-- dump date   	20140619_095941
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
106370000001	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
106370000002	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
106370000003	Walker A motif; other site
106370000004	ATP binding site [chemical binding]; other site
106370000005	Walker B motif; other site
106370000006	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
106370000007	arginine finger; other site
106370000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
106370000009	DnaA box-binding interface [nucleotide binding]; other site
106370000010	DNA polymerase III subunit beta; Validated; Region: PRK07761
106370000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
106370000012	putative DNA binding surface [nucleotide binding]; other site
106370000013	dimer interface [polypeptide binding]; other site
106370000014	beta-clamp/clamp loader binding surface; other site
106370000015	beta-clamp/translesion DNA polymerase binding surface; other site
106370000016	recombination protein F; Reviewed; Region: recF; PRK00064
106370000017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
106370000018	Walker A/P-loop; other site
106370000019	ATP binding site [chemical binding]; other site
106370000020	Q-loop/lid; other site
106370000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
106370000022	ABC transporter signature motif; other site
106370000023	Walker B; other site
106370000024	D-loop; other site
106370000025	H-loop/switch region; other site
106370000026	Protein of unknown function (DUF721); Region: DUF721; cl02324
106370000027	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
106370000028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
106370000029	Mg2+ binding site [ion binding]; other site
106370000030	G-X-G motif; other site
106370000031	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
106370000032	anchoring element; other site
106370000033	dimer interface [polypeptide binding]; other site
106370000034	ATP binding site [chemical binding]; other site
106370000035	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
106370000036	active site
106370000037	putative metal-binding site [ion binding]; other site
106370000038	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
106370000039	DNA gyrase subunit A; Validated; Region: PRK05560
106370000040	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
106370000041	CAP-like domain; other site
106370000042	active site
106370000043	primary dimer interface [polypeptide binding]; other site
106370000044	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
106370000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
106370000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
106370000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
106370000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
106370000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
106370000050	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
106370000051	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
106370000052	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
106370000053	Methyltransferase domain; Region: Methyltransf_31; pfam13847
106370000054	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370000055	S-adenosylmethionine binding site [chemical binding]; other site
106370000056	oligosaccharide amylase; Region: oligosac_amyl; TIGR01577
106370000057	Methyltransferase domain; Region: Methyltransf_24; pfam13578
106370000058	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
106370000059	active site
106370000060	catalytic residues [active]
106370000061	metal binding site [ion binding]; metal-binding site
106370000062	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
106370000063	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
106370000064	DXD motif; other site
106370000065	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
106370000066	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
106370000067	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
106370000068	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
106370000069	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729
106370000070	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731
106370000071	CT1975-like protein; Region: Cas_CT1975; pfam09344
106370000072	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
106370000073	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756
106370000074	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727
106370000075	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719
106370000076	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755
106370000077	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
106370000078	Secretory lipase; Region: LIP; pfam03583
106370000079	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
106370000080	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
106370000081	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
106370000082	Nitrogen regulatory protein P-II; Region: P-II; smart00938
106370000083	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
106370000084	substrate binding site [chemical binding]; other site
106370000085	AAA-like domain; Region: AAA_10; pfam12846
106370000086	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971
106370000087	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
106370000088	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
106370000089	N-acetyl-D-glucosamine binding site [chemical binding]; other site
106370000090	catalytic residue [active]
106370000091	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
106370000092	NlpC/P60 family; Region: NLPC_P60; pfam00877
106370000093	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
106370000094	FAD binding domain; Region: FAD_binding_4; pfam01565
106370000095	Berberine and berberine like; Region: BBE; pfam08031
106370000096	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
106370000097	Catalytic domain of Protein Kinases; Region: PKc; cd00180
106370000098	active site
106370000099	ATP binding site [chemical binding]; other site
106370000100	substrate binding site [chemical binding]; other site
106370000101	activation loop (A-loop); other site
106370000102	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
106370000103	NHL repeat; Region: NHL; pfam01436
106370000104	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
106370000105	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
106370000106	active site
106370000107	dimer interface [polypeptide binding]; other site
106370000108	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
106370000109	dimer interface [polypeptide binding]; other site
106370000110	active site
106370000111	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
106370000112	anti sigma factor interaction site; other site
106370000113	regulatory phosphorylation site [posttranslational modification]; other site
106370000114	Double zinc ribbon; Region: DZR; pfam12773
106370000115	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
106370000116	cyclase homology domain; Region: CHD; cd07302
106370000117	nucleotidyl binding site; other site
106370000118	metal binding site [ion binding]; metal-binding site
106370000119	dimer interface [polypeptide binding]; other site
106370000120	Predicted ATPase [General function prediction only]; Region: COG3899
106370000121	AAA ATPase domain; Region: AAA_16; pfam13191
106370000122	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
106370000123	Walker A/P-loop; other site
106370000124	ATP binding site [chemical binding]; other site
106370000125	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
106370000126	putative FMN binding site [chemical binding]; other site
106370000127	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
106370000128	patatin-related protein; Region: TIGR03607
106370000129	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
106370000130	nucleophile elbow; other site
106370000131	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
106370000132	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
106370000133	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
106370000134	active site
106370000135	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
106370000136	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
106370000137	E3 interaction surface; other site
106370000138	lipoyl attachment site [posttranslational modification]; other site
106370000139	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
106370000140	e3 binding domain; Region: E3_binding; pfam02817
106370000141	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
106370000142	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
106370000143	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
106370000144	alpha subunit interface [polypeptide binding]; other site
106370000145	TPP binding site [chemical binding]; other site
106370000146	heterodimer interface [polypeptide binding]; other site
106370000147	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
106370000148	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
106370000149	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
106370000150	TPP-binding site [chemical binding]; other site
106370000151	tetramer interface [polypeptide binding]; other site
106370000152	heterodimer interface [polypeptide binding]; other site
106370000153	phosphorylation loop region [posttranslational modification]
106370000154	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
106370000155	probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841
106370000156	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
106370000157	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
106370000158	putative active site [active]
106370000159	putative metal binding site [ion binding]; other site
106370000160	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
106370000161	metal binding site 2 [ion binding]; metal-binding site
106370000162	putative DNA binding helix; other site
106370000163	metal binding site 1 [ion binding]; metal-binding site
106370000164	dimer interface [polypeptide binding]; other site
106370000165	structural Zn2+ binding site [ion binding]; other site
106370000166	aminotransferase AlaT; Validated; Region: PRK09265
106370000167	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
106370000168	pyridoxal 5'-phosphate binding site [chemical binding]; other site
106370000169	homodimer interface [polypeptide binding]; other site
106370000170	catalytic residue [active]
106370000171	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
106370000172	Domain of unknown function (DUF222); Region: DUF222; pfam02720
106370000173	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
106370000174	active site
106370000175	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
106370000176	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
106370000177	protein binding site [polypeptide binding]; other site
106370000178	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
106370000179	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
106370000180	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
106370000181	Conserved TM helix; Region: TM_helix; pfam05552
106370000182	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
106370000183	Fe-S cluster binding site [ion binding]; other site
106370000184	active site
106370000185	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
106370000186	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
106370000187	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
106370000188	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
106370000189	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
106370000190	TIR domain; Region: TIR_2; pfam13676
106370000191	citrate synthase 2; Provisional; Region: PRK12350
106370000192	Citrate synthase; Region: Citrate_synt; pfam00285
106370000193	oxalacetate binding site [chemical binding]; other site
106370000194	citrylCoA binding site [chemical binding]; other site
106370000195	coenzyme A binding site [chemical binding]; other site
106370000196	catalytic triad [active]
106370000197	phosphoserine aminotransferase; Provisional; Region: PRK03080
106370000198	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
106370000199	catalytic residue [active]
106370000200	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
106370000201	Citrate synthase; Region: Citrate_synt; pfam00285
106370000202	oxalacetate binding site [chemical binding]; other site
106370000203	citrylCoA binding site [chemical binding]; other site
106370000204	coenzyme A binding site [chemical binding]; other site
106370000205	catalytic triad [active]
106370000206	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
106370000207	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
106370000208	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
106370000209	phosphorylation site [posttranslational modification]
106370000210	intermolecular recognition site; other site
106370000211	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
106370000212	DNA binding residues [nucleotide binding]
106370000213	dimerization interface [polypeptide binding]; other site
106370000214	Histidine kinase; Region: HisKA_3; pfam07730
106370000215	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
106370000216	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
106370000217	MarR family; Region: MarR; pfam01047
106370000218	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
106370000219	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
106370000220	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
106370000221	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
106370000222	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
106370000223	DNA binding site [nucleotide binding]
106370000224	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
106370000225	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
106370000226	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
106370000227	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
106370000228	amidophosphoribosyltransferase; Provisional; Region: PRK07847
106370000229	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
106370000230	active site
106370000231	tetramer interface [polypeptide binding]; other site
106370000232	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
106370000233	active site
106370000234	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
106370000235	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
106370000236	dimerization interface [polypeptide binding]; other site
106370000237	putative ATP binding site [chemical binding]; other site
106370000238	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
106370000239	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
106370000240	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
106370000241	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
106370000242	NAD binding site [chemical binding]; other site
106370000243	Phe binding site; other site
106370000244	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
106370000245	DNA binding residues [nucleotide binding]
106370000246	Transposase domain (DUF772); Region: DUF772; pfam05598
106370000247	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
106370000248	SnoaL-like domain; Region: SnoaL_2; pfam12680
106370000249	DDE superfamily endonuclease; Region: DDE_5; cl17874
106370000250	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
106370000251	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
106370000252	active site
106370000253	Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to  the...; Region: intradiol_dioxygenase_like; cd03457
106370000254	putative active site [active]
106370000255	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
106370000256	Family description; Region: UvrD_C_2; pfam13538
106370000257	Probable transposase; Region: OrfB_IS605; pfam01385
106370000258	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
106370000259	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
106370000260	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
106370000261	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
106370000262	substrate binding pocket [chemical binding]; other site
106370000263	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
106370000264	B12 binding site [chemical binding]; other site
106370000265	cobalt ligand [ion binding]; other site
106370000266	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
106370000267	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
106370000268	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
106370000269	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
106370000270	Int/Topo IB signature motif; other site
106370000271	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
106370000272	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
106370000273	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
106370000274	DNA binding site [nucleotide binding]
106370000275	Int/Topo IB signature motif; other site
106370000276	active site
106370000277	catalytic residues [active]
106370000278	DDE superfamily endonuclease; Region: DDE_3; pfam13358
106370000279	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
106370000280	Winged helix-turn helix; Region: HTH_29; pfam13551
106370000281	Winged helix-turn helix; Region: HTH_33; pfam13592
106370000282	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
106370000283	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
106370000284	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
106370000285	DDE superfamily endonuclease; Region: DDE_4; pfam13359
106370000286	DDE superfamily endonuclease; Region: DDE_5; cl17874
106370000287	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
106370000288	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
106370000289	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
106370000290	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
106370000291	Walker A motif; other site
106370000292	ATP binding site [chemical binding]; other site
106370000293	Walker B motif; other site
106370000294	arginine finger; other site
106370000295	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
106370000296	active site
106370000297	NTP binding site [chemical binding]; other site
106370000298	metal binding triad [ion binding]; metal-binding site
106370000299	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
106370000300	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370000301	non-specific DNA binding site [nucleotide binding]; other site
106370000302	salt bridge; other site
106370000303	sequence-specific DNA binding site [nucleotide binding]; other site
106370000304	Domain of unknown function (DUF955); Region: DUF955; cl01076
106370000305	Transposase; Region: DEDD_Tnp_IS110; pfam01548
106370000306	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
106370000307	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
106370000308	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
106370000309	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676
106370000310	nudix motif; other site
106370000311	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
106370000312	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
106370000313	oligomeric interface; other site
106370000314	putative active site [active]
106370000315	homodimer interface [polypeptide binding]; other site
106370000316	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
106370000317	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
106370000318	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
106370000319	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
106370000320	DDE superfamily endonuclease; Region: DDE_4; pfam13359
106370000321	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
106370000322	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
106370000323	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
106370000324	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
106370000325	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
106370000326	NAD(P) binding site [chemical binding]; other site
106370000327	active site
106370000328	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
106370000329	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
106370000330	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
106370000331	DNA binding site [nucleotide binding]
106370000332	active site
106370000333	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
106370000334	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
106370000335	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
106370000336	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
106370000337	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
106370000338	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
106370000339	DNA binding site [nucleotide binding]
106370000340	active site
106370000341	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
106370000342	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
106370000343	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
106370000344	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
106370000345	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
106370000346	active site
106370000347	NTP binding site [chemical binding]; other site
106370000348	metal binding triad [ion binding]; metal-binding site
106370000349	antibiotic binding site [chemical binding]; other site
106370000350	Protein of unknown function DUF86; Region: DUF86; cl01031
106370000351	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
106370000352	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
106370000353	TPR motif; other site
106370000354	binding surface
106370000355	CHAT domain; Region: CHAT; pfam12770
106370000356	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
106370000357	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
106370000358	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
106370000359	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282
106370000360	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
106370000361	DNA binding residues [nucleotide binding]
106370000362	putative dimer interface [polypeptide binding]; other site
106370000363	Uncharacterized conserved protein [Function unknown]; Region: COG3391
106370000364	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
106370000365	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
106370000366	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
106370000367	NodB motif; other site
106370000368	active site
106370000369	catalytic site [active]
106370000370	metal binding site [ion binding]; metal-binding site
106370000371	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
106370000372	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
106370000373	NodB motif; other site
106370000374	active site
106370000375	catalytic site [active]
106370000376	metal binding site [ion binding]; metal-binding site
106370000377	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
106370000378	active site
106370000379	catalytic triad [active]
106370000380	oxyanion hole [active]
106370000381	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
106370000382	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
106370000383	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
106370000384	NADH(P)-binding; Region: NAD_binding_10; pfam13460
106370000385	NAD binding site [chemical binding]; other site
106370000386	substrate binding site [chemical binding]; other site
106370000387	putative active site [active]
106370000388	Kelch domain; Region: Kelch; smart00612
106370000389	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
106370000390	Kelch motif; Region: Kelch_1; pfam01344
106370000391	Kelch domain; Region: Kelch; smart00612
106370000392	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
106370000393	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
106370000394	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
106370000395	TIGR03086 family protein; Region: TIGR03086
106370000396	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
106370000397	amidase; Provisional; Region: PRK06061
106370000398	Amidase; Region: Amidase; pfam01425
106370000399	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
106370000400	Mechanosensitive ion channel; Region: MS_channel; pfam00924
106370000401	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
106370000402	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
106370000403	catalytic residue [active]
106370000404	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
106370000405	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
106370000406	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
106370000407	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
106370000408	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
106370000409	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
106370000410	catalytic residue [active]
106370000411	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
106370000412	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
106370000413	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
106370000414	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
106370000415	ABC-ATPase subunit interface; other site
106370000416	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
106370000417	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
106370000418	putative PBP binding loops; other site
106370000419	dimer interface [polypeptide binding]; other site
106370000420	ABC-ATPase subunit interface; other site
106370000421	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
106370000422	Walker A/P-loop; other site
106370000423	ATP binding site [chemical binding]; other site
106370000424	ABC transporter; Region: ABC_tran; pfam00005
106370000425	Q-loop/lid; other site
106370000426	ABC transporter signature motif; other site
106370000427	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
106370000428	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
106370000429	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
106370000430	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
106370000431	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
106370000432	[2Fe-2S] cluster binding site [ion binding]; other site
106370000433	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887
106370000434	putative alpha subunit interface [polypeptide binding]; other site
106370000435	putative active site [active]
106370000436	putative substrate binding site [chemical binding]; other site
106370000437	Fe binding site [ion binding]; other site
106370000438	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
106370000439	DDE superfamily endonuclease; Region: DDE_3; pfam13358
106370000440	HsdM N-terminal domain; Region: HsdM_N; pfam12161
106370000441	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
106370000442	Methyltransferase domain; Region: Methyltransf_26; pfam13659
106370000443	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
106370000444	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
106370000445	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
106370000446	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
106370000447	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
106370000448	HlyD family secretion protein; Region: HlyD_3; pfam13437
106370000449	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
106370000450	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
106370000451	FtsX-like permease family; Region: FtsX; pfam02687
106370000452	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
106370000453	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
106370000454	Walker A/P-loop; other site
106370000455	ATP binding site [chemical binding]; other site
106370000456	Q-loop/lid; other site
106370000457	ABC transporter signature motif; other site
106370000458	Walker B; other site
106370000459	D-loop; other site
106370000460	H-loop/switch region; other site
106370000461	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
106370000462	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
106370000463	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
106370000464	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
106370000465	NAD(P) binding site [chemical binding]; other site
106370000466	active site
106370000467	SpaB C-terminal domain; Region: SpaB_C; cl14828
106370000468	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
106370000469	active site
106370000470	zinc binding site [ion binding]; other site
106370000471	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
106370000472	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370000473	salt bridge; other site
106370000474	non-specific DNA binding site [nucleotide binding]; other site
106370000475	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
106370000476	sequence-specific DNA binding site [nucleotide binding]; other site
106370000477	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
106370000478	Predicted flavoprotein [General function prediction only]; Region: COG0431
106370000479	Transcriptional regulators [Transcription]; Region: MarR; COG1846
106370000480	MarR family; Region: MarR_2; pfam12802
106370000481	Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057
106370000482	dimerization interface [polypeptide binding]; other site
106370000483	putative path to active site cavity [active]
106370000484	diiron center [ion binding]; other site
106370000485	Toluene-4-monooxygenase system protein B (TmoB); Region: TmoB; pfam06234
106370000486	Toluene-4-monooxygenase effector protein complex (T4mo), Rieske ferredoxin subunit; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. T4mo is a four-protein complex that catalyzes the NADH- and O2-dependent...; Region: Rieske_T4moC; cd03474
106370000487	[2Fe-2S] cluster binding site [ion binding]; other site
106370000488	MmoB/DmpM family; Region: MmoB_DmpM; pfam02406
106370000489	Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058
106370000490	dimerization interface [polypeptide binding]; other site
106370000491	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
106370000492	active site clefts [active]
106370000493	zinc binding site [ion binding]; other site
106370000494	dimer interface [polypeptide binding]; other site
106370000495	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
106370000496	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
106370000497	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
106370000498	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
106370000499	RNA binding site [nucleotide binding]; other site
106370000500	MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417
106370000501	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
106370000502	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
106370000503	ATP binding site [chemical binding]; other site
106370000504	Mg2+ binding site [ion binding]; other site
106370000505	G-X-G motif; other site
106370000506	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
106370000507	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
106370000508	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
106370000509	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
106370000510	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
106370000511	PGAP1-like protein; Region: PGAP1; pfam07819
106370000512	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
106370000513	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
106370000514	inhibitor-cofactor binding pocket; inhibition site
106370000515	pyridoxal 5'-phosphate binding site [chemical binding]; other site
106370000516	catalytic residue [active]
106370000517	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
106370000518	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
106370000519	NAD(P) binding site [chemical binding]; other site
106370000520	active site
106370000521	UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707
106370000522	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
106370000523	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
106370000524	Domain of unknown function (DUF397); Region: DUF397; pfam04149
106370000525	Helix-turn-helix domain; Region: HTH_31; pfam13560
106370000526	sequence-specific DNA binding site [nucleotide binding]; other site
106370000527	salt bridge; other site
106370000528	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
106370000529	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
106370000530	FAD binding pocket [chemical binding]; other site
106370000531	FAD binding motif [chemical binding]; other site
106370000532	phosphate binding motif [ion binding]; other site
106370000533	beta-alpha-beta structure motif; other site
106370000534	NAD binding pocket [chemical binding]; other site
106370000535	FMN-binding domain; Region: FMN_bind; cl01081
106370000536	ApbE family; Region: ApbE; pfam02424
106370000537	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
106370000538	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
106370000539	active site
106370000540	phosphorylation site [posttranslational modification]
106370000541	intermolecular recognition site; other site
106370000542	dimerization interface [polypeptide binding]; other site
106370000543	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
106370000544	DNA binding site [nucleotide binding]
106370000545	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
106370000546	dimerization interface [polypeptide binding]; other site
106370000547	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
106370000548	dimer interface [polypeptide binding]; other site
106370000549	phosphorylation site [posttranslational modification]
106370000550	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
106370000551	ATP binding site [chemical binding]; other site
106370000552	Mg2+ binding site [ion binding]; other site
106370000553	G-X-G motif; other site
106370000554	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
106370000555	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370000556	S-adenosylmethionine binding site [chemical binding]; other site
106370000557	Common central domain of tyrosinase; Region: Tyrosinase; pfam00264
106370000558	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
106370000559	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
106370000560	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
106370000561	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
106370000562	Walker A/P-loop; other site
106370000563	ATP binding site [chemical binding]; other site
106370000564	ABC transporter; Region: ABC_tran; pfam00005
106370000565	Q-loop/lid; other site
106370000566	ABC transporter signature motif; other site
106370000567	heat shock protein 90; Provisional; Region: PRK05218
106370000568	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
106370000569	ATP binding site [chemical binding]; other site
106370000570	Mg2+ binding site [ion binding]; other site
106370000571	G-X-G motif; other site
106370000572	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
106370000573	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
106370000574	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
106370000575	YCII-related domain; Region: YCII; cl00999
106370000576	Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704
106370000577	DDE superfamily endonuclease; Region: DDE_4; pfam13359
106370000578	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
106370000579	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
106370000580	Walker A/P-loop; other site
106370000581	ATP binding site [chemical binding]; other site
106370000582	Q-loop/lid; other site
106370000583	ABC transporter signature motif; other site
106370000584	Walker B; other site
106370000585	D-loop; other site
106370000586	H-loop/switch region; other site
106370000587	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
106370000588	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
106370000589	putative PBP binding loops; other site
106370000590	dimer interface [polypeptide binding]; other site
106370000591	ABC-ATPase subunit interface; other site
106370000592	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
106370000593	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
106370000594	membrane-bound complex binding site; other site
106370000595	hinge residues; other site
106370000596	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
106370000597	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
106370000598	substrate binding pocket [chemical binding]; other site
106370000599	active site
106370000600	iron coordination sites [ion binding]; other site
106370000601	MarR family; Region: MarR_2; pfam12802
106370000602	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
106370000603	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
106370000604	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
106370000605	Penicillinase repressor; Region: Pencillinase_R; pfam03965
106370000606	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
106370000607	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
106370000608	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
106370000609	CAAX protease self-immunity; Region: Abi; pfam02517
106370000610	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
106370000611	putative active site; other site
106370000612	putative metal binding residues [ion binding]; other site
106370000613	signature motif; other site
106370000614	putative triphosphate binding site [ion binding]; other site
106370000615	CHAD domain; Region: CHAD; pfam05235
106370000616	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
106370000617	DNA-binding site [nucleotide binding]; DNA binding site
106370000618	RNA-binding motif; other site
106370000619	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
106370000620	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
106370000621	aspartate kinase; Reviewed; Region: PRK06635
106370000622	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
106370000623	putative nucleotide binding site [chemical binding]; other site
106370000624	putative catalytic residues [active]
106370000625	putative Mg ion binding site [ion binding]; other site
106370000626	putative aspartate binding site [chemical binding]; other site
106370000627	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
106370000628	putative allosteric regulatory site; other site
106370000629	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
106370000630	putative allosteric regulatory residue; other site
106370000631	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
106370000632	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
106370000633	putative metal binding site [ion binding]; other site
106370000634	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
106370000635	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822
106370000636	putative NAD(P) binding site [chemical binding]; other site
106370000637	putative substrate binding site [chemical binding]; other site
106370000638	catalytic Zn binding site [ion binding]; other site
106370000639	structural Zn binding site [ion binding]; other site
106370000640	recombination protein RecR; Reviewed; Region: recR; PRK00076
106370000641	Helix-hairpin-helix motif; Region: HHH; pfam00633
106370000642	RecR protein; Region: RecR; pfam02132
106370000643	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
106370000644	putative active site [active]
106370000645	putative metal-binding site [ion binding]; other site
106370000646	tetramer interface [polypeptide binding]; other site
106370000647	hypothetical protein; Validated; Region: PRK00153
106370000648	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
106370000649	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
106370000650	Walker A motif; other site
106370000651	ATP binding site [chemical binding]; other site
106370000652	Walker B motif; other site
106370000653	arginine finger; other site
106370000654	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
106370000655	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
106370000656	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
106370000657	TIR domain; Region: TIR_2; pfam13676
106370000658	AAA ATPase domain; Region: AAA_16; pfam13191
106370000659	FOG: WD40 repeat [General function prediction only]; Region: COG2319
106370000660	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
106370000661	structural tetrad; other site
106370000662	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
106370000663	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
106370000664	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
106370000665	Domain of unknown function (DUF4326); Region: DUF4326; pfam14216
106370000666	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
106370000667	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
106370000668	catalytic residue [active]
106370000669	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
106370000670	nucleoside/Zn binding site; other site
106370000671	dimer interface [polypeptide binding]; other site
106370000672	catalytic motif [active]
106370000673	putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941
106370000674	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
106370000675	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
106370000676	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
106370000677	catalytic triad [active]
106370000678	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
106370000679	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
106370000680	NlpC/P60 family; Region: NLPC_P60; pfam00877
106370000681	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
106370000682	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
106370000683	oligomer interface [polypeptide binding]; other site
106370000684	metal binding site [ion binding]; metal-binding site
106370000685	metal binding site [ion binding]; metal-binding site
106370000686	putative Cl binding site [ion binding]; other site
106370000687	basic sphincter; other site
106370000688	hydrophobic gate; other site
106370000689	periplasmic entrance; other site
106370000690	Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567
106370000691	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
106370000692	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
106370000693	active site
106370000694	phosphorylation site [posttranslational modification]
106370000695	intermolecular recognition site; other site
106370000696	dimerization interface [polypeptide binding]; other site
106370000697	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
106370000698	CHASE3 domain; Region: CHASE3; pfam05227
106370000699	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
106370000700	dimerization interface [polypeptide binding]; other site
106370000701	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
106370000702	dimer interface [polypeptide binding]; other site
106370000703	phosphorylation site [posttranslational modification]
106370000704	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
106370000705	ATP binding site [chemical binding]; other site
106370000706	Mg2+ binding site [ion binding]; other site
106370000707	G-X-G motif; other site
106370000708	TIGR03085 family protein; Region: TIGR03085
106370000709	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
106370000710	Interferon-induced transmembrane protein; Region: CD225; pfam04505
106370000711	DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271
106370000712	HSP70 interaction site [polypeptide binding]; other site
106370000713	Interferon-induced transmembrane protein; Region: CD225; pfam04505
106370000714	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
106370000715	DDE superfamily endonuclease; Region: DDE_5; cl17874
106370000716	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
106370000717	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
106370000718	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
106370000719	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
106370000720	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
106370000721	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370000722	non-specific DNA binding site [nucleotide binding]; other site
106370000723	salt bridge; other site
106370000724	sequence-specific DNA binding site [nucleotide binding]; other site
106370000725	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
106370000726	Walker A/P-loop; other site
106370000727	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
106370000728	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
106370000729	active site
106370000730	phosphorylation site [posttranslational modification]
106370000731	intermolecular recognition site; other site
106370000732	dimerization interface [polypeptide binding]; other site
106370000733	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
106370000734	DNA binding residues [nucleotide binding]
106370000735	dimerization interface [polypeptide binding]; other site
106370000736	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
106370000737	Mg2+ binding site [ion binding]; other site
106370000738	Histidine kinase; Region: HisKA_3; pfam07730
106370000739	thymidylate kinase; Validated; Region: PRK07933
106370000740	Fatty acid desaturase; Region: FA_desaturase_2; pfam03405
106370000741	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
106370000742	homodimer interface [polypeptide binding]; other site
106370000743	putative substrate binding pocket [chemical binding]; other site
106370000744	diiron center [ion binding]; other site
106370000745	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
106370000746	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
106370000747	active site
106370000748	phosphorylation site [posttranslational modification]
106370000749	intermolecular recognition site; other site
106370000750	dimerization interface [polypeptide binding]; other site
106370000751	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
106370000752	DNA binding site [nucleotide binding]
106370000753	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
106370000754	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
106370000755	dimerization interface [polypeptide binding]; other site
106370000756	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
106370000757	dimer interface [polypeptide binding]; other site
106370000758	phosphorylation site [posttranslational modification]
106370000759	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
106370000760	ATP binding site [chemical binding]; other site
106370000761	Mg2+ binding site [ion binding]; other site
106370000762	G-X-G motif; other site
106370000763	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
106370000764	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
106370000765	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
106370000766	HTH domain; Region: HTH_11; pfam08279
106370000767	WYL domain; Region: WYL; pfam13280
106370000768	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
106370000769	active site
106370000770	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
106370000771	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
106370000772	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
106370000773	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
106370000774	pyruvate carboxylase; Reviewed; Region: PRK12999
106370000775	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
106370000776	ATP-grasp domain; Region: ATP-grasp_4; cl17255
106370000777	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
106370000778	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
106370000779	active site
106370000780	catalytic residues [active]
106370000781	metal binding site [ion binding]; metal-binding site
106370000782	homodimer binding site [polypeptide binding]; other site
106370000783	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
106370000784	carboxyltransferase (CT) interaction site; other site
106370000785	biotinylation site [posttranslational modification]; other site
106370000786	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
106370000787	DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188
106370000788	Ligand binding site; other site
106370000789	Ligand binding site; other site
106370000790	Ligand binding site; other site
106370000791	Putative Catalytic site; other site
106370000792	DXD motif; other site
106370000793	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
106370000794	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
106370000795	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
106370000796	dimerization interface [polypeptide binding]; other site
106370000797	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
106370000798	dimer interface [polypeptide binding]; other site
106370000799	phosphorylation site [posttranslational modification]
106370000800	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
106370000801	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
106370000802	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
106370000803	active site
106370000804	phosphorylation site [posttranslational modification]
106370000805	intermolecular recognition site; other site
106370000806	dimerization interface [polypeptide binding]; other site
106370000807	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
106370000808	DNA binding site [nucleotide binding]
106370000809	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
106370000810	nucleotide binding site [chemical binding]; other site
106370000811	putative NEF/HSP70 interaction site [polypeptide binding]; other site
106370000812	SBD interface [polypeptide binding]; other site
106370000813	FOG: WD40 repeat [General function prediction only]; Region: COG2319
106370000814	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
106370000815	structural tetrad; other site
106370000816	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
106370000817	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
106370000818	active site
106370000819	phosphorylation site [posttranslational modification]
106370000820	intermolecular recognition site; other site
106370000821	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
106370000822	ATP binding site [chemical binding]; other site
106370000823	Mg2+ binding site [ion binding]; other site
106370000824	G-X-G motif; other site
106370000825	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
106370000826	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
106370000827	metal ion-dependent adhesion site (MIDAS); other site
106370000828	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
106370000829	metal-binding site
106370000830	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
106370000831	MarR family; Region: MarR_2; cl17246
106370000832	Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl17690
106370000833	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
106370000834	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
106370000835	active site
106370000836	metal binding site [ion binding]; metal-binding site
106370000837	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
106370000838	iron-sulfur cluster [ion binding]; other site
106370000839	[2Fe-2S] cluster binding site [ion binding]; other site
106370000840	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
106370000841	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
106370000842	L-asparaginase II; Region: Asparaginase_II; pfam06089
106370000843	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
106370000844	HSP70 interaction site [polypeptide binding]; other site
106370000845	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
106370000846	CoA-transferase family III; Region: CoA_transf_3; pfam02515
106370000847	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
106370000848	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
106370000849	dimerization interface [polypeptide binding]; other site
106370000850	ligand binding site [chemical binding]; other site
106370000851	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
106370000852	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
106370000853	TM-ABC transporter signature motif; other site
106370000854	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
106370000855	TM-ABC transporter signature motif; other site
106370000856	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
106370000857	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
106370000858	Walker A/P-loop; other site
106370000859	ATP binding site [chemical binding]; other site
106370000860	Q-loop/lid; other site
106370000861	ABC transporter signature motif; other site
106370000862	Walker B; other site
106370000863	D-loop; other site
106370000864	H-loop/switch region; other site
106370000865	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
106370000866	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
106370000867	Walker A/P-loop; other site
106370000868	ATP binding site [chemical binding]; other site
106370000869	Q-loop/lid; other site
106370000870	ABC transporter signature motif; other site
106370000871	Walker B; other site
106370000872	D-loop; other site
106370000873	H-loop/switch region; other site
106370000874	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
106370000875	FAD binding domain; Region: FAD_binding_4; pfam01565
106370000876	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
106370000877	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
106370000878	short chain dehydrogenase; Provisional; Region: PRK08219
106370000879	classical (c) SDRs; Region: SDR_c; cd05233
106370000880	NAD(P) binding site [chemical binding]; other site
106370000881	active site
106370000882	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
106370000883	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
106370000884	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
106370000885	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
106370000886	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
106370000887	motif II; other site
106370000888	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
106370000889	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
106370000890	classical (c) SDRs; Region: SDR_c; cd05233
106370000891	NAD(P) binding site [chemical binding]; other site
106370000892	active site
106370000893	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
106370000894	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
106370000895	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
106370000896	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
106370000897	ligand binding site [chemical binding]; other site
106370000898	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370000899	S-adenosylmethionine binding site [chemical binding]; other site
106370000900	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
106370000901	Catalytic domain of Protein Kinases; Region: PKc; cd00180
106370000902	active site
106370000903	ATP binding site [chemical binding]; other site
106370000904	substrate binding site [chemical binding]; other site
106370000905	activation loop (A-loop); other site
106370000906	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
106370000907	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
106370000908	active site
106370000909	ATP binding site [chemical binding]; other site
106370000910	substrate binding site [chemical binding]; other site
106370000911	activation loop (A-loop); other site
106370000912	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
106370000913	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
106370000914	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
106370000915	probable F420-dependent oxidoreductase, MSMEG_3544 family; Region: F420_MSMEG_3544; TIGR03854
106370000916	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
106370000917	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
106370000918	NAD(P) binding site [chemical binding]; other site
106370000919	active site
106370000920	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
106370000921	PAS fold; Region: PAS_3; pfam08447
106370000922	putative active site [active]
106370000923	heme pocket [chemical binding]; other site
106370000924	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
106370000925	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
106370000926	metal binding site [ion binding]; metal-binding site
106370000927	active site
106370000928	I-site; other site
106370000929	PAS fold; Region: PAS; pfam00989
106370000930	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
106370000931	putative active site [active]
106370000932	heme pocket [chemical binding]; other site
106370000933	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
106370000934	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
106370000935	metal binding site [ion binding]; metal-binding site
106370000936	active site
106370000937	I-site; other site
106370000938	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
106370000939	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
106370000940	active site
106370000941	cystathionine gamma-synthase; Provisional; Region: PRK07811
106370000942	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
106370000943	homodimer interface [polypeptide binding]; other site
106370000944	substrate-cofactor binding pocket; other site
106370000945	pyridoxal 5'-phosphate binding site [chemical binding]; other site
106370000946	catalytic residue [active]
106370000947	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
106370000948	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
106370000949	dimer interface [polypeptide binding]; other site
106370000950	pyridoxal 5'-phosphate binding site [chemical binding]; other site
106370000951	catalytic residue [active]
106370000952	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
106370000953	hypothetical protein; Provisional; Region: PRK11770
106370000954	Domain of unknown function (DUF307); Region: DUF307; pfam03733
106370000955	GAF domain; Region: GAF; pfam01590
106370000956	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
106370000957	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
106370000958	metal binding site [ion binding]; metal-binding site
106370000959	active site
106370000960	I-site; other site
106370000961	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
106370000962	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
106370000963	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
106370000964	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
106370000965	Walker A/P-loop; other site
106370000966	ATP binding site [chemical binding]; other site
106370000967	Q-loop/lid; other site
106370000968	ABC transporter signature motif; other site
106370000969	Walker B; other site
106370000970	D-loop; other site
106370000971	H-loop/switch region; other site
106370000972	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
106370000973	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
106370000974	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
106370000975	Walker A/P-loop; other site
106370000976	ATP binding site [chemical binding]; other site
106370000977	Q-loop/lid; other site
106370000978	ABC transporter signature motif; other site
106370000979	Walker B; other site
106370000980	D-loop; other site
106370000981	H-loop/switch region; other site
106370000982	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
106370000983	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
106370000984	putative ligand binding site [chemical binding]; other site
106370000985	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
106370000986	TM-ABC transporter signature motif; other site
106370000987	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
106370000988	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
106370000989	TM-ABC transporter signature motif; other site
106370000990	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
106370000991	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
106370000992	Walker A/P-loop; other site
106370000993	ATP binding site [chemical binding]; other site
106370000994	Q-loop/lid; other site
106370000995	ABC transporter signature motif; other site
106370000996	Walker B; other site
106370000997	D-loop; other site
106370000998	H-loop/switch region; other site
106370000999	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
106370001000	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
106370001001	Walker A/P-loop; other site
106370001002	ATP binding site [chemical binding]; other site
106370001003	Q-loop/lid; other site
106370001004	ABC transporter signature motif; other site
106370001005	Walker B; other site
106370001006	D-loop; other site
106370001007	H-loop/switch region; other site
106370001008	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
106370001009	ThiC-associated domain; Region: ThiC-associated; pfam13667
106370001010	ThiC family; Region: ThiC; pfam01964
106370001011	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
106370001012	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
106370001013	Protein of unknown function (DUF433); Region: DUF433; pfam04255
106370001014	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
106370001015	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
106370001016	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
106370001017	DNA binding site [nucleotide binding]
106370001018	active site
106370001019	Int/Topo IB signature motif; other site
106370001020	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
106370001021	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
106370001022	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370001023	non-specific DNA binding site [nucleotide binding]; other site
106370001024	salt bridge; other site
106370001025	sequence-specific DNA binding site [nucleotide binding]; other site
106370001026	DDE superfamily endonuclease; Region: DDE_5; cl17874
106370001027	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
106370001028	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
106370001029	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
106370001030	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
106370001031	catalytic residues [active]
106370001032	catalytic nucleophile [active]
106370001033	Recombinase; Region: Recombinase; pfam07508
106370001034	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
106370001035	Cupin-like domain; Region: Cupin_8; pfam13621
106370001036	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
106370001037	active site
106370001038	catalytic tetrad [active]
106370001039	Domain of unknown function (DUF397); Region: DUF397; pfam04149
106370001040	Helix-turn-helix domain; Region: HTH_31; pfam13560
106370001041	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
106370001042	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
106370001043	Mg2+ binding site [ion binding]; other site
106370001044	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
106370001045	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
106370001046	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
106370001047	Helix-turn-helix domain; Region: HTH_17; pfam12728
106370001048	Frankia-40 domain; Region: Frankia_40_dom; TIGR03917
106370001049	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
106370001050	DNA binding site [nucleotide binding]
106370001051	active site
106370001052	Int/Topo IB signature motif; other site
106370001053	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
106370001054	Bacterial transcriptional activator domain; Region: BTAD; smart01043
106370001055	Proteins of 100 residues with WXG; Region: WXG100; cl02005
106370001056	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
106370001057	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
106370001058	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
106370001059	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
106370001060	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
106370001061	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
106370001062	active site
106370001063	I-site; other site
106370001064	metal binding site [ion binding]; metal-binding site
106370001065	RyR domain; Region: RyR; pfam02026
106370001066	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
106370001067	TrkA-N domain; Region: TrkA_N; pfam02254
106370001068	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
106370001069	dimer interface [polypeptide binding]; other site
106370001070	putative anticodon binding site; other site
106370001071	tRNA synthetases class II (D, K and N); Region: tRNA-synt_2; pfam00152
106370001072	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
106370001073	motif 1; other site
106370001074	dimer interface [polypeptide binding]; other site
106370001075	active site
106370001076	motif 2; other site
106370001077	motif 3; other site
106370001078	Integrase core domain; Region: rve; pfam00665
106370001079	PII uridylyl-transferase; Provisional; Region: PRK03381
106370001080	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
106370001081	metal binding triad; other site
106370001082	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
106370001083	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
106370001084	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
106370001085	Nitrogen regulatory protein P-II; Region: P-II; smart00938
106370001086	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
106370001087	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
106370001088	NlpC/P60 family; Region: NLPC_P60; pfam00877
106370001089	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
106370001090	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
106370001091	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
106370001092	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
106370001093	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
106370001094	Sulfate transporter family; Region: Sulfate_transp; pfam00916
106370001095	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
106370001096	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
106370001097	dimerization interface [polypeptide binding]; other site
106370001098	putative DNA binding site [nucleotide binding]; other site
106370001099	putative Zn2+ binding site [ion binding]; other site
106370001100	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
106370001101	Dehydroquinase class II; Region: DHquinase_II; pfam01220
106370001102	active site
106370001103	trimer interface [polypeptide binding]; other site
106370001104	dimer interface [polypeptide binding]; other site
106370001105	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
106370001106	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
106370001107	inhibitor-cofactor binding pocket; inhibition site
106370001108	pyridoxal 5'-phosphate binding site [chemical binding]; other site
106370001109	catalytic residue [active]
106370001110	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
106370001111	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
106370001112	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
106370001113	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
106370001114	3-amino-5-hydroxybenoic acid synthesis related protein; Region: AHBA_synth_RP; TIGR01454
106370001115	active site
106370001116	motif I; other site
106370001117	motif II; other site
106370001118	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
106370001119	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
106370001120	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
106370001121	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
106370001122	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
106370001123	shikimate binding site; other site
106370001124	NAD(P) binding site [chemical binding]; other site
106370001125	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
106370001126	dimer interface [polypeptide binding]; other site
106370001127	active site
106370001128	metal binding site [ion binding]; metal-binding site
106370001129	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
106370001130	MarR family; Region: MarR; pfam01047
106370001131	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
106370001132	dimer interface [polypeptide binding]; other site
106370001133	substrate binding site [chemical binding]; other site
106370001134	metal binding site [ion binding]; metal-binding site
106370001135	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
106370001136	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
106370001137	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
106370001138	selenocysteine synthase; Provisional; Region: PRK04311
106370001139	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
106370001140	Frankia-40 domain; Region: Frankia_40_dom; TIGR03917
106370001141	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
106370001142	anti sigma factor interaction site; other site
106370001143	regulatory phosphorylation site [posttranslational modification]; other site
106370001144	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
106370001145	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
106370001146	Coenzyme A binding pocket [chemical binding]; other site
106370001147	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
106370001148	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
106370001149	DNA binding site [nucleotide binding]
106370001150	Ubiquitin-like proteins; Region: UBQ; cl00155
106370001151	charged pocket; other site
106370001152	hydrophobic patch; other site
106370001153	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
106370001154	catalytic residues [active]
106370001155	Domain of unknown function (DUF4395); Region: DUF4395; pfam14340
106370001156	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
106370001157	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
106370001158	active site residue [active]
106370001159	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
106370001160	active site residue [active]
106370001161	Protein of unknown function (DUF1416); Region: DUF1416; pfam07210
106370001162	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
106370001163	heme-binding site [chemical binding]; other site
106370001164	DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453
106370001165	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
106370001166	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
106370001167	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
106370001168	putative ADP-binding pocket [chemical binding]; other site
106370001169	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
106370001170	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
106370001171	active site
106370001172	catalytic tetrad [active]
106370001173	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
106370001174	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370001175	non-specific DNA binding site [nucleotide binding]; other site
106370001176	salt bridge; other site
106370001177	sequence-specific DNA binding site [nucleotide binding]; other site
106370001178	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
106370001179	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
106370001180	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
106370001181	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
106370001182	putative PBP binding loops; other site
106370001183	dimer interface [polypeptide binding]; other site
106370001184	ABC-ATPase subunit interface; other site
106370001185	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
106370001186	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
106370001187	putative PBP binding loops; other site
106370001188	ABC-ATPase subunit interface; other site
106370001189	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
106370001190	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
106370001191	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
106370001192	Walker A/P-loop; other site
106370001193	ATP binding site [chemical binding]; other site
106370001194	Q-loop/lid; other site
106370001195	ABC transporter signature motif; other site
106370001196	Walker B; other site
106370001197	D-loop; other site
106370001198	H-loop/switch region; other site
106370001199	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
106370001200	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
106370001201	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
106370001202	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
106370001203	catalytic core [active]
106370001204	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
106370001205	PhoU domain; Region: PhoU; pfam01895
106370001206	PhoU domain; Region: PhoU; pfam01895
106370001207	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
106370001208	dimer interface [polypeptide binding]; other site
106370001209	phosphorylation site [posttranslational modification]
106370001210	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
106370001211	ATP binding site [chemical binding]; other site
106370001212	Mg2+ binding site [ion binding]; other site
106370001213	G-X-G motif; other site
106370001214	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
106370001215	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
106370001216	active site
106370001217	phosphorylation site [posttranslational modification]
106370001218	intermolecular recognition site; other site
106370001219	dimerization interface [polypeptide binding]; other site
106370001220	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
106370001221	DNA binding site [nucleotide binding]
106370001222	exopolyphosphatase; Region: exo_poly_only; TIGR03706
106370001223	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
106370001224	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
106370001225	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
106370001226	Metal-binding active site; metal-binding site
106370001227	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370001228	S-adenosylmethionine binding site [chemical binding]; other site
106370001229	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
106370001230	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
106370001231	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
106370001232	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
106370001233	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
106370001234	UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240
106370001235	putative NAD(P) binding site [chemical binding]; other site
106370001236	active site
106370001237	putative substrate binding site [chemical binding]; other site
106370001238	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
106370001239	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
106370001240	putative acyl-acceptor binding pocket; other site
106370001241	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
106370001242	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
106370001243	RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2
106370001244	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
106370001245	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
106370001246	DNA binding residues [nucleotide binding]
106370001247	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
106370001248	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
106370001249	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
106370001250	CoA binding domain; Region: CoA_binding; smart00881
106370001251	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
106370001252	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
106370001253	tRNA; other site
106370001254	putative tRNA binding site [nucleotide binding]; other site
106370001255	putative NADP binding site [chemical binding]; other site
106370001256	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
106370001257	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
106370001258	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
106370001259	active site
106370001260	domain interfaces; other site
106370001261	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
106370001262	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
106370001263	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
106370001264	active site
106370001265	delta-aminolevulinic acid dehydratase; Validated; Region: PRK09283
106370001266	dimer interface [polypeptide binding]; other site
106370001267	active site
106370001268	Schiff base residues; other site
106370001269	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
106370001270	metal-binding site [ion binding]
106370001271	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
106370001272	metal-binding site [ion binding]
106370001273	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
106370001274	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
106370001275	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
106370001276	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
106370001277	active site
106370001278	HIGH motif; other site
106370001279	KMSKS motif; other site
106370001280	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
106370001281	tRNA binding surface [nucleotide binding]; other site
106370001282	anticodon binding site; other site
106370001283	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
106370001284	Integrase core domain; Region: rve; pfam00665
106370001285	Integrase core domain; Region: rve_3; cl15866
106370001286	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
106370001287	AAA domain; Region: AAA_22; pfam13401
106370001288	TniQ; Region: TniQ; pfam06527
106370001289	Methyltransferase domain; Region: Methyltransf_23; pfam13489
106370001290	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370001291	S-adenosylmethionine binding site [chemical binding]; other site
106370001292	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
106370001293	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
106370001294	DNA binding residues [nucleotide binding]
106370001295	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
106370001296	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
106370001297	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
106370001298	inhibitor-cofactor binding pocket; inhibition site
106370001299	pyridoxal 5'-phosphate binding site [chemical binding]; other site
106370001300	catalytic residue [active]
106370001301	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
106370001302	catalytic core [active]
106370001303	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
106370001304	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370001305	S-adenosylmethionine binding site [chemical binding]; other site
106370001306	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
106370001307	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
106370001308	catalytic residues [active]
106370001309	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
106370001310	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
106370001311	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
106370001312	ResB-like family; Region: ResB; pfam05140
106370001313	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
106370001314	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
106370001315	menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701
106370001316	prenyltransferase; Reviewed; Region: ubiA; PRK12888
106370001317	UbiA prenyltransferase family; Region: UbiA; pfam01040
106370001318	Flavoprotein; Region: Flavoprotein; pfam02441
106370001319	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
106370001320	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
106370001321	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
106370001322	FeS/SAM binding site; other site
106370001323	Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621
106370001324	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
106370001325	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
106370001326	active site
106370001327	phosphorylation site [posttranslational modification]
106370001328	intermolecular recognition site; other site
106370001329	dimerization interface [polypeptide binding]; other site
106370001330	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
106370001331	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
106370001332	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
106370001333	Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]; Region: SUA7; COG1405
106370001334	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
106370001335	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
106370001336	Active Sites [active]
106370001337	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
106370001338	active site
106370001339	SAM binding site [chemical binding]; other site
106370001340	homodimer interface [polypeptide binding]; other site
106370001341	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
106370001342	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
106370001343	putative active site [active]
106370001344	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
106370001345	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
106370001346	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
106370001347	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
106370001348	Catalytic domain of Protein Kinases; Region: PKc; cd00180
106370001349	active site
106370001350	ATP binding site [chemical binding]; other site
106370001351	substrate binding site [chemical binding]; other site
106370001352	activation loop (A-loop); other site
106370001353	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
106370001354	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
106370001355	FeS/SAM binding site; other site
106370001356	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
106370001357	adenosine deaminase; Provisional; Region: PRK09358
106370001358	active site
106370001359	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
106370001360	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370001361	S-adenosylmethionine binding site [chemical binding]; other site
106370001362	Dienelactone hydrolase family; Region: DLH; pfam01738
106370001363	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
106370001364	NADH dehydrogenase subunit A; Validated; Region: PRK07928
106370001365	NADH dehydrogenase subunit B; Validated; Region: PRK06411
106370001366	NADH dehydrogenase subunit C; Provisional; Region: PRK07785
106370001367	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
106370001368	NADH dehydrogenase subunit D; Validated; Region: PRK06075
106370001369	NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962
106370001370	NADH dehydrogenase subunit E; Validated; Region: PRK07539
106370001371	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
106370001372	putative dimer interface [polypeptide binding]; other site
106370001373	[2Fe-2S] cluster binding site [ion binding]; other site
106370001374	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
106370001375	SLBB domain; Region: SLBB; pfam10531
106370001376	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
106370001377	NADH dehydrogenase subunit G; Validated; Region: PRK07860
106370001378	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
106370001379	catalytic loop [active]
106370001380	iron binding site [ion binding]; other site
106370001381	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
106370001382	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
106370001383	molybdopterin cofactor binding site; other site
106370001384	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
106370001385	molybdopterin cofactor binding site; other site
106370001386	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
106370001387	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
106370001388	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
106370001389	4Fe-4S binding domain; Region: Fer4; pfam00037
106370001390	4Fe-4S binding domain; Region: Fer4; pfam00037
106370001391	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
106370001392	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
106370001393	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
106370001394	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
106370001395	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
106370001396	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
106370001397	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
106370001398	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
106370001399	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
106370001400	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
106370001401	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
106370001402	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
106370001403	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
106370001404	substrate binding pocket [chemical binding]; other site
106370001405	chain length determination region; other site
106370001406	substrate-Mg2+ binding site; other site
106370001407	catalytic residues [active]
106370001408	aspartate-rich region 1; other site
106370001409	active site lid residues [active]
106370001410	aspartate-rich region 2; other site
106370001411	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
106370001412	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
106370001413	TPP-binding site [chemical binding]; other site
106370001414	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
106370001415	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
106370001416	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
106370001417	dimer interface [polypeptide binding]; other site
106370001418	PYR/PP interface [polypeptide binding]; other site
106370001419	TPP binding site [chemical binding]; other site
106370001420	substrate binding site [chemical binding]; other site
106370001421	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
106370001422	heat shock protein HtpX; Provisional; Region: PRK03072
106370001423	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
106370001424	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
106370001425	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
106370001426	active site
106370001427	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
106370001428	putative active site pocket [active]
106370001429	dimerization interface [polypeptide binding]; other site
106370001430	putative catalytic residue [active]
106370001431	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599
106370001432	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
106370001433	active site
106370001434	LGFP repeat; Region: LGFP; pfam08310
106370001435	LGFP repeat; Region: LGFP; pfam08310
106370001436	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
106370001437	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
106370001438	active site
106370001439	catalytic site [active]
106370001440	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
106370001441	active site
106370001442	catalytic site [active]
106370001443	aspartate aminotransferase; Provisional; Region: PRK05764
106370001444	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
106370001445	pyridoxal 5'-phosphate binding site [chemical binding]; other site
106370001446	homodimer interface [polypeptide binding]; other site
106370001447	catalytic residue [active]
106370001448	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
106370001449	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
106370001450	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
106370001451	putative homodimer interface [polypeptide binding]; other site
106370001452	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
106370001453	heterodimer interface [polypeptide binding]; other site
106370001454	homodimer interface [polypeptide binding]; other site
106370001455	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
106370001456	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
106370001457	putative thiostrepton binding site; other site
106370001458	23S rRNA interface [nucleotide binding]; other site
106370001459	L7/L12 interface [polypeptide binding]; other site
106370001460	L25 interface [polypeptide binding]; other site
106370001461	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
106370001462	mRNA/rRNA interface [nucleotide binding]; other site
