue [active] 441952002506 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 441952002507 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 441952002508 acyl-activating enzyme (AAE) consensus motif; other site 441952002509 AMP binding site [chemical binding]; other site 441952002510 active site 441952002511 CoA binding site [chemical binding]; other site 441952002512 Dihydroneopterin aldolase; Region: FolB; smart00905 441952002513 active site 441952002514 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 441952002515 catalytic center binding site [active] 441952002516 ATP binding site [chemical binding]; other site 441952002517 dihydropteroate synthase; Region: DHPS; TIGR01496 441952002518 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 441952002519 substrate binding pocket [chemical binding]; other site 441952002520 dimer interface [polypeptide binding]; other site 441952002521 inhibitor binding site; inhibition site 441952002522 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 441952002523 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 441952002524 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 441952002525 active site 2 [active] 441952002526 active site 1 [active] 441952002527 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 441952002528 Uncharacterized conserved protein [Function unknown]; Region: COG0398 441952002529 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 441952002530 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 441952002531 23S rRNA binding site [nucleotide binding]; other site 441952002532 L21 binding site [polypeptide binding]; other site 441952002533 L13 binding site [polypeptide binding]; other site 441952002534 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 441952002535 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 441952002536 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 441952002537 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 441952002538 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 441952002539 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 441952002540 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 441952002541 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 441952002542 active site 441952002543 dimer interface [polypeptide binding]; other site 441952002544 motif 1; other site 441952002545 motif 2; other site 441952002546 motif 3; other site 441952002547 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 441952002548 anticodon binding site; other site 441952002549 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 441952002550 lipoyl attachment site [posttranslational modification]; other site 441952002551 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 441952002552 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 441952002553 homodimer interface [polypeptide binding]; other site 441952002554 active site 441952002555 hypothetical protein; Validated; Region: PRK00153 441952002556 recombination protein RecR; Provisional; Region: PRK13844 441952002557 RecR protein; Region: RecR; pfam02132 441952002558 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 441952002559 putative active site [active] 441952002560 putative metal-binding site [ion binding]; other site 441952002561 tetramer interface [polypeptide binding]; other site 441952002562 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 441952002563 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441952002564 Zn2+ binding site [ion binding]; other site 441952002565 Mg2+ binding site [ion binding]; other site 441952002566 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 441952002567 synthetase active site [active] 441952002568 NTP binding site [chemical binding]; other site 441952002569 metal binding site [ion binding]; metal-binding site 441952002570 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 441952002571 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 441952002572 poly-gamma-glutamate system protein; Region: gamma_Glu_sys; TIGR04332 441952002573 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 441952002574 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 441952002575 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 441952002576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952002577 metabolite-proton symporter; Region: 2A0106; TIGR00883 441952002578 putative substrate translocation pore; other site 441952002579 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 441952002580 catalytic nucleophile [active] 441952002581 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 441952002582 proposed catalytic triad [active] 441952002583 active site nucleophile [active] 441952002584 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 441952002585 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 441952002586 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 441952002587 substrate binding site [chemical binding]; other site 441952002588 ATP binding site [chemical binding]; other site 441952002589 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 441952002590 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441952002591 motif II; other site 441952002592 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 441952002593 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441952002594 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 441952002595 active site 441952002596 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 441952002597 active site 441952002598 LicD family; Region: LicD; pfam04991 441952002599 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441952002600 S-adenosylmethionine binding site [chemical binding]; other site 441952002601 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 441952002602 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 441952002603 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 441952002604 active site 441952002605 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441952002606 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441952002607 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441952002608 Walker A/P-loop; other site 441952002609 ATP binding site [chemical binding]; other site 441952002610 Q-loop/lid; other site 441952002611 ABC transporter signature motif; other site 441952002612 Walker B; other site 441952002613 D-loop; other site 441952002614 H-loop/switch region; other site 441952002615 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441952002616 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 441952002617 putative ADP-binding pocket [chemical binding]; other site 441952002618 UDP-glucose 4-epimerase; Region: PLN02240 441952002619 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 441952002620 NAD binding site [chemical binding]; other site 441952002621 homodimer interface [polypeptide binding]; other site 441952002622 active site 441952002623 substrate binding site [chemical binding]; other site 441952002624 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 441952002625 Bacterial sugar transferase; Region: Bac_transf; pfam02397 441952002626 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 441952002627 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 441952002628 substrate binding site [chemical binding]; other site 441952002629 hexamer interface [polypeptide binding]; other site 441952002630 metal binding site [ion binding]; metal-binding site 441952002631 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 441952002632 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 441952002633 putative active site [active] 441952002634 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 441952002635 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 441952002636 hypothetical protein; Provisional; Region: PRK05409 441952002637 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 441952002638 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 441952002639 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 441952002640 NAD binding site [chemical binding]; other site 441952002641 homotetramer interface [polypeptide binding]; other site 441952002642 homodimer interface [polypeptide binding]; other site 441952002643 substrate binding site [chemical binding]; other site 441952002644 active site 441952002645 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 441952002646 chaperone protein DnaJ; Provisional; Region: PRK10767 441952002647 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 441952002648 HSP70 interaction site [polypeptide binding]; other site 441952002649 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 441952002650 substrate binding site [polypeptide binding]; other site 441952002651 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 441952002652 Zn binding sites [ion binding]; other site 441952002653 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 441952002654 dimer interface [polypeptide binding]; other site 441952002655 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 441952002656 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 441952002657 nucleotide binding site [chemical binding]; other site 441952002658 GrpE; Region: GrpE; pfam01025 441952002659 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 441952002660 dimer interface [polypeptide binding]; other site 441952002661 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 441952002662 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 441952002663 MltA specific insert domain; Region: MltA; smart00925 441952002664 3D domain; Region: 3D; pfam06725 441952002665 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 441952002666 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 441952002667 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 441952002668 23S rRNA interface [nucleotide binding]; other site 441952002669 L3 interface [polypeptide binding]; other site 441952002670 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 441952002671 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 441952002672 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 441952002673 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 441952002674 Na binding site [ion binding]; other site 441952002675 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 441952002676 RNA/DNA hybrid binding site [nucleotide binding]; other site 441952002677 active site 441952002678 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 441952002679 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 441952002680 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 441952002681 active site 441952002682 phosphorylation site [posttranslational modification] 441952002683 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 441952002684 30S subunit binding site; other site 441952002685 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 441952002686 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 441952002687 trmE is a tRNA modification GTPase; Region: trmE; cd04164 441952002688 G1 box; other site 441952002689 GTP/Mg2+ binding site [chemical binding]; other site 441952002690 Switch I region; other site 441952002691 G2 box; other site 441952002692 Switch II region; other site 441952002693 G3 box; other site 441952002694 G4 box; other site 441952002695 G5 box; other site 441952002696 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 441952002697 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 441952002698 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 441952002699 dimer interface [polypeptide binding]; other site 441952002700 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441952002701 catalytic residue [active] 441952002702 RNA polymerase beta'' subunit; Reviewed; Region: rpoC2; CHL00117 441952002703 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 441952002704 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 441952002705 Intracellular growth locus C protein; Region: IglC; pfam11550 441952002706 Protein of unknown function (DUF877); Region: DUF877; pfam05943 441952002707 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 441952002708 type VI secretion protein, VC_A0107 family; Region: VI_chp_5; TIGR03358 441952002709 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 441952002710 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 441952002711 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 441952002712 homodimer interface [polypeptide binding]; other site 441952002713 NAD binding pocket [chemical binding]; other site 441952002714 ATP binding pocket [chemical binding]; other site 441952002715 Mg binding site [ion binding]; other site 441952002716 active-site loop [active] 441952002717 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 441952002718 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 441952002719 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 441952002720 HlyD family secretion protein; Region: HlyD_3; pfam13437 441952002721 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 441952002722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952002723 putative substrate translocation pore; other site 441952002724 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441952002725 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441952002726 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 441952002727 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 441952002728 acyl-activating enzyme (AAE) consensus motif; other site 441952002729 putative AMP binding site [chemical binding]; other site 441952002730 putative active site [active] 441952002731 putative CoA binding site [chemical binding]; other site 441952002732 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 441952002733 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952002734 putative substrate translocation pore; other site 441952002735 POT family; Region: PTR2; cl17359 441952002736 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 441952002737 RNA methyltransferase, RsmE family; Region: TIGR00046 441952002738 Protein of unknown function (DUF445); Region: DUF445; pfam04286 441952002739 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 441952002740 mce related protein; Region: