-- dump date 20140619_100050 -- class Genbank::misc_feature -- table misc_feature_note -- id note 298653000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 298653000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 298653000003 Walker A motif; other site 298653000004 ATP binding site [chemical binding]; other site 298653000005 Walker B motif; other site 298653000006 arginine finger; other site 298653000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 298653000008 DnaA box-binding interface [nucleotide binding]; other site 298653000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 298653000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 298653000011 putative DNA binding surface [nucleotide binding]; other site 298653000012 dimer interface [polypeptide binding]; other site 298653000013 beta-clamp/clamp loader binding surface; other site 298653000014 beta-clamp/translesion DNA polymerase binding surface; other site 298653000015 recombination protein F; Reviewed; Region: recF; PRK00064 298653000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 298653000017 Walker A/P-loop; other site 298653000018 ATP binding site [chemical binding]; other site 298653000019 Q-loop/lid; other site 298653000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 298653000021 ABC transporter signature motif; other site 298653000022 Walker B; other site 298653000023 D-loop; other site 298653000024 H-loop/switch region; other site 298653000025 Protein of unknown function (DUF721); Region: DUF721; cl02324 298653000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 298653000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653000028 Mg2+ binding site [ion binding]; other site 298653000029 G-X-G motif; other site 298653000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 298653000031 anchoring element; other site 298653000032 dimer interface [polypeptide binding]; other site 298653000033 ATP binding site [chemical binding]; other site 298653000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 298653000035 active site 298653000036 putative metal-binding site [ion binding]; other site 298653000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 298653000038 DNA gyrase subunit A; Validated; Region: PRK05560 298653000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 298653000040 CAP-like domain; other site 298653000041 active site 298653000042 primary dimer interface [polypeptide binding]; other site 298653000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 298653000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 298653000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 298653000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 298653000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 298653000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 298653000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 298653000050 Methyltransferase domain; Region: Methyltransf_24; pfam13578 298653000051 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 298653000052 Protein of unknown function, DUF608; Region: DUF608; pfam04685 298653000053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653000054 S-adenosylmethionine binding site [chemical binding]; other site 298653000055 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 298653000056 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 298653000057 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 298653000058 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653000059 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 298653000060 oligomer interface [polypeptide binding]; other site 298653000061 active site residues [active] 298653000062 Secretory lipase; Region: LIP; pfam03583 298653000063 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 298653000064 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 298653000065 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 298653000066 Nitrogen regulatory protein P-II; Region: P-II; smart00938 298653000067 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 298653000068 substrate binding site [chemical binding]; other site 298653000069 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 298653000070 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653000071 dimer interface [polypeptide binding]; other site 298653000072 conserved gate region; other site 298653000073 putative PBP binding loops; other site 298653000074 ABC-ATPase subunit interface; other site 298653000075 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 298653000076 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 298653000077 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 298653000078 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 298653000079 Walker A/P-loop; other site 298653000080 ATP binding site [chemical binding]; other site 298653000081 Q-loop/lid; other site 298653000082 ABC transporter signature motif; other site 298653000083 Walker B; other site 298653000084 D-loop; other site 298653000085 H-loop/switch region; other site 298653000086 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 298653000087 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 298653000088 AAA domain; Region: AAA_31; pfam13614 298653000089 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 298653000090 P-loop; other site 298653000091 Magnesium ion binding site [ion binding]; other site 298653000092 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 298653000093 Magnesium ion binding site [ion binding]; other site 298653000094 Replication-relaxation; Region: Replic_Relax; pfam13814 298653000095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653000096 methyltransferase, FxLD system; Region: methyltran_FxLD; TIGR04364 298653000097 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 298653000098 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 298653000099 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653000100 non-specific DNA binding site [nucleotide binding]; other site 298653000101 salt bridge; other site 298653000102 sequence-specific DNA binding site [nucleotide binding]; other site 298653000103 Domain of unknown function (DUF397); Region: DUF397; pfam04149 298653000104 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 298653000105 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 298653000106 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 298653000107 active site 298653000108 catalytic residues [active] 298653000109 DNA binding site [nucleotide binding] 298653000110 Int/Topo IB signature motif; other site 298653000111 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 298653000112 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 298653000113 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 298653000114 Phosphotransferase enzyme family; Region: APH; pfam01636 298653000115 active site 298653000116 substrate binding site [chemical binding]; other site 298653000117 ATP binding site [chemical binding]; other site 298653000118 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 298653000119 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 298653000120 catalytic residues [active] 298653000121 catalytic nucleophile [active] 298653000122 Presynaptic Site I dimer interface [polypeptide binding]; other site 298653000123 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 298653000124 Synaptic Flat tetramer interface [polypeptide binding]; other site 298653000125 Synaptic Site I dimer interface [polypeptide binding]; other site 298653000126 DNA binding site [nucleotide binding] 298653000127 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 298653000128 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 298653000129 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 298653000130 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653000131 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653000132 NAD(P) binding site [chemical binding]; other site 298653000133 active site 298653000134 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 298653000135 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 298653000136 active site 298653000137 zinc binding site [ion binding]; other site 298653000138 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 298653000139 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 298653000140 SpaB C-terminal domain; Region: SpaB_C; pfam14028 298653000141 methyltransferase, FxLD system; Region: methyltran_FxLD; TIGR04364 298653000142 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653000143 S-adenosylmethionine binding site [chemical binding]; other site 298653000144 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 298653000145 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653000146 active site 298653000147 ATP binding site [chemical binding]; other site 298653000148 substrate binding site [chemical binding]; other site 298653000149 activation loop (A-loop); other site 298653000150 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653000151 sequence-specific DNA binding site [nucleotide binding]; other site 298653000152 salt bridge; other site 298653000153 Domain of unknown function (DUF955); Region: DUF955; cl01076 298653000154 Homeodomain-like domain; Region: HTH_23; pfam13384 298653000155 Winged helix-turn helix; Region: HTH_29; pfam13551 298653000156 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 298653000157 active site 298653000158 catalytic residues [active] 298653000159 DDE superfamily endonuclease; Region: DDE_3; pfam13358 298653000160 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 298653000161 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 298653000162 Homeodomain-like domain; Region: HTH_32; pfam13565 298653000163 Winged helix-turn helix; Region: HTH_33; pfam13592 298653000164 AAA ATPase domain; Region: AAA_16; pfam13191 298653000165 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653000166 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653000167 DNA binding residues [nucleotide binding] 298653000168 dimerization interface [polypeptide binding]; other site 298653000169 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 298653000170 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 298653000171 homodimer interface [polypeptide binding]; other site 298653000172 active site 298653000173 TDP-binding site; other site 298653000174 acceptor substrate-binding pocket; other site 298653000175 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 298653000176 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 298653000177 [2Fe-2S] cluster binding site [ion binding]; other site 298653000178 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 298653000179 putative alpha subunit interface [polypeptide binding]; other site 298653000180 putative active site [active] 298653000181 putative substrate binding site [chemical binding]; other site 298653000182 Fe binding site [ion binding]; other site 298653000183 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 298653000184 short chain dehydrogenase; Provisional; Region: PRK06197 298653000185 putative NAD(P) binding site [chemical binding]; other site 298653000186 active site 298653000187 short chain dehydrogenase; Provisional; Region: PRK05693 298653000188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653000189 NAD(P) binding site [chemical binding]; other site 298653000190 active site 298653000191 Predicted transcriptional regulators [Transcription]; Region: COG1695 298653000192 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 298653000193 HAMP domain; Region: HAMP; pfam00672 298653000194 dimerization interface [polypeptide binding]; other site 298653000195 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 298653000196 dimer interface [polypeptide binding]; other site 298653000197 phosphorylation site [posttranslational modification] 298653000198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653000199 ATP binding site [chemical binding]; other site 298653000200 Mg2+ binding site [ion binding]; other site 298653000201 G-X-G motif; other site 298653000202 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 298653000203 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653000204 active site 298653000205 phosphorylation site [posttranslational modification] 298653000206 intermolecular recognition site; other site 298653000207 dimerization interface [polypeptide binding]; other site 298653000208 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 298653000209 DNA binding site [nucleotide binding] 298653000210 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 298653000211 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 298653000212 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 298653000213 Walker A/P-loop; other site 298653000214 ATP binding site [chemical binding]; other site 298653000215 Q-loop/lid; other site 298653000216 ABC transporter signature motif; other site 298653000217 Walker B; other site 298653000218 D-loop; other site 298653000219 H-loop/switch region; other site 298653000220 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 298653000221 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 298653000222 FtsX-like permease family; Region: FtsX; pfam02687 298653000223 Predicted membrane protein [Function unknown]; Region: COG3462 298653000224 Short C-terminal domain; Region: SHOCT; pfam09851 298653000225 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 298653000226 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 298653000227 DNA binding residues [nucleotide binding] 298653000228 putative dimer interface [polypeptide binding]; other site 298653000229 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 298653000230 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 298653000231 active site 298653000232 catalytic tetrad [active] 298653000233 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 298653000234 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 298653000235 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 298653000236 DNA binding residues [nucleotide binding] 298653000237 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 298653000238 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 298653000239 putative NAD(P) binding site [chemical binding]; other site 298653000240 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 298653000241 DNA-binding site [nucleotide binding]; DNA binding site 298653000242 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653000243 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 298653000244 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 298653000245 Amidohydrolase; Region: Amidohydro_2; pfam04909 298653000246 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 298653000247 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 298653000248 NAD(P) binding site [chemical binding]; other site 298653000249 enoyl-CoA hydratase; Provisional; Region: PRK08252 298653000250 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653000251 substrate binding site [chemical binding]; other site 298653000252 oxyanion hole (OAH) forming residues; other site 298653000253 trimer interface [polypeptide binding]; other site 298653000254 Phosphotransferase enzyme family; Region: APH; pfam01636 298653000255 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 298653000256 putative active site [active] 298653000257 putative substrate binding site [chemical binding]; other site 298653000258 ATP binding site [chemical binding]; other site 298653000259 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653000260 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653000261 active site 298653000262 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 298653000263 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653000264 metal binding site [ion binding]; metal-binding site 298653000265 active site 298653000266 I-site; other site 298653000267 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653000268 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653000269 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 298653000270 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 298653000271 putative hydrophobic ligand binding site [chemical binding]; other site 298653000272 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 298653000273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 298653000274 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 298653000275 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 298653000276 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 298653000277 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 298653000278 Walker A/P-loop; other site 298653000279 ATP binding site [chemical binding]; other site 298653000280 Q-loop/lid; other site 298653000281 ABC transporter signature motif; other site 298653000282 Walker B; other site 298653000283 D-loop; other site 298653000284 H-loop/switch region; other site 298653000285 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 298653000286 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 298653000287 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 298653000288 substrate binding site [chemical binding]; other site 298653000289 amidase catalytic site [active] 298653000290 Zn binding residues [ion binding]; other site 298653000291 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 298653000292 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 298653000293 Adenosylhomocysteinase; Provisional; Region: PTZ00075 298653000294 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 298653000295 homotetramer interface [polypeptide binding]; other site 298653000296 ligand binding site [chemical binding]; other site 298653000297 catalytic site [active] 298653000298 NAD binding site [chemical binding]; other site 298653000299 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 298653000300 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 298653000301 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 298653000302 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 298653000303 active site 298653000304 Phosphotransferase enzyme family; Region: APH; pfam01636 298653000305 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 298653000306 putative active site [active] 298653000307 putative substrate binding site [chemical binding]; other site 298653000308 ATP binding site [chemical binding]; other site 298653000309 Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 298653000310 catalytic site [active] 298653000311 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 298653000312 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 298653000313 Ligand Binding Site [chemical binding]; other site 298653000314 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 298653000315 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 298653000316 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 298653000317 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 298653000318 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 298653000319 active site 298653000320 Rhomboid family; Region: Rhomboid; pfam01694 298653000321 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 298653000322 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 298653000323 Probable transposase; Region: OrfB_IS605; pfam01385 298653000324 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 298653000325 Predicted ATPase [General function prediction only]; Region: COG3903 298653000326 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 298653000327 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 298653000328 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 298653000329 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 298653000330 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 298653000331 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 298653000332 Glutamine amidotransferase class-I; Region: GATase; pfam00117 298653000333 glutamine binding [chemical binding]; other site 298653000334 catalytic triad [active] 298653000335 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653000336 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 298653000337 active site 298653000338 ATP binding site [chemical binding]; other site 298653000339 substrate binding site [chemical binding]; other site 298653000340 activation loop (A-loop); other site 298653000341 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 298653000342 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 298653000343 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653000344 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653000345 active site 298653000346 ATP binding site [chemical binding]; other site 298653000347 substrate binding site [chemical binding]; other site 298653000348 activation loop (A-loop); other site 298653000349 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 298653000350 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 298653000351 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 298653000352 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 298653000353 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 298653000354 Protein phosphatase 2C; Region: PP2C; pfam00481 298653000355 active site 298653000356 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 298653000357 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 298653000358 phosphopeptide binding site; other site 298653000359 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 298653000360 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 298653000361 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 298653000362 phosphopeptide binding site; other site 298653000363 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 298653000364 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653000365 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653000366 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653000367 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653000368 active site 298653000369 ATP binding site [chemical binding]; other site 298653000370 substrate binding site [chemical binding]; other site 298653000371 activation loop (A-loop); other site 298653000372 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 298653000373 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 298653000374 DNA-binding site [nucleotide binding]; DNA binding site 298653000375 RNA-binding motif; other site 298653000376 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 298653000377 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 298653000378 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 298653000379 Ligand Binding Site [chemical binding]; other site 298653000380 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 298653000381 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 298653000382 active site residue [active] 298653000383 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 298653000384 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 298653000385 hypothetical protein; Provisional; Region: PRK08236 298653000386 Major Facilitator Superfamily; Region: MFS_1; pfam07690 298653000387 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 298653000388 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 298653000389 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 298653000390 dimerization interface [polypeptide binding]; other site 298653000391 ATP binding site [chemical binding]; other site 298653000392 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 298653000393 dimerization interface [polypeptide binding]; other site 298653000394 ATP binding site [chemical binding]; other site 298653000395 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 298653000396 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 298653000397 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 298653000398 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 298653000399 conserved cys residue [active] 298653000400 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 298653000401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 298653000402 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 298653000403 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 298653000404 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 298653000405 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 298653000406 SEC-C motif; Region: SEC-C; pfam02810 298653000407 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 298653000408 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 298653000409 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 298653000410 AIR carboxylase; Region: AIRC; cl00310 298653000411 Phosphotransferase enzyme family; Region: APH; pfam01636 298653000412 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 298653000413 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 298653000414 Coenzyme A binding pocket [chemical binding]; other site 298653000415 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 298653000416 substrate binding pocket [chemical binding]; other site 298653000417 inhibitor binding site; inhibition site 298653000418 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 298653000419 homooctamer interface [polypeptide binding]; other site 298653000420 active site 298653000421 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 298653000422 catalytic center binding site [active] 298653000423 ATP binding site [chemical binding]; other site 298653000424 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 298653000425 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 298653000426 WYL domain; Region: WYL; pfam13280 298653000427 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 298653000428 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 298653000429 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 298653000430 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 298653000431 ATP binding site [chemical binding]; other site 298653000432 putative Mg++ binding site [ion binding]; other site 298653000433 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 298653000434 nucleotide binding region [chemical binding]; other site 298653000435 ATP-binding site [chemical binding]; other site 298653000436 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 298653000437 putative active site [active] 298653000438 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 298653000439 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 298653000440 ring oligomerisation interface [polypeptide binding]; other site 298653000441 ATP/Mg binding site [chemical binding]; other site 298653000442 stacking interactions; other site 298653000443 hinge regions; other site 298653000444 threonine synthase; Validated; Region: PRK07591 298653000445 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 298653000446 homodimer interface [polypeptide binding]; other site 298653000447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 298653000448 catalytic residue [active] 298653000449 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 298653000450 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 298653000451 active site 298653000452 motif I; other site 298653000453 motif II; other site 298653000454 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 298653000455 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 298653000456 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 298653000457 active site 298653000458 homotetramer interface [polypeptide binding]; other site 298653000459 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 298653000460 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 298653000461 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 298653000462 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 298653000463 RNHCP domain; Region: RNHCP; pfam12647 298653000464 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 298653000465 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 298653000466 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 298653000467 NAD(P) binding site [chemical binding]; other site 298653000468 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 298653000469 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 298653000470 TrkA-N domain; Region: TrkA_N; pfam02254 298653000471 active site 298653000472 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 298653000473 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 298653000474 active site 298653000475 metal binding site [ion binding]; metal-binding site 298653000476 Clp protease ATP binding subunit; Region: clpC; CHL00095 298653000477 Clp amino terminal domain; Region: Clp_N; pfam02861 298653000478 Clp amino terminal domain; Region: Clp_N; pfam02861 298653000479 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 298653000480 Walker A motif; other site 298653000481 ATP binding site [chemical binding]; other site 298653000482 Walker B motif; other site 298653000483 arginine finger; other site 298653000484 UvrB/uvrC motif; Region: UVR; pfam02151 298653000485 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 298653000486 Walker A motif; other site 298653000487 ATP binding site [chemical binding]; other site 298653000488 Walker B motif; other site 298653000489 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 298653000490 AAA domain; Region: AAA_31; pfam13614 298653000491 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 298653000492 P-loop; other site 298653000493 Magnesium ion binding site [ion binding]; other site 298653000494 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 298653000495 Magnesium ion binding site [ion binding]; other site 298653000496 Flavoprotein; Region: Flavoprotein; cl08021 298653000497 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 298653000498 active site 298653000499 catalytic triad [active] 298653000500 oxyanion hole [active] 298653000501 pantothenate kinase; Reviewed; Region: PRK13318 298653000502 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 298653000503 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 298653000504 dimerization interface [polypeptide binding]; other site 298653000505 active site 298653000506 L-aspartate oxidase; Provisional; Region: PRK07804 298653000507 L-aspartate oxidase; Provisional; Region: PRK06175 298653000508 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 298653000509 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 298653000510 tetramerization interface [polypeptide binding]; other site 298653000511 active site 298653000512 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 298653000513 pantoate--beta-alanine ligase; Region: panC; TIGR00018 298653000514 active site 298653000515 nucleotide binding site [chemical binding]; other site 298653000516 HIGH motif; other site 298653000517 KMSKS motif; other site 298653000518 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 298653000519 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 298653000520 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 298653000521 ATP binding site [chemical binding]; other site 298653000522 active site 298653000523 substrate binding site [chemical binding]; other site 298653000524 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 298653000525 adenylosuccinate lyase; Provisional; Region: PRK07492 298653000526 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 298653000527 tetramer interface [polypeptide binding]; other site 298653000528 active site 298653000529 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 298653000530 AIR carboxylase; Region: AIRC; pfam00731 298653000531 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 298653000532 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 298653000533 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 298653000534 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 298653000535 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 298653000536 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 298653000537 GDP-binding site [chemical binding]; other site 298653000538 ACT binding site; other site 298653000539 IMP binding site; other site 298653000540 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 298653000541 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 298653000542 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 298653000543 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 298653000544 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK12911 298653000545 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 298653000546 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 298653000547 active site 298653000548 intersubunit interface [polypeptide binding]; other site 298653000549 zinc binding site [ion binding]; other site 298653000550 Na+ binding site [ion binding]; other site 298653000551 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 298653000552 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 298653000553 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 298653000554 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 298653000555 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 298653000556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653000557 NAD(P) binding site [chemical binding]; other site 298653000558 active site 298653000559 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653000560 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 298653000561 active site 298653000562 NTP binding site [chemical binding]; other site 298653000563 metal binding triad [ion binding]; metal-binding site 298653000564 Bacterial PH domain; Region: DUF304; pfam03703 298653000565 Bacterial PH domain; Region: DUF304; pfam03703 298653000566 Bacterial PH domain; Region: DUF304; pfam03703 298653000567 Uncharacterized conserved protein [Function unknown]; Region: COG3402 298653000568 MMPL family; Region: MMPL; pfam03176 298653000569 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 298653000570 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 298653000571 Clp amino terminal domain; Region: Clp_N; pfam02861 298653000572 Clp amino terminal domain; Region: Clp_N; pfam02861 298653000573 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 298653000574 Walker A motif; other site 298653000575 ATP binding site [chemical binding]; other site 298653000576 Walker B motif; other site 298653000577 arginine finger; other site 298653000578 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 298653000579 Walker A motif; other site 298653000580 ATP binding site [chemical binding]; other site 298653000581 Walker B motif; other site 298653000582 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 298653000583 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 298653000584 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 298653000585 DNA binding residues [nucleotide binding] 298653000586 putative dimer interface [polypeptide binding]; other site 298653000587 chaperone protein DnaJ; Provisional; Region: PRK14295 298653000588 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 298653000589 HSP70 interaction site [polypeptide binding]; other site 298653000590 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 298653000591 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 298653000592 dimer interface [polypeptide binding]; other site 298653000593 GrpE; Region: GrpE; pfam01025 298653000594 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 298653000595 dimer interface [polypeptide binding]; other site 298653000596 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 298653000597 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 298653000598 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 298653000599 nucleotide binding site [chemical binding]; other site 298653000600 NEF interaction site [polypeptide binding]; other site 298653000601 SBD interface [polypeptide binding]; other site 298653000602 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 298653000603 4Fe-4S binding domain; Region: Fer4; cl02805 298653000604 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 298653000605 4Fe-4S binding domain; Region: Fer4; pfam00037 298653000606 Cysteine-rich domain; Region: CCG; pfam02754 298653000607 Cysteine-rich domain; Region: CCG; pfam02754 298653000608 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 298653000609 trimer interface [polypeptide binding]; other site 298653000610 active site 298653000611 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 298653000612 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 298653000613 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 298653000614 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 298653000615 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 298653000616 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653000617 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653000618 active site 298653000619 ATP binding site [chemical binding]; other site 298653000620 substrate binding site [chemical binding]; other site 298653000621 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 298653000622 substrate binding site [chemical binding]; other site 298653000623 activation loop (A-loop); other site 298653000624 activation loop (A-loop); other site 298653000625 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 298653000626 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653000627 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653000628 active site 298653000629 ATP binding site [chemical binding]; other site 298653000630 substrate binding site [chemical binding]; other site 298653000631 activation loop (A-loop); other site 298653000632 short chain dehydrogenase; Provisional; Region: PRK08303 298653000633 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653000634 NAD(P) binding site [chemical binding]; other site 298653000635 active site 298653000636 Predicted transcriptional regulators [Transcription]; Region: COG1733 298653000637 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 298653000638 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 298653000639 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 298653000640 apolar tunnel; other site 298653000641 heme binding site [chemical binding]; other site 298653000642 dimerization interface [polypeptide binding]; other site 298653000643 Predicted transcriptional regulator [Transcription]; Region: COG2378 298653000644 HTH domain; Region: HTH_11; pfam08279 298653000645 WYL domain; Region: WYL; pfam13280 298653000646 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 298653000647 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 298653000648 putative active site [active] 298653000649 putative dimer interface [polypeptide binding]; other site 298653000650 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 298653000651 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 298653000652 GAF domain; Region: GAF; pfam01590 298653000653 GAF domain; Region: GAF_2; pfam13185 298653000654 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 298653000655 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 298653000656 Walker A/P-loop; other site 298653000657 ATP binding site [chemical binding]; other site 298653000658 Q-loop/lid; other site 298653000659 ABC transporter signature motif; other site 298653000660 Walker B; other site 298653000661 D-loop; other site 298653000662 H-loop/switch region; other site 298653000663 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 298653000664 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 298653000665 Helix-turn-helix domain; Region: HTH_17; pfam12728 298653000666 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 298653000667 active site 298653000668 metal binding site [ion binding]; metal-binding site 298653000669 interdomain interaction site; other site 298653000670 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 298653000671 Helix-turn-helix domain; Region: HTH_17; pfam12728 298653000672 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 298653000673 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 298653000674 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 298653000675 DNA binding residues [nucleotide binding] 298653000676 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 298653000677 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 298653000678 NAD(P) binding site [chemical binding]; other site 298653000679 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 298653000680 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 298653000681 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 298653000682 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 298653000683 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653000684 sequence-specific DNA binding site [nucleotide binding]; other site 298653000685 salt bridge; other site 298653000686 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 298653000687 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 298653000688 active site 298653000689 motif I; other site 298653000690 motif II; other site 298653000691 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 298653000692 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 298653000693 homodimer interface [polypeptide binding]; other site 298653000694 putative metal binding site [ion binding]; other site 298653000695 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 298653000696 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 298653000697 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 298653000698 glutaminase A; Region: Gln_ase; TIGR03814 298653000699 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 298653000700 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 298653000701 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 298653000702 ligand binding site [chemical binding]; other site 298653000703 flexible hinge region; other site 298653000704 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 298653000705 homodecamer interface [polypeptide binding]; other site 298653000706 GTP cyclohydrolase I; Provisional; Region: PLN03044 298653000707 active site 298653000708 putative catalytic site residues [active] 298653000709 zinc binding site [ion binding]; other site 298653000710 GTP-CH-I/GFRP interaction