106370001463	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
106370001464	23S rRNA interface [nucleotide binding]; other site
106370001465	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
106370001466	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
106370001467	core dimer interface [polypeptide binding]; other site
106370001468	peripheral dimer interface [polypeptide binding]; other site
106370001469	L10 interface [polypeptide binding]; other site
106370001470	L11 interface [polypeptide binding]; other site
106370001471	putative EF-Tu interaction site [polypeptide binding]; other site
106370001472	putative EF-G interaction site [polypeptide binding]; other site
106370001473	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
106370001474	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
106370001475	RPB12 interaction site [polypeptide binding]; other site
106370001476	RPB1 interaction site [polypeptide binding]; other site
106370001477	RPB10 interaction site [polypeptide binding]; other site
106370001478	RPB11 interaction site [polypeptide binding]; other site
106370001479	RPB3 interaction site [polypeptide binding]; other site
106370001480	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
106370001481	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
106370001482	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
106370001483	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
106370001484	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
106370001485	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
106370001486	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
106370001487	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
106370001488	G-loop; other site
106370001489	DNA binding site [nucleotide binding]
106370001490	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
106370001491	active site
106370001492	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
106370001493	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
106370001494	active site
106370001495	SUMO-1 interface [polypeptide binding]; other site
106370001496	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
106370001497	S17 interaction site [polypeptide binding]; other site
106370001498	S8 interaction site; other site
106370001499	16S rRNA interaction site [nucleotide binding]; other site
106370001500	streptomycin interaction site [chemical binding]; other site
106370001501	23S rRNA interaction site [nucleotide binding]; other site
106370001502	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
106370001503	30S ribosomal protein S7; Validated; Region: PRK05302
106370001504	elongation factor G; Reviewed; Region: PRK00007
106370001505	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
106370001506	G1 box; other site
106370001507	putative GEF interaction site [polypeptide binding]; other site
106370001508	GTP/Mg2+ binding site [chemical binding]; other site
106370001509	Switch I region; other site
106370001510	G2 box; other site
106370001511	G3 box; other site
106370001512	Switch II region; other site
106370001513	G4 box; other site
106370001514	G5 box; other site
106370001515	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
106370001516	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
106370001517	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
106370001518	elongation factor Tu; Reviewed; Region: PRK00049
106370001519	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
106370001520	G1 box; other site
106370001521	GEF interaction site [polypeptide binding]; other site
106370001522	GTP/Mg2+ binding site [chemical binding]; other site
106370001523	Switch I region; other site
106370001524	G2 box; other site
106370001525	G3 box; other site
106370001526	Switch II region; other site
106370001527	G4 box; other site
106370001528	G5 box; other site
106370001529	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
106370001530	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
106370001531	Antibiotic Binding Site [chemical binding]; other site
106370001532	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
106370001533	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
106370001534	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
106370001535	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
106370001536	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
106370001537	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
106370001538	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
106370001539	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
106370001540	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
106370001541	putative translocon binding site; other site
106370001542	protein-rRNA interface [nucleotide binding]; other site
106370001543	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
106370001544	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
106370001545	G-X-X-G motif; other site
106370001546	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
106370001547	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
106370001548	23S rRNA interface [nucleotide binding]; other site
106370001549	5S rRNA interface [nucleotide binding]; other site
106370001550	putative antibiotic binding site [chemical binding]; other site
106370001551	L25 interface [polypeptide binding]; other site
106370001552	L27 interface [polypeptide binding]; other site
106370001553	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
106370001554	putative translocon interaction site; other site
106370001555	23S rRNA interface [nucleotide binding]; other site
106370001556	signal recognition particle (SRP54) interaction site; other site
106370001557	L23 interface [polypeptide binding]; other site
106370001558	trigger factor interaction site; other site
106370001559	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
106370001560	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
106370001561	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
106370001562	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
106370001563	RNA binding site [nucleotide binding]; other site
106370001564	eIF3G domain found in eukaryotic translation initiation factor 3 subunit G (eIF-3G) and similar proteins; Region: eIF3G; cl13749
106370001565	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
106370001566	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
106370001567	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
106370001568	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
106370001569	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
106370001570	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
106370001571	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
106370001572	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
106370001573	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
106370001574	5S rRNA interface [nucleotide binding]; other site
106370001575	23S rRNA interface [nucleotide binding]; other site
106370001576	L5 interface [polypeptide binding]; other site
106370001577	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
106370001578	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
106370001579	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
106370001580	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
106370001581	23S rRNA binding site [nucleotide binding]; other site
106370001582	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
106370001583	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
106370001584	SecY translocase; Region: SecY; pfam00344
106370001585	adenylate kinase; Reviewed; Region: adk; PRK00279
106370001586	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
106370001587	AMP-binding site [chemical binding]; other site
106370001588	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
106370001589	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
106370001590	active site
106370001591	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
106370001592	rRNA binding site [nucleotide binding]; other site
106370001593	predicted 30S ribosome binding site; other site
106370001594	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
106370001595	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
106370001596	30S ribosomal protein S13; Region: bact_S13; TIGR03631
106370001597	30S ribosomal protein S11; Validated; Region: PRK05309
106370001598	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
106370001599	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
106370001600	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
106370001601	RNA binding surface [nucleotide binding]; other site
106370001602	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
106370001603	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
106370001604	alphaNTD - beta interaction site [polypeptide binding]; other site
106370001605	alphaNTD homodimer interface [polypeptide binding]; other site
106370001606	alphaNTD - beta' interaction site [polypeptide binding]; other site
106370001607	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
106370001608	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
106370001609	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
106370001610	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
106370001611	dimerization interface 3.5A [polypeptide binding]; other site
106370001612	active site
106370001613	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
106370001614	23S rRNA interface [nucleotide binding]; other site
106370001615	L3 interface [polypeptide binding]; other site
106370001616	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
106370001617	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
106370001618	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
106370001619	active site
106370001620	substrate binding site [chemical binding]; other site
106370001621	metal binding site [ion binding]; metal-binding site
106370001622	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
106370001623	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
106370001624	glutaminase active site [active]
106370001625	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
106370001626	dimer interface [polypeptide binding]; other site
106370001627	active site
106370001628	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
106370001629	dimer interface [polypeptide binding]; other site
106370001630	active site
106370001631	Predicted transcriptional regulators [Transcription]; Region: COG1695
106370001632	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
106370001633	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
106370001634	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
106370001635	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
106370001636	substrate binding site [chemical binding]; other site
106370001637	ATP binding site [chemical binding]; other site
106370001638	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
106370001639	alanine racemase; Reviewed; Region: alr; PRK00053
106370001640	active site
106370001641	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
106370001642	dimer interface [polypeptide binding]; other site
106370001643	substrate binding site [chemical binding]; other site
106370001644	catalytic residues [active]
106370001645	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
106370001646	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
106370001647	dimer interface [polypeptide binding]; other site
106370001648	active site
106370001649	glycine-pyridoxal phosphate binding site [chemical binding]; other site
106370001650	folate binding site [chemical binding]; other site
106370001651	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
106370001652	TAP-like protein; Region: Abhydrolase_4; pfam08386
106370001653	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
106370001654	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
106370001655	Glycoprotease family; Region: Peptidase_M22; pfam00814
106370001656	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
106370001657	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
106370001658	Transcriptional regulators [Transcription]; Region: MarR; COG1846
106370001659	MarR family; Region: MarR_2; pfam12802
106370001660	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
106370001661	oligomerisation interface [polypeptide binding]; other site
106370001662	mobile loop; other site
106370001663	roof hairpin; other site
106370001664	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
106370001665	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
106370001666	ring oligomerisation interface [polypeptide binding]; other site
106370001667	ATP/Mg binding site [chemical binding]; other site
106370001668	stacking interactions; other site
106370001669	hinge regions; other site
106370001670	Transcription factor WhiB; Region: Whib; pfam02467
106370001671	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
106370001672	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
106370001673	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
106370001674	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
106370001675	active site
106370001676	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
106370001677	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
106370001678	phosphate binding site [ion binding]; other site
106370001679	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
106370001680	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_4; cd06337
106370001681	putative ligand binding site [chemical binding]; other site
106370001682	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
106370001683	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
106370001684	G1 box; other site
106370001685	GTP/Mg2+ binding site [chemical binding]; other site
106370001686	G2 box; other site
106370001687	Switch I region; other site
106370001688	G3 box; other site
106370001689	Switch II region; other site
106370001690	G4 box; other site
106370001691	G5 box; other site
106370001692	Protein of unknown function (DUF742); Region: DUF742; pfam05331
106370001693	Roadblock/LC7 domain; Region: Robl_LC7; smart00960
106370001694	Nitrate and nitrite sensing; Region: NIT; pfam08376
106370001695	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523
106370001696	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
106370001697	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
106370001698	ATP binding site [chemical binding]; other site
106370001699	Mg2+ binding site [ion binding]; other site
106370001700	G-X-G motif; other site
106370001701	GMP synthase; Reviewed; Region: guaA; PRK00074
106370001702	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
106370001703	AMP/PPi binding site [chemical binding]; other site
106370001704	candidate oxyanion hole; other site
106370001705	catalytic triad [active]
106370001706	potential glutamine specificity residues [chemical binding]; other site
106370001707	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
106370001708	ATP Binding subdomain [chemical binding]; other site
106370001709	Ligand Binding sites [chemical binding]; other site
106370001710	Dimerization subdomain; other site
106370001711	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
106370001712	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
106370001713	catalytic residue [active]
106370001714	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
106370001715	Part of AAA domain; Region: AAA_19; pfam13245
106370001716	Family description; Region: UvrD_C_2; pfam13538
106370001717	Putative serine esterase (DUF676); Region: DUF676; pfam05057
106370001718	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
106370001719	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
106370001720	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
106370001721	active site
106370001722	ATP binding site [chemical binding]; other site
106370001723	substrate binding site [chemical binding]; other site
106370001724	activation loop (A-loop); other site
106370001725	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
106370001726	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
106370001727	CoA-ligase; Region: Ligase_CoA; pfam00549
106370001728	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
106370001729	CoA binding domain; Region: CoA_binding; smart00881
106370001730	CoA-ligase; Region: Ligase_CoA; pfam00549
106370001731	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370001732	non-specific DNA binding site [nucleotide binding]; other site
106370001733	salt bridge; other site
106370001734	sequence-specific DNA binding site [nucleotide binding]; other site
106370001735	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
106370001736	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
106370001737	active site
106370001738	substrate binding site [chemical binding]; other site
106370001739	cosubstrate binding site; other site
106370001740	catalytic site [active]
106370001741	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
106370001742	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
106370001743	purine monophosphate binding site [chemical binding]; other site
106370001744	dimer interface [polypeptide binding]; other site
106370001745	putative catalytic residues [active]
106370001746	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
106370001747	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
106370001748	Protein of unknown function (DUF3017); Region: DUF3017; pfam11222
106370001749	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
106370001750	Beta-lactamase; Region: Beta-lactamase; pfam00144
106370001751	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
106370001752	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
106370001753	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
106370001754	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
106370001755	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
106370001756	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
106370001757	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
106370001758	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
106370001759	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
106370001760	YcfA-like protein; Region: YcfA; pfam07927
106370001761	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
106370001762	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
106370001763	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
106370001764	catalytic residues [active]
106370001765	catalytic nucleophile [active]
106370001766	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
106370001767	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
106370001768	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
106370001769	Fic family protein [Function unknown]; Region: COG3177
106370001770	Fic/DOC family; Region: Fic; pfam02661
106370001771	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
106370001772	clavulanic acid dehydrogenase (CAD), classical (c) SDR; Region: CAD_SDR_c; cd08934
106370001773	NADP binding site [chemical binding]; other site
106370001774	homotetramer interface [polypeptide binding]; other site
106370001775	homodimer interface [polypeptide binding]; other site
106370001776	active site
106370001777	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
106370001778	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
106370001779	ATP binding site [chemical binding]; other site
106370001780	putative Mg++ binding site [ion binding]; other site
106370001781	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
106370001782	nucleotide binding region [chemical binding]; other site
106370001783	ATP-binding site [chemical binding]; other site
106370001784	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
106370001785	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
106370001786	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
106370001787	L-aspartate oxidase; Provisional; Region: PRK06175
106370001788	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
106370001789	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500
106370001790	putative Iron-sulfur protein interface [polypeptide binding]; other site
106370001791	putative proximal heme binding site [chemical binding]; other site
106370001792	putative SdhC-like subunit interface [polypeptide binding]; other site
106370001793	putative distal heme binding site [chemical binding]; other site
106370001794	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501
106370001795	putative Iron-sulfur protein interface [polypeptide binding]; other site
106370001796	putative proximal heme binding site [chemical binding]; other site
106370001797	putative SdhD-like interface [polypeptide binding]; other site
106370001798	putative distal heme binding site [chemical binding]; other site
106370001799	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
106370001800	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
106370001801	active site
106370001802	ATP binding site [chemical binding]; other site
106370001803	substrate binding site [chemical binding]; other site
106370001804	activation loop (A-loop); other site
106370001805	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
106370001806	Catalytic domain of Protein Kinases; Region: PKc; cd00180
106370001807	active site
106370001808	ATP binding site [chemical binding]; other site
106370001809	substrate binding site [chemical binding]; other site
106370001810	activation loop (A-loop); other site
106370001811	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
106370001812	active site
106370001813	catalytic motif [active]
106370001814	Zn binding site [ion binding]; other site
106370001815	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
106370001816	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
106370001817	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
106370001818	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
106370001819	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
106370001820	adenosine deaminase; Provisional; Region: PRK09358
106370001821	active site
106370001822	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
106370001823	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
106370001824	intersubunit interface [polypeptide binding]; other site
106370001825	active site
106370001826	catalytic residue [active]
106370001827	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
106370001828	active site
106370001829	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
106370001830	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
106370001831	active site
106370001832	substrate binding site [chemical binding]; other site
106370001833	metal binding site [ion binding]; metal-binding site
106370001834	purine nucleoside phosphorylase; Provisional; Region: PRK08202
106370001835	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
106370001836	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
106370001837	dimer interface [polypeptide binding]; other site
106370001838	anticodon binding site; other site
106370001839	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
106370001840	motif 1; other site
106370001841	dimer interface [polypeptide binding]; other site
106370001842	active site
106370001843	motif 2; other site
106370001844	GAD domain; Region: GAD; pfam02938
106370001845	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
106370001846	active site
106370001847	motif 3; other site
106370001848	carboxylate-amine ligase; Provisional; Region: PRK13517
106370001849	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
106370001850	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
106370001851	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
106370001852	metal binding site [ion binding]; metal-binding site
106370001853	putative dimer interface [polypeptide binding]; other site
106370001854	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
106370001855	putative active site pocket [active]
106370001856	dimerization interface [polypeptide binding]; other site
106370001857	AIG2-like family; Region: AIG2_2; pfam13772
106370001858	putative catalytic residue [active]
106370001859	flavoprotein disulfide reductase; Reviewed; Region: PRK07845
106370001860	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
106370001861	NAD binding site [chemical binding]; other site
106370001862	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
106370001863	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
106370001864	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
106370001865	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
106370001866	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
106370001867	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
106370001868	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
106370001869	carboxyltransferase (CT) interaction site; other site
106370001870	biotinylation site [posttranslational modification]; other site
106370001871	Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822
106370001872	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
106370001873	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
106370001874	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
106370001875	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
106370001876	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
106370001877	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
106370001878	Bacterial PH domain; Region: DUF304; pfam03703
106370001879	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
106370001880	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
106370001881	Predicted membrane protein [Function unknown]; Region: COG2246
106370001882	GtrA-like protein; Region: GtrA; pfam04138
106370001883	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
106370001884	active site clefts [active]
106370001885	zinc binding site [ion binding]; other site
106370001886	dimer interface [polypeptide binding]; other site
106370001887	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
106370001888	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
106370001889	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
106370001890	TIGR03089 family protein; Region: TIGR03089
106370001891	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
106370001892	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
106370001893	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
106370001894	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
106370001895	G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189
106370001896	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
106370001897	substrate binding site; other site
106370001898	metal-binding site
106370001899	Oligomer interface; other site
106370001900	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
106370001901	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
106370001902	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
106370001903	NADP binding site [chemical binding]; other site
106370001904	active site
106370001905	putative substrate binding site [chemical binding]; other site
106370001906	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
106370001907	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
106370001908	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
106370001909	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
106370001910	putative substrate translocation pore; other site
106370001911	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
106370001912	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
106370001913	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
106370001914	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
106370001915	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
106370001916	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
106370001917	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
106370001918	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
106370001919	Probable Catalytic site; other site
106370001920	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
106370001921	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
106370001922	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
106370001923	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
106370001924	Walker A/P-loop; other site
106370001925	ATP binding site [chemical binding]; other site
106370001926	Q-loop/lid; other site
106370001927	ABC transporter signature motif; other site
106370001928	Walker B; other site
106370001929	D-loop; other site
106370001930	H-loop/switch region; other site
106370001931	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
106370001932	ABC-2 type transporter; Region: ABC2_membrane; cl17235
106370001933	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610
106370001934	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
106370001935	Methyltransferase domain; Region: Methyltransf_24; pfam13578
106370001936	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
106370001937	Catalytic domain of Protein Kinases; Region: PKc; cd00180
106370001938	active site
106370001939	ATP binding site [chemical binding]; other site
106370001940	substrate binding site [chemical binding]; other site
106370001941	activation loop (A-loop); other site
106370001942	FOG: WD40 repeat [General function prediction only]; Region: COG2319
106370001943	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
106370001944	structural tetrad; other site
106370001945	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
106370001946	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
106370001947	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
106370001948	trimer interface [polypeptide binding]; other site
106370001949	active site
106370001950	substrate binding site [chemical binding]; other site
106370001951	CoA binding site [chemical binding]; other site
106370001952	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
106370001953	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
106370001954	Ligand binding site; other site
106370001955	Putative Catalytic site; other site
106370001956	DXD motif; other site
106370001957	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
106370001958	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
106370001959	Methyltransferase domain; Region: Methyltransf_23; pfam13489
106370001960	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370001961	S-adenosylmethionine binding site [chemical binding]; other site
106370001962	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
106370001963	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
106370001964	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
106370001965	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
106370001966	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
106370001967	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
106370001968	Probable Catalytic site; other site
106370001969	metal-binding site
106370001970	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
106370001971	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
106370001972	active site
106370001973	Substrate binding site; other site
106370001974	Mg++ binding site; other site
106370001975	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
106370001976	putative trimer interface [polypeptide binding]; other site
106370001977	putative CoA binding site [chemical binding]; other site
106370001978	DNA polymerase III beta subunit, N-terminal domain; Region: DNA_pol3_beta; pfam00712
106370001979	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
106370001980	DNA polymerase III beta subunit; Region: POL3Bc; smart00480
106370001981	putative DNA binding surface [nucleotide binding]; other site
106370001982	dimer interface [polypeptide binding]; other site
106370001983	beta-clamp/clamp loader binding surface; other site
106370001984	beta-clamp/translesion DNA polymerase binding surface; other site
106370001985	Phosphoesterase family; Region: Phosphoesterase; pfam04185
106370001986	Protein of unknown function (DUF3105); Region: DUF3105; pfam11303
106370001987	F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294
106370001988	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996
106370001989	F420 biosynthesis protein FbiB, C-terminal domain; Region: F420_FbiB_CTERM; TIGR03553
106370001990	dimer interface [polypeptide binding]; other site
106370001991	LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606
106370001992	phosphate binding site [ion binding]; other site
106370001993	dimer interface [polypeptide binding]; other site
106370001994	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
106370001995	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
106370001996	FO synthase; Reviewed; Region: fbiC; PRK09234
106370001997	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
106370001998	FeS/SAM binding site; other site
106370001999	Transcription factor WhiB; Region: Whib; pfam02467
106370002000	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
106370002001	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
106370002002	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
106370002003	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
106370002004	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
106370002005	Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
106370002006	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
106370002007	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
106370002008	active site
106370002009	substrate binding site [chemical binding]; other site
106370002010	metal binding site [ion binding]; metal-binding site
106370002011	Trm112p-like protein; Region: Trm112p; cl01066
106370002012	The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637
106370002013	dimer interface [polypeptide binding]; other site
106370002014	active site
106370002015	Bacterial phospho-glucose isomerase C-terminal region; Region: bact-PGI_C; pfam10432
106370002016	Transglycosylase; Region: Transgly; pfam00912
106370002017	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
106370002018	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
106370002019	Predicted membrane protein/domain [Function unknown]; Region: COG1714
106370002020	Integral membrane protein DUF95; Region: DUF95; pfam01944
106370002021	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
106370002022	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
106370002023	substrate binding pocket [chemical binding]; other site
106370002024	membrane-bound complex binding site; other site
106370002025	hinge residues; other site
106370002026	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
106370002027	Protein of unknown function DUF58; Region: DUF58; pfam01882
106370002028	MoxR-like ATPases [General function prediction only]; Region: COG0714
106370002029	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
106370002030	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
106370002031	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
106370002032	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
106370002033	30S subunit binding site; other site
106370002034	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
106370002035	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
106370002036	active site
106370002037	phosphorylation site [posttranslational modification]
106370002038	intermolecular recognition site; other site
106370002039	dimerization interface [polypeptide binding]; other site
106370002040	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
106370002041	DNA binding residues [nucleotide binding]
106370002042	dimerization interface [polypeptide binding]; other site
106370002043	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
106370002044	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
106370002045	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
106370002046	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
106370002047	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
106370002048	SEC-C motif; Region: SEC-C; pfam02810
106370002049	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
106370002050	Helix-turn-helix domain; Region: HTH_17; pfam12728
106370002051	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
106370002052	AAA domain; Region: AAA_31; pfam13614
106370002053	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
106370002054	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370002055	non-specific DNA binding site [nucleotide binding]; other site
106370002056	salt bridge; other site
106370002057	sequence-specific DNA binding site [nucleotide binding]; other site
106370002058	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
106370002059	Uncharacterized conserved protein [Function unknown]; Region: COG3743
106370002060	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
106370002061	PAS domain; Region: PAS_9; pfam13426
106370002062	putative active site [active]
106370002063	heme pocket [chemical binding]; other site
106370002064	PAS fold; Region: PAS_7; pfam12860
106370002065	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
106370002066	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
106370002067	ATP binding site [chemical binding]; other site
106370002068	Walker A motif; other site
106370002069	hexamer interface [polypeptide binding]; other site
106370002070	Walker B motif; other site
106370002071	Tetratricopeptide repeat; Region: TPR_12; pfam13424
106370002072	Phosphotransferase enzyme family; Region: APH; pfam01636
106370002073	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
106370002074	substrate binding site [chemical binding]; other site
106370002075	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
106370002076	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
106370002077	peptide chain release factor 2; Validated; Region: prfB; PRK00578
106370002078	This domain is found in peptide chain release factors; Region: PCRF; smart00937
106370002079	RF-1 domain; Region: RF-1; pfam00472
106370002080	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
106370002081	putative active site [active]
106370002082	putative metal binding site [ion binding]; other site
106370002083	bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239
106370002084	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
106370002085	active site
106370002086	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
106370002087	DNA binding site [nucleotide binding]
106370002088	nitrite reductase subunit NirD; Provisional; Region: PRK14989
106370002089	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
106370002090	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
106370002091	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
106370002092	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
106370002093	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
106370002094	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
106370002095	homodimer interface [polypeptide binding]; other site
106370002096	active site
106370002097	SAM binding site [chemical binding]; other site
106370002098	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
106370002099	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
106370002100	Walker A/P-loop; other site
106370002101	ATP binding site [chemical binding]; other site
106370002102	Q-loop/lid; other site
106370002103	ABC transporter signature motif; other site
106370002104	Walker B; other site
106370002105	D-loop; other site
106370002106	H-loop/switch region; other site
106370002107	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
106370002108	FtsX-like permease family; Region: FtsX; pfam02687
106370002109	Domain of unknown function (DUF222); Region: DUF222; pfam02720
106370002110	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
106370002111	active site
106370002112	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
106370002113	SmpB-tmRNA interface; other site
106370002114	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
106370002115	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
106370002116	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
106370002117	The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6,  and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348
106370002118	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
106370002119	putative active site [active]
106370002120	putative metal binding site [ion binding]; other site
106370002121	Domain of unknown function (DUF4037); Region: DUF4037; pfam13228
106370002122	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370002123	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
106370002124	non-specific DNA binding site [nucleotide binding]; other site
106370002125	salt bridge; other site
106370002126	sequence-specific DNA binding site [nucleotide binding]; other site
106370002127	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
106370002128	Antirestriction protein (ArdA); Region: ArdA; cl01953
106370002129	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
106370002130	DNA-binding interface [nucleotide binding]; DNA binding site
106370002131	Predicted transcriptional regulators [Transcription]; Region: COG1695
106370002132	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
106370002133	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
106370002134	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
106370002135	Walker A/P-loop; other site
106370002136	ATP binding site [chemical binding]; other site
106370002137	Q-loop/lid; other site
106370002138	ABC transporter signature motif; other site
106370002139	Walker B; other site
106370002140	D-loop; other site
106370002141	H-loop/switch region; other site
106370002142	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
106370002143	UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240
106370002144	putative NAD(P) binding site [chemical binding]; other site
106370002145	active site
106370002146	putative substrate binding site [chemical binding]; other site
106370002147	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
106370002148	nudix motif; other site
106370002149	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
106370002150	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
106370002151	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
106370002152	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
106370002153	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
106370002154	NAD(P) binding site [chemical binding]; other site
106370002155	active site
106370002156	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
106370002157	active site lid residues [active]
106370002158	substrate binding pocket [chemical binding]; other site
106370002159	catalytic residues [active]
106370002160	substrate-Mg2+ binding site; other site
106370002161	aspartate-rich region 1; other site
106370002162	aspartate-rich region 2; other site
106370002163	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
106370002164	active site lid residues [active]
106370002165	substrate binding pocket [chemical binding]; other site
106370002166	catalytic residues [active]
106370002167	substrate-Mg2+ binding site; other site
106370002168	aspartate-rich region 1; other site
106370002169	aspartate-rich region 2; other site
106370002170	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
106370002171	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
106370002172	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
106370002173	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
106370002174	substrate binding pocket [chemical binding]; other site
106370002175	chain length determination region; other site
106370002176	substrate-Mg2+ binding site; other site
106370002177	catalytic residues [active]
106370002178	aspartate-rich region 1; other site
106370002179	active site lid residues [active]
106370002180	aspartate-rich region 2; other site
106370002181	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
106370002182	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
106370002183	Active site cavity [active]
106370002184	catalytic acid [active]
106370002185	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
106370002186	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
106370002187	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
106370002188	Predicted transcriptional regulators [Transcription]; Region: COG1733
106370002189	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
106370002190	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
106370002191	CoenzymeA binding site [chemical binding]; other site
106370002192	subunit interaction site [polypeptide binding]; other site
106370002193	PHB binding site; other site
106370002194	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
106370002195	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
106370002196	FeS/SAM binding site; other site
106370002197	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
106370002198	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
106370002199	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
106370002200	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
106370002201	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
106370002202	active site
106370002203	UreD urease accessory protein; Region: UreD; cl00530
106370002204	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
106370002205	UreF; Region: UreF; pfam01730
106370002206	urease subunit alpha; Reviewed; Region: ureC; PRK13206
106370002207	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
106370002208	subunit interactions [polypeptide binding]; other site
106370002209	active site
106370002210	flap region; other site
106370002211	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
106370002212	gamma-beta subunit interface [polypeptide binding]; other site
106370002213	alpha-beta subunit interface [polypeptide binding]; other site
106370002214	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
106370002215	alpha-gamma subunit interface [polypeptide binding]; other site
106370002216	beta-gamma subunit interface [polypeptide binding]; other site
106370002217	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
106370002218	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
106370002219	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
106370002220	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
106370002221	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
106370002222	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
106370002223	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
106370002224	4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193
106370002225	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
106370002226	xanthine dehydrogenase D subunit; Region: pucD; TIGR03196
106370002227	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
106370002228	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
106370002229	allantoinase; Region: allantoinase; TIGR03178
106370002230	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
106370002231	active site
106370002232	putative bifunctional allantoicase/OHCU decarboxylase; Provisional; Region: PRK13797
106370002233	Allantoicase repeat; Region: Allantoicase; pfam03561
106370002234	Allantoicase repeat; Region: Allantoicase; pfam03561
106370002235	OHCU decarboxylase; Region: UraD_2; TIGR03180
106370002236	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
106370002237	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
106370002238	active site
106370002239	homotetramer interface [polypeptide binding]; other site
106370002240	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
106370002241	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
106370002242	active site
106370002243	putative substrate binding pocket [chemical binding]; other site
106370002244	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
106370002245	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
106370002246	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
106370002247	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
106370002248	agmatinase; Region: agmatinase; TIGR01230
106370002249	Agmatinase-like family; Region: Agmatinase-like; cd09990
106370002250	active site
106370002251	oligomer interface [polypeptide binding]; other site
106370002252	Mn binding site [ion binding]; other site
106370002253	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
106370002254	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
106370002255	putative ligand binding site [chemical binding]; other site
106370002256	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
106370002257	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
106370002258	Walker A/P-loop; other site
106370002259	ATP binding site [chemical binding]; other site
106370002260	Q-loop/lid; other site
106370002261	ABC transporter signature motif; other site
106370002262	Walker B; other site
106370002263	D-loop; other site
106370002264	H-loop/switch region; other site
106370002265	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
106370002266	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
106370002267	Walker A/P-loop; other site
106370002268	ATP binding site [chemical binding]; other site
106370002269	Q-loop/lid; other site
106370002270	ABC transporter signature motif; other site
106370002271	Walker B; other site
106370002272	D-loop; other site
106370002273	H-loop/switch region; other site
106370002274	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
106370002275	TM-ABC transporter signature motif; other site
106370002276	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
106370002277	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
106370002278	TM-ABC transporter signature motif; other site
106370002279	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
106370002280	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
106370002281	NAD(P) binding site [chemical binding]; other site
106370002282	active site
106370002283	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
106370002284	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370002285	non-specific DNA binding site [nucleotide binding]; other site
106370002286	salt bridge; other site
106370002287	sequence-specific DNA binding site [nucleotide binding]; other site
106370002288	Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488
106370002289	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
106370002290	active site
106370002291	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
106370002292	nudix motif; other site
106370002293	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
106370002294	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
106370002295	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
106370002296	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
106370002297	[4Fe-4S] binding site [ion binding]; other site
106370002298	molybdopterin cofactor binding site; other site
106370002299	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
106370002300	molybdopterin cofactor binding site; other site
106370002301	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
106370002302	Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
106370002303	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
106370002304	MPN+ (JAMM) motif; other site
106370002305	Zinc-binding site [ion binding]; other site
106370002306	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
106370002307	MoaE interaction surface [polypeptide binding]; other site
106370002308	MoeB interaction surface [polypeptide binding]; other site
106370002309	thiocarboxylated glycine; other site
106370002310	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
106370002311	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
106370002312	dimer interface [polypeptide binding]; other site
106370002313	pyridoxal 5'-phosphate binding site [chemical binding]; other site
106370002314	catalytic residue [active]
106370002315	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
106370002316	active site
106370002317	dimerization interface [polypeptide binding]; other site
106370002318	ribonuclease PH; Reviewed; Region: rph; PRK00173
106370002319	Ribonuclease PH; Region: RNase_PH_bact; cd11362
106370002320	hexamer interface [polypeptide binding]; other site
106370002321	active site
106370002322	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
106370002323	glutamate racemase; Provisional; Region: PRK00865
106370002324	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
106370002325	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
106370002326	Uncharacterized conserved protein [Function unknown]; Region: COG1359
106370002327	TIR domain; Region: TIR_2; pfam13676
106370002328	Tetratricopeptide repeat; Region: TPR_12; pfam13424
106370002329	Tetratricopeptide repeat; Region: TPR_12; pfam13424
106370002330	Tetratricopeptide repeat; Region: TPR_10; pfam13374
106370002331	Tetratricopeptide repeat; Region: TPR_12; pfam13424
106370002332	Tetratricopeptide repeat; Region: TPR_10; pfam13374
106370002333	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
106370002334	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
106370002335	Int/Topo IB signature motif; other site
106370002336	Antirestriction protein (ArdA); Region: ArdA; pfam07275
106370002337	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
106370002338	Domain of unknown function (DUF955); Region: DUF955; pfam06114
106370002339	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
106370002340	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370002341	non-specific DNA binding site [nucleotide binding]; other site
106370002342	salt bridge; other site
106370002343	sequence-specific DNA binding site [nucleotide binding]; other site
106370002344	Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452
106370002345	hypothetical protein; Provisional; Region: PRK06153
106370002346	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
106370002347	ATP binding site [chemical binding]; other site
106370002348	substrate interface [chemical binding]; other site
106370002349	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
106370002350	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370002351	non-specific DNA binding site [nucleotide binding]; other site
106370002352	salt bridge; other site
106370002353	sequence-specific DNA binding site [nucleotide binding]; other site
106370002354	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
106370002355	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
106370002356	TAP-like protein; Region: Abhydrolase_4; pfam08386
106370002357	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
106370002358	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
106370002359	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
106370002360	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370002361	sequence-specific DNA binding site [nucleotide binding]; other site
106370002362	salt bridge; other site
106370002363	AAA domain; Region: AAA_17; cl17253
106370002364	adenylate kinase; Region: adk; TIGR01351
106370002365	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
106370002366	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
106370002367	FeS/SAM binding site; other site
106370002368	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
106370002369	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
106370002370	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
106370002371	substrate binding site [chemical binding]; other site
106370002372	ATP binding site [chemical binding]; other site
106370002373	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
106370002374	ATP binding site [chemical binding]; other site
106370002375	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683
106370002376	nudix motif; other site
106370002377	AAA ATPase domain; Region: AAA_16; pfam13191
106370002378	AAA-like domain; Region: AAA_10; pfam12846
106370002379	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
106370002380	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
106370002381	Replication-relaxation; Region: Replic_Relax; pfam13814
106370002382	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
106370002383	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370002384	non-specific DNA binding site [nucleotide binding]; other site
106370002385	salt bridge; other site
106370002386	sequence-specific DNA binding site [nucleotide binding]; other site
106370002387	Domain of unknown function (DUF955); Region: DUF955; pfam06114
106370002388	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
106370002389	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
106370002390	catalytic residues [active]
106370002391	catalytic nucleophile [active]
106370002392	Recombinase; Region: Recombinase; pfam07508
106370002393	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
106370002394	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
106370002395	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
106370002396	catalytic triad [active]
106370002397	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
106370002398	Thioredoxin; Region: Thioredoxin_4; pfam13462
106370002399	Methylamine utilisation protein MauE; Region: MauE; pfam07291
106370002400	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
106370002401	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
106370002402	Cu(I) binding site [ion binding]; other site
106370002403	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
106370002404	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
106370002405	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
106370002406	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
106370002407	ATP binding site [chemical binding]; other site
106370002408	Mg2+ binding site [ion binding]; other site
106370002409	G-X-G motif; other site
106370002410	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
106370002411	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
106370002412	oligomerisation interface [polypeptide binding]; other site
106370002413	mobile loop; other site
106370002414	roof hairpin; other site
106370002415	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
106370002416	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
106370002417	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
106370002418	DNA binding residues [nucleotide binding]
106370002419	dimerization interface [polypeptide binding]; other site
106370002420	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
106370002421	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
106370002422	DNA binding residues [nucleotide binding]
106370002423	dimerization interface [polypeptide binding]; other site
106370002424	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
106370002425	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
106370002426	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
106370002427	phosphate binding site [ion binding]; other site
106370002428	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
106370002429	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
106370002430	active site
106370002431	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
106370002432	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
106370002433	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
106370002434	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
106370002435	putative NADP binding site [chemical binding]; other site
106370002436	active site
106370002437	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
106370002438	Beta-ketoacyl synthase, N-terminal domain; Region: ketoacyl-synt; pfam00109
106370002439	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
106370002440	active site
106370002441	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
106370002442	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
106370002443	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
106370002444	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
106370002445	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
106370002446	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
106370002447	glycosyltransferase, MGT family; Region: MGT; TIGR01426
106370002448	active site
106370002449	TDP-binding site; other site
106370002450	acceptor substrate-binding pocket; other site
106370002451	Methyltransferase domain; Region: Methyltransf_23; pfam13489
106370002452	Methyltransferase domain; Region: Methyltransf_12; pfam08242
106370002453	Domain of unknown function DUF87; Region: DUF87; pfam01935
106370002454	AAA-like domain; Region: AAA_10; pfam12846
106370002455	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
106370002456	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
106370002457	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
106370002458	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
106370002459	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
106370002460	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
106370002461	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
106370002462	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
106370002463	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
106370002464	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
106370002465	active site
106370002466	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
106370002467	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
106370002468	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
106370002469	active site
106370002470	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
106370002471	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
106370002472	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
106370002473	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
106370002474	FAD binding domain; Region: FAD_binding_4; pfam01565
106370002475	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
106370002476	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
106370002477	NAD(P) binding site [chemical binding]; other site
106370002478	active site
106370002479	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
106370002480	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
106370002481	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
106370002482	phosphopeptide binding site; other site
106370002483	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
106370002484	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
106370002485	phosphopeptide binding site; other site
106370002486	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
106370002487	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
106370002488	Walker A/P-loop; other site
106370002489	ATP binding site [chemical binding]; other site
106370002490	Q-loop/lid; other site
106370002491	ABC transporter signature motif; other site
106370002492	Walker B; other site
106370002493	D-loop; other site
106370002494	H-loop/switch region; other site
106370002495	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
106370002496	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
106370002497	Catalytic domain of Protein Kinases; Region: PKc; cd00180
106370002498	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
106370002499	active site
106370002500	ATP binding site [chemical binding]; other site
106370002501	substrate binding site [chemical binding]; other site
106370002502	activation loop (A-loop); other site
106370002503	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
106370002504	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
106370002505	hypothetical protein; Provisional; Region: PRK07877
106370002506	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
106370002507	endonuclease III; Region: ENDO3c; smart00478
106370002508	minor groove reading motif; other site
106370002509	helix-hairpin-helix signature motif; other site
106370002510	intracellular protease, PfpI family; Region: PfpI; TIGR01382
106370002511	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
106370002512	proposed catalytic triad [active]
106370002513	conserved cys residue [active]
106370002514	Part of AAA domain; Region: AAA_19; pfam13245
106370002515	DDE superfamily endonuclease; Region: DDE_3; pfam13358
106370002516	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
106370002517	HTH domain; Region: HTH_11; pfam08279
106370002518	Protein of unknown function (DUF433); Region: DUF433; cl01030
106370002519	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
106370002520	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
106370002521	Helix-turn-helix domain; Region: HTH_38; pfam13936
106370002522	DDE superfamily endonuclease; Region: DDE_4; cl17710
106370002523	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
106370002524	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
106370002525	DDE superfamily endonuclease; Region: DDE_4; pfam13359
106370002526	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
106370002527	FAD binding domain; Region: FAD_binding_4; pfam01565
106370002528	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
106370002529	sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168
106370002530	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
106370002531	Ligand binding site; other site
106370002532	Putative Catalytic site; other site
106370002533	DXD motif; other site
106370002534	GtrA-like protein; Region: GtrA; pfam04138
106370002535	Predicted membrane protein [Function unknown]; Region: COG2246
106370002536	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
106370002537	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
106370002538	DXD motif; other site
106370002539	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
106370002540	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
106370002541	Zn binding site [ion binding]; other site
106370002542	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
106370002543	iron-sulfur cluster [ion binding]; other site
106370002544	[2Fe-2S] cluster binding site [ion binding]; other site
106370002545	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
106370002546	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
106370002547	phosphopeptide binding site; other site
106370002548	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370002549	S-adenosylmethionine binding site [chemical binding]; other site
106370002550	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
106370002551	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
106370002552	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
106370002553	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
106370002554	NAD(P) binding site [chemical binding]; other site
106370002555	active site
106370002556	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
106370002557	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
106370002558	dimer interface [polypeptide binding]; other site
106370002559	phosphorylation site [posttranslational modification]
106370002560	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
106370002561	ATP binding site [chemical binding]; other site
106370002562	Mg2+ binding site [ion binding]; other site
106370002563	G-X-G motif; other site
106370002564	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
106370002565	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
106370002566	active site
106370002567	phosphorylation site [posttranslational modification]
106370002568	intermolecular recognition site; other site
106370002569	dimerization interface [polypeptide binding]; other site
106370002570	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
106370002571	DNA binding site [nucleotide binding]
106370002572	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
106370002573	active site
106370002574	Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492
106370002575	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
106370002576	Oxidoreductase molybdopterin binding domain; Region: Oxidored_molyb; pfam00174
106370002577	Moco binding site; other site
106370002578	metal coordination site [ion binding]; other site
106370002579	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
106370002580	dimerization interface [polypeptide binding]; other site
106370002581	putative DNA binding site [nucleotide binding]; other site
106370002582	putative Zn2+ binding site [ion binding]; other site
106370002583	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
106370002584	hydrophobic ligand binding site; other site
106370002585	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
106370002586	dimerization interface [polypeptide binding]; other site
106370002587	putative DNA binding site [nucleotide binding]; other site
106370002588	putative Zn2+ binding site [ion binding]; other site
106370002589	Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326
106370002590	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
106370002591	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
106370002592	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
106370002593	ATP-grasp domain; Region: ATP-grasp_4; cl17255
106370002594	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
106370002595	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
106370002596	carboxyltransferase (CT) interaction site; other site
106370002597	biotinylation site [posttranslational modification]; other site
106370002598	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
106370002599	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
106370002600	dimer interface [polypeptide binding]; other site
106370002601	active site
106370002602	CoA binding pocket [chemical binding]; other site
106370002603	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
106370002604	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
106370002605	active site
106370002606	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
106370002607	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
106370002608	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
106370002609	Predicted ATPase [General function prediction only]; Region: COG3903
106370002610	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
106370002611	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
106370002612	DNA binding residues [nucleotide binding]
106370002613	dimerization interface [polypeptide binding]; other site
106370002614	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
106370002615	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
106370002616	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
106370002617	Lipocalin-like domain; Region: Lipocalin_5; pfam13924
106370002618	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
106370002619	crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751
106370002620	NAD(P) binding site [chemical binding]; other site
106370002621	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
106370002622	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
106370002623	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
106370002624	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
106370002625	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
106370002626	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
106370002627	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
106370002628	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
106370002629	putative nucleic acid binding site [nucleotide binding]; other site
106370002630	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
106370002631	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
106370002632	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
106370002633	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370002634	S-adenosylmethionine binding site [chemical binding]; other site
106370002635	PAS domain S-box; Region: sensory_box; TIGR00229
106370002636	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
106370002637	putative active site [active]
106370002638	heme pocket [chemical binding]; other site
106370002639	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
106370002640	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
106370002641	metal binding site [ion binding]; metal-binding site
106370002642	active site
106370002643	I-site; other site
106370002644	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
106370002645	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
106370002646	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
106370002647	gas vesicle synthesis-like protein; Reviewed; Region: PRK09368
106370002648	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
106370002649	MOSC domain; Region: MOSC; pfam03473
106370002650	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
106370002651	Low molecular weight phosphatase family; Region: LMWPc; cl00105
106370002652	active site
106370002653	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
106370002654	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
106370002655	active site
106370002656	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
106370002657	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
106370002658	putative active site [active]
106370002659	putative metal binding site [ion binding]; other site
106370002660	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
106370002661	Uncharacterized conserved protein [Function unknown]; Region: COG1262
106370002662	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
106370002663	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
106370002664	RNA binding site [nucleotide binding]; other site
106370002665	Transposase; Region: DEDD_Tnp_IS110; pfam01548
106370002666	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
106370002667	Winged helix-turn helix; Region: HTH_29; pfam13551
106370002668	Helix-turn-helix domain; Region: HTH_28; pfam13518
106370002669	Homeodomain-like domain; Region: HTH_32; pfam13565
106370002670	DDE superfamily endonuclease; Region: DDE_3; pfam13358
106370002671	Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299
106370002672	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
106370002673	active site
106370002674	substrate binding site [chemical binding]; other site
106370002675	cosubstrate binding site; other site
106370002676	catalytic site [active]
106370002677	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
106370002678	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370002679	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
106370002680	non-specific DNA binding site [nucleotide binding]; other site
106370002681	salt bridge; other site
106370002682	sequence-specific DNA binding site [nucleotide binding]; other site
106370002683	Frankia-40 domain; Region: Frankia_40_dom; TIGR03917
106370002684	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370002685	non-specific DNA binding site [nucleotide binding]; other site
106370002686	salt bridge; other site
106370002687	sequence-specific DNA binding site [nucleotide binding]; other site
106370002688	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
106370002689	Helix-turn-helix domain; Region: HTH_17; pfam12728
106370002690	Frankia-40 domain; Region: Frankia_40_dom; TIGR03917
106370002691	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
106370002692	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
106370002693	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
106370002694	Walker A/P-loop; other site
106370002695	ATP binding site [chemical binding]; other site
106370002696	Q-loop/lid; other site
106370002697	ABC transporter signature motif; other site
106370002698	Walker B; other site
106370002699	D-loop; other site
106370002700	H-loop/switch region; other site
106370002701	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
106370002702	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
106370002703	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
106370002704	Walker A/P-loop; other site
106370002705	ATP binding site [chemical binding]; other site
106370002706	Q-loop/lid; other site
106370002707	ABC transporter signature motif; other site
106370002708	Walker B; other site
106370002709	D-loop; other site
106370002710	H-loop/switch region; other site
106370002711	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
106370002712	active site
106370002713	catalytic triad [active]
106370002714	oxyanion hole [active]
106370002715	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959
106370002716	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
106370002717	NodB motif; other site
106370002718	putative active site [active]
106370002719	putative catalytic site [active]
106370002720	putative Zn binding site [ion binding]; other site
106370002721	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
106370002722	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
106370002723	NAD(P) binding site [chemical binding]; other site
106370002724	catalytic residues [active]
106370002725	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
106370002726	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
106370002727	active site
106370002728	phosphorylation site [posttranslational modification]
106370002729	intermolecular recognition site; other site
106370002730	dimerization interface [polypeptide binding]; other site
106370002731	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
106370002732	DNA binding residues [nucleotide binding]
106370002733	dimerization interface [polypeptide binding]; other site
106370002734	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
106370002735	catalytic site [active]
106370002736	putative active site [active]
106370002737	putative substrate binding site [chemical binding]; other site
106370002738	dimer interface [polypeptide binding]; other site
106370002739	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
106370002740	Uncharacterized conserved protein [Function unknown]; Region: COG4278
106370002741	ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004
106370002742	ATP binding site [chemical binding]; other site
106370002743	Walker A motif; other site
106370002744	Walker B motif; other site
106370002745	Pirin-related protein [General function prediction only]; Region: COG1741
106370002746	Pirin; Region: Pirin; pfam02678
106370002747	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
106370002748	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
106370002749	Domain of unknown function (DUF3367); Region: DUF3367; pfam11847
106370002750	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
106370002751	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
106370002752	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
106370002753	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
106370002754	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
106370002755	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
106370002756	NADP-binding site; other site
106370002757	homotetramer interface [polypeptide binding]; other site
106370002758	substrate binding site [chemical binding]; other site
106370002759	homodimer interface [polypeptide binding]; other site
106370002760	active site
106370002761	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
106370002762	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
106370002763	active site
106370002764	catalytic triad [active]
106370002765	oxyanion hole [active]
106370002766	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
106370002767	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
106370002768	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
106370002769	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
106370002770	RNA binding site [nucleotide binding]; other site
106370002771	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
106370002772	RNA binding site [nucleotide binding]; other site
106370002773	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
106370002774	RNA binding site [nucleotide binding]; other site
106370002775	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
106370002776	RNA binding site [nucleotide binding]; other site
106370002777	Trm112p-like protein; Region: Trm112p; cl01066
106370002778	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
106370002779	catalytic residues [active]
106370002780	dimer interface [polypeptide binding]; other site
106370002781	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_11; cd13126
106370002782	Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755
106370002783	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
106370002784	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
106370002785	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
106370002786	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
106370002787	dimerization interface [polypeptide binding]; other site
106370002788	ATP binding site [chemical binding]; other site
106370002789	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
106370002790	HupF/HypC family; Region: HupF_HypC; pfam01455
106370002791	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
106370002792	Acylphosphatase; Region: Acylphosphatase; cl00551
106370002793	HypF finger; Region: zf-HYPF; pfam07503
106370002794	HypF finger; Region: zf-HYPF; pfam07503
106370002795	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
106370002796	Tetratricopeptide repeat; Region: TPR_12; pfam13424
106370002797	This group of endopeptidases include HupW enzymes that are specific to the cyanobacterial hydrogenase and are involved in the C-terminal cleavage of the hydrogenase large subunit precursor protein. Cyanobacterial nickel-iron (NiFe)-hydrogenases are found...; Region: H2MP_Cyano-H2up; cd06063
106370002798	nickel binding site [ion binding]; other site
106370002799	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
106370002800	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
106370002801	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
106370002802	hydrogenase nickel insertion protein HypA; Region: hypA; TIGR00100
106370002803	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
106370002804	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
106370002805	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
106370002806	TIGR02679 family protein; Region: TIGR02679
106370002807	Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664
106370002808	TIGR02680 family protein; Region: TIGR02680
106370002809	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
106370002810	Protein of unknown function (DUF2398); Region: DUF2398; pfam09661
106370002811	Protein of unknown function (DUF2397); Region: DUF2397; pfam09660
106370002812	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
106370002813	FAD binding domain; Region: FAD_binding_4; pfam01565
106370002814	Berberine and berberine like; Region: BBE; pfam08031
106370002815	DEAD-like helicases superfamily; Region: DEXDc; smart00487
106370002816	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
106370002817	ATP binding site [chemical binding]; other site
106370002818	putative Mg++ binding site [ion binding]; other site
106370002819	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
106370002820	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
106370002821	nucleotide binding region [chemical binding]; other site
106370002822	ATP-binding site [chemical binding]; other site
106370002823	DDE superfamily endonuclease; Region: DDE_5; cl17874
106370002824	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
106370002825	Fic/DOC family; Region: Fic; cl00960
106370002826	Protein of unknown function (DUF433); Region: DUF433; pfam04255
106370002827	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
106370002828	active site
106370002829	Int/Topo IB signature motif; other site
106370002830	DNA binding site [nucleotide binding]
106370002831	Beta-lactamase; Region: Beta-lactamase; cl17358
106370002832	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
106370002833	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
106370002834	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
106370002835	nudix motif; other site
106370002836	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
106370002837	Predicted helicase [General function prediction only]; Region: COG4889
106370002838	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
106370002839	DDE superfamily endonuclease; Region: DDE_5; cl17874
106370002840	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
106370002841	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
106370002842	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
106370002843	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
106370002844	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
106370002845	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
106370002846	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
106370002847	conserved hypothetical protein; Region: TIGR03843
106370002848	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
106370002849	Cytochrome P450; Region: p450; cl12078
106370002850	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
106370002851	tetramerization interface [polypeptide binding]; other site
106370002852	active site
106370002853	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370002854	S-adenosylmethionine binding site [chemical binding]; other site
106370002855	Acyl transferase domain; Region: Acyl_transf_1; cl08282
106370002856	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
106370002857	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
106370002858	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
106370002859	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
106370002860	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
106370002861	putative substrate translocation pore; other site
106370002862	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
106370002863	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
106370002864	Protein of unknown function (DUF3037); Region: DUF3037; pfam11236
106370002865	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
106370002866	DDE superfamily endonuclease; Region: DDE_4; pfam13359
106370002867	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
106370002868	active site
106370002869	ATP binding site [chemical binding]; other site
106370002870	substrate binding site [chemical binding]; other site
106370002871	thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891
106370002872	Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147
106370002873	LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793
106370002874	active site
106370002875	zinc binding site [ion binding]; other site
106370002876	Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737
106370002877	Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738
106370002878	thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891
106370002879	methyltransferase, FxLD system; Region: methyltran_FxLD; TIGR04364
106370002880	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370002881	S-adenosylmethionine binding site [chemical binding]; other site
106370002882	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
106370002883	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
106370002884	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
106370002885	Mrr N-terminal domain; Region: Mrr_N; pfam14338
106370002886	Restriction endonuclease; Region: Mrr_cat; pfam04471
106370002887	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
106370002888	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676
106370002889	nudix motif; other site
106370002890	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
106370002891	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370002892	non-specific DNA binding site [nucleotide binding]; other site
106370002893	salt bridge; other site
106370002894	sequence-specific DNA binding site [nucleotide binding]; other site
106370002895	Frankia-40 domain; Region: Frankia_40_dom; TIGR03917
106370002896	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370002897	non-specific DNA binding site [nucleotide binding]; other site
106370002898	salt bridge; other site
106370002899	sequence-specific DNA binding site [nucleotide binding]; other site
106370002900	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
106370002901	Frankia-40 domain; Region: Frankia_40_dom; TIGR03917
106370002902	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
106370002903	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
106370002904	Int/Topo IB signature motif; other site
106370002905	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
106370002906	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