MCE; pfam02470 441952002741 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 441952002742 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441952002743 Walker A/P-loop; other site 441952002744 ATP binding site [chemical binding]; other site 441952002745 Q-loop/lid; other site 441952002746 ABC transporter signature motif; other site 441952002747 Walker B; other site 441952002748 D-loop; other site 441952002749 H-loop/switch region; other site 441952002750 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 441952002751 Permease; Region: Permease; pfam02405 441952002752 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 441952002753 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441952002754 RNA binding surface [nucleotide binding]; other site 441952002755 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 441952002756 active site 441952002757 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 441952002758 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 441952002759 TPR motif; other site 441952002760 binding surface 441952002761 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 441952002762 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441952002763 catalytic residue [active] 441952002764 cytidylate kinase; Provisional; Region: cmk; PRK00023 441952002765 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 441952002766 CMP-binding site; other site 441952002767 The sites determining sugar specificity; other site 441952002768 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 441952002769 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 441952002770 putative NAD(P) binding site [chemical binding]; other site 441952002771 homodimer interface [polypeptide binding]; other site 441952002772 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 441952002773 catalytic triad [active] 441952002774 dimer interface [polypeptide binding]; other site 441952002775 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 441952002776 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441952002777 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 441952002778 dimerization interface [polypeptide binding]; other site 441952002779 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 441952002780 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 441952002781 putative homodimer interface [polypeptide binding]; other site 441952002782 putative homotetramer interface [polypeptide binding]; other site 441952002783 putative allosteric switch controlling residues; other site 441952002784 putative metal binding site [ion binding]; other site 441952002785 putative homodimer-homodimer interface [polypeptide binding]; other site 441952002786 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 441952002787 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 441952002788 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 441952002789 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 441952002790 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 441952002791 active site 441952002792 catalytic site [active] 441952002793 substrate binding site [chemical binding]; other site 441952002794 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 441952002795 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 441952002796 PhnA protein; Region: PhnA; pfam03831 441952002797 peroxidase; Provisional; Region: PRK15000 441952002798 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 441952002799 dimer interface [polypeptide binding]; other site 441952002800 decamer (pentamer of dimers) interface [polypeptide binding]; other site 441952002801 catalytic triad [active] 441952002802 peroxidatic and resolving cysteines [active] 441952002803 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 441952002804 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441952002805 motif II; other site 441952002806 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 441952002807 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 441952002808 N-acetyl-D-glucosamine binding site [chemical binding]; other site 441952002809 catalytic residue [active] 441952002810 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 441952002811 diiron binding motif [ion binding]; other site 441952002812 malate dehydrogenase; Reviewed; Region: PRK06223 441952002813 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 441952002814 NAD(P) binding site [chemical binding]; other site 441952002815 dimer interface [polypeptide binding]; other site 441952002816 tetramer (dimer of dimers) interface [polypeptide binding]; other site 441952002817 substrate binding site [chemical binding]; other site 441952002818 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 441952002819 Class I ribonucleotide reductase; Region: RNR_I; cd01679 441952002820 active site 441952002821 dimer interface [polypeptide binding]; other site 441952002822 catalytic residues [active] 441952002823 effector binding site; other site 441952002824 R2 peptide binding site; other site 441952002825 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 441952002826 GSH binding site [chemical binding]; other site 441952002827 catalytic residues [active] 441952002828 bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta; Provisional; Region: PRK12759 441952002829 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 441952002830 GSH binding site [chemical binding]; other site 441952002831 catalytic residues [active] 441952002832 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 441952002833 dimer interface [polypeptide binding]; other site 441952002834 putative radical transfer pathway; other site 441952002835 diiron center [ion binding]; other site 441952002836 tyrosyl radical; other site 441952002837 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 441952002838 DJ-1 family protein; Region: not_thiJ; TIGR01383 441952002839 conserved cys residue [active] 441952002840 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 441952002841 active site 441952002842 DNA polymerase IV; Validated; Region: PRK02406 441952002843 DNA binding site [nucleotide binding] 441952002844 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441952002845 AAA domain; Region: AAA_21; pfam13304 441952002846 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441952002847 Walker A/P-loop; other site 441952002848 Walker A/P-loop; other site 441952002849 ATP binding site [chemical binding]; other site 441952002850 ATP binding site [chemical binding]; other site 441952002851 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 441952002852 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 441952002853 Methyltransferase domain; Region: Methyltransf_26; pfam13659 441952002854 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 441952002855 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 441952002856 FMN binding site [chemical binding]; other site 441952002857 active site 441952002858 catalytic residues [active] 441952002859 substrate binding site [chemical binding]; other site 441952002860 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 441952002861 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441952002862 S-adenosylmethionine binding site [chemical binding]; other site 441952002863 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 441952002864 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 441952002865 dimer interface [polypeptide binding]; other site 441952002866 active site 441952002867 metal binding site [ion binding]; metal-binding site 441952002868 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 441952002869 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 441952002870 phosphate binding site [ion binding]; other site 441952002871 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 441952002872 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 441952002873 active site 441952002874 HIGH motif; other site 441952002875 dimer interface [polypeptide binding]; other site 441952002876 KMSKS motif; other site 441952002877 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441952002878 RNA binding surface [nucleotide binding]; other site 441952002879 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 441952002880 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 441952002881 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 441952002882 active site 441952002883 HslU subunit interaction site [polypeptide binding]; other site 441952002884 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 441952002885 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441952002886 Walker A motif; other site 441952002887 ATP binding site [chemical binding]; other site 441952002888 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 441952002889 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 441952002890 Ion channel; Region: Ion_trans_2; pfam07885 441952002891 TrkA-N domain; Region: TrkA_N; pfam02254 441952002892 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 441952002893 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441952002894 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 441952002895 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 441952002896 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 441952002897 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 441952002898 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 441952002899 dimerization domain [polypeptide binding]; other site 441952002900 dimer interface [polypeptide binding]; other site 441952002901 catalytic residues [active] 441952002902 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 441952002903 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 441952002904 putative active site [active] 441952002905 catalytic residue [active] 441952002906 GTP-binding protein YchF; Reviewed; Region: PRK09601 441952002907 YchF GTPase; Region: YchF; cd01900 441952002908 G1 box; other site 441952002909 GTP/Mg2+ binding site [chemical binding]; other site 441952002910 Switch I region; other site 441952002911 G2 box; other site 441952002912 Switch II region; other site 441952002913 G3 box; other site 441952002914 G4 box; other site 441952002915 G5 box; other site 441952002916 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 441952002917 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 441952002918 Domain of unknown function DUF21; Region: DUF21; pfam01595 441952002919 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 441952002920 Transporter associated domain; Region: CorC_HlyC; pfam03471 441952002921 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 441952002922 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 441952002923 5S rRNA interface [nucleotide binding]; other site 441952002924 CTC domain interface [polypeptide binding]; other site 441952002925 L16 interface [polypeptide binding]; other site 441952002926 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 441952002927 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 441952002928 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441952002929 active site 441952002930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952002931 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441952002932 putative substrate translocation pore; other site 441952002933 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 441952002934 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 441952002935 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 441952002936 Isochorismatase family; Region: Isochorismatase; pfam00857 441952002937 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 441952002938 catalytic triad [active] 441952002939 conserved cis-peptide bond; other site 441952002940 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 441952002941 intersubunit interface [polypeptide binding]; other site 441952002942 active site 441952002943 Zn2+ binding site [ion binding]; other site 441952002944 histidine decarboxylase; Provisional; Region: PRK02769 441952002945 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441952002946 catalytic residue [active] 441952002947 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 441952002948 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 441952002949 RmuC family; Region: RmuC; pfam02646 441952002950 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 441952002951 RuvA N terminal domain; Region: RuvA_N; pfam01330 441952002952 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 441952002953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952002954 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441952002955 putative substrate translocation pore; other site 441952002956 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 441952002957 active site 441952002958 putative DNA-binding cleft [nucleotide binding]; other site 441952002959 dimer interface [polypeptide binding]; other site 441952002960 hypothetical protein; Validated; Region: PRK00110 441952002961 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 441952002962 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 441952002963 conserved cys residue [active] 441952002964 lipoyl synthase; Provisional; Region: PRK05481 441952002965 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441952002966 FeS/SAM binding site; other site 441952002967 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 441952002968 Ferritin-like domain; Region: Ferritin; pfam00210 441952002969 ferroxidase diiron center [ion binding]; other site 441952002970 POT family; Region: PTR2; cl17359 441952002971 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 441952002972 glutaredoxin 2; Provisional; Region: PRK10387 441952002973 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 441952002974 C-terminal domain interface [polypeptide binding]; other site 441952002975 GSH binding site (G-site) [chemical binding]; other site 441952002976 catalytic residues [active] 441952002977 putative dimer interface [polypeptide binding]; other site 441952002978 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 441952002979 N-terminal domain interface [polypeptide binding]; other site 441952002980 ferredoxin; Provisional; Region: PRK08764 441952002981 Putative