surface; other site 298653000711 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 298653000712 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 298653000713 Walker A motif; other site 298653000714 ATP binding site [chemical binding]; other site 298653000715 Walker B motif; other site 298653000716 arginine finger; other site 298653000717 Peptidase family M41; Region: Peptidase_M41; pfam01434 298653000718 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 298653000719 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 298653000720 Ligand Binding Site [chemical binding]; other site 298653000721 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 298653000722 active site 298653000723 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 298653000724 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 298653000725 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 298653000726 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 298653000727 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 298653000728 dimer interface [polypeptide binding]; other site 298653000729 substrate binding site [chemical binding]; other site 298653000730 metal binding sites [ion binding]; metal-binding site 298653000731 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 298653000732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653000733 active site 298653000734 phosphorylation site [posttranslational modification] 298653000735 intermolecular recognition site; other site 298653000736 dimerization interface [polypeptide binding]; other site 298653000737 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 298653000738 DNA binding site [nucleotide binding] 298653000739 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 298653000740 catalytic core [active] 298653000741 PSP1 C-terminal conserved region; Region: PSP1; cl00770 298653000742 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 298653000743 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 298653000744 active site 298653000745 metal binding site [ion binding]; metal-binding site 298653000746 DNA polymerase III subunit delta'; Validated; Region: PRK07940 298653000747 DNA polymerase III subunit delta'; Validated; Region: PRK08485 298653000748 H+ Antiporter protein; Region: 2A0121; TIGR00900 298653000749 thymidylate kinase; Validated; Region: tmk; PRK00698 298653000750 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 298653000751 TMP-binding site; other site 298653000752 ATP-binding site [chemical binding]; other site 298653000753 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 298653000754 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 298653000755 active site 298653000756 interdomain interaction site; other site 298653000757 putative metal-binding site [ion binding]; other site 298653000758 nucleotide binding site [chemical binding]; other site 298653000759 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 298653000760 domain I; other site 298653000761 phosphate binding site [ion binding]; other site 298653000762 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 298653000763 domain II; other site 298653000764 domain III; other site 298653000765 nucleotide binding site [chemical binding]; other site 298653000766 DNA binding groove [nucleotide binding] 298653000767 catalytic site [active] 298653000768 domain IV; other site 298653000769 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 298653000770 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 298653000771 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 298653000772 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 298653000773 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 298653000774 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 298653000775 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 298653000776 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 298653000777 anti sigma factor interaction site; other site 298653000778 regulatory phosphorylation site [posttranslational modification]; other site 298653000779 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 298653000780 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 298653000781 ATP binding site [chemical binding]; other site 298653000782 putative Mg++ binding site [ion binding]; other site 298653000783 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 298653000784 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 298653000785 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 298653000786 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 298653000787 Walker A motif; other site 298653000788 ATP binding site [chemical binding]; other site 298653000789 Walker B motif; other site 298653000790 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 298653000791 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 298653000792 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 298653000793 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 298653000794 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 298653000795 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 298653000796 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 298653000797 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 298653000798 putative active site [active] 298653000799 putative CoA binding site [chemical binding]; other site 298653000800 nudix motif; other site 298653000801 metal binding site [ion binding]; metal-binding site 298653000802 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 298653000803 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 298653000804 minor groove reading motif; other site 298653000805 helix-hairpin-helix signature motif; other site 298653000806 substrate binding pocket [chemical binding]; other site 298653000807 active site 298653000808 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 298653000809 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 298653000810 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 298653000811 ligand binding site [chemical binding]; other site 298653000812 flexible hinge region; other site 298653000813 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 298653000814 putative switch regulator; other site 298653000815 non-specific DNA interactions [nucleotide binding]; other site 298653000816 DNA binding site [nucleotide binding] 298653000817 sequence specific DNA binding site [nucleotide binding]; other site 298653000818 putative cAMP binding site [chemical binding]; other site 298653000819 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 298653000820 Double zinc ribbon; Region: DZR; pfam12773 298653000821 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 298653000822 cyclase homology domain; Region: CHD; cd07302 298653000823 nucleotidyl binding site; other site 298653000824 metal binding site [ion binding]; metal-binding site 298653000825 dimer interface [polypeptide binding]; other site 298653000826 AAA ATPase domain; Region: AAA_16; pfam13191 298653000827 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653000828 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653000829 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 298653000830 TPR motif; other site 298653000831 binding surface 298653000832 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 298653000833 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 298653000834 homotrimer interaction site [polypeptide binding]; other site 298653000835 putative active site [active] 298653000836 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 298653000837 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 298653000838 DTAP/Switch II; other site 298653000839 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 298653000840 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 298653000841 DTAP/Switch II; other site 298653000842 Switch I; other site 298653000843 Transcription factor WhiB; Region: Whib; pfam02467 298653000844 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 298653000845 Transglycosylase; Region: Transgly; pfam00912 298653000846 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 298653000847 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 298653000848 Yqey-like protein; Region: YqeY; cl17540 298653000849 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 298653000850 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 298653000851 putative active site [active] 298653000852 putative metal binding site [ion binding]; other site 298653000853 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653000854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653000855 active site 298653000856 phosphorylation site [posttranslational modification] 298653000857 intermolecular recognition site; other site 298653000858 dimerization interface [polypeptide binding]; other site 298653000859 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653000860 DNA binding residues [nucleotide binding] 298653000861 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 298653000862 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 298653000863 NAD(P) binding site [chemical binding]; other site 298653000864 short chain dehydrogenase; Provisional; Region: PRK06940 298653000865 classical (c) SDRs; Region: SDR_c; cd05233 298653000866 NAD(P) binding site [chemical binding]; other site 298653000867 active site 298653000868 enoyl-CoA hydratase; Provisional; Region: PRK06190 298653000869 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653000870 substrate binding site [chemical binding]; other site 298653000871 oxyanion hole (OAH) forming residues; other site 298653000872 trimer interface [polypeptide binding]; other site 298653000873 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 298653000874 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 298653000875 NAD binding site [chemical binding]; other site 298653000876 catalytic residues [active] 298653000877 prolyl-tRNA synthetase; Provisional; Region: PRK08661 298653000878 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 298653000879 dimer interface [polypeptide binding]; other site 298653000880 motif 1; other site 298653000881 active site 298653000882 motif 2; other site 298653000883 motif 3; other site 298653000884 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 298653000885 anticodon binding site; other site 298653000886 Frankia-40 domain; Region: Frankia_40_dom; TIGR03917 298653000887 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 298653000888 PBP superfamily domain; Region: PBP_like_2; cl17296 298653000889 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 298653000890 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653000891 dimer interface [polypeptide binding]; other site 298653000892 conserved gate region; other site 298653000893 putative PBP binding loops; other site 298653000894 ABC-ATPase subunit interface; other site 298653000895 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 298653000896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653000897 dimer interface [polypeptide binding]; other site 298653000898 conserved gate region; other site 298653000899 putative PBP binding loops; other site 298653000900 ABC-ATPase subunit interface; other site 298653000901 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 298653000902 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 298653000903 Walker A/P-loop; other site 298653000904 ATP binding site [chemical binding]; other site 298653000905 Q-loop/lid; other site 298653000906 ABC transporter signature motif; other site 298653000907 Walker B; other site 298653000908 D-loop; other site 298653000909 H-loop/switch region; other site 298653000910 Response regulator receiver domain; Region: Response_reg; pfam00072 298653000911 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653000912 active site 298653000913 phosphorylation site [posttranslational modification] 298653000914 intermolecular recognition site; other site 298653000915 dimerization interface [polypeptide binding]; other site 298653000916 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 298653000917 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 298653000918 DNA binding site [nucleotide binding] 298653000919 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 298653000920 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 298653000921 minor groove reading motif; other site 298653000922 helix-hairpin-helix signature motif; other site 298653000923 active site 298653000924 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 298653000925 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 298653000926 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 298653000927 DNA repair protein RadA; Provisional; Region: PRK11823 298653000928 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 298653000929 Walker A motif; other site 298653000930 ATP binding site [chemical binding]; other site 298653000931 Walker B motif; other site 298653000932 Protein of unknown function (DUF461); Region: DUF461; cl01071 298653000933 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 298653000934 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 298653000935 substrate binding site; other site 298653000936 dimer interface; other site 298653000937 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 298653000938 homotrimer interaction site [polypeptide binding]; other site 298653000939 zinc binding site [ion binding]; other site 298653000940 CDP-binding sites; other site 298653000941 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 298653000942 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 298653000943 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 298653000944 active site 298653000945 HIGH motif; other site 298653000946 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 298653000947 KMSKS motif; other site 298653000948 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 298653000949 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 298653000950 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 298653000951 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 298653000952 phosphopeptide binding site; other site 298653000953 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 298653000954 metal ion-dependent adhesion site (MIDAS); other site 298653000955 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 298653000956 Double zinc ribbon; Region: DZR; pfam12773 298653000957 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 298653000958 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 298653000959 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 298653000960 active site 298653000961 ATP binding site [chemical binding]; other site 298653000962 substrate binding site [chemical binding]; other site 298653000963 activation loop (A-loop); other site 298653000964 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 298653000965 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 298653000966 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 298653000967 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 298653000968 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 298653000969 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 298653000970 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 298653000971 DNA binding residues [nucleotide binding] 298653000972 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 298653000973 ABC-2 type transporter; Region: ABC2_membrane; cl17235 298653000974 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 298653000975 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 298653000976 Walker A/P-loop; other site 298653000977 ATP binding site [chemical binding]; other site 298653000978 Q-loop/lid; other site 298653000979 ABC transporter signature motif; other site 298653000980 Walker B; other site 298653000981 D-loop; other site 298653000982 H-loop/switch region; other site 298653000983 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 298653000984 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 298653000985 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 298653000986 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 298653000987 Walker A/P-loop; other site 298653000988 ATP binding site [chemical binding]; other site 298653000989 Q-loop/lid; other site 298653000990 ABC transporter signature motif; other site 298653000991 Walker B; other site 298653000992 D-loop; other site 298653000993 H-loop/switch region; other site 298653000994 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 298653000995 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 298653000996 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 298653000997 Walker A/P-loop; other site 298653000998 ATP binding site [chemical binding]; other site 298653000999 Q-loop/lid; other site 298653001000 ABC transporter signature motif; other site 298653001001 Walker B; other site 298653001002 D-loop; other site 298653001003 H-loop/switch region; other site 298653001004 GAF domain; Region: GAF; pfam01590 298653001005 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 298653001006 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 298653001007 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 298653001008 NodB motif; other site 298653001009 putative active site [active] 298653001010 putative catalytic site [active] 298653001011 putative Zn binding site [ion binding]; other site 298653001012 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 298653001013 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 298653001014 active site 298653001015 homodimer interface [polypeptide binding]; other site 298653001016 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 298653001017 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 298653001018 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 298653001019 active site 298653001020 Putative sensor; Region: Sensor; pfam13796 298653001021 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 298653001022 Histidine kinase; Region: HisKA_3; pfam07730 298653001023 Nitrate and nitrite sensing; Region: NIT; pfam08376 298653001024 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 298653001025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653001026 ATP binding site [chemical binding]; other site 298653001027 Mg2+ binding site [ion binding]; other site 298653001028 G-X-G motif; other site 298653001029 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 298653001030 Protein of unknown function (DUF742); Region: DUF742; pfam05331 298653001031 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 298653001032 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 298653001033 G2 box; other site 298653001034 Switch I region; other site 298653001035 G3 box; other site 298653001036 Switch II region; other site 298653001037 G4 box; other site 298653001038 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 298653001039 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 298653001040 cyclase homology domain; Region: CHD; cd07302 298653001041 nucleotidyl binding site; other site 298653001042 metal binding site [ion binding]; metal-binding site 298653001043 dimer interface [polypeptide binding]; other site 298653001044 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 298653001045 Predicted kinase [General function prediction only]; Region: COG0645 298653001046 AAA domain; Region: AAA_17; pfam13207 298653001047 NACHT domain; Region: NACHT; pfam05729 298653001048 Uncharacterized conserved protein [Function unknown]; Region: COG4933 298653001049 Helix-turn-helix domain; Region: HTH_19; pfam12844 298653001050 Integrase core domain; Region: rve; pfam00665 298653001051 Integrase core domain; Region: rve_3; pfam13683 298653001052 lumazine synthase and riboflavin synthase; involved in the riboflavin (vitamin B2) biosynthetic pathway; Region: Lumazine_synthase-like; cl00317 298653001053 active site 298653001054 homopentamer interface [polypeptide binding]; other site 298653001055 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 298653001056 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 298653001057 TPP-binding site [chemical binding]; other site 298653001058 dimer interface [polypeptide binding]; other site 298653001059 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 298653001060 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 298653001061 PYR/PP interface [polypeptide binding]; other site 298653001062 dimer interface [polypeptide binding]; other site 298653001063 TPP binding site [chemical binding]; other site 298653001064 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 298653001065 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 298653001066 bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791 298653001067 N- and C-terminal domain interface [polypeptide binding]; other site 298653001068 active site 298653001069 MgATP binding site [chemical binding]; other site 298653001070 catalytic site [active] 298653001071 metal binding site [ion binding]; metal-binding site 298653001072 putative homotetramer interface [polypeptide binding]; other site 298653001073 putative homodimer interface [polypeptide binding]; other site 298653001074 glycerol binding site [chemical binding]; other site 298653001075 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 298653001076 MarR family; Region: MarR_2; pfam12802 298653001077 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 298653001078 HTH-like domain; Region: HTH_21; pfam13276 298653001079 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 298653001080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653001081 hypothetical protein; Provisional; Region: PRK06194 298653001082 classical (c) SDRs; Region: SDR_c; cd05233 298653001083 NAD(P) binding site [chemical binding]; other site 298653001084 active site 298653001085 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 298653001086 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 298653001087 putative active site [active] 298653001088 putative NTP binding site [chemical binding]; other site 298653001089 putative nucleic acid binding site [nucleotide binding]; other site 298653001090 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 298653001091 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 298653001092 Int/Topo IB signature motif; other site 298653001093 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 298653001094 active site 298653001095 DNA binding site [nucleotide binding] 298653001096 Int/Topo IB signature motif; other site 298653001097 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 298653001098 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 298653001099 active site 298653001100 DNA binding site [nucleotide binding] 298653001101 Int/Topo IB signature motif; other site 298653001102 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 298653001103 Transcriptional regulators [Transcription]; Region: PurR; COG1609 298653001104 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 298653001105 DNA binding site [nucleotide binding] 298653001106 domain linker motif; other site 298653001107 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 298653001108 dimerization interface [polypeptide binding]; other site 298653001109 ligand binding site [chemical binding]; other site 298653001110 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_9; cd08496 298653001111 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 298653001112 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 298653001113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653001114 dimer interface [polypeptide binding]; other site 298653001115 conserved gate region; other site 298653001116 ABC-ATPase subunit interface; other site 298653001117 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 298653001118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653001119 dimer interface [polypeptide binding]; other site 298653001120 conserved gate region; other site 298653001121 putative PBP binding loops; other site 298653001122 ABC-ATPase subunit interface; other site 298653001123 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 298653001124 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 298653001125 Walker A/P-loop; other site 298653001126 ATP binding site [chemical binding]; other site 298653001127 Q-loop/lid; other site 298653001128 ABC transporter signature motif; other site 298653001129 Walker B; other site 298653001130 D-loop; other site 298653001131 H-loop/switch region; other site 298653001132 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 298653001133 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 298653001134 Walker A/P-loop; other site 298653001135 ATP binding site [chemical binding]; other site 298653001136 Q-loop/lid; other site 298653001137 ABC transporter signature motif; other site 298653001138 Walker B; other site 298653001139 D-loop; other site 298653001140 H-loop/switch region; other site 298653001141 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 298653001142 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 298653001143 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 298653001144 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 298653001145 inhibitor binding site; inhibition site 298653001146 active site 298653001147 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 298653001148 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 298653001149 active site 298653001150 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 298653001151 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 298653001152 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 298653001153 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 298653001154 Transcriptional regulators [Transcription]; Region: PurR; COG1609 298653001155 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 298653001156 DNA binding site [nucleotide binding] 298653001157 domain linker motif; other site 298653001158 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 298653001159 ligand binding site [chemical binding]; other site 298653001160 dimerization interface [polypeptide binding]; other site 298653001161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653001162 putative substrate translocation pore; other site 298653001163 Protein of unknown function (DUF433); Region: DUF433; pfam04255 298653001164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 298653001165 Integrase core domain; Region: rve; pfam00665 298653001166 Integrase core domain; Region: rve_3; pfam13683 298653001167 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 298653001168 oligomeric interface; other site 298653001169 putative active site [active] 298653001170 homodimer interface [polypeptide binding]; other site 298653001171 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 298653001172 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 298653001173 protein-splicing catalytic site; other site 298653001174 thioester formation/cholesterol transfer; other site 298653001175 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 298653001176 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 298653001177 active site 298653001178 catalytic tetrad [active] 298653001179 Transcriptional regulators [Transcription]; Region: PurR; COG1609 298653001180 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 298653001181 DNA binding site [nucleotide binding] 298653001182 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 298653001183 dimerization interface [polypeptide binding]; other site 298653001184 ligand binding site [chemical binding]; other site 298653001185 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_9; cd08496 298653001186 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 298653001187 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 298653001188 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653001189 dimer interface [polypeptide binding]; other site 298653001190 conserved gate region; other site 298653001191 putative PBP binding loops; other site 298653001192 ABC-ATPase subunit interface; other site 298653001193 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 298653001194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653001195 dimer interface [polypeptide binding]; other site 298653001196 conserved gate region; other site 298653001197 putative PBP binding loops; other site 298653001198 ABC-ATPase subunit interface; other site 298653001199 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 298653001200 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 298653001201 Walker A/P-loop; other site 298653001202 ATP binding site [chemical binding]; other site 298653001203 Q-loop/lid; other site 298653001204 ABC transporter signature motif; other site 298653001205 Walker B; other site 298653001206 D-loop; other site 298653001207 H-loop/switch region; other site 298653001208 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 298653001209 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 298653001210 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 298653001211 Walker A/P-loop; other site 298653001212 ATP binding site [chemical binding]; other site 298653001213 Q-loop/lid; other site 298653001214 ABC transporter signature motif; other site 298653001215 Walker B; other site 298653001216 D-loop; other site 298653001217 H-loop/switch region; other site 298653001218 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 298653001219 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 298653001220 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 298653001221 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 298653001222 Probable beta-xylosidase; Provisional; Region: PLN03080 298653001223 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 298653001224 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 298653001225 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 298653001226 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 298653001227 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 298653001228 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 298653001229 catalytic residues [active] 298653001230 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 298653001231 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 298653001232 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 298653001233 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 298653001234 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653001235 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 298653001236 putative ligand binding site [chemical binding]; other site 298653001237 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 298653001238 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 298653001239 NAD(P) binding site [chemical binding]; other site 298653001240 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 298653001241 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 298653001242 active site 298653001243 iron coordination sites [ion binding]; other site 298653001244 substrate binding pocket [chemical binding]; other site 298653001245 short chain dehydrogenase; Provisional; Region: PRK07041 298653001246 classical (c) SDRs; Region: SDR_c; cd05233 298653001247 NAD(P) binding site [chemical binding]; other site 298653001248 active site 298653001249 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653001250 putative transposase OrfB; Reviewed; Region: PHA02517 298653001251 Integrase core domain; Region: rve; pfam00665 298653001252 Integrase core domain; Region: rve_3; pfam13683 298653001253 Transposase; Region: DEDD_Tnp_IS110; pfam01548 298653001254 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 298653001255 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 298653001256 putative transposase OrfB; Reviewed; Region: PHA02517 298653001257 Integrase core domain; Region: rve; pfam00665 298653001258 Integrase core domain; Region: rve_3; pfam13683 298653001259 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 298653001260 Transposase [DNA replication, recombination, and repair]; Region: COG5421 298653001261 DDE domain; Region: DDE_Tnp_IS240; pfam13610 298653001262 putative transposase OrfB; Reviewed; Region: PHA02517 298653001263 Integrase core domain; Region: rve; pfam00665 298653001264 Integrase core domain; Region: rve_3; pfam13683 298653001265 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653001266 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653001267 acetoin reductases; Region: 23BDH; TIGR02415 298653001268 classical (c) SDRs; Region: SDR_c; cd05233 298653001269 NAD(P) binding site [chemical binding]; other site 298653001270 active site 298653001271 classical (c) SDRs; Region: SDR_c; cd05233 298653001272 acetoin reductases; Region: 23BDH; TIGR02415 298653001273 NAD(P) binding site [chemical binding]; other site 298653001274 active site 298653001275 Domain of unknown function (DUF385); Region: DUF385; pfam04075 298653001276 NmrA-like family; Region: NmrA; pfam05368 298653001277 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653001278 NAD(P) binding site [chemical binding]; other site 298653001279 active site 298653001280 Integrase core domain; Region: rve; pfam00665 298653001281 Integrase core domain; Region: rve_3; pfam13683 298653001282 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 298653001283 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 298653001284 DNA binding residues [nucleotide binding] 298653001285 putative dimer interface [polypeptide binding]; other site 298653001286 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 298653001287 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653001288 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 298653001289 Integrase core domain; Region: rve_3; cl15866 298653001290 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 298653001291 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 298653001292 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 298653001293 Integrase core domain; Region: rve_3; pfam13683 298653001294 Homeodomain-like domain; Region: HTH_32; pfam13565 298653001295 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 298653001296 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 298653001297 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 298653001298 DNA binding residues [nucleotide binding] 298653001299 Integrase core domain; Region: rve_3; pfam13683 298653001300 Cupin domain; Region: Cupin_2; cl09118 298653001301 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 298653001302 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 298653001303 Walker A/P-loop; other site 298653001304 ATP binding site [chemical binding]; other site 298653001305 Q-loop/lid; other site 298653001306 ABC transporter signature motif; other site 298653001307 Walker B; other site 298653001308 D-loop; other site 298653001309 H-loop/switch region; other site 298653001310 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 298653001311 FtsX-like permease family; Region: FtsX; pfam02687 298653001312 SWIM zinc finger; Region: SWIM; cl15408 298653001313 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 298653001314 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 298653001315 ATP binding site [chemical binding]; other site 298653001316 putative Mg++ binding site [ion binding]; other site 298653001317 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 298653001318 nucleotide binding region [chemical binding]; other site 298653001319 ATP-binding site [chemical binding]; other site 298653001320 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 298653001321 Acyltransferase family; Region: Acyl_transf_3; pfam01757 298653001322 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 298653001323 PAS fold; Region: PAS_3; pfam08447 298653001324 putative active site [active] 298653001325 heme pocket [chemical binding]; other site 298653001326 GAF domain; Region: GAF; cl15785 298653001327 GAF domain; Region: GAF_2; pfam13185 298653001328 GAF domain; Region: GAF; pfam01590 298653001329 Histidine kinase; Region: HisKA_3; pfam07730 298653001330 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653001331 metal binding site [ion binding]; metal-binding site 298653001332 active site 298653001333 I-site; other site 298653001334 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 298653001335 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 298653001336 GAF domain; Region: GAF; pfam01590 298653001337 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653001338 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 298653001339 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 298653001340 active site 298653001341 iron coordination sites [ion binding]; other site 298653001342 substrate binding pocket [chemical binding]; other site 298653001343 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 298653001344 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653001345 classical (c) SDRs; Region: SDR_c; cd05233 298653001346 NAD(P) binding site [chemical binding]; other site 298653001347 active site 298653001348 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 298653001349 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653001350 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 298653001351 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 298653001352 SnoaL-like domain; Region: SnoaL_4; pfam13577 298653001353 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653001354 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 298653001355 putative ligand binding site [chemical binding]; other site 298653001356 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 298653001357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653001358 active site 298653001359 phosphorylation site [posttranslational modification] 298653001360 intermolecular recognition site; other site 298653001361 dimerization interface [polypeptide binding]; other site 298653001362 HTH domain; Region: HTH_11; pfam08279 298653001363 DNA-binding site [nucleotide binding]; DNA binding site 298653001364 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 298653001365 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 298653001366 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 298653001367 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 298653001368 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 298653001369 FOG: WD40 repeat [General function prediction only]; Region: COG2319 298653001370 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 298653001371 structural tetrad; other site 298653001372 Lsr2; Region: Lsr2; pfam11774 298653001373 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 298653001374 Histidine kinase; Region: HisKA_3; pfam07730 298653001375 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653001376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653001377 active site 298653001378 phosphorylation site [posttranslational modification] 298653001379 intermolecular recognition site; other site 298653001380 dimerization interface [polypeptide binding]; other site 298653001381 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653001382 DNA binding residues [nucleotide binding] 298653001383 dimerization interface [polypeptide binding]; other site 298653001384 FtsX-like permease family; Region: FtsX; pfam02687 298653001385 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 298653001386 FtsX-like permease family; Region: FtsX; pfam02687 298653001387 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 298653001388 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 298653001389 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 298653001390 Walker A/P-loop; other site 298653001391 ATP binding site [chemical binding]; other site 298653001392 Q-loop/lid; other site 298653001393 ABC transporter signature motif; other site 298653001394 Walker B; other site 298653001395 D-loop; other site 298653001396 H-loop/switch region; other site 298653001397 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 298653001398 Histidine kinase; Region: HisKA_3; pfam07730 298653001399 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653001400 ATP binding site [chemical binding]; other site 298653001401 Mg2+ binding site [ion binding]; other site 298653001402 G-X-G motif; other site 298653001403 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653001404 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653001405 active site 298653001406 phosphorylation site [posttranslational modification] 298653001407 intermolecular recognition site; other site 298653001408 dimerization interface [polypeptide binding]; other site 298653001409 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653001410 DNA binding residues [nucleotide binding] 298653001411 dimerization interface [polypeptide binding]; other site 298653001412 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 298653001413 Integrase core domain; Region: rve; pfam00665 298653001414 GAF domain; Region: GAF_2; pfam13185 298653001415 GAF domain; Region: GAF; pfam01590 298653001416 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 298653001417 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 298653001418 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 298653001419 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 298653001420 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 298653001421 active site 298653001422 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 298653001423 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 298653001424 putative ADP-binding pocket [chemical binding]; other site 298653001425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653001426 putative substrate translocation pore; other site 298653001427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653001428 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 298653001429 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653001430 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653001431 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653001432 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653001433 DNA binding residues [nucleotide binding] 298653001434 dimerization interface [polypeptide binding]; other site 298653001435 