106370002907	dimer interface [polypeptide binding]; other site
106370002908	ssDNA binding site [nucleotide binding]; other site
106370002909	tetramer (dimer of dimers) interface [polypeptide binding]; other site
106370002910	Uncharacterized conserved protein [Function unknown]; Region: COG5361
106370002911	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
106370002912	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
106370002913	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
106370002914	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
106370002915	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
106370002916	ABC transporter; Region: ABC_tran_2; pfam12848
106370002917	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
106370002918	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
106370002919	apolar tunnel; other site
106370002920	heme binding site [chemical binding]; other site
106370002921	dimerization interface [polypeptide binding]; other site
106370002922	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
106370002923	active site
106370002924	catalytic site [active]
106370002925	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
106370002926	GAF domain; Region: GAF_3; pfam13492
106370002927	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
106370002928	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
106370002929	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
106370002930	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
106370002931	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
106370002932	atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245
106370002933	putative NAD(P) binding site [chemical binding]; other site
106370002934	putative active site [active]
106370002935	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
106370002936	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
106370002937	active site
106370002938	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
106370002939	Mechanosensitive ion channel; Region: MS_channel; pfam00924
106370002940	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
106370002941	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
106370002942	active site
106370002943	phosphorylation site [posttranslational modification]
106370002944	intermolecular recognition site; other site
106370002945	dimerization interface [polypeptide binding]; other site
106370002946	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
106370002947	DNA binding site [nucleotide binding]
106370002948	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
106370002949	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
106370002950	dimerization interface [polypeptide binding]; other site
106370002951	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
106370002952	dimer interface [polypeptide binding]; other site
106370002953	phosphorylation site [posttranslational modification]
106370002954	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
106370002955	ATP binding site [chemical binding]; other site
106370002956	Mg2+ binding site [ion binding]; other site
106370002957	G-X-G motif; other site
106370002958	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
106370002959	Repair protein; Region: Repair_PSII; pfam04536
106370002960	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
106370002961	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
106370002962	Zn binding site [ion binding]; other site
106370002963	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
106370002964	Domain of unknown function DUF20; Region: UPF0118; pfam01594
106370002965	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
106370002966	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
106370002967	active site
106370002968	Domain of unknown function (DUF3367); Region: DUF3367; pfam11847
106370002969	RyR domain; Region: RyR; pfam02026
106370002970	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
106370002971	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
106370002972	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
106370002973	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
106370002974	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
106370002975	Protein of unknown function (DUF1778); Region: DUF1778; cl01845
106370002976	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
106370002977	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
106370002978	active site
106370002979	catalytic tetrad [active]
106370002980	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
106370002981	Acyltransferase family; Region: Acyl_transf_3; pfam01757
106370002982	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
106370002983	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
106370002984	Walker A/P-loop; other site
106370002985	ATP binding site [chemical binding]; other site
106370002986	Q-loop/lid; other site
106370002987	ABC transporter signature motif; other site
106370002988	Walker B; other site
106370002989	D-loop; other site
106370002990	H-loop/switch region; other site
106370002991	CHASE3 domain; Region: CHASE3; pfam05227
106370002992	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
106370002993	dimerization interface [polypeptide binding]; other site
106370002994	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
106370002995	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
106370002996	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
106370002997	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
106370002998	AMP-binding enzyme; Region: AMP-binding; pfam00501
106370002999	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
106370003000	acyl-activating enzyme (AAE) consensus motif; other site
106370003001	AMP binding site [chemical binding]; other site
106370003002	active site
106370003003	CoA binding site [chemical binding]; other site
106370003004	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
106370003005	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
106370003006	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
106370003007	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
106370003008	putative dimer interface [polypeptide binding]; other site
106370003009	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
106370003010	putative catalytic site [active]
106370003011	putative metal binding site [ion binding]; other site
106370003012	putative phosphate binding site [ion binding]; other site
106370003013	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
106370003014	RibD C-terminal domain; Region: RibD_C; cl17279
106370003015	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
106370003016	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
106370003017	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
106370003018	phosphopeptide binding site; other site
106370003019	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
106370003020	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
106370003021	phosphopeptide binding site; other site
106370003022	The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955
106370003023	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
106370003024	Walker A/P-loop; other site
106370003025	ATP binding site [chemical binding]; other site
106370003026	Q-loop/lid; other site
106370003027	ABC transporter signature motif; other site
106370003028	Walker B; other site
106370003029	D-loop; other site
106370003030	H-loop/switch region; other site
106370003031	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
106370003032	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
106370003033	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
106370003034	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
106370003035	phosphate binding site [ion binding]; other site
106370003036	Domain of unknown function (DUF3291); Region: DUF3291; pfam11695
106370003037	Methyltransferase domain; Region: Methyltransf_23; pfam13489
106370003038	Methyltransferase domain; Region: Methyltransf_12; pfam08242
106370003039	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
106370003040	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
106370003041	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
106370003042	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
106370003043	active site
106370003044	Tetratricopeptide repeat; Region: TPR_12; pfam13424
106370003045	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
106370003046	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
106370003047	active site
106370003048	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
106370003049	DNA-binding residues [nucleotide binding]; DNA binding site
106370003050	nucleotide binding site [chemical binding]; other site
106370003051	polymerase nucleotide-binding site; other site
106370003052	primase nucleotide-binding site [nucleotide binding]; other site
106370003053	Helix-turn-helix domain; Region: HTH_17; cl17695
106370003054	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
106370003055	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
106370003056	active site
106370003057	Int/Topo IB signature motif; other site
106370003058	DNA binding site [nucleotide binding]
106370003059	trigger factor; Provisional; Region: tig; PRK01490
106370003060	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
106370003061	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
106370003062	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
106370003063	Clp protease; Region: CLP_protease; pfam00574
106370003064	oligomer interface [polypeptide binding]; other site
106370003065	active site residues [active]
106370003066	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
106370003067	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
106370003068	oligomer interface [polypeptide binding]; other site
106370003069	active site residues [active]
106370003070	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
106370003071	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
106370003072	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
106370003073	Walker A motif; other site
106370003074	ATP binding site [chemical binding]; other site
106370003075	Walker B motif; other site
106370003076	arginine finger; other site
106370003077	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
106370003078	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
106370003079	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
106370003080	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
106370003081	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
106370003082	active site
106370003083	multimer interface [polypeptide binding]; other site
106370003084	rod shape-determining protein MreB; Provisional; Region: PRK13927
106370003085	MreB and similar proteins; Region: MreB_like; cd10225
106370003086	nucleotide binding site [chemical binding]; other site
106370003087	Mg binding site [ion binding]; other site
106370003088	putative protofilament interaction site [polypeptide binding]; other site
106370003089	RodZ interaction site [polypeptide binding]; other site
106370003090	rod shape-determining protein MreC; Provisional; Region: PRK13922
106370003091	rod shape-determining protein MreC; Region: MreC; pfam04085
106370003092	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
106370003093	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
106370003094	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
106370003095	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
106370003096	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
106370003097	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
106370003098	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
106370003099	B12 binding site [chemical binding]; other site
106370003100	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
106370003101	FeS/SAM binding site; other site
106370003102	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
106370003103	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105
106370003104	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
106370003105	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
106370003106	homodimer interface [polypeptide binding]; other site
106370003107	oligonucleotide binding site [chemical binding]; other site
106370003108	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
106370003109	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
106370003110	GTPase CgtA; Reviewed; Region: obgE; PRK12297
106370003111	GTP1/OBG; Region: GTP1_OBG; pfam01018
106370003112	Obg GTPase; Region: Obg; cd01898
106370003113	G1 box; other site
106370003114	GTP/Mg2+ binding site [chemical binding]; other site
106370003115	Switch I region; other site
106370003116	G2 box; other site
106370003117	G3 box; other site
106370003118	Switch II region; other site
106370003119	G4 box; other site
106370003120	G5 box; other site
106370003121	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
106370003122	gamma-glutamyl kinase; Provisional; Region: PRK05429
106370003123	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
106370003124	nucleotide binding site [chemical binding]; other site
106370003125	homotetrameric interface [polypeptide binding]; other site
106370003126	putative phosphate binding site [ion binding]; other site
106370003127	putative allosteric binding site; other site
106370003128	PUA domain; Region: PUA; pfam01472
106370003129	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
106370003130	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
106370003131	Walker A/P-loop; other site
106370003132	ATP binding site [chemical binding]; other site
106370003133	Q-loop/lid; other site
106370003134	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
106370003135	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
106370003136	ABC transporter signature motif; other site
106370003137	Walker B; other site
106370003138	D-loop; other site
106370003139	H-loop/switch region; other site
106370003140	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
106370003141	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
106370003142	active site
106370003143	metal binding site [ion binding]; metal-binding site
106370003144	DNA binding site [nucleotide binding]
106370003145	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
106370003146	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
106370003147	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
106370003148	putative catalytic cysteine [active]
106370003149	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
106370003150	malate synthase A; Region: malate_syn_A; TIGR01344
106370003151	active site
106370003152	MoxR-like ATPases [General function prediction only]; Region: COG0714
106370003153	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
106370003154	Walker A motif; other site
106370003155	ATP binding site [chemical binding]; other site
106370003156	Walker B motif; other site
106370003157	arginine finger; other site
106370003158	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
106370003159	phosphoglucomutase; Validated; Region: PRK07564
106370003160	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
106370003161	active site
106370003162	substrate binding site [chemical binding]; other site
106370003163	metal binding site [ion binding]; metal-binding site
106370003164	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
106370003165	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
106370003166	active site
106370003167	(T/H)XGH motif; other site
106370003168	Oligomerisation domain; Region: Oligomerisation; cl00519
106370003169	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
106370003170	catalytic core [active]
106370003171	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
106370003172	Helix-turn-helix domain; Region: HTH_28; pfam13518
106370003173	Winged helix-turn helix; Region: HTH_29; pfam13551
106370003174	Homeodomain-like domain; Region: HTH_32; pfam13565
106370003175	short chain dehydrogenase; Provisional; Region: PRK07062
106370003176	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
106370003177	putative NAD(P) binding site [chemical binding]; other site
106370003178	putative active site [active]
106370003179	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
106370003180	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
106370003181	Predicted amidohydrolase [General function prediction only]; Region: COG0388
106370003182	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
106370003183	putative active site [active]
106370003184	catalytic triad [active]
106370003185	putative dimer interface [polypeptide binding]; other site
106370003186	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
106370003187	tetracycline repressor protein TetR; Provisional; Region: PRK13756
106370003188	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
106370003189	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
106370003190	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
106370003191	Major Facilitator Superfamily; Region: MFS_1; pfam07690
106370003192	putative substrate translocation pore; other site
106370003193	PAC2 family; Region: PAC2; pfam09754
106370003194	Membrane transport protein; Region: Mem_trans; cl09117
106370003195	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
106370003196	Di-iron ligands [ion binding]; other site
106370003197	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
106370003198	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
106370003199	putative acyl-acceptor binding pocket; other site
106370003200	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
106370003201	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
106370003202	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
106370003203	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
106370003204	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
106370003205	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
106370003206	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
106370003207	Competence protein; Region: Competence; pfam03772
106370003208	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
106370003209	hypothetical protein; Reviewed; Region: PRK07914
106370003210	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
106370003211	GTP-binding protein LepA; Provisional; Region: PRK05433
106370003212	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
106370003213	G1 box; other site
106370003214	putative GEF interaction site [polypeptide binding]; other site
106370003215	GTP/Mg2+ binding site [chemical binding]; other site
106370003216	Switch I region; other site
106370003217	G2 box; other site
106370003218	G3 box; other site
106370003219	Switch II region; other site
106370003220	G4 box; other site
106370003221	G5 box; other site
106370003222	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
106370003223	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
106370003224	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
106370003225	coproporphyrinogen III oxidase; Validated; Region: PRK05628
106370003226	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
106370003227	FeS/SAM binding site; other site
106370003228	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
106370003229	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
106370003230	chaperone protein DnaJ; Provisional; Region: PRK14278
106370003231	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
106370003232	HSP70 interaction site [polypeptide binding]; other site
106370003233	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
106370003234	Zn binding sites [ion binding]; other site
106370003235	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
106370003236	dimer interface [polypeptide binding]; other site
106370003237	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
106370003238	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
106370003239	PhoH-like protein; Region: PhoH; pfam02562
106370003240	metal-binding heat shock protein; Provisional; Region: PRK00016
106370003241	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
106370003242	Domain of unknown function DUF21; Region: DUF21; pfam01595
106370003243	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
106370003244	Transporter associated domain; Region: CorC_HlyC; smart01091
106370003245	GTPase Era; Reviewed; Region: era; PRK00089
106370003246	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
106370003247	G1 box; other site
106370003248	GTP/Mg2+ binding site [chemical binding]; other site
106370003249	Switch I region; other site
106370003250	G2 box; other site
106370003251	Switch II region; other site
106370003252	G3 box; other site
106370003253	G4 box; other site
106370003254	G5 box; other site
106370003255	KH domain; Region: KH_2; pfam07650
106370003256	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
106370003257	Recombination protein O N terminal; Region: RecO_N; pfam11967
106370003258	Recombination protein O C terminal; Region: RecO_C; pfam02565
106370003259	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
106370003260	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
106370003261	catalytic residue [active]
106370003262	putative FPP diphosphate  binding site; other site
106370003263	putative FPP binding hydrophobic cleft; other site
106370003264	dimer interface [polypeptide binding]; other site
106370003265	putative IPP diphosphate binding site; other site
106370003266	glycyl-tRNA synthetase; Provisional; Region: PRK14908
106370003267	glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348
106370003268	motif 1; other site
106370003269	dimer interface [polypeptide binding]; other site
106370003270	active site
106370003271	motif 2; other site
106370003272	motif 3; other site
106370003273	pyruvate phosphate dikinase; Provisional; Region: PRK09279
106370003274	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
106370003275	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
106370003276	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
106370003277	Uncharacterized conserved protein [Function unknown]; Region: COG1434
106370003278	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
106370003279	putative active site [active]
106370003280	transketolase; Reviewed; Region: PRK05899
106370003281	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
106370003282	TPP-binding site [chemical binding]; other site
106370003283	dimer interface [polypeptide binding]; other site
106370003284	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
106370003285	PYR/PP interface [polypeptide binding]; other site
106370003286	dimer interface [polypeptide binding]; other site
106370003287	TPP binding site [chemical binding]; other site
106370003288	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
106370003289	Bacterial PH domain; Region: DUF304; pfam03703
106370003290	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
106370003291	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
106370003292	Zn2+ binding site [ion binding]; other site
106370003293	Mg2+ binding site [ion binding]; other site
106370003294	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
106370003295	DNA primase; Validated; Region: dnaG; PRK05667
106370003296	CHC2 zinc finger; Region: zf-CHC2; cl17510
106370003297	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
106370003298	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
106370003299	active site
106370003300	metal binding site [ion binding]; metal-binding site
106370003301	interdomain interaction site; other site
106370003302	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
106370003303	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
106370003304	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
106370003305	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
106370003306	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
106370003307	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
106370003308	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
106370003309	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
106370003310	DNA binding residues [nucleotide binding]
106370003311	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
106370003312	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
106370003313	Methyltransferase domain; Region: Methyltransf_23; pfam13489
106370003314	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370003315	S-adenosylmethionine binding site [chemical binding]; other site
106370003316	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
106370003317	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
106370003318	metal binding site [ion binding]; metal-binding site
106370003319	active site
106370003320	I-site; other site
106370003321	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
106370003322	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
106370003323	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
106370003324	Low molecular weight phosphatase family; Region: LMWPc; cl00105
106370003325	active site
106370003326	Macrocin-O-methyltransferase (TylF); Region: TylF; pfam05711
106370003327	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
106370003328	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
106370003329	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
106370003330	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
106370003331	NAD binding site [chemical binding]; other site
106370003332	putative substrate binding site 2 [chemical binding]; other site
106370003333	putative substrate binding site 1 [chemical binding]; other site
106370003334	active site
106370003335	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
106370003336	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
106370003337	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
106370003338	active site
106370003339	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
106370003340	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
106370003341	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
106370003342	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
106370003343	putative metal binding site; other site
106370003344	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
106370003345	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
106370003346	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
106370003347	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
106370003348	NAD(P) binding site [chemical binding]; other site
106370003349	active site
106370003350	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
106370003351	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
106370003352	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
106370003353	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
106370003354	Mg++ binding site [ion binding]; other site
106370003355	putative catalytic motif [active]
106370003356	putative substrate binding site [chemical binding]; other site
106370003357	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
106370003358	putative NAD(P) binding site [chemical binding]; other site
106370003359	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
106370003360	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
106370003361	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
106370003362	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
106370003363	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
106370003364	NADP-binding site; other site
106370003365	homotetramer interface [polypeptide binding]; other site
106370003366	substrate binding site [chemical binding]; other site
106370003367	homodimer interface [polypeptide binding]; other site
106370003368	active site
106370003369	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
106370003370	active site
106370003371	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
106370003372	homodimer interface [polypeptide binding]; other site
106370003373	UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721
106370003374	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
106370003375	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
106370003376	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
106370003377	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
106370003378	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
106370003379	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
106370003380	aconitate hydratase; Validated; Region: PRK09277
106370003381	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
106370003382	substrate binding site [chemical binding]; other site
106370003383	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
106370003384	ligand binding site [chemical binding]; other site
106370003385	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
106370003386	substrate binding site [chemical binding]; other site
106370003387	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
106370003388	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
106370003389	active site
106370003390	valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208
106370003391	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
106370003392	active site
106370003393	HIGH motif; other site
106370003394	nucleotide binding site [chemical binding]; other site
106370003395	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
106370003396	active site
106370003397	KMSKS motif; other site
106370003398	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
106370003399	tRNA binding surface [nucleotide binding]; other site
106370003400	anticodon binding site; other site
106370003401	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
106370003402	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
106370003403	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
106370003404	trimer interface [polypeptide binding]; other site
106370003405	putative metal binding site [ion binding]; other site
106370003406	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
106370003407	trimer interface [polypeptide binding]; other site
106370003408	active site
106370003409	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
106370003410	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
106370003411	generic binding surface II; other site
106370003412	ssDNA binding site; other site
106370003413	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
106370003414	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
106370003415	TrkA-N domain; Region: TrkA_N; pfam02254
106370003416	TrkA-C domain; Region: TrkA_C; pfam02080
106370003417	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
106370003418	TrkA-N domain; Region: TrkA_N; pfam02254
106370003419	TrkA-C domain; Region: TrkA_C; pfam02080
106370003420	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
106370003421	TRAM domain; Region: TRAM; pfam01938
106370003422	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
106370003423	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
106370003424	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
106370003425	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
106370003426	TPP-binding site; other site
106370003427	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
106370003428	PYR/PP interface [polypeptide binding]; other site
106370003429	dimer interface [polypeptide binding]; other site
106370003430	TPP binding site [chemical binding]; other site
106370003431	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
106370003432	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
106370003433	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
106370003434	substrate binding site [chemical binding]; other site
106370003435	oxyanion hole (OAH) forming residues; other site
106370003436	trimer interface [polypeptide binding]; other site
106370003437	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
106370003438	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
106370003439	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
106370003440	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
106370003441	dimer interface [polypeptide binding]; other site
106370003442	active site
106370003443	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
106370003444	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
106370003445	catalytic site [active]
106370003446	putative active site [active]
106370003447	putative substrate binding site [chemical binding]; other site
106370003448	HRDC domain; Region: HRDC; pfam00570
106370003449	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
106370003450	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
106370003451	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
106370003452	substrate binding site [chemical binding]; other site
106370003453	active site
106370003454	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
106370003455	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
106370003456	Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253
106370003457	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
106370003458	Bacterial sugar transferase; Region: Bac_transf; pfam02397
106370003459	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
106370003460	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
106370003461	ligand-binding site [chemical binding]; other site
106370003462	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
106370003463	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
106370003464	active site
106370003465	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
106370003466	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
106370003467	Active Sites [active]
106370003468	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
106370003469	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
106370003470	CysD dimerization site [polypeptide binding]; other site
106370003471	G1 box; other site
106370003472	putative GEF interaction site [polypeptide binding]; other site
106370003473	GTP/Mg2+ binding site [chemical binding]; other site
106370003474	Switch I region; other site
106370003475	G2 box; other site
106370003476	G3 box; other site
106370003477	Switch II region; other site
106370003478	G4 box; other site
106370003479	G5 box; other site
106370003480	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
106370003481	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
106370003482	hypothetical protein; Provisional; Region: PRK14059
106370003483	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
106370003484	AFG1-like ATPase; Region: AFG1_ATPase; pfam03969
106370003485	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
106370003486	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
106370003487	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
106370003488	catalytic site [active]
106370003489	active site
106370003490	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
106370003491	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
106370003492	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
106370003493	active site
106370003494	catalytic site [active]
106370003495	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
106370003496	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
106370003497	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
106370003498	active site
106370003499	catalytic site [active]
106370003500	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
106370003501	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
106370003502	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
106370003503	Protein of unknown function (DUF3145); Region: DUF3145; pfam11343
106370003504	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
106370003505	Isochorismatase family; Region: Isochorismatase; pfam00857
106370003506	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
106370003507	catalytic triad [active]
106370003508	conserved cis-peptide bond; other site
106370003509	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
106370003510	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
106370003511	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
106370003512	active site
106370003513	metal binding site [ion binding]; metal-binding site
106370003514	aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824
106370003515	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
106370003516	Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686
106370003517	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
106370003518	nucleotide binding site/active site [active]
106370003519	HIT family signature motif; other site
106370003520	catalytic residue [active]
106370003521	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
106370003522	elongation factor G; Reviewed; Region: PRK12740
106370003523	G1 box; other site
106370003524	GTP/Mg2+ binding site [chemical binding]; other site
106370003525	G2 box; other site
106370003526	Switch I region; other site
106370003527	G3 box; other site
106370003528	Switch II region; other site
106370003529	G4 box; other site
106370003530	G5 box; other site
106370003531	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
106370003532	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
106370003533	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
106370003534	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
106370003535	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
106370003536	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
106370003537	putative acyl-acceptor binding pocket; other site
106370003538	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
106370003539	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
106370003540	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
106370003541	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
106370003542	active site
106370003543	multimer interface [polypeptide binding]; other site
106370003544	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
106370003545	predicted active site [active]
106370003546	catalytic triad [active]
106370003547	hypothetical protein; Validated; Region: PRK00110
106370003548	Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039
106370003549	active site
106370003550	putative DNA-binding cleft [nucleotide binding]; other site
106370003551	dimer interface [polypeptide binding]; other site
106370003552	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
106370003553	RuvA N terminal domain; Region: RuvA_N; pfam01330
106370003554	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
106370003555	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
106370003556	Walker A motif; other site
106370003557	ATP binding site [chemical binding]; other site
106370003558	Walker B motif; other site
106370003559	arginine finger; other site
106370003560	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
106370003561	Preprotein translocase subunit; Region: YajC; pfam02699
106370003562	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
106370003563	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
106370003564	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
106370003565	Protein export membrane protein; Region: SecD_SecF; pfam02355
106370003566	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
106370003567	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
106370003568	HD domain; Region: HD_4; pfam13328
106370003569	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
106370003570	synthetase active site [active]
106370003571	NTP binding site [chemical binding]; other site
106370003572	metal binding site [ion binding]; metal-binding site
106370003573	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
106370003574	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
106370003575	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
106370003576	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
106370003577	Zn2+ binding site [ion binding]; other site
106370003578	Mg2+ binding site [ion binding]; other site
106370003579	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
106370003580	synthetase active site [active]
106370003581	NTP binding site [chemical binding]; other site
106370003582	metal binding site [ion binding]; metal-binding site
106370003583	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
106370003584	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
106370003585	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
106370003586	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
106370003587	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370003588	salt bridge; other site
106370003589	non-specific DNA binding site [nucleotide binding]; other site
106370003590	sequence-specific DNA binding site [nucleotide binding]; other site
106370003591	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
106370003592	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
106370003593	ATP binding site [chemical binding]; other site
106370003594	putative Mg++ binding site [ion binding]; other site
106370003595	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
106370003596	active site
106370003597	seryl-tRNA synthetase; Provisional; Region: PRK05431
106370003598	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
106370003599	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
106370003600	dimer interface [polypeptide binding]; other site
106370003601	active site
106370003602	motif 1; other site
106370003603	motif 2; other site
106370003604	motif 3; other site
106370003605	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
106370003606	active site lid residues [active]
106370003607	catalytic residues [active]
106370003608	substrate binding pocket [chemical binding]; other site
106370003609	substrate-Mg2+ binding site; other site
106370003610	aspartate-rich region 1; other site
106370003611	aspartate-rich region 2; other site
106370003612	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
106370003613	metal ion-dependent adhesion site (MIDAS); other site
106370003614	Protein of unknown function DUF58; Region: DUF58; pfam01882
106370003615	MoxR-like ATPases [General function prediction only]; Region: COG0714
106370003616	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
106370003617	Walker A motif; other site
106370003618	ATP binding site [chemical binding]; other site
106370003619	Walker B motif; other site
106370003620	arginine finger; other site
106370003621	phytoene desaturase; Region: crtI_fam; TIGR02734
106370003622	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
106370003623	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
106370003624	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
106370003625	substrate binding pocket [chemical binding]; other site
106370003626	chain length determination region; other site
106370003627	substrate-Mg2+ binding site; other site
106370003628	catalytic residues [active]
106370003629	aspartate-rich region 1; other site
106370003630	active site lid residues [active]
106370003631	aspartate-rich region 2; other site
106370003632	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
106370003633	FAD binding site [chemical binding]; other site
106370003634	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
106370003635	phytoene desaturase; Region: crtI_fam; TIGR02734
106370003636	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
106370003637	active site
106370003638	carotene biosynthesis associated membrane protein; Region: crt_membr_arch; TIGR03460
106370003639	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
106370003640	Coenzyme A binding pocket [chemical binding]; other site
106370003641	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
106370003642	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
106370003643	NAD binding site [chemical binding]; other site
106370003644	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
106370003645	DNA binding site [nucleotide binding]
106370003646	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
106370003647	NB-ARC domain; Region: NB-ARC; pfam00931
106370003648	Tetratricopeptide repeat; Region: TPR_12; pfam13424
106370003649	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
106370003650	binding surface
106370003651	TPR motif; other site
106370003652	Tetratricopeptide repeat; Region: TPR_12; pfam13424
106370003653	Methyltransferase domain; Region: Methyltransf_31; pfam13847
106370003654	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370003655	S-adenosylmethionine binding site [chemical binding]; other site
106370003656	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
106370003657	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
106370003658	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
106370003659	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
106370003660	Protein of unknown function DUF58; Region: DUF58; pfam01882
106370003661	MoxR-like ATPases [General function prediction only]; Region: COG0714
106370003662	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
106370003663	Walker A motif; other site
106370003664	ATP binding site [chemical binding]; other site
106370003665	Walker B motif; other site
106370003666	arginine finger; other site
106370003667	cell division protein MraZ; Reviewed; Region: PRK00326
106370003668	MraZ protein; Region: MraZ; pfam02381
106370003669	MraZ protein; Region: MraZ; pfam02381
106370003670	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
106370003671	MraW methylase family; Region: Methyltransf_5; cl17771
106370003672	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
106370003673	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
106370003674	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
106370003675	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
106370003676	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
106370003677	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
106370003678	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
106370003679	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
106370003680	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
106370003681	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
106370003682	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
106370003683	Mg++ binding site [ion binding]; other site
106370003684	putative catalytic motif [active]
106370003685	putative substrate binding site [chemical binding]; other site
106370003686	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438
106370003687	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
106370003688	cell division protein FtsW; Region: ftsW; TIGR02614
106370003689	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
106370003690	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
106370003691	active site
106370003692	homodimer interface [polypeptide binding]; other site
106370003693	Domain of unknown function (DUF385); Region: DUF385; pfam04075
106370003694	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
106370003695	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
106370003696	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
106370003697	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
106370003698	cell division protein FtsZ; Validated; Region: PRK09330
106370003699	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
106370003700	nucleotide binding site [chemical binding]; other site
106370003701	SulA interaction site; other site
106370003702	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
106370003703	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
106370003704	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
106370003705	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
106370003706	catalytic residue [active]
106370003707	Protein of unknown function (DUF552); Region: DUF552; cl00775
106370003708	DivIVA protein; Region: DivIVA; pfam05103
106370003709	DivIVA domain; Region: DivI1A_domain; TIGR03544
106370003710	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
106370003711	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
106370003712	HIGH motif; other site
106370003713	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
106370003714	active site
106370003715	KMSKS motif; other site
106370003716	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
106370003717	tRNA binding surface [nucleotide binding]; other site
106370003718	anticodon binding site; other site
106370003719	lipoprotein signal peptidase; Provisional; Region: PRK14764
106370003720	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
106370003721	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
106370003722	active site
106370003723	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
106370003724	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
106370003725	Walker A/P-loop; other site
106370003726	ATP binding site [chemical binding]; other site
106370003727	Q-loop/lid; other site
106370003728	ABC transporter signature motif; other site
106370003729	Walker B; other site
106370003730	D-loop; other site
106370003731	H-loop/switch region; other site
106370003732	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
106370003733	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
106370003734	active site
106370003735	Uncharacterized conserved protein [Function unknown]; Region: COG0327
106370003736	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
106370003737	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
106370003738	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
106370003739	Putative zinc ribbon domain; Region: DUF164; pfam02591
106370003740	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
106370003741	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
106370003742	RNA/DNA hybrid binding site [nucleotide binding]; other site
106370003743	active site
106370003744	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
106370003745	catalytic core [active]
106370003746	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
106370003747	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
106370003748	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
106370003749	CoenzymeA binding site [chemical binding]; other site
106370003750	subunit interaction site [polypeptide binding]; other site
106370003751	PHB binding site; other site
106370003752	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
106370003753	Catalytic domain of Protein Kinases; Region: PKc; cd00180
106370003754	active site
106370003755	ATP binding site [chemical binding]; other site
106370003756	substrate binding site [chemical binding]; other site
106370003757	activation loop (A-loop); other site
106370003758	Predicted membrane protein [Function unknown]; Region: COG2261
106370003759	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
106370003760	S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451
106370003761	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
106370003762	NAD binding site [chemical binding]; other site
106370003763	catalytic Zn binding site [ion binding]; other site
106370003764	substrate binding site [chemical binding]; other site
106370003765	structural Zn binding site [ion binding]; other site
106370003766	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
106370003767	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
106370003768	P-loop; other site
106370003769	Magnesium ion binding site [ion binding]; other site
106370003770	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
106370003771	Magnesium ion binding site [ion binding]; other site
106370003772	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
106370003773	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
106370003774	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
106370003775	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
106370003776	RNA binding surface [nucleotide binding]; other site
106370003777	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
106370003778	active site
106370003779	prephenate dehydrogenase; Validated; Region: PRK06545
106370003780	prephenate dehydrogenase; Validated; Region: PRK08507
106370003781	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
106370003782	cytidylate kinase; Provisional; Region: cmk; PRK00023
106370003783	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
106370003784	CMP-binding site; other site
106370003785	The sites determining sugar specificity; other site
106370003786	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
106370003787	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
106370003788	putative acyl-acceptor binding pocket; other site
106370003789	GTP-binding protein Der; Reviewed; Region: PRK03003
106370003790	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
106370003791	G1 box; other site
106370003792	GTP/Mg2+ binding site [chemical binding]; other site
106370003793	Switch I region; other site
106370003794	G2 box; other site
106370003795	Switch II region; other site
106370003796	G3 box; other site
106370003797	G4 box; other site
106370003798	G5 box; other site
106370003799	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
106370003800	G1 box; other site
106370003801	GTP/Mg2+ binding site [chemical binding]; other site
106370003802	Switch I region; other site
106370003803	G2 box; other site
106370003804	G3 box; other site
106370003805	Switch II region; other site
106370003806	G4 box; other site
106370003807	G5 box; other site
106370003808	Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829
106370003809	active site
106370003810	putative catalytic site [active]
106370003811	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
106370003812	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
106370003813	NlpC/P60 family; Region: NLPC_P60; pfam00877
106370003814	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
106370003815	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
106370003816	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
106370003817	active site
106370003818	Substrate binding site; other site
106370003819	Mg++ binding site; other site
106370003820	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
106370003821	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
106370003822	GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity.  The protein contains an...; Region: MPG1_transferase; cd05805
106370003823	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
106370003824	Protein of unknown function (DUF1290); Region: DUF1290; pfam06947
106370003825	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
106370003826	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
106370003827	lipoyl attachment site [posttranslational modification]; other site
106370003828	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
106370003829	Double zinc ribbon; Region: DZR; pfam12773
106370003830	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
106370003831	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
106370003832	phosphopeptide binding site; other site
106370003833	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
106370003834	DNA binding residues [nucleotide binding]
106370003835	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
106370003836	Bifunctional nuclease; Region: DNase-RNase; pfam02577
106370003837	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
106370003838	DNA binding residues [nucleotide binding]
106370003839	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
106370003840	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
106370003841	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
106370003842	Walker A/P-loop; other site
106370003843	ATP binding site [chemical binding]; other site
106370003844	Q-loop/lid; other site
106370003845	ABC transporter signature motif; other site
106370003846	Walker B; other site
106370003847	D-loop; other site
106370003848	H-loop/switch region; other site
106370003849	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
106370003850	ABC-2 type transporter; Region: ABC2_membrane; cl17235
106370003851	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
106370003852	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
106370003853	active site
106370003854	homotetramer interface [polypeptide binding]; other site
106370003855	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
106370003856	catalytic core [active]
106370003857	Transcription factor WhiB; Region: Whib; pfam02467
106370003858	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
106370003859	active site residue [active]
106370003860	Cysteine dioxygenase type I; Region: CDO_I; pfam05995
106370003861	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
106370003862	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
106370003863	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
106370003864	Histidine kinase; Region: HisKA_3; pfam07730
106370003865	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
106370003866	ATP binding site [chemical binding]; other site
106370003867	Mg2+ binding site [ion binding]; other site
106370003868	G-X-G motif; other site
106370003869	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
106370003870	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
106370003871	active site
106370003872	phosphorylation site [posttranslational modification]
106370003873	intermolecular recognition site; other site
106370003874	dimerization interface [polypeptide binding]; other site
106370003875	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
106370003876	DNA binding residues [nucleotide binding]
106370003877	dimerization interface [polypeptide binding]; other site
106370003878	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
106370003879	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
106370003880	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
106370003881	inhibitor-cofactor binding pocket; inhibition site
106370003882	pyridoxal 5'-phosphate binding site [chemical binding]; other site
106370003883	catalytic residue [active]
106370003884	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
106370003885	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
106370003886	metal binding site [ion binding]; metal-binding site
106370003887	active site
106370003888	I-site; other site
106370003889	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
106370003890	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
106370003891	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
106370003892	NAD(P) binding pocket [chemical binding]; other site
106370003893	YcfA-like protein; Region: YcfA; pfam07927
106370003894	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
106370003895	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
106370003896	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
106370003897	Protein of unknown function (DUF456); Region: DUF456; pfam04306
106370003898	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
106370003899	Amidinotransferase; Region: Amidinotransf; cl12043
106370003900	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
106370003901	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
106370003902	putative active site [active]
106370003903	homotetrameric interface [polypeptide binding]; other site
106370003904	metal binding site [ion binding]; metal-binding site
106370003905	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
106370003906	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
106370003907	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
106370003908	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
106370003909	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
106370003910	active site
106370003911	metal binding site [ion binding]; metal-binding site
106370003912	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
106370003913	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
106370003914	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
106370003915	putative metal binding site [ion binding]; other site
106370003916	TIR domain; Region: TIR_2; pfam13676
106370003917	TIR domain; Region: TIR_2; pfam13676
106370003918	TIR domain; Region: TIR_2; pfam13676
106370003919	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
106370003920	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
106370003921	P-loop; other site
106370003922	Magnesium ion binding site [ion binding]; other site
106370003923	AAA ATPase domain; Region: AAA_16; pfam13191
106370003924	Tetratricopeptide repeat; Region: TPR_12; pfam13424
106370003925	Tetratricopeptide repeat; Region: TPR_10; pfam13374
106370003926	Tetratricopeptide repeat; Region: TPR_12; pfam13424
106370003927	Tetratricopeptide repeat; Region: TPR_12; pfam13424
106370003928	HEXXH motif domain; Region: mod_HExxH; TIGR04267
106370003929	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
106370003930	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
106370003931	DNA binding residues [nucleotide binding]
106370003932	putative dimer interface [polypeptide binding]; other site
106370003933	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
106370003934	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
106370003935	active site
106370003936	catalytic tetrad [active]
106370003937	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
106370003938	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
106370003939	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
106370003940	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
106370003941	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
106370003942	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
106370003943	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
106370003944	Precorrin-8X methylmutase; Region: CbiC; pfam02570
106370003945	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
106370003946	active site
106370003947	SAM binding site [chemical binding]; other site
106370003948	homodimer interface [polypeptide binding]; other site
106370003949	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
106370003950	homodimer interface [polypeptide binding]; other site
106370003951	active site
106370003952	SAM binding site [chemical binding]; other site
106370003953	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
106370003954	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
106370003955	active site
106370003956	SAM binding site [chemical binding]; other site
106370003957	homodimer interface [polypeptide binding]; other site
106370003958	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
106370003959	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
106370003960	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
106370003961	Walker A motif; other site
106370003962	ATP binding site [chemical binding]; other site
106370003963	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
106370003964	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
106370003965	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
106370003966	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
106370003967	ATP-grasp domain; Region: ATP-grasp_4; cl17255
106370003968	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
106370003969	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
106370003970	carboxyltransferase (CT) interaction site; other site
106370003971	biotinylation site [posttranslational modification]; other site
106370003972	DDE superfamily endonuclease; Region: DDE_5; cl17874
106370003973	Transcriptional regulators [Transcription]; Region: PurR; COG1609
106370003974	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
106370003975	ligand binding site [chemical binding]; other site
106370003976	dimerization interface [polypeptide binding]; other site
106370003977	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
106370003978	active site
106370003979	Mg2+/Mn2+ binding site [ion binding]; other site
106370003980	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
106370003981	RecB family nuclease, putative, TM0106 family; Region: TIGR03491
106370003982	RNase_H superfamily; Region: RNase_H_2; pfam13482
106370003983	Part of AAA domain; Region: AAA_19; pfam13245
106370003984	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
106370003985	AAA domain; Region: AAA_12; pfam13087
106370003986	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
106370003987	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
106370003988	DNA binding residues [nucleotide binding]
106370003989	dimerization interface [polypeptide binding]; other site
106370003990	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
106370003991	ChaB; Region: ChaB; cl01887
106370003992	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
106370003993	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
106370003994	amidase catalytic site [active]
106370003995	Zn binding residues [ion binding]; other site
106370003996	substrate binding site [chemical binding]; other site
106370003997	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
106370003998	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
106370003999	Transcriptional regulators [Transcription]; Region: FadR; COG2186
106370004000	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
106370004001	DNA-binding site [nucleotide binding]; DNA binding site
106370004002	FCD domain; Region: FCD; cl11656
106370004003	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
106370004004	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
106370004005	DNA binding residues [nucleotide binding]
106370004006	dimerization interface [polypeptide binding]; other site
106370004007	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
106370004008	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
106370004009	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
106370004010	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
106370004011	Coenzyme A binding pocket [chemical binding]; other site
106370004012	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
106370004013	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
106370004014	putative NAD(P) binding site [chemical binding]; other site
106370004015	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
106370004016	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
106370004017	active site
106370004018	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
106370004019	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
106370004020	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
106370004021	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
106370004022	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
106370004023	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
106370004024	AAA domain; Region: AAA_30; pfam13604
106370004025	Family description; Region: UvrD_C_2; pfam13538
106370004026	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
106370004027	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
106370004028	putative substrate translocation pore; other site
106370004029	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
106370004030	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
106370004031	DNA binding residues [nucleotide binding]
106370004032	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
106370004033	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
106370004034	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
106370004035	NAD binding site [chemical binding]; other site
106370004036	homodimer interface [polypeptide binding]; other site
106370004037	homotetramer interface [polypeptide binding]; other site
106370004038	active site
106370004039	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
106370004040	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
106370004041	Domain of unknown function (DUF1876); Region: DUF1876; pfam08962
106370004042	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
106370004043	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
106370004044	Histidine kinase; Region: HisKA_3; pfam07730
106370004045	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
106370004046	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
106370004047	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
106370004048	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
106370004049	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
106370004050	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
106370004051	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
106370004052	substrate binding site; other site
106370004053	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
106370004054	extended (e) SDRs; Region: SDR_e; cd08946
106370004055	NAD(P) binding site [chemical binding]; other site
106370004056	active site
106370004057	substrate binding site [chemical binding]; other site
106370004058	Methyltransferase domain; Region: Methyltransf_23; pfam13489
106370004059	Putative methyltransferase; Region: Methyltransf_4; cl17290
106370004060	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370004061	S-adenosylmethionine binding site [chemical binding]; other site
106370004062	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
106370004063	Methyltransferase domain; Region: Methyltransf_23; pfam13489
106370004064	Methyltransferase domain; Region: Methyltransf_11; pfam08241
106370004065	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
106370004066	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
106370004067	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
106370004068	active site
106370004069	Chain length determinant protein; Region: Wzz; cl15801
106370004070	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
106370004071	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
106370004072	Right handed beta helix region; Region: Beta_helix; pfam13229
106370004073	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
106370004074	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
106370004075	active site
106370004076	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
106370004077	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
106370004078	DUF218 domain; Region: DUF218; pfam02698
106370004079	putative active site [active]
106370004080	Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712
106370004081	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
106370004082	Probable Catalytic site; other site
106370004083	metal-binding site
106370004084	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
106370004085	Bacterial sugar transferase; Region: Bac_transf; pfam02397
106370004086	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
106370004087	Ligand binding site; other site
106370004088	Putative Catalytic site; other site
106370004089	DXD motif; other site
106370004090	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
106370004091	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
106370004092	active site
106370004093	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
106370004094	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
106370004095	putative active site [active]
106370004096	putative metal binding site [ion binding]; other site
106370004097	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
106370004098	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
106370004099	active site
106370004100	Methyltransferase domain; Region: Methyltransf_23; pfam13489
106370004101	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
106370004102	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
106370004103	active site
106370004104	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
106370004105	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
106370004106	active site
106370004107	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
106370004108	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
106370004109	putative active site [active]
106370004110	putative metal binding site [ion binding]; other site
106370004111	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
106370004112	RNA binding surface [nucleotide binding]; other site
106370004113	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
106370004114	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
106370004115	Walker A/P-loop; other site
106370004116	ATP binding site [chemical binding]; other site
106370004117	Q-loop/lid; other site
106370004118	ABC transporter signature motif; other site
106370004119	Walker B; other site
106370004120	D-loop; other site
106370004121	H-loop/switch region; other site
106370004122	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
106370004123	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
106370004124	dimer interface [polypeptide binding]; other site
106370004125	conserved gate region; other site
106370004126	putative PBP binding loops; other site
106370004127	ABC-ATPase subunit interface; other site
106370004128	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
106370004129	dimer interface [polypeptide binding]; other site
106370004130	conserved gate region; other site
106370004131	putative PBP binding loops; other site
106370004132	ABC-ATPase subunit interface; other site
106370004133	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
106370004134	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
106370004135	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
106370004136	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
106370004137	acyl-activating enzyme (AAE) consensus motif; other site
106370004138	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
106370004139	active site
106370004140	CoA binding site [chemical binding]; other site
106370004141	AMP binding site [chemical binding]; other site
106370004142	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
106370004143	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
106370004144	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
106370004145	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
106370004146	Walker A/P-loop; other site
106370004147	ATP binding site [chemical binding]; other site
106370004148	ABC transporter; Region: ABC_tran; pfam00005
106370004149	Q-loop/lid; other site
106370004150	ABC transporter signature motif; other site
106370004151	Walker B; other site
106370004152	D-loop; other site
106370004153	H-loop/switch region; other site
106370004154	Cytochrome P450; Region: p450; cl12078
106370004155	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
106370004156	Protein of unknown function (DUF1271); Region: DUF1271; pfam06902
106370004157	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
106370004158	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
106370004159	Interdomain contacts; other site
106370004160	Cytokine receptor motif; other site
106370004161	PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain.  Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543
106370004162	active site
106370004163	acyl-CoA synthetase; Validated; Region: PRK05850
106370004164	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
106370004165	acyl-activating enzyme (AAE) consensus motif; other site
106370004166	active site
106370004167	Thioesterase domain; Region: Thioesterase; pfam00975
106370004168	Serine hydrolase (FSH1); Region: FSH1; pfam03959
106370004169	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
106370004170	Cytochrome P450; Region: p450; cl12078
106370004171	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
106370004172	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370004173	S-adenosylmethionine binding site [chemical binding]; other site
106370004174	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
106370004175	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
106370004176	Fatty acid desaturase; Region: FA_desaturase; pfam00487
106370004177	Di-iron ligands [ion binding]; other site
106370004178	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
106370004179	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
106370004180	Cytochrome P450; Region: p450; cl12078
106370004181	Chromate transporter; Region: Chromate_transp; pfam02417
106370004182	Chromate transporter; Region: Chromate_transp; pfam02417
106370004183	Domain of unknown function (DUF305); Region: DUF305; pfam03713
106370004184	NlpC/P60 family; Region: NLPC_P60; cl17555
106370004185	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
106370004186	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
106370004187	metal binding site [ion binding]; metal-binding site
106370004188	active site
106370004189	I-site; other site
106370004190	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
106370004191	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
106370004192	S-adenosylmethionine binding site [chemical binding]; other site
106370004193	flavodoxin; Provisional; Region: PRK06242
106370004194	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
106370004195	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
106370004196	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
106370004197	active site
106370004198	phosphorylation site [posttranslational modification]
106370004199	intermolecular recognition site; other site
106370004200	dimerization interface [polypeptide binding]; other site
106370004201	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
106370004202	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
106370004203	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
106370004204	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
106370004205	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
106370004206	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
106370004207	dimerization interface [polypeptide binding]; other site
106370004208	ligand binding site [chemical binding]; other site
106370004209	DNA polymerase I; Provisional; Region: PRK05755
106370004210	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
106370004211	active site
106370004212	metal binding site 1 [ion binding]; metal-binding site
106370004213	putative 5' ssDNA interaction site; other site
106370004214	metal binding site 3; metal-binding site
106370004215	metal binding site 2 [ion binding]; metal-binding site
106370004216	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
106370004217	putative DNA binding site [nucleotide binding]; other site
106370004218	putative metal binding site [ion binding]; other site
106370004219	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
106370004220	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
106370004221	active site
106370004222	DNA binding site [nucleotide binding]
106370004223	catalytic site [active]
106370004224	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
106370004225	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
106370004226	metal binding site [ion binding]; metal-binding site
106370004227	active site
106370004228	I-site; other site
106370004229	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
106370004230	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
106370004231	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
106370004232	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
106370004233	active site
106370004234	Zn binding site [ion binding]; other site
106370004235	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
106370004236	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
106370004237	CoA-binding site [chemical binding]; other site
106370004238	ATP-binding [chemical binding]; other site
106370004239	excinuclease ABC subunit B; Provisional; Region: PRK05298
106370004240	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
106370004241	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
106370004242	nucleotide binding region [chemical binding]; other site
106370004243	ATP-binding site [chemical binding]; other site
106370004244	Ultra-violet resistance protein B; Region: UvrB; pfam12344
106370004245	UvrB/uvrC motif; Region: UVR; pfam02151
106370004246	FOG: CBS domain [General function prediction only]; Region: COG0517
106370004247	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
106370004248	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
106370004249	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
106370004250	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
106370004251	active site
106370004252	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
106370004253	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
106370004254	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
106370004255	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
106370004256	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
106370004257	Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686
106370004258	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
106370004259	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
106370004260	GIY-YIG motif/motif A; other site
106370004261	active site
106370004262	catalytic site [active]
106370004263	putative DNA binding site [nucleotide binding]; other site
106370004264	metal binding site [ion binding]; metal-binding site
106370004265	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
106370004266	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
106370004267	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
106370004268	phosphate binding site [ion binding]; other site
106370004269	putative substrate binding pocket [chemical binding]; other site
106370004270	dimer interface [polypeptide binding]; other site
106370004271	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
106370004272	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
106370004273	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
106370004274	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
106370004275	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
106370004276	Phosphoglycerate kinase; Region: PGK; pfam00162
106370004277	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
106370004278	substrate binding site [chemical binding]; other site
106370004279	hinge regions; other site
106370004280	ADP binding site [chemical binding]; other site
106370004281	catalytic site [active]
106370004282	triosephosphate isomerase; Provisional; Region: PRK14567
106370004283	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
106370004284	substrate binding site [chemical binding]; other site
106370004285	dimer interface [polypeptide binding]; other site
106370004286	catalytic triad [active]
106370004287	Preprotein translocase SecG subunit; Region: SecG; cl09123
106370004288	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
106370004289	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
106370004290	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
106370004291	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
106370004292	Catalytic domain of Protein Kinases; Region: PKc; cd00180
106370004293	active site
106370004294	ATP binding site [chemical binding]; other site
106370004295	substrate binding site [chemical binding]; other site
106370004296	activation loop (A-loop); other site
106370004297	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
106370004298	Short C-terminal domain; Region: SHOCT; pfam09851
106370004299	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
106370004300	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
106370004301	putative active site [active]
106370004302	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128
106370004303	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
106370004304	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
106370004305	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
106370004306	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
106370004307	putative active site [active]
106370004308	transaldolase; Provisional; Region: PRK03903
106370004309	catalytic residue [active]
106370004310	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
106370004311	UbiA prenyltransferase family; Region: UbiA; pfam01040
106370004312	Predicted flavoprotein [General function prediction only]; Region: COG0431
106370004313	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
106370004314	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
106370004315	ABC-2 type transporter; Region: ABC2_membrane; cl17235
106370004316	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
106370004317	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
106370004318	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
106370004319	Walker A/P-loop; other site
106370004320	ATP binding site [chemical binding]; other site
106370004321	Q-loop/lid; other site
106370004322	ABC transporter signature motif; other site
106370004323	Walker B; other site
106370004324	D-loop; other site
106370004325	H-loop/switch region; other site
106370004326	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
106370004327	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
106370004328	N- and C-terminal domain interface [polypeptide binding]; other site
106370004329	active site
106370004330	MgATP binding site [chemical binding]; other site
106370004331	catalytic site [active]
106370004332	metal binding site [ion binding]; metal-binding site
106370004333	glycerol binding site [chemical binding]; other site
106370004334	homotetramer interface [polypeptide binding]; other site
106370004335	homodimer interface [polypeptide binding]; other site
106370004336	FBP binding site [chemical binding]; other site
106370004337	protein IIAGlc interface [polypeptide binding]; other site
106370004338	Predicted transcriptional regulator [Transcription]; Region: COG2345
106370004339	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
106370004340	putative DNA binding site [nucleotide binding]; other site
106370004341	putative Zn2+ binding site [ion binding]; other site
106370004342	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
106370004343	FeS assembly protein SufB; Region: sufB; TIGR01980
106370004344	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
106370004345	FeS assembly protein SufD; Region: sufD; TIGR01981
106370004346	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
106370004347	[2Fe-2S] cluster binding site [ion binding]; other site
106370004348	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
106370004349	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
106370004350	Walker A/P-loop; other site
106370004351	ATP binding site [chemical binding]; other site
106370004352	Q-loop/lid; other site
106370004353	ABC transporter signature motif; other site
106370004354	Walker B; other site
106370004355	D-loop; other site
106370004356	H-loop/switch region; other site
106370004357	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
106370004358	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
106370004359	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
106370004360	catalytic residue [active]
106370004361	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
106370004362	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
106370004363	trimerization site [polypeptide binding]; other site
106370004364	active site
106370004365	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
106370004366	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
106370004367	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
106370004368	oligomer interface; other site
106370004369	ligand binding site; other site
106370004370	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
106370004371	dimer interface [polypeptide binding]; other site
106370004372	N-terminal domain interface [polypeptide binding]; other site
106370004373	sulfate 1 binding site; other site
106370004374	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
106370004375	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
106370004376	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
106370004377	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
106370004378	NAD binding site [chemical binding]; other site
106370004379	substrate binding site [chemical binding]; other site
106370004380	homodimer interface [polypeptide binding]; other site
106370004381	active site
106370004382	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
106370004383	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
106370004384	Walker A/P-loop; other site
106370004385	ATP binding site [chemical binding]; other site
106370004386	Q-loop/lid; other site
106370004387	ABC transporter signature motif; other site
106370004388	Walker B; other site
106370004389	D-loop; other site
106370004390	H-loop/switch region; other site
106370004391	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
106370004392	Cation efflux family; Region: Cation_efflux; pfam01545
106370004393	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