Fe-S cluster; Region: FeS; cl17515 441952002982 4Fe-4S binding domain; Region: Fer4; pfam00037 441952002983 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 441952002984 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 441952002985 minor groove reading motif; other site 441952002986 helix-hairpin-helix signature motif; other site 441952002987 substrate binding pocket [chemical binding]; other site 441952002988 active site 441952002989 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 441952002990 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 441952002991 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 441952002992 YccA-like proteins; Region: YccA_like; cd10433 441952002993 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 441952002994 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 441952002995 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441952002996 ATP binding site [chemical binding]; other site 441952002997 putative Mg++ binding site [ion binding]; other site 441952002998 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441952002999 nucleotide binding region [chemical binding]; other site 441952003000 ATP-binding site [chemical binding]; other site 441952003001 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 441952003002 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 441952003003 putative valine binding site [chemical binding]; other site 441952003004 dimer interface [polypeptide binding]; other site 441952003005 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 441952003006 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441952003007 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441952003008 non-specific DNA binding site [nucleotide binding]; other site 441952003009 salt bridge; other site 441952003010 sequence-specific DNA binding site [nucleotide binding]; other site 441952003011 HipA N-terminal domain; Region: couple_hipA; TIGR03071 441952003012 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 441952003013 HipA-like N-terminal domain; Region: HipA_N; pfam07805 441952003014 HipA-like C-terminal domain; Region: HipA_C; pfam07804 441952003015 recombination associated protein; Reviewed; Region: rdgC; PRK00321 441952003016 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 441952003017 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 441952003018 active site residue [active] 441952003019 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 441952003020 Part of AAA domain; Region: AAA_19; pfam13245 441952003021 AAA domain; Region: AAA_14; pfam13173 441952003022 Family description; Region: UvrD_C_2; pfam13538 441952003023 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 441952003024 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 441952003025 Isochorismatase family; Region: Isochorismatase; pfam00857 441952003026 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 441952003027 catalytic triad [active] 441952003028 conserved cis-peptide bond; other site 441952003029 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 441952003030 Isochorismatase family; Region: Isochorismatase; pfam00857 441952003031 catalytic triad [active] 441952003032 conserved cis-peptide bond; other site 441952003033 transaldolase-like protein; Provisional; Region: PTZ00411 441952003034 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 441952003035 active site 441952003036 dimer interface [polypeptide binding]; other site 441952003037 catalytic residue [active] 441952003038 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 441952003039 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 441952003040 interface (dimer of trimers) [polypeptide binding]; other site 441952003041 Substrate-binding/catalytic site; other site 441952003042 Zn-binding sites [ion binding]; other site 441952003043 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 441952003044 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 441952003045 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 441952003046 motif 1; other site 441952003047 active site 441952003048 motif 2; other site 441952003049 motif 3; other site 441952003050 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 441952003051 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 441952003052 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 441952003053 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 441952003054 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 441952003055 catalytic residues [active] 441952003056 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 441952003057 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 441952003058 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 441952003059 BCCT family transporter; Region: BCCT; pfam02028 441952003060 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 441952003061 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 441952003062 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 441952003063 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 441952003064 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 441952003065 active site 441952003066 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 441952003067 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 441952003068 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 441952003069 ligand binding site [chemical binding]; other site 441952003070 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 441952003071 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 441952003072 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 441952003073 active site 441952003074 (T/H)XGH motif; other site 441952003075 probable FeS assembly SUF system protein SufT; Region: FeS_long_SufT; TIGR03406 441952003076 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 441952003077 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 441952003078 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 441952003079 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441952003080 catalytic residue [active] 441952003081 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 441952003082 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 441952003083 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 441952003084 Protein of unknown function DUF45; Region: DUF45; pfam01863 441952003085 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 441952003086 Prephenate dehydratase; Region: PDT; pfam00800 441952003087 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 441952003088 putative L-Phe binding site [chemical binding]; other site 441952003089 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 441952003090 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 441952003091 active site 441952003092 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 441952003093 dimer interface [polypeptide binding]; other site 441952003094 substrate binding site [chemical binding]; other site 441952003095 catalytic residues [active] 441952003096 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 441952003097 POT family; Region: PTR2; cl17359 441952003098 GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080 441952003099 putative C-terminal domain interface [polypeptide binding]; other site 441952003100 putative GSH binding site [chemical binding]; other site 441952003101 putative dimer interface [polypeptide binding]; other site 441952003102 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 441952003103 dimer interface [polypeptide binding]; other site 441952003104 substrate binding pocket (H-site) [chemical binding]; other site 441952003105 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 441952003106 putative N-terminal domain interface [polypeptide binding]; other site 441952003107 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 441952003108 hypothetical protein; Provisional; Region: PRK14013 441952003109 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441952003110 motif II; other site 441952003111 POT family; Region: PTR2; cl17359 441952003112 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 441952003113 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441952003114 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 441952003115 DNA binding residues [nucleotide binding] 441952003116 Src Homology 3 domain superfamily; Region: SH3; cl17036 441952003117 peptide ligand binding site [polypeptide binding]; other site 441952003118 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 441952003119 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 441952003120 Protein export membrane protein; Region: SecD_SecF; pfam02355 441952003121 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 441952003122 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 441952003123 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 441952003124 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 441952003125 Isochorismatase family; Region: Isochorismatase; pfam00857 441952003126 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 441952003127 catalytic triad [active] 441952003128 conserved cis-peptide bond; other site 441952003129 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 441952003130 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 441952003131 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 441952003132 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 441952003133 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 441952003134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441952003135 dimer interface [polypeptide binding]; other site 441952003136 conserved gate region; other site 441952003137 ABC-ATPase subunit interface; other site 441952003138 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 441952003139 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 441952003140 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 441952003141 aromatic amino acid transport protein; Region: araaP; TIGR00837 441952003142 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 441952003143 active site residue [active] 441952003144 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 441952003145 active site residue [active] 441952003146 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 441952003147 homotrimer interaction site [polypeptide binding]; other site 441952003148 zinc binding site [ion binding]; other site 441952003149 CDP-binding sites; other site 441952003150 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 441952003151 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 441952003152 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 441952003153 cyanophycin synthetase; Provisional; Region: PRK14016 441952003154 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 441952003155 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 441952003156 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 441952003157 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 441952003158 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 441952003159 active site 441952003160 catalytic site [active] 441952003161 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 441952003162 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 441952003163 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 441952003164 Walker A motif; other site 441952003165 ATP binding site [chemical binding]; other site 441952003166 Walker B motif; other site 441952003167 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 441952003168 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 441952003169 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 441952003170 ferrochelatase; Reviewed; Region: hemH; PRK00035 441952003171 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 441952003172 C-terminal domain interface [polypeptide binding]; other site 441952003173 active site 441952003174 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 441952003175 active site 441952003176 N-terminal domain interface [polypeptide binding]; other site 441952003177 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 441952003178 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 441952003179 GIY-YIG motif/motif A; other site 441952003180 active site 441952003181 catalytic site [active] 441952003182 putative DNA binding site [nucleotide binding]; other site 441952003183 metal binding site [ion binding]; metal-binding site 441952003184 UvrB/uvrC motif; Region: UVR; pfam02151 441952003185 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 441952003186 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 441952003187 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 441952003188 catalytic site [active] 441952003189 putative active site [active] 441952003190 putative substrate binding site [chemical binding]; other site 441952003191 HRDC domain; Region: HRDC; pfam00570 441952003192 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 441952003193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952003194 putative substrate translocation pore; other site 441952003195 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 441952003196 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 441952003197 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 441952003198 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 441952003199 DEAD/DEAH box helicase; Region: DEAD; pfam00270 441952003200 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 441952003201 SEC-C motif; Region: SEC-C; pfam02810 441952003202 LPP20 lipoprotein; Region: LPP20; cl15824 441952003203 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 441952003204 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 441952003205 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441952003206 Walker A motif; other site 441952003207 ATP binding site [chemical binding]; other site 441952003208 Walker B motif; other site 441952003209 arginine finger; other site 441952003210 Peptidase family M41; Region: Peptidase_M41; pfam01434 441952003211 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 441952003212 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 441952003213 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 