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 298653001436 oligomeric interface; other site 298653001437 putative active site [active] 298653001438 homodimer interface [polypeptide binding]; other site 298653001439 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 298653001440 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653001441 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 298653001442 putative ligand binding site [chemical binding]; other site 298653001443 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653001444 Transposase [DNA replication, recombination, and repair]; Region: COG5421 298653001445 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 298653001446 DNA-binding site [nucleotide binding]; DNA binding site 298653001447 RNA-binding motif; other site 298653001448 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653001449 metal binding site [ion binding]; metal-binding site 298653001450 active site 298653001451 I-site; other site 298653001452 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 298653001453 dimerization interface [polypeptide binding]; other site 298653001454 putative DNA binding site [nucleotide binding]; other site 298653001455 putative Zn2+ binding site [ion binding]; other site 298653001456 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 298653001457 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 298653001458 putative metal binding site [ion binding]; other site 298653001459 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 298653001460 amphipathic channel; other site 298653001461 Asn-Pro-Ala signature motifs; other site 298653001462 Low molecular weight phosphatase family; Region: LMWPc; cd00115 298653001463 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 298653001464 active site 298653001465 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 298653001466 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 298653001467 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 298653001468 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 298653001469 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 298653001470 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 298653001471 motif II; other site 298653001472 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 298653001473 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 298653001474 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 298653001475 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 298653001476 DNA binding site [nucleotide binding] 298653001477 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 298653001478 FOG: WD40 repeat [General function prediction only]; Region: COG2319 298653001479 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 298653001480 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 298653001481 structural tetrad; other site 298653001482 FOG: WD40 repeat [General function prediction only]; Region: COG2319 298653001483 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 298653001484 structural tetrad; other site 298653001485 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 298653001486 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653001487 metal binding site [ion binding]; metal-binding site 298653001488 active site 298653001489 I-site; other site 298653001490 tetracycline repressor protein TetR; Provisional; Region: PRK13756 298653001491 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653001492 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 298653001493 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653001494 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653001495 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 298653001496 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653001497 NAD(P) binding site [chemical binding]; other site 298653001498 active site 298653001499 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 298653001500 Amidohydrolase; Region: Amidohydro_2; pfam04909 298653001501 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653001502 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 298653001503 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 298653001504 active site 298653001505 catalytic tetrad [active] 298653001506 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 298653001507 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 298653001508 NAD(P) binding site [chemical binding]; other site 298653001509 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 298653001510 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 298653001511 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 298653001512 molybdopterin cofactor binding site; other site 298653001513 Molydopterin dinucleotide binding domain; Region: Molydop_binding; pfam01568 298653001514 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653001515 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 298653001516 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 298653001517 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 298653001518 catalytic residues [active] 298653001519 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 298653001520 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653001521 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653001522 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653001523 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653001524 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 298653001525 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 298653001526 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 298653001527 Ligand Binding Site [chemical binding]; other site 298653001528 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 298653001529 dimer interface [polypeptide binding]; other site 298653001530 phosphorylation site [posttranslational modification] 298653001531 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653001532 ATP binding site [chemical binding]; other site 298653001533 Mg2+ binding site [ion binding]; other site 298653001534 G-X-G motif; other site 298653001535 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 298653001536 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 298653001537 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 298653001538 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 298653001539 K+-transporting ATPase, c chain; Region: KdpC; cl00944 298653001540 K+-transporting ATPase, c chain; Region: KdpC; cl00944 298653001541 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653001542 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 298653001543 putative ligand binding site [chemical binding]; other site 298653001544 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 298653001545 Dienelactone hydrolase family; Region: DLH; pfam01738 298653001546 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653001547 diaminopimelate decarboxylase; Region: lysA; TIGR01048 298653001548 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 298653001549 active site 298653001550 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 298653001551 substrate binding site [chemical binding]; other site 298653001552 catalytic residues [active] 298653001553 dimer interface [polypeptide binding]; other site 298653001554 Survival protein SurE; Region: SurE; cl00448 298653001555 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 298653001556 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 298653001557 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653001558 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653001559 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653001560 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 298653001561 DUF35 OB-fold domain; Region: DUF35; pfam01796 298653001562 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 298653001563 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 298653001564 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 298653001565 NAD binding site [chemical binding]; other site 298653001566 catalytic residues [active] 298653001567 Amidohydrolase; Region: Amidohydro_2; pfam04909 298653001568 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 298653001569 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 298653001570 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653001571 classical (c) SDRs; Region: SDR_c; cd05233 298653001572 NAD(P) binding site [chemical binding]; other site 298653001573 active site 298653001574 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653001575 Domain of unknown function (DUF385); Region: DUF385; pfam04075 298653001576 Phosphotransferase enzyme family; Region: APH; pfam01636 298653001577 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 298653001578 putative active site [active] 298653001579 putative substrate binding site [chemical binding]; other site 298653001580 ATP binding site [chemical binding]; other site 298653001581 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 298653001582 Phosphotransferase enzyme family; Region: APH; pfam01636 298653001583 substrate binding site [chemical binding]; other site 298653001584 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653001585 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653001586 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653001587 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 298653001588 substrate binding site [chemical binding]; other site 298653001589 metal binding site [ion binding]; metal-binding site 298653001590 dimer interface [polypeptide binding]; other site 298653001591 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 298653001592 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 298653001593 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653001594 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653001595 active site 298653001596 ATP binding site [chemical binding]; other site 298653001597 substrate binding site [chemical binding]; other site 298653001598 activation loop (A-loop); other site 298653001599 MoxR-like ATPases [General function prediction only]; Region: COG0714 298653001600 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 298653001601 Walker A motif; other site 298653001602 ATP binding site [chemical binding]; other site 298653001603 Walker B motif; other site 298653001604 arginine finger; other site 298653001605 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 298653001606 Protein of unknown function DUF58; Region: DUF58; pfam01882 298653001607 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 298653001608 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 298653001609 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 298653001610 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 298653001611 active site 298653001612 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 298653001613 catalytic triad [active] 298653001614 dimer interface [polypeptide binding]; other site 298653001615 Amidohydrolase; Region: Amidohydro_2; pfam04909 298653001616 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 298653001617 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653001618 substrate binding site [chemical binding]; other site 298653001619 oxyanion hole (OAH) forming residues; other site 298653001620 trimer interface [polypeptide binding]; other site 298653001621 Transposase IS200 like; Region: Y1_Tnp; pfam01797 298653001622 Probable transposase; Region: OrfB_IS605; pfam01385 298653001623 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 298653001624 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653001625 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653001626 active site 298653001627 ATP binding site [chemical binding]; other site 298653001628 substrate binding site [chemical binding]; other site 298653001629 activation loop (A-loop); other site 298653001630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 298653001631 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 298653001632 glycine dehydrogenase; Provisional; Region: PRK05367 298653001633 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 298653001634 tetramer interface [polypeptide binding]; other site 298653001635 pyridoxal 5'-phosphate binding site [chemical binding]; other site 298653001636 catalytic residue [active] 298653001637 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 298653001638 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 298653001639 catalytic residue [active] 298653001640 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 298653001641 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 298653001642 putative active site [active] 298653001643 putative catalytic site [active] 298653001644 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653001645 S-adenosylmethionine binding site [chemical binding]; other site 298653001646 MMPL family; Region: MMPL; pfam03176 298653001647 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 298653001648 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653001649 metal binding site [ion binding]; metal-binding site 298653001650 active site 298653001651 I-site; other site 298653001652 tRNA synthetases class I (C) catalytic domain; Region: tRNA-synt_1e; pfam01406 298653001653 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 298653001654 active site 298653001655 HIGH motif; other site 298653001656 nucleotide binding site [chemical binding]; other site 298653001657 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 298653001658 active site 298653001659 KMSKS motif; other site 298653001660 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 298653001661 MMPL family; Region: MMPL; pfam03176 298653001662 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 298653001663 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 298653001664 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 298653001665 IucA / IucC family; Region: IucA_IucC; pfam04183 298653001666 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 298653001667 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 298653001668 IucA / IucC family; Region: IucA_IucC; pfam04183 298653001669 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 298653001670 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 298653001671 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 298653001672 catalytic residue [active] 298653001673 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 298653001674 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 298653001675 inhibitor-cofactor binding pocket; inhibition site 298653001676 pyridoxal 5'-phosphate binding site [chemical binding]; other site 298653001677 catalytic residue [active] 298653001678 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 298653001679 dimer interface [polypeptide binding]; other site 298653001680 active site 298653001681 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 298653001682 catalytic residues [active] 298653001683 substrate binding site [chemical binding]; other site 298653001684 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 298653001685 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 298653001686 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 298653001687 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 298653001688 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 298653001689 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 298653001690 dimerization interface [polypeptide binding]; other site 298653001691 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 298653001692 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 298653001693 dimerization interface [polypeptide binding]; other site 298653001694 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 298653001695 dimerization interface [polypeptide binding]; other site 298653001696 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 298653001697 dimerization interface [polypeptide binding]; other site 298653001698 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 298653001699 dimerization interface [polypeptide binding]; other site 298653001700 GAF domain; Region: GAF_2; pfam13185 298653001701 GAF domain; Region: GAF; pfam01590 298653001702 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 298653001703 dimer interface [polypeptide binding]; other site 298653001704 phosphorylation site [posttranslational modification] 298653001705 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653001706 ATP binding site [chemical binding]; other site 298653001707 Mg2+ binding site [ion binding]; other site 298653001708 G-X-G motif; other site 298653001709 Response regulator receiver domain; Region: Response_reg; pfam00072 298653001710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653001711 active site 298653001712 phosphorylation site [posttranslational modification] 298653001713 intermolecular recognition site; other site 298653001714 dimerization interface [polypeptide binding]; other site 298653001715 Response regulator receiver domain; Region: Response_reg; pfam00072 298653001716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653001717 active site 298653001718 phosphorylation site [posttranslational modification] 298653001719 intermolecular recognition site; other site 298653001720 dimerization interface [polypeptide binding]; other site 298653001721 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 298653001722 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653001723 active site 298653001724 ATP binding site [chemical binding]; other site 298653001725 substrate binding site [chemical binding]; other site 298653001726 activation loop (A-loop); other site 298653001727 FOG: WD40 repeat [General function prediction only]; Region: COG2319 298653001728 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 298653001729 structural tetrad; other site 298653001730 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 298653001731 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653001732 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 298653001733 MarR family; Region: MarR; pfam01047 298653001734 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 298653001735 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 298653001736 putative homodimer interface [polypeptide binding]; other site 298653001737 putative homotetramer interface [polypeptide binding]; other site 298653001738 putative allosteric switch controlling residues; other site 298653001739 putative metal binding site [ion binding]; other site 298653001740 putative homodimer-homodimer interface [polypeptide binding]; other site 298653001741 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 298653001742 anti sigma factor interaction site; other site 298653001743 regulatory phosphorylation site [posttranslational modification]; other site 298653001744 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 298653001745 Amidase; Region: Amidase; cl11426 298653001746 Isochorismatase family; Region: Isochorismatase; pfam00857 298653001747 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 298653001748 catalytic triad [active] 298653001749 conserved cis-peptide bond; other site 298653001750 Transcriptional regulators [Transcription]; Region: GntR; COG1802 298653001751 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 298653001752 DNA-binding site [nucleotide binding]; DNA binding site 298653001753 FCD domain; Region: FCD; pfam07729 298653001754 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653001755 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 298653001756 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 298653001757 catalytic residues [active] 298653001758 catalytic nucleophile [active] 298653001759 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 298653001760 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 298653001761 Probable transposase; Region: OrfB_IS605; pfam01385 298653001762 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 298653001763 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 298653001764 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 298653001765 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 298653001766 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 298653001767 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 298653001768 active site 298653001769 tetramer interface; other site 298653001770 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 298653001771 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 298653001772 dimer interface [polypeptide binding]; other site 298653001773 putative functional site; other site 298653001774 putative MPT binding site; other site 298653001775 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 298653001776 trimer interface [polypeptide binding]; other site 298653001777 dimer interface [polypeptide binding]; other site 298653001778 putative active site [active] 298653001779 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 298653001780 MPT binding site; other site 298653001781 trimer interface [polypeptide binding]; other site 298653001782 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 298653001783 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 298653001784 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653001785 AAA domain; Region: AAA_33; pfam13671 298653001786 active site 298653001787 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 298653001788 active site 298653001789 NTP binding site [chemical binding]; other site 298653001790 metal binding triad [ion binding]; metal-binding site 298653001791 antibiotic binding site [chemical binding]; other site 298653001792 Protein of unknown function DUF86; Region: DUF86; cl01031 298653001793 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 298653001794 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653001795 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 298653001796 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 298653001797 active site 298653001798 catalytic tetrad [active] 298653001799 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653001800 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653001801 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653001802 NAD(P) binding site [chemical binding]; other site 298653001803 active site 298653001804 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653001805 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653001806 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 298653001807 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653001808 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 298653001809 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 298653001810 putative DNA binding site [nucleotide binding]; other site 298653001811 putative Zn2+ binding site [ion binding]; other site 298653001812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 298653001813 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 298653001814 Necrosis inducing protein (NPP1); Region: NPP1; pfam05630 298653001815 Amidohydrolase; Region: Amidohydro_2; pfam04909 298653001816 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653001817 Cupin domain; Region: Cupin_2; cl09118 298653001818 Helix-turn-helix domain; Region: HTH_18; pfam12833 298653001819 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 298653001820 Helix-turn-helix domains; Region: HTH; cl00088 298653001821 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 298653001822 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 298653001823 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 298653001824 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 298653001825 active site 298653001826 iron coordination sites [ion binding]; other site 298653001827 substrate binding pocket [chemical binding]; other site 298653001828 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 298653001829 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 298653001830 substrate binding pocket [chemical binding]; other site 298653001831 membrane-bound complex binding site; other site 298653001832 hinge residues; other site 298653001833 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 298653001834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 298653001835 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 298653001836 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 298653001837 Walker A/P-loop; other site 298653001838 ATP binding site [chemical binding]; other site 298653001839 Q-loop/lid; other site 298653001840 ABC transporter signature motif; other site 298653001841 Walker B; other site 298653001842 D-loop; other site 298653001843 H-loop/switch region; other site 298653001844 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 298653001845 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 298653001846 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 298653001847 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653001848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 298653001849 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 298653001850 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 298653001851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 298653001852 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653001853 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 298653001854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653001855 Major Facilitator Superfamily; Region: MFS_1; pfam07690 298653001856 putative substrate translocation pore; other site 298653001857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653001858 Isochorismatase family; Region: Isochorismatase; pfam00857 298653001859 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 298653001860 catalytic triad [active] 298653001861 conserved cis-peptide bond; other site 298653001862 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 298653001863 YceI-like domain; Region: YceI; pfam04264 298653001864 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 298653001865 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 298653001866 Sulfate transporter family; Region: Sulfate_transp; cl15842 298653001867 Sulfate transporter family; Region: Sulfate_transp; pfam00916 298653001868 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 298653001869 Domain of unknown function (DUF305); Region: DUF305; pfam03713 298653001870 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 298653001871 phosphopeptide binding site; other site 298653001872 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 298653001873 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 298653001874 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 298653001875 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 298653001876 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 298653001877 putative SAM binding site [chemical binding]; other site 298653001878 putative homodimer interface [polypeptide binding]; other site 298653001879 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 298653001880 Pectate lyase; Region: Pec_lyase_C; cl01593 298653001881 Right handed beta helix region; Region: Beta_helix; pfam13229 298653001882 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 298653001883 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 298653001884 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 298653001885 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 298653001886 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 298653001887 Chain length determinant protein; Region: Wzz; cl15801 298653001888 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 298653001889 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 298653001890 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 298653001891 MatE; Region: MatE; cl10513 298653001892 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 298653001893 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 298653001894 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 298653001895 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 298653001896 active site 298653001897 substrate binding site [chemical binding]; other site 298653001898 trimer interface [polypeptide binding]; other site 298653001899 CoA binding site [chemical binding]; other site 298653001900 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 298653001901 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 298653001902 Probable Catalytic site; other site 298653001903 metal-binding site 298653001904 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 298653001905 trimer interface [polypeptide binding]; other site 298653001906 active site 298653001907 substrate binding site [chemical binding]; other site 298653001908 CoA binding site [chemical binding]; other site 298653001909 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 298653001910 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 298653001911 putative active site [active] 298653001912 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 298653001913 putative active site [active] 298653001914 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653001915 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 298653001916 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 298653001917 active site 298653001918 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 298653001919 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 298653001920 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 298653001921 active site 298653001922 HIGH motif; other site 298653001923 dimer interface [polypeptide binding]; other site 298653001924 KMSKS motif; other site 298653001925 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 298653001926 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 298653001927 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 298653001928 active site 298653001929 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 298653001930 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 298653001931 Substrate binding site; other site 298653001932 Mg++ binding site; other site 298653001933 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 298653001934 active site 298653001935 substrate binding site [chemical binding]; other site 298653001936 CoA binding site [chemical binding]; other site 298653001937 Fatty acid desaturase; Region: FA_desaturase; pfam00487 298653001938 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 298653001939 Di-iron ligands [ion binding]; other site 298653001940 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 298653001941 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 298653001942 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 298653001943 ABC transporter; Region: ABC_tran_2; pfam12848 298653001944 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 298653001945 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14614 298653001946 Asp23 family; Region: Asp23; pfam03780 298653001947 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 298653001948 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 298653001949 5S rRNA interface [nucleotide binding]; other site 298653001950 CTC domain interface [polypeptide binding]; other site 298653001951 L16 interface [polypeptide binding]; other site 298653001952 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 298653001953 putative active site [active] 298653001954 catalytic residue [active] 298653001955 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 298653001956 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 298653001957 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 298653001958 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 298653001959 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 298653001960 DXD motif; other site 298653001961 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 298653001962 active site 298653001963 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 298653001964 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 298653001965 active site 298653001966 catalytic residues [active] 298653001967 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 298653001968 extended (e) SDRs; Region: SDR_e; cd08946 298653001969 NAD(P) binding site [chemical binding]; other site 298653001970 active site 298653001971 substrate binding site [chemical binding]; other site 298653001972 Cupin domain; Region: Cupin_2; cl09118 298653001973 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 298653001974 Methyltransferase domain; Region: Methyltransf_23; pfam13489 298653001975 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653001976 S-adenosylmethionine binding site [chemical binding]; other site 298653001977 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 298653001978 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 298653001979 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 298653001980 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 298653001981 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 298653001982 classical (c) SDRs; Region: SDR_c; cd05233 298653001983 NAD(P) binding site [chemical binding]; other site 298653001984 active site 298653001985 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 298653001986 active site 298653001987 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 298653001988 Domain of unknown function (DUF2172); Region: DUF2172; pfam09940 298653001989 metal binding site [ion binding]; metal-binding site 298653001990 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 298653001991 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 298653001992 active site 298653001993 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 298653001994 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 298653001995 DNA binding residues [nucleotide binding] 298653001996 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 298653001997 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 298653001998 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 298653001999 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 298653002000 ATP binding site [chemical binding]; other site 298653002001 putative Mg++ binding site [ion binding]; other site 298653002002 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 298653002003 nucleotide binding region [chemical binding]; other site 298653002004 ATP-binding site [chemical binding]; other site 298653002005 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 298653002006 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 298653002007 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 298653002008 homodimer interface [polypeptide binding]; other site 298653002009 metal binding site [ion binding]; metal-binding site 298653002010 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs'; Region: NTP-PPase_MazG_Cterm; cd11529 298653002011 homodimer interface [polypeptide binding]; other site 298653002012 putative chemical substrate binding site [chemical binding]; other site 298653002013 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 298653002014 tandem repeat interface [polypeptide binding]; other site 298653002015 oligomer interface [polypeptide binding]; other site 298653002016 active site residues [active] 298653002017 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 298653002018 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 298653002019 tandem repeat interface [polypeptide binding]; other site 298653002020 oligomer interface [polypeptide binding]; other site 298653002021 active site residues [active] 298653002022 enolase; Provisional; Region: eno; PRK00077 298653002023 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 298653002024 dimer interface [polypeptide binding]; other site 298653002025 metal binding site [ion binding]; metal-binding site 298653002026 substrate binding pocket [chemical binding]; other site 298653002027 Septum formation initiator; Region: DivIC; pfam04977 298653002028 Protein of unknown function (DUF501); Region: DUF501; pfam04417 298653002029 exopolyphosphatase; Region: exo_poly_only; TIGR03706 298653002030 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 298653002031 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 298653002032 ligand binding site [chemical binding]; other site 298653002033 active site 298653002034 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 298653002035 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 298653002036 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 298653002037 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 298653002038 active site 298653002039 catalytic triad [active] 298653002040 oxyanion hole [active] 298653002041 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 298653002042 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653002043 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653002044 Predicted integral membrane protein (DUF2269); Region: DUF2269; cl02335 298653002045 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 298653002046 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 298653002047 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 298653002048 metal ion-dependent adhesion site (MIDAS); other site 298653002049 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 298653002050 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 298653002051 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 298653002052 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 298653002053 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 298653002054 hypothetical protein; Provisional; Region: PRK09256 298653002055 leucyl-tRNA synthetase, eubacterial and mitochondrial family; Region: leuS_bact; TIGR00396 298653002056 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 298653002057 active site 298653002058 HIGH motif; other site 298653002059 nucleotide binding site [chemical binding]; other site 298653002060 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 298653002061 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 298653002062 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 298653002063 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 298653002064 active site 298653002065 KMSKS motif; other site 298653002066 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 298653002067 tRNA binding surface [nucleotide binding]; other site 298653002068 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 298653002069 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 298653002070 catalytic residues [active] 298653002071 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 298653002072 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 298653002073 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 298653002074 active site 298653002075 substrate-binding site [chemical binding]; other site 298653002076 metal-binding site [ion binding] 298653002077 GTP binding site [chemical binding]; other site 298653002078 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 298653002079 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 298653002080 putative active site [active] 298653002081 PhoH-like protein; Region: PhoH; pfam02562 298653002082 methionine sulfoxide reductase A; Provisional; Region: PRK00058 298653002083 hypothetical protein; Reviewed; Region: PRK00024 298653002084 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 298653002085 MPN+ (JAMM) motif; other site 298653002086 Zinc-binding site [ion binding]; other site 298653002087 adenylate kinase; Reviewed; Region: adk; PRK00279 298653002088 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 298653002089 AMP-binding site [chemical binding]; other site 298653002090 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 298653002091 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 298653002092 nudix motif; other site 298653002093 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 298653002094 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 298653002095 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 298653002096 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 298653002097 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 298653002098 fumarate hydratase; Reviewed; Region: fumC; PRK00485 298653002099 aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596 298653002100 active sites [active] 298653002101 tetramer interface [polypeptide binding]; other site 298653002102 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 298653002103 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 298653002104 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 298653002105 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 298653002106 generic binding surface II; other site 298653002107 generic binding surface I; other site 298653002108 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 298653002109 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 298653002110 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 298653002111 putative active site [active] 298653002112 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 298653002113 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 298653002114 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 298653002115 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 298653002116 putative active site [active] 298653002117 putative metal binding site [ion binding]; other site 298653002118 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 298653002119 GTP-binding protein YchF; Reviewed; Region: PRK09601 298653002120 YchF GTPase; Region: YchF; cd01900 298653002121 G1 box; other site 298653002122 GTP/Mg2+ binding site [chemical binding]; other site 298653002123 Switch I region; other site 298653002124 G2 box; other site 298653002125 Switch II region; other site 298653002126 G3 box; other site 298653002127 G4 box; other site 298653002128 G5 box; other site 298653002129 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 298653002130 Protein of unknown function (DUF952); Region: DUF952; pfam06108 298653002131 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 298653002132 aromatic arch; other site 298653002133 DCoH dimer interaction site [polypeptide binding]; other site 298653002134 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 298653002135 DCoH tetramer interaction site [polypeptide binding]; other site 298653002136 substrate binding site [chemical binding]; other site 298653002137 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 298653002138 active site 298653002139 8-oxo-dGMP binding site [chemical binding]; other site 298653002140 nudix motif; other site 298653002141 metal binding site [ion binding]; metal-binding site 298653002142 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 298653002143 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 298653002144 G1 box; other site 298653002145 putative GEF interaction site [polypeptide binding]; other site 298653002146 GTP/Mg2+ binding site [chemical binding]; other site 298653002147 Switch I region; other site 298653002148 G2 box; other site 298653002149 G3 box; other site 298653002150 Switch II region; other site 298653002151 G4 box; other site 298653002152 G5 box; other site 298653002153 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 298653002154 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 298653002155 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 298653002156 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 298653002157 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 298653002158 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 298653002159 protein binding site [polypeptide binding]; other site 298653002160 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 298653002161 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 298653002162 Ferredoxin [Energy production and conversion]; Region: COG1146 298653002163 4Fe-4S binding domain; Region: Fer4; pfam00037 298653002164 succinyldiaminopimelate transaminase; Region: DapC_actino; TIGR03539 298653002165 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 298653002166 pyridoxal 5'-phosphate binding site [chemical binding]; other site 298653002167 homodimer interface [polypeptide binding]; other site 298653002168 catalytic residue [active] 298653002169 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 298653002170 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 298653002171 trimer interface [polypeptide binding]; other site 298653002172 active site 298653002173 substrate binding site [chemical binding]; other site 298653002174 CoA binding site [chemical binding]; other site 298653002175 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 298653002176 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 298653002177 metal binding site [ion binding]; metal-binding site 298653002178 putative dimer interface [polypeptide binding]; other site 298653002179 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 298653002180 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 298653002181 dihydropteroate synthase; Region: DHPS; TIGR01496 298653002182 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 298653002183 substrate binding pocket [chemical binding]; other site 298653002184 dimer interface [polypeptide binding]; other site 298653002185 inhibitor binding site; inhibition site 298653002186 DivIVA domain; Region: DivI1A_domain; TIGR03544 298653002187 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 298653002188 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 298653002189 multifunctional aminopeptidase A; Provisional; Region: PRK00913 298653002190 interface (dimer of trimers) [polypeptide binding]; other site 298653002191 Substrate-binding/catalytic site; other site 298653002192 Zn-binding sites [ion binding]; other site 298653002193 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 298653002194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653002195 S-adenosylmethionine binding site [chemical binding]; other site 298653002196 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 298653002197 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 298653002198 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 298653002199 DNA binding residues [nucleotide binding] 298653002200 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 298653002201 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 298653002202 sec-independent translocase; Provisional; Region: PRK01371 298653002203 Domain of unknown function DUF59; Region: DUF59; pfam01883 298653002204 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 298653002205 MarR family; Region: MarR; pfam01047 298653002206 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 298653002207 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653002208 AAA domain; Region: AAA_23; pfam13476 298653002209 Walker A/P-loop; other site 298653002210 ATP binding site [chemical binding]; other site 298653002211 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653002212 ABC transporter signature motif; other site 298653002213 Walker B; other site 298653002214 D-loop; other site 298653002215 H-loop/switch region; other site 298653002216 PhoD-like phosphatase; Region: PhoD; pfam09423 298653002217 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 298653002218 putative active site [active] 298653002219 putative metal binding site [ion binding]; other site 298653002220 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 298653002221 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 298653002222 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 298653002223 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 298653002224 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 298653002225 D-pathway; other site 298653002226 Putative ubiquinol binding site [chemical binding]; other site 298653002227 Low-spin heme (heme b) binding site [chemical binding]; other site 298653002228 Putative water exit pathway; other site 298653002229 Binuclear center (heme o3/CuB) [ion binding]; other site 298653002230 K-pathway; other site 298653002231 Putative proton exit pathway; other site 298653002232 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 298653002233 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 298653002234 inhibitor-cofactor binding pocket; inhibition site 298653002235 pyridoxal 5'-phosphate binding site [chemical binding]; other site 298653002236 catalytic residue [active] 298653002237 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 298653002238 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 298653002239 NAD(P) binding site [chemical binding]; other site 298653002240 catalytic residues [active] 298653002241 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 298653002242 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 298653002243 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 298653002244 putative metal binding site [ion binding]; other site 298653002245 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 298653002246 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 298653002247 putative metal binding site [ion binding]; other site 298653002248 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 298653002249 MgtE intracellular N domain; Region: MgtE_N; smart00924 298653002250 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 298653002251 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 298653002252 hypothetical protein; Provisional; Region: PRK07857 298653002253 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 298653002254 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 298653002255 Domain of unknown function (DUF397); Region: DUF397; pfam04149 298653002256 Domain of unknown function (DUF397); Region: DUF397; pfam04149 298653002257 Helix-turn-helix domain; Region: HTH_31; pfam13560 298653002258 hypothetical protein; Provisional; Region: PRK08912 298653002259 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 298653002260 pyridoxal 5'-phosphate binding site [chemical binding]; other site 298653002261 homodimer interface [polypeptide binding]; other site 298653002262 catalytic residue [active] 298653002263 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 298653002264 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 298653002265 Domain of unknown function DUF21; Region: DUF21; pfam01595 298653002266 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 298653002267 Domain of unknown function DUF21; Region: DUF21; pfam01595 298653002268 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 298653002269 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 298653002270 Transporter associated domain; Region: CorC_HlyC; smart01091 298653002271 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 298653002272 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 298653002273 P-loop; other site 298653002274 Magnesium ion binding site [ion binding]; other site 298653002275 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 298653002276 Magnesium ion binding site [ion binding]; other site 298653002277 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 298653002278 DEAD-like helicases superfamily; Region: DEXDc; smart00487 298653002279 ATP binding site [chemical binding]; other site 298653002280 Mg++ binding site [ion binding]; other site 298653002281 motif III; other site 298653002282 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 298653002283 nucleotide binding region [chemical binding]; other site 298653002284 ATP-binding site [chemical binding]; other site 298653002285 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 298653002286 dinuclear metal binding motif [ion binding]; other site 298653002287 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 298653002288 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653002289 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653002290 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 298653002291 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 298653002292 putative DNA binding site [nucleotide binding]; other site 298653002293 putative homodimer interface [polypeptide binding]; other site 298653002294 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 298653002295 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 298653002296 ATP binding site [chemical binding]; other site 298653002297 substrate interface [chemical binding]; other site 298653002298 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 298653002299 active site residue [active] 298653002300 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 298653002301 DNA binding site [nucleotide binding] 298653002302 active site 298653002303 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653002304 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653002305 NAD(P) binding site [chemical binding]; other site 298653002306 active site 298653002307 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 298653002308 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 298653002309 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653002310 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 298653002311 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 298653002312 Family description; Region: UvrD_C_2; cl15862 298653002313 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 298653002314 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653002315 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653002316 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 298653002317 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 298653002318 active site 298653002319 catalytic tetrad [active] 298653002320 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 298653002321 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 298653002322 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 298653002323 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 298653002324 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 298653002325 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 298653002326 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 298653002327 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 298653002328 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 298653002329 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 298653002330 catalytic residues [active] 298653002331 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 298653002332 Part of AAA domain; Region: AAA_19; pfam13245 298653002333 Family description; Region: UvrD_C_2; pfam13538 298653002334 HRDC domain; Region: HRDC; pfam00570 298653002335 Transcription factor WhiB; Region: Whib; pfam02467 298653002336 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 298653002337 Sulfatase; Region: Sulfatase; cl10460 298653002338 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 298653002339 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 298653002340 ATP binding site [chemical binding]; other site 298653002341 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 298653002342 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 298653002343 MoaE homodimer interface [polypeptide binding]; other site 298653002344 MoaD interaction [polypeptide binding]; other site 298653002345 active site residues [active] 298653002346 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 298653002347 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 298653002348 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 298653002349 hypothetical protein; Validated; Region: PRK00068 298653002350 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 298653002351 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 298653002352 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 298653002353 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653002354 Walker A/P-loop; other site 298653002355 ATP binding site [chemical binding]; other site 298653002356 Q-loop/lid; other site 298653002357 ABC transporter signature motif; other site 298653002358 Walker B; other site 298653002359 D-loop; other site 298653002360 H-loop/switch region; other site 298653002361 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 298653002362 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 298653002363 AsnC family; Region: AsnC_trans_reg; pfam01037 298653002364 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 298653002365 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 298653002366 inhibitor-cofactor binding pocket; inhibition site 298653002367 pyridoxal 5'-phosphate binding site [chemical binding]; other site 298653002368 catalytic residue [active] 298653002369 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653002370 FAD dependent oxidoreductase; Region: DAO; pfam01266 298653002371 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 298653002372 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 298653002373 tetrameric interface [polypeptide binding]; other site 298653002374 NAD binding site [chemical binding]; other site 298653002375 catalytic residues [active] 298653002376 substrate binding site [chemical binding]; other site 298653002377 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653002378 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653002379 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653002380 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 298653002381 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 298653002382 active site 298653002383 catalytic site [active] 298653002384 metal binding site [ion binding]; metal-binding site 298653002385 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 298653002386 active site 298653002387 ribosome small subunit-dependent GTPase A; Region: TIGR00157 298653002388 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 298653002389 GTPase/Zn-binding domain interface [polypeptide binding]; other site 298653002390 GTP/Mg2+ binding site [chemical binding]; other site 298653002391 G4 box; other site 298653002392 G1 box; other site 298653002393 Switch I region; other site 298653002394 G2 box; other site 298653002395 G3 box; other site 298653002396 Switch II region; other site 298653002397 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 298653002398 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 298653002399 hinge; other site 298653002400 active site 298653002401 Methyltransferase domain; Region: Methyltransf_11; pfam08241 298653002402 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 298653002403 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 298653002404 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 298653002405 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 298653002406 DNA binding residues [nucleotide binding] 298653002407 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 298653002408 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 298653002409 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653002410 NAD(P) binding site [chemical binding]; other site 298653002411 active site 298653002412 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 298653002413 carboxyltransferase (CT) interaction site; other site 298653002414 biotinylation site [posttranslational modification]; other site 298653002415 biotin synthase; Validated; Region: PRK06256 298653002416 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 298653002417 FeS/SAM binding site; other site 298653002418 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 298653002419 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 298653002420 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 298653002421 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 298653002422 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 298653002423 catalytic residue [active] 298653002424 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 298653002425 PAS domain; Region: PAS_9; pfam13426 298653002426 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 298653002427 Histidine kinase; Region: HisKA_2; pfam07568 298653002428 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653002429 ATP binding site [chemical binding]; other site 298653002430 Mg2+ binding site [ion binding]; other site 298653002431 G-X-G motif; other site 298653002432 Transcription factor WhiB; Region: Whib; pfam02467 298653002433 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 298653002434 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 298653002435 active site 298653002436 catalytic site [active] 298653002437 metal binding site [ion binding]; metal-binding site 298653002438 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 298653002439 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 298653002440 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 298653002441 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 298653002442 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 298653002443 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 298653002444 DNA binding residues [nucleotide binding] 298653002445 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 298653002446 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 298653002447 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 298653002448 Coenzyme A binding pocket [chemical binding]; other site 298653002449 Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055 298653002450 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 298653002451 Catalytic site [active] 298653002452 Cupin domain; Region: Cupin_2; cl09118 298653002453 Malic enzyme, N-terminal domain; Region: malic; pfam00390 298653002454 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653002455 NAD(P) binding pocket [chemical binding]; other site 298653002456 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 298653002457 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 298653002458 NAD(P) binding site [chemical binding]; other site 298653002459 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 298653002460 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 298653002461 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 298653002462 TPP-binding site [chemical binding]; other site 298653002463 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 298653002464 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 298653002465 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 298653002466 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 298653002467 thiamine monophosphate kinase; Provisional; Region: PRK05731 298653002468 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 298653002469 ATP binding site [chemical binding]; other site 298653002470 dimerization interface [polypeptide binding]; other site 298653002471 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 298653002472 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 298653002473 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 298653002474 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 298653002475 Part of AAA domain; Region: AAA_19; pfam13245 298653002476 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 298653002477 Family description; Region: UvrD_C_2; cl15862 298653002478 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 298653002479 putative active site [active] 298653002480 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 298653002481 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 298653002482 Family description; Region: UvrD_C_2; pfam13538 298653002483 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 298653002484 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 298653002485 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 298653002486 catalytic residue [active] 298653002487 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653002488 S-adenosylmethionine binding site [chemical binding]; other site 298653002489 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 298653002490 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653002491 metal binding site [ion binding]; metal-binding site 298653002492 active site 298653002493 I-site; other site 298653002494 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 298653002495 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653002496 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 298653002497 Patatin-like phospholipase; Region: Patatin; pfam01734 298653002498 nucleophile elbow; other site 298653002499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 298653002500 Response regulator receiver domain; Region: Response_reg; pfam00072 298653002501 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653002502 active site 298653002503 phosphorylation site [posttranslational modification] 298653002504 intermolecular recognition site; other site 298653002505 dimerization interface [polypeptide binding]; other site 298653002506 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 298653002507 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 298653002508 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 298653002509 active site 298653002510 HIGH motif; other site 298653002511 nucleotide binding site [chemical binding]; other site 298653002512 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 298653002513 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 298653002514 KMSK motif region; other site 298653002515 tRNA binding surface [nucleotide binding]; other site 298653002516 DALR anticodon binding domain; Region: DALR_1; smart00836 298653002517 anticodon binding site; other site 298653002518 homoserine dehydrogenase; Provisional; Region: PRK06349 298653002519 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 298653002520 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 298653002521 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 298653002522 threonine synthase; Reviewed; Region: PRK06721 298653002523 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 298653002524 homodimer interface [polypeptide binding]; other site 298653002525 pyridoxal 5'-phosphate binding site [chemical binding]; other site 298653002526 catalytic residue [active] 298653002527 homoserine kinase; Provisional; Region: PRK01212 298653002528 transcription termination factor Rho; Provisional; Region: PRK12608 298653002529 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 298653002530 RNA binding site [nucleotide binding]; other site 298653002531 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 298653002532 multimer interface [polypeptide binding]; other site 298653002533 Walker A motif; other site 298653002534 ATP binding site [chemical binding]; other site 298653002535 Walker B motif; other site 298653002536 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 298653002537 peptide chain release factor 1; Validated; Region: prfA; PRK00591 298653002538 This domain is found in peptide chain release factors; Region: PCRF; smart00937 298653002539 RF-1 domain; Region: RF-1; pfam00472 298653002540 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 298653002541 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653002542 S-adenosylmethionine binding site [chemical binding]; other site 298653002543 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 298653002544 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 298653002545 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 298653002546 dimer interface [polypeptide binding]; other site 298653002547 active site 298653002548 glycine-pyridoxal phosphate binding site [chemical binding]; other site 298653002549 folate binding site [chemical binding]; other site 298653002550 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 298653002551 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 298653002552 Mg++ binding site [ion binding]; other site 298653002553 putative catalytic motif [active] 298653002554 substrate binding site [chemical binding]; other site 298653002555 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 298653002556 ATP synthase subunit C; Region: ATP-synt_C; cl00466 298653002557 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 298653002558 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 298653002559 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 298653002560 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 298653002561 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 298653002562 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 298653002563 beta subunit interaction interface [polypeptide binding]; other site 298653002564 Walker A motif; other site 298653002565 ATP binding site [chemical binding]; other site 298653002566 Walker B motif; other site 298653002567 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 298653002568 F0F1 ATP synthase subunit gamma; Validated; Region: PRK05621 298653002569 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 298653002570 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 298653002571 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 298653002572 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 298653002573 alpha subunit interaction interface [polypeptide binding]; other site 298653002574 Walker A motif; other site 298653002575 ATP binding site [chemical binding]; other site 298653002576 Walker B motif; other site 298653002577 inhibitor binding site; inhibition site 298653002578 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 298653002579 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13442 298653002580 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 298653002581 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 298653002582 nudix motif; other site 298653002583 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 298653002584 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 298653002585 hinge; other site 298653002586 active site 298653002587 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 298653002588 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884 298653002589 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 298653002590 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 298653002591 B12 binding site [chemical binding]; other site 298653002592 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 298653002593 HD domain; Region: HD_4; pfam13328 298653002594 hypothetical protein; Provisional; Region: PRK03298 298653002595 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 298653002596 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 298653002597 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 298653002598 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 298653002599 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 298653002600 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 298653002601 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 298653002602 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 298653002603 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 298653002604 NAD(P) binding site [chemical binding]; other site 298653002605 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 298653002606 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 298653002607 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 298653002608 DNA binding residues [nucleotide binding] 298653002609 putative acyltransferase; Provisional; Region: PRK05790 298653002610 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 298653002611 dimer interface [polypeptide binding]; other site 298653002612 active site 298653002613 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 298653002614 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 298653002615 Walker A; other site 298653002616 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 298653002617 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 298653002618 dimer interface [polypeptide binding]; other site 298653002619 phosphorylation site [posttranslational modification] 298653002620 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653002621 ATP binding site [chemical binding]; other site 298653002622 Mg2+ binding site [ion binding]; other site 298653002623 G-X-G motif; other site 298653002624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653002625 Response regulator receiver domain; Region: Response_reg; pfam00072 298653002626 active site 298653002627 phosphorylation site [posttranslational modification] 298653002628 intermolecular recognition site; other site 298653002629 dimerization interface [polypeptide binding]; other site 298653002630 Domain of unknown function DUF77; Region: DUF77; pfam01910 298653002631 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 298653002632 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 298653002633 glycogen branching enzyme; Provisional; Region: PRK05402 298653002634 Carbohydrate-binding module 48 (Isoamylase N-terminal domain); Region: CBM_48; pfam02922 298653002635 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 298653002636 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 298653002637 active site 298653002638 catalytic site [active] 298653002639 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 298653002640 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 298653002641 trehalose synthase; Region: treS_nterm; TIGR02456 298653002642 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 298653002643 active site 298653002644 catalytic site [active] 298653002645 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 298653002646 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 298653002647 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 298653002648 active site 298653002649 homodimer interface [polypeptide binding]; other site 298653002650 catalytic site [active] 298653002651 acceptor binding site [chemical binding]; other site 298653002652 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 298653002653 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 298653002654 putative metal binding site [ion binding]; other site 298653002655 hypothetical protein; Provisional; Region: PRK14013 298653002656 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 298653002657 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 298653002658 putative metal binding site [ion binding]; other site 298653002659 GrpE; Region: GrpE; pfam01025 298653002660 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 298653002661 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 298653002662 nucleotide binding site [chemical binding]; other site 298653002663 putative NEF/HSP70 interaction site [polypeptide binding]; other site 298653002664 SBD interface [polypeptide binding]; other site 298653002665 Double zinc ribbon; Region: DZR; pfam12773 298653002666 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 298653002667 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 298653002668 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 298653002669 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 298653002670 nucleoside/Zn binding site; other site 298653002671 dimer interface [polypeptide binding]; other site 298653002672 catalytic motif [active] 298653002673 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 298653002674 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 298653002675 acetyl-CoA synthetase; Provisional; Region: PRK00174 298653002676 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 298653002677 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653002678 Domain of unknown function (DUF4009); Region: DUF4009; pfam13193 298653002679 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 298653002680 putative homodimer interface [polypeptide binding]; other site 298653002681 putative active site pocket [active] 298653002682 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 298653002683 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 298653002684 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 298653002685 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 298653002686 active site 298653002687 catalytic site [active] 298653002688 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653002689 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 298653002690 substrate binding site [chemical binding]; other site 298653002691 oxyanion hole (OAH) forming residues; other site 298653002692 trimer interface [polypeptide binding]; other site 298653002693 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 298653002694 putative catalytic site [active] 298653002695 putative metal binding site [ion binding]; other site 298653002696 putative phosphate binding site [ion binding]; other site 298653002697 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 298653002698 Ligand binding site [chemical binding]; other site 298653002699 Electron transfer flavoprotein domain; Region: ETF; pfam01012 298653002700 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 298653002701 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 298653002702 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 298653002703 Predicted transcriptional regulators [Transcription]; Region: COG1695 298653002704 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 298653002705 B12 binding site [chemical binding]; other site 298653002706 cobalt ligand [ion binding]; other site 298653002707 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653002708 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 298653002709 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884 298653002710 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 298653002711 MarR family; Region: MarR; pfam01047 298653002712 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 298653002713 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 298653002714 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 298653002715 catalytic residue [active] 298653002716 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 298653002717 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 298653002718 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 298653002719 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 298653002720 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 298653002721 nucleotide binding pocket [chemical binding]; other site 298653002722 K-X-D-G motif; other site 298653002723 catalytic site [active] 298653002724 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 298653002725 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 298653002726 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 298653002727 Dimer interface [polypeptide binding]; other site 298653002728 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653002729 metal binding site [ion binding]; metal-binding site 298653002730 active site 298653002731 I-site; other site 298653002732 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 298653002733 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 298653002734 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 298653002735 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 298653002736 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 298653002737 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 298653002738 GatB domain; Region: GatB_Yqey; smart00845 298653002739 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 298653002740 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 298653002741 active site 298653002742 metal binding site [ion binding]; metal-binding site 298653002743 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 298653002744 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 298653002745 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 298653002746 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 298653002747 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 298653002748 PYR/PP interface [polypeptide binding]; other site 298653002749 dimer interface [polypeptide binding]; other site 298653002750 TPP binding site [chemical binding]; other site 298653002751 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 298653002752 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 298653002753 TPP-binding site [chemical binding]; other site 298653002754 dimer interface [polypeptide binding]; other site 298653002755 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 298653002756 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 298653002757 putative valine binding site [chemical binding]; other site 298653002758 dimer interface [polypeptide binding]; other site 298653002759 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 298653002760 ketol-acid reductoisomerase; Provisional; Region: PRK05479 298653002761 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 298653002762 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 298653002763 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 298653002764 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; pfam02826 298653002765 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 298653002766 putative L-serine binding site [chemical binding]; other site 298653002767 Septum formation; Region: Septum_form; pfam13845 298653002768 2-isopropylmalate synthase, yeast type; Region: leuA_yeast; TIGR00970 298653002769 HMGL-like; Region: HMGL-like; pfam00682 298653002770 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 298653002771 Protein of unknown function (DUF1059); Region: DUF1059; pfam06348 298653002772 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 298653002773 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 298653002774 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 298653002775 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 298653002776 homodimer interface [polypeptide binding]; other site 298653002777 substrate-cofactor binding pocket; other site 298653002778 catalytic residue [active] 298653002779 FOG: CBS domain [General function prediction only]; Region: COG0517 298653002780 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_11; cd04624 298653002781 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 298653002782 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 298653002783 ligand binding site [chemical binding]; other site 298653002784 flexible hinge region; other site 298653002785 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 298653002786 putative switch regulator; other site 298653002787 non-specific DNA interactions [nucleotide binding]; other site 298653002788 DNA binding site [nucleotide binding] 298653002789 sequence specific DNA binding site [nucleotide binding]; other site 298653002790 putative cAMP binding site [chemical binding]; other site 298653002791 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 298653002792 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 298653002793 active site 298653002794 catalytic residues [active] 298653002795 metal binding site [ion binding]; metal-binding site 298653002796 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 298653002797 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 298653002798 N-acetyl-D-glucosamine binding site [chemical binding]; other site 298653002799 catalytic residue [active] 298653002800 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 298653002801 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 298653002802 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 298653002803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653002804 ATP binding site [chemical binding]; other site 298653002805 Mg2+ binding site [ion binding]; other site 298653002806 G-X-G motif; other site 298653002807 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653002808 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653002809 active site 298653002810 ATP binding site [chemical binding]; other site 298653002811 substrate binding site [chemical binding]; other site 298653002812 activation loop (A-loop); other site 298653002813 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 298653002814 Transcriptional regulator [Transcription]; Region: IclR; COG1414 298653002815 Bacterial transcriptional regulator; Region: IclR; pfam01614 298653002816 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 298653002817 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 298653002818 substrate binding site [chemical binding]; other site 298653002819 ligand binding site [chemical binding]; other site 298653002820 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 298653002821 substrate binding site [chemical binding]; other site 298653002822 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 298653002823 IHF dimer interface [polypeptide binding]; other site 298653002824 IHF - DNA interface [nucleotide binding]; other site 298653002825 polyphosphate kinase; Provisional; Region: PRK05443 298653002826 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 298653002827 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 298653002828 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 298653002829 putative domain interface [polypeptide binding]; other site 298653002830 putative active site [active] 298653002831 catalytic site [active] 298653002832 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 298653002833 putative active site [active] 298653002834 catalytic site [active] 298653002835 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 298653002836 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 298653002837 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 298653002838 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653002839 metal binding site [ion binding]; metal-binding site 298653002840 active site 298653002841 I-site; other site 298653002842 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 298653002843 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 298653002844 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 298653002845 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 298653002846 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 298653002847 putative acyl-acceptor binding pocket; other site 298653002848 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 298653002849 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 298653002850 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 298653002851 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653002852 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653002853 active site 298653002854 ATP binding site [chemical binding]; other site 298653002855 substrate binding site [chemical binding]; other site 298653002856 activation loop (A-loop); other site 298653002857 FOG: WD40 repeat [General function prediction only]; Region: COG2319 298653002858 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 298653002859 structural tetrad; other site 298653002860 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 298653002861 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 298653002862 hinge; other site 298653002863 active site 298653002864 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 298653002865 dimer interface [polypeptide binding]; other site 298653002866 substrate binding site [chemical binding]; other site 298653002867 ATP binding site [chemical binding]; other site 298653002868 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 298653002869 AsnC family; Region: AsnC_trans_reg; pfam01037 298653002870 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 298653002871 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 298653002872 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 298653002873 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 298653002874 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 298653002875 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 298653002876 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 298653002877 ssDNA binding site; other site 298653002878 generic binding surface II; other site 298653002879 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 298653002880 ATP binding site [chemical binding]; other site 298653002881 putative Mg++ binding site [ion binding]; other site 298653002882 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 298653002883 nucleotide binding region [chemical binding]; other site 298653002884 ATP-binding site [chemical binding]; other site 298653002885 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653002886 S-adenosylmethionine binding site [chemical binding]; other site 298653002887 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 298653002888 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 298653002889 active site 298653002890 (T/H)XGH motif; other site 298653002891 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 298653002892 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 298653002893 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 298653002894 ribonuclease III; Reviewed; Region: rnc; PRK00102 298653002895 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 298653002896 dimerization interface [polypeptide binding]; other site 298653002897 active site 298653002898 metal binding site [ion binding]; metal-binding site 298653002899 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 298653002900 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 298653002901 DNA binding site [nucleotide binding] 298653002902 putative catalytic residues [active] 298653002903 turnover-facilitating residue; other site 298653002904 intercalation triad [nucleotide binding]; other site 298653002905 8OG recognition residue [nucleotide binding]; other site 298653002906 putative reading head residues; other site 298653002907 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 298653002908 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 298653002909 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 298653002910 Acylphosphatase; Region: Acylphosphatase; cl00551 298653002911 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 298653002912 Walker A/P-loop; other site 298653002913 ATP binding site [chemical binding]; other site 298653002914 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 298653002915 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 298653002916 ABC transporter signature motif; other site 298653002917 Walker B; other site 298653002918 D-loop; other site 298653002919 H-loop/switch region; other site 298653002920 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 298653002921 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 298653002922 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653002923 signal recognition particle protein; Provisional; Region: PRK10867 298653002924 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 298653002925 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 298653002926 GTP binding site [chemical binding]; other site 298653002927 Signal peptide binding domain; Region: SRP_SPB; pfam02978 298653002928 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 298653002929 hypothetical protein; Provisional; Region: PRK02821 298653002930 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 298653002931 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 298653002932 RimM N-terminal domain; Region: RimM; pfam01782 298653002933 PRC-barrel domain; Region: PRC; pfam05239 298653002934 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 298653002935 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 298653002936 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 298653002937 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 298653002938 Catalytic site [active] 298653002939 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 298653002940 RNA/DNA hybrid binding site [nucleotide binding]; other site 298653002941 active site 298653002942 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 298653002943 hypothetical protein; Reviewed; Region: PRK12497 298653002944 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 298653002945 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 298653002946 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 298653002947 Walker A motif; other site 298653002948 ATP binding site [chemical binding]; other site 298653002949 Walker B motif; other site 298653002950 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 298653002951 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 298653002952 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 298653002953 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 298653002954 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 298653002955 active site 298653002956 DNA binding site [nucleotide binding] 298653002957 Int/Topo IB signature motif; other site 298653002958 Peptidase family M23; Region: Peptidase_M23; pfam01551 298653002959 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 298653002960 rRNA interaction site [nucleotide binding]; other site 298653002961 S8 interaction site; other site 298653002962 putative laminin-1 binding site; other site 298653002963 elongation factor Ts; Reviewed; Region: tsf; PRK12332 298653002964 UBA/TS-N domain; Region: UBA; pfam00627 298653002965 Elongation factor TS; Region: EF_TS; pfam00889 298653002966 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 298653002967 putative nucleotide binding site [chemical binding]; other site 298653002968 uridine monophosphate binding site [chemical binding]; other site 298653002969 homohexameric interface [polypeptide binding]; other site 298653002970 ribosome recycling factor; Reviewed; Region: frr; PRK00083 298653002971 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 298653002972 hinge region; other site 298653002973 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 298653002974 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 298653002975 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 298653002976 FeS/SAM binding site; other site 298653002977 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653002978 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 298653002979 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 298653002980 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 298653002981 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 298653002982 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 298653002983 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 298653002984 active site 298653002985 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 298653002986 protein binding site [polypeptide binding]; other site 298653002987 Peptidase family M50; Region: Peptidase_M50; pfam02163 298653002988 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 298653002989 putative substrate binding region [chemical binding]; other site 298653002990 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 298653002991 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 298653002992 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 298653002993 Predicted acetyltransferase [General function prediction only]; Region: COG3393 298653002994 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 298653002995 NMT1-like family; Region: NMT1_2; pfam13379 298653002996 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 298653002997 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 298653002998 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 298653002999 Walker A/P-loop; other site 298653003000 ATP binding site [chemical binding]; other site 298653003001 Q-loop/lid; other site 298653003002 ABC transporter signature motif; other site 298653003003 Walker B; other site 298653003004 D-loop; other site 298653003005 H-loop/switch region; other site 298653003006 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 298653003007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653003008 dimer interface [polypeptide binding]; other site 298653003009 conserved gate region; other site 298653003010 putative PBP binding loops; other site 298653003011 ABC-ATPase subunit interface; other site 298653003012 Predicted transcriptional regulator [Transcription]; Region: COG1959 298653003013 Transcriptional regulator; Region: Rrf2; pfam02082 298653003014 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 298653003015 nitrous-oxide reductase; Validated; Region: PRK02888 298653003016 Sm and related proteins; Region: Sm_like; cl00259 298653003017 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 298653003018 NusA N-terminal domain; Region: NusA_N; pfam08529 298653003019 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 298653003020 RNA binding site [nucleotide binding]; other site 298653003021 homodimer interface [polypeptide binding]; other site 298653003022 NusA-like KH domain; Region: KH_5; pfam13184 298653003023 G-X-X-G motif; other site 298653003024 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 298653003025 G-X-X-G motif; other site 298653003026 Protein of unknown function (DUF448); Region: DUF448; pfam04296 298653003027 putative RNA binding cleft [nucleotide binding]; other site 298653003028 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 298653003029 translation initiation factor IF-2; Region: IF-2; TIGR00487 298653003030 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 298653003031 G1 box; other site 298653003032 putative GEF interaction site [polypeptide binding]; other site 298653003033 GTP/Mg2+ binding site [chemical binding]; other site 298653003034 Switch I region; other site 298653003035 G2 box; other site 298653003036 G3 box; other site 298653003037 Switch II region; other site 298653003038 G4 box; other site 298653003039 G5 box; other site 298653003040 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 298653003041 Translation-initiation factor 2; Region: IF-2; pfam11987 298653003042 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 298653003043 Protein of unknown function (DUF503); Region: DUF503; pfam04456 298653003044 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 298653003045 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 298653003046 DHH family; Region: DHH; pfam01368 298653003047 DHHA1 domain; Region: DHHA1; pfam02272 298653003048 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 298653003049 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 298653003050 RNA binding site [nucleotide binding]; other site 298653003051 active site 298653003052 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 298653003053 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 298653003054 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 298653003055 active site 298653003056 Riboflavin kinase; Region: Flavokinase; smart00904 298653003057 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 298653003058 16S/18S rRNA binding site [nucleotide binding]; other site 298653003059 S13e-L30e interaction site [polypeptide binding]; other site 298653003060 25S rRNA binding site [nucleotide binding]; other site 298653003061 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 298653003062 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 298653003063 RNase E interface [polypeptide binding]; other site 298653003064 trimer interface [polypeptide binding]; other site 298653003065 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 298653003066 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 298653003067 RNase E interface [polypeptide binding]; other site 298653003068 trimer interface [polypeptide binding]; other site 298653003069 active site 298653003070 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 298653003071 putative nucleic acid binding region [nucleotide binding]; other site 298653003072 G-X-X-G motif; other site 298653003073 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 298653003074 RNA binding site [nucleotide binding]; other site 298653003075 domain interface; other site 298653003076 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 298653003077 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 298653003078 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 298653003079 dihydrodipicolinate reductase; Provisional; Region: PRK00048 298653003080 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 298653003081 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 298653003082 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 298653003083 Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077 298653003084 nucleotide binding site [chemical binding]; other site 298653003085 putative NEF/HSP70 interaction site [polypeptide binding]; other site 298653003086 SBD interface [polypeptide binding]; other site 298653003087 histidyl-tRNA synthetase; Region: hisS; TIGR00442 298653003088 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 298653003089 dimer interface [polypeptide binding]; other site 298653003090 motif 1; other site 298653003091 active site 298653003092 motif 2; other site 298653003093 motif 3; other site 298653003094 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 298653003095 putative phosphoketolase; Provisional; Region: PRK05261 298653003096 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 298653003097 TPP-binding site; other site 298653003098 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 298653003099 XFP C-terminal domain; Region: XFP_C; pfam09363 298653003100 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 298653003101 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 298653003102 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 298653003103 dimer interface [polypeptide binding]; other site 298653003104 active site 298653003105 catalytic residue [active] 298653003106 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 298653003107 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 298653003108 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 298653003109 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 298653003110 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 298653003111 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 298653003112 Walker A motif; other site 298653003113 ATP binding site [chemical binding]; other site 298653003114 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 298653003115 Helix-turn-helix domain; Region: HTH_25; pfam13413 298653003116 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 298653003117 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 298653003118 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 298653003119 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 298653003120 competence damage-inducible protein A; Provisional; Region: PRK00549 298653003121 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 298653003122 putative MPT binding site; other site 298653003123 Competence-damaged protein; Region: CinA; pfam02464 298653003124 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 298653003125 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 298653003126 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 298653003127 dimerization interface [polypeptide binding]; other site 298653003128 DPS ferroxidase diiron center [ion binding]; other site 298653003129 ion pore; other site 298653003130 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 298653003131 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 298653003132 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 298653003133 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 298653003134 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 298653003135 Transposase IS200 like; Region: Y1_Tnp; pfam01797 298653003136 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 298653003137 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 298653003138 Probable transposase; Region: OrfB_IS605; pfam01385 298653003139 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 298653003140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653003141 putative substrate translocation pore; other site 298653003142 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 298653003143 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 298653003144 ATP binding site [chemical binding]; other site 298653003145 putative Mg++ binding site [ion binding]; other site 298653003146 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 298653003147 nucleotide binding region [chemical binding]; other site 298653003148 ATP-binding site [chemical binding]; other site 298653003149 DEAD/H associated; Region: DEAD_assoc; pfam08494 298653003150 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 298653003151 recombinase A; Provisional; Region: recA; PRK09354 298653003152 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 298653003153 hexamer interface [polypeptide binding]; other site 298653003154 Walker A motif; other site 298653003155 ATP binding site [chemical binding]; other site 298653003156 Walker B motif; other site 298653003157 recombination regulator RecX; Reviewed; Region: recX; PRK00117 298653003158 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 298653003159 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 298653003160 Zn2+ binding site [ion binding]; other site 298653003161 Mg2+ binding site [ion binding]; other site 298653003162 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 298653003163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653003164 dimer interface [polypeptide binding]; other site 298653003165 conserved gate region; other site 298653003166 putative PBP binding loops; other site 298653003167 ABC-ATPase subunit interface; other site 298653003168 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 298653003169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653003170 dimer interface [polypeptide binding]; other site 298653003171 conserved gate region; other site 298653003172 putative PBP binding loops; other site 298653003173 ABC-ATPase subunit interface; other site 298653003174 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 298653003175 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 298653003176 substrate binding pocket [chemical binding]; other site 298653003177 membrane-bound complex binding site; other site 298653003178 hinge residues; other site 298653003179 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 298653003180 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 298653003181 Walker A/P-loop; other site 298653003182 ATP binding site [chemical binding]; other site 298653003183 Q-loop/lid; other site 298653003184 ABC transporter signature motif; other site 298653003185 Walker B; other site 298653003186 D-loop; other site 298653003187 H-loop/switch region; other site 298653003188 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 298653003189 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 298653003190 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 298653003191 FeS/SAM binding site; other site 298653003192 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 298653003193 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 298653003194 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653003195 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 298653003196 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 298653003197 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 298653003198 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 298653003199 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 298653003200 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 298653003201 HflX GTPase family; Region: HflX; cd01878 298653003202 G1 box; other site 298653003203 GTP/Mg2+ binding site [chemical binding]; other site 298653003204 Switch I region; other site 298653003205 G2 box; other site 298653003206 G3 box; other site 298653003207 Switch II region; other site 298653003208 G4 box; other site 298653003209 G5 box; other site 298653003210 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 298653003211 LexA repressor; Validated; Region: PRK00215 298653003212 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 298653003213 Catalytic site [active] 298653003214 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 298653003215 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 298653003216 ATP cone domain; Region: ATP-cone; pfam03477 298653003217 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 298653003218 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 298653003219 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 298653003220 active site 298653003221 dimer interface [polypeptide binding]; other site 298653003222 effector binding site; other site 298653003223 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 298653003224 TSCPD domain; Region: TSCPD; pfam12637 298653003225 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 298653003226 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 298653003227 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 298653003228 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 298653003229 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 298653003230 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 298653003231 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 298653003232 DNA binding residues [nucleotide binding] 298653003233 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653003234 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 298653003235 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 298653003236 active site 298653003237 Zn binding site [ion binding]; other site 298653003238 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 298653003239 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 298653003240 CoA binding domain; Region: CoA_binding_2; pfam13380 298653003241 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 298653003242 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 298653003243 PAS fold; Region: PAS_4; pfam08448 298653003244 PAS fold; Region: PAS_3; pfam08447 298653003245 GAF domain; Region: GAF_2; pfam13185 298653003246 GAF domain; Region: GAF; pfam01590 298653003247 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 298653003248 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 298653003249 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 298653003250 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653003251 Walker A/P-loop; other site 298653003252 ATP binding site [chemical binding]; other site 298653003253 Q-loop/lid; other site 298653003254 ABC transporter signature motif; other site 298653003255 Walker B; other site 298653003256 D-loop; other site 298653003257 H-loop/switch region; other site 298653003258 Lsr2; Region: Lsr2; pfam11774 298653003259 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 298653003260 proline aminopeptidase P II; Provisional; Region: PRK10879 298653003261 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 298653003262 active site 298653003263 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653003264 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 298653003265 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 298653003266 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 298653003267 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 298653003268 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 298653003269 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 298653003270 FeS/SAM binding site; other site 298653003271 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 298653003272 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 298653003273 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 298653003274 Walker A motif; other site 298653003275 ATP binding site [chemical binding]; other site 298653003276 Walker B motif; other site 298653003277 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653003278 Peptidase family M41; Region: Peptidase_M41; pfam01434 298653003279 H+ Antiporter protein; Region: 2A0121; TIGR00900 298653003280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653003281 putative substrate translocation pore; other site 298653003282 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 298653003283 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 298653003284 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 298653003285 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 298653003286 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 298653003287 dimer interface [polypeptide binding]; other site 298653003288 active site 298653003289 acyl carrier protein; Provisional; Region: acpP; PRK00982 298653003290 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 298653003291 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 298653003292 dimer interface [polypeptide binding]; other site 298653003293 active site 298653003294 CoA binding pocket [chemical binding]; other site 298653003295 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 298653003296 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 298653003297 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 298653003298 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 298653003299 N-acetyl-D-glucosamine binding site [chemical binding]; other site 298653003300 catalytic residue [active] 298653003301 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 298653003302 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 298653003303 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 298653003304 putative trimer interface [polypeptide binding]; other site 298653003305 putative CoA binding site [chemical binding]; other site 298653003306 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653003307 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 298653003308 NAD(P) binding site [chemical binding]; other site 298653003309 active site 298653003310 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 298653003311 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 298653003312 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 298653003313 NAD(P) binding site [chemical binding]; other site 298653003314 homodimer interface [polypeptide binding]; other site 298653003315 substrate binding site [chemical binding]; other site 298653003316 active site 298653003317 Chain length determinant protein; Region: Wzz; cl15801 298653003318 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 298653003319 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653003320 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 298653003321 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 298653003322 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 298653003323 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 298653003324 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 298653003325 4Fe-4S binding domain; Region: Fer4; pfam00037 298653003326 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 298653003327 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653003328 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 298653003329 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 298653003330 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 298653003331 putative Iron-sulfur protein interface [polypeptide binding]; other site 298653003332 proximal heme binding site [chemical binding]; other site 298653003333 distal heme binding site [chemical binding]; other site 298653003334 putative dimer interface [polypeptide binding]; other site 298653003335 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 298653003336 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 298653003337 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 298653003338 dimerization interface [polypeptide binding]; other site 298653003339 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 298653003340 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 298653003341 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 298653003342 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 298653003343 active site 298653003344 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 298653003345 putative metal binding site [ion binding]; other site 298653003346 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 298653003347 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 298653003348 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 298653003349 TM-ABC transporter signature motif; other site 298653003350 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 298653003351 TM-ABC transporter signature motif; other site 298653003352 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 298653003353 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 298653003354 Walker A/P-loop; other site 298653003355 ATP binding site [chemical binding]; other site 298653003356 Q-loop/lid; other site 298653003357 ABC transporter signature motif; other site 298653003358 Walker B; other site 298653003359 D-loop; other site 298653003360 H-loop/switch region; other site 298653003361 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 298653003362 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653003363 Walker A/P-loop; other site 298653003364 ATP binding site [chemical binding]; other site 298653003365 Q-loop/lid; other site 298653003366 ABC transporter signature motif; other site 298653003367 Walker B; other site 298653003368 D-loop; other site 298653003369 H-loop/switch region; other site 298653003370 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653003371 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 298653003372 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 298653003373 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 298653003374 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 298653003375 DNA binding residues [nucleotide binding] 298653003376 dimer interface [polypeptide binding]; other site 298653003377 [2Fe-2S] cluster binding site [ion binding]; other site 298653003378 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 298653003379 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 298653003380 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 298653003381 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 298653003382 dimer interface [polypeptide binding]; other site 298653003383 active site 298653003384 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653003385 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 298653003386 ATP binding site [chemical binding]; other site 298653003387 putative Mg++ binding site [ion binding]; other site 298653003388 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 298653003389 nucleotide binding region [chemical binding]; other site 298653003390 ATP-binding site [chemical binding]; other site 298653003391 Helicase associated domain (HA2); Region: HA2; pfam04408 298653003392 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 298653003393 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 298653003394 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 298653003395 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653003396 non-specific DNA binding site [nucleotide binding]; other site 298653003397 salt bridge; other site 298653003398 sequence-specific DNA binding site [nucleotide binding]; other site 298653003399 Domain of unknown function (DUF397); Region: DUF397; pfam04149 298653003400 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 298653003401 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 298653003402 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 298653003403 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 298653003404 P loop; other site 298653003405 P-loop; other site 298653003406 Nucleotide binding site [chemical binding]; other site 298653003407 Magnesium ion binding site [ion binding]; other site 298653003408 DTAP/Switch II; other site 298653003409 Switch I; other site 298653003410 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 298653003411 Magnesium ion binding site [ion binding]; other site 298653003412 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 298653003413 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653003414 active site 298653003415 ATP binding site [chemical binding]; other site 298653003416 substrate binding site [chemical binding]; other site 298653003417 activation loop (A-loop); other site 298653003418 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 298653003419 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 298653003420 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653003421 Walker A/P-loop; other site 298653003422 ATP binding site [chemical binding]; other site 298653003423 Q-loop/lid; other site 298653003424 ABC transporter signature motif; other site 298653003425 Walker B; other site 298653003426 D-loop; other site 298653003427 H-loop/switch region; other site 298653003428 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 298653003429 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 298653003430 putative active site [active] 298653003431 putative metal binding site [ion binding]; other site 298653003432 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 298653003433 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 298653003434 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 298653003435 DNA binding site [nucleotide binding] 298653003436 active site 298653003437 Int/Topo IB signature motif; other site 298653003438 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 298653003439 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 298653003440 putative active site [active] 298653003441 putative NTP binding site [chemical binding]; other site 298653003442 putative nucleic acid binding site [nucleotide binding]; other site 298653003443 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 298653003444 Transposase [DNA replication, recombination, and repair]; Region: COG5421 298653003445 PemK-like protein; Region: PemK; pfam02452 298653003446 Predicted transcriptional regulators [Transcription]; Region: COG1733 298653003447 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 298653003448 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 298653003449 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653003450 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 298653003451 ParB-like nuclease domain; Region: ParB; smart00470 298653003452 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 298653003453 nudix motif; other site 298653003454 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 298653003455 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653003456 non-specific DNA binding site [nucleotide binding]; other site 298653003457 salt bridge; other site 298653003458 sequence-specific DNA binding site [nucleotide binding]; other site 298653003459 Domain of unknown function (DUF397); Region: DUF397; pfam04149 298653003460 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 298653003461 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653003462 non-specific DNA binding site [nucleotide binding]; other site 298653003463 salt bridge; other site 298653003464 sequence-specific DNA binding site [nucleotide binding]; other site 298653003465 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653003466 active site 298653003467 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 298653003468 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 298653003469 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 298653003470 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 298653003471 LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793 298653003472 active site 298653003473 zinc binding site [ion binding]; other site 298653003474 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 298653003475 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 298653003476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653003477 S-adenosylmethionine binding site [chemical binding]; other site 298653003478 Recombinase; Region: Recombinase; pfam07508 298653003479 AAA-like domain; Region: AAA_10; pfam12846 298653003480 ABC-2 type transporter; Region: ABC2_membrane; cl11417 298653003481 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 298653003482 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 298653003483 Walker A/P-loop; other site 298653003484 ATP binding site [chemical binding]; other site 298653003485 Q-loop/lid; other site 298653003486 ABC transporter signature motif; other site 298653003487 Walker B; other site 298653003488 D-loop; other site 298653003489 H-loop/switch region; other site 298653003490 Predicted transcriptional regulators [Transcription]; Region: COG1725 298653003491 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 298653003492 DNA-binding site [nucleotide binding]; DNA binding site 298653003493 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 298653003494 RHS Repeat; Region: RHS_repeat; cl11982 298653003495 RHS Repeat; Region: RHS_repeat; cl11982 298653003496 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 298653003497 Helix-turn-helix domains; Region: HTH; cl00088 298653003498 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 298653003499 N-acetyl-D-glucosamine binding site [chemical binding]; other site 298653003500 catalytic residue [active] 298653003501 TrwC relaxase; Region: TrwC; pfam08751 298653003502 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 298653003503 AAA domain; Region: AAA_30; pfam13604 298653003504 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 298653003505 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 298653003506 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653003507 Walker A motif; other site 298653003508 ATP binding site [chemical binding]; other site 298653003509 Walker B motif; other site 298653003510 Bacterial transcriptional activator domain; Region: BTAD; smart01043 298653003511 Transposase, Mutator family; Region: Transposase_mut; pfam00872 298653003512 MULE transposase domain; Region: MULE; pfam10551 298653003513 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 298653003514 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 298653003515 putative active site [active] 298653003516 putative NTP binding site [chemical binding]; other site 298653003517 putative nucleic acid binding site [nucleotide binding]; other site 298653003518 Transposase, Mutator family; Region: Transposase_mut; pfam00872 298653003519 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817 298653003520 CRISPR-associated protein; Region: TIGR03986 298653003521 CRISPR-associated protein; Region: TIGR03986 298653003522 CRISPR-associated protein, TIGR03984 family; Region: TIGR03984 298653003523 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 298653003524 RAMP superfamily; Region: RAMPs; pfam03787 298653003525 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 298653003526 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 298653003527 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 298653003528 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 298653003529 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 298653003530 Transposase; Region: HTH_Tnp_1; pfam01527 298653003531 putative transposase OrfB; Reviewed; Region: PHA02517 298653003532 HTH-like domain; Region: HTH_21; pfam13276 298653003533 Integrase