106370004394	trimer interface [polypeptide binding]; other site
106370004395	oxyanion hole (OAH) forming residues; other site
106370004396	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
106370004397	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
106370004398	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
106370004399	Walker A/P-loop; other site
106370004400	ATP binding site [chemical binding]; other site
106370004401	Q-loop/lid; other site
106370004402	ABC transporter signature motif; other site
106370004403	Walker B; other site
106370004404	D-loop; other site
106370004405	H-loop/switch region; other site
106370004406	pyruvate kinase; Provisional; Region: PRK06247
106370004407	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
106370004408	domain interfaces; other site
106370004409	active site
106370004410	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
106370004411	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
106370004412	active site
106370004413	phosphorylation site [posttranslational modification]
106370004414	intermolecular recognition site; other site
106370004415	dimerization interface [polypeptide binding]; other site
106370004416	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
106370004417	DNA binding residues [nucleotide binding]
106370004418	dimerization interface [polypeptide binding]; other site
106370004419	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
106370004420	oligomeric interface; other site
106370004421	putative active site [active]
106370004422	homodimer interface [polypeptide binding]; other site
106370004423	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
106370004424	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
106370004425	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
106370004426	catalytic residue [active]
106370004427	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
106370004428	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
106370004429	catalytic residues [active]
106370004430	catalytic nucleophile [active]
106370004431	Presynaptic Site I dimer interface [polypeptide binding]; other site
106370004432	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
106370004433	Synaptic Flat tetramer interface [polypeptide binding]; other site
106370004434	Synaptic Site I dimer interface [polypeptide binding]; other site
106370004435	DNA binding site [nucleotide binding]
106370004436	Recombinase; Region: Recombinase; pfam07508
106370004437	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
106370004438	Recombinase; Region: Recombinase; pfam07508
106370004439	PrgI family protein; Region: PrgI; pfam12666
106370004440	Domain of unknown function DUF87; Region: DUF87; pfam01935
106370004441	AAA-like domain; Region: AAA_10; pfam12846
106370004442	Domain of unknown function DUF87; Region: DUF87; pfam01935
106370004443	AAA-like domain; Region: AAA_10; pfam12846
106370004444	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
106370004445	Replication-relaxation; Region: Replic_Relax; pfam13814
106370004446	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
106370004447	N-acetyl-D-glucosamine binding site [chemical binding]; other site
106370004448	catalytic residue [active]
106370004449	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
106370004450	NlpC/P60 family; Region: NLPC_P60; pfam00877
106370004451	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370004452	non-specific DNA binding site [nucleotide binding]; other site
106370004453	salt bridge; other site
106370004454	sequence-specific DNA binding site [nucleotide binding]; other site
106370004455	DNA polymerase III subunit beta; Validated; Region: PRK07761
106370004456	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512
106370004457	putative DNA binding surface [nucleotide binding]; other site
106370004458	dimer interface [polypeptide binding]; other site
106370004459	beta-clamp/clamp loader binding surface; other site
106370004460	beta-clamp/translesion DNA polymerase binding surface; other site
106370004461	RecO N terminal; Region: RecO_N_2; cl15812
106370004462	phage/plasmid-like protein TIGR03299; Region: LGT_TIGR03299
106370004463	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
106370004464	Transposase; Region: HTH_Tnp_1; pfam01527
106370004465	putative transposase OrfB; Reviewed; Region: PHA02517
106370004466	HTH-like domain; Region: HTH_21; pfam13276
106370004467	Integrase core domain; Region: rve; pfam00665
106370004468	Integrase core domain; Region: rve_3; pfam13683
106370004469	DDE superfamily endonuclease; Region: DDE_5; pfam13546
106370004470	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
106370004471	Predicted transcriptional regulators [Transcription]; Region: COG1733
106370004472	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
106370004473	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
106370004474	Bacterial transcriptional activator domain; Region: BTAD; smart01043
106370004475	Type II/IV secretion system protein; Region: T2SE; pfam00437
106370004476	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
106370004477	ATP binding site [chemical binding]; other site
106370004478	Walker A motif; other site
106370004479	hexamer interface [polypeptide binding]; other site
106370004480	Walker B motif; other site
106370004481	AAA domain; Region: AAA_31; pfam13614
106370004482	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
106370004483	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
106370004484	AAA domain; Region: AAA_17; cl17253
106370004485	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
106370004486	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
106370004487	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
106370004488	GTP cyclohydrolase I [Coenzyme metabolism]; Region: FolE; COG0302
106370004489	GTP cyclohydrolase I; Provisional; Region: PLN03044
106370004490	active site
106370004491	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
106370004492	nudix motif; other site
106370004493	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
106370004494	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
106370004495	active site
106370004496	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843
106370004497	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
106370004498	active site
106370004499	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
106370004500	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
106370004501	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
106370004502	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
106370004503	substrate binding site [chemical binding]; other site
106370004504	ATP binding site [chemical binding]; other site
106370004505	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
106370004506	active site
106370004507	Sulfatase; Region: Sulfatase; cl17466
106370004508	transposase; Provisional; Region: PRK06526
106370004509	Amidinotransferase; Region: Amidinotransf; cl12043
106370004510	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
106370004511	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
106370004512	ATP binding site [chemical binding]; other site
106370004513	Mg2+ binding site [ion binding]; other site
106370004514	G-X-G motif; other site
106370004515	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
106370004516	anchoring element; other site
106370004517	dimer interface [polypeptide binding]; other site
106370004518	ATP binding site [chemical binding]; other site
106370004519	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
106370004520	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370004521	S-adenosylmethionine binding site [chemical binding]; other site
106370004522	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
106370004523	Rubrerythrin [Energy production and conversion]; Region: COG1592
106370004524	binuclear metal center [ion binding]; other site
106370004525	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
106370004526	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
106370004527	DDE superfamily endonuclease; Region: DDE_5; cl17874
106370004528	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
106370004529	Sulfatase; Region: Sulfatase; pfam00884
106370004530	Transcriptional regulators [Transcription]; Region: PurR; COG1609
106370004531	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
106370004532	DNA binding site [nucleotide binding]
106370004533	domain linker motif; other site
106370004534	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
106370004535	dimerization interface [polypeptide binding]; other site
106370004536	ligand binding site [chemical binding]; other site
106370004537	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
106370004538	metabolite-proton symporter; Region: 2A0106; TIGR00883
106370004539	putative substrate translocation pore; other site
106370004540	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
106370004541	Cytochrome P450; Region: p450; cl12078
106370004542	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
106370004543	active site
106370004544	Phosphotransferase enzyme family; Region: APH; pfam01636
106370004545	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
106370004546	active site
106370004547	ATP binding site [chemical binding]; other site
106370004548	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
106370004549	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
106370004550	Methyltransferase domain; Region: Methyltransf_31; pfam13847
106370004551	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370004552	S-adenosylmethionine binding site [chemical binding]; other site
106370004553	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
106370004554	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
106370004555	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
106370004556	FeS/SAM binding site; other site
106370004557	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
106370004558	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
106370004559	B12 binding domain; Region: B12-binding; pfam02310
106370004560	B12 binding site [chemical binding]; other site
106370004561	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
106370004562	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
106370004563	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
106370004564	Domain of unknown function (DUF397); Region: DUF397; pfam04149
106370004565	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
106370004566	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
106370004567	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
106370004568	DDE superfamily endonuclease; Region: DDE_4; pfam13359
106370004569	Replication-relaxation; Region: Replic_Relax; pfam13814
106370004570	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
106370004571	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
106370004572	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
106370004573	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
106370004574	active site
106370004575	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
106370004576	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
106370004577	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
106370004578	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
106370004579	substrate binding site [chemical binding]; other site
106370004580	hexamer interface [polypeptide binding]; other site
106370004581	metal binding site [ion binding]; metal-binding site
106370004582	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
106370004583	putative catalytic site [active]
106370004584	putative metal binding site [ion binding]; other site
106370004585	putative phosphate binding site [ion binding]; other site
106370004586	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
106370004587	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
106370004588	active site
106370004589	catalytic tetrad [active]
106370004590	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
106370004591	Radical SAM superfamily; Region: Radical_SAM; pfam04055
106370004592	TSCPD domain; Region: TSCPD; cl14834
106370004593	acyl-CoA synthetase; Validated; Region: PRK07798
106370004594	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
106370004595	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924
106370004596	acyl-activating enzyme (AAE) consensus motif; other site
106370004597	putative AMP binding site [chemical binding]; other site
106370004598	putative active site [active]
106370004599	putative CoA binding site [chemical binding]; other site
106370004600	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
106370004601	nucleotide binding site/active site [active]
106370004602	HIT family signature motif; other site
106370004603	catalytic residue [active]
106370004604	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
106370004605	active site
106370004606	CoA binding site [chemical binding]; other site
106370004607	AMP binding site [chemical binding]; other site
106370004608	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
106370004609	active site
106370004610	iron coordination sites [ion binding]; other site
106370004611	substrate binding pocket [chemical binding]; other site
106370004612	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
106370004613	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683
106370004614	nudix motif; other site
106370004615	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
106370004616	AAA domain; Region: AAA_28; pfam13521
106370004617	active site
106370004618	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
106370004619	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
106370004620	FeS/SAM binding site; other site
106370004621	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
106370004622	aromatic arch; other site
106370004623	DCoH dimer interaction site [polypeptide binding]; other site
106370004624	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
106370004625	DCoH tetramer interaction site [polypeptide binding]; other site
106370004626	substrate binding site [chemical binding]; other site
106370004627	Flavoprotein; Region: Flavoprotein; cl08021
106370004628	methyltransferase, FxLD system; Region: methyltran_FxLD; TIGR04364
106370004629	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370004630	S-adenosylmethionine binding site [chemical binding]; other site
106370004631	FxLD family lantipeptide; Region: LD_lanti_pre; TIGR04363
106370004632	Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737
106370004633	Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738
106370004634	thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891
106370004635	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
106370004636	active site
106370004637	zinc binding site [ion binding]; other site
106370004638	thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891
106370004639	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
106370004640	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
106370004641	Domain of unknown function (DUF1932); Region: DUF1932; pfam09130
106370004642	Pterin 4 alpha carbinolamine dehydratase; Region: Pterin_4a; pfam01329
106370004643	aromatic arch; other site
106370004644	DCoH dimer interaction site [polypeptide binding]; other site
106370004645	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
106370004646	DCoH tetramer interaction site [polypeptide binding]; other site
106370004647	substrate binding site [chemical binding]; other site
106370004648	pterin-4-alpha-carbinolamine dehydratase; Validated; Region: phhB; PRK00823
106370004649	aromatic arch; other site
106370004650	DCoH dimer interaction site [polypeptide binding]; other site
106370004651	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
106370004652	DCoH tetramer interaction site [polypeptide binding]; other site
106370004653	substrate binding site [chemical binding]; other site
106370004654	Phage-related protein [Function unknown]; Region: PblB; COG4926
106370004655	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
106370004656	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
106370004657	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
106370004658	TPR motif; other site
106370004659	binding surface
106370004660	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
106370004661	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
106370004662	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
106370004663	SpaB C-terminal domain; Region: SpaB_C; cl14828
106370004664	Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509
106370004665	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
106370004666	putative metal binding site [ion binding]; other site
106370004667	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; cl17639
106370004668	AAA domain; Region: AAA_33; pfam13671
106370004669	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
106370004670	Coenzyme A binding pocket [chemical binding]; other site
106370004671	Domain of unknown function (DUF4037); Region: DUF4037; pfam13228
106370004672	Helix-turn-helix domain; Region: HTH_17; pfam12728
106370004673	PIN domain; Region: PIN_3; pfam13470
106370004674	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
106370004675	ThiS family; Region: ThiS; pfam02597
106370004676	charged pocket; other site
106370004677	hydrophobic patch; other site
106370004678	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
106370004679	Cytochrome P450; Region: p450; cl12078
106370004680	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
106370004681	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
106370004682	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
106370004683	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
106370004684	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
106370004685	pyridoxal 5'-phosphate binding site [chemical binding]; other site
106370004686	homodimer interface [polypeptide binding]; other site
106370004687	catalytic residue [active]
106370004688	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
106370004689	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
106370004690	Radical SAM superfamily; Region: Radical_SAM; pfam04055
106370004691	FeS/SAM binding site; other site
106370004692	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
106370004693	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
106370004694	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
106370004695	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
106370004696	bacteriocin maturation radical SAM protein 1; Region: rSAM_ocin_1; TIGR03975
106370004697	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
106370004698	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
106370004699	active site
106370004700	HIGH motif; other site
106370004701	dimer interface [polypeptide binding]; other site
106370004702	KMSKS motif; other site
106370004703	Winged helix-turn helix; Region: HTH_29; pfam13551
106370004704	Homeodomain-like domain; Region: HTH_23; cl17451
106370004705	Winged helix-turn helix; Region: HTH_33; pfam13592
106370004706	DDE superfamily endonuclease; Region: DDE_3; pfam13358
106370004707	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
106370004708	active site
106370004709	DNA binding site [nucleotide binding]
106370004710	Int/Topo IB signature motif; other site
106370004711	Winged helix-turn helix; Region: HTH_29; pfam13551
106370004712	Homeodomain-like domain; Region: HTH_23; pfam13384
106370004713	Homeodomain-like domain; Region: HTH_32; pfam13565
106370004714	DDE superfamily endonuclease; Region: DDE_3; pfam13358
106370004715	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
106370004716	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
106370004717	Transposase domain (DUF772); Region: DUF772; pfam05598
106370004718	Transposase domain (DUF772); Region: DUF772; pfam05598
106370004719	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
106370004720	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
106370004721	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
106370004722	Coenzyme A binding pocket [chemical binding]; other site
106370004723	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
106370004724	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
106370004725	active site
106370004726	NTP binding site [chemical binding]; other site
106370004727	metal binding triad [ion binding]; metal-binding site
106370004728	antibiotic binding site [chemical binding]; other site
106370004729	Uncharacterized conserved protein [Function unknown]; Region: COG2361
106370004730	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282
106370004731	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
106370004732	DNA binding residues [nucleotide binding]
106370004733	putative dimer interface [polypeptide binding]; other site
106370004734	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
106370004735	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
106370004736	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
106370004737	Predicted flavoprotein [General function prediction only]; Region: COG0431
106370004738	Predicted dehydrogenase [General function prediction only]; Region: COG0579
106370004739	hydroxyglutarate oxidase; Provisional; Region: PRK11728
106370004740	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
106370004741	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
106370004742	Putative transmembrane protein (PGPGW); Region: PGPGW; pfam09656
106370004743	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
106370004744	TrkA-C domain; Region: TrkA_C; pfam02080
106370004745	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
106370004746	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
106370004747	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889
106370004748	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
106370004749	NAD(P) binding site [chemical binding]; other site
106370004750	active site
106370004751	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
106370004752	TPP-binding site [chemical binding]; other site
106370004753	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
106370004754	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
106370004755	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
106370004756	NAD(P) binding site [chemical binding]; other site
106370004757	active site
106370004758	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
106370004759	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
106370004760	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
106370004761	catalytic motif [active]
106370004762	Zn binding site [ion binding]; other site
106370004763	ferrochelatase; Reviewed; Region: hemH; PRK00035
106370004764	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
106370004765	C-terminal domain interface [polypeptide binding]; other site
106370004766	active site
106370004767	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
106370004768	active site
106370004769	N-terminal domain interface [polypeptide binding]; other site
106370004770	conserved hypothetical protein; Region: TIGR03847
106370004771	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
106370004772	active site
106370004773	catalytic triad [active]
106370004774	oxyanion hole [active]
106370004775	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
106370004776	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
106370004777	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
106370004778	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
106370004779	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
106370004780	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
106370004781	urate oxidase; Region: urate_oxi; TIGR03383
106370004782	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
106370004783	active site
106370004784	Bacterial Ig-like domain; Region: Big_5; pfam13205
106370004785	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
106370004786	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
106370004787	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
106370004788	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
106370004789	active site
106370004790	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
106370004791	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
106370004792	ligand binding site [chemical binding]; other site
106370004793	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
106370004794	Transcriptional regulators [Transcription]; Region: FadR; COG2186
106370004795	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
106370004796	DNA-binding site [nucleotide binding]; DNA binding site
106370004797	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
106370004798	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
106370004799	dimer interface [polypeptide binding]; other site
106370004800	active site
106370004801	heme binding site [chemical binding]; other site
106370004802	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
106370004803	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
106370004804	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
106370004805	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
106370004806	dimerization interface [polypeptide binding]; other site
106370004807	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
106370004808	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
106370004809	putative dimer interface [polypeptide binding]; other site
106370004810	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
106370004811	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
106370004812	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
106370004813	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
106370004814	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
106370004815	dinuclear metal binding motif [ion binding]; other site
106370004816	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
106370004817	dinuclear metal binding motif [ion binding]; other site
106370004818	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
106370004819	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370004820	S-adenosylmethionine binding site [chemical binding]; other site
106370004821	Phosphopantetheine attachment site; Region: PP-binding; cl09936
106370004822	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
106370004823	active site 2 [active]
106370004824	active site 1 [active]
106370004825	acyl-CoA synthetase; Validated; Region: PRK09192
106370004826	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
106370004827	acyl-activating enzyme (AAE) consensus motif; other site
106370004828	active site
106370004829	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
106370004830	Cytochrome P450; Region: p450; cl12078
106370004831	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
106370004832	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
106370004833	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
106370004834	dimerization interface [polypeptide binding]; other site
106370004835	substrate binding pocket [chemical binding]; other site
106370004836	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
106370004837	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
106370004838	acyl-activating enzyme (AAE) consensus motif; other site
106370004839	putative AMP binding site [chemical binding]; other site
106370004840	putative active site [active]
106370004841	putative CoA binding site [chemical binding]; other site
106370004842	Cytochrome P450; Region: p450; cl12078
106370004843	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
106370004844	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
106370004845	dimer interface [polypeptide binding]; other site
106370004846	active site
106370004847	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
106370004848	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
106370004849	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
106370004850	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
106370004851	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477
106370004852	nickel binding site [ion binding]; other site
106370004853	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
106370004854	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
106370004855	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
106370004856	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
106370004857	NifU-like domain; Region: NifU; cl00484
106370004858	magnesium chelatase subunit H; Provisional; Region: PRK12493
106370004859	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
106370004860	Acylphosphatase; Region: Acylphosphatase; pfam00708
106370004861	HypF finger; Region: zf-HYPF; pfam07503
106370004862	HypF finger; Region: zf-HYPF; pfam07503
106370004863	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
106370004864	HupF/HypC family; Region: HupF_HypC; pfam01455
106370004865	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
106370004866	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
106370004867	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
106370004868	dimerization interface [polypeptide binding]; other site
106370004869	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
106370004870	ATP binding site [chemical binding]; other site
106370004871	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
106370004872	DNA-binding site [nucleotide binding]; DNA binding site
106370004873	RNA-binding motif; other site
106370004874	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
106370004875	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
106370004876	TIR domain; Region: TIR_2; pfam13676
106370004877	Tetratricopeptide repeat; Region: TPR_12; pfam13424
106370004878	Tetratricopeptide repeat; Region: TPR_10; pfam13374
106370004879	Tetratricopeptide repeat; Region: TPR_12; pfam13424
106370004880	Tetratricopeptide repeat; Region: TPR_10; pfam13374
106370004881	Tetratricopeptide repeat; Region: TPR_10; pfam13374
106370004882	Integrase core domain; Region: rve; pfam00665
106370004883	Integrase core domain; Region: rve_3; pfam13683
106370004884	Transposase; Region: DEDD_Tnp_IS110; pfam01548
106370004885	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
106370004886	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
106370004887	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
106370004888	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
106370004889	catalytic residues [active]
106370004890	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
106370004891	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
106370004892	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
106370004893	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
106370004894	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
106370004895	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
106370004896	Cytochrome P450; Region: p450; cl12078
106370004897	Probable transposase; Region: OrfB_IS605; pfam01385
106370004898	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
106370004899	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
106370004900	Winged helix-turn helix; Region: HTH_29; pfam13551
106370004901	Helix-turn-helix domain; Region: HTH_28; pfam13518
106370004902	Homeodomain-like domain; Region: HTH_32; pfam13565
106370004903	DDE superfamily endonuclease; Region: DDE_3; pfam13358
106370004904	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
106370004905	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
106370004906	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
106370004907	putative active site [active]
106370004908	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
106370004909	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
106370004910	Condensation domain; Region: Condensation; pfam00668
106370004911	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
106370004912	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
106370004913	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
106370004914	acyl-activating enzyme (AAE) consensus motif; other site
106370004915	AMP binding site [chemical binding]; other site
106370004916	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
106370004917	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
106370004918	Ligand Binding Site [chemical binding]; other site
106370004919	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
106370004920	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
106370004921	active site
106370004922	Acyl transferase domain; Region: Acyl_transf_1; cl08282
106370004923	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
106370004924	Predicted membrane protein [Function unknown]; Region: COG4325
106370004925	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
106370004926	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
106370004927	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
106370004928	FAD binding domain; Region: FAD_binding_4; pfam01565
106370004929	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
106370004930	short chain dehydrogenase; Provisional; Region: PRK08267
106370004931	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
106370004932	putative NAD(P) binding site [chemical binding]; other site
106370004933	active site
106370004934	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_3; cd03328
106370004935	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
106370004936	putative active site pocket [active]
106370004937	putative metal binding site [ion binding]; other site
106370004938	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
106370004939	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
106370004940	protein binding site [polypeptide binding]; other site
106370004941	PAS fold; Region: PAS_4; pfam08448
106370004942	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
106370004943	putative active site [active]
106370004944	heme pocket [chemical binding]; other site
106370004945	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
106370004946	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
106370004947	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
106370004948	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
106370004949	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
106370004950	active site
106370004951	metal binding site [ion binding]; metal-binding site
106370004952	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
106370004953	substrate binding site [chemical binding]; other site
106370004954	THF binding site; other site
106370004955	zinc-binding site [ion binding]; other site
106370004956	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
106370004957	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
106370004958	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
106370004959	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
106370004960	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
106370004961	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
106370004962	Zn2+ binding site [ion binding]; other site
106370004963	Mg2+ binding site [ion binding]; other site
106370004964	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
106370004965	conserved cys residue [active]
106370004966	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
106370004967	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
106370004968	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
106370004969	putative substrate translocation pore; other site
106370004970	Major Facilitator Superfamily; Region: MFS_1; pfam07690
106370004971	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
106370004972	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
106370004973	homodimer interface [polypeptide binding]; other site
106370004974	substrate-cofactor binding pocket; other site
106370004975	pyridoxal 5'-phosphate binding site [chemical binding]; other site
106370004976	catalytic residue [active]
106370004977	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
106370004978	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
106370004979	conserved cys residue [active]
106370004980	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
106370004981	Major Facilitator Superfamily; Region: MFS_1; pfam07690
106370004982	putative substrate translocation pore; other site
106370004983	Predicted transcriptional regulators [Transcription]; Region: COG1733
106370004984	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
106370004985	Uncharacterized conserved protein [Function unknown]; Region: COG1359
106370004986	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
106370004987	FAD binding domain; Region: FAD_binding_4; pfam01565
106370004988	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
106370004989	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
106370004990	Transcriptional regulators [Transcription]; Region: GntR; COG1802
106370004991	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
106370004992	DNA-binding site [nucleotide binding]; DNA binding site
106370004993	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
106370004994	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
106370004995	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
106370004996	D-pathway; other site
106370004997	Putative ubiquinol binding site [chemical binding]; other site
106370004998	Low-spin heme (heme b) binding site [chemical binding]; other site
106370004999	Putative water exit pathway; other site
106370005000	Binuclear center (heme o3/CuB) [ion binding]; other site
106370005001	K-pathway; other site
106370005002	Putative proton exit pathway; other site
106370005003	LGFP repeat; Region: LGFP; pfam08310
106370005004	Transcriptional regulator [Transcription]; Region: IclR; COG1414
106370005005	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
106370005006	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
106370005007	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
106370005008	Major Facilitator Superfamily; Region: MFS_1; pfam07690
106370005009	putative substrate translocation pore; other site
106370005010	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
106370005011	MarR family; Region: MarR_2; pfam12802
106370005012	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
106370005013	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
106370005014	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
106370005015	catalytic residue [active]
106370005016	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
106370005017	NADH(P)-binding; Region: NAD_binding_10; pfam13460
106370005018	NAD(P) binding site [chemical binding]; other site
106370005019	active site
106370005020	Predicted transcriptional regulators [Transcription]; Region: COG1733
106370005021	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
106370005022	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
106370005023	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
106370005024	Walker A/P-loop; other site
106370005025	ATP binding site [chemical binding]; other site
106370005026	Q-loop/lid; other site
106370005027	ABC transporter signature motif; other site
106370005028	Walker B; other site
106370005029	D-loop; other site
106370005030	H-loop/switch region; other site
106370005031	ABC-2 type transporter; Region: ABC2_membrane; cl17235
106370005032	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
106370005033	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
106370005034	Predicted ATPase [General function prediction only]; Region: COG3903
106370005035	Tetratricopeptide repeat; Region: TPR_12; pfam13424
106370005036	Protein of unknown function (DUF2786); Region: DUF2786; pfam10979
106370005037	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
106370005038	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
106370005039	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
106370005040	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
106370005041	heme-binding site [chemical binding]; other site
106370005042	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
106370005043	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
106370005044	dimer interface [polypeptide binding]; other site
106370005045	PYR/PP interface [polypeptide binding]; other site
106370005046	TPP binding site [chemical binding]; other site
106370005047	substrate binding site [chemical binding]; other site
106370005048	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
106370005049	Domain of unknown function; Region: EKR; pfam10371
106370005050	4Fe-4S binding domain; Region: Fer4_6; pfam12837
106370005051	4Fe-4S binding domain; Region: Fer4; pfam00037
106370005052	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
106370005053	TPP-binding site [chemical binding]; other site
106370005054	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
106370005055	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
106370005056	P-loop; other site
106370005057	Magnesium ion binding site [ion binding]; other site
106370005058	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
106370005059	Magnesium ion binding site [ion binding]; other site
106370005060	thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891
106370005061	LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793
106370005062	active site
106370005063	zinc binding site [ion binding]; other site
106370005064	Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737
106370005065	Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738
106370005066	thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891
106370005067	methyltransferase, FxLD system; Region: methyltran_FxLD; TIGR04364
106370005068	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370005069	S-adenosylmethionine binding site [chemical binding]; other site
106370005070	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
106370005071	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
106370005072	NAD(P) binding site [chemical binding]; other site
106370005073	active site
106370005074	conserved hypothetical protein; Region: TIGR03843
106370005075	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
106370005076	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
106370005077	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
106370005078	Protein of unknown function (DUF3050); Region: DUF3050; pfam11251
106370005079	Uncharacterized conserved protein [Function unknown]; Region: COG2128
106370005080	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
106370005081	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
106370005082	Cytochrome P450; Region: p450; cl12078
106370005083	salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255
106370005084	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
106370005085	CoenzymeA binding site [chemical binding]; other site
106370005086	subunit interaction site [polypeptide binding]; other site
106370005087	PHB binding site; other site
106370005088	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
106370005089	putative substrate translocation pore; other site
106370005090	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
106370005091	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
106370005092	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
106370005093	acyl-activating enzyme (AAE) consensus motif; other site
106370005094	acyl-activating enzyme (AAE) consensus motif; other site
106370005095	putative AMP binding site [chemical binding]; other site
106370005096	putative active site [active]
106370005097	putative CoA binding site [chemical binding]; other site
106370005098	Phosphopantetheine attachment site; Region: PP-binding; cl09936
106370005099	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
106370005100	AMP-binding enzyme; Region: AMP-binding; pfam00501
106370005101	acyl-activating enzyme (AAE) consensus motif; other site
106370005102	active site
106370005103	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
106370005104	AMP-binding enzyme; Region: AMP-binding; pfam00501
106370005105	acyl-activating enzyme (AAE) consensus motif; other site
106370005106	AMP binding site [chemical binding]; other site
106370005107	active site
106370005108	CoA binding site [chemical binding]; other site
106370005109	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
106370005110	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
106370005111	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
106370005112	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899
106370005113	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
106370005114	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
106370005115	motif II; other site
106370005116	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
106370005117	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
106370005118	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
106370005119	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
106370005120	Winged helix-turn helix; Region: HTH_29; pfam13551
106370005121	Homeodomain-like domain; Region: HTH_23; pfam13384
106370005122	Homeodomain-like domain; Region: HTH_32; pfam13565
106370005123	DDE superfamily endonuclease; Region: DDE_3; pfam13358
106370005124	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
106370005125	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
106370005126	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
106370005127	DDE superfamily endonuclease; Region: DDE_4; pfam13359
106370005128	DDE superfamily endonuclease; Region: DDE_5; cl17874
106370005129	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
106370005130	ATP-grasp domain; Region: ATP-grasp_4; cl17255
106370005131	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
106370005132	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
106370005133	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
106370005134	catalytic residue [active]
106370005135	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
106370005136	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
106370005137	3-dehydroquinate synthase; Provisional; Region: PRK02290
106370005138	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
106370005139	putative active site; other site
106370005140	catalytic residue [active]
106370005141	aspartate kinase; Reviewed; Region: PRK06635
106370005142	AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246
106370005143	putative catalytic residues [active]
106370005144	putative nucleotide binding site [chemical binding]; other site
106370005145	putative aspartate binding site [chemical binding]; other site
106370005146	ATP-grasp domain; Region: ATP-grasp_4; cl17255
106370005147	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
106370005148	hypothetical protein; Provisional; Region: PRK06917
106370005149	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
106370005150	inhibitor-cofactor binding pocket; inhibition site
106370005151	pyridoxal 5'-phosphate binding site [chemical binding]; other site
106370005152	catalytic residue [active]
106370005153	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
106370005154	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
106370005155	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
106370005156	NACHT domain; Region: NACHT; pfam05729
106370005157	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
106370005158	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
106370005159	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
106370005160	conserved hypothetical protein; Region: TIGR03843
106370005161	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
106370005162	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
106370005163	SnoaL-like domain; Region: SnoaL_2; pfam12680
106370005164	Winged helix-turn helix; Region: HTH_29; pfam13551
106370005165	Helix-turn-helix domain; Region: HTH_28; pfam13518
106370005166	Homeodomain-like domain; Region: HTH_32; pfam13565
106370005167	DDE superfamily endonuclease; Region: DDE_3; pfam13358
106370005168	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
106370005169	putative substrate translocation pore; other site
106370005170	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
106370005171	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
106370005172	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
106370005173	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
106370005174	catalytic residues [active]
106370005175	catalytic nucleophile [active]
106370005176	Recombinase; Region: Recombinase; pfam07508
106370005177	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
106370005178	Helix-turn-helix domain; Region: HTH_17; pfam12728
106370005179	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
106370005180	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
106370005181	dimer interface [polypeptide binding]; other site
106370005182	active site
106370005183	CoA binding pocket [chemical binding]; other site
106370005184	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
106370005185	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
106370005186	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
106370005187	dimer interface [polypeptide binding]; other site
106370005188	active site
106370005189	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
106370005190	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
106370005191	active site
106370005192	catalytic tetrad [active]
106370005193	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
106370005194	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
106370005195	motif II; other site
106370005196	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
106370005197	active site
106370005198	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
106370005199	catalytic residues [active]
106370005200	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
106370005201	Asparagine synthase; Region: Asn_synthase; pfam00733
106370005202	Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471
106370005203	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
106370005204	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
106370005205	Recombinase; Region: Recombinase; pfam07508
106370005206	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
106370005207	catalytic nucleophile [active]
106370005208	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
106370005209	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
106370005210	FAD binding domain; Region: FAD_binding_3; pfam01494
106370005211	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
106370005212	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
106370005213	Isochorismatase family; Region: Isochorismatase; pfam00857
106370005214	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
106370005215	catalytic triad [active]
106370005216	conserved cis-peptide bond; other site
106370005217	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
106370005218	TAP-like protein; Region: Abhydrolase_4; pfam08386
106370005219	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
106370005220	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492
106370005221	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
106370005222	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
106370005223	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
106370005224	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
106370005225	putative PBP binding loops; other site
106370005226	ABC-ATPase subunit interface; other site
106370005227	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
106370005228	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
106370005229	Walker A/P-loop; other site
106370005230	ATP binding site [chemical binding]; other site
106370005231	Q-loop/lid; other site
106370005232	ABC transporter signature motif; other site
106370005233	Walker B; other site
106370005234	D-loop; other site
106370005235	H-loop/switch region; other site
106370005236	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
106370005237	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
106370005238	Walker A/P-loop; other site
106370005239	ATP binding site [chemical binding]; other site
106370005240	Q-loop/lid; other site
106370005241	ABC transporter signature motif; other site
106370005242	Walker B; other site
106370005243	D-loop; other site
106370005244	H-loop/switch region; other site
106370005245	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
106370005246	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
106370005247	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
106370005248	NAD(P) binding site [chemical binding]; other site
106370005249	active site
106370005250	A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756
106370005251	A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756
106370005252	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
106370005253	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
106370005254	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
106370005255	DNA binding site [nucleotide binding]
106370005256	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
106370005257	Tetratricopeptide repeat; Region: TPR_12; pfam13424
106370005258	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
106370005259	TPR motif; other site
106370005260	Tetratricopeptide repeat; Region: TPR_12; pfam13424
106370005261	binding surface
106370005262	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
106370005263	binding surface
106370005264	TPR motif; other site
106370005265	Tetratricopeptide repeat; Region: TPR_12; pfam13424
106370005266	Transposase; Region: DEDD_Tnp_IS110; pfam01548
106370005267	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
106370005268	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
106370005269	DDE superfamily endonuclease; Region: DDE_5; pfam13546
106370005270	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
106370005271	Helix-turn-helix domain; Region: HTH_28; pfam13518
106370005272	Winged helix-turn helix; Region: HTH_29; pfam13551
106370005273	Homeodomain-like domain; Region: HTH_32; pfam13565
106370005274	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
106370005275	putative active site [active]
106370005276	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
106370005277	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
106370005278	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
106370005279	Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861
106370005280	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
106370005281	Protein kinase domain; Region: Pkinase; pfam00069
106370005282	Catalytic domain of Protein Kinases; Region: PKc; cd00180
106370005283	active site
106370005284	ATP binding site [chemical binding]; other site
106370005285	substrate binding site [chemical binding]; other site
106370005286	activation loop (A-loop); other site
106370005287	Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145
106370005288	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
106370005289	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
106370005290	ATP binding site [chemical binding]; other site
106370005291	Mg2+ binding site [ion binding]; other site
106370005292	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
106370005293	GAF domain; Region: GAF; pfam01590
106370005294	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
106370005295	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
106370005296	Ligand Binding Site [chemical binding]; other site
106370005297	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
106370005298	Ligand Binding Site [chemical binding]; other site
106370005299	Hemerythrin-like domain; Region: Hr-like; cd12108
106370005300	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
106370005301	catalytic motif [active]
106370005302	Zn binding site [ion binding]; other site
106370005303	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
106370005304	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
106370005305	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
106370005306	active site
106370005307	catalytic residues [active]
106370005308	DNA binding site [nucleotide binding]
106370005309	Int/Topo IB signature motif; other site
106370005310	methyltransferase, FxLD system; Region: methyltran_FxLD; TIGR04364
106370005311	DDE superfamily endonuclease; Region: DDE_3; pfam13358
106370005312	Response regulator receiver domain; Region: Response_reg; pfam00072
106370005313	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
106370005314	active site
106370005315	phosphorylation site [posttranslational modification]
106370005316	intermolecular recognition site; other site
106370005317	dimerization interface [polypeptide binding]; other site
106370005318	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
106370005319	PAS domain; Region: PAS_9; pfam13426
106370005320	putative active site [active]
106370005321	heme pocket [chemical binding]; other site
106370005322	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
106370005323	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
106370005324	dimer interface [polypeptide binding]; other site
106370005325	phosphorylation site [posttranslational modification]
106370005326	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
106370005327	ATP binding site [chemical binding]; other site
106370005328	Mg2+ binding site [ion binding]; other site
106370005329	G-X-G motif; other site
106370005330	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
106370005331	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
106370005332	active site
106370005333	phosphorylation site [posttranslational modification]
106370005334	intermolecular recognition site; other site
106370005335	dimerization interface [polypeptide binding]; other site
106370005336	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
106370005337	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
106370005338	active site
106370005339	phosphorylation site [posttranslational modification]
106370005340	intermolecular recognition site; other site
106370005341	dimerization interface [polypeptide binding]; other site
106370005342	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
106370005343	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
106370005344	dimer interface [polypeptide binding]; other site
106370005345	phosphorylation site [posttranslational modification]
106370005346	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
106370005347	ATP binding site [chemical binding]; other site
106370005348	Mg2+ binding site [ion binding]; other site
106370005349	G-X-G motif; other site
106370005350	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
106370005351	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
106370005352	substrate binding pocket [chemical binding]; other site
106370005353	membrane-bound complex binding site; other site
106370005354	hinge residues; other site
106370005355	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
106370005356	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
106370005357	Walker A/P-loop; other site
106370005358	ATP binding site [chemical binding]; other site
106370005359	Q-loop/lid; other site
106370005360	ABC transporter signature motif; other site
106370005361	Walker B; other site
106370005362	D-loop; other site
106370005363	H-loop/switch region; other site
106370005364	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
106370005365	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
106370005366	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
106370005367	active site
106370005368	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
106370005369	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370005370	S-adenosylmethionine binding site [chemical binding]; other site
106370005371	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
106370005372	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
106370005373	NAD(P) binding site [chemical binding]; other site
106370005374	active site
106370005375	Transcriptional regulators [Transcription]; Region: PurR; COG1609
106370005376	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
106370005377	DNA binding site [nucleotide binding]
106370005378	domain linker motif; other site
106370005379	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
106370005380	dimerization interface [polypeptide binding]; other site
106370005381	ligand binding site [chemical binding]; other site
106370005382	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
106370005383	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
106370005384	acyl-activating enzyme (AAE) consensus motif; other site
106370005385	AMP binding site [chemical binding]; other site
106370005386	active site
106370005387	CoA binding site [chemical binding]; other site
106370005388	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
106370005389	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
106370005390	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
106370005391	active site
106370005392	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
106370005393	putative active site [active]
106370005394	putative catalytic site [active]
106370005395	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
106370005396	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
106370005397	B12 binding site [chemical binding]; other site
106370005398	ArgK protein; Region: ArgK; pfam03308
106370005399	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
106370005400	Walker A; other site
106370005401	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
106370005402	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
106370005403	HSP70 interaction site [polypeptide binding]; other site
106370005404	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
106370005405	substrate binding site [polypeptide binding]; other site
106370005406	dimer interface [polypeptide binding]; other site
106370005407	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
106370005408	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
106370005409	dimer interface [polypeptide binding]; other site
106370005410	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
106370005411	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
106370005412	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
106370005413	nucleotide binding site [chemical binding]; other site
106370005414	NEF interaction site [polypeptide binding]; other site
106370005415	SBD interface [polypeptide binding]; other site
106370005416	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
106370005417	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
106370005418	putative dimer interface [polypeptide binding]; other site
106370005419	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
106370005420	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
106370005421	ring oligomerisation interface [polypeptide binding]; other site
106370005422	ATP/Mg binding site [chemical binding]; other site
106370005423	stacking interactions; other site
106370005424	hinge regions; other site
106370005425	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
106370005426	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
106370005427	Uncharacterized conserved protein [Function unknown]; Region: COG1479
106370005428	Protein of unknown function DUF262; Region: DUF262; pfam03235
106370005429	Protein of unknown function DUF262; Region: DUF262; pfam03235
106370005430	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
106370005431	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
106370005432	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
106370005433	Magnesium ion binding site [ion binding]; other site
106370005434	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
106370005435	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
106370005436	Transcriptional regulators [Transcription]; Region: MarR; COG1846
106370005437	MarR family; Region: MarR_2; pfam12802
106370005438	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
106370005439	Sulfatase; Region: Sulfatase; pfam00884
106370005440	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
106370005441	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
106370005442	TAP-like protein; Region: Abhydrolase_4; pfam08386
106370005443	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
106370005444	Protein of unknown function DUF86; Region: DUF86; cl01031
106370005445	DDE superfamily endonuclease; Region: DDE_3; pfam13358
106370005446	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
106370005447	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
106370005448	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
106370005449	putative active site [active]
106370005450	putative NTP binding site [chemical binding]; other site
106370005451	putative nucleic acid binding site [nucleotide binding]; other site
106370005452	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
106370005453	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
106370005454	putative active site [active]
106370005455	Epoxide hydrolase N terminus; Region: EHN; pfam06441
106370005456	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
106370005457	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
106370005458	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
106370005459	tetramer interface [polypeptide binding]; other site
106370005460	active site
106370005461	Mg2+/Mn2+ binding site [ion binding]; other site
106370005462	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
106370005463	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
106370005464	Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913
106370005465	Predicted transcriptional regulators [Transcription]; Region: COG1733
106370005466	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
106370005467	dimerization interface [polypeptide binding]; other site
106370005468	putative DNA binding site [nucleotide binding]; other site
106370005469	putative Zn2+ binding site [ion binding]; other site
106370005470	Uncharacterized conserved protein [Function unknown]; Region: COG2353
106370005471	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
106370005472	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
106370005473	putative molybdopterin cofactor binding site; other site
106370005474	calcium-activated chloride channel protein 1; Region: hCaCC; TIGR00868
106370005475	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
106370005476	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
106370005477	catalytic residue [active]
106370005478	putative FPP diphosphate  binding site; other site
106370005479	putative FPP binding hydrophobic cleft; other site
106370005480	dimer interface [polypeptide binding]; other site
106370005481	putative IPP diphosphate binding site; other site
106370005482	Protein of unknown function (DUF1360); Region: DUF1360; pfam07098
106370005483	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
106370005484	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
106370005485	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
106370005486	CoenzymeA binding site [chemical binding]; other site
106370005487	subunit interaction site [polypeptide binding]; other site
106370005488	PHB binding site; other site
106370005489	Domain of unknown function (DUF222); Region: DUF222; pfam02720
106370005490	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
106370005491	active site
106370005492	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
106370005493	Transcriptional regulators [Transcription]; Region: MarR; COG1846
106370005494	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
106370005495	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
106370005496	Predicted membrane protein [Function unknown]; Region: COG3462
106370005497	Short C-terminal domain; Region: SHOCT; pfam09851
106370005498	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
106370005499	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
106370005500	heat shock protein HtpX; Provisional; Region: PRK02391
106370005501	Peptidase family M48; Region: Peptidase_M48; cl12018
106370005502	Penicillinase repressor; Region: Pencillinase_R; cl17580
106370005503	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
106370005504	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
106370005505	Walker A/P-loop; other site
106370005506	ATP binding site [chemical binding]; other site
106370005507	Q-loop/lid; other site
106370005508	ABC transporter signature motif; other site
106370005509	Walker B; other site
106370005510	D-loop; other site
106370005511	H-loop/switch region; other site
106370005512	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
106370005513	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
106370005514	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
106370005515	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
106370005516	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
106370005517	Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882
106370005518	Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647
106370005519	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
106370005520	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
106370005521	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
106370005522	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
106370005523	NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285
106370005524	tetramer interface [polypeptide binding]; other site
106370005525	catalytic Zn binding site [ion binding]; other site
106370005526	NADP binding site [chemical binding]; other site
106370005527	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
106370005528	acetyl-CoA acetyltransferase; Provisional; Region: PRK07516
106370005529	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
106370005530	active site
106370005531	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
106370005532	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
106370005533	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
106370005534	acyl-activating enzyme (AAE) consensus motif; other site
106370005535	acyl-activating enzyme (AAE) consensus motif; other site
106370005536	putative AMP binding site [chemical binding]; other site
106370005537	putative active site [active]
106370005538	putative CoA binding site [chemical binding]; other site
106370005539	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
106370005540	AAA ATPase domain; Region: AAA_16; pfam13191
106370005541	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
106370005542	DNA binding residues [nucleotide binding]
106370005543	dimerization interface [polypeptide binding]; other site
106370005544	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
106370005545	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
106370005546	active site
106370005547	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
106370005548	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
106370005549	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
106370005550	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
106370005551	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
106370005552	dimerization interface [polypeptide binding]; other site
106370005553	substrate binding pocket [chemical binding]; other site
106370005554	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
106370005555	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
106370005556	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
106370005557	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
106370005558	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
106370005559	dimer interface [polypeptide binding]; other site
106370005560	conserved gate region; other site
106370005561	putative PBP binding loops; other site
106370005562	ABC-ATPase subunit interface; other site
106370005563	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
106370005564	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
106370005565	dimer interface [polypeptide binding]; other site
106370005566	conserved gate region; other site
106370005567	putative PBP binding loops; other site
106370005568	ABC-ATPase subunit interface; other site
106370005569	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
106370005570	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
106370005571	Walker A/P-loop; other site
106370005572	ATP binding site [chemical binding]; other site
106370005573	Q-loop/lid; other site
106370005574	ABC transporter signature motif; other site
106370005575	Walker B; other site
106370005576	D-loop; other site
106370005577	H-loop/switch region; other site
106370005578	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
106370005579	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
106370005580	motif II; other site
106370005581	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
106370005582	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
106370005583	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
106370005584	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
106370005585	active site
106370005586	phosphorylation site [posttranslational modification]
106370005587	intermolecular recognition site; other site
106370005588	dimerization interface [polypeptide binding]; other site
106370005589	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
106370005590	DNA binding residues [nucleotide binding]
106370005591	dimerization interface [polypeptide binding]; other site
106370005592	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
106370005593	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
106370005594	ATP binding site [chemical binding]; other site
106370005595	putative Mg++ binding site [ion binding]; other site
106370005596	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
106370005597	nucleotide binding region [chemical binding]; other site
106370005598	ATP-binding site [chemical binding]; other site
106370005599	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
106370005600	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
106370005601	Fatty acid desaturase; Region: FA_desaturase; pfam00487
106370005602	Di-iron ligands [ion binding]; other site
106370005603	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
106370005604	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
106370005605	Presynaptic Site I dimer interface [polypeptide binding]; other site
106370005606	catalytic residues [active]
106370005607	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
106370005608	Synaptic Flat tetramer interface [polypeptide binding]; other site
106370005609	Synaptic Site I dimer interface [polypeptide binding]; other site
106370005610	DNA binding site [nucleotide binding]
106370005611	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
106370005612	DNA-binding interface [nucleotide binding]; DNA binding site
106370005613	Domain of unknown function (DUF397); Region: DUF397; pfam04149
106370005614	Domain of unknown function (DUF397); Region: DUF397; pfam04149
106370005615	methionine sulfoxide reductase B; Provisional; Region: PRK00222
106370005616	SelR domain; Region: SelR; pfam01641
106370005617	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
106370005618	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
106370005619	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
106370005620	Ligand binding site; other site
106370005621	Putative Catalytic site; other site
106370005622	DXD motif; other site
106370005623	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
106370005624	putative active site [active]
106370005625	catalytic triad [active]
106370005626	putative dimer interface [polypeptide binding]; other site
106370005627	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
106370005628	active site
106370005629	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
106370005630	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
106370005631	putative DNA binding site [nucleotide binding]; other site
106370005632	putative Zn2+ binding site [ion binding]; other site
106370005633	AsnC family; Region: AsnC_trans_reg; pfam01037
106370005634	5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739
106370005635	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
106370005636	active site
106370005637	metal binding site 1 [ion binding]; metal-binding site
106370005638	putative 5' ssDNA interaction site; other site
106370005639	metal binding site 3; metal-binding site
106370005640	metal binding site 2 [ion binding]; metal-binding site
106370005641	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
106370005642	putative DNA binding site [nucleotide binding]; other site
106370005643	putative metal binding site [ion binding]; other site
106370005644	fatty acyl-CoA reductase; Region: PLN02996
106370005645	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
106370005646	NAD(P) binding site [chemical binding]; other site
106370005647	active site
106370005648	C-terminal domain of fatty acyl CoA reductases; Region: FAR_C; cd09071
106370005649	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
106370005650	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
106370005651	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
106370005652	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
106370005653	NAD(P) binding site [chemical binding]; other site
106370005654	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
106370005655	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
106370005656	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
106370005657	putative acyl-acceptor binding pocket; other site
106370005658	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
106370005659	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370005660	non-specific DNA binding site [nucleotide binding]; other site
106370005661	salt bridge; other site
106370005662	sequence-specific DNA binding site [nucleotide binding]; other site
106370005663	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
106370005664	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
106370005665	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
106370005666	active site
106370005667	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
106370005668	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
106370005669	putative substrate translocation pore; other site
106370005670	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
106370005671	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108
106370005672	MarR family; Region: MarR; pfam01047
106370005673	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370005674	sequence-specific DNA binding site [nucleotide binding]; other site
106370005675	salt bridge; other site
106370005676	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
106370005677	hydrophobic ligand binding site; other site
106370005678	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
106370005679	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
106370005680	Retinal pigment epithelial membrane protein; Region: RPE65; cl10080
106370005681	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
106370005682	Retinal pigment epithelial membrane protein; Region: RPE65; cl10080
106370005683	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
106370005684	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
106370005685	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
106370005686	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
106370005687	catalytic triad [active]
106370005688	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
106370005689	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
106370005690	homodimer interface [polypeptide binding]; other site
106370005691	Walker A motif; other site
106370005692	ATP binding site [chemical binding]; other site
106370005693	hydroxycobalamin binding site [chemical binding]; other site
106370005694	Walker B motif; other site
106370005695	magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030
106370005696	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
106370005697	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
106370005698	metal ion-dependent adhesion site (MIDAS); other site
106370005699	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
106370005700	cyclase homology domain; Region: CHD; cd07302
106370005701	nucleotidyl binding site; other site
106370005702	metal binding site [ion binding]; metal-binding site
106370005703	dimer interface [polypeptide binding]; other site
106370005704	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
106370005705	active site
106370005706	DNA binding site [nucleotide binding]
106370005707	Int/Topo IB signature motif; other site
106370005708	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
106370005709	mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416
106370005710	Protein of unknown function (DUF2599); Region: DUF2599; pfam10783
106370005711	TIGR03086 family protein; Region: TIGR03086
106370005712	DinB superfamily; Region: DinB_2; pfam12867
106370005713	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
106370005714	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
106370005715	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
106370005716	Uncharacterized conserved protein [Function unknown]; Region: COG1262
106370005717	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
106370005718	FAD binding site [chemical binding]; other site
106370005719	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
106370005720	Protein of unknown function (DUF664); Region: DUF664; pfam04978
106370005721	DinB superfamily; Region: DinB_2; pfam12867
106370005722	Transposase; Region: DEDD_Tnp_IS110; pfam01548
106370005723	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
106370005724	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
106370005725	putative active site [active]
106370005726	putative NTP binding site [chemical binding]; other site
106370005727	putative nucleic acid binding site [nucleotide binding]; other site
106370005728	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
106370005729	PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993
106370005730	CrcB-like protein; Region: CRCB; pfam02537
106370005731	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
106370005732	Low molecular weight phosphatase family; Region: LMWPc; cd00115
106370005733	active site
106370005734	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
106370005735	amphipathic channel; other site
106370005736	Asn-Pro-Ala signature motifs; other site
106370005737	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
106370005738	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
106370005739	putative metal binding site [ion binding]; other site
106370005740	TAP-like protein; Region: Abhydrolase_4; pfam08386
106370005741	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
106370005742	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
106370005743	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
106370005744	PemK-like protein; Region: PemK; pfam02452
106370005745	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
106370005746	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
106370005747	acyl-activating enzyme (AAE) consensus motif; other site
106370005748	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
106370005749	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
106370005750	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
106370005751	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
106370005752	nudix motif; other site
106370005753	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
106370005754	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
106370005755	active site
106370005756	DNA binding site [nucleotide binding]
106370005757	Int/Topo IB signature motif; other site
106370005758	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
106370005759	DNA methylase; Region: N6_N4_Mtase; pfam01555
106370005760	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
106370005761	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
106370005762	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
106370005763	AAA domain; Region: AAA_33; pfam13671
106370005764	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
106370005765	catalytic core [active]
106370005766	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
106370005767	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
106370005768	catalytic residues [active]
106370005769	catalytic nucleophile [active]
106370005770	Presynaptic Site I dimer interface [polypeptide binding]; other site
106370005771	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
106370005772	Synaptic Flat tetramer interface [polypeptide binding]; other site
106370005773	Synaptic Site I dimer interface [polypeptide binding]; other site
106370005774	DNA binding site [nucleotide binding]
106370005775	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
106370005776	DNA-binding interface [nucleotide binding]; DNA binding site
106370005777	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
106370005778	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
106370005779	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
106370005780	active site
106370005781	metal binding site [ion binding]; metal-binding site
106370005782	interdomain interaction site; other site
106370005783	Zeta toxin; Region: Zeta_toxin; pfam06414
106370005784	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
106370005785	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
106370005786	AAA-like domain; Region: AAA_10; pfam12846
106370005787	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
106370005788	multiple promoter invertase; Provisional; Region: mpi; PRK13413
106370005789	catalytic residues [active]
106370005790	catalytic nucleophile [active]
106370005791	Presynaptic Site I dimer interface [polypeptide binding]; other site
106370005792	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
106370005793	Synaptic Flat tetramer interface [polypeptide binding]; other site
106370005794	Synaptic Site I dimer interface [polypeptide binding]; other site
106370005795	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
106370005796	DNA-binding interface [nucleotide binding]; DNA binding site
106370005797	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
106370005798	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
106370005799	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
106370005800	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
106370005801	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
106370005802	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
106370005803	HAMP domain; Region: HAMP; pfam00672
106370005804	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
106370005805	dimer interface [polypeptide binding]; other site
106370005806	phosphorylation site [posttranslational modification]
106370005807	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
106370005808	ATP binding site [chemical binding]; other site
106370005809	Mg2+ binding site [ion binding]; other site
106370005810	G-X-G motif; other site
106370005811	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
106370005812	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
106370005813	active site
106370005814	phosphorylation site [posttranslational modification]
106370005815	intermolecular recognition site; other site
106370005816	dimerization interface [polypeptide binding]; other site
106370005817	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
106370005818	DNA binding site [nucleotide binding]
106370005819	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705
106370005820	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
106370005821	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
106370005822	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
106370005823	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
106370005824	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
106370005825	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
106370005826	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
106370005827	catalytic residues [active]
106370005828	catalytic nucleophile [active]
106370005829	Recombinase; Region: Recombinase; pfam07508
106370005830	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
106370005831	active site
106370005832	ATP binding site [chemical binding]; other site
106370005833	Phosphotransferase enzyme family; Region: APH; pfam01636