441952003214 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 441952003215 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 441952003216 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 441952003217 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 441952003218 Type II transport protein GspH; Region: GspH; pfam12019 441952003219 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 441952003220 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 441952003221 active site 441952003222 dimer interface [polypeptide binding]; other site 441952003223 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 441952003224 dimer interface [polypeptide binding]; other site 441952003225 active site 441952003226 Thiamine pyrophosphokinase; Region: TPK; cd07995 441952003227 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 441952003228 active site 441952003229 dimerization interface [polypeptide binding]; other site 441952003230 thiamine binding site [chemical binding]; other site 441952003231 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 441952003232 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 441952003233 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 441952003234 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 441952003235 active site 441952003236 multifunctional aminopeptidase A; Provisional; Region: PRK00913 441952003237 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 441952003238 interface (dimer of trimers) [polypeptide binding]; other site 441952003239 Substrate-binding/catalytic site; other site 441952003240 Zn-binding sites [ion binding]; other site 441952003241 Predicted permeases [General function prediction only]; Region: COG0795 441952003242 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 441952003243 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 441952003244 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 441952003245 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 441952003246 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 441952003247 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 441952003248 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 441952003249 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 441952003250 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 441952003251 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 441952003252 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 441952003253 Predicted membrane protein [Function unknown]; Region: COG2860 441952003254 UPF0126 domain; Region: UPF0126; pfam03458 441952003255 UPF0126 domain; Region: UPF0126; pfam03458 441952003256 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 441952003257 active site 441952003258 dinuclear metal binding site [ion binding]; other site 441952003259 dimerization interface [polypeptide binding]; other site 441952003260 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 441952003261 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 441952003262 active site 441952003263 catalytic motif [active] 441952003264 Zn binding site [ion binding]; other site 441952003265 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 441952003266 FAD binding domain; Region: FAD_binding_4; pfam01565 441952003267 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 441952003268 phosphoglyceromutase; Provisional; Region: PRK05434 441952003269 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 441952003270 seryl-tRNA synthetase; Provisional; Region: PRK05431 441952003271 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 441952003272 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 441952003273 dimer interface [polypeptide binding]; other site 441952003274 active site 441952003275 motif 1; other site 441952003276 motif 2; other site 441952003277 motif 3; other site 441952003278 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 441952003279 ROK family; Region: ROK; pfam00480 441952003280 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 441952003281 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 441952003282 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441952003283 Walker A/P-loop; other site 441952003284 ATP binding site [chemical binding]; other site 441952003285 Q-loop/lid; other site 441952003286 ABC transporter signature motif; other site 441952003287 Walker B; other site 441952003288 D-loop; other site 441952003289 H-loop/switch region; other site 441952003290 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 441952003291 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441952003292 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441952003293 Walker A/P-loop; other site 441952003294 ATP binding site [chemical binding]; other site 441952003295 Q-loop/lid; other site 441952003296 ABC transporter signature motif; other site 441952003297 Walker B; other site 441952003298 D-loop; other site 441952003299 H-loop/switch region; other site 441952003300 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 441952003301 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 441952003302 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 441952003303 homotrimer interaction site [polypeptide binding]; other site 441952003304 putative active site [active] 441952003305 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 441952003306 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 441952003307 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 441952003308 HlyD family secretion protein; Region: HlyD_3; pfam13437 441952003309 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 441952003310 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 441952003311 active site 441952003312 catalytic site [active] 441952003313 metal binding site [ion binding]; metal-binding site 441952003314 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 441952003315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952003316 putative substrate translocation pore; other site 441952003317 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 441952003318 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 441952003319 heme binding site [chemical binding]; other site 441952003320 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 441952003321 dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232 441952003322 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441952003323 Zn2+ binding site [ion binding]; other site 441952003324 Mg2+ binding site [ion binding]; other site 441952003325 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 441952003326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952003327 metabolite-proton symporter; Region: 2A0106; TIGR00883 441952003328 putative substrate translocation pore; other site 441952003329 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 441952003330 putative substrate binding pocket [chemical binding]; other site 441952003331 trimer interface [polypeptide binding]; other site 441952003332 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441952003333 active site 441952003334 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 441952003335 Glyco_18 domain; Region: Glyco_18; smart00636 441952003336 active site 441952003337 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 441952003338 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 441952003339 aromatic chitin/cellulose binding site residues [chemical binding]; other site 441952003340 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 441952003341 aromatic chitin/cellulose binding site residues [chemical binding]; other site 441952003342 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 441952003343 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 441952003344 substrate-cofactor binding pocket; other site 441952003345 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441952003346 catalytic residue [active] 441952003347 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 441952003348 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 441952003349 NAD(P) binding site [chemical binding]; other site 441952003350 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 441952003351 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 441952003352 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 441952003353 substrate binding site; other site 441952003354 dimer interface; other site 441952003355 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 441952003356 Septum formation initiator; Region: DivIC; cl17659 441952003357 enolase; Provisional; Region: eno; PRK00077 441952003358 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 441952003359 dimer interface [polypeptide binding]; other site 441952003360 metal binding site [ion binding]; metal-binding site 441952003361 substrate binding pocket [chemical binding]; other site 441952003362 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441952003363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952003364 putative substrate translocation pore; other site 441952003365 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 441952003366 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 441952003367 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 441952003368 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 441952003369 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 441952003370 nucleotide binding site [chemical binding]; other site 441952003371 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 441952003372 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 441952003373 TRAM domain; Region: TRAM; pfam01938 441952003374 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441952003375 S-adenosylmethionine binding site [chemical binding]; other site 441952003376 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 441952003377 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 441952003378 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 441952003379 ATP-binding site [chemical binding]; other site 441952003380 Sugar specificity; other site 441952003381 Pyrimidine base specificity; other site 441952003382 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 441952003383 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 441952003384 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 441952003385 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 441952003386 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 441952003387 oligomer interface [polypeptide binding]; other site 441952003388 RNA binding site [nucleotide binding]; other site 441952003389 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 441952003390 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 441952003391 RNase E interface [polypeptide binding]; other site 441952003392 trimer interface [polypeptide binding]; other site 441952003393 active site 441952003394 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 441952003395 putative nucleic acid binding region [nucleotide binding]; other site 441952003396 G-X-X-G motif; other site 441952003397 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 441952003398 RNA binding site [nucleotide binding]; other site 441952003399 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 441952003400 16S/18S rRNA binding site [nucleotide binding]; other site 441952003401 S13e-L30e interaction site [polypeptide binding]; other site 441952003402 25S rRNA binding site [nucleotide binding]; other site 441952003403 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 441952003404 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 441952003405 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 441952003406 Cell division protein FtsL; Region: FtsL; cl11433 441952003407 MraW methylase family; Region: Methyltransf_5; cl17771 441952003408 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 441952003409 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 441952003410 AMP-binding enzyme; Region: AMP-binding; pfam00501 441952003411 acyl-activating enzyme (AAE) consensus motif; other site 441952003412 putative AMP binding site [chemical binding]; other site 441952003413 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 441952003414 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 441952003415 DNA binding site [nucleotide binding] 441952003416 catalytic residue [active] 441952003417 H2TH interface [polypeptide binding]; other site 441952003418 putative catalytic residues [active] 441952003419 turnover-facilitating residue; other site 441952003420 intercalation triad [nucleotide binding]; other site 441952003421 8OG recognition residue [nucleotide binding]; other site 441952003422 putative reading head residues; other site 441952003423 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 441952003424 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 441952003425 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 441952003426 predicted active site [active] 441952003427 catalytic triad [active] 441952003428 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 441952003429 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 441952003430 active site 441952003431 multimer interface [polypeptide binding]; other site 441952003432 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 441952003433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441952003434 ATP binding site [chemical binding]; other site 441952003435 Mg2+ binding site [ion binding]; other site 441952003436 G-X-G motif; other site 441952003437 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 441952003438 anchoring element; other site 441952003439 dimer interface [polypeptide binding]; other site 441952003440 ATP binding site [chemical binding]; other site 441952003441 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 441952003442 active site 441952003443 putative metal-binding site [ion binding]; other site 441952003444 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 441952003445 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 441952003446 putative active site pocket [active] 441952003447 dimerization interface [polypeptide binding]; other site 441952003448 putative catalytic residue [active] 441952003449 