core domain; Region: rve; pfam00665 298653003534 Integrase core domain; Region: rve_3; pfam13683 298653003535 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 298653003536 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 298653003537 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693 298653003538 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 298653003539 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653003540 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653003541 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 298653003542 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 298653003543 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 298653003544 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 298653003545 active site 298653003546 DNA binding site [nucleotide binding] 298653003547 Int/Topo IB signature motif; other site 298653003548 Phosphotransferase enzyme family; Region: APH; pfam01636 298653003549 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 298653003550 active site 298653003551 ATP binding site [chemical binding]; other site 298653003552 substrate binding site [chemical binding]; other site 298653003553 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 298653003554 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653003555 Phosphotransferase enzyme family; Region: APH; pfam01636 298653003556 Methyltransferase domain; Region: Methyltransf_31; pfam13847 298653003557 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653003558 S-adenosylmethionine binding site [chemical binding]; other site 298653003559 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 298653003560 Winged helix-turn helix; Region: HTH_29; pfam13551 298653003561 HTH-like domain; Region: HTH_21; pfam13276 298653003562 Integrase core domain; Region: rve; pfam00665 298653003563 Integrase core domain; Region: rve_3; pfam13683 298653003564 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 298653003565 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653003566 NAD(P) binding site [chemical binding]; other site 298653003567 active site 298653003568 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653003569 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653003570 NAD(P) binding site [chemical binding]; other site 298653003571 active site 298653003572 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 298653003573 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 298653003574 active site 298653003575 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 298653003576 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 298653003577 [2Fe-2S] cluster binding site [ion binding]; other site 298653003578 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 298653003579 alpha subunit interface [polypeptide binding]; other site 298653003580 active site 298653003581 substrate binding site [chemical binding]; other site 298653003582 Fe binding site [ion binding]; other site 298653003583 Transcriptional regulators [Transcription]; Region: MarR; COG1846 298653003584 MarR family; Region: MarR_2; pfam12802 298653003585 Helix-turn-helix domains; Region: HTH; cl00088 298653003586 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 298653003587 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653003588 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 298653003589 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 298653003590 substrate binding pocket [chemical binding]; other site 298653003591 active site 298653003592 iron coordination sites [ion binding]; other site 298653003593 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 298653003594 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 298653003595 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 298653003596 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 298653003597 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 298653003598 active site 298653003599 substrate binding site [chemical binding]; other site 298653003600 ATP binding site [chemical binding]; other site 298653003601 Phosphotransferase enzyme family; Region: APH; pfam01636 298653003602 benzoylformate decarboxylase; Reviewed; Region: PRK07092 298653003603 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 298653003604 PYR/PP interface [polypeptide binding]; other site 298653003605 dimer interface [polypeptide binding]; other site 298653003606 TPP binding site [chemical binding]; other site 298653003607 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 298653003608 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 298653003609 TPP-binding site [chemical binding]; other site 298653003610 dimer interface [polypeptide binding]; other site 298653003611 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653003612 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653003613 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653003614 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 298653003615 active site 298653003616 Histidine kinase; Region: HisKA_3; pfam07730 298653003617 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653003618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653003619 active site 298653003620 phosphorylation site [posttranslational modification] 298653003621 intermolecular recognition site; other site 298653003622 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653003623 DNA binding residues [nucleotide binding] 298653003624 TOBE domain; Region: TOBE_2; cl01440 298653003625 TOBE domain; Region: TOBE_2; cl01440 298653003626 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 298653003627 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 298653003628 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 298653003629 camphor resistance protein CrcB; Provisional; Region: PRK14228 298653003630 CrcB-like protein; Region: CRCB; pfam02537 298653003631 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 298653003632 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653003633 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 298653003634 Helix-turn-helix domain; Region: HTH_17; pfam12728 298653003635 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653003636 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 298653003637 active site 298653003638 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 298653003639 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 298653003640 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 298653003641 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 298653003642 active site 298653003643 DNA binding site [nucleotide binding] 298653003644 Int/Topo IB signature motif; other site 298653003645 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 298653003646 DNA binding site [nucleotide binding] 298653003647 active site 298653003648 Int/Topo IB signature motif; other site 298653003649 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 298653003650 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 298653003651 S-adenosylmethionine binding site [chemical binding]; other site 298653003652 Transposase [DNA replication, recombination, and repair]; Region: COG5421 298653003653 ethanolamine utilization protein EutJ family protein; Region: EutJ; TIGR02529 298653003654 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 298653003655 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 298653003656 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 298653003657 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 298653003658 Integrase core domain; Region: rve; pfam00665 298653003659 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653003660 NmrA-like family; Region: NmrA; pfam05368 298653003661 NAD(P) binding site [chemical binding]; other site 298653003662 active site 298653003663 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653003664 Protein of unknown function DUF45; Region: DUF45; pfam01863 298653003665 Cupin; Region: Cupin_6; pfam12852 298653003666 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 298653003667 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 298653003668 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653003669 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653003670 short chain dehydrogenase; Provisional; Region: PRK06197 298653003671 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653003672 NAD(P) binding site [chemical binding]; other site 298653003673 active site 298653003674 AAA ATPase domain; Region: AAA_16; pfam13191 298653003675 Domain of unknown function DUF87; Region: DUF87; pfam01935 298653003676 AAA-like domain; Region: AAA_10; pfam12846 298653003677 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653003678 TIR domain; Region: TIR_2; pfam13676 298653003679 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 298653003680 putative active site [active] 298653003681 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 298653003682 Walker A motif; other site 298653003683 ATP binding site [chemical binding]; other site 298653003684 AAA domain; Region: AAA_11; pfam13086 298653003685 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 298653003686 AAA domain; Region: AAA_12; pfam13087 298653003687 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 298653003688 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 298653003689 [4Fe-4S] binding site [ion binding]; other site 298653003690 molybdopterin cofactor binding site; other site 298653003691 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 298653003692 molybdopterin cofactor binding site; other site 298653003693 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 298653003694 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 298653003695 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 298653003696 FAD binding pocket [chemical binding]; other site 298653003697 conserved FAD binding motif [chemical binding]; other site 298653003698 phosphate binding motif [ion binding]; other site 298653003699 beta-alpha-beta structure motif; other site 298653003700 NAD binding pocket [chemical binding]; other site 298653003701 nitrite reductase subunit NirD; Provisional; Region: PRK14989 298653003702 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 298653003703 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 298653003704 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 298653003705 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 298653003706 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 298653003707 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 298653003708 active site 298653003709 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 298653003710 DNA binding site [nucleotide binding] 298653003711 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 298653003712 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 298653003713 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 298653003714 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 298653003715 NAD(P) binding site [chemical binding]; other site 298653003716 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 298653003717 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 298653003718 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 298653003719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 298653003720 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 298653003721 Short C-terminal domain; Region: SHOCT; pfam09851 298653003722 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 298653003723 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653003724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653003725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653003726 Helix-turn-helix domain; Region: HTH_17; pfam12728 298653003727 DNA binding residues [nucleotide binding] 298653003728 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653003729 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653003730 Bacterial PH domain; Region: DUF304; pfam03703 298653003731 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 298653003732 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 298653003733 active site 298653003734 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 298653003735 catalytic triad [active] 298653003736 dimer interface [polypeptide binding]; other site 298653003737 RibD C-terminal domain; Region: RibD_C; pfam01872 298653003738 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 298653003739 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 298653003740 putative NADP binding site [chemical binding]; other site 298653003741 putative substrate binding site [chemical binding]; other site 298653003742 active site 298653003743 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 298653003744 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 298653003745 motif II; other site 298653003746 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 298653003747 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 298653003748 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 298653003749 catalytic residues [active] 298653003750 catalytic nucleophile [active] 298653003751 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 298653003752 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653003753 Helix-turn-helix domain; Region: HTH_17; pfam12728 298653003754 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653003755 S-adenosylmethionine binding site [chemical binding]; other site 298653003756 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 298653003757 active site 298653003758 NTP binding site [chemical binding]; other site 298653003759 metal binding triad [ion binding]; metal-binding site 298653003760 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 298653003761 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 298653003762 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 298653003763 Dimer interface [polypeptide binding]; other site 298653003764 anticodon binding site; other site 298653003765 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 298653003766 homodimer interface [polypeptide binding]; other site 298653003767 motif 1; other site 298653003768 motif 2; other site 298653003769 active site 298653003770 motif 3; other site 298653003771 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 298653003772 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653003773 non-specific DNA binding site [nucleotide binding]; other site 298653003774 salt bridge; other site 298653003775 sequence-specific DNA binding site [nucleotide binding]; other site 298653003776 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 298653003777 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 298653003778 metal binding site 2 [ion binding]; metal-binding site 298653003779 putative DNA binding helix; other site 298653003780 metal binding site 1 [ion binding]; metal-binding site 298653003781 dimer interface [polypeptide binding]; other site 298653003782 structural Zn2+ binding site [ion binding]; other site 298653003783 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 298653003784 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 298653003785 dimer interface [polypeptide binding]; other site 298653003786 active site 298653003787 heme binding site [chemical binding]; other site 298653003788 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 298653003789 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 298653003790 putative hydrophobic ligand binding site [chemical binding]; other site 298653003791 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 298653003792 dimerization interface [polypeptide binding]; other site 298653003793 putative DNA binding site [nucleotide binding]; other site 298653003794 putative Zn2+ binding site [ion binding]; other site 298653003795 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 298653003796 HicB family; Region: HicB; pfam05534 298653003797 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 298653003798 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653003799 putative substrate translocation pore; other site 298653003800 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653003801 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653003802 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 298653003803 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653003804 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 298653003805 Putative esterase; Region: Esterase; pfam00756 298653003806 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 298653003807 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 298653003808 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 298653003809 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 298653003810 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653003811 Family description; Region: UvrD_C_2; cl15862 298653003812 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 298653003813 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 298653003814 Probable transposase; Region: OrfB_IS605; pfam01385 298653003815 MoxR-like ATPases [General function prediction only]; Region: COG0714 298653003816 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 298653003817 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 298653003818 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 298653003819 Probable transposase; Region: OrfB_IS605; pfam01385 298653003820 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 298653003821 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 298653003822 metal ion-dependent adhesion site (MIDAS); other site 298653003823 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 298653003824 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 298653003825 active site 298653003826 catalytic tetrad [active] 298653003827 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 298653003828 Domain of unknown function (DUF385); Region: DUF385; pfam04075 298653003829 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 298653003830 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 298653003831 putative dimer interface [polypeptide binding]; other site 298653003832 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 298653003833 ligand binding site [chemical binding]; other site 298653003834 Zn binding site [ion binding]; other site 298653003835 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 298653003836 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 298653003837 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 298653003838 catalytic residue [active] 298653003839 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653003840 Amidohydrolase; Region: Amidohydro_2; pfam04909 298653003841 Transcriptional regulators [Transcription]; Region: GntR; COG1802 298653003842 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 298653003843 DNA-binding site [nucleotide binding]; DNA binding site 298653003844 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 298653003845 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 298653003846 putative dimer interface [polypeptide binding]; other site 298653003847 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 298653003848 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 298653003849 nucleotide binding site [chemical binding]; other site 298653003850 NEF interaction site [polypeptide binding]; other site 298653003851 SBD interface [polypeptide binding]; other site 298653003852 GrpE; Region: GrpE; pfam01025 298653003853 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 298653003854 dimer interface [polypeptide binding]; other site 298653003855 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 298653003856 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 298653003857 HSP70 interaction site [polypeptide binding]; other site 298653003858 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 298653003859 substrate binding site [polypeptide binding]; other site 298653003860 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 298653003861 dimer interface [polypeptide binding]; other site 298653003862 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 298653003863 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 298653003864 NAD binding site [chemical binding]; other site 298653003865 catalytic Zn binding site [ion binding]; other site 298653003866 structural Zn binding site [ion binding]; other site 298653003867 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653003868 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653003869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653003870 MMPL family; Region: MMPL; pfam03176 298653003871 Transport protein; Region: actII; TIGR00833 298653003872 Transcriptional regulators [Transcription]; Region: MarR; COG1846 298653003873 MarR family; Region: MarR; pfam01047 298653003874 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 298653003875 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 298653003876 nudix motif; other site 298653003877 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 298653003878 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 298653003879 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 298653003880 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 298653003881 classical (c) SDRs; Region: SDR_c; cd05233 298653003882 NAD(P) binding site [chemical binding]; other site 298653003883 active site 298653003884 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 298653003885 DNA binding site [nucleotide binding] 298653003886 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 298653003887 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 298653003888 Predicted ATPase [General function prediction only]; Region: COG3903 298653003889 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 298653003890 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 298653003891 putative NAD(P) binding site [chemical binding]; other site 298653003892 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 298653003893 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653003894 non-specific DNA binding site [nucleotide binding]; other site 298653003895 salt bridge; other site 298653003896 sequence-specific DNA binding site [nucleotide binding]; other site 298653003897 Domain of unknown function (DUF955); Region: DUF955; pfam06114 298653003898 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 298653003899 dimerization interface [polypeptide binding]; other site 298653003900 putative DNA binding site [nucleotide binding]; other site 298653003901 putative Zn2+ binding site [ion binding]; other site 298653003902 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 298653003903 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653003904 Phosphotransferase enzyme family; Region: APH; pfam01636 298653003905 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 298653003906 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 298653003907 Transposase [DNA replication, recombination, and repair]; Region: COG5421 298653003908 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 298653003909 CoenzymeA binding site [chemical binding]; other site 298653003910 subunit interaction site [polypeptide binding]; other site 298653003911 PHB binding site; other site 298653003912 prephenate dehydratase; Provisional; Region: PRK11898 298653003913 Prephenate dehydratase; Region: PDT; pfam00800 298653003914 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 298653003915 putative L-Phe binding site [chemical binding]; other site 298653003916 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 298653003917 E3 interaction surface; other site 298653003918 lipoyl attachment site [posttranslational modification]; other site 298653003919 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 298653003920 e3 binding domain; Region: E3_binding; pfam02817 298653003921 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 298653003922 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 298653003923 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 298653003924 alpha subunit interface [polypeptide binding]; other site 298653003925 TPP binding site [chemical binding]; other site 298653003926 heterodimer interface [polypeptide binding]; other site 298653003927 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 298653003928 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 298653003929 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 298653003930 tetramer interface [polypeptide binding]; other site 298653003931 TPP-binding site [chemical binding]; other site 298653003932 heterodimer interface [polypeptide binding]; other site 298653003933 phosphorylation loop region [posttranslational modification] 298653003934 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 298653003935 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653003936 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653003937 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 298653003938 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 298653003939 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 298653003940 DNA binding residues [nucleotide binding] 298653003941 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653003942 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653003943 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653003944 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653003945 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 298653003946 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 298653003947 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 298653003948 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 298653003949 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653003950 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653003951 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653003952 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653003953 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653003954 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653003955 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653003956 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 298653003957 active site 298653003958 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653003959 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653003960 NAD(P) binding site [chemical binding]; other site 298653003961 active site 298653003962 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 298653003963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 298653003964 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 298653003965 DNA-binding response regulator CreB; Provisional; Region: PRK11083 298653003966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653003967 active site 298653003968 phosphorylation site [posttranslational modification] 298653003969 intermolecular recognition site; other site 298653003970 dimerization interface [polypeptide binding]; other site 298653003971 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 298653003972 DNA binding site [nucleotide binding] 298653003973 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 298653003974 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 298653003975 dimer interface [polypeptide binding]; other site 298653003976 phosphorylation site [posttranslational modification] 298653003977 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 298653003978 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 298653003979 catalytic residues [active] 298653003980 catalytic nucleophile [active] 298653003981 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 298653003982 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 298653003983 Probable transposase; Region: OrfB_IS605; pfam01385 298653003984 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 298653003985 SnoaL-like domain; Region: SnoaL_2; pfam12680 298653003986 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 298653003987 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 298653003988 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 298653003989 putative dimerization interface [polypeptide binding]; other site 298653003990 hypothetical protein; Provisional; Region: PRK08317 298653003991 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653003992 S-adenosylmethionine binding site [chemical binding]; other site 298653003993 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653003994 enoyl-CoA hydratase; Provisional; Region: PRK08290 298653003995 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653003996 substrate binding site [chemical binding]; other site 298653003997 oxyanion hole (OAH) forming residues; other site 298653003998 trimer interface [polypeptide binding]; other site 298653003999 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 298653004000 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653004001 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 298653004002 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 298653004003 active site 298653004004 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653004005 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653004006 active site 298653004007 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 298653004008 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 298653004009 NADH(P)-binding; Region: NAD_binding_10; pfam13460 298653004010 NAD binding site [chemical binding]; other site 298653004011 substrate binding site [chemical binding]; other site 298653004012 putative active site [active] 298653004013 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 298653004014 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 298653004015 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 298653004016 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 298653004017 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 298653004018 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 298653004019 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 298653004020 Uncharacterized conserved protein [Function unknown]; Region: COG2128 298653004021 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 298653004022 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 298653004023 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 298653004024 active site 298653004025 iron coordination sites [ion binding]; other site 298653004026 substrate binding pocket [chemical binding]; other site 298653004027 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 298653004028 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 298653004029 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 298653004030 putative triphosphate binding site [ion binding]; other site 298653004031 signature motif; other site 298653004032 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653004033 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653004034 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 298653004035 hypothetical protein; Provisional; Region: PRK07208 298653004036 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 298653004037 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 298653004038 dinuclear metal binding motif [ion binding]; other site 298653004039 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 298653004040 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 298653004041 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 298653004042 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 298653004043 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 298653004044 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 298653004045 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 298653004046 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 298653004047 substrate binding pocket [chemical binding]; other site 298653004048 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 298653004049 B12 binding site [chemical binding]; other site 298653004050 cobalt ligand [ion binding]; other site 298653004051 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 298653004052 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 298653004053 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 298653004054 N-acetyl-D-glucosamine binding site [chemical binding]; other site 298653004055 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 298653004056 active site 298653004057 HTH domain; Region: HTH_11; pfam08279 298653004058 WYL domain; Region: WYL; pfam13280 298653004059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 298653004060 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 298653004061 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653004062 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653004063 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 298653004064 MarR family; Region: MarR; pfam01047 298653004065 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 298653004066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653004067 putative substrate translocation pore; other site 298653004068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653004069 putative substrate translocation pore; other site 298653004070 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653004071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653004072 active site 298653004073 phosphorylation site [posttranslational modification] 298653004074 intermolecular recognition site; other site 298653004075 dimerization interface [polypeptide binding]; other site 298653004076 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653004077 DNA binding residues [nucleotide binding] 298653004078 dimerization interface [polypeptide binding]; other site 298653004079 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 298653004080 Histidine kinase; Region: HisKA_3; pfam07730 298653004081 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 298653004082 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 298653004083 Walker A/P-loop; other site 298653004084 ATP binding site [chemical binding]; other site 298653004085 Q-loop/lid; other site 298653004086 ABC transporter signature motif; other site 298653004087 Walker B; other site 298653004088 D-loop; other site 298653004089 H-loop/switch region; other site 298653004090 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 298653004091 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 298653004092 active site 298653004093 trimer interface [polypeptide binding]; other site 298653004094 dimer interface [polypeptide binding]; other site 298653004095 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 298653004096 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 298653004097 inhibitor-cofactor binding pocket; inhibition site 298653004098 pyridoxal 5'-phosphate binding site [chemical binding]; other site 298653004099 catalytic residue [active] 298653004100 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 298653004101 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 298653004102 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 298653004103 3-amino-5-hydroxybenoic acid synthesis related protein; Region: AHBA_synth_RP; TIGR01454 298653004104 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 298653004105 motif II; other site 298653004106 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 298653004107 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 298653004108 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 298653004109 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 298653004110 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 298653004111 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 298653004112 NAD(P) binding site [chemical binding]; other site 298653004113 shikimate binding site; other site 298653004114 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 298653004115 active site 298653004116 dimer interface [polypeptide binding]; other site 298653004117 metal binding site [ion binding]; metal-binding site 298653004118 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 298653004119 AMP-binding enzyme; Region: AMP-binding; cl15778 298653004120 AMP-binding enzyme; Region: AMP-binding; cl15778 298653004121 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 298653004122 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 298653004123 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 298653004124 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 298653004125 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653004126 Q-loop/lid; other site 298653004127 ABC transporter signature motif; other site 298653004128 Walker B; other site 298653004129 D-loop; other site 298653004130 H-loop/switch region; other site 298653004131 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 298653004132 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653004133 non-specific DNA binding site [nucleotide binding]; other site 298653004134 salt bridge; other site 298653004135 sequence-specific DNA binding site [nucleotide binding]; other site 298653004136 Cupin domain; Region: Cupin_2; pfam07883 298653004137 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 298653004138 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 298653004139 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 298653004140 pyridoxal 5'-phosphate binding site [chemical binding]; other site 298653004141 homodimer interface [polypeptide binding]; other site 298653004142 catalytic residue [active] 298653004143 Domain of unknown function (DUF222); Region: DUF222; pfam02720 298653004144 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 298653004145 active site 298653004146 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653004147 S-adenosylmethionine binding site [chemical binding]; other site 298653004148 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 298653004149 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 298653004150 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 298653004151 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 298653004152 NAD binding site [chemical binding]; other site 298653004153 putative substrate binding site 2 [chemical binding]; other site 298653004154 putative substrate binding site 1 [chemical binding]; other site 298653004155 active site 298653004156 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 298653004157 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653004158 Transcriptional regulators [Transcription]; Region: FadR; COG2186 298653004159 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 298653004160 DNA-binding site [nucleotide binding]; DNA binding site 298653004161 FCD domain; Region: FCD; pfam07729 298653004162 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 298653004163 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 298653004164 ligand binding site [chemical binding]; other site 298653004165 flexible hinge region; other site 298653004166 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 298653004167 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 298653004168 metal-binding site [ion binding] 298653004169 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 298653004170 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 298653004171 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 298653004172 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 298653004173 MMPL family; Region: MMPL; pfam03176 298653004174 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653004175 Transcriptional regulators [Transcription]; Region: PurR; COG1609 298653004176 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 298653004177 DNA binding site [nucleotide binding] 298653004178 domain linker motif; other site 298653004179 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 298653004180 ligand binding site [chemical binding]; other site 298653004181 dimerization interface [polypeptide binding]; other site 298653004182 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 298653004183 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 298653004184 active site 298653004185 HIGH motif; other site 298653004186 nucleotide binding site [chemical binding]; other site 298653004187 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 298653004188 active site 298653004189 KMSKS motif; other site 298653004190 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 298653004191 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 298653004192 Transcriptional regulators [Transcription]; Region: FadR; COG2186 298653004193 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 298653004194 DNA-binding site [nucleotide binding]; DNA binding site 298653004195 Transcriptional regulators [Transcription]; Region: FadR; COG2186 298653004196 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 298653004197 DNA-binding site [nucleotide binding]; DNA binding site 298653004198 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 298653004199 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 298653004200 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 298653004201 recombination factor protein RarA; Reviewed; Region: PRK13342 298653004202 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 298653004203 Walker A motif; other site 298653004204 ATP binding site [chemical binding]; other site 298653004205 Walker B motif; other site 298653004206 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 298653004207 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 298653004208 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 298653004209 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 298653004210 motif 1; other site 298653004211 active site 298653004212 motif 2; other site 298653004213 motif 3; other site 298653004214 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 298653004215 DHHA1 domain; Region: DHHA1; pfam02272 298653004216 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 298653004217 YceG-like family; Region: YceG; pfam02618 298653004218 proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675 298653004219 dimerization interface [polypeptide binding]; other site 298653004220 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 298653004221 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 298653004222 