106370005834	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
106370005835	substrate binding site [chemical binding]; other site
106370005836	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
106370005837	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
106370005838	Resolvase, N terminal domain; Region: Resolvase; smart00857
106370005839	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
106370005840	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
106370005841	active site
106370005842	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
106370005843	active site
106370005844	2-phosphoglycerate kinase; Provisional; Region: PRK12339
106370005845	Predicted nucleotidyltransferase [General function prediction    only]; Region: COG1665
106370005846	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
106370005847	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
106370005848	active site
106370005849	dimerization interface [polypeptide binding]; other site
106370005850	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_11; cd13126
106370005851	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
106370005852	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
106370005853	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
106370005854	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
106370005855	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
106370005856	XdhC Rossmann domain; Region: XdhC_C; pfam13478
106370005857	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
106370005858	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
106370005859	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
106370005860	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
106370005861	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
106370005862	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
106370005863	Part of AAA domain; Region: AAA_19; pfam13245
106370005864	Family description; Region: UvrD_C_2; pfam13538
106370005865	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
106370005866	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
106370005867	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
106370005868	active site
106370005869	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
106370005870	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
106370005871	phosphorylation site [posttranslational modification]
106370005872	dimer interface [polypeptide binding]; other site
106370005873	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
106370005874	ATP binding site [chemical binding]; other site
106370005875	Mg2+ binding site [ion binding]; other site
106370005876	G-X-G motif; other site
106370005877	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
106370005878	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
106370005879	active site
106370005880	phosphorylation site [posttranslational modification]
106370005881	intermolecular recognition site; other site
106370005882	dimerization interface [polypeptide binding]; other site
106370005883	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
106370005884	DNA binding site [nucleotide binding]
106370005885	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
106370005886	Bacitracin resistance protein BacA; Region: BacA; cl00858
106370005887	Amidase; Region: Amidase; cl11426
106370005888	Amidase; Region: Amidase; cl11426
106370005889	Amidase; Region: Amidase; cl11426
106370005890	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
106370005891	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
106370005892	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
106370005893	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
106370005894	AMP-binding enzyme; Region: AMP-binding; pfam00501
106370005895	acyl-activating enzyme (AAE) consensus motif; other site
106370005896	AMP binding site [chemical binding]; other site
106370005897	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
106370005898	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
106370005899	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
106370005900	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
106370005901	phosphate binding site [ion binding]; other site
106370005902	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
106370005903	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
106370005904	ATP binding site [chemical binding]; other site
106370005905	putative Mg++ binding site [ion binding]; other site
106370005906	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
106370005907	nucleotide binding region [chemical binding]; other site
106370005908	ATP-binding site [chemical binding]; other site
106370005909	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
106370005910	Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847
106370005911	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
106370005912	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
106370005913	H+ Antiporter protein; Region: 2A0121; TIGR00900
106370005914	putative substrate translocation pore; other site
106370005915	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
106370005916	FAD binding domain; Region: FAD_binding_4; pfam01565
106370005917	Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893
106370005918	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
106370005919	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
106370005920	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
106370005921	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
106370005922	active site residue [active]
106370005923	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
106370005924	active site residue [active]
106370005925	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
106370005926	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
106370005927	Q-loop/lid; other site
106370005928	ABC transporter signature motif; other site
106370005929	Walker B; other site
106370005930	D-loop; other site
106370005931	H-loop/switch region; other site
106370005932	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
106370005933	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
106370005934	Walker A/P-loop; other site
106370005935	ATP binding site [chemical binding]; other site
106370005936	Q-loop/lid; other site
106370005937	ABC transporter signature motif; other site
106370005938	Walker B; other site
106370005939	D-loop; other site
106370005940	H-loop/switch region; other site
106370005941	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
106370005942	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
106370005943	ABC-ATPase subunit interface; other site
106370005944	putative PBP binding loops; other site
106370005945	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
106370005946	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
106370005947	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
106370005948	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
106370005949	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
106370005950	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
106370005951	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
106370005952	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
106370005953	LysR substrate binding domain; Region: LysR_substrate; pfam03466
106370005954	dimerization interface [polypeptide binding]; other site
106370005955	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
106370005956	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
106370005957	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
106370005958	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
106370005959	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
106370005960	substrate binding pocket [chemical binding]; other site
106370005961	membrane-bound complex binding site; other site
106370005962	hinge residues; other site
106370005963	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
106370005964	Catalytic domain of Protein Kinases; Region: PKc; cd00180
106370005965	active site
106370005966	ATP binding site [chemical binding]; other site
106370005967	substrate binding site [chemical binding]; other site
106370005968	activation loop (A-loop); other site
106370005969	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
106370005970	Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
106370005971	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
106370005972	serine O-acetyltransferase; Region: cysE; TIGR01172
106370005973	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
106370005974	trimer interface [polypeptide binding]; other site
106370005975	active site
106370005976	substrate binding site [chemical binding]; other site
106370005977	CoA binding site [chemical binding]; other site
106370005978	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
106370005979	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
106370005980	dimer interface [polypeptide binding]; other site
106370005981	pyridoxal 5'-phosphate binding site [chemical binding]; other site
106370005982	catalytic residue [active]
106370005983	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
106370005984	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
106370005985	CoA-transferase family III; Region: CoA_transf_3; pfam02515
106370005986	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
106370005987	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
106370005988	active site
106370005989	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
106370005990	nudix motif; other site
106370005991	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
106370005992	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
106370005993	putative active site [active]
106370005994	catalytic site [active]
106370005995	putative metal binding site [ion binding]; other site
106370005996	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
106370005997	Catalytic domain of Protein Kinases; Region: PKc; cd00180
106370005998	active site
106370005999	ATP binding site [chemical binding]; other site
106370006000	substrate binding site [chemical binding]; other site
106370006001	activation loop (A-loop); other site
106370006002	HicB family; Region: HicB; pfam05534
106370006003	Uncharacterized conserved protein [Function unknown]; Region: COG3595
106370006004	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
106370006005	methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188
106370006006	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370006007	S-adenosylmethionine binding site [chemical binding]; other site
106370006008	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
106370006009	VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173
106370006010	Terminase-like family; Region: Terminase_6; pfam03237
106370006011	Phage terminase large subunit; Region: Terminase_3; cl12054
106370006012	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
106370006013	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
106370006014	active site
106370006015	phosphorylation site [posttranslational modification]
106370006016	intermolecular recognition site; other site
106370006017	dimerization interface [polypeptide binding]; other site
106370006018	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
106370006019	DNA binding site [nucleotide binding]
106370006020	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
106370006021	HAMP domain; Region: HAMP; pfam00672
106370006022	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
106370006023	dimer interface [polypeptide binding]; other site
106370006024	phosphorylation site [posttranslational modification]
106370006025	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
106370006026	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
106370006027	Walker A/P-loop; other site
106370006028	ATP binding site [chemical binding]; other site
106370006029	Q-loop/lid; other site
106370006030	ABC transporter signature motif; other site
106370006031	Walker B; other site
106370006032	D-loop; other site
106370006033	H-loop/switch region; other site
106370006034	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
106370006035	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
106370006036	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
106370006037	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
106370006038	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
106370006039	acyl-activating enzyme (AAE) consensus motif; other site
106370006040	AMP binding site [chemical binding]; other site
106370006041	Condensation domain; Region: Condensation; pfam00668
106370006042	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
106370006043	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
106370006044	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
106370006045	acyl-activating enzyme (AAE) consensus motif; other site
106370006046	AMP binding site [chemical binding]; other site
106370006047	Condensation domain; Region: Condensation; pfam00668
106370006048	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
106370006049	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
106370006050	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
106370006051	acyl-activating enzyme (AAE) consensus motif; other site
106370006052	AMP binding site [chemical binding]; other site
106370006053	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
106370006054	Condensation domain; Region: Condensation; pfam00668
106370006055	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
106370006056	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
106370006057	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
106370006058	acyl-activating enzyme (AAE) consensus motif; other site
106370006059	AMP binding site [chemical binding]; other site
106370006060	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
106370006061	Condensation domain; Region: Condensation; pfam00668
106370006062	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
106370006063	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251
106370006064	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
106370006065	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
106370006066	pyridoxal 5'-phosphate binding site [chemical binding]; other site
106370006067	homodimer interface [polypeptide binding]; other site
106370006068	catalytic residue [active]
106370006069	prephenate dehydrogenase; Validated; Region: PRK06545
106370006070	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
106370006071	prephenate dehydrogenase; Validated; Region: PRK08507
106370006072	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
106370006073	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
106370006074	dimer interface [polypeptide binding]; other site
106370006075	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
106370006076	active site
106370006077	Fe binding site [ion binding]; other site
106370006078	enoyl-CoA hydratase; Provisional; Region: PRK06494
106370006079	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
106370006080	substrate binding site [chemical binding]; other site
106370006081	oxyanion hole (OAH) forming residues; other site
106370006082	trimer interface [polypeptide binding]; other site
106370006083	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
106370006084	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
106370006085	substrate binding site [chemical binding]; other site
106370006086	oxyanion hole (OAH) forming residues; other site
106370006087	trimer interface [polypeptide binding]; other site
106370006088	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
106370006089	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
106370006090	substrate binding site [chemical binding]; other site
106370006091	oxyanion hole (OAH) forming residues; other site
106370006092	trimer interface [polypeptide binding]; other site
106370006093	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
106370006094	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
106370006095	malonyl-CoA binding site [chemical binding]; other site
106370006096	dimer interface [polypeptide binding]; other site
106370006097	active site
106370006098	product binding site; other site
106370006099	Condensation domain; Region: Condensation; pfam00668
106370006100	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
106370006101	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
106370006102	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
106370006103	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
106370006104	acyl-activating enzyme (AAE) consensus motif; other site
106370006105	AMP binding site [chemical binding]; other site
106370006106	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
106370006107	Condensation domain; Region: Condensation; pfam00668
106370006108	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
106370006109	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
106370006110	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
106370006111	acyl-activating enzyme (AAE) consensus motif; other site
106370006112	AMP binding site [chemical binding]; other site
106370006113	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
106370006114	Condensation domain; Region: Condensation; pfam00668
106370006115	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
106370006116	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
106370006117	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
106370006118	acyl-activating enzyme (AAE) consensus motif; other site
106370006119	AMP binding site [chemical binding]; other site
106370006120	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
106370006121	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
106370006122	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
106370006123	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
106370006124	acyl-activating enzyme (AAE) consensus motif; other site
106370006125	AMP binding site [chemical binding]; other site
106370006126	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
106370006127	Condensation domain; Region: Condensation; pfam00668
106370006128	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
106370006129	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
106370006130	acyl-activating enzyme (AAE) consensus motif; other site
106370006131	AMP binding site [chemical binding]; other site
106370006132	Condensation domain; Region: Condensation; pfam00668
106370006133	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
106370006134	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
106370006135	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
106370006136	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
106370006137	acyl-activating enzyme (AAE) consensus motif; other site
106370006138	AMP binding site [chemical binding]; other site
106370006139	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
106370006140	Condensation domain; Region: Condensation; pfam00668
106370006141	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
106370006142	Condensation domain; Region: Condensation; pfam00668
106370006143	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
106370006144	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
106370006145	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
106370006146	acyl-activating enzyme (AAE) consensus motif; other site
106370006147	AMP binding site [chemical binding]; other site
106370006148	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
106370006149	Condensation domain; Region: Condensation; pfam00668
106370006150	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
106370006151	Condensation domain; Region: Condensation; pfam00668
106370006152	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
106370006153	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
106370006154	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
106370006155	acyl-activating enzyme (AAE) consensus motif; other site
106370006156	AMP binding site [chemical binding]; other site
106370006157	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
106370006158	Condensation domain; Region: Condensation; pfam00668
106370006159	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
106370006160	Condensation domain; Region: Condensation; pfam00668
106370006161	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
106370006162	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
106370006163	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
106370006164	acyl-activating enzyme (AAE) consensus motif; other site
106370006165	AMP binding site [chemical binding]; other site
106370006166	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
106370006167	Condensation domain; Region: Condensation; pfam00668
106370006168	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
106370006169	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
106370006170	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
106370006171	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
106370006172	Walker A/P-loop; other site
106370006173	ATP binding site [chemical binding]; other site
106370006174	Q-loop/lid; other site
106370006175	ABC transporter signature motif; other site
106370006176	Walker B; other site
106370006177	D-loop; other site
106370006178	H-loop/switch region; other site
106370006179	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
106370006180	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
106370006181	active site
106370006182	substrate binding site [chemical binding]; other site
106370006183	FMN binding site [chemical binding]; other site
106370006184	putative catalytic residues [active]
106370006185	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
106370006186	homotrimer interaction site [polypeptide binding]; other site
106370006187	active site
106370006188	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
106370006189	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
106370006190	ParB-like nuclease domain; Region: ParB; smart00470
106370006191	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
106370006192	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
106370006193	carbon starvation protein A; Provisional; Region: PRK15015
106370006194	Carbon starvation protein CstA; Region: CstA; pfam02554
106370006195	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
106370006196	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
106370006197	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
106370006198	Na binding site [ion binding]; other site
106370006199	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
106370006200	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
106370006201	DNA binding residues [nucleotide binding]
106370006202	lipid-transfer protein; Provisional; Region: PRK08256
106370006203	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
106370006204	active site
106370006205	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
106370006206	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
106370006207	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
106370006208	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
106370006209	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
106370006210	ABC-ATPase subunit  interface; other site
106370006211	dimer interface [polypeptide binding]; other site
106370006212	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
106370006213	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
106370006214	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
106370006215	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
106370006216	Walker A/P-loop; other site
106370006217	ATP binding site [chemical binding]; other site
106370006218	Q-loop/lid; other site
106370006219	ABC transporter signature motif; other site
106370006220	Walker B; other site
106370006221	D-loop; other site
106370006222	H-loop/switch region; other site
106370006223	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
106370006224	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
106370006225	intersubunit interface [polypeptide binding]; other site
106370006226	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
106370006227	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
106370006228	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
106370006229	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
106370006230	putative active site [active]
106370006231	putative metal binding site [ion binding]; other site
106370006232	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
106370006233	prephenate dehydratase; Provisional; Region: PRK11898
106370006234	Prephenate dehydratase; Region: PDT; pfam00800
106370006235	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
106370006236	putative L-Phe binding site [chemical binding]; other site
106370006237	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
106370006238	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
106370006239	E3 interaction surface; other site
106370006240	lipoyl attachment site [posttranslational modification]; other site
106370006241	e3 binding domain; Region: E3_binding; pfam02817
106370006242	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
106370006243	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
106370006244	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
106370006245	alpha subunit interface [polypeptide binding]; other site
106370006246	TPP binding site [chemical binding]; other site
106370006247	heterodimer interface [polypeptide binding]; other site
106370006248	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
106370006249	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
106370006250	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
106370006251	tetramer interface [polypeptide binding]; other site
106370006252	TPP-binding site [chemical binding]; other site
106370006253	heterodimer interface [polypeptide binding]; other site
106370006254	phosphorylation loop region [posttranslational modification]
106370006255	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
106370006256	heme bH binding site [chemical binding]; other site
106370006257	intrachain domain interface; other site
106370006258	heme bL binding site [chemical binding]; other site
106370006259	interchain domain interface [polypeptide binding]; other site
106370006260	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
106370006261	Qo binding site; other site
106370006262	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
106370006263	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
106370006264	iron-sulfur cluster [ion binding]; other site
106370006265	[2Fe-2S] cluster binding site [ion binding]; other site
106370006266	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
106370006267	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
106370006268	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
106370006269	D-pathway; other site
106370006270	Putative ubiquinol binding site [chemical binding]; other site
106370006271	Low-spin heme (heme b) binding site [chemical binding]; other site
106370006272	Putative water exit pathway; other site
106370006273	Binuclear center (heme o3/CuB) [ion binding]; other site
106370006274	K-pathway; other site
106370006275	Putative proton exit pathway; other site
106370006276	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
106370006277	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
106370006278	thiamine pyrophosphate protein; Provisional; Region: PRK08273
106370006279	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
106370006280	PYR/PP interface [polypeptide binding]; other site
106370006281	dimer interface [polypeptide binding]; other site
106370006282	tetramer interface [polypeptide binding]; other site
106370006283	TPP binding site [chemical binding]; other site
106370006284	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
106370006285	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
106370006286	TPP-binding site [chemical binding]; other site
106370006287	hopanoid C-3 methylase HpnR; Region: HpnR_B12_rSAM; TIGR04367
106370006288	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
106370006289	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
106370006290	FeS/SAM binding site; other site
106370006291	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
106370006292	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
106370006293	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
106370006294	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
106370006295	Cu(I) binding site [ion binding]; other site
106370006296	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
106370006297	MarR family; Region: MarR; pfam01047
106370006298	putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862
106370006299	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
106370006300	Cl- selectivity filter; other site
106370006301	Cl- binding residues [ion binding]; other site
106370006302	pore gating glutamate residue; other site
106370006303	dimer interface [polypeptide binding]; other site
106370006304	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in bacteria and archaea. These ion channels are proteins with a seemingly simple task of allowing the passive flow of...; Region: CBS_pair_EriC_assoc_bac_arch; cd04593
106370006305	acetyl-CoA acetyltransferase; Provisional; Region: PRK07516
106370006306	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
106370006307	active site
106370006308	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
106370006309	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
106370006310	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
106370006311	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
106370006312	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
106370006313	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
106370006314	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
106370006315	Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882
106370006316	Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647
106370006317	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
106370006318	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
106370006319	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
106370006320	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
106370006321	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
106370006322	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
106370006323	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
106370006324	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
106370006325	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
106370006326	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
106370006327	chaperonin GroEL; Reviewed; Region: groEL; PRK12851
106370006328	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
106370006329	ring oligomerisation interface [polypeptide binding]; other site
106370006330	ATP/Mg binding site [chemical binding]; other site
106370006331	stacking interactions; other site
106370006332	hinge regions; other site
106370006333	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
106370006334	D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284
106370006335	NAD binding site [chemical binding]; other site
106370006336	substrate binding site [chemical binding]; other site
106370006337	catalytic Zn binding site [ion binding]; other site
106370006338	structural Zn binding site [ion binding]; other site
106370006339	Domain of unknown function DUF59; Region: DUF59; pfam01883
106370006340	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
106370006341	active site
106370006342	MmoB/DmpM family; Region: MmoB_DmpM; pfam02406
106370006343	Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058
106370006344	dimerization interface [polypeptide binding]; other site
106370006345	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
106370006346	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
106370006347	catalytic loop [active]
106370006348	iron binding site [ion binding]; other site
106370006349	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons. These flavoprotein monooxygenases use molecular oxygen as a substrate and require reduced FAD. One atom of oxygen is...; Region: monooxygenase_like; cd06212
106370006350	FAD binding pocket [chemical binding]; other site
106370006351	FAD binding motif [chemical binding]; other site
106370006352	phosphate binding motif [ion binding]; other site
106370006353	beta-alpha-beta structure motif; other site
106370006354	NAD binding pocket [chemical binding]; other site
106370006355	Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057
106370006356	dimerization interface [polypeptide binding]; other site
106370006357	putative path to active site cavity [active]
106370006358	diiron center [ion binding]; other site
106370006359	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
106370006360	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
106370006361	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
106370006362	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
106370006363	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
106370006364	metal binding site [ion binding]; metal-binding site
106370006365	active site
106370006366	I-site; other site
106370006367	uncharacterized HhH-GPD family protein; Region: TIGR03252
106370006368	minor groove reading motif; other site
106370006369	helix-hairpin-helix signature motif; other site
106370006370	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
106370006371	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
106370006372	NAD(P) binding site [chemical binding]; other site
106370006373	active site
106370006374	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
106370006375	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
106370006376	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
106370006377	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
106370006378	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
106370006379	catalytic residues [active]
106370006380	Recombinase; Region: Recombinase; pfam07508
106370006381	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
106370006382	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
106370006383	DDE superfamily endonuclease; Region: DDE_4; pfam13359
106370006384	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
106370006385	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
106370006386	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
106370006387	DDE superfamily endonuclease; Region: DDE_4; pfam13359
106370006388	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
106370006389	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
106370006390	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
106370006391	DDE superfamily endonuclease; Region: DDE_5; cl17874
106370006392	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
106370006393	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
106370006394	ATP binding site [chemical binding]; other site
106370006395	Mg2+ binding site [ion binding]; other site
106370006396	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
106370006397	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
106370006398	Helix-turn-helix domain; Region: HTH_19; pfam12844
106370006399	conserved hypothetical protein; Region: TIGR03843
106370006400	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
106370006401	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
106370006402	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
106370006403	adenylate kinase; Region: adk; TIGR01351
106370006404	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
106370006405	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
106370006406	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
106370006407	FeS/SAM binding site; other site
106370006408	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
106370006409	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
106370006410	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
106370006411	ATP binding site [chemical binding]; other site
106370006412	substrate binding site [chemical binding]; other site
106370006413	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
106370006414	DDE superfamily endonuclease; Region: DDE_4; pfam13359
106370006415	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683
106370006416	nudix motif; other site
106370006417	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
106370006418	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
106370006419	catalytic residues [active]
106370006420	Recombinase; Region: Recombinase; pfam07508
106370006421	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
106370006422	DDE superfamily endonuclease; Region: DDE_4; cl17710
106370006423	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
106370006424	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
106370006425	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
106370006426	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
106370006427	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
106370006428	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
106370006429	conserved cys residue [active]
106370006430	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
106370006431	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
106370006432	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
106370006433	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370006434	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
106370006435	salt bridge; other site
106370006436	non-specific DNA binding site [nucleotide binding]; other site
106370006437	sequence-specific DNA binding site [nucleotide binding]; other site
106370006438	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
106370006439	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
106370006440	PIN domain; Region: PIN; pfam01850
106370006441	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
106370006442	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
106370006443	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
106370006444	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
106370006445	LabA_like proteins; Region: LabA_like; cd06167
106370006446	Uncharacterized conserved protein [Function unknown]; Region: COG1432
106370006447	putative metal binding site [ion binding]; other site
106370006448	Recombinase; Region: Recombinase; pfam07508
106370006449	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
106370006450	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
106370006451	CHAT domain; Region: CHAT; pfam12770
106370006452	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
106370006453	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
106370006454	apolar tunnel; other site
106370006455	heme binding site [chemical binding]; other site
106370006456	dimerization interface [polypeptide binding]; other site
106370006457	pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853
106370006458	ApbE family; Region: ApbE; pfam02424
106370006459	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
106370006460	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
106370006461	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
106370006462	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
106370006463	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
106370006464	active site
106370006465	metal binding site [ion binding]; metal-binding site
106370006466	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
106370006467	salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255
106370006468	hypothetical protein; Provisional; Region: PRK07236
106370006469	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
106370006470	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
106370006471	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
106370006472	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
106370006473	FeS/SAM binding site; other site
106370006474	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
106370006475	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
106370006476	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
106370006477	dimer interface [polypeptide binding]; other site
106370006478	active site
106370006479	PAS fold; Region: PAS_4; pfam08448
106370006480	GAF domain; Region: GAF_2; pfam13185
106370006481	GAF domain; Region: GAF; cl17456
106370006482	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
106370006483	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
106370006484	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
106370006485	dimerization interface [polypeptide binding]; other site
106370006486	putative DNA binding site [nucleotide binding]; other site
106370006487	putative Zn2+ binding site [ion binding]; other site
106370006488	Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462
106370006489	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
106370006490	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
106370006491	active site
106370006492	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
106370006493	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
106370006494	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
106370006495	Walker A/P-loop; other site
106370006496	ATP binding site [chemical binding]; other site
106370006497	Q-loop/lid; other site
106370006498	ABC transporter signature motif; other site
106370006499	Walker B; other site
106370006500	D-loop; other site
106370006501	H-loop/switch region; other site
106370006502	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
106370006503	cobyric acid synthase; Provisional; Region: PRK00784
106370006504	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
106370006505	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
106370006506	catalytic triad [active]
106370006507	CobD/Cbib protein; Region: CobD_Cbib; cl00561
106370006508	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
106370006509	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
106370006510	ATP binding site [chemical binding]; other site
106370006511	putative Mg++ binding site [ion binding]; other site
106370006512	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
106370006513	nucleotide binding region [chemical binding]; other site
106370006514	ATP-binding site [chemical binding]; other site
106370006515	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
106370006516	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
106370006517	mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416
106370006518	Predicted transcriptional regulator [Transcription]; Region: COG2378
106370006519	WYL domain; Region: WYL; pfam13280
106370006520	Predicted transcriptional regulator [Transcription]; Region: COG2378
106370006521	WYL domain; Region: WYL; pfam13280
106370006522	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
106370006523	proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686
106370006524	Dienelactone hydrolase family; Region: DLH; pfam01738
106370006525	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
106370006526	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
106370006527	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
106370006528	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
106370006529	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
106370006530	Predicted membrane protein [Function unknown]; Region: COG2119
106370006531	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
106370006532	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
106370006533	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
106370006534	oligomeric interface; other site
106370006535	putative active site [active]
106370006536	homodimer interface [polypeptide binding]; other site
106370006537	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
106370006538	Coenzyme A binding pocket [chemical binding]; other site
106370006539	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672
106370006540	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
106370006541	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
106370006542	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
106370006543	Walker A/P-loop; other site
106370006544	ATP binding site [chemical binding]; other site
106370006545	Q-loop/lid; other site
106370006546	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
106370006547	ABC transporter signature motif; other site
106370006548	Walker B; other site
106370006549	D-loop; other site
106370006550	H-loop/switch region; other site
106370006551	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
106370006552	Walker A/P-loop; other site
106370006553	ATP binding site [chemical binding]; other site
106370006554	Q-loop/lid; other site
106370006555	ABC transporter signature motif; other site
106370006556	Walker B; other site
106370006557	D-loop; other site
106370006558	H-loop/switch region; other site
106370006559	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
106370006560	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
106370006561	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
106370006562	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
106370006563	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
106370006564	short chain dehydrogenase; Provisional; Region: PRK07041
106370006565	NAD(P) binding site [chemical binding]; other site
106370006566	active site
106370006567	proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691
106370006568	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
106370006569	active site
106370006570	proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690
106370006571	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
106370006572	active site
106370006573	Pup-like protein; Region: Pup; pfam05639
106370006574	proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688
106370006575	proteasome ATPase; Region: pup_AAA; TIGR03689
106370006576	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
106370006577	Walker A motif; other site
106370006578	ATP binding site [chemical binding]; other site
106370006579	Walker B motif; other site
106370006580	arginine finger; other site
106370006581	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
106370006582	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
106370006583	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370006584	S-adenosylmethionine binding site [chemical binding]; other site
106370006585	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
106370006586	active site
106370006587	putative substrate binding region [chemical binding]; other site
106370006588	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
106370006589	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
106370006590	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
106370006591	Walker A/P-loop; other site
106370006592	ATP binding site [chemical binding]; other site
106370006593	Q-loop/lid; other site
106370006594	ABC transporter signature motif; other site
106370006595	Walker B; other site
106370006596	D-loop; other site
106370006597	H-loop/switch region; other site
106370006598	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
106370006599	FtsX-like permease family; Region: FtsX; pfam02687
106370006600	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
106370006601	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
106370006602	FtsX-like permease family; Region: FtsX; pfam02687
106370006603	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
106370006604	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
106370006605	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
106370006606	motif II; other site
106370006607	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
106370006608	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
106370006609	PAC2 family; Region: PAC2; pfam09754
106370006610	DivIVA protein; Region: DivIVA; pfam05103
106370006611	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
106370006612	cysteinyl-tRNA synthetase; Provisional; Region: PRK12418
106370006613	active site
106370006614	HIGH motif; other site
106370006615	nucleotide binding site [chemical binding]; other site
106370006616	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
106370006617	active site
106370006618	KMSKS motif; other site
106370006619	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
106370006620	tRNA binding surface [nucleotide binding]; other site
106370006621	anticodon binding site; other site
106370006622	conserved hypothetical protein; Region: TIGR03843
106370006623	conserved hypothetical protein; Region: TIGR03847
106370006624	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
106370006625	catalytic core [active]
106370006626	AAA domain; Region: AAA_30; pfam13604
106370006627	Family description; Region: UvrD_C_2; pfam13538
106370006628	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
106370006629	hypothetical protein; Provisional; Region: PRK07208
106370006630	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
106370006631	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
106370006632	hypothetical protein; Provisional; Region: PRK07906
106370006633	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
106370006634	putative metal binding site [ion binding]; other site
106370006635	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
106370006636	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
106370006637	tetramer interface [polypeptide binding]; other site
106370006638	active site
106370006639	Mg2+/Mn2+ binding site [ion binding]; other site
106370006640	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
106370006641	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
106370006642	active site
106370006643	SAM binding site [chemical binding]; other site
106370006644	homodimer interface [polypeptide binding]; other site
106370006645	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
106370006646	FAD binding domain; Region: FAD_binding_4; pfam01565
106370006647	probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621
106370006648	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
106370006649	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
106370006650	active site
106370006651	catalytic residues [active]
106370006652	metal binding site [ion binding]; metal-binding site
106370006653	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
106370006654	metal binding site 2 [ion binding]; metal-binding site
106370006655	putative DNA binding helix; other site
106370006656	metal binding site 1 [ion binding]; metal-binding site
106370006657	dimer interface [polypeptide binding]; other site
106370006658	structural Zn2+ binding site [ion binding]; other site
106370006659	UGMP family protein; Validated; Region: PRK09604
106370006660	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
106370006661	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
106370006662	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
106370006663	Cytochrome P450; Region: p450; cl12078
106370006664	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
106370006665	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
106370006666	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
106370006667	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
106370006668	homodimer interface [polypeptide binding]; other site
106370006669	NADP binding site [chemical binding]; other site
106370006670	substrate binding site [chemical binding]; other site
106370006671	topology modulation protein; Reviewed; Region: PRK08118
106370006672	AAA domain; Region: AAA_17; pfam13207
106370006673	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
106370006674	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
106370006675	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
106370006676	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
106370006677	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
106370006678	Walker A/P-loop; other site
106370006679	ATP binding site [chemical binding]; other site
106370006680	Q-loop/lid; other site
106370006681	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
106370006682	ABC transporter signature motif; other site
106370006683	Walker B; other site
106370006684	D-loop; other site
106370006685	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
106370006686	PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668
106370006687	Protein of unknown function (DUF402); Region: DUF402; pfam04167
106370006688	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
106370006689	Catalytic domain of Protein Kinases; Region: PKc; cd00180
106370006690	active site
106370006691	ATP binding site [chemical binding]; other site
106370006692	substrate binding site [chemical binding]; other site
106370006693	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
106370006694	activation loop (A-loop); other site
106370006695	activation loop (A-loop); other site
106370006696	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
106370006697	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
106370006698	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
106370006699	ATP-binding site [chemical binding]; other site
106370006700	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
106370006701	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
106370006702	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
106370006703	Probable transposase; Region: OrfB_IS605; pfam01385
106370006704	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
106370006705	Probable transposase; Region: OrfB_IS605; pfam01385
106370006706	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
106370006707	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
106370006708	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
106370006709	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
106370006710	DNA binding residues [nucleotide binding]
106370006711	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
106370006712	catalytic residues [active]
106370006713	catalytic nucleophile [active]
106370006714	Transposase IS200 like; Region: Y1_Tnp; pfam01797
106370006715	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
106370006716	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
106370006717	iron-sulfur cluster [ion binding]; other site
106370006718	[2Fe-2S] cluster binding site [ion binding]; other site
106370006719	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
106370006720	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
106370006721	iron-sulfur cluster [ion binding]; other site
106370006722	[2Fe-2S] cluster binding site [ion binding]; other site
106370006723	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
106370006724	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
106370006725	iron-sulfur cluster [ion binding]; other site
106370006726	[2Fe-2S] cluster binding site [ion binding]; other site
106370006727	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
106370006728	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
106370006729	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
106370006730	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
106370006731	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
106370006732	active site
106370006733	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
106370006734	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
106370006735	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
106370006736	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370006737	non-specific DNA binding site [nucleotide binding]; other site
106370006738	salt bridge; other site
106370006739	sequence-specific DNA binding site [nucleotide binding]; other site
106370006740	Domain of unknown function (DUF397); Region: DUF397; pfam04149
106370006741	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
106370006742	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
106370006743	arginine-tRNA ligase; Region: PLN02286
106370006744	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
106370006745	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
106370006746	active site
106370006747	HIGH motif; other site
106370006748	KMSK motif region; other site
106370006749	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
106370006750	tRNA binding surface [nucleotide binding]; other site
106370006751	anticodon binding site; other site
106370006752	conserved hypothetical protein; Region: TIGR03843
106370006753	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
106370006754	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
106370006755	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
106370006756	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
106370006757	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
106370006758	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
106370006759	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370006760	S-adenosylmethionine binding site [chemical binding]; other site
106370006761	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
106370006762	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
106370006763	catalytic residue [active]
106370006764	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
106370006765	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
106370006766	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
106370006767	nucleoside/Zn binding site; other site
106370006768	dimer interface [polypeptide binding]; other site
106370006769	catalytic motif [active]
106370006770	Replication-relaxation; Region: Replic_Relax; pfam13814
106370006771	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
106370006772	dimerization interface [polypeptide binding]; other site
106370006773	putative DNA binding site [nucleotide binding]; other site
106370006774	putative Zn2+ binding site [ion binding]; other site
106370006775	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
106370006776	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
106370006777	catalytic residues [active]
106370006778	catalytic nucleophile [active]
106370006779	Recombinase; Region: Recombinase; pfam07508
106370006780	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
106370006781	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
106370006782	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
106370006783	ATP binding site [chemical binding]; other site
106370006784	putative Mg++ binding site [ion binding]; other site
106370006785	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
106370006786	nucleotide binding region [chemical binding]; other site
106370006787	ATP-binding site [chemical binding]; other site
106370006788	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
106370006789	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
106370006790	putative NAD(P) binding site [chemical binding]; other site
106370006791	Transposase; Region: HTH_Tnp_1; pfam01527
106370006792	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
106370006793	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370006794	non-specific DNA binding site [nucleotide binding]; other site
106370006795	salt bridge; other site
106370006796	sequence-specific DNA binding site [nucleotide binding]; other site
106370006797	HipA N-terminal domain; Region: Couple_hipA; cl11853
106370006798	HipA-like N-terminal domain; Region: HipA_N; pfam07805
106370006799	HipA-like C-terminal domain; Region: HipA_C; pfam07804
106370006800	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
106370006801	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
106370006802	ligand binding site [chemical binding]; other site
106370006803	flexible hinge region; other site
106370006804	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820
106370006805	Putative esterase; Region: Esterase; pfam00756
106370006806	Uncharacterized conserved protein [Function unknown]; Region: COG2898
106370006807	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
106370006808	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
106370006809	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
106370006810	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
106370006811	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
106370006812	P-loop; other site
106370006813	Magnesium ion binding site [ion binding]; other site
106370006814	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
106370006815	Magnesium ion binding site [ion binding]; other site
106370006816	Predicted transcriptional regulators [Transcription]; Region: COG1733
106370006817	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
106370006818	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
106370006819	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
106370006820	active site residue [active]
106370006821	Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141
106370006822	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
106370006823	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
106370006824	substrate binding pocket [chemical binding]; other site
106370006825	active site
106370006826	iron coordination sites [ion binding]; other site
106370006827	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
106370006828	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
106370006829	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
106370006830	Major Facilitator Superfamily; Region: MFS_1; pfam07690
106370006831	putative substrate translocation pore; other site
106370006832	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
106370006833	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
106370006834	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
106370006835	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
106370006836	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
106370006837	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
106370006838	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
106370006839	Ligand Binding Site [chemical binding]; other site
106370006840	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
106370006841	Ligand Binding Site [chemical binding]; other site
106370006842	probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841
106370006843	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
106370006844	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370006845	S-adenosylmethionine binding site [chemical binding]; other site
106370006846	Methyltransferase domain; Region: Methyltransf_31; pfam13847
106370006847	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370006848	S-adenosylmethionine binding site [chemical binding]; other site
106370006849	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
106370006850	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
106370006851	Walker A/P-loop; other site
106370006852	ATP binding site [chemical binding]; other site
106370006853	Q-loop/lid; other site
106370006854	ABC transporter signature motif; other site
106370006855	Walker B; other site
106370006856	D-loop; other site
106370006857	H-loop/switch region; other site
106370006858	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
106370006859	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
106370006860	Walker A/P-loop; other site
106370006861	ATP binding site [chemical binding]; other site
106370006862	Q-loop/lid; other site
106370006863	ABC transporter signature motif; other site
106370006864	Walker B; other site
106370006865	D-loop; other site
106370006866	H-loop/switch region; other site
106370006867	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
106370006868	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
106370006869	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
106370006870	ABC-ATPase subunit interface; other site
106370006871	putative PBP binding loops; other site
106370006872	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
106370006873	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
106370006874	dimer interface [polypeptide binding]; other site
106370006875	conserved gate region; other site
106370006876	putative PBP binding loops; other site
106370006877	ABC-ATPase subunit interface; other site
106370006878	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
106370006879	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492
106370006880	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
106370006881	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
106370006882	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
106370006883	DNA binding residues [nucleotide binding]
106370006884	dimerization interface [polypeptide binding]; other site
106370006885	Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368
106370006886	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
106370006887	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
106370006888	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370006889	sequence-specific DNA binding site [nucleotide binding]; other site
106370006890	salt bridge; other site
106370006891	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
106370006892	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
106370006893	oligomer interface [polypeptide binding]; other site
106370006894	active site residues [active]
106370006895	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
106370006896	Clp protease; Region: CLP_protease; pfam00574
106370006897	oligomer interface [polypeptide binding]; other site
106370006898	active site residues [active]
106370006899	Probable transposase; Region: OrfB_IS605; pfam01385
106370006900	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
106370006901	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
106370006902	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
106370006903	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
106370006904	catalytic residues [active]
106370006905	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
106370006906	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
106370006907	DNA binding residues [nucleotide binding]
106370006908	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
106370006909	DNA binding residues [nucleotide binding]
106370006910	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
106370006911	MerR, DNA binding; Region: MerR-DNA-bind; pfam09278
106370006912	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
106370006913	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
106370006914	dimer interface [polypeptide binding]; other site
106370006915	substrate binding site [chemical binding]; other site
106370006916	metal binding site [ion binding]; metal-binding site
106370006917	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
106370006918	Acetoacetate decarboxylase (ADC); Region: ADC; cl01919
106370006919	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
106370006920	Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099
106370006921	NAD(P) binding site [chemical binding]; other site
106370006922	catalytic residues [active]
106370006923	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
106370006924	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
106370006925	TPP-binding site [chemical binding]; other site
106370006926	tetramer interface [polypeptide binding]; other site
106370006927	heterodimer interface [polypeptide binding]; other site
106370006928	phosphorylation loop region [posttranslational modification]
106370006929	hypothetical protein; Provisional; Region: PRK02237
106370006930	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
106370006931	chaperone-modulator protein CbpM; Provisional; Region: PRK10265
106370006932	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
106370006933	Clp amino terminal domain; Region: Clp_N; pfam02861
106370006934	Clp amino terminal domain; Region: Clp_N; pfam02861
106370006935	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
106370006936	Walker A motif; other site
106370006937	ATP binding site [chemical binding]; other site
106370006938	Walker B motif; other site
106370006939	arginine finger; other site
106370006940	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
106370006941	Walker A motif; other site
106370006942	ATP binding site [chemical binding]; other site
106370006943	Walker B motif; other site
106370006944	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
106370006945	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
106370006946	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
106370006947	HupF/HypC family; Region: HupF_HypC; cl00394
106370006948	CopC domain; Region: CopC; pfam04234
106370006949	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
106370006950	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
106370006951	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
106370006952	Soluble P-type ATPase [General function prediction only]; Region: COG4087
106370006953	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
106370006954	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
106370006955	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
106370006956	Helix-turn-helix domain; Region: HTH_18; pfam12833
106370006957	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
106370006958	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
106370006959	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
106370006960	metabolite-proton symporter; Region: 2A0106; TIGR00883
106370006961	putative substrate translocation pore; other site
106370006962	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
106370006963	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
106370006964	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
106370006965	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
106370006966	pyridoxal 5'-phosphate binding site [chemical binding]; other site
106370006967	homodimer interface [polypeptide binding]; other site
106370006968	catalytic residue [active]
106370006969	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
106370006970	hydrophobic ligand binding site; other site
106370006971	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
106370006972	putative DNA binding site [nucleotide binding]; other site
106370006973	putative Zn2+ binding site [ion binding]; other site
106370006974	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
106370006975	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
106370006976	FAD binding pocket [chemical binding]; other site
106370006977	FAD binding motif [chemical binding]; other site
106370006978	phosphate binding motif [ion binding]; other site
106370006979	NAD binding pocket [chemical binding]; other site
106370006980	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
106370006981	Catalytic domain of Protein Kinases; Region: PKc; cd00180
106370006982	active site
106370006983	ATP binding site [chemical binding]; other site
106370006984	substrate binding site [chemical binding]; other site
106370006985	activation loop (A-loop); other site
106370006986	Tetratricopeptide repeat; Region: TPR_16; pfam13432
106370006987	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
106370006988	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
106370006989	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
106370006990	substrate binding pocket [chemical binding]; other site
106370006991	membrane-bound complex binding site; other site
106370006992	hinge residues; other site
106370006993	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
106370006994	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
106370006995	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
106370006996	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
106370006997	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
106370006998	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
106370006999	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
106370007000	heme binding site [chemical binding]; other site
106370007001	ferroxidase pore; other site
106370007002	ferroxidase diiron center [ion binding]; other site
106370007003	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
106370007004	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
106370007005	delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236
106370007006	NAD(P) binding site [chemical binding]; other site
106370007007	catalytic residues [active]
106370007008	Proline dehydrogenase; Region: Pro_dh; cl03282
106370007009	Protein of unknown function (DUF742); Region: DUF742; pfam05331
106370007010	Roadblock/LC7 domain; Region: Robl_LC7; smart00960
106370007011	Nitrate and nitrite sensing; Region: NIT; pfam08376
106370007012	HAMP domain; Region: HAMP; pfam00672
106370007013	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
106370007014	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
106370007015	Domain of unknown function (DUF222); Region: DUF222; pfam02720
106370007016	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
106370007017	active site
106370007018	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812
106370007019	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
106370007020	homodimer interface [polypeptide binding]; other site
106370007021	substrate-cofactor binding pocket; other site
106370007022	pyridoxal 5'-phosphate binding site [chemical binding]; other site
106370007023	catalytic residue [active]
106370007024	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
106370007025	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
106370007026	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
106370007027	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
106370007028	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
106370007029	putative active site [active]
106370007030	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
106370007031	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
106370007032	Walker A/P-loop; other site
106370007033	ATP binding site [chemical binding]; other site
106370007034	Q-loop/lid; other site
106370007035	ABC transporter signature motif; other site
106370007036	Walker B; other site
106370007037	D-loop; other site
106370007038	H-loop/switch region; other site
106370007039	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
106370007040	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
106370007041	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
106370007042	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
106370007043	active site
106370007044	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
106370007045	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
106370007046	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
106370007047	active site
106370007048	metal binding site [ion binding]; metal-binding site
106370007049	hexamer interface [polypeptide binding]; other site
106370007050	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
106370007051	dimer interface [polypeptide binding]; other site
106370007052	conserved gate region; other site
106370007053	ABC-ATPase subunit interface; other site
106370007054	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
106370007055	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
106370007056	dimer interface [polypeptide binding]; other site
106370007057	conserved gate region; other site
106370007058	putative PBP binding loops; other site
106370007059	ABC-ATPase subunit interface; other site
106370007060	McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737
106370007061	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
106370007062	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
106370007063	Walker A motif; other site
106370007064	ATP binding site [chemical binding]; other site
106370007065	Walker B motif; other site
106370007066	arginine finger; other site
106370007067	Zeta toxin; Region: Zeta_toxin; pfam06414
106370007068	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
106370007069	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
106370007070	ATP binding site [chemical binding]; other site
106370007071	diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830
106370007072	active site
106370007073	ADP/pyrophosphate binding site [chemical binding]; other site
106370007074	allosteric effector site; other site
106370007075	dimerization interface [polypeptide binding]; other site
106370007076	fructose-1,6-bisphosphate binding site; other site
106370007077	Part of AAA domain; Region: AAA_19; pfam13245
106370007078	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
106370007079	AAA domain; Region: AAA_12; pfam13087
106370007080	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
106370007081	putative active site [active]
106370007082	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
106370007083	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
106370007084	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
106370007085	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
106370007086	NAD(P) binding site [chemical binding]; other site
106370007087	active site
106370007088	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
106370007089	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
106370007090	active site
106370007091	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
106370007092	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
106370007093	dimer interface [polypeptide binding]; other site
106370007094	active site
106370007095	Cupin domain; Region: Cupin_2; pfam07883
106370007096	N-terminal aromatase/cyclase domain of the multifunctional protein tetracenomycin (TcmN) and related domains; Region: TcmN_ARO-CYC_like; cd08860
106370007097	putative hydrophobic ligand binding site [chemical binding]; other site
106370007098	active site
106370007099	catalytic residues_2 [active]
106370007100	catalytic residues_1 [active]
106370007101	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
106370007102	Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673
106370007103	Predicted transcriptional regulators [Transcription]; Region: COG1378
106370007104	DNA binding residues [nucleotide binding]
106370007105	dimerization interface [polypeptide binding]; other site
106370007106	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
106370007107	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
106370007108	G2 box; other site
106370007109	Switch I region; other site
106370007110	G3 box; other site
106370007111	Switch II region; other site
106370007112	GTP/Mg2+ binding site [chemical binding]; other site
106370007113	G4 box; other site
106370007114	G5 box; other site
106370007115	Protein of unknown function (DUF742); Region: DUF742; pfam05331
106370007116	Roadblock/LC7 domain; Region: Robl_LC7; smart00960
106370007117	Nitrate and nitrite sensing; Region: NIT; pfam08376
106370007118	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
106370007119	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
106370007120	ATP binding site [chemical binding]; other site
106370007121	Mg2+ binding site [ion binding]; other site
106370007122	G-X-G motif; other site
106370007123	enoyl-CoA hydratase; Provisional; Region: PRK06688
106370007124	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
106370007125	substrate binding site [chemical binding]; other site
106370007126	oxyanion hole (OAH) forming residues; other site
106370007127	trimer interface [polypeptide binding]; other site
106370007128	Protein of unknown function (DUF445); Region: DUF445; pfam04286
106370007129	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
106370007130	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
106370007131	putative Mg++ binding site [ion binding]; other site
106370007132	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
106370007133	nucleotide binding region [chemical binding]; other site
106370007134	ATP-binding site [chemical binding]; other site
106370007135	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
106370007136	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
106370007137	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
106370007138	catalytic residue [active]
106370007139	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
106370007140	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
106370007141	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
106370007142	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370007143	S-adenosylmethionine binding site [chemical binding]; other site
106370007144	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
106370007145	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
106370007146	putative substrate translocation pore; other site
106370007147	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
106370007148	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
106370007149	NAD(P) binding site [chemical binding]; other site
106370007150	catalytic residues [active]
106370007151	L-lysine aminotransferase; Provisional; Region: PRK08297
106370007152	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
106370007153	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
106370007154	catalytic residue [active]
106370007155	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
106370007156	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
106370007157	active site
106370007158	ATP binding site [chemical binding]; other site
106370007159	substrate binding site [chemical binding]; other site
106370007160	activation loop (A-loop); other site
106370007161	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
106370007162	Protein kinase domain; Region: Pkinase; pfam00069
106370007163	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
106370007164	active site
106370007165	ATP binding site [chemical binding]; other site
106370007166	substrate binding site [chemical binding]; other site
106370007167	activation loop (A-loop); other site
106370007168	Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080
106370007169	PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874
106370007170	putative active site [active]
106370007171	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
106370007172	putative FMN binding site [chemical binding]; other site
106370007173	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
106370007174	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
106370007175	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370007176	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
106370007177	non-specific DNA binding site [nucleotide binding]; other site
106370007178	salt bridge; other site
106370007179	sequence-specific DNA binding site [nucleotide binding]; other site
106370007180	DDE superfamily endonuclease; Region: DDE_3; pfam13358
106370007181	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
106370007182	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
106370007183	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
106370007184	nudix motif; other site
106370007185	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
106370007186	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
106370007187	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
106370007188	motif II; other site
106370007189	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
106370007190	TPR motif; other site
106370007191	binding surface
106370007192	Resolvase, N terminal domain; Region: Resolvase; smart00857
106370007193	catalytic residues [active]
106370007194	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
106370007195	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
106370007196	ATP binding site [chemical binding]; other site
106370007197	Mg2+ binding site [ion binding]; other site
106370007198	G-X-G motif; other site
106370007199	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
106370007200	B12 binding domain; Region: B12-binding; pfam02310
106370007201	B12 binding site [chemical binding]; other site
106370007202	Radical SAM superfamily; Region: Radical_SAM; pfam04055
106370007203	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
106370007204	FeS/SAM binding site; other site
106370007205	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
106370007206	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
106370007207	hypothetical protein; Provisional; Region: PRK06185
106370007208	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
106370007209	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
106370007210	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
106370007211	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
106370007212	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
106370007213	putative metal binding site [ion binding]; other site
106370007214	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
106370007215	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
106370007216	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
106370007217	active site
106370007218	catalytic tetrad [active]
106370007219	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
106370007220	active site
106370007221	SpoOM protein; Region: Spo0M; pfam07070
106370007222	Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326
106370007223	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
106370007224	Coenzyme A binding pocket [chemical binding]; other site
106370007225	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
106370007226	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
106370007227	asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104
106370007228	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
106370007229	active site
106370007230	dimer interface [polypeptide binding]; other site
106370007231	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
106370007232	Ligand Binding Site [chemical binding]; other site
106370007233	Molecular Tunnel; other site
106370007234	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
106370007235	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
106370007236	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
106370007237	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
106370007238	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
106370007239	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
106370007240	active site
106370007241	FMN binding site [chemical binding]; other site
106370007242	substrate binding site [chemical binding]; other site
106370007243	3Fe-4S cluster binding site [ion binding]; other site
106370007244	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
106370007245	dimer interface [polypeptide binding]; other site
106370007246	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
106370007247	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
106370007248	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
106370007249	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
106370007250	metal ion-dependent adhesion site (MIDAS); other site
106370007251	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
106370007252	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
106370007253	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
106370007254	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
106370007255	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
106370007256	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
106370007257	putative active site [active]
106370007258	putative catalytic site [active]
106370007259	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
106370007260	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
106370007261	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
106370007262	ATP-grasp domain; Region: ATP-grasp_4; cl17255
106370007263	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
106370007264	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
106370007265	carboxyltransferase (CT) interaction site; other site
106370007266	biotinylation site [posttranslational modification]; other site
106370007267	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
106370007268	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
106370007269	2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase  FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742
106370007270	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
106370007271	FMN binding site [chemical binding]; other site
106370007272	substrate binding site [chemical binding]; other site
106370007273	putative catalytic residue [active]
106370007274	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
106370007275	active site 1 [active]
106370007276	dimer interface [polypeptide binding]; other site