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 441952003450 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 441952003451 FMN binding site [chemical binding]; other site 441952003452 active site 441952003453 catalytic residues [active] 441952003454 substrate binding site [chemical binding]; other site 441952003455 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 441952003456 TIGR03546 family protein; Region: TIGR03546 441952003457 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 441952003458 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 441952003459 CoA-ligase; Region: Ligase_CoA; pfam00549 441952003460 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 441952003461 CoA binding domain; Region: CoA_binding; smart00881 441952003462 CoA-ligase; Region: Ligase_CoA; pfam00549 441952003463 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 441952003464 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 441952003465 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 441952003466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952003467 putative substrate translocation pore; other site 441952003468 POT family; Region: PTR2; cl17359 441952003469 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 441952003470 active site 441952003471 dimer interface [polypeptide binding]; other site 441952003472 catalytic nucleophile [active] 441952003473 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 441952003474 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 441952003475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952003476 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441952003477 putative substrate translocation pore; other site 441952003478 phosphoglycolate phosphatase; Provisional; Region: PRK13222 441952003479 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441952003480 motif II; other site 441952003481 thioredoxin reductase; Provisional; Region: PRK10262 441952003482 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 441952003483 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441952003484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952003485 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441952003486 putative substrate translocation pore; other site 441952003487 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 441952003488 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441952003489 ATP binding site [chemical binding]; other site 441952003490 Mg2+ binding site [ion binding]; other site 441952003491 G-X-G motif; other site 441952003492 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 441952003493 ATP binding site [chemical binding]; other site 441952003494 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 441952003495 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 441952003496 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 441952003497 Predicted GTPases [General function prediction only]; Region: COG1162 441952003498 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 441952003499 RNA binding site [nucleotide binding]; other site 441952003500 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 441952003501 GTPase/Zn-binding domain interface [polypeptide binding]; other site 441952003502 GTP/Mg2+ binding site [chemical binding]; other site 441952003503 G4 box; other site 441952003504 G5 box; other site 441952003505 G1 box; other site 441952003506 Switch I region; other site 441952003507 G2 box; other site 441952003508 G3 box; other site 441952003509 Switch II region; other site 441952003510 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 441952003511 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 441952003512 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 441952003513 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 441952003514 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 441952003515 Domain of unknown function DUF20; Region: UPF0118; pfam01594 441952003516 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 441952003517 DHH family; Region: DHH; pfam01368 441952003518 DHHA1 domain; Region: DHHA1; pfam02272 441952003519 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 441952003520 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 441952003521 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 441952003522 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 441952003523 motif 1; other site 441952003524 dimer interface [polypeptide binding]; other site 441952003525 active site 441952003526 motif 2; other site 441952003527 motif 3; other site 441952003528 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 441952003529 Mechanosensitive ion channel; Region: MS_channel; pfam00924 441952003530 Helix-turn-helix domain; Region: HTH_25; pfam13413 441952003531 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 441952003532 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 441952003533 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 441952003534 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 441952003535 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 441952003536 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 441952003537 carboxyltransferase (CT) interaction site; other site 441952003538 biotinylation site [posttranslational modification]; other site 441952003539 Dehydroquinase class II; Region: DHquinase_II; pfam01220 441952003540 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 441952003541 trimer interface [polypeptide binding]; other site 441952003542 active site 441952003543 dimer interface [polypeptide binding]; other site 441952003544 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 441952003545 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 441952003546 active site 441952003547 metal binding site [ion binding]; metal-binding site 441952003548 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 441952003549 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 441952003550 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 441952003551 SurA N-terminal domain; Region: SurA_N; pfam09312 441952003552 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 441952003553 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 441952003554 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 441952003555 Organic solvent tolerance protein; Region: OstA_C; pfam04453 441952003556 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 441952003557 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 441952003558 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 441952003559 active site 441952003560 HIGH motif; other site 441952003561 nucleotide binding site [chemical binding]; other site 441952003562 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 441952003563 KMSK motif region; other site 441952003564 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 441952003565 tRNA binding surface [nucleotide binding]; other site 441952003566 anticodon binding site; other site 441952003567 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 441952003568 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 441952003569 dimer interface [polypeptide binding]; other site 441952003570 active site 441952003571 Schiff base residues; other site 441952003572 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 441952003573 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 441952003574 DNA polymerase III subunit delta'; Validated; Region: PRK08485 441952003575 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 441952003576 putative inner membrane peptidase; Provisional; Region: PRK11778 441952003577 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 441952003578 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 441952003579 tandem repeat interface [polypeptide binding]; other site 441952003580 oligomer interface [polypeptide binding]; other site 441952003581 active site residues [active] 441952003582 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 441952003583 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 441952003584 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 441952003585 dimer interface [polypeptide binding]; other site 441952003586 N-terminal domain interface [polypeptide binding]; other site 441952003587 DsrC like protein; Region: DsrC; pfam04358 441952003588 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 441952003589 oxidative damage protection protein; Provisional; Region: PRK05408 441952003590 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 441952003591 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 441952003592 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 441952003593 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 441952003594 Ligand binding site; other site 441952003595 Putative Catalytic site; other site 441952003596 DXD motif; other site 441952003597 Endoplasmic reticulum-based factor for assembly of V-ATPase; Region: Vma12; pfam11712 441952003598 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 441952003599 putative active site [active] 441952003600 YdjC motif; other site 441952003601 Mg binding site [ion binding]; other site 441952003602 putative homodimer interface [polypeptide binding]; other site 441952003603 cell division protein FtsW; Region: ftsW; TIGR02614 441952003604 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 441952003605 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 441952003606 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 441952003607 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 441952003608 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 441952003609 Mg++ binding site [ion binding]; other site 441952003610 putative catalytic motif [active] 441952003611 putative substrate binding site [chemical binding]; other site 441952003612 phosphoenolpyruvate carboxykinase; Provisional; Region: PRK09344 441952003613 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 441952003614 active site 441952003615 metal-binding site [ion binding] 441952003616 nucleotide-binding site [chemical binding]; other site 441952003617 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 441952003618 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 441952003619 active site 441952003620 HIGH motif; other site 441952003621 nucleotide binding site [chemical binding]; other site 441952003622 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 441952003623 KMSKS motif; other site 441952003624 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 441952003625 ABC transporter ATPase component; Reviewed; Region: PRK11147 441952003626 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441952003627 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441952003628 Walker A/P-loop; other site 441952003629 ATP binding site [chemical binding]; other site 441952003630 Q-loop/lid; other site 441952003631 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441952003632 ABC transporter signature motif; other site 441952003633 Walker B; other site 441952003634 D-loop; other site 441952003635 ABC transporter; Region: ABC_tran_2; pfam12848 441952003636 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441952003637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952003638 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441952003639 putative substrate translocation pore; other site 441952003640 Predicted membrane protein [Function unknown]; Region: COG4129 441952003641 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 441952003642 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 441952003643 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441952003644 Coenzyme A binding pocket [chemical binding]; other site 441952003645 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 441952003646 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 441952003647 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 441952003648 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 441952003649 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 441952003650 Ligand binding site; other site 441952003651 Putative Catalytic site; other site 441952003652 DXD motif; other site 441952003653 inner membrane transport permease; Provisional; Region: PRK15066 441952003654 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 441952003655 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 441952003656 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 441952003657 Walker A/P-loop; other site 441952003658 ATP binding site [chemical binding]; other site 441952003659 Q-loop/lid; other site 441952003660 ABC transporter signature motif; other site 441952003661 Walker B; other site 441952003662 D-loop; other site 441952003663 H-loop/switch region; other site 441952003664 hypothetical protein; Provisional; Region: PRK10621 441952003665 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 441952003666 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 441952003667 active site 441952003668 Ferritin-like domain; Region: Ferritin; pfam00210 441952003669 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 441952003670 dinuclear metal binding motif [ion binding]; other site 441952003671 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 441952003672 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 441952003673 dimer interface [polypeptide binding]; other site 441952003674 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 441952003675 exopolyphosphatase; Region: exo_poly_only; TIGR03706 441952003676 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 441952003677 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 441952003678 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 441952003679 catalytic residues [active] 441952003680 transcription termination factor Rho; Provisional; Region: rho; PRK09376 441952003681 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 441952003682 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 441952003683 RNA binding site [nucleotide binding]; other site 441952003684 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 441952003685 multimer interface [polypeptide binding]; other site 441952003686 Walker A motif; other site 441952003687 ATP binding site [chemical binding]; other site 441952003688 Walker B motif; other site 441952003689 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 441952003690 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 441952003691 active site 441952003692 substrate binding site [chemical binding]; other site 441952003693 metal binding site [ion binding]; metal-binding site 441952003694 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 441952003695 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 441952003696 Substrate binding site; other site 441952003697 Cupin domain; Region: Cupin_2; cl17218 441952003698 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 441952003699 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 441952003700 NAD binding site [chemical binding]; other site 441952003701 substrate binding site [chemical binding]; other site 441952003702 homodimer interface [polypeptide binding]; other site 441952003703 active site 441952003704 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 441952003705 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 441952003706 substrate binding site; other site 441952003707 tetramer interface; other site 441952003708 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 441952003709 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 441952003710 active site 441952003711 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 441952003712 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 441952003713 hypothetical protein; Provisional; Region: PRK07579 441952003714 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 441952003715 active site 441952003716 cosubstrate binding site; other site 441952003717 substrate binding site [chemical binding]; other site 441952003718 catalytic site [active] 441952003719 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 441952003720 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 441952003721 inhibitor-cofactor binding pocket; inhibition site 441952003722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441952003723 catalytic residue [active] 441952003724 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 441952003725 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 441952003726 active site 441952003727 dimer interface [polypeptide binding]; other site 441952003728 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 441952003729 Ligand Binding Site [chemical binding]; other site 441952003730 Molecular Tunnel; other site 441952003731 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441952003732 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 441952003733 putative ADP-binding pocket [chemical binding]; other site 441952003734 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 441952003735 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 441952003736 NAD binding site [chemical binding]; other site 441952003737 substrate binding site [chemical binding]; other site 441952003738 homodimer interface [polypeptide binding]; other site 441952003739 active site 441952003740 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 441952003741 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 441952003742 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 441952003743 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441952003744 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 441952003745 putative ADP-binding pocket [chemical binding]; other site 441952003746 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952003747 NADH(P)-binding; Region: NAD_binding_10; pfam13460 441952003748 NAD(P) binding site [chemical binding]; other site 441952003749 active site 441952003750 Bacterial sugar transferase; Region: Bac_transf; pfam02397 441952003751 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 441952003752 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 441952003753 NAD(P) binding site [chemical binding]; other site 441952003754 homodimer interface [polypeptide binding]; other site 441952003755 substrate binding site [chemical binding]; other site 441952003756 active site 441952003757 glutamate dehydrogenase; Provisional; Region: PRK09414 441952003758 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 441952003759 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 441952003760 NAD(P) binding site [chemical binding]; other site 441952003761 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 441952003762 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 441952003763 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 441952003764 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 441952003765 alphaNTD homodimer interface [polypeptide binding]; other site 441952003766 alphaNTD - beta interaction site [polypeptide binding]; other site 441952003767 alphaNTD - beta' interaction site [polypeptide binding]; other site 441952003768 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 441952003769 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 441952003770 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 441952003771 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441952003772 RNA binding surface [nucleotide binding]; other site 441952003773 30S ribosomal protein S11; Validated; Region: PRK05309 441952003774 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 441952003775 30S ribosomal protein S13; Region: bact_S13; TIGR03631 441952003776 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 441952003777 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 441952003778 SecY translocase; Region: SecY; pfam00344 441952003779 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 441952003780 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 441952003781 23S rRNA binding site [nucleotide binding]; other site 441952003782 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 441952003783 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 441952003784 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 441952003785 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 441952003786 23S rRNA interface [nucleotide binding]; other site 441952003787 L21e interface [polypeptide binding]; other site 441952003788 5S rRNA interface [nucleotide binding]; other site 441952003789 L27 interface [polypeptide binding]; other site 441952003790 L5 interface [polypeptide binding]; other site 441952003791 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 441952003792 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 441952003793 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 441952003794 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 441952003795 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 441952003796 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 441952003797 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 441952003798 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 441952003799 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 441952003800 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 441952003801 RNA binding site [nucleotide binding]; other site 441952003802 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 441952003803 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 441952003804 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 441952003805 23S rRNA interface [nucleotide binding]; other site 441952003806 putative translocon interaction site; other site 441952003807 signal recognition particle (SRP54) interaction site; other site 441952003808 L23 interface [polypeptide binding]; other site 441952003809 trigger factor interaction site; other site 441952003810 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 441952003811 23S rRNA interface [nucleotide binding]; other site 441952003812 5S rRNA interface [nucleotide binding]; other site 441952003813 putative antibiotic binding site [chemical binding]; other site 441952003814 L25 interface [polypeptide binding]; other site 441952003815 L27 interface [polypeptide binding]; other site 441952003816 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 441952003817 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 441952003818 G-X-X-G motif; other site 441952003819 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 441952003820 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 441952003821 putative translocon binding site; other site 441952003822 protein-rRNA interface [nucleotide binding]; other site 441952003823 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 441952003824 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 441952003825 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 441952003826 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 441952003827 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 441952003828 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 441952003829 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 441952003830 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 441952003831 elongation factor G; Reviewed; Region: PRK00007 441952003832 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 441952003833 G1 box; other site 441952003834 putative GEF interaction site [polypeptide binding]; other site 441952003835 GTP/Mg2+ binding site [chemical binding]; other site 441952003836 Switch I region; other site 441952003837 G2 box; other site 441952003838 G3 box; other site 441952003839 Switch II region; other site 441952003840 G4 box; other site 441952003841 G5 box; other site 441952003842 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 441952003843 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 441952003844 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 441952003845 30S ribosomal protein S7; Validated; Region: PRK05302 441952003846 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 441952003847 S17 interaction site [polypeptide binding]; other site 441952003848 S8 interaction site; other site 441952003849 16S rRNA interaction site [nucleotide binding]; other site 441952003850 streptomycin interaction site [chemical binding]; other site 441952003851 23S rRNA interaction site [nucleotide binding]; other site 441952003852 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 441952003853 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 441952003854 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 441952003855 trimer interface [polypeptide binding]; other site 441952003856 active site 441952003857 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 441952003858 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 441952003859 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14836 441952003860 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 441952003861 catalytic residue [active] 441952003862 putative FPP diphosphate binding site; other site 441952003863 putative FPP binding hydrophobic cleft; other site 441952003864 dimer interface [polypeptide binding]; other site 441952003865 putative IPP diphosphate binding site; other site 441952003866 ribosome recycling factor; Reviewed; Region: frr; PRK00083 441952003867 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 441952003868 hinge region; other site 441952003869 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 441952003870 putative nucleotide binding site [chemical binding]; other site 441952003871 uridine monophosphate binding site [chemical binding]; other site 441952003872 homohexameric interface [polypeptide binding]; other site 441952003873 elongation factor Ts; Provisional; Region: tsf; PRK09377 441952003874 UBA/TS-N domain; Region: UBA; pfam00627 441952003875 Elongation factor TS; Region: EF_TS; pfam00889 441952003876 Elongation factor TS; Region: EF_TS; pfam00889 441952003877 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 441952003878 rRNA interaction site [nucleotide binding]; other site 441952003879 S8 interaction site; other site 441952003880 putative laminin-1 binding site; other site 441952003881 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 441952003882 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 441952003883 folate binding site [chemical binding]; other site 441952003884 NADP+ binding site [chemical binding]; other site 441952003885 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 441952003886 Amidinotransferase; Region: Amidinotransf; pfam02274 441952003887 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 441952003888 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 441952003889 HIGH motif; other site 441952003890 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 441952003891 active site 441952003892 KMSKS motif; other site 441952003893 fumarate hydratase; Reviewed; Region: fumC; PRK00485 441952003894 Class II fumarases; Region: Fumarase_classII; cd01362 441952003895 active site 441952003896 tetramer interface [polypeptide binding]; other site 441952003897 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 441952003898 dimer interface [polypeptide binding]; other site 441952003899 FMN binding site [chemical binding]; other site 441952003900 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 441952003901 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 441952003902 phosphate binding site [ion binding]; other site 441952003903 1-deoxy-D-xylulose-5-phosphate synthase; Region: PLN02225 441952003904 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 441952003905 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 441952003906 HIGH motif; other site 441952003907 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 441952003908 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 441952003909 active site 441952003910 KMSKS motif; other site 441952003911 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 441952003912 tRNA binding surface [nucleotide binding]; other site 441952003913 anticodon binding site; other site 441952003914 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 441952003915 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 441952003916 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 441952003917 putative substrate binding pocket [chemical binding]; other site 441952003918 AC domain interface; other site 441952003919 catalytic triad [active] 441952003920 