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 298653004223 NAD(P) binding site [chemical binding]; other site 298653004224 shikimate binding site; other site 298653004225 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 298653004226 Tetramer interface [polypeptide binding]; other site 298653004227 active site 298653004228 FMN-binding site [chemical binding]; other site 298653004229 shikimate kinase; Reviewed; Region: aroK; PRK00131 298653004230 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 298653004231 ADP binding site [chemical binding]; other site 298653004232 magnesium binding site [ion binding]; other site 298653004233 putative shikimate binding site; other site 298653004234 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 298653004235 active site 298653004236 dimer interface [polypeptide binding]; other site 298653004237 metal binding site [ion binding]; metal-binding site 298653004238 elongation factor P; Validated; Region: PRK00529 298653004239 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 298653004240 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 298653004241 RNA binding site [nucleotide binding]; other site 298653004242 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 298653004243 RNA binding site [nucleotide binding]; other site 298653004244 transcription antitermination factor NusB; Region: nusB; TIGR01951 298653004245 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 298653004246 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653004247 non-specific DNA binding site [nucleotide binding]; other site 298653004248 salt bridge; other site 298653004249 sequence-specific DNA binding site [nucleotide binding]; other site 298653004250 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 298653004251 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 298653004252 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 298653004253 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 298653004254 dihydroorotase; Validated; Region: pyrC; PRK09357 298653004255 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 298653004256 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 298653004257 active site 298653004258 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 298653004259 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 298653004260 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 298653004261 catalytic site [active] 298653004262 subunit interface [polypeptide binding]; other site 298653004263 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 298653004264 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 298653004265 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 298653004266 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 298653004267 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 298653004268 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 298653004269 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 298653004270 IMP binding site; other site 298653004271 dimer interface [polypeptide binding]; other site 298653004272 interdomain contacts; other site 298653004273 partial ornithine binding site; other site 298653004274 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 298653004275 active site 298653004276 dimer interface [polypeptide binding]; other site 298653004277 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 298653004278 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 298653004279 Guanylate kinase; Region: Guanylate_kin; pfam00625 298653004280 catalytic site [active] 298653004281 G-X2-G-X-G-K; other site 298653004282 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 298653004283 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 298653004284 Flavoprotein; Region: Flavoprotein; pfam02441 298653004285 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 298653004286 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 298653004287 S-adenosylmethionine synthetase; Validated; Region: PRK05250 298653004288 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 298653004289 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 298653004290 primosome assembly protein PriA; Provisional; Region: PRK14873 298653004291 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 298653004292 active site 298653004293 catalytic residues [active] 298653004294 metal binding site [ion binding]; metal-binding site 298653004295 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 298653004296 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 298653004297 putative active site [active] 298653004298 substrate binding site [chemical binding]; other site 298653004299 putative cosubstrate binding site; other site 298653004300 catalytic site [active] 298653004301 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 298653004302 substrate binding site [chemical binding]; other site 298653004303 NusB family; Region: NusB; pfam01029 298653004304 putative RNA binding site [nucleotide binding]; other site 298653004305 16S rRNA methyltransferase B; Provisional; Region: PRK14902 298653004306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 298653004307 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 298653004308 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 298653004309 substrate binding site [chemical binding]; other site 298653004310 hexamer interface [polypeptide binding]; other site 298653004311 metal binding site [ion binding]; metal-binding site 298653004312 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 298653004313 catalytic motif [active] 298653004314 Zn binding site [ion binding]; other site 298653004315 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 298653004316 Lumazine binding domain; Region: Lum_binding; pfam00677 298653004317 Lumazine binding domain; Region: Lum_binding; pfam00677 298653004318 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 298653004319 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 298653004320 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 298653004321 dimerization interface [polypeptide binding]; other site 298653004322 active site 298653004323 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 298653004324 homopentamer interface [polypeptide binding]; other site 298653004325 active site 298653004326 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 298653004327 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 298653004328 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 298653004329 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 298653004330 ribosomal protein L20; Region: rpl20; CHL00068 298653004331 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 298653004332 23S rRNA binding site [nucleotide binding]; other site 298653004333 L21 binding site [polypeptide binding]; other site 298653004334 L13 binding site [polypeptide binding]; other site 298653004335 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 298653004336 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 298653004337 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 298653004338 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 298653004339 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 298653004340 dimer interface [polypeptide binding]; other site 298653004341 phosphorylation site [posttranslational modification] 298653004342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653004343 ATP binding site [chemical binding]; other site 298653004344 Mg2+ binding site [ion binding]; other site 298653004345 G-X-G motif; other site 298653004346 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 298653004347 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 298653004348 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 298653004349 dimer interface [polypeptide binding]; other site 298653004350 motif 1; other site 298653004351 active site 298653004352 motif 2; other site 298653004353 motif 3; other site 298653004354 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 298653004355 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 298653004356 putative tRNA-binding site [nucleotide binding]; other site 298653004357 B3/4 domain; Region: B3_4; pfam03483 298653004358 tRNA synthetase B5 domain; Region: B5; smart00874 298653004359 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 298653004360 dimer interface [polypeptide binding]; other site 298653004361 motif 1; other site 298653004362 motif 3; other site 298653004363 motif 2; other site 298653004364 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 298653004365 hypothetical protein; Provisional; Region: PRK05409 298653004366 TIGR04222 domain; Region: near_uncomplex 298653004367 TIGR04222 domain; Region: near_uncomplex 298653004368 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 298653004369 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 298653004370 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 298653004371 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 298653004372 heterotetramer interface [polypeptide binding]; other site 298653004373 active site pocket [active] 298653004374 cleavage site 298653004375 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 298653004376 feedback inhibition sensing region; other site 298653004377 homohexameric interface [polypeptide binding]; other site 298653004378 nucleotide binding site [chemical binding]; other site 298653004379 N-acetyl-L-glutamate binding site [chemical binding]; other site 298653004380 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 298653004381 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 298653004382 inhibitor-cofactor binding pocket; inhibition site 298653004383 pyridoxal 5'-phosphate binding site [chemical binding]; other site 298653004384 catalytic residue [active] 298653004385 ornithine carbamoyltransferase; Provisional; Region: PRK00779 298653004386 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 298653004387 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 298653004388 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 298653004389 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 298653004390 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 298653004391 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 298653004392 ANP binding site [chemical binding]; other site 298653004393 Substrate Binding Site II [chemical binding]; other site 298653004394 Substrate Binding Site I [chemical binding]; other site 298653004395 argininosuccinate lyase; Provisional; Region: PRK00855 298653004396 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 298653004397 active sites [active] 298653004398 tetramer interface [polypeptide binding]; other site 298653004399 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 298653004400 active site 298653004401 DNA binding site [nucleotide binding] 298653004402 tetratricopeptide repeat protein; Provisional; Region: PRK11788 298653004403 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 298653004404 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 298653004405 binding surface 298653004406 TPR motif; other site 298653004407 Tetratricopeptide repeat; Region: TPR_16; pfam13432 298653004408 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 298653004409 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 298653004410 active site 298653004411 motif I; other site 298653004412 motif II; other site 298653004413 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 298653004414 SCP-2 sterol transfer family; Region: SCP2; pfam02036 298653004415 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 298653004416 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 298653004417 RNA binding surface [nucleotide binding]; other site 298653004418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653004419 S-adenosylmethionine binding site [chemical binding]; other site 298653004420 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 298653004421 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 298653004422 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 298653004423 Walker A/P-loop; other site 298653004424 ATP binding site [chemical binding]; other site 298653004425 Q-loop/lid; other site 298653004426 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 298653004427 ABC transporter signature motif; other site 298653004428 Walker B; other site 298653004429 D-loop; other site 298653004430 H-loop/switch region; other site 298653004431 CTP synthetase; Validated; Region: pyrG; PRK05380 298653004432 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 298653004433 Catalytic site [active] 298653004434 active site 298653004435 UTP binding site [chemical binding]; other site 298653004436 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 298653004437 active site 298653004438 putative oxyanion hole; other site 298653004439 catalytic triad [active] 298653004440 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 298653004441 dimer interface [polypeptide binding]; other site 298653004442 active site 298653004443 ADP-ribose binding site [chemical binding]; other site 298653004444 nudix motif; other site 298653004445 metal binding site [ion binding]; metal-binding site 298653004446 PKD domain; Region: PKD; pfam00801 298653004447 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 298653004448 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 298653004449 active site 298653004450 DNA binding site [nucleotide binding] 298653004451 Int/Topo IB signature motif; other site 298653004452 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653004453 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 298653004454 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 298653004455 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 298653004456 intersubunit interface [polypeptide binding]; other site 298653004457 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 298653004458 oligomerization interface [polypeptide binding]; other site 298653004459 active site 298653004460 metal binding site [ion binding]; metal-binding site 298653004461 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653004462 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653004463 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 298653004464 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 298653004465 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 298653004466 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 298653004467 active site 298653004468 dimer interface [polypeptide binding]; other site 298653004469 motif 1; other site 298653004470 motif 2; other site 298653004471 motif 3; other site 298653004472 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 298653004473 anticodon binding site; other site 298653004474 NAD synthetase; Provisional; Region: PRK13981 298653004475 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 298653004476 multimer interface [polypeptide binding]; other site 298653004477 active site 298653004478 catalytic triad [active] 298653004479 protein interface 1 [polypeptide binding]; other site 298653004480 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 298653004481 homodimer interface [polypeptide binding]; other site 298653004482 NAD binding pocket [chemical binding]; other site 298653004483 ATP binding pocket [chemical binding]; other site 298653004484 Mg binding site [ion binding]; other site 298653004485 active-site loop [active] 298653004486 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 298653004487 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 298653004488 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 298653004489 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 298653004490 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 298653004491 metal binding triad; other site 298653004492 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 298653004493 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 298653004494 metal binding triad; other site 298653004495 Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_1; cd09104 298653004496 putative active site [active] 298653004497 catalytic site [active] 298653004498 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 298653004499 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 298653004500 PLD-like domain; Region: PLDc_2; pfam13091 298653004501 putative active site [active] 298653004502 catalytic site [active] 298653004503 glutamine synthetase; Region: PLN02284 298653004504 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 298653004505 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 298653004506 glutamine synthetase, type I; Region: GlnA; TIGR00653 298653004507 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 298653004508 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 298653004509 RDD family; Region: RDD; pfam06271 298653004510 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 298653004511 lipoyl synthase; Provisional; Region: PRK05481 298653004512 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 298653004513 FeS/SAM binding site; other site 298653004514 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 298653004515 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 298653004516 active site pocket [active] 298653004517 oxyanion hole [active] 298653004518 catalytic triad [active] 298653004519 active site nucleophile [active] 298653004520 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 298653004521 active site 298653004522 ATP binding site [chemical binding]; other site 298653004523 substrate binding site [chemical binding]; other site 298653004524 activation loop (A-loop); other site 298653004525 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653004526 TIGR01777 family protein; Region: yfcH 298653004527 NAD(P) binding site [chemical binding]; other site 298653004528 active site 298653004529 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 298653004530 E3 interaction surface; other site 298653004531 lipoyl attachment site [posttranslational modification]; other site 298653004532 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 298653004533 e3 binding domain; Region: E3_binding; pfam02817 298653004534 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 298653004535 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 298653004536 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 298653004537 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 298653004538 multifunctional aminopeptidase A; Provisional; Region: PRK00913 298653004539 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 298653004540 interface (dimer of trimers) [polypeptide binding]; other site 298653004541 Substrate-binding/catalytic site; other site 298653004542 Zn-binding sites [ion binding]; other site 298653004543 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 298653004544 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 298653004545 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 298653004546 cobalamin synthase; Reviewed; Region: cobS; PRK00235 298653004547 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 298653004548 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 298653004549 Probable transposase; Region: OrfB_IS605; pfam01385 298653004550 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 298653004551 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 298653004552 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 298653004553 putative dimer interface [polypeptide binding]; other site 298653004554 active site pocket [active] 298653004555 putative cataytic base [active] 298653004556 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 298653004557 NB-ARC domain; Region: NB-ARC; pfam00931 298653004558 FOG: WD40 repeat [General function prediction only]; Region: COG2319 298653004559 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 298653004560 structural tetrad; other site 298653004561 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 298653004562 FOG: WD40 repeat [General function prediction only]; Region: COG2319 298653004563 structural tetrad; other site 298653004564 WD40 repeats; Region: WD40; smart00320 298653004565 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 298653004566 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 298653004567 NAD binding site [chemical binding]; other site 298653004568 catalytic residues [active] 298653004569 Autophagocytosis associated protein (Atg3), N-terminal domain; Region: Autophagy_N; pfam03986 298653004570 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653004571 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 298653004572 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 298653004573 homotrimer interface [polypeptide binding]; other site 298653004574 Walker A motif; other site 298653004575 GTP binding site [chemical binding]; other site 298653004576 Walker B motif; other site 298653004577 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653004578 WHG domain; Region: WHG; pfam13305 298653004579 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 298653004580 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 298653004581 active site 298653004582 catalytic tetrad [active] 298653004583 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 298653004584 quinolinate synthetase; Provisional; Region: PRK09375 298653004585 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 298653004586 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 298653004587 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 298653004588 substrate binding site [chemical binding]; other site 298653004589 ATP binding site [chemical binding]; other site 298653004590 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 298653004591 CPxP motif; other site 298653004592 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 298653004593 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 298653004594 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 298653004595 catalytic residue [active] 298653004596 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 298653004597 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 298653004598 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 298653004599 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 298653004600 D-pathway; other site 298653004601 Putative ubiquinol binding site [chemical binding]; other site 298653004602 Low-spin heme (heme b) binding site [chemical binding]; other site 298653004603 Putative water exit pathway; other site 298653004604 Binuclear center (heme o3/CuB) [ion binding]; other site 298653004605 K-pathway; other site 298653004606 Putative proton exit pathway; other site 298653004607 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 298653004608 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 298653004609 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 298653004610 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 298653004611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 298653004612 active site 298653004613 phosphorylation site [posttranslational modification] 298653004614 intermolecular recognition site; other site 298653004615 dimerization interface [polypeptide binding]; other site 298653004616 ferric uptake regulator; Provisional; Region: fur; PRK09462 298653004617 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 298653004618 metal binding site 2 [ion binding]; metal-binding site 298653004619 putative DNA binding helix; other site 298653004620 metal binding site 1 [ion binding]; metal-binding site 298653004621 dimer interface [polypeptide binding]; other site 298653004622 structural Zn2+ binding site [ion binding]; other site 298653004623 Rubrerythrin [Energy production and conversion]; Region: COG1592 298653004624 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 298653004625 binuclear metal center [ion binding]; other site 298653004626 Protein of unknown function (DUF3501); Region: DUF3501; pfam12007 298653004627 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 298653004628 Subunit I/III interface [polypeptide binding]; other site 298653004629 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 298653004630 Cytochrome c; Region: Cytochrom_C; pfam00034 298653004631 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 298653004632 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 298653004633 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 298653004634 iron-sulfur cluster [ion binding]; other site 298653004635 [2Fe-2S] cluster binding site [ion binding]; other site 298653004636 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 298653004637 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 298653004638 heme bH binding site [chemical binding]; other site 298653004639 intrachain domain interface; other site 298653004640 heme bL binding site [chemical binding]; other site 298653004641 interchain domain interface [polypeptide binding]; other site 298653004642 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 298653004643 Qo binding site; other site 298653004644 hypothetical protein; Validated; Region: PRK07883 298653004645 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 298653004646 active site 298653004647 catalytic site [active] 298653004648 substrate binding site [chemical binding]; other site 298653004649 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 298653004650 GIY-YIG motif/motif A; other site 298653004651 active site 298653004652 catalytic site [active] 298653004653 putative DNA binding site [nucleotide binding]; other site 298653004654 metal binding site [ion binding]; metal-binding site 298653004655 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 298653004656 active site 298653004657 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 298653004658 nucleotide binding site/active site [active] 298653004659 HIT family signature motif; other site 298653004660 catalytic residue [active] 298653004661 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 298653004662 YacP-like NYN domain; Region: NYN_YacP; cl01491 298653004663 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 298653004664 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 298653004665 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 298653004666 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653004667 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 298653004668 active site 298653004669 metal binding site [ion binding]; metal-binding site 298653004670 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 298653004671 putative hydrophobic ligand binding site [chemical binding]; other site 298653004672 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 298653004673 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 298653004674 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 298653004675 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 298653004676 nucleotide binding site [chemical binding]; other site 298653004677 TIGR00300 family protein; Region: TIGR00300 298653004678 LOR/SDH bifunctional enzyme conserved region; Region: Saccharop_dh_N; pfam04455 298653004679 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653004680 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 298653004681 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 298653004682 putative acyl-acceptor binding pocket; other site 298653004683 AMP deaminase; Provisional; Region: PTZ00310 298653004684 phosphofructokinase; Region: PFK_mixed; TIGR02483 298653004685 active site 298653004686 ADP/pyrophosphate binding site [chemical binding]; other site 298653004687 dimerization interface [polypeptide binding]; other site 298653004688 allosteric effector site; other site 298653004689 fructose-1,6-bisphosphate binding site; other site 298653004690 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 298653004691 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653004692 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653004693 active site 298653004694 ATP binding site [chemical binding]; other site 298653004695 substrate binding site [chemical binding]; other site 298653004696 activation loop (A-loop); other site 298653004697 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 298653004698 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 298653004699 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 298653004700 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 298653004701 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 298653004702 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 298653004703 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 298653004704 ThiS interaction site; other site 298653004705 putative active site [active] 298653004706 tetramer interface [polypeptide binding]; other site 298653004707 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 298653004708 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 298653004709 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 298653004710 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 298653004711 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 298653004712 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 298653004713 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 298653004714 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 298653004715 thiS-thiF/thiG interaction site; other site 298653004716 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 298653004717 thiamine phosphate binding site [chemical binding]; other site 298653004718 active site 298653004719 pyrophosphate binding site [ion binding]; other site 298653004720 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 298653004721 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 298653004722 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 298653004723 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 298653004724 putative metal binding site [ion binding]; other site 298653004725 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 298653004726 Probable transposase; Region: OrfB_IS605; pfam01385 298653004727 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 298653004728 Transposase IS200 like; Region: Y1_Tnp; pfam01797 298653004729 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 298653004730 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 298653004731 motif II; other site 298653004732 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653004733 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 298653004734 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 298653004735 Ligand binding site; other site 298653004736 Putative Catalytic site; other site 298653004737 DXD motif; other site 298653004738 putative lipid kinase; Reviewed; Region: PRK13057 298653004739 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 298653004740 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 298653004741 dimer interface [polypeptide binding]; other site 298653004742 TPP-binding site [chemical binding]; other site 298653004743 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 298653004744 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 298653004745 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 298653004746 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 298653004747 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 298653004748 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 298653004749 dimer interface [polypeptide binding]; other site 298653004750 catalytic triad [active] 298653004751 PemK-like protein; Region: PemK; cl00995 298653004752 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 298653004753 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 298653004754 putative active site [active] 298653004755 catalytic triad [active] 298653004756 putative dimer interface [polypeptide binding]; other site 298653004757 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653004758 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653004759 active site 298653004760 ATP binding site [chemical binding]; other site 298653004761 substrate binding site [chemical binding]; other site 298653004762 activation loop (A-loop); other site 298653004763 FOG: WD40 repeat [General function prediction only]; Region: COG2319 298653004764 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 298653004765 structural tetrad; other site 298653004766 Predicted transcriptional regulator [Transcription]; Region: COG2378 298653004767 HTH domain; Region: HTH_11; pfam08279 298653004768 WYL domain; Region: WYL; pfam13280 298653004769 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 298653004770 active site 298653004771 metal binding site [ion binding]; metal-binding site 298653004772 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 298653004773 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653004774 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 298653004775 TIR domain; Region: TIR_2; pfam13676 298653004776 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 298653004777 NMT1-like family; Region: NMT1_2; cl15260 298653004778 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 298653004779 motif II; other site 298653004780 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 298653004781 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653004782 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653004783 FAD dependent oxidoreductase; Region: DAO; pfam01266 298653004784 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 298653004785 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 298653004786 Transcriptional regulators [Transcription]; Region: PurR; COG1609 298653004787 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 298653004788 DNA binding site [nucleotide binding] 298653004789 domain linker motif; other site 298653004790 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 298653004791 dimerization interface [polypeptide binding]; other site 298653004792 ligand binding site [chemical binding]; other site 298653004793 Predicted transcriptional regulators [Transcription]; Region: COG1733 298653004794 NAD(P) binding site [chemical binding]; other site 298653004795 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653004796 NADH(P)-binding; Region: NAD_binding_10; pfam13460 298653004797 active site 298653004798 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 298653004799 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 298653004800 trimer interface [polypeptide binding]; other site 298653004801 active site 298653004802 substrate binding site [chemical binding]; other site 298653004803 CoA binding site [chemical binding]; other site 298653004804 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 298653004805 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653004806 NAD(P) binding site [chemical binding]; other site 298653004807 active site 298653004808 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 298653004809 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 298653004810 putative active site [active] 298653004811 putative substrate binding site [chemical binding]; other site 298653004812 ATP binding site [chemical binding]; other site 298653004813 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653004814 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 298653004815 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 298653004816 active site 298653004817 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653004818 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653004819 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533 298653004820 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231; cd11544 298653004821 homodimer interface [polypeptide binding]; other site 298653004822 active site 298653004823 metal binding site [ion binding]; metal-binding site 298653004824 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 298653004825 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 298653004826 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 298653004827 Probable transposase; Region: OrfB_IS605; pfam01385 298653004828 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 298653004829 nucleophile elbow; other site 298653004830 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 298653004831 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 298653004832 CoenzymeA binding site [chemical binding]; other site 298653004833 subunit interaction site [polypeptide binding]; other site 298653004834 PHB binding site; other site 298653004835 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 298653004836 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 298653004837 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 298653004838 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 298653004839 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 298653004840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653004841 dimer interface [polypeptide binding]; other site 298653004842 conserved gate region; other site 298653004843 putative PBP binding loops; other site 298653004844 ABC-ATPase subunit interface; other site 298653004845 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 298653004846 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653004847 Walker A/P-loop; other site 298653004848 ATP binding site [chemical binding]; other site 298653004849 Q-loop/lid; other site 298653004850 ABC transporter signature motif; other site 298653004851 Walker B; other site 298653004852 D-loop; other site 298653004853 H-loop/switch region; other site 298653004854 TOBE domain; Region: TOBE_2; pfam08402 298653004855 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653004856 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653004857 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653004858 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 298653004859 CoenzymeA binding site [chemical binding]; other site 298653004860 subunit interaction site [polypeptide binding]; other site 298653004861 PHB binding site; other site 298653004862 acyl-CoA synthetase; Validated; Region: PRK05850 298653004863 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653004864 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653004865 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 298653004866 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653004867 S-adenosylmethionine binding site [chemical binding]; other site 298653004868 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 298653004869 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 298653004870 Fatty acid desaturase; Region: FA_desaturase; pfam00487 298653004871 putative di-iron ligands [ion binding]; other site 298653004872 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 298653004873 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 298653004874 nudix motif; other site 298653004875 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653004876 short chain dehydrogenase; Validated; Region: PRK07069 298653004877 NAD(P) binding site [chemical binding]; other site 298653004878 active site 298653004879 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 298653004880 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653004881 S-adenosylmethionine binding site [chemical binding]; other site 298653004882 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 298653004883 O-methyltransferase; Region: Methyltransf_3; pfam01596 298653004884 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653004885 S-adenosylmethionine binding site [chemical binding]; other site 298653004886 histidinol dehydrogenase; Region: hisD; TIGR00069 298653004887 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 298653004888 NAD binding site [chemical binding]; other site 298653004889 dimerization interface [polypeptide binding]; other site 298653004890 product binding site; other site 298653004891 substrate binding site [chemical binding]; other site 298653004892 zinc binding site [ion binding]; other site 298653004893 catalytic residues [active] 298653004894 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 298653004895 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 298653004896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 298653004897 homodimer interface [polypeptide binding]; other site 298653004898 catalytic residue [active] 298653004899 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 298653004900 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 298653004901 putative active site pocket [active] 298653004902 4-fold oligomerization interface [polypeptide binding]; other site 298653004903 metal binding residues [ion binding]; metal-binding site 298653004904 3-fold/trimer interface [polypeptide binding]; other site 298653004905 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 298653004906 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 298653004907 putative active site [active] 298653004908 oxyanion strand; other site 298653004909 catalytic triad [active] 298653004910 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 298653004911 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653004912 Walker A/P-loop; other site 298653004913 ATP binding site [chemical binding]; other site 298653004914 Q-loop/lid; other site 298653004915 ABC transporter signature motif; other site 298653004916 Walker B; other site 298653004917 D-loop; other site 298653004918 H-loop/switch region; other site 298653004919 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 298653004920 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 298653004921 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 298653004922 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 298653004923 catalytic residues [active] 298653004924 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 298653004925 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 298653004926 substrate binding site [chemical binding]; other site 298653004927 glutamase interaction surface [polypeptide binding]; other site 298653004928 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 298653004929 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 298653004930 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653004931 Walker A/P-loop; other site 298653004932 ATP binding site [chemical binding]; other site 298653004933 Q-loop/lid; other site 298653004934 ABC transporter signature motif; other