106370007277	active site 2 [active]
106370007278	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
106370007279	3-oxoacyl-acyl carrier protein synthase; Provisional; Region: PTZ00050
106370007280	active site
106370007281	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
106370007282	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
106370007283	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
106370007284	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
106370007285	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
106370007286	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
106370007287	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
106370007288	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
106370007289	putative NADP binding site [chemical binding]; other site
106370007290	active site
106370007291	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
106370007292	active site
106370007293	catalytic triad [active]
106370007294	oxyanion hole [active]
106370007295	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
106370007296	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
106370007297	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
106370007298	CoenzymeA binding site [chemical binding]; other site
106370007299	subunit interaction site [polypeptide binding]; other site
106370007300	PHB binding site; other site
106370007301	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
106370007302	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
106370007303	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
106370007304	Domain of unknown function (DUF1772); Region: DUF1772; pfam08592
106370007305	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
106370007306	TrkA-N domain; Region: TrkA_N; pfam02254
106370007307	Ion channel; Region: Ion_trans_2; pfam07885
106370007308	TrkA-N domain; Region: TrkA_N; pfam02254
106370007309	Uncharacterized conserved protein [Function unknown]; Region: COG1479
106370007310	Protein of unknown function DUF262; Region: DUF262; pfam03235
106370007311	Protein of unknown function DUF262; Region: DUF262; pfam03235
106370007312	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
106370007313	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
106370007314	active site
106370007315	DNA binding site [nucleotide binding]
106370007316	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
106370007317	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
106370007318	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
106370007319	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
106370007320	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
106370007321	NAD(P) binding site [chemical binding]; other site
106370007322	catalytic residues [active]
106370007323	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
106370007324	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
106370007325	NAD binding site [chemical binding]; other site
106370007326	substrate binding site [chemical binding]; other site
106370007327	catalytic Zn binding site [ion binding]; other site
106370007328	tetramer interface [polypeptide binding]; other site
106370007329	structural Zn binding site [ion binding]; other site
106370007330	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
106370007331	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
106370007332	ligand binding site [chemical binding]; other site
106370007333	homodimer interface [polypeptide binding]; other site
106370007334	NAD(P) binding site [chemical binding]; other site
106370007335	trimer interface B [polypeptide binding]; other site
106370007336	trimer interface A [polypeptide binding]; other site
106370007337	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
106370007338	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
106370007339	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
106370007340	hydroperoxidase II; Provisional; Region: katE; PRK11249
106370007341	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
106370007342	heme binding pocket [chemical binding]; other site
106370007343	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
106370007344	domain interactions; other site
106370007345	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
106370007346	CoA binding domain; Region: CoA_binding_2; pfam13380
106370007347	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
106370007348	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
106370007349	prephenate dehydratase; Provisional; Region: PRK11899
106370007350	Prephenate dehydratase; Region: PDT; pfam00800
106370007351	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
106370007352	putative L-Phe binding site [chemical binding]; other site
106370007353	Nuclease-related domain; Region: NERD; pfam08378
106370007354	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
106370007355	active site
106370007356	ATP binding site [chemical binding]; other site
106370007357	substrate binding site [chemical binding]; other site
106370007358	activation loop (A-loop); other site
106370007359	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
106370007360	Catalytic domain of Protein Kinases; Region: PKc; cd00180
106370007361	active site
106370007362	ATP binding site [chemical binding]; other site
106370007363	substrate binding site [chemical binding]; other site
106370007364	activation loop (A-loop); other site
106370007365	Methyltransferase domain; Region: Methyltransf_26; pfam13659
106370007366	PglZ domain; Region: PglZ; pfam08665
106370007367	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
106370007368	Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201
106370007369	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
106370007370	ATP binding site [chemical binding]; other site
106370007371	putative Mg++ binding site [ion binding]; other site
106370007372	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
106370007373	nucleotide binding region [chemical binding]; other site
106370007374	PemK-like protein; Region: PemK; cl00995
106370007375	HicB family; Region: HicB; pfam05534
106370007376	Pirin-related protein [General function prediction only]; Region: COG1741
106370007377	Pirin; Region: Pirin; pfam02678
106370007378	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
106370007379	DNA binding site [nucleotide binding]
106370007380	active site
106370007381	Int/Topo IB signature motif; other site
106370007382	catalytic residues [active]
106370007383	Transposase IS200 like; Region: Y1_Tnp; pfam01797
106370007384	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
106370007385	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
106370007386	Probable transposase; Region: OrfB_IS605; pfam01385
106370007387	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
106370007388	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
106370007389	Cupin domain; Region: Cupin_2; pfam07883
106370007390	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
106370007391	Transposase; Region: DEDD_Tnp_IS110; pfam01548
106370007392	Transcriptional regulators [Transcription]; Region: MarR; COG1846
106370007393	MarR family; Region: MarR_2; pfam12802
106370007394	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
106370007395	putative active site [active]
106370007396	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
106370007397	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
106370007398	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
106370007399	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
106370007400	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
106370007401	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
106370007402	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
106370007403	NodB motif; other site
106370007404	active site
106370007405	metal binding site [ion binding]; metal-binding site
106370007406	Transcriptional regulators [Transcription]; Region: FadR; COG2186
106370007407	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
106370007408	DNA-binding site [nucleotide binding]; DNA binding site
106370007409	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
106370007410	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
106370007411	active site
106370007412	putative homodimer interface [polypeptide binding]; other site
106370007413	SAM binding site [chemical binding]; other site
106370007414	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
106370007415	precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469
106370007416	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
106370007417	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
106370007418	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
106370007419	active site
106370007420	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
106370007421	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
106370007422	ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952
106370007423	NADP binding site [chemical binding]; other site
106370007424	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
106370007425	active site
106370007426	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
106370007427	Thioesterase; Region: PKS_TE; smart00824
106370007428	acyl-CoA synthetase; Validated; Region: PRK07787
106370007429	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
106370007430	acyl-activating enzyme (AAE) consensus motif; other site
106370007431	AMP binding site [chemical binding]; other site
106370007432	active site
106370007433	CoA binding site [chemical binding]; other site
106370007434	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
106370007435	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
106370007436	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
106370007437	Walker A/P-loop; other site
106370007438	ATP binding site [chemical binding]; other site
106370007439	Q-loop/lid; other site
106370007440	ABC transporter signature motif; other site
106370007441	Walker B; other site
106370007442	D-loop; other site
106370007443	H-loop/switch region; other site
106370007444	Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471
106370007445	PqqD family protein, HPr-rel-A system; Region: PqqD_rel_X; TIGR04353
106370007446	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
106370007447	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
106370007448	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
106370007449	N-acetyl-D-glucosamine binding site [chemical binding]; other site
106370007450	catalytic residue [active]
106370007451	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
106370007452	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
106370007453	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
106370007454	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
106370007455	dimerization interface [polypeptide binding]; other site
106370007456	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
106370007457	active site
106370007458	S-adenosylmethionine synthetase; Validated; Region: PRK05250
106370007459	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
106370007460	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
106370007461	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
106370007462	Domain of unknown function (DUF309); Region: DUF309; pfam03745
106370007463	TIR domain; Region: TIR_2; pfam13676
106370007464	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
106370007465	acetyl-CoA acetyltransferase; Provisional; Region: PRK06504
106370007466	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
106370007467	dimer interface [polypeptide binding]; other site
106370007468	active site
106370007469	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
106370007470	Domain of unknown function DUF21; Region: DUF21; pfam01595
106370007471	FOG: CBS domain [General function prediction only]; Region: COG0517
106370007472	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
106370007473	Transporter associated domain; Region: CorC_HlyC; smart01091
106370007474	Domain of unknown function DUF21; Region: DUF21; pfam01595
106370007475	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
106370007476	FOG: CBS domain [General function prediction only]; Region: COG0517
106370007477	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370007478	S-adenosylmethionine binding site [chemical binding]; other site
106370007479	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
106370007480	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
106370007481	active site
106370007482	ATP binding site [chemical binding]; other site
106370007483	substrate binding site [chemical binding]; other site
106370007484	activation loop (A-loop); other site
106370007485	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
106370007486	structural tetrad; other site
106370007487	FOG: WD40 repeat [General function prediction only]; Region: COG2319
106370007488	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
106370007489	nucleotide binding site [chemical binding]; other site
106370007490	putative NEF/HSP70 interaction site [polypeptide binding]; other site
106370007491	SBD interface [polypeptide binding]; other site
106370007492	PBP superfamily domain; Region: PBP_like_2; cl17296
106370007493	membrane ATPase/protein kinase; Provisional; Region: PRK09435
106370007494	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
106370007495	Walker A; other site
106370007496	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
106370007497	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
106370007498	active site
106370007499	substrate binding site [chemical binding]; other site
106370007500	coenzyme B12 binding site [chemical binding]; other site
106370007501	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
106370007502	B12 binding site [chemical binding]; other site
106370007503	cobalt ligand [ion binding]; other site
106370007504	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
106370007505	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
106370007506	heterodimer interface [polypeptide binding]; other site
106370007507	substrate interaction site [chemical binding]; other site
106370007508	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
106370007509	Predicted permeases [General function prediction only]; Region: COG0730
106370007510	tellurite resistance protein terB; Region: terB; cd07176
106370007511	putative metal binding site [ion binding]; other site
106370007512	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
106370007513	active site
106370007514	catalytic site [active]
106370007515	adenylate kinase; Reviewed; Region: adk; PRK00279
106370007516	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
106370007517	AMP-binding site [chemical binding]; other site
106370007518	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
106370007519	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
106370007520	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
106370007521	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
106370007522	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
106370007523	active site
106370007524	dimer interface [polypeptide binding]; other site
106370007525	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
106370007526	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
106370007527	active site
106370007528	FMN binding site [chemical binding]; other site
106370007529	substrate binding site [chemical binding]; other site
106370007530	3Fe-4S cluster binding site [ion binding]; other site
106370007531	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
106370007532	domain interface; other site
106370007533	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
106370007534	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
106370007535	substrate binding site [chemical binding]; other site
106370007536	active site
106370007537	catalytic residues [active]
106370007538	heterodimer interface [polypeptide binding]; other site
106370007539	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
106370007540	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
106370007541	pyridoxal 5'-phosphate binding site [chemical binding]; other site
106370007542	catalytic residue [active]
106370007543	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
106370007544	active site
106370007545	ribulose/triose binding site [chemical binding]; other site
106370007546	phosphate binding site [ion binding]; other site
106370007547	substrate (anthranilate) binding pocket [chemical binding]; other site
106370007548	product (indole) binding pocket [chemical binding]; other site
106370007549	Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534
106370007550	anthranilate synthase component I; Provisional; Region: PRK13571
106370007551	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
106370007552	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
106370007553	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
106370007554	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
106370007555	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
106370007556	substrate binding site [chemical binding]; other site
106370007557	glutamase interaction surface [polypeptide binding]; other site
106370007558	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
106370007559	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
106370007560	catalytic residues [active]
106370007561	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
106370007562	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
106370007563	putative active site [active]
106370007564	oxyanion strand; other site
106370007565	catalytic triad [active]
106370007566	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
106370007567	putative active site pocket [active]
106370007568	4-fold oligomerization interface [polypeptide binding]; other site
106370007569	metal binding residues [ion binding]; metal-binding site
106370007570	3-fold/trimer interface [polypeptide binding]; other site
106370007571	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
106370007572	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
106370007573	pyridoxal 5'-phosphate binding site [chemical binding]; other site
106370007574	homodimer interface [polypeptide binding]; other site
106370007575	catalytic residue [active]
106370007576	histidinol dehydrogenase; Region: hisD; TIGR00069
106370007577	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
106370007578	NAD binding site [chemical binding]; other site
106370007579	dimerization interface [polypeptide binding]; other site
106370007580	product binding site; other site
106370007581	substrate binding site [chemical binding]; other site
106370007582	zinc binding site [ion binding]; other site
106370007583	catalytic residues [active]
106370007584	Protein of unknown function DUF43; Region: DUF43; pfam01861
106370007585	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
106370007586	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
106370007587	active site
106370007588	phosphorylation site [posttranslational modification]
106370007589	intermolecular recognition site; other site
106370007590	dimerization interface [polypeptide binding]; other site
106370007591	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
106370007592	DNA binding site [nucleotide binding]
106370007593	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
106370007594	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
106370007595	dimerization interface [polypeptide binding]; other site
106370007596	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
106370007597	dimer interface [polypeptide binding]; other site
106370007598	phosphorylation site [posttranslational modification]
106370007599	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
106370007600	ATP binding site [chemical binding]; other site
106370007601	Mg2+ binding site [ion binding]; other site
106370007602	G-X-G motif; other site
106370007603	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
106370007604	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
106370007605	Transcriptional regulator; Region: Rrf2; cl17282
106370007606	Rrf2 family protein; Region: rrf2_super; TIGR00738
106370007607	4Fe-4S binding domain; Region: Fer4; pfam00037
106370007608	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
106370007609	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
106370007610	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
106370007611	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
106370007612	putative active site [active]
106370007613	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
106370007614	AAA ATPase domain; Region: AAA_16; pfam13191
106370007615	AAA domain; Region: AAA_22; pfam13401
106370007616	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
106370007617	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
106370007618	DNA binding residues [nucleotide binding]
106370007619	dimerization interface [polypeptide binding]; other site
106370007620	Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876
106370007621	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
106370007622	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
106370007623	MarR family; Region: MarR_2; pfam12802
106370007624	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
106370007625	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
106370007626	active site
106370007627	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
106370007628	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
106370007629	FeS/SAM binding site; other site
106370007630	Domain of unknown function (DUF397); Region: DUF397; pfam04149
106370007631	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
106370007632	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
106370007633	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
106370007634	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
106370007635	dimer interface [polypeptide binding]; other site
106370007636	catalytic triad [active]
106370007637	Domain of unknown function (DUF4234); Region: DUF4234; pfam14018
106370007638	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
106370007639	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
106370007640	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
106370007641	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
106370007642	dimer interface [polypeptide binding]; other site
106370007643	TPP-binding site [chemical binding]; other site
106370007644	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
106370007645	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
106370007646	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
106370007647	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
106370007648	Ligand binding site; other site
106370007649	Putative Catalytic site; other site
106370007650	DXD motif; other site
106370007651	CoA binding domain; Region: CoA_binding; cl17356
106370007652	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
106370007653	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
106370007654	putative metal binding site [ion binding]; other site
106370007655	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
106370007656	lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
106370007657	lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
106370007658	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
106370007659	thiamine phosphate binding site [chemical binding]; other site
106370007660	active site
106370007661	pyrophosphate binding site [ion binding]; other site
106370007662	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
106370007663	thiS-thiF/thiG interaction site; other site
106370007664	Helix-turn-helix domain; Region: HTH_17; cl17695
106370007665	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
106370007666	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
106370007667	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
106370007668	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
106370007669	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
106370007670	FeS/SAM binding site; other site
106370007671	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
106370007672	thiazole synthase; Reviewed; Region: thiG; PRK00208
106370007673	phosphate binding site [ion binding]; other site
106370007674	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
106370007675	Catalytic domain of Protein Kinases; Region: PKc; cd00180
106370007676	active site
106370007677	ATP binding site [chemical binding]; other site
106370007678	substrate binding site [chemical binding]; other site
106370007679	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
106370007680	substrate binding site [chemical binding]; other site
106370007681	activation loop (A-loop); other site
106370007682	activation loop (A-loop); other site
106370007683	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
106370007684	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
106370007685	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
106370007686	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
106370007687	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
106370007688	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
106370007689	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370007690	non-specific DNA binding site [nucleotide binding]; other site
106370007691	salt bridge; other site
106370007692	sequence-specific DNA binding site [nucleotide binding]; other site
106370007693	hypothetical protein; Provisional; Region: PRK09266
106370007694	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
106370007695	substrate-cofactor binding pocket; other site
106370007696	homodimer interface [polypeptide binding]; other site
106370007697	pyridoxal 5'-phosphate binding site [chemical binding]; other site
106370007698	catalytic residue [active]
106370007699	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
106370007700	phosphofructokinase; Region: PFK_mixed; TIGR02483
106370007701	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
106370007702	active site
106370007703	ADP/pyrophosphate binding site [chemical binding]; other site
106370007704	dimerization interface [polypeptide binding]; other site
106370007705	allosteric effector site; other site
106370007706	fructose-1,6-bisphosphate binding site; other site
106370007707	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
106370007708	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
106370007709	putative acyl-acceptor binding pocket; other site
106370007710	Esterase/lipase [General function prediction only]; Region: COG1647
106370007711	Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144
106370007712	Uncharacterized conserved protein [Function unknown]; Region: COG1915
106370007713	homodimer interface [polypeptide binding]; other site
106370007714	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
106370007715	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
106370007716	nucleotide binding site [chemical binding]; other site
106370007717	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
106370007718	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
106370007719	DTAP/Switch II; other site
106370007720	Switch I; other site
106370007721	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
106370007722	putative hydrophobic ligand binding site [chemical binding]; other site
106370007723	Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129
106370007724	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
106370007725	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
106370007726	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
106370007727	acyl-activating enzyme (AAE) consensus motif; other site
106370007728	putative AMP binding site [chemical binding]; other site
106370007729	putative active site [active]
106370007730	putative CoA binding site [chemical binding]; other site
106370007731	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
106370007732	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
106370007733	YacP-like NYN domain; Region: NYN_YacP; cl01491
106370007734	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
106370007735	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
106370007736	nucleotide binding site/active site [active]
106370007737	HIT family signature motif; other site
106370007738	catalytic residue [active]
106370007739	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
106370007740	active site
106370007741	hypothetical protein; Validated; Region: PRK07883
106370007742	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
106370007743	active site
106370007744	catalytic site [active]
106370007745	substrate binding site [chemical binding]; other site
106370007746	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
106370007747	GIY-YIG motif/motif A; other site
106370007748	active site
106370007749	catalytic site [active]
106370007750	putative DNA binding site [nucleotide binding]; other site
106370007751	metal binding site [ion binding]; metal-binding site
106370007752	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
106370007753	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
106370007754	heme bH binding site [chemical binding]; other site
106370007755	intrachain domain interface; other site
106370007756	Qi binding site; other site
106370007757	heme bL binding site [chemical binding]; other site
106370007758	interchain domain interface [polypeptide binding]; other site
106370007759	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
106370007760	Qo binding site; other site
106370007761	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
106370007762	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
106370007763	iron-sulfur cluster [ion binding]; other site
106370007764	[2Fe-2S] cluster binding site [ion binding]; other site
106370007765	Cytochrome c; Region: Cytochrom_C; pfam00034
106370007766	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
106370007767	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
106370007768	Subunit I/III interface [polypeptide binding]; other site
106370007769	Protein of unknown function (DUF3501); Region: DUF3501; pfam12007
106370007770	Rubrerythrin [Energy production and conversion]; Region: COG1592
106370007771	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
106370007772	binuclear metal center [ion binding]; other site
106370007773	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
106370007774	metal binding site 2 [ion binding]; metal-binding site
106370007775	putative DNA binding helix; other site
106370007776	metal binding site 1 [ion binding]; metal-binding site
106370007777	dimer interface [polypeptide binding]; other site
106370007778	structural Zn2+ binding site [ion binding]; other site
106370007779	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
106370007780	active site
106370007781	phosphorylation site [posttranslational modification]
106370007782	intermolecular recognition site; other site
106370007783	dimerization interface [polypeptide binding]; other site
106370007784	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
106370007785	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
106370007786	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
106370007787	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
106370007788	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
106370007789	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
106370007790	D-pathway; other site
106370007791	Putative ubiquinol binding site [chemical binding]; other site
106370007792	Low-spin heme (heme b) binding site [chemical binding]; other site
106370007793	Putative water exit pathway; other site
106370007794	Binuclear center (heme o3/CuB) [ion binding]; other site
106370007795	K-pathway; other site
106370007796	Putative proton exit pathway; other site
106370007797	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
106370007798	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
106370007799	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
106370007800	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
106370007801	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
106370007802	catalytic residue [active]
106370007803	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
106370007804	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
106370007805	substrate binding site [chemical binding]; other site
106370007806	ATP binding site [chemical binding]; other site
106370007807	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
106370007808	quinolinate synthetase; Provisional; Region: PRK09375
106370007809	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
106370007810	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
106370007811	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
106370007812	active site
106370007813	catalytic tetrad [active]
106370007814	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
106370007815	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
106370007816	WHG domain; Region: WHG; pfam13305
106370007817	Domain of unknown function (DUF385); Region: DUF385; cl04387
106370007818	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
106370007819	Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; pfam02283
106370007820	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
106370007821	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
106370007822	putative dimer interface [polypeptide binding]; other site
106370007823	active site pocket [active]
106370007824	putative cataytic base [active]
106370007825	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
106370007826	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
106370007827	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
106370007828	multifunctional aminopeptidase A; Provisional; Region: PRK00913
106370007829	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
106370007830	interface (dimer of trimers) [polypeptide binding]; other site
106370007831	Substrate-binding/catalytic site; other site
106370007832	Zn-binding sites [ion binding]; other site
106370007833	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
106370007834	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
106370007835	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
106370007836	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
106370007837	E3 interaction surface; other site
106370007838	lipoyl attachment site [posttranslational modification]; other site
106370007839	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
106370007840	e3 binding domain; Region: E3_binding; pfam02817
106370007841	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
106370007842	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
106370007843	active site pocket [active]
106370007844	oxyanion hole [active]
106370007845	catalytic triad [active]
106370007846	active site nucleophile [active]
106370007847	lipoyl synthase; Provisional; Region: PRK05481
106370007848	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
106370007849	FeS/SAM binding site; other site
106370007850	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
106370007851	RDD family; Region: RDD; pfam06271
106370007852	glutamine synthetase, type I; Region: GlnA; TIGR00653
106370007853	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
106370007854	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
106370007855	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
106370007856	glutamine synthetase; Region: PLN02284
106370007857	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
106370007858	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
106370007859	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
106370007860	metal binding triad; other site
106370007861	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
106370007862	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
106370007863	metal binding triad; other site
106370007864	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
106370007865	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
106370007866	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
106370007867	NAD synthetase; Provisional; Region: PRK13981
106370007868	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
106370007869	multimer interface [polypeptide binding]; other site
106370007870	active site
106370007871	catalytic triad [active]
106370007872	protein interface 1 [polypeptide binding]; other site
106370007873	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
106370007874	homodimer interface [polypeptide binding]; other site
106370007875	NAD binding pocket [chemical binding]; other site
106370007876	ATP binding pocket [chemical binding]; other site
106370007877	Mg binding site [ion binding]; other site
106370007878	active-site loop [active]
106370007879	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
106370007880	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
106370007881	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
106370007882	active site
106370007883	dimer interface [polypeptide binding]; other site
106370007884	motif 1; other site
106370007885	motif 2; other site
106370007886	motif 3; other site
106370007887	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
106370007888	anticodon binding site; other site
106370007889	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
106370007890	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
106370007891	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
106370007892	oligomerization interface [polypeptide binding]; other site
106370007893	active site
106370007894	metal binding site [ion binding]; metal-binding site
106370007895	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
106370007896	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
106370007897	intersubunit interface [polypeptide binding]; other site
106370007898	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
106370007899	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
106370007900	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
106370007901	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
106370007902	active site
106370007903	DNA binding site [nucleotide binding]
106370007904	Int/Topo IB signature motif; other site
106370007905	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
106370007906	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
106370007907	dimer interface [polypeptide binding]; other site
106370007908	active site
106370007909	ADP-ribose binding site [chemical binding]; other site
106370007910	nudix motif; other site
106370007911	metal binding site [ion binding]; metal-binding site
106370007912	CTP synthetase; Validated; Region: pyrG; PRK05380
106370007913	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
106370007914	Catalytic site [active]
106370007915	active site
106370007916	UTP binding site [chemical binding]; other site
106370007917	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
106370007918	active site
106370007919	putative oxyanion hole; other site
106370007920	catalytic triad [active]
106370007921	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
106370007922	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
106370007923	Walker A/P-loop; other site
106370007924	ATP binding site [chemical binding]; other site
106370007925	Q-loop/lid; other site
106370007926	ABC transporter signature motif; other site
106370007927	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
106370007928	ABC transporter signature motif; other site
106370007929	Walker B; other site
106370007930	D-loop; other site
106370007931	H-loop/switch region; other site
106370007932	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372
106370007933	ATP-NAD kinase; Region: NAD_kinase; pfam01513
106370007934	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
106370007935	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
106370007936	RNA binding surface [nucleotide binding]; other site
106370007937	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370007938	S-adenosylmethionine binding site [chemical binding]; other site
106370007939	SCP-2 sterol transfer family; Region: SCP2; pfam02036
106370007940	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
106370007941	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
106370007942	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
106370007943	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
106370007944	binding surface
106370007945	TPR motif; other site
106370007946	Tetratricopeptide repeat; Region: TPR_16; pfam13432
106370007947	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
106370007948	Uncharacterized conserved protein [Function unknown]; Region: COG4198
106370007949	Uncharacterized conserved protein [Function unknown]; Region: COG4198
106370007950	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
106370007951	active site
106370007952	DNA binding site [nucleotide binding]
106370007953	argininosuccinate lyase; Provisional; Region: PRK00855
106370007954	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
106370007955	active sites [active]
106370007956	tetramer interface [polypeptide binding]; other site
106370007957	argininosuccinate synthase; Provisional; Region: PRK13820
106370007958	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
106370007959	ANP binding site [chemical binding]; other site
106370007960	Substrate Binding Site II [chemical binding]; other site
106370007961	Substrate Binding Site I [chemical binding]; other site
106370007962	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
106370007963	Arginine repressor [Transcription]; Region: ArgR; COG1438
106370007964	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
106370007965	ornithine carbamoyltransferase; Provisional; Region: PRK00779
106370007966	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
106370007967	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
106370007968	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
106370007969	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
106370007970	inhibitor-cofactor binding pocket; inhibition site
106370007971	pyridoxal 5'-phosphate binding site [chemical binding]; other site
106370007972	catalytic residue [active]
106370007973	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
106370007974	feedback inhibition sensing region; other site
106370007975	homohexameric interface [polypeptide binding]; other site
106370007976	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
106370007977	nucleotide binding site [chemical binding]; other site
106370007978	N-acetyl-L-glutamate binding site [chemical binding]; other site
106370007979	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
106370007980	heterotetramer interface [polypeptide binding]; other site
106370007981	active site pocket [active]
106370007982	cleavage site
106370007983	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
106370007984	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
106370007985	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
106370007986	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
106370007987	putative tRNA-binding site [nucleotide binding]; other site
106370007988	B3/4 domain; Region: B3_4; pfam03483
106370007989	tRNA synthetase B5 domain; Region: B5; smart00874
106370007990	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
106370007991	dimer interface [polypeptide binding]; other site
106370007992	motif 1; other site
106370007993	motif 3; other site
106370007994	motif 2; other site
106370007995	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
106370007996	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
106370007997	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
106370007998	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
106370007999	dimer interface [polypeptide binding]; other site
106370008000	motif 1; other site
106370008001	active site
106370008002	motif 2; other site
106370008003	motif 3; other site
106370008004	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
106370008005	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
106370008006	putative active site [active]
106370008007	heme pocket [chemical binding]; other site
106370008008	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
106370008009	dimer interface [polypeptide binding]; other site
106370008010	phosphorylation site [posttranslational modification]
106370008011	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
106370008012	ATP binding site [chemical binding]; other site
106370008013	Mg2+ binding site [ion binding]; other site
106370008014	G-X-G motif; other site
106370008015	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
106370008016	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
106370008017	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
106370008018	23S rRNA binding site [nucleotide binding]; other site
106370008019	L21 binding site [polypeptide binding]; other site
106370008020	L13 binding site [polypeptide binding]; other site
106370008021	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
106370008022	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
106370008023	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
106370008024	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
106370008025	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
106370008026	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
106370008027	homopentamer interface [polypeptide binding]; other site
106370008028	active site
106370008029	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
106370008030	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
106370008031	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
106370008032	dimerization interface [polypeptide binding]; other site
106370008033	active site
106370008034	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
106370008035	Lumazine binding domain; Region: Lum_binding; pfam00677
106370008036	Lumazine binding domain; Region: Lum_binding; pfam00677
106370008037	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
106370008038	substrate binding site [chemical binding]; other site
106370008039	hexamer interface [polypeptide binding]; other site
106370008040	metal binding site [ion binding]; metal-binding site
106370008041	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
106370008042	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
106370008043	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
106370008044	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
106370008045	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
106370008046	putative active site [active]
106370008047	substrate binding site [chemical binding]; other site
106370008048	putative cosubstrate binding site; other site
106370008049	catalytic site [active]
106370008050	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
106370008051	substrate binding site [chemical binding]; other site
106370008052	primosome assembly protein PriA; Provisional; Region: PRK14873
106370008053	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
106370008054	S-adenosylmethionine synthetase; Validated; Region: PRK05250
106370008055	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
106370008056	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
106370008057	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
106370008058	Flavoprotein; Region: Flavoprotein; pfam02441
106370008059	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
106370008060	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
106370008061	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
106370008062	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
106370008063	catalytic site [active]
106370008064	G-X2-G-X-G-K; other site
106370008065	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
106370008066	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
106370008067	active site
106370008068	dimer interface [polypeptide binding]; other site
106370008069	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
106370008070	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
106370008071	ATP-grasp domain; Region: ATP-grasp_4; cl17255
106370008072	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
106370008073	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
106370008074	ATP-grasp domain; Region: ATP-grasp_4; cl17255
106370008075	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
106370008076	IMP binding site; other site
106370008077	dimer interface [polypeptide binding]; other site
106370008078	interdomain contacts; other site
106370008079	partial ornithine binding site; other site
106370008080	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
106370008081	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
106370008082	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
106370008083	catalytic site [active]
106370008084	subunit interface [polypeptide binding]; other site
106370008085	dihydroorotase; Validated; Region: pyrC; PRK09357
106370008086	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
106370008087	active site
106370008088	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
106370008089	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
106370008090	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
106370008091	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
106370008092	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
106370008093	active site
106370008094	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
106370008095	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370008096	non-specific DNA binding site [nucleotide binding]; other site
106370008097	salt bridge; other site
106370008098	sequence-specific DNA binding site [nucleotide binding]; other site
106370008099	transcription antitermination factor NusB; Region: nusB; TIGR01951
106370008100	elongation factor P; Validated; Region: PRK00529
106370008101	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
106370008102	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
106370008103	RNA binding site [nucleotide binding]; other site
106370008104	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
106370008105	RNA binding site [nucleotide binding]; other site
106370008106	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
106370008107	dimer interface [polypeptide binding]; other site
106370008108	active site
106370008109	metal binding site [ion binding]; metal-binding site
106370008110	shikimate kinase; Reviewed; Region: aroK; PRK00131
106370008111	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
106370008112	ADP binding site [chemical binding]; other site
106370008113	magnesium binding site [ion binding]; other site
106370008114	putative shikimate binding site; other site
106370008115	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
106370008116	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
106370008117	Tetramer interface [polypeptide binding]; other site
106370008118	active site
106370008119	FMN-binding site [chemical binding]; other site
106370008120	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
106370008121	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
106370008122	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
106370008123	YceG-like family; Region: YceG; pfam02618
106370008124	proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666
106370008125	dimerization interface [polypeptide binding]; other site
106370008126	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
106370008127	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
106370008128	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
106370008129	motif 1; other site
106370008130	active site
106370008131	motif 2; other site
106370008132	motif 3; other site
106370008133	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
106370008134	DHHA1 domain; Region: DHHA1; pfam02272
106370008135	Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972
106370008136	recombination factor protein RarA; Reviewed; Region: PRK13342
106370008137	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
106370008138	Walker A motif; other site
106370008139	ATP binding site [chemical binding]; other site
106370008140	Walker B motif; other site
106370008141	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
106370008142	Transcriptional regulators [Transcription]; Region: FadR; COG2186
106370008143	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
106370008144	DNA-binding site [nucleotide binding]; DNA binding site
106370008145	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
106370008146	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
106370008147	active site
106370008148	HIGH motif; other site
106370008149	nucleotide binding site [chemical binding]; other site
106370008150	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
106370008151	active site
106370008152	KMSKS motif; other site
106370008153	Predicted transcriptional regulators [Transcription]; Region: COG1733
106370008154	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
106370008155	dimerization interface [polypeptide binding]; other site
106370008156	putative DNA binding site [nucleotide binding]; other site
106370008157	putative Zn2+ binding site [ion binding]; other site
106370008158	Transposase; Region: DEDD_Tnp_IS110; pfam01548
106370008159	Transposase; Region: DEDD_Tnp_IS110; pfam01548
106370008160	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
106370008161	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
106370008162	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
106370008163	putative catalytic site [active]
106370008164	putative metal binding site [ion binding]; other site
106370008165	putative phosphate binding site [ion binding]; other site
106370008166	NADH(P)-binding; Region: NAD_binding_10; pfam13460
106370008167	Male sterility protein; Region: NAD_binding_4; pfam07993
106370008168	NAD(P) binding site [chemical binding]; other site
106370008169	active site
106370008170	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
106370008171	CAAX protease self-immunity; Region: Abi; pfam02517
106370008172	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
106370008173	Major Facilitator Superfamily; Region: MFS_1; pfam07690
106370008174	putative substrate translocation pore; other site
106370008175	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370008176	S-adenosylmethionine binding site [chemical binding]; other site
106370008177	Transport protein; Region: actII; TIGR00833
106370008178	MMPL family; Region: MMPL; pfam03176
106370008179	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
106370008180	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683
106370008181	nudix motif; other site
106370008182	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
106370008183	dimerization interface [polypeptide binding]; other site
106370008184	putative DNA binding site [nucleotide binding]; other site
106370008185	putative Zn2+ binding site [ion binding]; other site
106370008186	Transposase; Region: DEDD_Tnp_IS110; pfam01548
106370008187	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
106370008188	Probable cobalt transporter subunit (CbtA); Region: CbtA; pfam09490
106370008189	Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406
106370008190	methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188
106370008191	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370008192	S-adenosylmethionine binding site [chemical binding]; other site
106370008193	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
106370008194	Sulfate transporter family; Region: Sulfate_transp; pfam00916
106370008195	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
106370008196	active site clefts [active]
106370008197	zinc binding site [ion binding]; other site
106370008198	dimer interface [polypeptide binding]; other site
106370008199	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
106370008200	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
106370008201	Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042
106370008202	Lamin Tail Domain; Region: LTD; pfam00932
106370008203	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
106370008204	pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029
106370008205	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
106370008206	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
106370008207	GAF domain; Region: GAF; pfam01590
106370008208	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
106370008209	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
106370008210	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
106370008211	Histidine kinase; Region: HisKA_3; pfam07730
106370008212	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
106370008213	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
106370008214	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
106370008215	active site
106370008216	phosphorylation site [posttranslational modification]
106370008217	intermolecular recognition site; other site
106370008218	dimerization interface [polypeptide binding]; other site
106370008219	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
106370008220	DNA binding residues [nucleotide binding]
106370008221	dimerization interface [polypeptide binding]; other site
106370008222	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
106370008223	CoA-transferase family III; Region: CoA_transf_3; pfam02515
106370008224	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
106370008225	Catalytic domain of Protein Kinases; Region: PKc; cd00180
106370008226	active site
106370008227	ATP binding site [chemical binding]; other site
106370008228	substrate binding site [chemical binding]; other site
106370008229	activation loop (A-loop); other site
106370008230	FOG: WD40 repeat [General function prediction only]; Region: COG2319
106370008231	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
106370008232	structural tetrad; other site
106370008233	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
106370008234	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
106370008235	DXD motif; other site
106370008236	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
106370008237	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
106370008238	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
106370008239	Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862
106370008240	putative hydrophobic ligand binding site [chemical binding]; other site
106370008241	Protein of unknown function (DUF2568); Region: DUF2568; pfam10823
106370008242	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
106370008243	Integrase core domain; Region: rve; pfam00665
106370008244	Transposase IS200 like; Region: Y1_Tnp; pfam01797
106370008245	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
106370008246	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
106370008247	Probable transposase; Region: OrfB_IS605; pfam01385
106370008248	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
106370008249	Probable transposase; Region: OrfB_IS605; pfam01385
106370008250	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
106370008251	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
106370008252	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
106370008253	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
106370008254	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
106370008255	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
106370008256	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
106370008257	acyl-activating enzyme (AAE) consensus motif; other site
106370008258	AMP binding site [chemical binding]; other site
106370008259	active site
106370008260	CoA binding site [chemical binding]; other site
106370008261	Cupin domain; Region: Cupin_2; pfam07883
106370008262	Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: MetG; COG0143
106370008263	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
106370008264	active site
106370008265	HIGH motif; other site
106370008266	nucleotide binding site [chemical binding]; other site
106370008267	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
106370008268	active site
106370008269	KMSKS motif; other site
106370008270	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
106370008271	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
106370008272	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
106370008273	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
106370008274	active site
106370008275	Protein of unknown function (DUF770); Region: DUF770; cl01402
106370008276	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
106370008277	active site
106370008278	catalytic triad [active]
106370008279	oxyanion hole [active]
106370008280	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
106370008281	dinuclear metal binding motif [ion binding]; other site
106370008282	Transglutaminase-like superfamily; Region: Transglut_core; cl17362
106370008283	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
106370008284	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
106370008285	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
106370008286	acyl-activating enzyme (AAE) consensus motif; other site
106370008287	active site
106370008288	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
106370008289	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
106370008290	Ligand Binding Site [chemical binding]; other site
106370008291	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
106370008292	dimer interface [polypeptide binding]; other site
106370008293	phosphorylation site [posttranslational modification]
106370008294	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
106370008295	ATP binding site [chemical binding]; other site
106370008296	Mg2+ binding site [ion binding]; other site
106370008297	G-X-G motif; other site
106370008298	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
106370008299	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
106370008300	active site
106370008301	phosphorylation site [posttranslational modification]
106370008302	intermolecular recognition site; other site
106370008303	dimerization interface [polypeptide binding]; other site
106370008304	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
106370008305	DNA binding site [nucleotide binding]
106370008306	K+-transporting ATPase, c chain; Region: KdpC; cl00944
106370008307	K+-transporting ATPase, c chain; Region: KdpC; cl00944
106370008308	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
106370008309	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
106370008310	Soluble P-type ATPase [General function prediction only]; Region: COG4087
106370008311	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
106370008312	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
106370008313	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
106370008314	active site
106370008315	phosphorylation site [posttranslational modification]
106370008316	intermolecular recognition site; other site
106370008317	dimerization interface [polypeptide binding]; other site
106370008318	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
106370008319	DNA binding site [nucleotide binding]
106370008320	Protein of unknown function DUF72; Region: DUF72; pfam01904
106370008321	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
106370008322	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
106370008323	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
106370008324	putative active site [active]
106370008325	Predicted transcriptional regulators [Transcription]; Region: COG1733
106370008326	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
106370008327	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
106370008328	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
106370008329	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
106370008330	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
106370008331	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
106370008332	putative Zn2+ binding site [ion binding]; other site
106370008333	Helix-turn-helix domain; Region: HTH_17; cl17695
106370008334	Helix-turn-helix domain; Region: HTH_17; pfam12728
106370008335	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
106370008336	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
106370008337	CHC2 zinc finger; Region: zf-CHC2; cl17510
106370008338	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
106370008339	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
106370008340	active site
106370008341	metal binding site [ion binding]; metal-binding site
106370008342	interdomain interaction site; other site
106370008343	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370008344	non-specific DNA binding site [nucleotide binding]; other site
106370008345	salt bridge; other site
106370008346	sequence-specific DNA binding site [nucleotide binding]; other site
106370008347	thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891
106370008348	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
106370008349	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
106370008350	LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793
106370008351	active site
106370008352	zinc binding site [ion binding]; other site
106370008353	Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737
106370008354	Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738
106370008355	SpaB C-terminal domain; Region: SpaB_C; cl14828
106370008356	methyltransferase, FxLD system; Region: methyltran_FxLD; TIGR04364
106370008357	Methyltransferase domain; Region: Methyltransf_18; pfam12847
106370008358	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
106370008359	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
106370008360	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
106370008361	putative trimer interface [polypeptide binding]; other site
106370008362	putative CoA binding site [chemical binding]; other site
106370008363	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
106370008364	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
106370008365	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
106370008366	AAA-like domain; Region: AAA_10; pfam12846
106370008367	Helix-turn-helix domain; Region: HTH_17; cl17695
106370008368	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
106370008369	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
106370008370	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
106370008371	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
106370008372	Walker A motif; other site
106370008373	ATP binding site [chemical binding]; other site
106370008374	Walker B motif; other site
106370008375	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
106370008376	Protein of unknown function (DUF2637); Region: DUF2637; pfam10935
106370008377	TrwC relaxase; Region: TrwC; pfam08751
106370008378	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
106370008379	AAA domain; Region: AAA_30; pfam13604
106370008380	Protein of unknown function (DUF2786); Region: DUF2786; pfam10979
106370008381	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
106370008382	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
106370008383	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
106370008384	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09651
106370008385	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
106370008386	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004
106370008387	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
106370008388	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
106370008389	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721
106370008390	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
106370008391	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
106370008392	active site
106370008393	DNA binding site [nucleotide binding]
106370008394	Int/Topo IB signature motif; other site
106370008395	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
106370008396	putative active site [active]
106370008397	Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
106370008398	benzoate transporter; Region: benE; TIGR00843
106370008399	Epoxide hydrolase N terminus; Region: EHN; pfam06441
106370008400	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
106370008401	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
106370008402	FeS/SAM binding site; other site
106370008403	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
106370008404	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
106370008405	putative substrate translocation pore; other site
106370008406	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
106370008407	putative substrate translocation pore; other site
106370008408	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
106370008409	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
106370008410	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
106370008411	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
106370008412	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
106370008413	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
106370008414	inhibitor-cofactor binding pocket; inhibition site
106370008415	pyridoxal 5'-phosphate binding site [chemical binding]; other site
106370008416	catalytic residue [active]
106370008417	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
106370008418	NAD(P) binding site [chemical binding]; other site
106370008419	putative phosphonate catabolism associated alcohol dehydrogenase; Region: HpnZ_proposed; TIGR03366
106370008420	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
106370008421	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
106370008422	Radical SAM superfamily; Region: Radical_SAM; pfam04055
106370008423	FeS/SAM binding site; other site
106370008424	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
106370008425	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
106370008426	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
106370008427	active site
106370008428	ATP binding site [chemical binding]; other site
106370008429	Phosphotransferase enzyme family; Region: APH; pfam01636
106370008430	antibiotic binding site [chemical binding]; other site
106370008431	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
106370008432	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
106370008433	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
106370008434	catalytic residue [active]
106370008435	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
106370008436	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
106370008437	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
106370008438	FeS/SAM binding site; other site
106370008439	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
106370008440	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
106370008441	Ribosomal RNA methyltransferase (FmrO); Region: FmrO; pfam07091
106370008442	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370008443	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
106370008444	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
106370008445	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
106370008446	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
106370008447	FeS/SAM binding site; other site
106370008448	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
106370008449	Uncharacterized conserved protein [Function unknown]; Region: COG2128
106370008450	Predicted methyltransferases [General function prediction only]; Region: COG0313
106370008451	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
106370008452	putative SAM binding site [chemical binding]; other site
106370008453	putative homodimer interface [polypeptide binding]; other site
106370008454	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
106370008455	Queuine tRNA-ribosyltransferase; Region: TGT; pfam01702
106370008456	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
106370008457	Ligand Binding Site [chemical binding]; other site
106370008458	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
106370008459	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
106370008460	FeS/SAM binding site; other site
106370008461	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
106370008462	active site
106370008463	Ribosomal RNA methyltransferase (FmrO); Region: FmrO; pfam07091
106370008464	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
106370008465	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
106370008466	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
106370008467	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
106370008468	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
106370008469	DDE superfamily endonuclease; Region: DDE_5; cl17874
106370008470	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
106370008471	active site
106370008472	DNA binding site [nucleotide binding]
106370008473	Int/Topo IB signature motif; other site
106370008474	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
106370008475	active site
106370008476	DNA binding site [nucleotide binding]
106370008477	Int/Topo IB signature motif; other site
106370008478	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370008479	non-specific DNA binding site [nucleotide binding]; other site
106370008480	salt bridge; other site
106370008481	sequence-specific DNA binding site [nucleotide binding]; other site
106370008482	Catalytic domain of Protein Kinases; Region: PKc; cd00180
106370008483	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
106370008484	active site
106370008485	ATP binding site [chemical binding]; other site
106370008486	substrate binding site [chemical binding]; other site
106370008487	activation loop (A-loop); other site
106370008488	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
106370008489	FOG: WD40 repeat [General function prediction only]; Region: COG2319
106370008490	structural tetrad; other site
106370008491	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
106370008492	Helix-turn-helix domain; Region: HTH_17; pfam12728
106370008493	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
106370008494	YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function.  The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336
106370008495	putative deacylase active site [active]
106370008496	Iron permease FTR1 family; Region: FTR1; cl00475
106370008497	Imelysin; Region: Peptidase_M75; pfam09375
106370008498	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
106370008499	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
106370008500	putative acetyltransferase; Provisional; Region: PRK03624
106370008501	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
106370008502	Coenzyme A binding pocket [chemical binding]; other site
106370008503	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
106370008504	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
106370008505	Walker A motif; other site
106370008506	ATP binding site [chemical binding]; other site
106370008507	Walker B motif; other site
106370008508	arginine finger; other site
106370008509	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
106370008510	active site
106370008511	dimer interface [polypeptide binding]; other site
106370008512	motif 1; other site
106370008513	motif 2; other site
106370008514	motif 3; other site
106370008515	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
106370008516	anticodon binding site; other site
106370008517	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
106370008518	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
106370008519	active site
106370008520	ATP binding site [chemical binding]; other site
106370008521	substrate binding site [chemical binding]; other site
106370008522	activation loop (A-loop); other site
106370008523	phosphopeptide binding site; other site
106370008524	FHA domain; Region: FHA; pfam00498
106370008525	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
106370008526	metal ion-dependent adhesion site (MIDAS); other site
106370008527	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
106370008528	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
106370008529	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
106370008530	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
106370008531	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
106370008532	active site
106370008533	catalytic tetrad [active]
106370008534	Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686
106370008535	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
106370008536	Catalytic domain of Protein Kinases; Region: PKc; cd00180
106370008537	active site
106370008538	ATP binding site [chemical binding]; other site
106370008539	substrate binding site [chemical binding]; other site
106370008540	activation loop (A-loop); other site
106370008541	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
106370008542	FOG: WD40 repeat [General function prediction only]; Region: COG2319
106370008543	structural tetrad; other site
106370008544	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
106370008545	Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563
106370008546	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
106370008547	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
106370008548	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
106370008549	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
106370008550	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
106370008551	substrate binding site [chemical binding]; other site
106370008552	oxyanion hole (OAH) forming residues; other site
106370008553	trimer interface [polypeptide binding]; other site
106370008554	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
106370008555	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
106370008556	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
106370008557	WYL domain; Region: WYL; pfam13280
106370008558	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
106370008559	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
106370008560	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
106370008561	Probable transposase; Region: OrfB_IS605; pfam01385
106370008562	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
106370008563	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
106370008564	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
106370008565	catalytic residues [active]
106370008566	catalytic nucleophile [active]
106370008567	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
106370008568	nudix motif; other site
106370008569	tellurite resistance protein terB; Region: terB; cd07176
106370008570	putative metal binding site [ion binding]; other site
106370008571	SCP-2 sterol transfer family; Region: SCP2; pfam02036
106370008572	hypothetical protein; Provisional; Region: PRK09266
106370008573	homodimer interface [polypeptide binding]; other site
106370008574	substrate-cofactor binding pocket; other site
106370008575	pyridoxal 5'-phosphate binding site [chemical binding]; other site
106370008576	catalytic residue [active]
106370008577	Transposase; Region: DEDD_Tnp_IS110; pfam01548
106370008578	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
106370008579	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
106370008580	Transposase; Region: DEDD_Tnp_IS110; pfam01548
106370008581	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
106370008582	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
106370008583	TIR domain; Region: TIR_2; pfam13676
106370008584	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
106370008585	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
106370008586	malate dehydrogenase; Provisional; Region: PRK05442
106370008587	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
106370008588	NAD(P) binding site [chemical binding]; other site
106370008589	dimer interface [polypeptide binding]; other site
106370008590	malate binding site [chemical binding]; other site
106370008591	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
106370008592	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
106370008593	putative ligand binding site [chemical binding]; other site
106370008594	Domain of unknown function (DUF336); Region: DUF336; cl01249
106370008595	Domain of unknown function (DUF397); Region: DUF397; pfam04149
106370008596	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370008597	non-specific DNA binding site [nucleotide binding]; other site
106370008598	salt bridge; other site
106370008599	sequence-specific DNA binding site [nucleotide binding]; other site
106370008600	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
106370008601	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
106370008602	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
106370008603	ATP binding site [chemical binding]; other site
106370008604	putative Mg++ binding site [ion binding]; other site
106370008605	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
106370008606	nucleotide binding region [chemical binding]; other site
106370008607	ATP-binding site [chemical binding]; other site
106370008608	Helicase associated domain (HA2); Region: HA2; pfam04408
106370008609	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
106370008610	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
106370008611	TIR domain; Region: TIR_2; pfam13676
106370008612	AAA ATPase domain; Region: AAA_16; pfam13191
106370008613	Tetratricopeptide repeat; Region: TPR_12; pfam13424
106370008614	Tetratricopeptide repeat; Region: TPR_10; pfam13374
106370008615	Tetratricopeptide repeat; Region: TPR_12; pfam13424
106370008616	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
106370008617	TPR motif; other site
106370008618	binding surface
106370008619	Tetratricopeptide repeat; Region: TPR_12; pfam13424
106370008620	Tetratricopeptide repeat; Region: TPR_12; pfam13424
106370008621	Tetratricopeptide repeat; Region: TPR_10; pfam13374
106370008622	Tetratricopeptide repeat; Region: TPR_12; pfam13424
106370008623	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
106370008624	binding surface
106370008625	TPR motif; other site
106370008626	Tetratricopeptide repeat; Region: TPR_12; pfam13424
106370008627	Tetratricopeptide repeat; Region: TPR_12; pfam13424
106370008628	Tetratricopeptide repeat; Region: TPR_12; pfam13424
106370008629	Tetratricopeptide repeat; Region: TPR_10; pfam13374
106370008630	Tetratricopeptide repeat; Region: TPR_10; pfam13374
106370008631	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
106370008632	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
106370008633	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
106370008634	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
106370008635	dimer interface [polypeptide binding]; other site
106370008636	active site
106370008637	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
106370008638	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
106370008639	DNA binding residues [nucleotide binding]
106370008640	dimer interface [polypeptide binding]; other site
106370008641	[2Fe-2S] cluster binding site [ion binding]; other site
106370008642	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
106370008643	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
106370008644	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
106370008645	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
106370008646	TM-ABC transporter signature motif; other site
106370008647	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
106370008648	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
106370008649	TM-ABC transporter signature motif; other site
106370008650	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
106370008651	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
106370008652	Walker A/P-loop; other site
106370008653	ATP binding site [chemical binding]; other site
106370008654	Q-loop/lid; other site
106370008655	ABC transporter signature motif; other site
106370008656	Walker B; other site
106370008657	D-loop; other site
106370008658	H-loop/switch region; other site
106370008659	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
106370008660	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
106370008661	Walker A/P-loop; other site
106370008662	ATP binding site [chemical binding]; other site
106370008663	Q-loop/lid; other site
106370008664	ABC transporter signature motif; other site
106370008665	Walker B; other site
106370008666	D-loop; other site
106370008667	H-loop/switch region; other site
106370008668	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
106370008669	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
106370008670	putative metal binding site [ion binding]; other site
106370008671	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
106370008672	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
106370008673	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
106370008674	N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445
106370008675	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
106370008676	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
106370008677	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
106370008678	catalytic residue [active]
106370008679	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
106370008680	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
106370008681	active site
106370008682	phosphorylation site [posttranslational modification]
106370008683	intermolecular recognition site; other site
106370008684	dimerization interface [polypeptide binding]; other site
106370008685	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
106370008686	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
106370008687	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
106370008688	active site
106370008689	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
106370008690	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
106370008691	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
106370008692	dimerization interface [polypeptide binding]; other site
106370008693	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
106370008694	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
106370008695	putative Iron-sulfur protein interface [polypeptide binding]; other site
106370008696	proximal heme binding site [chemical binding]; other site
106370008697	distal heme binding site [chemical binding]; other site
106370008698	putative dimer interface [polypeptide binding]; other site
106370008699	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
106370008700	L-aspartate oxidase; Provisional; Region: PRK06175
106370008701	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
106370008702	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
106370008703	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
106370008704	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
106370008705	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
106370008706	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
106370008707	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
106370008708	Protein of unknown function (DUF4012); Region: DUF4012; pfam13196
106370008709	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
106370008710	Chain length determinant protein; Region: Wzz; cl15801
106370008711	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
106370008712	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
106370008713	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
106370008714	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
106370008715	Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719
106370008716	NAD(P) binding site [chemical binding]; other site
106370008717	homodimer interface [polypeptide binding]; other site
106370008718	substrate binding site [chemical binding]; other site
106370008719	active site
106370008720	Protein of unknown function (DUF1356); Region: DUF1356; pfam07092
106370008721	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
106370008722	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
106370008723	NAD(P) binding site [chemical binding]; other site
106370008724	active site
106370008725	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
106370008726	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
106370008727	putative trimer interface [polypeptide binding]; other site
106370008728	putative CoA binding site [chemical binding]; other site