AB domain interface; other site 441952003921 interchain disulfide; other site 441952003922 Oxygen tolerance; Region: BatD; pfam13584 441952003923 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441952003924 Tetratricopeptide repeat; Region: TPR_16; pfam13432 441952003925 TPR motif; other site 441952003926 binding surface 441952003927 hypothetical protein; Provisional; Region: PRK13685 441952003928 von Willebrand factor type A domain; Region: VWA_2; pfam13519 441952003929 metal ion-dependent adhesion site (MIDAS); other site 441952003930 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 441952003931 metal ion-dependent adhesion site (MIDAS); other site 441952003932 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 441952003933 Protein of unknown function DUF58; Region: DUF58; pfam01882 441952003934 MoxR-like ATPases [General function prediction only]; Region: COG0714 441952003935 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 441952003936 Walker A motif; other site 441952003937 ATP binding site [chemical binding]; other site 441952003938 Walker B motif; other site 441952003939 arginine finger; other site 441952003940 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 441952003941 pyridoxamine kinase; Validated; Region: PRK05756 441952003942 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 441952003943 dimer interface [polypeptide binding]; other site 441952003944 pyridoxal binding site [chemical binding]; other site 441952003945 ATP binding site [chemical binding]; other site 441952003946 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1244 441952003947 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 441952003948 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 441952003949 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 441952003950 trimer interface [polypeptide binding]; other site 441952003951 active site 441952003952 UDP-GlcNAc binding site [chemical binding]; other site 441952003953 lipid binding site [chemical binding]; lipid-binding site 441952003954 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 441952003955 UbiA prenyltransferase family; Region: UbiA; pfam01040 441952003956 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 441952003957 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 441952003958 Subunit I/III interface [polypeptide binding]; other site 441952003959 Subunit III/IV interface [polypeptide binding]; other site 441952003960 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 441952003961 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 441952003962 D-pathway; other site 441952003963 Putative ubiquinol binding site [chemical binding]; other site 441952003964 Low-spin heme (heme b) binding site [chemical binding]; other site 441952003965 Putative water exit pathway; other site 441952003966 Binuclear center (heme o3/CuB) [ion binding]; other site 441952003967 K-pathway; other site 441952003968 Putative proton exit pathway; other site 441952003969 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 441952003970 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 441952003971 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 441952003972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952003973 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441952003974 putative substrate translocation pore; other site 441952003975 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 441952003976 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 441952003977 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 441952003978 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 441952003979 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 441952003980 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 441952003981 substrate binding pocket [chemical binding]; other site 441952003982 membrane-bound complex binding site; other site 441952003983 hinge residues; other site 441952003984 Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672 441952003985 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 441952003986 RNB domain; Region: RNB; pfam00773 441952003987 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 441952003988 putative hydrolase; Provisional; Region: PRK11460 441952003989 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 441952003990 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 441952003991 domain interfaces; other site 441952003992 active site 441952003993 camphor resistance protein CrcB; Provisional; Region: PRK14226 441952003994 Zinc-finger domain; Region: zf-CHCC; cl01821 441952003995 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 441952003996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441952003997 dimer interface [polypeptide binding]; other site 441952003998 conserved gate region; other site 441952003999 putative PBP binding loops; other site 441952004000 ABC-ATPase subunit interface; other site 441952004001 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441952004002 dimer interface [polypeptide binding]; other site 441952004003 conserved gate region; other site 441952004004 putative PBP binding loops; other site 441952004005 ABC-ATPase subunit interface; other site 441952004006 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 441952004007 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 441952004008 Walker A/P-loop; other site 441952004009 ATP binding site [chemical binding]; other site 441952004010 Q-loop/lid; other site 441952004011 ABC transporter signature motif; other site 441952004012 Walker B; other site 441952004013 D-loop; other site 441952004014 H-loop/switch region; other site 441952004015 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 441952004016 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 441952004017 TrkA-N domain; Region: TrkA_N; pfam02254 441952004018 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 441952004019 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 441952004020 trimer interface [polypeptide binding]; other site 441952004021 putative metal binding site [ion binding]; other site 441952004022 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 441952004023 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 441952004024 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 441952004025 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 441952004026 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 441952004027 Phosphoesterase family; Region: Phosphoesterase; pfam04185 441952004028 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 441952004029 Ligand Binding Site [chemical binding]; other site 441952004030 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 441952004031 Ligand Binding Site [chemical binding]; other site 441952004032 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 441952004033 PLD-like domain; Region: PLDc_2; pfam13091 441952004034 putative homodimer interface [polypeptide binding]; other site 441952004035 putative active site [active] 441952004036 catalytic site [active] 441952004037 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 441952004038 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441952004039 ATP binding site [chemical binding]; other site 441952004040 putative Mg++ binding site [ion binding]; other site 441952004041 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441952004042 nucleotide binding region [chemical binding]; other site 441952004043 ATP-binding site [chemical binding]; other site 441952004044 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 441952004045 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 441952004046 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 441952004047 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 441952004048 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 441952004049 Mitochondrial PGP phosphatase; Region: PGP_phosphatase; pfam09419 441952004050 Predicted methyltransferases [General function prediction only]; Region: COG0313 441952004051 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 441952004052 putative SAM binding site [chemical binding]; other site 441952004053 putative homodimer interface [polypeptide binding]; other site 441952004054 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 441952004055 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 441952004056 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 441952004057 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 441952004058 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 441952004059 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 441952004060 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 441952004061 shikimate binding site; other site 441952004062 NAD(P) binding site [chemical binding]; other site 441952004063 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 441952004064 Ribonuclease P; Region: Ribonuclease_P; pfam00825 441952004065 hypothetical protein; Provisional; Region: PRK14375 441952004066 membrane protein insertase; Provisional; Region: PRK01318 441952004067 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 441952004068 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 441952004069 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 441952004070 putative acyl-acceptor binding pocket; other site 441952004071 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 441952004072 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 441952004073 putative acyl-acceptor binding pocket; other site 441952004074 elongation factor P; Validated; Region: PRK00529 441952004075 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 441952004076 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 441952004077 RNA binding site [nucleotide binding]; other site 441952004078 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 441952004079 RNA binding site [nucleotide binding]; other site 441952004080 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 441952004081 catalytic site [active] 441952004082 putative active site [active] 441952004083 putative substrate binding site [chemical binding]; other site 441952004084 dimer interface [polypeptide binding]; other site 441952004085 pyruvate phosphate dikinase; Provisional; Region: PRK09279 441952004086 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 441952004087 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 441952004088 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 441952004089 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 441952004090 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 441952004091 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 441952004092 G1 box; other site 441952004093 GTP/Mg2+ binding site [chemical binding]; other site 441952004094 Switch I region; other site 441952004095 G2 box; other site 441952004096 G3 box; other site 441952004097 Switch II region; other site 441952004098 G4 box; other site 441952004099 G5 box; other site 441952004100 Nucleoside recognition; Region: Gate; pfam07670 441952004101 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 441952004102 Nucleoside recognition; Region: Gate; pfam07670 441952004103 primosome assembly protein PriA; Validated; Region: PRK05580 441952004104 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441952004105 ATP binding site [chemical binding]; other site 441952004106 putative Mg++ binding site [ion binding]; other site 441952004107 helicase superfamily c-terminal domain; Region: HELICc; smart00490 441952004108 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 441952004109 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 441952004110 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 441952004111 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 441952004112 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 441952004113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952004114 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441952004115 putative substrate translocation pore; other site 441952004116 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 441952004117 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 441952004118 intersubunit interface [polypeptide binding]; other site 441952004119 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 441952004120 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441952004121 Walker A/P-loop; other site 441952004122 ATP binding site [chemical binding]; other site 441952004123 Q-loop/lid; other site 441952004124 ABC transporter signature motif; other site 441952004125 Walker B; other site 441952004126 D-loop; other site 441952004127 H-loop/switch region; other site 441952004128 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 441952004129 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 441952004130 dimer interface [polypeptide binding]; other site 441952004131 putative PBP binding regions; other site 441952004132 ABC-ATPase subunit interface; other site 441952004133 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441952004134 active site 441952004135 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 441952004136 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 441952004137 GDP-binding site [chemical binding]; other site 441952004138 ACT binding site; other site 441952004139 IMP binding site; other site 441952004140 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 441952004141 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 441952004142 purine monophosphate binding site [chemical binding]; other site 441952004143 dimer interface [polypeptide binding]; other site 441952004144 putative catalytic residues [active] 441952004145 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 441952004146 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 441952004147 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 441952004148 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 441952004149 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 441952004150 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 441952004151 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 441952004152 glutamine synthetase; Region: PLN02284 441952004153 