106370008729	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
106370008730	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
106370008731	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
106370008732	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
106370008733	N-acetyl-D-glucosamine binding site [chemical binding]; other site
106370008734	catalytic residue [active]
106370008735	S4 domain; Region: S4_2; pfam13275
106370008736	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
106370008737	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
106370008738	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
106370008739	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
106370008740	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
106370008741	dimer interface [polypeptide binding]; other site
106370008742	active site
106370008743	CoA binding pocket [chemical binding]; other site
106370008744	acyl carrier protein; Provisional; Region: acpP; PRK00982
106370008745	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
106370008746	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
106370008747	dimer interface [polypeptide binding]; other site
106370008748	active site
106370008749	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
106370008750	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
106370008751	H+ Antiporter protein; Region: 2A0121; TIGR00900
106370008752	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
106370008753	Walker A motif; other site
106370008754	ATP binding site [chemical binding]; other site
106370008755	Walker B motif; other site
106370008756	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
106370008757	Peptidase family M41; Region: Peptidase_M41; pfam01434
106370008758	MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804
106370008759	active site
106370008760	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
106370008761	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
106370008762	FeS/SAM binding site; other site
106370008763	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
106370008764	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
106370008765	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
106370008766	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
106370008767	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
106370008768	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
106370008769	proline aminopeptidase P II; Provisional; Region: PRK10879
106370008770	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
106370008771	active site
106370008772	Lsr2; Region: Lsr2; pfam11774
106370008773	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
106370008774	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
106370008775	Walker A/P-loop; other site
106370008776	ATP binding site [chemical binding]; other site
106370008777	Q-loop/lid; other site
106370008778	ABC transporter signature motif; other site
106370008779	Walker B; other site
106370008780	D-loop; other site
106370008781	H-loop/switch region; other site
106370008782	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
106370008783	PAS fold; Region: PAS_4; pfam08448
106370008784	putative active site [active]
106370008785	heme pocket [chemical binding]; other site
106370008786	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
106370008787	PAS fold; Region: PAS_3; pfam08447
106370008788	putative active site [active]
106370008789	heme pocket [chemical binding]; other site
106370008790	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
106370008791	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
106370008792	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
106370008793	ATP binding site [chemical binding]; other site
106370008794	Mg2+ binding site [ion binding]; other site
106370008795	G-X-G motif; other site
106370008796	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
106370008797	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
106370008798	Coenzyme A binding pocket [chemical binding]; other site
106370008799	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
106370008800	CoA binding domain; Region: CoA_binding_2; pfam13380
106370008801	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
106370008802	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
106370008803	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
106370008804	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
106370008805	active site
106370008806	Zn binding site [ion binding]; other site
106370008807	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
106370008808	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
106370008809	acyl-activating enzyme (AAE) consensus motif; other site
106370008810	AMP binding site [chemical binding]; other site
106370008811	active site
106370008812	CoA binding site [chemical binding]; other site
106370008813	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
106370008814	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
106370008815	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
106370008816	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
106370008817	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
106370008818	DNA binding residues [nucleotide binding]
106370008819	Trehalase; Region: Trehalase; cl17346
106370008820	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
106370008821	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
106370008822	protein-splicing catalytic site; other site
106370008823	thioester formation/cholesterol transfer; other site
106370008824	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
106370008825	active site
106370008826	vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556
106370008827	effector binding site; other site
106370008828	dimer interface [polypeptide binding]; other site
106370008829	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
106370008830	TSCPD domain; Region: TSCPD; pfam12637
106370008831	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
106370008832	ATP cone domain; Region: ATP-cone; pfam03477
106370008833	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
106370008834	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
106370008835	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
106370008836	LexA repressor; Validated; Region: PRK00215
106370008837	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
106370008838	Catalytic site [active]
106370008839	GTPases [General function prediction only]; Region: HflX; COG2262
106370008840	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
106370008841	HflX GTPase family; Region: HflX; cd01878
106370008842	G1 box; other site
106370008843	GTP/Mg2+ binding site [chemical binding]; other site
106370008844	Switch I region; other site
106370008845	G2 box; other site
106370008846	G3 box; other site
106370008847	Switch II region; other site
106370008848	G4 box; other site
106370008849	G5 box; other site
106370008850	Helix-turn-helix domain; Region: HTH_18; pfam12833
106370008851	Mitomycin C resistance protein (MRD); Region: MRD; cd07235
106370008852	dimer interface [polypeptide binding]; other site
106370008853	ligand binding site [chemical binding]; other site
106370008854	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
106370008855	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
106370008856	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
106370008857	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
106370008858	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
106370008859	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
106370008860	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
106370008861	The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951
106370008862	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
106370008863	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
106370008864	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
106370008865	FeS/SAM binding site; other site
106370008866	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
106370008867	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
106370008868	Walker A/P-loop; other site
106370008869	ATP binding site [chemical binding]; other site
106370008870	Q-loop/lid; other site
106370008871	ABC transporter signature motif; other site
106370008872	Walker B; other site
106370008873	D-loop; other site
106370008874	H-loop/switch region; other site
106370008875	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
106370008876	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
106370008877	substrate binding pocket [chemical binding]; other site
106370008878	membrane-bound complex binding site; other site
106370008879	hinge residues; other site
106370008880	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
106370008881	dimer interface [polypeptide binding]; other site
106370008882	conserved gate region; other site
106370008883	putative PBP binding loops; other site
106370008884	ABC-ATPase subunit interface; other site
106370008885	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
106370008886	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
106370008887	dimer interface [polypeptide binding]; other site
106370008888	conserved gate region; other site
106370008889	putative PBP binding loops; other site
106370008890	ABC-ATPase subunit interface; other site
106370008891	Domain of unknown function (DUF3552); Region: DUF3552; pfam12072
106370008892	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
106370008893	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
106370008894	Zn2+ binding site [ion binding]; other site
106370008895	Mg2+ binding site [ion binding]; other site
106370008896	recombination regulator RecX; Reviewed; Region: recX; PRK00117
106370008897	recombinase A; Provisional; Region: recA; PRK09354
106370008898	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
106370008899	hexamer interface [polypeptide binding]; other site
106370008900	Walker A motif; other site
106370008901	ATP binding site [chemical binding]; other site
106370008902	Walker B motif; other site
106370008903	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
106370008904	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
106370008905	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
106370008906	ATP binding site [chemical binding]; other site
106370008907	putative Mg++ binding site [ion binding]; other site
106370008908	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
106370008909	nucleotide binding region [chemical binding]; other site
106370008910	ATP-binding site [chemical binding]; other site
106370008911	DEAD/H associated; Region: DEAD_assoc; pfam08494
106370008912	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
106370008913	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
106370008914	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
106370008915	thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891
106370008916	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
106370008917	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
106370008918	active site
106370008919	zinc binding site [ion binding]; other site
106370008920	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
106370008921	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
106370008922	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
106370008923	active site
106370008924	catalytic residues [active]
106370008925	DNA binding site [nucleotide binding]
106370008926	Int/Topo IB signature motif; other site
106370008927	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
106370008928	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
106370008929	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
106370008930	dimerization interface [polypeptide binding]; other site
106370008931	DPS ferroxidase diiron center [ion binding]; other site
106370008932	ion pore; other site
106370008933	Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530
106370008934	sequence-specific DNA binding site [nucleotide binding]; other site
106370008935	salt bridge; other site
106370008936	competence damage-inducible protein A; Provisional; Region: PRK00549
106370008937	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
106370008938	putative MPT binding site; other site
106370008939	Competence-damaged protein; Region: CinA; pfam02464
106370008940	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
106370008941	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
106370008942	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
106370008943	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370008944	non-specific DNA binding site [nucleotide binding]; other site
106370008945	salt bridge; other site
106370008946	sequence-specific DNA binding site [nucleotide binding]; other site
106370008947	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
106370008948	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
106370008949	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
106370008950	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
106370008951	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
106370008952	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
106370008953	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
106370008954	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
106370008955	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
106370008956	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
106370008957	dimer interface [polypeptide binding]; other site
106370008958	active site
106370008959	catalytic residue [active]
106370008960	Acetokinase family; Region: Acetate_kinase; cl17229
106370008961	putative phosphoketolase; Provisional; Region: PRK05261
106370008962	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
106370008963	TPP-binding site; other site
106370008964	XFP C-terminal domain; Region: XFP_C; pfam09363
106370008965	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
106370008966	histidyl-tRNA synthetase; Region: hisS; TIGR00442
106370008967	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
106370008968	dimer interface [polypeptide binding]; other site
106370008969	motif 1; other site
106370008970	active site
106370008971	motif 2; other site
106370008972	motif 3; other site
106370008973	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
106370008974	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
106370008975	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
106370008976	UDP-glucose 4-epimerase; Region: PLN02240
106370008977	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
106370008978	NAD binding site [chemical binding]; other site
106370008979	homodimer interface [polypeptide binding]; other site
106370008980	active site
106370008981	substrate binding site [chemical binding]; other site
106370008982	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
106370008983	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
106370008984	NAD binding site [chemical binding]; other site
106370008985	putative substrate binding site 2 [chemical binding]; other site
106370008986	putative substrate binding site 1 [chemical binding]; other site
106370008987	active site
106370008988	dihydrodipicolinate reductase; Provisional; Region: PRK00048
106370008989	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
106370008990	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
106370008991	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
106370008992	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
106370008993	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
106370008994	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
106370008995	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
106370008996	RNase E interface [polypeptide binding]; other site
106370008997	trimer interface [polypeptide binding]; other site
106370008998	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
106370008999	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
106370009000	RNase E interface [polypeptide binding]; other site
106370009001	trimer interface [polypeptide binding]; other site
106370009002	active site
106370009003	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
106370009004	putative nucleic acid binding region [nucleotide binding]; other site
106370009005	G-X-X-G motif; other site
106370009006	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
106370009007	RNA binding site [nucleotide binding]; other site
106370009008	domain interface; other site
106370009009	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
106370009010	16S/18S rRNA binding site [nucleotide binding]; other site
106370009011	S13e-L30e interaction site [polypeptide binding]; other site
106370009012	25S rRNA binding site [nucleotide binding]; other site
106370009013	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
106370009014	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
106370009015	active site
106370009016	Riboflavin kinase; Region: Flavokinase; smart00904
106370009017	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
106370009018	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
106370009019	RNA binding site [nucleotide binding]; other site
106370009020	active site
106370009021	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
106370009022	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
106370009023	DHH family; Region: DHH; pfam01368
106370009024	DHHA1 domain; Region: DHHA1; pfam02272
106370009025	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
106370009026	Protein of unknown function (DUF503); Region: DUF503; pfam04456
106370009027	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
106370009028	translation initiation factor IF-2; Region: IF-2; TIGR00487
106370009029	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
106370009030	G1 box; other site
106370009031	putative GEF interaction site [polypeptide binding]; other site
106370009032	GTP/Mg2+ binding site [chemical binding]; other site
106370009033	Switch I region; other site
106370009034	G2 box; other site
106370009035	G3 box; other site
106370009036	Switch II region; other site
106370009037	G4 box; other site
106370009038	G5 box; other site
106370009039	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
106370009040	Translation-initiation factor 2; Region: IF-2; pfam11987
106370009041	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
106370009042	Protein of unknown function (DUF448); Region: DUF448; pfam04296
106370009043	putative RNA binding cleft [nucleotide binding]; other site
106370009044	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
106370009045	NusA N-terminal domain; Region: NusA_N; pfam08529
106370009046	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
106370009047	RNA binding site [nucleotide binding]; other site
106370009048	homodimer interface [polypeptide binding]; other site
106370009049	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
106370009050	G-X-X-G motif; other site
106370009051	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
106370009052	G-X-X-G motif; other site
106370009053	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
106370009054	putative oligomer interface [polypeptide binding]; other site
106370009055	putative RNA binding site [nucleotide binding]; other site
106370009056	Predicted transcriptional regulator [Transcription]; Region: COG1959
106370009057	Transcriptional regulator; Region: Rrf2; pfam02082
106370009058	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
106370009059	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
106370009060	dimer interface [polypeptide binding]; other site
106370009061	conserved gate region; other site
106370009062	putative PBP binding loops; other site
106370009063	ABC-ATPase subunit interface; other site
106370009064	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
106370009065	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
106370009066	Walker A/P-loop; other site
106370009067	ATP binding site [chemical binding]; other site
106370009068	Q-loop/lid; other site
106370009069	ABC transporter signature motif; other site
106370009070	Walker B; other site
106370009071	D-loop; other site
106370009072	H-loop/switch region; other site
106370009073	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
106370009074	NMT1-like family; Region: NMT1_2; pfam13379
106370009075	Predicted acetyltransferase [General function prediction only]; Region: COG3393
106370009076	Domain of unknown function (DUF4081); Region: DUF4081; pfam13312
106370009077	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
106370009078	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
106370009079	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
106370009080	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
106370009081	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
106370009082	active site
106370009083	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
106370009084	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
106370009085	putative substrate binding region [chemical binding]; other site
106370009086	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
106370009087	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
106370009088	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
106370009089	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
106370009090	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
106370009091	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
106370009092	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
106370009093	FeS/SAM binding site; other site
106370009094	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
106370009095	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
106370009096	ribosome recycling factor; Reviewed; Region: frr; PRK00083
106370009097	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
106370009098	hinge region; other site
106370009099	elongation factor Ts; Reviewed; Region: tsf; PRK12332
106370009100	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
106370009101	Elongation factor TS; Region: EF_TS; pfam00889
106370009102	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
106370009103	rRNA interaction site [nucleotide binding]; other site
106370009104	S8 interaction site; other site
106370009105	putative laminin-1 binding site; other site
106370009106	Peptidase family M23; Region: Peptidase_M23; pfam01551
106370009107	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
106370009108	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
106370009109	active site
106370009110	DNA binding site [nucleotide binding]
106370009111	Int/Topo IB signature motif; other site
106370009112	DNA protecting protein DprA; Region: dprA; TIGR00732
106370009113	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
106370009114	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
106370009115	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
106370009116	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
106370009117	Walker A motif; other site
106370009118	ATP binding site [chemical binding]; other site
106370009119	Walker B motif; other site
106370009120	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
106370009121	hypothetical protein; Reviewed; Region: PRK12497
106370009122	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
106370009123	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
106370009124	RNA/DNA hybrid binding site [nucleotide binding]; other site
106370009125	active site
106370009126	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
106370009127	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
106370009128	Catalytic site [active]
106370009129	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
106370009130	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
106370009131	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
106370009132	RimM N-terminal domain; Region: RimM; pfam01782
106370009133	PRC-barrel domain; Region: PRC; pfam05239
106370009134	hypothetical protein; Provisional; Region: PRK02821
106370009135	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
106370009136	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
106370009137	signal recognition particle protein; Provisional; Region: PRK10867
106370009138	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
106370009139	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
106370009140	GTP binding site [chemical binding]; other site
106370009141	Signal peptide binding domain; Region: SRP_SPB; pfam02978
106370009142	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
106370009143	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
106370009144	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
106370009145	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
106370009146	Walker A/P-loop; other site
106370009147	ATP binding site [chemical binding]; other site
106370009148	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
106370009149	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
106370009150	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
106370009151	ABC transporter signature motif; other site
106370009152	Walker B; other site
106370009153	D-loop; other site
106370009154	H-loop/switch region; other site
106370009155	Acylphosphatase; Region: Acylphosphatase; cl00551
106370009156	Protein of unknown function (DUF2786); Region: DUF2786; pfam10979
106370009157	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
106370009158	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
106370009159	DNA binding site [nucleotide binding]
106370009160	putative catalytic residues [active]
106370009161	turnover-facilitating residue; other site
106370009162	intercalation triad [nucleotide binding]; other site
106370009163	8OG recognition residue [nucleotide binding]; other site
106370009164	putative reading head residues; other site
106370009165	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
106370009166	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
106370009167	ribonuclease III; Reviewed; Region: rnc; PRK00102
106370009168	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
106370009169	dimerization interface [polypeptide binding]; other site
106370009170	active site
106370009171	metal binding site [ion binding]; metal-binding site
106370009172	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
106370009173	Fatty acid synthesis protein; Region: FA_synthesis; cl17261
106370009174	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
106370009175	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
106370009176	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
106370009177	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
106370009178	active site
106370009179	(T/H)XGH motif; other site
106370009180	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
106370009181	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370009182	S-adenosylmethionine binding site [chemical binding]; other site
106370009183	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
106370009184	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
106370009185	generic binding surface II; other site
106370009186	ssDNA binding site; other site
106370009187	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
106370009188	ATP binding site [chemical binding]; other site
106370009189	putative Mg++ binding site [ion binding]; other site
106370009190	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
106370009191	nucleotide binding region [chemical binding]; other site
106370009192	ATP-binding site [chemical binding]; other site
106370009193	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
106370009194	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
106370009195	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
106370009196	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
106370009197	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
106370009198	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
106370009199	AsnC family; Region: AsnC_trans_reg; pfam01037
106370009200	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
106370009201	substrate binding site [chemical binding]; other site
106370009202	dimer interface [polypeptide binding]; other site
106370009203	ATP binding site [chemical binding]; other site
106370009204	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
106370009205	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
106370009206	hinge; other site
106370009207	active site
106370009208	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
106370009209	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
106370009210	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
106370009211	2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552
106370009212	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
106370009213	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
106370009214	metal binding site [ion binding]; metal-binding site
106370009215	active site
106370009216	I-site; other site
106370009217	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
106370009218	polyphosphate kinase; Provisional; Region: PRK05443
106370009219	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
106370009220	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
106370009221	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
106370009222	putative domain interface [polypeptide binding]; other site
106370009223	putative active site [active]
106370009224	catalytic site [active]
106370009225	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
106370009226	putative active site [active]
106370009227	catalytic site [active]
106370009228	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
106370009229	IHF - DNA interface [nucleotide binding]; other site
106370009230	IHF dimer interface [polypeptide binding]; other site
106370009231	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
106370009232	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
106370009233	substrate binding site [chemical binding]; other site
106370009234	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
106370009235	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
106370009236	substrate binding site [chemical binding]; other site
106370009237	ligand binding site [chemical binding]; other site
106370009238	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
106370009239	Transcriptional regulator [Transcription]; Region: IclR; COG1414
106370009240	Bacterial transcriptional regulator; Region: IclR; pfam01614
106370009241	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
106370009242	Catalytic domain of Protein Kinases; Region: PKc; cd00180
106370009243	active site
106370009244	ATP binding site [chemical binding]; other site
106370009245	substrate binding site [chemical binding]; other site
106370009246	activation loop (A-loop); other site
106370009247	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
106370009248	PASTA domain; Region: PASTA; smart00740
106370009249	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
106370009250	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
106370009251	dimer interface [polypeptide binding]; other site
106370009252	phosphorylation site [posttranslational modification]
106370009253	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
106370009254	ATP binding site [chemical binding]; other site
106370009255	Mg2+ binding site [ion binding]; other site
106370009256	G-X-G motif; other site
106370009257	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
106370009258	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
106370009259	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
106370009260	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
106370009261	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
106370009262	active site
106370009263	catalytic residues [active]
106370009264	metal binding site [ion binding]; metal-binding site
106370009265	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
106370009266	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
106370009267	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
106370009268	ligand binding site [chemical binding]; other site
106370009269	flexible hinge region; other site
106370009270	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
106370009271	putative switch regulator; other site
106370009272	non-specific DNA interactions [nucleotide binding]; other site
106370009273	DNA binding site [nucleotide binding]
106370009274	sequence specific DNA binding site [nucleotide binding]; other site
106370009275	putative cAMP binding site [chemical binding]; other site
106370009276	FOG: CBS domain [General function prediction only]; Region: COG0517
106370009277	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_11; cd04624
106370009278	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
106370009279	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
106370009280	homodimer interface [polypeptide binding]; other site
106370009281	substrate-cofactor binding pocket; other site
106370009282	catalytic residue [active]
106370009283	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
106370009284	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
106370009285	Protein of unknown function (DUF1059); Region: DUF1059; pfam06348
106370009286	2-isopropylmalate synthase; Validated; Region: PRK03739
106370009287	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
106370009288	active site
106370009289	catalytic residues [active]
106370009290	metal binding site [ion binding]; metal-binding site
106370009291	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
106370009292	Septum formation; Region: Septum_form; pfam13845
106370009293	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
106370009294	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
106370009295	ligand binding site [chemical binding]; other site
106370009296	NAD binding site [chemical binding]; other site
106370009297	dimerization interface [polypeptide binding]; other site
106370009298	catalytic site [active]
106370009299	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
106370009300	putative L-serine binding site [chemical binding]; other site
106370009301	ketol-acid reductoisomerase; Provisional; Region: PRK05479
106370009302	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
106370009303	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
106370009304	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
106370009305	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
106370009306	putative valine binding site [chemical binding]; other site
106370009307	dimer interface [polypeptide binding]; other site
106370009308	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
106370009309	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
106370009310	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
106370009311	PYR/PP interface [polypeptide binding]; other site
106370009312	dimer interface [polypeptide binding]; other site
106370009313	TPP binding site [chemical binding]; other site
106370009314	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
106370009315	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
106370009316	TPP-binding site [chemical binding]; other site
106370009317	dimer interface [polypeptide binding]; other site
106370009318	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
106370009319	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
106370009320	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
106370009321	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
106370009322	GatB domain; Region: GatB_Yqey; smart00845
106370009323	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
106370009324	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
106370009325	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
106370009326	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
106370009327	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
106370009328	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
106370009329	nucleotide binding pocket [chemical binding]; other site
106370009330	K-X-D-G motif; other site
106370009331	catalytic site [active]
106370009332	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
106370009333	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
106370009334	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
106370009335	Dimer interface [polypeptide binding]; other site
106370009336	CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310
106370009337	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
106370009338	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
106370009339	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
106370009340	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
106370009341	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
106370009342	catalytic residue [active]
106370009343	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
106370009344	MarR family; Region: MarR; pfam01047
106370009345	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
106370009346	B12 binding site [chemical binding]; other site
106370009347	cobalt ligand [ion binding]; other site
106370009348	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
106370009349	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
106370009350	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
106370009351	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
106370009352	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
106370009353	nucleotide binding site [chemical binding]; other site
106370009354	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
106370009355	active site
106370009356	ATP binding site [chemical binding]; other site
106370009357	von Willebrand factor (vWF) type A domain; Region: VWA; smart00327
106370009358	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
106370009359	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
106370009360	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
106370009361	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
106370009362	Ligand binding site [chemical binding]; other site
106370009363	Electron transfer flavoprotein domain; Region: ETF; pfam01012
106370009364	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
106370009365	putative catalytic site [active]
106370009366	putative metal binding site [ion binding]; other site
106370009367	putative phosphate binding site [ion binding]; other site
106370009368	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
106370009369	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
106370009370	substrate binding site [chemical binding]; other site
106370009371	oxyanion hole (OAH) forming residues; other site
106370009372	trimer interface [polypeptide binding]; other site
106370009373	acetyl-CoA synthetase; Provisional; Region: PRK00174
106370009374	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
106370009375	active site
106370009376	CoA binding site [chemical binding]; other site
106370009377	acyl-activating enzyme (AAE) consensus motif; other site
106370009378	AMP binding site [chemical binding]; other site
106370009379	acetate binding site [chemical binding]; other site
106370009380	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
106370009381	putative homodimer interface [polypeptide binding]; other site
106370009382	putative active site pocket [active]
106370009383	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
106370009384	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
106370009385	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
106370009386	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
106370009387	active site
106370009388	catalytic site [active]
106370009389	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
106370009390	active site
106370009391	KMSKS motif; other site
106370009392	Protein of unknown function (DUF2983); Region: DUF2983; pfam11202
106370009393	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
106370009394	active site
106370009395	Protein of unknown function (DUF3706); Region: DUF3706; pfam12500
106370009396	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
106370009397	Double zinc ribbon; Region: DZR; pfam12773
106370009398	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
106370009399	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
106370009400	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
106370009401	nucleotide binding site [chemical binding]; other site
106370009402	putative NEF/HSP70 interaction site [polypeptide binding]; other site
106370009403	SBD interface [polypeptide binding]; other site
106370009404	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
106370009405	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
106370009406	Tellurium resistance protein; Region: Tellurium_res; pfam10138
106370009407	Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110
106370009408	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
106370009409	hypothetical protein; Provisional; Region: PRK14013
106370009410	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
106370009411	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
106370009412	putative metal binding site [ion binding]; other site
106370009413	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
106370009414	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
106370009415	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
106370009416	active site
106370009417	homodimer interface [polypeptide binding]; other site
106370009418	catalytic site [active]
106370009419	acceptor binding site [chemical binding]; other site
106370009420	trehalose synthase; Region: treS_nterm; TIGR02456
106370009421	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
106370009422	active site
106370009423	catalytic site [active]
106370009424	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
106370009425	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
106370009426	glycogen branching enzyme; Provisional; Region: PRK05402
106370009427	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
106370009428	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
106370009429	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
106370009430	active site
106370009431	catalytic site [active]
106370009432	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
106370009433	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
106370009434	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
106370009435	Domain of unknown function DUF77; Region: DUF77; pfam01910
106370009436	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
106370009437	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
106370009438	dimer interface [polypeptide binding]; other site
106370009439	phosphorylation site [posttranslational modification]
106370009440	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
106370009441	ATP binding site [chemical binding]; other site
106370009442	Mg2+ binding site [ion binding]; other site
106370009443	G-X-G motif; other site
106370009444	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
106370009445	putative acyltransferase; Provisional; Region: PRK05790
106370009446	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
106370009447	dimer interface [polypeptide binding]; other site
106370009448	active site
106370009449	Family description; Region: VCBS; pfam13517
106370009450	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
106370009451	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
106370009452	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
106370009453	DNA binding residues [nucleotide binding]
106370009454	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
106370009455	crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751
106370009456	NAD(P) binding site [chemical binding]; other site
106370009457	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
106370009458	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
106370009459	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
106370009460	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
106370009461	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
106370009462	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
106370009463	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
106370009464	hypothetical protein; Provisional; Region: PRK03298
106370009465	HD domain; Region: HD_4; pfam13328
106370009466	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
106370009467	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
106370009468	hinge; other site
106370009469	active site
106370009470	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
106370009471	nudix motif; other site
106370009472	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
106370009473	PemK-like protein; Region: PemK; pfam02452
106370009474	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13442
106370009475	gamma subunit interface [polypeptide binding]; other site
106370009476	epsilon subunit interface [polypeptide binding]; other site
106370009477	LBP interface [polypeptide binding]; other site
106370009478	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
106370009479	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
106370009480	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
106370009481	alpha subunit interaction interface [polypeptide binding]; other site
106370009482	Walker A motif; other site
106370009483	ATP binding site [chemical binding]; other site
106370009484	Walker B motif; other site
106370009485	inhibitor binding site; inhibition site
106370009486	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
106370009487	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
106370009488	core domain interface [polypeptide binding]; other site
106370009489	delta subunit interface [polypeptide binding]; other site
106370009490	epsilon subunit interface [polypeptide binding]; other site
106370009491	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
106370009492	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
106370009493	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
106370009494	beta subunit interaction interface [polypeptide binding]; other site
106370009495	Walker A motif; other site
106370009496	ATP binding site [chemical binding]; other site
106370009497	Walker B motif; other site
106370009498	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
106370009499	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430
106370009500	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
106370009501	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
106370009502	ATP synthase subunit C; Region: ATP-synt_C; cl00466
106370009503	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
106370009504	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
106370009505	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
106370009506	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
106370009507	Mg++ binding site [ion binding]; other site
106370009508	putative catalytic motif [active]
106370009509	substrate binding site [chemical binding]; other site
106370009510	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
106370009511	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
106370009512	dimer interface [polypeptide binding]; other site
106370009513	active site
106370009514	glycine-pyridoxal phosphate binding site [chemical binding]; other site
106370009515	folate binding site [chemical binding]; other site
106370009516	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
106370009517	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
106370009518	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370009519	peptide chain release factor 1; Validated; Region: prfA; PRK00591
106370009520	PCRF domain; Region: PCRF; pfam03462
106370009521	RF-1 domain; Region: RF-1; pfam00472
106370009522	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
106370009523	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
106370009524	transcription termination factor Rho; Provisional; Region: PRK12608
106370009525	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
106370009526	RNA binding site [nucleotide binding]; other site
106370009527	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
106370009528	multimer interface [polypeptide binding]; other site
106370009529	Walker A motif; other site
106370009530	ATP binding site [chemical binding]; other site
106370009531	Walker B motif; other site
106370009532	homoserine kinase; Provisional; Region: PRK01212
106370009533	homoserine kinase; Provisional; Region: PRK01212
106370009534	threonine synthase; Reviewed; Region: PRK06721
106370009535	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
106370009536	homodimer interface [polypeptide binding]; other site
106370009537	pyridoxal 5'-phosphate binding site [chemical binding]; other site
106370009538	catalytic residue [active]
106370009539	homoserine dehydrogenase; Provisional; Region: PRK06349
106370009540	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
106370009541	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
106370009542	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
106370009543	diaminopimelate decarboxylase; Region: lysA; TIGR01048
106370009544	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
106370009545	active site
106370009546	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
106370009547	substrate binding site [chemical binding]; other site
106370009548	catalytic residues [active]
106370009549	dimer interface [polypeptide binding]; other site
106370009550	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
106370009551	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
106370009552	active site
106370009553	HIGH motif; other site
106370009554	nucleotide binding site [chemical binding]; other site
106370009555	DALR anticodon binding domain; Region: DALR_1; smart00836
106370009556	anticodon binding site; other site
106370009557	tRNA binding surface [nucleotide binding]; other site
106370009558	Response regulator receiver domain; Region: Response_reg; pfam00072
106370009559	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
106370009560	active site
106370009561	phosphorylation site [posttranslational modification]
106370009562	intermolecular recognition site; other site
106370009563	dimerization interface [polypeptide binding]; other site
106370009564	Methyltransferase domain; Region: Methyltransf_31; pfam13847
106370009565	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370009566	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
106370009567	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
106370009568	putative active site [active]
106370009569	putative NTP binding site [chemical binding]; other site
106370009570	putative nucleic acid binding site [nucleotide binding]; other site
106370009571	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
106370009572	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
106370009573	Transposase; Region: DDE_Tnp_ISL3; pfam01610
106370009574	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
106370009575	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899
106370009576	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
106370009577	active site
106370009578	Int/Topo IB signature motif; other site
106370009579	DNA binding site [nucleotide binding]
106370009580	Predicted membrane protein (DUF2127); Region: DUF2127; pfam09900
106370009581	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
106370009582	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
106370009583	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
106370009584	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
106370009585	metal binding site [ion binding]; metal-binding site
106370009586	active site
106370009587	I-site; other site
106370009588	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
106370009589	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
106370009590	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
106370009591	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
106370009592	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
106370009593	catalytic residue [active]
106370009594	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370009595	S-adenosylmethionine binding site [chemical binding]; other site
106370009596	PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379
106370009597	Part of AAA domain; Region: AAA_19; pfam13245
106370009598	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
106370009599	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
106370009600	Family description; Region: UvrD_C_2; pfam13538
106370009601	Part of AAA domain; Region: AAA_19; pfam13245
106370009602	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
106370009603	AAA domain; Region: AAA_12; pfam13087
106370009604	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
106370009605	putative active site [active]
106370009606	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
106370009607	thiamine monophosphate kinase; Provisional; Region: PRK05731
106370009608	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
106370009609	ATP binding site [chemical binding]; other site
106370009610	dimerization interface [polypeptide binding]; other site
106370009611	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
106370009612	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
106370009613	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
106370009614	TPP-binding site [chemical binding]; other site
106370009615	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
106370009616	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
106370009617	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
106370009618	NAD(P) binding site [chemical binding]; other site
106370009619	Malic enzyme, N-terminal domain; Region: malic; pfam00390
106370009620	Malic enzyme, NAD binding domain; Region: Malic_M; smart00919
106370009621	NAD(P) binding pocket [chemical binding]; other site
106370009622	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
106370009623	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
106370009624	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
106370009625	Coenzyme A binding pocket [chemical binding]; other site
106370009626	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
106370009627	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
106370009628	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
106370009629	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
106370009630	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
106370009631	DNA binding residues [nucleotide binding]
106370009632	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
106370009633	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
106370009634	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
106370009635	Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
106370009636	active site
106370009637	catalytic site [active]
106370009638	metal binding site [ion binding]; metal-binding site
106370009639	Transcription factor WhiB; Region: Whib; pfam02467
106370009640	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
106370009641	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
106370009642	Histidine kinase; Region: HisKA_2; pfam07568
106370009643	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
106370009644	ATP binding site [chemical binding]; other site
106370009645	Mg2+ binding site [ion binding]; other site
106370009646	G-X-G motif; other site
106370009647	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
106370009648	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
106370009649	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
106370009650	catalytic residue [active]
106370009651	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
106370009652	biotin synthase; Validated; Region: PRK06256
106370009653	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
106370009654	FeS/SAM binding site; other site
106370009655	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
106370009656	PAS fold; Region: PAS_4; pfam08448
106370009657	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
106370009658	putative active site [active]
106370009659	heme pocket [chemical binding]; other site
106370009660	GAF domain; Region: GAF_2; pfam13185
106370009661	GAF domain; Region: GAF; cl17456
106370009662	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
106370009663	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
106370009664	carboxyltransferase (CT) interaction site; other site
106370009665	biotinylation site [posttranslational modification]; other site
106370009666	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988
106370009667	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
106370009668	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
106370009669	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
106370009670	DNA binding residues [nucleotide binding]
106370009671	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
106370009672	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
106370009673	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
106370009674	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
106370009675	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
106370009676	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
106370009677	hinge; other site
106370009678	active site
106370009679	ribosome small subunit-dependent GTPase A; Region: TIGR00157
106370009680	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
106370009681	GTPase/Zn-binding domain interface [polypeptide binding]; other site
106370009682	GTP/Mg2+ binding site [chemical binding]; other site
106370009683	G4 box; other site
106370009684	G1 box; other site
106370009685	Switch I region; other site
106370009686	G2 box; other site
106370009687	G3 box; other site
106370009688	Switch II region; other site
106370009689	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
106370009690	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
106370009691	active site
106370009692	Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
106370009693	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
106370009694	active site
106370009695	catalytic site [active]
106370009696	metal binding site [ion binding]; metal-binding site
106370009697	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
106370009698	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
106370009699	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
106370009700	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
106370009701	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
106370009702	tetrameric interface [polypeptide binding]; other site
106370009703	NAD binding site [chemical binding]; other site
106370009704	catalytic residues [active]
106370009705	substrate binding site [chemical binding]; other site
106370009706	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
106370009707	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
106370009708	inhibitor-cofactor binding pocket; inhibition site
106370009709	pyridoxal 5'-phosphate binding site [chemical binding]; other site
106370009710	catalytic residue [active]
106370009711	dimerization interface [polypeptide binding]; other site
106370009712	putative DNA binding site [nucleotide binding]; other site
106370009713	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
106370009714	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
106370009715	putative Zn2+ binding site [ion binding]; other site
106370009716	AsnC family; Region: AsnC_trans_reg; pfam01037
106370009717	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
106370009718	Uncharacterized conserved protein [Function unknown]; Region: COG1615
106370009719	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
106370009720	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
106370009721	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
106370009722	MoaE homodimer interface [polypeptide binding]; other site
106370009723	MoaD interaction [polypeptide binding]; other site
106370009724	active site residues [active]
106370009725	Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103
106370009726	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
106370009727	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
106370009728	ABC1 family; Region: ABC1; pfam03109
106370009729	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
106370009730	active site
106370009731	ATP binding site [chemical binding]; other site
106370009732	Transcription factor WhiB; Region: Whib; pfam02467
106370009733	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
106370009734	Family description; Region: UvrD_C_2; pfam13538
106370009735	HRDC domain; Region: HRDC; pfam00570
106370009736	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
106370009737	catalytic residues [active]
106370009738	ANTAR domain; Region: ANTAR; pfam03861
106370009739	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
106370009740	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
106370009741	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
106370009742	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
106370009743	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
106370009744	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
106370009745	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
106370009746	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
106370009747	putative metal binding site [ion binding]; other site
106370009748	putative catalytic site [active]
106370009749	putative phosphate binding site [ion binding]; other site
106370009750	putative metal binding site [ion binding]; other site
106370009751	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
106370009752	Family description; Region: UvrD_C_2; pfam13538
106370009753	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
106370009754	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
106370009755	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
106370009756	Family description; Region: UvrD_C_2; pfam13538
106370009757	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
106370009758	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
106370009759	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
106370009760	NAD(P) binding site [chemical binding]; other site
106370009761	active site
106370009762	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
106370009763	DNA binding site [nucleotide binding]
106370009764	active site
106370009765	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
106370009766	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
106370009767	ATP binding site [chemical binding]; other site
106370009768	substrate interface [chemical binding]; other site
106370009769	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
106370009770	active site residue [active]
106370009771	CsbD-like; Region: CsbD; pfam05532
106370009772	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
106370009773	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
106370009774	putative DNA binding site [nucleotide binding]; other site
106370009775	putative homodimer interface [polypeptide binding]; other site
106370009776	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
106370009777	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
106370009778	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
106370009779	tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794
106370009780	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
106370009781	DEAD-like helicases superfamily; Region: DEXDc; smart00487
106370009782	ATP binding site [chemical binding]; other site
106370009783	Mg++ binding site [ion binding]; other site
106370009784	motif III; other site
106370009785	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
106370009786	nucleotide binding region [chemical binding]; other site
106370009787	ATP-binding site [chemical binding]; other site
106370009788	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
106370009789	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
106370009790	P-loop; other site
106370009791	Magnesium ion binding site [ion binding]; other site
106370009792	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
106370009793	Magnesium ion binding site [ion binding]; other site
106370009794	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
106370009795	hypothetical protein; Provisional; Region: PRK08912
106370009796	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
106370009797	pyridoxal 5'-phosphate binding site [chemical binding]; other site
106370009798	homodimer interface [polypeptide binding]; other site
106370009799	catalytic residue [active]
106370009800	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
106370009801	hypothetical protein; Provisional; Region: PRK07857
106370009802	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
106370009803	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
106370009804	MgtE intracellular N domain; Region: MgtE_N; smart00924
106370009805	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
106370009806	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
106370009807	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
106370009808	putative metal binding site [ion binding]; other site
106370009809	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
106370009810	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
106370009811	putative metal binding site [ion binding]; other site
106370009812	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
106370009813	PhoD-like phosphatase; Region: PhoD; pfam09423
106370009814	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
106370009815	putative active site [active]
106370009816	putative metal binding site [ion binding]; other site
106370009817	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
106370009818	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
106370009819	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
106370009820	D-pathway; other site
106370009821	Putative ubiquinol binding site [chemical binding]; other site
106370009822	Low-spin heme (heme b) binding site [chemical binding]; other site
106370009823	Putative water exit pathway; other site
106370009824	Binuclear center (heme o3/CuB) [ion binding]; other site
106370009825	K-pathway; other site
106370009826	Putative proton exit pathway; other site
106370009827	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
106370009828	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465
106370009829	4-aminobutyrate aminotransferase; Provisional; Region: PRK06058
106370009830	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
106370009831	inhibitor-cofactor binding pocket; inhibition site
106370009832	pyridoxal 5'-phosphate binding site [chemical binding]; other site
106370009833	catalytic residue [active]
106370009834	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
106370009835	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
106370009836	NAD(P) binding site [chemical binding]; other site
106370009837	catalytic residues [active]
106370009838	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
106370009839	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
106370009840	active site
106370009841	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
106370009842	Transcriptional regulators [Transcription]; Region: MarR; COG1846
106370009843	MarR family; Region: MarR; pfam01047
106370009844	Domain of unknown function DUF59; Region: DUF59; cl00941
106370009845	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
106370009846	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
106370009847	sec-independent translocase; Provisional; Region: PRK01371
106370009848	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
106370009849	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
106370009850	protein binding site [polypeptide binding]; other site
106370009851	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
106370009852	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
106370009853	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
106370009854	DNA binding residues [nucleotide binding]
106370009855	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
106370009856	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370009857	S-adenosylmethionine binding site [chemical binding]; other site
106370009858	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
106370009859	interface (dimer of trimers) [polypeptide binding]; other site
106370009860	Substrate-binding/catalytic site; other site
106370009861	Zn-binding sites [ion binding]; other site
106370009862	Protein of unknown function (DUF3117); Region: DUF3117; pfam11314
106370009863	DivIVA domain; Region: DivI1A_domain; TIGR03544
106370009864	dihydropteroate synthase; Region: DHPS; TIGR01496
106370009865	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
106370009866	substrate binding pocket [chemical binding]; other site
106370009867	dimer interface [polypeptide binding]; other site
106370009868	inhibitor binding site; inhibition site
106370009869	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
106370009870	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
106370009871	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
106370009872	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
106370009873	trimer interface [polypeptide binding]; other site
106370009874	active site
106370009875	substrate binding site [chemical binding]; other site
106370009876	CoA binding site [chemical binding]; other site
106370009877	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
106370009878	active site
106370009879	catalytic residues [active]
106370009880	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
106370009881	TIGR01777 family protein; Region: yfcH
106370009882	NAD(P) binding site [chemical binding]; other site
106370009883	active site
106370009884	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
106370009885	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
106370009886	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
106370009887	active site
106370009888	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
106370009889	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
106370009890	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
106370009891	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
106370009892	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
106370009893	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
106370009894	Ligand binding site; other site
106370009895	Putative Catalytic site; other site
106370009896	DXD motif; other site
106370009897	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
106370009898	Bacterial sugar transferase; Region: Bac_transf; pfam02397
106370009899	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
106370009900	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
106370009901	metal binding site [ion binding]; metal-binding site
106370009902	putative dimer interface [polypeptide binding]; other site
106370009903	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
106370009904	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
106370009905	trimer interface [polypeptide binding]; other site
106370009906	active site
106370009907	substrate binding site [chemical binding]; other site
106370009908	CoA binding site [chemical binding]; other site
106370009909	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
106370009910	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
106370009911	pyridoxal 5'-phosphate binding site [chemical binding]; other site
106370009912	homodimer interface [polypeptide binding]; other site
106370009913	catalytic residue [active]
106370009914	Ferredoxin [Energy production and conversion]; Region: COG1146
106370009915	4Fe-4S binding domain; Region: Fer4; pfam00037
106370009916	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
106370009917	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
106370009918	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
106370009919	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
106370009920	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
106370009921	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
106370009922	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
106370009923	G1 box; other site
106370009924	putative GEF interaction site [polypeptide binding]; other site
106370009925	GTP/Mg2+ binding site [chemical binding]; other site
106370009926	Switch I region; other site
106370009927	G2 box; other site
106370009928	G3 box; other site
106370009929	Switch II region; other site
106370009930	G4 box; other site
106370009931	G5 box; other site
106370009932	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
106370009933	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
106370009934	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
106370009935	active site
106370009936	8-oxo-dGMP binding site [chemical binding]; other site
106370009937	nudix motif; other site
106370009938	metal binding site [ion binding]; metal-binding site
106370009939	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
106370009940	aromatic arch; other site
106370009941	DCoH dimer interaction site [polypeptide binding]; other site
106370009942	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
106370009943	DCoH tetramer interaction site [polypeptide binding]; other site
106370009944	substrate binding site [chemical binding]; other site
106370009945	Protein of unknown function (DUF952); Region: DUF952; pfam06108
106370009946	GTP-binding protein YchF; Reviewed; Region: PRK09601
106370009947	YchF GTPase; Region: YchF; cd01900
106370009948	G1 box; other site
106370009949	GTP/Mg2+ binding site [chemical binding]; other site
106370009950	Switch I region; other site
106370009951	G2 box; other site
106370009952	Switch II region; other site
106370009953	G3 box; other site
106370009954	G4 box; other site
106370009955	G5 box; other site
106370009956	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
106370009957	RmuC family; Region: RmuC; pfam02646
106370009958	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
106370009959	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
106370009960	putative active site [active]
106370009961	putative metal binding site [ion binding]; other site
106370009962	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
106370009963	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
106370009964	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
106370009965	putative active site [active]
106370009966	Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
106370009967	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
106370009968	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
106370009969	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
106370009970	generic binding surface II; other site
106370009971	generic binding surface I; other site
106370009972	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
106370009973	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
106370009974	fumarate hydratase; Reviewed; Region: fumC; PRK00485
106370009975	aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596
106370009976	active sites [active]
106370009977	tetramer interface [polypeptide binding]; other site
106370009978	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
106370009979	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
106370009980	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
106370009981	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
106370009982	Predicted transcriptional regulators [Transcription]; Region: COG1733
106370009983	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
106370009984	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
106370009985	nudix motif; other site
106370009986	adenylate kinase; Reviewed; Region: adk; PRK00279
106370009987	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
106370009988	AMP-binding site [chemical binding]; other site
106370009989	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
106370009990	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
106370009991	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
106370009992	active site
106370009993	motif I; other site
106370009994	motif II; other site
106370009995	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
106370009996	methyltransferase, FxLD system; Region: methyltran_FxLD; TIGR04364
106370009997	methionine sulfoxide reductase A; Provisional; Region: PRK00058
106370009998	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
106370009999	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
106370010000	putative active site [active]
106370010001	PhoH-like protein; Region: PhoH; pfam02562
106370010002	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
106370010003	active site
106370010004	substrate-binding site [chemical binding]; other site
106370010005	metal-binding site [ion binding]
106370010006	GTP binding site [chemical binding]; other site
106370010007	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
106370010008	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
106370010009	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
106370010010	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
106370010011	catalytic residues [active]
106370010012	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
106370010013	active site
106370010014	HIGH motif; other site
106370010015	nucleotide binding site [chemical binding]; other site
106370010016	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
106370010017	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
106370010018	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
106370010019	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
106370010020	active site
106370010021	KMSKS motif; other site
106370010022	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
106370010023	tRNA binding surface [nucleotide binding]; other site
106370010024	Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264
106370010025	mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446
106370010026	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
106370010027	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
106370010028	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
106370010029	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
106370010030	Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867
106370010031	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
106370010032	metal ion-dependent adhesion site (MIDAS); other site
106370010033	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
106370010034	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
106370010035	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
106370010036	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
106370010037	active site
106370010038	catalytic triad [active]
106370010039	oxyanion hole [active]
106370010040	Domain of unknown function (DUF4287); Region: DUF4287; pfam14117
106370010041	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
106370010042	Bax inhibitor 1 like; Region: BaxI_1; cl17691
106370010043	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
106370010044	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
106370010045	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
106370010046	Fe-S cluster binding site [ion binding]; other site
106370010047	DNA binding site [nucleotide binding]
106370010048	active site
106370010049	exopolyphosphatase; Region: exo_poly_only; TIGR03706
106370010050	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
106370010051	Protein of unknown function (DUF501); Region: DUF501; cl00652
106370010052	Septum formation initiator; Region: DivIC; pfam04977
106370010053	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
106370010054	enolase; Provisional; Region: eno; PRK00077
106370010055	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
106370010056	dimer interface [polypeptide binding]; other site
106370010057	metal binding site [ion binding]; metal-binding site
106370010058	substrate binding pocket [chemical binding]; other site
106370010059	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
106370010060	tandem repeat interface [polypeptide binding]; other site
106370010061	oligomer interface [polypeptide binding]; other site
106370010062	active site residues [active]
106370010063	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
106370010064	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
106370010065	tandem repeat interface [polypeptide binding]; other site
106370010066	oligomer interface [polypeptide binding]; other site
106370010067	active site residues [active]
106370010068	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
106370010069	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
106370010070	DNA binding residues [nucleotide binding]
106370010071	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
106370010072	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
106370010073	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
106370010074	ATP binding site [chemical binding]; other site
106370010075	putative Mg++ binding site [ion binding]; other site
106370010076	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
106370010077	nucleotide binding region [chemical binding]; other site
106370010078	ATP-binding site [chemical binding]; other site
106370010079	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
106370010080	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
106370010081	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
106370010082	homodimer interface [polypeptide binding]; other site
106370010083	metal binding site [ion binding]; metal-binding site
106370010084	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
106370010085	homodimer interface [polypeptide binding]; other site
106370010086	putative chemical substrate binding site [chemical binding]; other site
106370010087	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
106370010088	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
106370010089	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
106370010090	active site
106370010091	M28 Zn-Peptidases; Region: M28_like_3; cd05644
106370010092	Domain of unknown function (DUF2172); Region: DUF2172; pfam09940
106370010093	active site
106370010094	metal binding site [ion binding]; metal-binding site
106370010095	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
106370010096	substrate binding site; other site
106370010097	dimer interface; other site
106370010098	short chain dehydrogenase; Provisional; Region: PRK08219
106370010099	classical (c) SDRs; Region: SDR_c; cd05233
106370010100	NAD(P) binding site [chemical binding]; other site
106370010101	active site
106370010102	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
106370010103	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_11; cd13126
106370010104	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
106370010105	Methyltransferase domain; Region: Methyltransf_23; pfam13489
106370010106	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370010107	S-adenosylmethionine binding site [chemical binding]; other site
106370010108	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
106370010109	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
106370010110	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
106370010111	extended (e) SDRs; Region: SDR_e; cd08946
106370010112	NAD(P) binding site [chemical binding]; other site
106370010113	active site
106370010114	substrate binding site [chemical binding]; other site
106370010115	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
106370010116	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
106370010117	trimer interface [polypeptide binding]; other site
106370010118	active site
106370010119	substrate binding site [chemical binding]; other site
106370010120	CoA binding site [chemical binding]; other site
106370010121	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
106370010122	Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882
106370010123	Acid Phosphatase; Region: Acid_PPase; cl17256
106370010124	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
106370010125	active site
106370010126	catalytic residues [active]
106370010127	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
106370010128	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
106370010129	active site
106370010130	HIGH motif; other site
106370010131	dimer interface [polypeptide binding]; other site
106370010132	KMSKS motif; other site
106370010133	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
106370010134	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
106370010135	active site
106370010136	CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439
106370010137	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
106370010138	DXD motif; other site
106370010139	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
106370010140	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
106370010141	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
106370010142	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
106370010143	putative active site [active]
106370010144	catalytic residue [active]
106370010145	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
106370010146	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
106370010147	5S rRNA interface [nucleotide binding]; other site
106370010148	CTC domain interface [polypeptide binding]; other site
106370010149	L16 interface [polypeptide binding]; other site
106370010150	Asp23 family; Region: Asp23; pfam03780
106370010151	4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947
106370010152	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
106370010153	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
106370010154	ABC transporter; Region: ABC_tran_2; pfam12848
106370010155	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
106370010156	Fatty acid desaturase; Region: FA_desaturase; pfam00487
106370010157	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
106370010158	Di-iron ligands [ion binding]; other site
106370010159	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
106370010160	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
106370010161	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
106370010162	Substrate binding site; other site
106370010163	Mg++ binding site; other site
106370010164	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
106370010165	active site
106370010166	substrate binding site [chemical binding]; other site
106370010167	CoA binding site [chemical binding]; other site
106370010168	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
106370010169	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
106370010170	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
106370010171	active site
106370010172	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
106370010173	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
106370010174	active site
106370010175	HIGH motif; other site
106370010176	dimer interface [polypeptide binding]; other site
106370010177	KMSKS motif; other site
106370010178	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
106370010179	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
106370010180	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
106370010181	active site
106370010182	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
106370010183	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630
106370010184	putative active site [active]
106370010185	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
106370010186	Predicted methyltransferases [General function prediction only]; Region: COG0313
106370010187	putative SAM binding site [chemical binding]; other site
106370010188	putative homodimer interface [polypeptide binding]; other site
106370010189	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
106370010190	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
106370010191	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
106370010192	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
106370010193	phosphopeptide binding site; other site
106370010194	Domain of unknown function (DUF305); Region: DUF305; pfam03713
106370010195	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
106370010196	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
106370010197	Sulfate transporter family; Region: Sulfate_transp; pfam00916
106370010198	Sulfate transporter family; Region: Sulfate_transp; pfam00916
106370010199	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
106370010200	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
106370010201	active site
106370010202	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
106370010203	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
106370010204	active site
106370010205	metal binding site [ion binding]; metal-binding site
106370010206	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
106370010207	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
106370010208	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
106370010209	catalytic triad [active]
106370010210	dimer interface [polypeptide binding]; other site
106370010211	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
106370010212	putative substrate translocation pore; other site
106370010213	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
106370010214	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
106370010215	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
106370010216	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
106370010217	Protein kinase domain; Region: Pkinase; pfam00069
106370010218	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_30; cd04689
106370010219	nudix motif; other site
106370010220	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
106370010221	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
106370010222	DNA binding residues [nucleotide binding]
106370010223	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
106370010224	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
106370010225	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
106370010226	dimer interface [polypeptide binding]; other site
106370010227	conserved gate region; other site
106370010228	putative PBP binding loops; other site
106370010229	ABC-ATPase subunit interface; other site
106370010230	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
106370010231	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
106370010232	Walker A/P-loop; other site
106370010233	ATP binding site [chemical binding]; other site
106370010234	Q-loop/lid; other site
106370010235	ABC transporter signature motif; other site
106370010236	Walker B; other site
106370010237	D-loop; other site
106370010238	H-loop/switch region; other site
106370010239	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
106370010240	active site
106370010241	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
106370010242	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
106370010243	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
106370010244	catalytic residues [active]
106370010245	catalytic nucleophile [active]
106370010246	Presynaptic Site I dimer interface [polypeptide binding]; other site
106370010247	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
106370010248	Synaptic Flat tetramer interface [polypeptide binding]; other site
106370010249	Synaptic Site I dimer interface [polypeptide binding]; other site
106370010250	DNA binding site [nucleotide binding]
106370010251	Recombinase; Region: Recombinase; pfam07508
106370010252	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
106370010253	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
106370010254	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
106370010255	Flavoprotein; Region: Flavoprotein; cl08021
106370010256	thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891
106370010257	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
106370010258	active site
106370010259	zinc binding site [ion binding]; other site
106370010260	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
106370010261	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
106370010262	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
106370010263	conserved hypothetical protein; Region: TIGR03843
106370010264	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
106370010265	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
106370010266	Predicted transcriptional regulator [Transcription]; Region: COG1959
106370010267	Transcriptional regulator; Region: Rrf2; pfam02082
106370010268	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
106370010269	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
106370010270	putative substrate translocation pore; other site
106370010271	conserved hypothetical protein; Region: TIGR03843
106370010272	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
106370010273	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
106370010274	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
106370010275	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
106370010276	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
106370010277	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
106370010278	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
106370010279	Protein of unknown function DUF45; Region: DUF45; pfam01863
106370010280	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
106370010281	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
106370010282	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
106370010283	ATP binding site [chemical binding]; other site
106370010284	putative Mg++ binding site [ion binding]; other site
106370010285	EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737
106370010286	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
106370010287	DDE superfamily endonuclease; Region: DDE_5; cl17874
106370010288	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
106370010289	HsdM N-terminal domain; Region: HsdM_N; pfam12161
106370010290	Methyltransferase domain; Region: Methyltransf_26; pfam13659
106370010291	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
106370010292	ThiF family; Region: ThiF; pfam00899
106370010293	ATP binding site [chemical binding]; other site
106370010294	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
106370010295	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370010296	non-specific DNA binding site [nucleotide binding]; other site
106370010297	salt bridge; other site
106370010298	sequence-specific DNA binding site [nucleotide binding]; other site
106370010299	Domain of unknown function (DUF955); Region: DUF955; pfam06114
106370010300	Semenogelin; Region: Semenogelin; pfam05474
106370010301	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
106370010302	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
106370010303	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
106370010304	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
106370010305	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
106370010306	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
106370010307	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
106370010308	DNA binding residues [nucleotide binding]
106370010309	dimerization interface [polypeptide binding]; other site
106370010310	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
106370010311	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
106370010312	acyl-activating enzyme (AAE) consensus motif; other site
106370010313	AMP binding site [chemical binding]; other site
106370010314	active site
106370010315	CoA binding site [chemical binding]; other site
106370010316	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
106370010317	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
106370010318	DNA binding residues [nucleotide binding]
106370010319	dimerization interface [polypeptide binding]; other site
106370010320	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
106370010321	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
106370010322	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
106370010323	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
106370010324	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
106370010325	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
106370010326	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
106370010327	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
106370010328	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
106370010329	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
106370010330	MPT binding site; other site
106370010331	trimer interface [polypeptide binding]; other site
106370010332	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
106370010333	trimer interface [polypeptide binding]; other site
106370010334	dimer interface [polypeptide binding]; other site
106370010335	putative active site [active]
106370010336	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
106370010337	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
106370010338	dimer interface [polypeptide binding]; other site
106370010339	putative functional site; other site
106370010340	putative MPT binding site; other site
106370010341	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
106370010342	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
106370010343	active site
106370010344	tetramer interface; other site
106370010345	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
106370010346	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
106370010347	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
106370010348	putative homodimer interface [polypeptide binding]; other site
106370010349	putative homotetramer interface [polypeptide binding]; other site
106370010350	putative allosteric switch controlling residues; other site
106370010351	putative metal binding site [ion binding]; other site
106370010352	putative homodimer-homodimer interface [polypeptide binding]; other site
106370010353	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; cl17321
106370010354	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
106370010355	substrate binding site [chemical binding]; other site
106370010356	activation loop (A-loop); other site
106370010357	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
106370010358	structural tetrad; other site
106370010359	FOG: WD40 repeat [General function prediction only]; Region: COG2319
106370010360	Response regulator receiver domain; Region: Response_reg; pfam00072
106370010361	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
106370010362	active site
106370010363	phosphorylation site [posttranslational modification]
106370010364	intermolecular recognition site; other site
106370010365	dimerization interface [polypeptide binding]; other site
106370010366	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
106370010367	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
106370010368	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
106370010369	dimerization interface [polypeptide binding]; other site
106370010370	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
106370010371	dimerization interface [polypeptide binding]; other site
106370010372	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
106370010373	dimerization interface [polypeptide binding]; other site
106370010374	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
106370010375	dimerization interface [polypeptide binding]; other site
106370010376	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
106370010377	dimerization interface [polypeptide binding]; other site
106370010378	GAF domain; Region: GAF_2; pfam13185
106370010379	GAF domain; Region: GAF; pfam01590
106370010380	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
106370010381	dimer interface [polypeptide binding]; other site
106370010382	phosphorylation site [posttranslational modification]
106370010383	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
106370010384	ATP binding site [chemical binding]; other site
106370010385	Mg2+ binding site [ion binding]; other site
106370010386	G-X-G motif; other site
106370010387	Response regulator receiver domain; Region: Response_reg; pfam00072
106370010388	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
106370010389	active site
106370010390	phosphorylation site [posttranslational modification]
106370010391	intermolecular recognition site; other site
106370010392	dimerization interface [polypeptide binding]; other site
106370010393	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
106370010394	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
106370010395	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
106370010396	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
106370010397	catalytic residue [active]
106370010398	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
106370010399	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938
106370010400	inhibitor-cofactor binding pocket; inhibition site
106370010401	pyridoxal 5'-phosphate binding site [chemical binding]; other site
106370010402	catalytic residue [active]
106370010403	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
106370010404	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
106370010405	catalytic residue [active]
106370010406	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
106370010407	IucA / IucC family; Region: IucA_IucC; pfam04183
106370010408	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
106370010409	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
106370010410	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
106370010411	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
106370010412	IucA / IucC family; Region: IucA_IucC; pfam04183
106370010413	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
106370010414	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
106370010415	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
106370010416	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
106370010417	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
106370010418	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
106370010419	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
106370010420	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
106370010421	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
106370010422	metal binding site [ion binding]; metal-binding site
106370010423	active site
106370010424	I-site; other site
106370010425	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
106370010426	glycine dehydrogenase; Provisional; Region: PRK05367
106370010427	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
106370010428	tetramer interface [polypeptide binding]; other site
106370010429	pyridoxal 5'-phosphate binding site [chemical binding]; other site
106370010430	catalytic residue [active]
106370010431	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
106370010432	pyridoxal 5'-phosphate binding site [chemical binding]; other site
106370010433	tetramer interface [polypeptide binding]; other site
106370010434	catalytic residue [active]
106370010435	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
106370010436	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
106370010437	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
106370010438	MoxR-like ATPases [General function prediction only]; Region: COG0714
106370010439	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
106370010440	ATP binding site [chemical binding]; other site
106370010441	Walker A motif; other site
106370010442	Walker B motif; other site
106370010443	arginine finger; other site
106370010444	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
106370010445	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
106370010446	MMPL family; Region: MMPL; pfam03176
106370010447	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
106370010448	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
106370010449	Integrase core domain; Region: rve; pfam00665
106370010450	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
106370010451	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
106370010452	active site
106370010453	PHP Thumb interface [polypeptide binding]; other site
106370010454	metal binding site [ion binding]; metal-binding site
106370010455	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
106370010456	generic binding surface I; other site
106370010457	generic binding surface II; other site
106370010458	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
106370010459	Integrase core domain; Region: rve; pfam00665
106370010460	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
106370010461	Resolvase, N terminal domain; Region: Resolvase; smart00857
106370010462	catalytic nucleophile [active]
106370010463	Recombinase; Region: Recombinase; pfam07508
106370010464	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
106370010465	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
106370010466	aromatic arch; other site
106370010467	DCoH dimer interaction site [polypeptide binding]; other site
106370010468	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
106370010469	DCoH tetramer interaction site [polypeptide binding]; other site
106370010470	substrate binding site [chemical binding]; other site
106370010471	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370010472	non-specific DNA binding site [nucleotide binding]; other site
106370010473	salt bridge; other site
106370010474	sequence-specific DNA binding site [nucleotide binding]; other site
106370010475	S-adenosyl-L-homocysteine hydrolase, NAD binding domain; Region: AdoHcyase_NAD; smart00997
106370010476	NAD binding site [chemical binding]; other site
106370010477	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
106370010478	nudix motif; other site
106370010479	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
106370010480	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
106370010481	Integrase core domain; Region: rve; pfam00665
106370010482	DDE domain; Region: DDE_Tnp_IS240; pfam13610
106370010483	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
106370010484	N-terminal and C-terminal aromatase/cyclase domains of Streptomyces rimosus  OtcD1 and related domains; Region: OtcD1_ARO-CYC_like; cd08861
106370010485	putative hydrophobic ligand binding site [chemical binding]; other site
106370010486	N-terminal and C-terminal aromatase/cyclase domains of Streptomyces rimosus  OtcD1 and related domains; Region: OtcD1_ARO-CYC_like; cd08861
106370010487	putative hydrophobic ligand binding site [chemical binding]; other site
106370010488	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
106370010489	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
106370010490	Chain-length factor (CLF) is a factor required for polyketide chain initiation of aromatic antibiotic-producing polyketide synthases (PKSs) of filamentous bacteria. CLFs have been shown to have decarboxylase activity towards malonyl-acyl carrier protein; Region: CLF; cd00832
106370010491	active site
106370010492	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
106370010493	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
106370010494	dimer interface [polypeptide binding]; other site
106370010495	active site
106370010496	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
106370010497	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
106370010498	active site
106370010499	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
106370010500	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
106370010501	NAD(P) binding site [chemical binding]; other site
106370010502	active site
106370010503	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
106370010504	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
106370010505	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
106370010506	putative NAD(P) binding site [chemical binding]; other site
106370010507	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
106370010508	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
106370010509	catalytic residues [active]
106370010510	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
106370010511	Integrase core domain; Region: rve; pfam00665
106370010512	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
106370010513	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
106370010514	oligomeric interface; other site
106370010515	putative active site [active]
106370010516	homodimer interface [polypeptide binding]; other site
106370010517	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
106370010518	Integrase core domain; Region: rve; pfam00665
106370010519	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
106370010520	Cytochrome P450; Region: p450; cl12078
106370010521	DDE superfamily endonuclease; Region: DDE_3; pfam13358
106370010522	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
106370010523	Winged helix-turn helix; Region: HTH_29; pfam13551
106370010524	Winged helix-turn helix; Region: HTH_33; pfam13592
106370010525	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
106370010526	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
106370010527	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
106370010528	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
106370010529	23S rRNA interface [nucleotide binding]; other site
106370010530	L7/L12 interface [polypeptide binding]; other site
106370010531	putative thiostrepton binding site; other site
106370010532	L25 interface [polypeptide binding]; other site
106370010533	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
106370010534	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
106370010535	Transposase, Mutator family; Region: Transposase_mut; pfam00872
106370010536	Transposase; Region: DEDD_Tnp_IS110; pfam01548
106370010537	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
106370010538	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
106370010539	Resolvase, N terminal domain; Region: Resolvase; smart00857
106370010540	Recombinase; Region: Recombinase; pfam07508
106370010541	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
106370010542	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
106370010543	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370010544	non-specific DNA binding site [nucleotide binding]; other site
106370010545	salt bridge; other site
106370010546	sequence-specific DNA binding site [nucleotide binding]; other site
106370010547	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
106370010548	NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559
106370010549	NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559
106370010550	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370010551	S-adenosylmethionine binding site [chemical binding]; other site
106370010552	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
106370010553	short chain dehydrogenase; Provisional; Region: PRK08263
106370010554	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
106370010555	NADP binding site [chemical binding]; other site
106370010556	active site
106370010557	steroid binding site; other site
106370010558	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
106370010559	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
106370010560	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
106370010561	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
106370010562	SnoaL-like domain; Region: SnoaL_4; pfam13577
106370010563	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
106370010564	active site
106370010565	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
106370010566	N-terminal and C-terminal aromatase/cyclase domains of Streptomyces rimosus  OtcD1 and related domains; Region: OtcD1_ARO-CYC_like; cd08861
106370010567	putative hydrophobic ligand binding site [chemical binding]; other site
106370010568	N-terminal and C-terminal aromatase/cyclase domains of Streptomyces rimosus  OtcD1 and related domains; Region: OtcD1_ARO-CYC_like; cd08861
106370010569	putative hydrophobic ligand binding site [chemical binding]; other site
106370010570	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
106370010571	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
106370010572	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
106370010573	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
106370010574	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
106370010575	NAD(P) binding site [chemical binding]; other site
106370010576	active site
106370010577	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
106370010578	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
106370010579	active site
106370010580	Integrase core domain; Region: rve; pfam00665
106370010581	DDE domain; Region: DDE_Tnp_IS240; pfam13610
106370010582	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
106370010583	Protein of unknown function (DUF1205); Region: DUF1205; pfam06722
106370010584	N-terminal and C-terminal aromatase/cyclase domains of Streptomyces rimosus  OtcD1 and related domains; Region: OtcD1_ARO-CYC_like; cd08861
106370010585	putative hydrophobic ligand binding site [chemical binding]; other site
106370010586	N-terminal and C-terminal aromatase/cyclase domains of Streptomyces rimosus  OtcD1 and related domains; Region: OtcD1_ARO-CYC_like; cd08861
106370010587	putative hydrophobic ligand binding site [chemical binding]; other site
106370010588	Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563
106370010589	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
106370010590	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
106370010591	NAD(P) binding site [chemical binding]; other site
106370010592	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
106370010593	Major Facilitator Superfamily; Region: MFS_1; pfam07690
106370010594	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
106370010595	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
106370010596	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
106370010597	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
106370010598	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
106370010599	non-specific DNA binding site [nucleotide binding]; other site
106370010600	salt bridge; other site
106370010601	sequence-specific DNA binding site [nucleotide binding]; other site
106370010602	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
106370010603	catalytic residues [active]
106370010604	catalytic nucleophile [active]
106370010605	Recombinase; Region: Recombinase; pfam07508
106370010606	Predicted flavoprotein [General function prediction only]; Region: COG0431
106370010607	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
106370010608	Integrase core domain; Region: rve; pfam00665
106370010609	DDE domain; Region: DDE_Tnp_IS240; pfam13610
106370010610	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
106370010611	Integrase core domain; Region: rve; pfam00665
106370010612	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
106370010613	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
106370010614	active site
106370010615	PHP Thumb interface [polypeptide binding]; other site
106370010616	metal binding site [ion binding]; metal-binding site
106370010617	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
106370010618	generic binding surface I; other site
106370010619	generic binding surface II; other site
106370010620	Integrase core domain; Region: rve; pfam00665
106370010621	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
106370010622	dinuclear metal binding motif [ion binding]; other site
106370010623	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
106370010624	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
106370010625	CoenzymeA binding site [chemical binding]; other site
106370010626	subunit interaction site [polypeptide binding]; other site
106370010627	PHB binding site; other site
106370010628	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
106370010629	dinuclear metal binding motif [ion binding]; other site
106370010630	CopC domain; Region: CopC; pfam04234
106370010631	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
106370010632	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
106370010633	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705
106370010634	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
106370010635	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
106370010636	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
106370010637	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
106370010638	PAS domain S-box; Region: sensory_box; TIGR00229
106370010639	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
106370010640	putative active site [active]
106370010641	heme pocket [chemical binding]; other site
106370010642	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
106370010643	histidine kinase; Provisional; Region: PRK13557
106370010644	putative active site [active]
106370010645	heme pocket [chemical binding]; other site
106370010646	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
106370010647	dimer interface [polypeptide binding]; other site
106370010648	phosphorylation site [posttranslational modification]
106370010649	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
106370010650	ATP binding site [chemical binding]; other site
106370010651	Mg2+ binding site [ion binding]; other site
106370010652	G-X-G motif; other site
106370010653	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
106370010654	active site
106370010655	phosphorylation site [posttranslational modification]
106370010656	intermolecular recognition site; other site
106370010657	dimerization interface [polypeptide binding]; other site
106370010658	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
106370010659	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
106370010660	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
106370010661	DNA binding residues [nucleotide binding]
106370010662	WD40 repeats; Region: WD40; smart00320
106370010663	FOG: WD40 repeat [General function prediction only]; Region: COG2319
106370010664	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
106370010665	structural tetrad; other site
106370010666	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
106370010667	structural tetrad; other site
106370010668	FOG: WD40 repeat [General function prediction only]; Region: COG2319
106370010669	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
106370010670	Catalytic domain of Protein Kinases; Region: PKc; cd00180
106370010671	active site
106370010672	ATP binding site [chemical binding]; other site
106370010673	substrate binding site [chemical binding]; other site
106370010674	activation loop (A-loop); other site
106370010675	NHL repeat; Region: NHL; pfam01436
106370010676	TIR domain; Region: TIR_2; pfam13676
106370010677	Tetratricopeptide repeat; Region: TPR_12; pfam13424
106370010678	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
106370010679	binding surface
106370010680	TPR motif; other site
106370010681	Tetratricopeptide repeat; Region: TPR_12; pfam13424
106370010682	Tetratricopeptide repeat; Region: TPR_12; pfam13424
106370010683	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
106370010684	binding surface
106370010685	TPR motif; other site
106370010686	Tetratricopeptide repeat; Region: TPR_12; pfam13424
106370010687	Tetratricopeptide repeat; Region: TPR_12; pfam13424
106370010688	biotin synthase; Validated; Region: PRK06256
106370010689	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
106370010690	FeS/SAM binding site; other site
106370010691	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
106370010692	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
106370010693	active site
106370010694	metal binding site [ion binding]; metal-binding site
106370010695	nudix motif; other site
106370010696	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
106370010697	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
106370010698	Transposase; Region: DDE_Tnp_ISL3; pfam01610
106370010699	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
106370010700	Transposase; Region: DDE_Tnp_ISL3; pfam01610
106370010701	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370010702	S-adenosylmethionine binding site [chemical binding]; other site
106370010703	Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738
106370010704	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
106370010705	YcaO-like family; Region: YcaO; pfam02624
106370010706	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
106370010707	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
106370010708	FMN binding site [chemical binding]; other site
106370010709	dimer interface [polypeptide binding]; other site
106370010710	SpaB C-terminal domain; Region: SpaB_C; pfam14028
106370010711	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
106370010712	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
106370010713	Walker A/P-loop; other site
106370010714	ATP binding site [chemical binding]; other site
106370010715	Q-loop/lid; other site
106370010716	ABC transporter signature motif; other site
106370010717	Walker B; other site
106370010718	D-loop; other site
106370010719	H-loop/switch region; other site
106370010720	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
106370010721	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
106370010722	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
106370010723	acyl-CoA synthetase; Validated; Region: PRK06188
106370010724	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
106370010725	acyl-activating enzyme (AAE) consensus motif; other site
106370010726	AMP binding site [chemical binding]; other site
106370010727	active site
106370010728	CoA binding site [chemical binding]; other site
106370010729	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
106370010730	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
106370010731	putative active site; other site
106370010732	catalytic residue [active]
106370010733	Predicted alternative 3-dehydroquinate synthase [Amino acid transport and metabolism]; Region: COG1465
106370010734	3-dehydroquinate synthase; Provisional; Region: PRK02290
106370010735	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
106370010736	salicylate hydroxylase; Provisional; Region: PRK08163
106370010737	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
106370010738	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
106370010739	DNA binding residues [nucleotide binding]
106370010740	dimerization interface [polypeptide binding]; other site
106370010741	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
106370010742	Helix-turn-helix domain; Region: HTH_38; pfam13936
106370010743	Integrase core domain; Region: rve; pfam00665
106370010744	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
106370010745	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
106370010746	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
106370010747	Transposase; Region: DDE_Tnp_ISL3; pfam01610
106370010748	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
106370010749	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
106370010750	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
106370010751	Transposase; Region: DEDD_Tnp_IS110; pfam01548
106370010752	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
106370010753	DDE superfamily endonuclease; Region: DDE_4; pfam13359
106370010754	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
106370010755	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
106370010756	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
106370010757	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
106370010758	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
106370010759	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
106370010760	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
106370010761	Transposase; Region: DDE_Tnp_ISL3; pfam01610
106370010762	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
106370010763	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
106370010764	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
106370010765	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
106370010766	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
106370010767	Hemerythrin-like domain; Region: Hr-like; cd12108
106370010768	Fe binding site [ion binding]; other site
106370010769	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
106370010770	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
106370010771	ligand binding site [chemical binding]; other site
106370010772	flexible hinge region; other site
106370010773	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
106370010774	substrate binding pocket [chemical binding]; other site
106370010775	substrate-Mg2+ binding site; other site
106370010776	aspartate-rich region 1; other site
106370010777	aspartate-rich region 2; other site
106370010778	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
106370010779	substrate binding pocket [chemical binding]; other site
106370010780	substrate-Mg2+ binding site; other site
106370010781	aspartate-rich region 1; other site
106370010782	aspartate-rich region 2; other site
106370010783	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
106370010784	putative FMN binding site [chemical binding]; other site
106370010785	NADPH bind site [chemical binding]; other site
106370010786	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
106370010787	YcaO-like family; Region: YcaO; pfam02624
106370010788	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
106370010789	YcaO-like family; Region: YcaO; pfam02624
106370010790	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
106370010791	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
106370010792	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
106370010793	H+ Antiporter protein; Region: 2A0121; TIGR00900
106370010794	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
106370010795	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
106370010796	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
106370010797	intersubunit interface [polypeptide binding]; other site
106370010798	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
106370010799	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
106370010800	Walker A/P-loop; other site
106370010801	ATP binding site [chemical binding]; other site
106370010802	Q-loop/lid; other site
106370010803	ABC transporter signature motif; other site
106370010804	Walker B; other site
106370010805	D-loop; other site
106370010806	H-loop/switch region; other site
106370010807	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
106370010808	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
106370010809	dimer interface [polypeptide binding]; other site
106370010810	putative PBP binding regions; other site
106370010811	ABC-ATPase subunit  interface; other site
106370010812	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
106370010813	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
106370010814	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
106370010815	Walker A/P-loop; other site
106370010816	ATP binding site [chemical binding]; other site
106370010817	Q-loop/lid; other site
106370010818	ABC transporter signature motif; other site
106370010819	Walker B; other site
106370010820	D-loop; other site
106370010821	H-loop/switch region; other site
106370010822	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
106370010823	Lipase (class 2); Region: Lipase_2; pfam01674
106370010824	Polypeptide deformylase; Region: Pep_deformylase; pfam01327
106370010825	active site
106370010826	catalytic residues [active]
106370010827	metal binding site [ion binding]; metal-binding site
106370010828	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
106370010829	N-acetyl-D-glucosamine binding site [chemical binding]; other site
106370010830	catalytic residue [active]
106370010831	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
106370010832	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
106370010833	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
106370010834	Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
106370010835	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
106370010836	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
106370010837	phosphopeptide binding site; other site
106370010838	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
106370010839	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
106370010840	active site
106370010841	HIGH motif; other site
106370010842	nucleotide binding site [chemical binding]; other site
106370010843	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
106370010844	KMSKS motif; other site
106370010845	This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840
106370010846	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
106370010847	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
106370010848	homotrimer interaction site [polypeptide binding]; other site
106370010849	zinc binding site [ion binding]; other site
106370010850	CDP-binding sites; other site
106370010851	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
106370010852	substrate binding site; other site
106370010853	dimer interface; other site
106370010854	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
106370010855	Protein of unknown function (DUF461); Region: DUF461; pfam04314
106370010856	DNA repair protein RadA; Provisional; Region: PRK11823
106370010857	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
106370010858	Walker A motif; other site
106370010859	ATP binding site [chemical binding]; other site
106370010860	Walker B motif; other site
106370010861	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
106370010862	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
106370010863	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
106370010864	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
106370010865	endonuclease III; Region: ENDO3c; smart00478
106370010866	minor groove reading motif; other site
106370010867	helix-hairpin-helix signature motif; other site
106370010868	substrate binding pocket [chemical binding]; other site
106370010869	active site
106370010870	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
106370010871	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
106370010872	DNA binding site [nucleotide binding]
106370010873	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
106370010874	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
106370010875	Walker A/P-loop; other site
106370010876	ATP binding site [chemical binding]; other site
106370010877	Q-loop/lid; other site
106370010878	ABC transporter signature motif; other site
106370010879	Walker B; other site
106370010880	D-loop; other site
106370010881	H-loop/switch region; other site
106370010882	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
106370010883	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
106370010884	dimer interface [polypeptide binding]; other site
106370010885	conserved gate region; other site
106370010886	putative PBP binding loops; other site
106370010887	ABC-ATPase subunit interface; other site
106370010888	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
106370010889	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
106370010890	dimer interface [polypeptide binding]; other site
106370010891	conserved gate region; other site
106370010892	putative PBP binding loops; other site
106370010893	ABC-ATPase subunit interface; other site
106370010894	PBP superfamily domain; Region: PBP_like_2; cl17296
106370010895	Frankia-40 domain; Region: Frankia_40_dom; TIGR03917
106370010896	prolyl-tRNA synthetase; Provisional; Region: PRK08661
106370010897	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
106370010898	dimer interface [polypeptide binding]; other site
106370010899	motif 1; other site
106370010900	active site
106370010901	motif 2; other site
106370010902	motif 3; other site
106370010903	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
106370010904	anticodon binding site; other site
106370010905	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
106370010906	putative nucleotide binding site [chemical binding]; other site
106370010907	uridine monophosphate binding site [chemical binding]; other site
106370010908	homohexameric interface [polypeptide binding]; other site
106370010909	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
106370010910	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
106370010911	putative ligand binding site [chemical binding]; other site
106370010912	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
106370010913	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
106370010914	DNA-binding site [nucleotide binding]; DNA binding site
106370010915	UTRA domain; Region: UTRA; pfam07702
106370010916	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
106370010917	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
106370010918	active site
106370010919	DNA binding site [nucleotide binding]
106370010920	Int/Topo IB signature motif; other site
106370010921	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
106370010922	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
106370010923	putative active site [active]
106370010924	putative metal binding site [ion binding]; other site
106370010925	Yqey-like protein; Region: YqeY; cl17540
106370010926	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
106370010927	Transglycosylase; Region: Transgly; pfam00912
106370010928	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
106370010929	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
106370010930	Transcription factor WhiB; Region: Whib; pfam02467
106370010931	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
106370010932	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
106370010933	P loop; other site
106370010934	Nucleotide binding site [chemical binding]; other site
106370010935	DTAP/Switch II; other site
106370010936	Switch I; other site
106370010937	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
106370010938	DTAP/Switch II; other site
106370010939	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
106370010940	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
106370010941	homotrimer interaction site [polypeptide binding]; other site
106370010942	putative active site [active]
106370010943	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
106370010944	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
106370010945	cyclase homology domain; Region: CHD; cd07302
106370010946	nucleotidyl binding site; other site
106370010947	metal binding site [ion binding]; metal-binding site
106370010948	dimer interface [polypeptide binding]; other site
106370010949	AAA ATPase domain; Region: AAA_16; pfam13191
106370010950	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
106370010951	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
106370010952	TPR motif; other site
106370010953	binding surface
106370010954	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
106370010955	TPR motif; other site
106370010956	binding surface
106370010957	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
106370010958	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
106370010959	ligand binding site [chemical binding]; other site
106370010960	flexible hinge region; other site
106370010961	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
106370010962	putative switch regulator; other site
106370010963	non-specific DNA interactions [nucleotide binding]; other site
106370010964	DNA binding site [nucleotide binding]
106370010965	sequence specific DNA binding site [nucleotide binding]; other site
106370010966	putative cAMP binding site [chemical binding]; other site
106370010967	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
106370010968	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
106370010969	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
106370010970	helix-hairpin-helix signature motif; other site
106370010971	substrate binding pocket [chemical binding]; other site
106370010972	active site
106370010973	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
106370010974	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
106370010975	putative active site [active]
106370010976	putative CoA binding site [chemical binding]; other site
106370010977	nudix motif; other site
106370010978	metal binding site [ion binding]; metal-binding site
106370010979	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
106370010980	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
106370010981	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
106370010982	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
106370010983	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
106370010984	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
106370010985	helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
106370010986	Type II/IV secretion system protein; Region: T2SE; pfam00437
106370010987	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
106370010988	ATP binding site [chemical binding]; other site
106370010989	Walker A motif; other site
106370010990	hexamer interface [polypeptide binding]; other site
106370010991	Walker B motif; other site
106370010992	helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816
106370010993	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
106370010994	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
106370010995	ATP binding site [chemical binding]; other site
106370010996	putative Mg++ binding site [ion binding]; other site
106370010997	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
106370010998	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
106370010999	anti sigma factor interaction site; other site
106370011000	regulatory phosphorylation site [posttranslational modification]; other site
106370011001	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
106370011002	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
106370011003	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
106370011004	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
106370011005	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
106370011006	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
106370011007	active site
106370011008	interdomain interaction site; other site
106370011009	putative metal-binding site [ion binding]; other site
106370011010	nucleotide binding site [chemical binding]; other site
106370011011	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
106370011012	domain I; other site
106370011013	phosphate binding site [ion binding]; other site
106370011014	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
106370011015	domain II; other site
106370011016	domain III; other site
106370011017	nucleotide binding site [chemical binding]; other site
106370011018	DNA binding groove [nucleotide binding]
106370011019	catalytic site [active]
106370011020	domain IV; other site
106370011021	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
106370011022	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
106370011023	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
106370011024	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
106370011025	Transmembrane secretion effector; Region: MFS_3; pfam05977
106370011026	thymidylate kinase; Validated; Region: tmk; PRK00698
106370011027	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
106370011028	TMP-binding site; other site
106370011029	ATP-binding site [chemical binding]; other site
106370011030	DNA polymerase III subunit delta'; Validated; Region: PRK07940
106370011031	PSP1 C-terminal conserved region; Region: PSP1; cl00770
106370011032	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
106370011033	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
106370011034	active site
106370011035	phosphorylation site [posttranslational modification]
106370011036	intermolecular recognition site; other site
106370011037	dimerization interface [polypeptide binding]; other site
106370011038	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
106370011039	DNA binding site [nucleotide binding]
106370011040	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
106370011041	dimer interface [polypeptide binding]; other site
106370011042	substrate binding site [chemical binding]; other site
106370011043	metal binding sites [ion binding]; metal-binding site
106370011044	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
106370011045	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
106370011046	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
106370011047	Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103
106370011048	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
106370011049	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
106370011050	Ligand Binding Site [chemical binding]; other site
106370011051	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
106370011052	active site
106370011053	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
106370011054	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
106370011055	Walker A motif; other site
106370011056	ATP binding site [chemical binding]; other site
106370011057	Walker B motif; other site
106370011058	arginine finger; other site
106370011059	Peptidase family M41; Region: Peptidase_M41; pfam01434
106370011060	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
106370011061	homodecamer interface [polypeptide binding]; other site
106370011062	GTP cyclohydrolase I; Provisional; Region: PLN03044
106370011063	active site
106370011064	putative catalytic site residues [active]
106370011065	zinc binding site [ion binding]; other site
106370011066	GTP-CH-I/GFRP interaction surface; other site
106370011067	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
106370011068	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
106370011069	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
106370011070	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
106370011071	metal binding site [ion binding]; metal-binding site
106370011072	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
106370011073	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
106370011074	active site
106370011075	motif I; other site
106370011076	motif II; other site
106370011077	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
106370011078	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
106370011079	Protein of unknown function (DUF2587); Region: DUF2587; pfam10759
106370011080	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
106370011081	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
106370011082	NAD(P) binding site [chemical binding]; other site
106370011083	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
106370011084	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
106370011085	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
106370011086	DNA binding residues [nucleotide binding]
106370011087	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
106370011088	sensor protein QseC; Provisional; Region: PRK10337
106370011089	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
106370011090	ATP binding site [chemical binding]; other site
106370011091	Mg2+ binding site [ion binding]; other site
106370011092	G-X-G motif; other site
106370011093	Roadblock/LC7 domain; Region: Robl_LC7; smart00960
106370011094	Protein of unknown function (DUF742); Region: DUF742; pfam05331
106370011095	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
106370011096	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
106370011097	G2 box; other site
106370011098	Switch I region; other site
106370011099	G3 box; other site
106370011100	Switch II region; other site
106370011101	GTP/Mg2+ binding site [chemical binding]; other site
106370011102	G4 box; other site
106370011103	G5 box; other site
106370011104	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
106370011105	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
106370011106	substrate binding pocket [chemical binding]; other site
106370011107	substrate-Mg2+ binding site; other site
106370011108	aspartate-rich region 1; other site
106370011109	aspartate-rich region 2; other site
106370011110	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
106370011111	oligomeric interface; other site
106370011112	putative active site [active]
106370011113	homodimer interface [polypeptide binding]; other site
106370011114	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
106370011115	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
106370011116	DNA binding site [nucleotide binding]
106370011117	active site
106370011118	Int/Topo IB signature motif; other site
106370011119	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
106370011120	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
106370011121	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
106370011122	Walker A/P-loop; other site
106370011123	ATP binding site [chemical binding]; other site
106370011124	Q-loop/lid; other site
106370011125	ABC transporter signature motif; other site
106370011126	Walker B; other site
106370011127	D-loop; other site
106370011128	H-loop/switch region; other site
106370011129	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
106370011130	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
106370011131	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
106370011132	putative active site [active]
106370011133	putative dimer interface [polypeptide binding]; other site
106370011134	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
106370011135	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
106370011136	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
106370011137	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
106370011138	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
106370011139	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
106370011140	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
106370011141	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
106370011142	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
106370011143	motif II; other site
106370011144	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
106370011145	trimer interface [polypeptide binding]; other site
106370011146	active site
106370011147	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
106370011148	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
106370011149	4Fe-4S binding domain; Region: Fer4; pfam00037
106370011150	Cysteine-rich domain; Region: CCG; pfam02754
106370011151	Cysteine-rich domain; Region: CCG; pfam02754
106370011152	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
106370011153	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
106370011154	nucleotide binding site [chemical binding]; other site
106370011155	NEF interaction site [polypeptide binding]; other site
106370011156	SBD interface [polypeptide binding]; other site
106370011157	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
106370011158	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
106370011159	dimer interface [polypeptide binding]; other site
106370011160	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
106370011161	chaperone protein DnaJ; Provisional; Region: PRK14295
106370011162	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
106370011163	HSP70 interaction site [polypeptide binding]; other site
106370011164	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
106370011165	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
106370011166	dimer interface [polypeptide binding]; other site
106370011167	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
106370011168	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
106370011169	DNA binding residues [nucleotide binding]
106370011170	putative dimer interface [polypeptide binding]; other site
106370011171	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
106370011172	Clp amino terminal domain; Region: Clp_N; pfam02861
106370011173	Clp amino terminal domain; Region: Clp_N; pfam02861
106370011174	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
106370011175	Walker A motif; other site
106370011176	ATP binding site [chemical binding]; other site
106370011177	Walker B motif; other site
106370011178	arginine finger; other site
106370011179	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
106370011180	Walker A motif; other site
106370011181	ATP binding site [chemical binding]; other site
106370011182	Walker B motif; other site
106370011183	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
106370011184	Uncharacterized conserved protein [Function unknown]; Region: COG3402
106370011185	Predicted membrane protein [Function unknown]; Region: COG3428
106370011186	Bacterial PH domain; Region: DUF304; pfam03703
106370011187	Bacterial PH domain; Region: DUF304; pfam03703
106370011188	Bacterial PH domain; Region: DUF304; pfam03703
106370011189	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
106370011190	active site
106370011191	NTP binding site [chemical binding]; other site
106370011192	metal binding triad [ion binding]; metal-binding site
106370011193	GDP-D-mannose-3',5'-epimerase; Region: PLN02695
106370011194	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
106370011195	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
106370011196	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
106370011197	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
106370011198	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
106370011199	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
106370011200	active site
106370011201	intersubunit interface [polypeptide binding]; other site
106370011202	zinc binding site [ion binding]; other site
106370011203	Na+ binding site [ion binding]; other site
106370011204	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
106370011205	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
106370011206	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
106370011207	Protein of unknown function (DUF3151); Region: DUF3151; pfam11349
106370011208	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
106370011209	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
106370011210	GDP-binding site [chemical binding]; other site
106370011211	ACT binding site; other site
106370011212	IMP binding site; other site
106370011213	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
106370011214	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
106370011215	ATP-grasp domain; Region: ATP-grasp_4; cl17255
106370011216	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
106370011217	AIR carboxylase; Region: AIRC; pfam00731
106370011218	adenylosuccinate lyase; Provisional; Region: PRK07492
106370011219	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
106370011220	tetramer interface [polypeptide binding]; other site
106370011221	active site
106370011222	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
106370011223	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
106370011224	ATP binding site [chemical binding]; other site
106370011225	active site
106370011226	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
106370011227	substrate binding site [chemical binding]; other site
106370011228	pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380
106370011229	pantoate--beta-alanine ligase; Region: panC; TIGR00018
106370011230	active site
106370011231	nucleotide binding site [chemical binding]; other site
106370011232	HIGH motif; other site
106370011233	KMSKS motif; other site
106370011234	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
106370011235	tetramerization interface [polypeptide binding]; other site
106370011236	active site
106370011237	L-aspartate oxidase; Provisional; Region: PRK07804
106370011238	L-aspartate oxidase; Provisional; Region: PRK06175
106370011239	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
106370011240	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896
106370011241	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
106370011242	dimerization interface [polypeptide binding]; other site
106370011243	active site
106370011244	pantothenate kinase; Reviewed; Region: PRK13318
106370011245	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
106370011246	active site
106370011247	catalytic triad [active]
106370011248	oxyanion hole [active]
106370011249	siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951
106370011250	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
106370011251	Clp protease ATP binding subunit; Region: clpC; CHL00095
106370011252	Clp amino terminal domain; Region: Clp_N; pfam02861
106370011253	Clp amino terminal domain; Region: Clp_N; pfam02861
106370011254	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
106370011255	Walker A motif; other site
106370011256	ATP binding site [chemical binding]; other site
106370011257	Walker B motif; other site
106370011258	arginine finger; other site
106370011259	UvrB/uvrC motif; Region: UVR; pfam02151
106370011260	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
106370011261	Walker A motif; other site
106370011262	ATP binding site [chemical binding]; other site
106370011263	Walker B motif; other site
106370011264	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
106370011265	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
106370011266	active site
106370011267	metal binding site [ion binding]; metal-binding site
106370011268	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
106370011269	active site
106370011270	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
106370011271	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
106370011272	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
106370011273	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
106370011274	NAD(P) binding site [chemical binding]; other site
106370011275	RNHCP domain; Region: RNHCP; pfam12647
106370011276	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
106370011277	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
106370011278	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
106370011279	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
106370011280	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
106370011281	active site
106370011282	homotetramer interface [polypeptide binding]; other site
106370011283	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
106370011284	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
106370011285	active site
106370011286	motif I; other site
106370011287	motif II; other site
106370011288	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
106370011289	threonine synthase; Validated; Region: PRK07591
106370011290	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
106370011291	homodimer interface [polypeptide binding]; other site
106370011292	pyridoxal 5'-phosphate binding site [chemical binding]; other site
106370011293	catalytic residue [active]
106370011294	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
106370011295	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
106370011296	ring oligomerisation interface [polypeptide binding]; other site
106370011297	ATP/Mg binding site [chemical binding]; other site
106370011298	stacking interactions; other site
106370011299	hinge regions; other site
106370011300	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
106370011301	putative active site [active]
106370011302	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
106370011303	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
106370011304	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
106370011305	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
106370011306	nucleotide binding region [chemical binding]; other site
106370011307	ATP-binding site [chemical binding]; other site
106370011308	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
106370011309	WYL domain; Region: WYL; pfam13280
106370011310	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
106370011311	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
106370011312	catalytic center binding site [active]
106370011313	ATP binding site [chemical binding]; other site
106370011314	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
106370011315	homooctamer interface [polypeptide binding]; other site
106370011316	active site
106370011317	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
106370011318	substrate binding pocket [chemical binding]; other site
106370011319	inhibitor binding site; inhibition site
106370011320	Phosphotransferase enzyme family; Region: APH; pfam01636
106370011321	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
106370011322	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
106370011323	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
106370011324	SEC-C motif; Region: SEC-C; pfam02810
106370011325	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
106370011326	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
106370011327	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
106370011328	ATP binding site [chemical binding]; other site
106370011329	Mg2+ binding site [ion binding]; other site
106370011330	G-X-G motif; other site
106370011331	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
106370011332	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
106370011333	putative active site [active]
106370011334	catalytic triad [active]
106370011335	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
106370011336	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
106370011337	dimerization interface [polypeptide binding]; other site
106370011338	ATP binding site [chemical binding]; other site
106370011339	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
106370011340	dimerization interface [polypeptide binding]; other site
106370011341	ATP binding site [chemical binding]; other site
106370011342	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
106370011343	H+ Antiporter protein; Region: 2A0121; TIGR00900
106370011344	futalosine nucleosidase; Region: fut_nucase; TIGR03664
106370011345	Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475
106370011346	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
106370011347	active site residue [active]
106370011348	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
106370011349	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
106370011350	Catalytic domain of Protein Kinases; Region: PKc; cd00180
106370011351	active site
106370011352	ATP binding site [chemical binding]; other site
106370011353	substrate binding site [chemical binding]; other site
106370011354	activation loop (A-loop); other site
106370011355	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
106370011356	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
106370011357	DNA-binding site [nucleotide binding]; DNA binding site
106370011358	RNA-binding motif; other site
106370011359	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
106370011360	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
106370011361	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
106370011362	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
106370011363	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
106370011364	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
106370011365	phosphopeptide binding site; other site
106370011366	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
106370011367	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
106370011368	phosphopeptide binding site; other site
106370011369	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
106370011370	Protein phosphatase 2C; Region: PP2C; pfam00481
106370011371	active site
106370011372	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
106370011373	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
106370011374	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
106370011375	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
106370011376	Catalytic domain of Protein Kinases; Region: PKc; cd00180
106370011377	active site
106370011378	ATP binding site [chemical binding]; other site
106370011379	substrate binding site [chemical binding]; other site
106370011380	activation loop (A-loop); other site
106370011381	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
106370011382	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
106370011383	active site
106370011384	ATP binding site [chemical binding]; other site
106370011385	substrate binding site [chemical binding]; other site
106370011386	activation loop (A-loop); other site
106370011387	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
106370011388	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
106370011389	PASTA domain; Region: PASTA; pfam03793
106370011390	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
106370011391	Glutamine amidotransferase class-I; Region: GATase; pfam00117
106370011392	glutamine binding [chemical binding]; other site
106370011393	catalytic triad [active]
106370011394	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
106370011395	Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781
106370011396	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
106370011397	homotrimer interaction site [polypeptide binding]; other site
106370011398	putative active site [active]
106370011399	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
106370011400	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
106370011401	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
106370011402	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
106370011403	active site
106370011404	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
106370011405	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
106370011406	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
106370011407	Ligand Binding Site [chemical binding]; other site
106370011408	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
106370011409	Ligand Binding Site [chemical binding]; other site
106370011410	Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051
106370011411	catalytic site [active]
106370011412	acetyl-CoA acetyltransferase; Provisional; Region: PRK07851
106370011413	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
106370011414	dimer interface [polypeptide binding]; other site
106370011415	active site
106370011416	Domain of unknown function (DUF1918); Region: DUF1918; pfam08940
106370011417	The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Region: 2A067; TIGR00921
106370011418	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
106370011419	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
106370011420	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
106370011421	homotetramer interface [polypeptide binding]; other site
106370011422	ligand binding site [chemical binding]; other site
106370011423	catalytic site [active]
106370011424	NAD binding site [chemical binding]; other site
106370011425	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
106370011426	substrate binding site [chemical binding]; other site
106370011427	amidase catalytic site [active]
106370011428	Zn binding residues [ion binding]; other site
106370011429	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
106370011430	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
106370011431	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
106370011432	adenosine deaminase; Provisional; Region: PRK09358
106370011433	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
106370011434	active site
106370011435	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
106370011436	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
106370011437	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
106370011438	dimerization interface [polypeptide binding]; other site
106370011439	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
106370011440	Cytochrome P450; Region: p450; cl12078
106370011441	OsmC-like protein; Region: OsmC; pfam02566
106370011442	thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891
106370011443	methyltransferase, FxLD system; Region: methyltran_FxLD; TIGR04364
106370011444	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
106370011445	S-adenosylmethionine binding site [chemical binding]; other site
106370011446	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
106370011447	DNA-binding site [nucleotide binding]; DNA binding site
106370011448	RNA-binding motif; other site
106370011449	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
106370011450	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
106370011451	active site
106370011452	phosphorylation site [posttranslational modification]
106370011453	intermolecular recognition site; other site
106370011454	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
106370011455	4Fe-4S binding domain; Region: Fer4; pfam00037
106370011456	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
106370011457	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
106370011458	TPP-binding site [chemical binding]; other site
106370011459	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
106370011460	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
106370011461	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
106370011462	dimer interface [polypeptide binding]; other site
106370011463	PYR/PP interface [polypeptide binding]; other site
106370011464	TPP binding site [chemical binding]; other site
106370011465	substrate binding site [chemical binding]; other site
106370011466	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
106370011467	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
106370011468	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
106370011469	catalytic residue [active]
106370011470	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
106370011471	thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356
106370011472	ATP binding site [chemical binding]; other site
106370011473	substrate interface [chemical binding]; other site
106370011474	IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341
106370011475	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
106370011476	NifU-like domain; Region: NifU; pfam01106
106370011477	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
106370011478	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
106370011479	FeS/SAM binding site; other site
106370011480	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
106370011481	NifZ domain; Region: NifZ; pfam04319
106370011482	Nitrogen fixation protein NifW; Region: NifW; pfam03206
106370011483	Rop-like; Region: Rop-like; pfam05082
106370011484	Protein of unknown function, DUF269; Region: DUF269; pfam03270
106370011485	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
106370011486	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
106370011487	nitrogenase molybdenum-cofactor biosynthesis protein NifN; Provisional; Region: PRK14476
106370011488	nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478
106370011489	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
106370011490	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
106370011491	Domain of unknown function (DUF3364); Region: DUF3364; pfam11844
106370011492	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
106370011493	MoFe protein beta/alpha subunit interactions; other site
106370011494	Beta subunit P cluster binding residues; other site
106370011495	MoFe protein beta subunit/Fe protein contacts; other site
106370011496	MoFe protein dimer/ dimer interactions; other site
106370011497	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
106370011498	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
106370011499	MoFe protein alpha/beta subunit interactions; other site
106370011500	Alpha subunit P cluster binding residues; other site
106370011501	FeMoco binding residues [chemical binding]; other site
106370011502	MoFe protein alpha subunit/Fe protein contacts; other site
106370011503	MoFe protein dimer/ dimer interactions; other site
106370011504	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
106370011505	4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family; Region: Fer4_NifH; pfam00142
106370011506	Nucleotide-binding sites [chemical binding]; other site
106370011507	Walker A motif; other site
106370011508	Switch I region of nucleotide binding site; other site
106370011509	Fe4S4 binding sites [ion binding]; other site
106370011510	Switch II region of nucleotide binding site; other site
106370011511	homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660
106370011512	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
106370011513	active site
106370011514	catalytic residues [active]
106370011515	metal binding site [ion binding]; metal-binding site
106370011516	TOBE domain; Region: TOBE; cl01440
106370011517	TOBE domain; Region: TOBE; cl01440
106370011518	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
106370011519	active site
106370011520	Peptidase family M50; Region: Peptidase_M50; pfam02163
106370011521	putative substrate binding region [chemical binding]; other site
106370011522	FOG: CBS domain [General function prediction only]; Region: COG0517
106370011523	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
106370011524	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518
106370011525	nickel binding site [ion binding]; other site
106370011526	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
106370011527	Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941
106370011528	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
106370011529	anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221
106370011530	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
106370011531	FAD binding pocket [chemical binding]; other site
106370011532	FAD binding motif [chemical binding]; other site
106370011533	phosphate binding motif [ion binding]; other site
106370011534	beta-alpha-beta structure motif; other site
106370011535	NAD binding pocket [chemical binding]; other site
106370011536	Iron coordination center [ion binding]; other site
106370011537	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
106370011538	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
106370011539	ligand binding site [chemical binding]; other site
106370011540	flexible hinge region; other site
106370011541	4Fe-4S dicluster domain; Region: Fer4_18; pfam13746
106370011542	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
106370011543	active site
106370011544	Ap6A binding site [chemical binding]; other site
106370011545	nudix motif; other site
106370011546	metal binding site [ion binding]; metal-binding site
106370011547	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
106370011548	FOG: CBS domain [General function prediction only]; Region: COG0517
106370011549	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
106370011550	Domain of unknown function (DUF1918); Region: DUF1918; pfam08940
106370011551	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
106370011552	Part of AAA domain; Region: AAA_19; pfam13245
106370011553	Family description; Region: UvrD_C_2; pfam13538
106370011554	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
106370011555	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
106370011556	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
106370011557	P-loop; other site
106370011558	Magnesium ion binding site [ion binding]; other site
106370011559	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
106370011560	Magnesium ion binding site [ion binding]; other site
106370011561	mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583
106370011562	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
106370011563	Nuclease-related domain; Region: NERD; pfam08378
106370011564	ergothioneine biosynthesis glutamate--cysteine ligase EgtA; Region: EgtA_Cys_ligase; TIGR03444
106370011565	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
106370011566	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
106370011567	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
106370011568	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
106370011569	putative active site [active]
106370011570	putative dimer interface [polypeptide binding]; other site
106370011571	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
106370011572	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
106370011573	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
106370011574	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
106370011575	replicative DNA helicase; Region: DnaB; TIGR00665
106370011576	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
106370011577	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
106370011578	Walker A motif; other site
106370011579	ATP binding site [chemical binding]; other site
106370011580	Walker B motif; other site
106370011581	DNA binding loops [nucleotide binding]
106370011582	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
106370011583	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
106370011584	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
106370011585	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
106370011586	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
106370011587	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
106370011588	dimer interface [polypeptide binding]; other site
106370011589	ssDNA binding site [nucleotide binding]; other site
106370011590	tetramer (dimer of dimers) interface [polypeptide binding]; other site
106370011591	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
106370011592	Predicted integral membrane protein [Function unknown]; Region: COG5650
106370011593	Transglycosylase; Region: Transgly; pfam00912
106370011594	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
106370011595	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
106370011596	Predicted transcriptional regulators [Transcription]; Region: COG1695
106370011597	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
106370011598	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
106370011599	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
106370011600	H+ Antiporter protein; Region: 2A0121; TIGR00900
106370011601	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
106370011602	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
106370011603	active site
106370011604	NTP binding site [chemical binding]; other site
106370011605	metal binding triad [ion binding]; metal-binding site
106370011606	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
106370011607	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
106370011608	Zn2+ binding site [ion binding]; other site
106370011609	Mg2+ binding site [ion binding]; other site
106370011610	integral membrane protein MviN; Region: mviN; TIGR01695
106370011611	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
106370011612	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
106370011613	active site
106370011614	ATP binding site [chemical binding]; other site
106370011615	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
106370011616	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
106370011617	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
106370011618	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
106370011619	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
106370011620	catalytic residues [active]
106370011621	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
106370011622	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
106370011623	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
106370011624	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
106370011625	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
106370011626	active site
106370011627	metal binding site [ion binding]; metal-binding site
106370011628	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
106370011629	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
106370011630	ParB-like nuclease domain; Region: ParBc; pfam02195
106370011631	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
106370011632	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
106370011633	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
106370011634	Magnesium ion binding site [ion binding]; other site
106370011635	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
106370011636	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
106370011637	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
106370011638	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
106370011639	G-X-X-G motif; other site
106370011640	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
106370011641	RxxxH motif; other site
106370011642	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
106370011643	hypothetical protein; Provisional; Region: PRK14376
106370011644	Ribonuclease P; Region: Ribonuclease_P; cl00457
106370011645	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399