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 441952004154 hypothetical protein; Provisional; Region: PRK05208 441952004155 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 441952004156 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 441952004157 dimer interface [polypeptide binding]; other site 441952004158 putative anticodon binding site; other site 441952004159 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 441952004160 motif 1; other site 441952004161 active site 441952004162 motif 2; other site 441952004163 motif 3; other site 441952004164 This domain is found in peptide chain release factors; Region: PCRF; smart00937 441952004165 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 441952004166 RF-1 domain; Region: RF-1; pfam00472 441952004167 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14957 441952004168 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441952004169 Walker A motif; other site 441952004170 ATP binding site [chemical binding]; other site 441952004171 Walker B motif; other site 441952004172 DNA polymerase III subunit delta'; Validated; Region: PRK08485 441952004173 arginine finger; other site 441952004174 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 441952004175 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 441952004176 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 441952004177 cell division protein FtsZ; Validated; Region: PRK09330 441952004178 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 441952004179 nucleotide binding site [chemical binding]; other site 441952004180 SulA interaction site; other site 441952004181 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 441952004182 Cell division protein FtsA; Region: FtsA; smart00842 441952004183 Cell division protein FtsA; Region: FtsA; pfam14450 441952004184 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 441952004185 Cell division protein FtsQ; Region: FtsQ; pfam03799 441952004186 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 441952004187 nucleoside/Zn binding site; other site 441952004188 dimer interface [polypeptide binding]; other site 441952004189 catalytic motif [active] 441952004190 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 441952004191 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 441952004192 RNA binding site [nucleotide binding]; other site 441952004193 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 441952004194 RNA binding site [nucleotide binding]; other site 441952004195 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 441952004196 RNA binding site [nucleotide binding]; other site 441952004197 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 441952004198 RNA binding site [nucleotide binding]; other site 441952004199 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 441952004200 RNA binding site [nucleotide binding]; other site 441952004201 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 441952004202 RNA binding site [nucleotide binding]; other site 441952004203 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 441952004204 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 441952004205 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 441952004206 putative acyl-acceptor binding pocket; other site 441952004207 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 441952004208 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 441952004209 ATP-grasp domain; Region: ATP-grasp_4; cl17255 441952004210 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441952004211 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 441952004212 Walker A/P-loop; other site 441952004213 ATP binding site [chemical binding]; other site 441952004214 Q-loop/lid; other site 441952004215 ABC transporter signature motif; other site 441952004216 Walker B; other site 441952004217 D-loop; other site 441952004218 H-loop/switch region; other site 441952004219 YGGT family; Region: YGGT; pfam02325 441952004220 YGGT family; Region: YGGT; pfam02325 441952004221 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 441952004222 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 441952004223 dimerization interface [polypeptide binding]; other site 441952004224 ATP binding site [chemical binding]; other site 441952004225 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 441952004226 dimerization interface [polypeptide binding]; other site 441952004227 ATP binding site [chemical binding]; other site 441952004228 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 441952004229 putative active site [active] 441952004230 catalytic triad [active] 441952004231 amidophosphoribosyltransferase; Provisional; Region: PRK09246 441952004232 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 441952004233 active site 441952004234 tetramer interface [polypeptide binding]; other site 441952004235 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441952004236 active site 441952004237 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 441952004238 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 441952004239 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 441952004240 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 441952004241 putative protease; Provisional; Region: PRK15452 441952004242 Peptidase family U32; Region: Peptidase_U32; pfam01136 441952004243 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 441952004244 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952004245 putative substrate translocation pore; other site 441952004246 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 441952004247 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 441952004248 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 441952004249 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 441952004250 GTP1/OBG; Region: GTP1_OBG; pfam01018 441952004251 Obg GTPase; Region: Obg; cd01898 441952004252 G1 box; other site 441952004253 GTP/Mg2+ binding site [chemical binding]; other site 441952004254 Switch I region; other site 441952004255 G2 box; other site 441952004256 G3 box; other site 441952004257 Switch II region; other site 441952004258 G4 box; other site 441952004259 G5 box; other site 441952004260 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 441952004261 aromatic amino acid transport protein; Region: araaP; TIGR00837 441952004262 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 441952004263 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 441952004264 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 441952004265 Ligand Binding Site [chemical binding]; other site 441952004266 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 441952004267 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441952004268 dimer interface [polypeptide binding]; other site 441952004269 phosphorylation site [posttranslational modification] 441952004270 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441952004271 ATP binding site [chemical binding]; other site 441952004272 Mg2+ binding site [ion binding]; other site 441952004273 G-X-G motif; other site 441952004274 K+-transporting ATPase, c chain; Region: KdpC; cl00944 441952004275 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 441952004276 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 441952004277 Soluble P-type ATPase [General function prediction only]; Region: COG4087 441952004278 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 441952004279 RNA polymerase beta'' subunit; Reviewed; Region: rpoC2; CHL00117 441952004280 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 441952004281 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 441952004282 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 441952004283 Intracellular growth locus C protein; Region: IglC; pfam11550 441952004284 Protein of unknown function (DUF877); Region: DUF877; pfam05943 441952004285 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 441952004286 type VI secretion protein, VC_A0107 family; Region: VI_chp_5; TIGR03358 441952004287 metabolite-proton symporter; Region: 2A0106; TIGR00883 441952004288 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 441952004289 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 441952004290 dimer interface [polypeptide binding]; other site 441952004291 anticodon binding site; other site 441952004292 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 441952004293 homodimer interface [polypeptide binding]; other site 441952004294 motif 1; other site 441952004295 active site 441952004296 motif 2; other site 441952004297 GAD domain; Region: GAD; pfam02938 441952004298 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 441952004299 active site 441952004300 motif 3; other site 441952004301 phosphate acetyltransferase; Reviewed; Region: PRK05632 441952004302 DRTGG domain; Region: DRTGG; pfam07085 441952004303 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 441952004304 propionate/acetate kinase; Provisional; Region: PRK12379 441952004305 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 441952004306 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 441952004307 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 441952004308 dimer interface [polypeptide binding]; other site 441952004309 ssDNA binding site [nucleotide binding]; other site 441952004310 tetramer (dimer of dimers) interface [polypeptide binding]; other site 441952004311 recombination regulator RecX; Reviewed; Region: recX; PRK00117 441952004312 recombinase A; Provisional; Region: recA; PRK09354 441952004313 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 441952004314 hexamer interface [polypeptide binding]; other site 441952004315 Walker A motif; other site 441952004316 ATP binding site [chemical binding]; other site 441952004317 Walker B motif; other site 441952004318 preprotein translocase subunit SecB; Provisional; Region: PRK13031 441952004319 SecA binding site; other site 441952004320 Preprotein binding site; other site 441952004321 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 441952004322 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 441952004323 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 441952004324 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 441952004325 tandem repeat interface [polypeptide binding]; other site 441952004326 oligomer interface [polypeptide binding]; other site 441952004327 active site residues [active] 441952004328 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 441952004329 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 441952004330 dimer interface [polypeptide binding]; other site 441952004331 PYR/PP interface [polypeptide binding]; other site 441952004332 TPP binding site [chemical binding]; other site 441952004333 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 441952004334 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 441952004335 TPP-binding site [chemical binding]; other site 441952004336 dimer interface [polypeptide binding]; other site 441952004337 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 441952004338 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441952004339 Walker A/P-loop; other site 441952004340 ATP binding site [chemical binding]; other site 441952004341 Q-loop/lid; other site 441952004342 ABC transporter signature motif; other site 441952004343 Walker B; other site 441952004344 D-loop; other site 441952004345 H-loop/switch region; other site 441952004346 ABC transporter; Region: ABC_tran_2; pfam12848 441952004347 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441952004348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952004349 metabolite-proton symporter; Region: 2A0106; TIGR00883 441952004350 putative substrate translocation pore; other site 441952004351 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 441952004352 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 441952004353 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 441952004354 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441952004355 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 441952004356 dimerization interface [polypeptide binding]; other site 441952004357 aminopeptidase N; Provisional; Region: pepN; PRK14015 441952004358 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 441952004359 active site 441952004360 Zn binding site [ion binding]; other site 441952004361 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 441952004362 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 441952004363 putative dimer interface [polypeptide binding]; other site 441952004364 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 441952004365 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 441952004366 active site 441952004367 ribulose/triose binding site [chemical binding]; other site 441952004368 phosphate binding site [ion binding]; other site 441952004369 substrate (anthranilate) binding pocket [chemical binding]; other site 441952004370 product (indole) binding pocket [chemical binding]; other site 441952004371 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 441952004372 active site 441952004373 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 441952004374 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 441952004375 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 441952004376 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 441952004377 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 441952004378 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 441952004379 Glutamine amidotransferase class-I; Region: GATase; pfam00117 441952004380 glutamine binding [chemical binding]; other site 441952004381 catalytic triad [active] 441952004382 anthranilate synthase component I; Provisional; Region: PRK13564 441952004383 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 441952004384 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 441952004385 Trp repressor protein; Region: Trp_repressor; cl17266 441952004386 ribonuclease G; Provisional; Region: PRK11712 441952004387 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 441952004388 homodimer interface [polypeptide binding]; other site 441952004389 oligonucleotide binding site [chemical binding]; other site