site 298653004935 Walker B; other site 298653004936 D-loop; other site 298653004937 H-loop/switch region; other site 298653004938 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 298653004939 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 298653004940 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653004941 Walker A/P-loop; other site 298653004942 ATP binding site [chemical binding]; other site 298653004943 Q-loop/lid; other site 298653004944 ABC transporter signature motif; other site 298653004945 Walker B; other site 298653004946 D-loop; other site 298653004947 H-loop/switch region; other site 298653004948 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 298653004949 anthranilate synthase component I; Provisional; Region: PRK13571 298653004950 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 298653004951 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 298653004952 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 298653004953 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 298653004954 active site 298653004955 ribulose/triose binding site [chemical binding]; other site 298653004956 phosphate binding site [ion binding]; other site 298653004957 substrate (anthranilate) binding pocket [chemical binding]; other site 298653004958 product (indole) binding pocket [chemical binding]; other site 298653004959 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 298653004960 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 298653004961 pyridoxal 5'-phosphate binding site [chemical binding]; other site 298653004962 catalytic residue [active] 298653004963 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 298653004964 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 298653004965 substrate binding site [chemical binding]; other site 298653004966 active site 298653004967 catalytic residues [active] 298653004968 heterodimer interface [polypeptide binding]; other site 298653004969 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 298653004970 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 298653004971 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 298653004972 active site 298653004973 dimer interface [polypeptide binding]; other site 298653004974 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 298653004975 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 298653004976 active site 298653004977 FMN binding site [chemical binding]; other site 298653004978 substrate binding site [chemical binding]; other site 298653004979 3Fe-4S cluster binding site [ion binding]; other site 298653004980 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 298653004981 domain interface; other site 298653004982 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 298653004983 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 298653004984 adenylate kinase; Reviewed; Region: adk; PRK00279 298653004985 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 298653004986 AMP-binding site [chemical binding]; other site 298653004987 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 298653004988 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 298653004989 active site 298653004990 catalytic site [active] 298653004991 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 298653004992 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 298653004993 tellurite resistance protein terB; Region: terB; cd07176 298653004994 putative metal binding site [ion binding]; other site 298653004995 ADP-specific Phosphofructokinase/Glucokinase conserved region; Region: ADP_PFK_GK; cl14060 298653004996 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 298653004997 putative active site [active] 298653004998 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 298653004999 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 298653005000 heterodimer interface [polypeptide binding]; other site 298653005001 substrate interaction site [chemical binding]; other site 298653005002 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 298653005003 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 298653005004 active site 298653005005 substrate binding site [chemical binding]; other site 298653005006 coenzyme B12 binding site [chemical binding]; other site 298653005007 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 298653005008 B12 binding site [chemical binding]; other site 298653005009 cobalt ligand [ion binding]; other site 298653005010 membrane ATPase/protein kinase; Provisional; Region: PRK09435 298653005011 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 298653005012 Walker A; other site 298653005013 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 298653005014 nucleotide binding site [chemical binding]; other site 298653005015 putative NEF/HSP70 interaction site [polypeptide binding]; other site 298653005016 SBD interface [polypeptide binding]; other site 298653005017 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 298653005018 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653005019 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653005020 active site 298653005021 ATP binding site [chemical binding]; other site 298653005022 substrate binding site [chemical binding]; other site 298653005023 activation loop (A-loop); other site 298653005024 FOG: WD40 repeat [General function prediction only]; Region: COG2319 298653005025 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 298653005026 structural tetrad; other site 298653005027 FOG: WD40 repeat [General function prediction only]; Region: COG2319 298653005028 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653005029 S-adenosylmethionine binding site [chemical binding]; other site 298653005030 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653005031 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653005032 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 298653005033 putative ligand binding site [chemical binding]; other site 298653005034 Domain of unknown function DUF21; Region: DUF21; pfam01595 298653005035 FOG: CBS domain [General function prediction only]; Region: COG0517 298653005036 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 298653005037 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 298653005038 Domain of unknown function DUF21; Region: DUF21; pfam01595 298653005039 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 298653005040 Transporter associated domain; Region: CorC_HlyC; smart01091 298653005041 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 298653005042 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653005043 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653005044 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653005045 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653005046 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 298653005047 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 298653005048 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 298653005049 dimer interface [polypeptide binding]; other site 298653005050 active site 298653005051 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 298653005052 Predicted transcriptional regulator [Transcription]; Region: COG2378 298653005053 HTH domain; Region: HTH_11; pfam08279 298653005054 WYL domain; Region: WYL; pfam13280 298653005055 Radical SAM superfamily; Region: Radical_SAM; pfam04055 298653005056 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 298653005057 nudix motif; other site 298653005058 ABC-2 type transporter; Region: ABC2_membrane; cl11417 298653005059 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 298653005060 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653005061 ABC transporter signature motif; other site 298653005062 Walker B; other site 298653005063 D-loop; other site 298653005064 H-loop/switch region; other site 298653005065 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 298653005066 Probable transposase; Region: OrfB_IS605; pfam01385 298653005067 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 298653005068 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 298653005069 GAF domain; Region: GAF; pfam01590 298653005070 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 298653005071 Histidine kinase; Region: HisKA_3; pfam07730 298653005072 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 298653005073 AAA domain; Region: AAA_33; pfam13671 298653005074 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653005075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653005076 active site 298653005077 phosphorylation site [posttranslational modification] 298653005078 intermolecular recognition site; other site 298653005079 dimerization interface [polypeptide binding]; other site 298653005080 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653005081 DNA binding residues [nucleotide binding] 298653005082 dimerization interface [polypeptide binding]; other site 298653005083 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 298653005084 dimer interface [polypeptide binding]; other site 298653005085 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 298653005086 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 298653005087 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 298653005088 Methyltransferase domain; Region: Methyltransf_23; pfam13489 298653005089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653005090 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 298653005091 Pirin-related protein [General function prediction only]; Region: COG1741 298653005092 Pirin; Region: Pirin; pfam02678 298653005093 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 298653005094 MarR family; Region: MarR_2; pfam12802 298653005095 Domain of unknown function (DUF222); Region: DUF222; pfam02720 298653005096 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 298653005097 active site 298653005098 hypothetical protein; Provisional; Region: PRK06185 298653005099 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653005100 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653005101 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 298653005102 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 298653005103 Walker A motif; other site 298653005104 ATP binding site [chemical binding]; other site 298653005105 Walker B motif; other site 298653005106 arginine finger; other site 298653005107 Peptidase family M41; Region: Peptidase_M41; pfam01434 298653005108 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 298653005109 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 298653005110 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 298653005111 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 298653005112 prephenate dehydratase; Provisional; Region: PRK11899 298653005113 Prephenate dehydratase; Region: PDT; pfam00800 298653005114 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 298653005115 putative L-Phe binding site [chemical binding]; other site 298653005116 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653005117 AAA domain; Region: AAA_23; pfam13476 298653005118 Walker A/P-loop; other site 298653005119 ATP binding site [chemical binding]; other site 298653005120 Lsr2; Region: Lsr2; pfam11774 298653005121 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 298653005122 active site 298653005123 metal binding site [ion binding]; metal-binding site 298653005124 DNA binding site [nucleotide binding] 298653005125 short chain dehydrogenase; Provisional; Region: PRK07062 298653005126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653005127 NAD(P) binding site [chemical binding]; other site 298653005128 active site 298653005129 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 298653005130 Transcriptional regulators [Transcription]; Region: FadR; COG2186 298653005131 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 298653005132 DNA-binding site [nucleotide binding]; DNA binding site 298653005133 FCD domain; Region: FCD; pfam07729 298653005134 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 298653005135 Helix-turn-helix domains; Region: HTH; cl00088 298653005136 CoA binding domain; Region: CoA_binding_2; pfam13380 298653005137 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 298653005138 ATP-grasp domain; Region: ATP-grasp_4; cl03087 298653005139 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 298653005140 WYL domain; Region: WYL; pfam13280 298653005141 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653005142 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 298653005143 active site 298653005144 ATP binding site [chemical binding]; other site 298653005145 substrate binding site [chemical binding]; other site 298653005146 activation loop (A-loop); other site 298653005147 MarR family; Region: MarR; pfam01047 298653005148 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 298653005149 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 298653005150 conserved cys residue [active] 298653005151 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 298653005152 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 298653005153 enoyl-CoA hydratase; Provisional; Region: PRK06210 298653005154 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653005155 substrate binding site [chemical binding]; other site 298653005156 oxyanion hole (OAH) forming residues; other site 298653005157 trimer interface [polypeptide binding]; other site 298653005158 Short repeat of unknown function (DUF308); Region: DUF308; pfam03729 298653005159 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 298653005160 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 298653005161 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 298653005162 enoyl-CoA hydratase; Provisional; Region: PRK06142 298653005163 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653005164 substrate binding site [chemical binding]; other site 298653005165 oxyanion hole (OAH) forming residues; other site 298653005166 trimer interface [polypeptide binding]; other site 298653005167 Domain of unknown function (DUF427); Region: DUF427; cl00998 298653005168 Domain of unknown function (DUF427); Region: DUF427; pfam04248 298653005169 Domain of unknown function (DUF427); Region: DUF427; pfam04248 298653005170 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 298653005171 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 298653005172 active site 298653005173 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 298653005174 catalytic triad [active] 298653005175 dimer interface [polypeptide binding]; other site 298653005176 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653005177 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 298653005178 Amidinotransferase; Region: Amidinotransf; pfam02274 298653005179 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 298653005180 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653005181 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653005182 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 298653005183 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 298653005184 active site 298653005185 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 298653005186 non-prolyl cis peptide bond; other site 298653005187 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653005188 FAD binding domain; Region: FAD_binding_4; pfam01565 298653005189 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 298653005190 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 298653005191 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 298653005192 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 298653005193 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 298653005194 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 298653005195 active site residue [active] 298653005196 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 298653005197 active site residue [active] 298653005198 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653005199 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653005200 active site 298653005201 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653005202 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653005203 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653005204 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 298653005205 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 298653005206 dimerization interface [polypeptide binding]; other site 298653005207 Domain of unknown function (DUF385); Region: DUF385; pfam04075 298653005208 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653005209 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653005210 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653005211 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 298653005212 putative ligand binding site [chemical binding]; other site 298653005213 Carbohydrate-binding module 48 (Isoamylase N-terminal domain); Region: CBM_48; pfam02922 298653005214 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 298653005215 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 298653005216 catalytic site [active] 298653005217 active site 298653005218 Galactose oxidase, central domain; Region: Kelch_3; cl02701 298653005219 Kelch domain; Region: Kelch; smart00612 298653005220 Domain of unknown function (DUF385); Region: DUF385; pfam04075 298653005221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653005222 NAD(P) binding site [chemical binding]; other site 298653005223 active site 298653005224 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653005225 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 298653005226 Methyltransferase domain; Region: Methyltransf_26; pfam13659 298653005227 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 298653005228 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 298653005229 Abi-like protein; Region: Abi_2; pfam07751 298653005230 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 298653005231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653005232 active site 298653005233 phosphorylation site [posttranslational modification] 298653005234 intermolecular recognition site; other site 298653005235 dimerization interface [polypeptide binding]; other site 298653005236 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 298653005237 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 298653005238 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 298653005239 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 298653005240 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 298653005241 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 298653005242 dimerization interface [polypeptide binding]; other site 298653005243 ligand binding site [chemical binding]; other site 298653005244 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 298653005245 TM-ABC transporter signature motif; other site 298653005246 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 298653005247 TM-ABC transporter signature motif; other site 298653005248 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 298653005249 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 298653005250 Walker A/P-loop; other site 298653005251 ATP binding site [chemical binding]; other site 298653005252 Q-loop/lid; other site 298653005253 ABC transporter signature motif; other site 298653005254 Walker B; other site 298653005255 D-loop; other site 298653005256 H-loop/switch region; other site 298653005257 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 298653005258 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 298653005259 Walker A/P-loop; other site 298653005260 ATP binding site [chemical binding]; other site 298653005261 Q-loop/lid; other site 298653005262 ABC transporter signature motif; other site 298653005263 Walker B; other site 298653005264 D-loop; other site 298653005265 H-loop/switch region; other site 298653005266 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 298653005267 CoenzymeA binding site [chemical binding]; other site 298653005268 subunit interaction site [polypeptide binding]; other site 298653005269 PHB binding site; other site 298653005270 DNA polymerase I; Provisional; Region: PRK05755 298653005271 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 298653005272 active site 298653005273 metal binding site 1 [ion binding]; metal-binding site 298653005274 putative 5' ssDNA interaction site; other site 298653005275 metal binding site 3; metal-binding site 298653005276 metal binding site 2 [ion binding]; metal-binding site 298653005277 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 298653005278 putative DNA binding site [nucleotide binding]; other site 298653005279 putative metal binding site [ion binding]; other site 298653005280 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 298653005281 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 298653005282 active site 298653005283 DNA binding site [nucleotide binding] 298653005284 catalytic site [active] 298653005285 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653005286 metal binding site [ion binding]; metal-binding site 298653005287 active site 298653005288 I-site; other site 298653005289 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 298653005290 GAF domain; Region: GAF_2; pfam13185 298653005291 GAF domain; Region: GAF; pfam01590 298653005292 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 298653005293 GAF domain; Region: GAF; pfam01590 298653005294 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653005295 metal binding site [ion binding]; metal-binding site 298653005296 active site 298653005297 I-site; other site 298653005298 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 298653005299 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 298653005300 active site 298653005301 Zn binding site [ion binding]; other site 298653005302 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653005303 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 298653005304 putative ligand binding site [chemical binding]; other site 298653005305 dephospho-CoA kinase; Region: TIGR00152 298653005306 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 298653005307 CoA-binding site [chemical binding]; other site 298653005308 ATP-binding [chemical binding]; other site 298653005309 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653005310 S-adenosylmethionine binding site [chemical binding]; other site 298653005311 excinuclease ABC subunit B; Provisional; Region: PRK05298 298653005312 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 298653005313 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 298653005314 nucleotide binding region [chemical binding]; other site 298653005315 ATP-binding site [chemical binding]; other site 298653005316 Ultra-violet resistance protein B; Region: UvrB; pfam12344 298653005317 UvrB/uvrC motif; Region: UVR; pfam02151 298653005318 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 298653005319 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 298653005320 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 298653005321 WYL domain; Region: WYL; pfam13280 298653005322 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 298653005323 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 298653005324 active site 298653005325 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 298653005326 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 298653005327 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 298653005328 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 298653005329 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 298653005330 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 298653005331 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 298653005332 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 298653005333 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 298653005334 GIY-YIG motif/motif A; other site 298653005335 active site 298653005336 catalytic site [active] 298653005337 putative DNA binding site [nucleotide binding]; other site 298653005338 metal binding site [ion binding]; metal-binding site 298653005339 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 298653005340 Helix-hairpin-helix motif; Region: HHH; pfam00633 298653005341 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 298653005342 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 298653005343 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 298653005344 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 298653005345 phosphate binding site [ion binding]; other site 298653005346 putative substrate binding pocket [chemical binding]; other site 298653005347 dimer interface [polypeptide binding]; other site 298653005348 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 298653005349 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 298653005350 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 298653005351 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 298653005352 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 298653005353 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 298653005354 Phosphoglycerate kinase; Region: PGK; pfam00162 298653005355 substrate binding site [chemical binding]; other site 298653005356 hinge regions; other site 298653005357 ADP binding site [chemical binding]; other site 298653005358 catalytic site [active] 298653005359 triosephosphate isomerase; Provisional; Region: PRK14567 298653005360 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 298653005361 substrate binding site [chemical binding]; other site 298653005362 dimer interface [polypeptide binding]; other site 298653005363 catalytic triad [active] 298653005364 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 298653005365 peptide binding site [polypeptide binding]; other site 298653005366 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 298653005367 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 298653005368 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653005369 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 298653005370 active site 298653005371 ATP binding site [chemical binding]; other site 298653005372 substrate binding site [chemical binding]; other site 298653005373 activation loop (A-loop); other site 298653005374 Short C-terminal domain; Region: SHOCT; pfam09851 298653005375 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 298653005376 putative active site [active] 298653005377 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 298653005378 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 298653005379 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 298653005380 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 298653005381 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 298653005382 putative active site [active] 298653005383 transaldolase; Provisional; Region: PRK03903 298653005384 catalytic residue [active] 298653005385 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 298653005386 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 298653005387 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 298653005388 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653005389 NAD(P) binding site [chemical binding]; other site 298653005390 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 298653005391 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 298653005392 ABC-2 type transporter; Region: ABC2_membrane; cl11417 298653005393 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 298653005394 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 298653005395 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 298653005396 Walker A/P-loop; other site 298653005397 ATP binding site [chemical binding]; other site 298653005398 Q-loop/lid; other site 298653005399 ABC transporter signature motif; other site 298653005400 Walker B; other site 298653005401 D-loop; other site 298653005402 H-loop/switch region; other site 298653005403 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 298653005404 sequence-specific DNA binding site [nucleotide binding]; other site 298653005405 salt bridge; other site 298653005406 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 298653005407 N- and C-terminal domain interface [polypeptide binding]; other site 298653005408 glycerol kinase; Provisional; Region: glpK; PRK00047 298653005409 active site 298653005410 MgATP binding site [chemical binding]; other site 298653005411 catalytic site [active] 298653005412 metal binding site [ion binding]; metal-binding site 298653005413 glycerol binding site [chemical binding]; other site 298653005414 homotetramer interface [polypeptide binding]; other site 298653005415 homodimer interface [polypeptide binding]; other site 298653005416 FBP binding site [chemical binding]; other site 298653005417 protein IIAGlc interface [polypeptide binding]; other site 298653005418 Predicted transcriptional regulator [Transcription]; Region: COG2345 298653005419 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 298653005420 putative DNA binding site [nucleotide binding]; other site 298653005421 putative Zn2+ binding site [ion binding]; other site 298653005422 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 298653005423 FeS assembly protein SufB; Region: sufB; TIGR01980 298653005424 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 298653005425 FeS assembly protein SufD; Region: sufD; TIGR01981 298653005426 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 298653005427 [2Fe-2S] cluster binding site [ion binding]; other site 298653005428 FeS assembly ATPase SufC; Region: sufC; TIGR01978 298653005429 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 298653005430 Walker A/P-loop; other site 298653005431 ATP binding site [chemical binding]; other site 298653005432 Q-loop/lid; other site 298653005433 ABC transporter signature motif; other site 298653005434 Walker B; other site 298653005435 D-loop; other site 298653005436 H-loop/switch region; other site 298653005437 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 298653005438 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 298653005439 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 298653005440 catalytic residue [active] 298653005441 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 298653005442 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 298653005443 trimerization site [polypeptide binding]; other site 298653005444 active site 298653005445 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 298653005446 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 298653005447 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 298653005448 oligomer interface; other site 298653005449 ligand binding site; other site 298653005450 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 298653005451 dimer interface [polypeptide binding]; other site 298653005452 N-terminal domain interface [polypeptide binding]; other site 298653005453 sulfate 1 binding site; other site 298653005454 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 298653005455 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 298653005456 Domain of unknown function (DUF222); Region: DUF222; pfam02720 298653005457 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 298653005458 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 298653005459 NAD binding site [chemical binding]; other site 298653005460 substrate binding site [chemical binding]; other site 298653005461 homodimer interface [polypeptide binding]; other site 298653005462 active site 298653005463 Uncharacterized conserved protein [Function unknown]; Region: COG2308 298653005464 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174 298653005465 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 298653005466 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 298653005467 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 298653005468 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 298653005469 YceI-like domain; Region: YceI; smart00867 298653005470 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 298653005471 Helix-hairpin-helix motif; Region: HHH; pfam00633 298653005472 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 298653005473 Competence protein; Region: Competence; cl00471 298653005474 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 298653005475 hypothetical protein; Reviewed; Region: PRK07914 298653005476 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 298653005477 GTP-binding protein LepA; Provisional; Region: PRK05433 298653005478 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 298653005479 G1 box; other site 298653005480 putative GEF interaction site [polypeptide binding]; other site 298653005481 GTP/Mg2+ binding site [chemical binding]; other site 298653005482 Switch I region; other site 298653005483 G2 box; other site 298653005484 G3 box; other site 298653005485 Switch II region; other site 298653005486 G4 box; other site 298653005487 G5 box; other site 298653005488 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 298653005489 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 298653005490 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 298653005491 coproporphyrinogen III oxidase; Validated; Region: PRK05628 298653005492 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 298653005493 FeS/SAM binding site; other site 298653005494 HemN C-terminal domain; Region: HemN_C; pfam06969 298653005495 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 298653005496 HTH domain; Region: HTH_11; pfam08279 298653005497 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 298653005498 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 298653005499 HSP70 interaction site [polypeptide binding]; other site 298653005500 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 298653005501 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 298653005502 dimer interface [polypeptide binding]; other site 298653005503 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 298653005504 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 298653005505 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 298653005506 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 298653005507 PhoH-like protein; Region: PhoH; pfam02562 298653005508 metal-binding heat shock protein; Provisional; Region: PRK00016 298653005509 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 298653005510 Domain of unknown function DUF21; Region: DUF21; pfam01595 298653005511 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 298653005512 Transporter associated domain; Region: CorC_HlyC; smart01091 298653005513 GTPase Era; Reviewed; Region: era; PRK00089 298653005514 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 298653005515 G1 box; other site 298653005516 GTP/Mg2+ binding site [chemical binding]; other site 298653005517 Switch I region; other site 298653005518 G2 box; other site 298653005519 Switch II region; other site 298653005520 G3 box; other site 298653005521 G4 box; other site 298653005522 G5 box; other site 298653005523 KH domain; Region: KH_2; pfam07650 298653005524 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 298653005525 nudix motif; other site 298653005526 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 298653005527 Recombination protein O N terminal; Region: RecO_N; pfam11967 298653005528 Recombination protein O C terminal; Region: RecO_C; pfam02565 298653005529 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 298653005530 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 298653005531 catalytic residue [active] 298653005532 putative FPP diphosphate binding site; other site 298653005533 putative FPP binding hydrophobic cleft; other site 298653005534 dimer interface [polypeptide binding]; other site 298653005535 putative IPP diphosphate binding site; other site 298653005536 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 298653005537 glycyl-tRNA synthetase; Provisional; Region: PRK14908 298653005538 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 298653005539 motif 1; other site 298653005540 dimer interface [polypeptide binding]; other site 298653005541 active site 298653005542 motif 2; other site 298653005543 motif 3; other site 298653005544 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 298653005545 putative active site [active] 298653005546 transketolase; Reviewed; Region: PRK05899 298653005547 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 298653005548 TPP-binding site [chemical binding]; other site 298653005549 dimer interface [polypeptide binding]; other site 298653005550 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 298653005551 PYR/PP interface [polypeptide binding]; other site 298653005552 dimer interface [polypeptide binding]; other site 298653005553 TPP binding site [chemical binding]; other site 298653005554 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 298653005555 Bacterial PH domain; Region: DUF304; pfam03703 298653005556 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 298653005557 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 298653005558 Zn2+ binding site [ion binding]; other site 298653005559 Mg2+ binding site [ion binding]; other site 298653005560 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 298653005561 DNA primase; Validated; Region: dnaG; PRK05667 298653005562 CHC2 zinc finger; Region: zf-CHC2; pfam01807 298653005563 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 298653005564 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 298653005565 active site 298653005566 metal binding site [ion binding]; metal-binding site 298653005567 interdomain interaction site; other site 298653005568 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 298653005569 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 298653005570 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 298653005571 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 298653005572 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 298653005573 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 298653005574 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 298653005575 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 298653005576 DNA binding residues [nucleotide binding] 298653005577 Methyltransferase domain; Region: Methyltransf_23; pfam13489 298653005578 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653005579 S-adenosylmethionine binding site [chemical binding]; other site 298653005580 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 298653005581 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 298653005582 Methyltransferase domain; Region: Methyltransf_23; pfam13489 298653005583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653005584 S-adenosylmethionine binding site [chemical binding]; other site 298653005585 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 298653005586 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 298653005587 active site 298653005588 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 298653005589 PDGLE domain; Region: PDGLE; pfam13190 298653005590 Cobalt transport protein; Region: CbiQ; cl00463 298653005591 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 298653005592 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 298653005593 Walker A/P-loop; other site 298653005594 ATP binding site [chemical binding]; other site 298653005595 Q-loop/lid; other site 298653005596 ABC transporter signature motif; other site 298653005597 Walker B; other site 298653005598 D-loop; other site 298653005599 H-loop/switch region; other site 298653005600 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 298653005601 active site 298653005602 catalytic site [active] 298653005603 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653005604 metal binding site [ion binding]; metal-binding site 298653005605 active site 298653005606 I-site; other site 298653005607 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 298653005608 Low molecular weight phosphatase family; Region: LMWPc; cl00105 298653005609 active site 298653005610 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653005611 S-adenosylmethionine binding site [chemical binding]; other site 298653005612 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 298653005613 MatE; Region: MatE; cl10513 298653005614 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 298653005615 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 298653005616 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 298653005617 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653005618 S-adenosylmethionine binding site [chemical binding]; other site 298653005619 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 298653005620 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 298653005621 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 298653005622 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 298653005623 Methyltransferase domain; Region: Methyltransf_24; pfam13578 298653005624 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 298653005625 Helix-turn-helix domains; Region: HTH; cl00088 298653005626 Methyltransferase domain; Region: Methyltransf_23; pfam13489 298653005627 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653005628 S-adenosylmethionine binding site [chemical binding]; other site 298653005629 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; cl15759 298653005630 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 298653005631 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 298653005632 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 298653005633 Uncharacterized conserved protein [Function unknown]; Region: COG2006 298653005634 Domain of unknown function (DUF362); Region: DUF362; pfam04015 298653005635 Uncharacterized conserved protein [Function unknown]; Region: COG2006 298653005636 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 298653005637 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 298653005638 NADH(P)-binding; Region: NAD_binding_10; pfam13460 298653005639 putative NAD(P) binding site [chemical binding]; other site 298653005640 active site 298653005641 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 298653005642 putative glycosyl transferase; Provisional; Region: PRK10307 298653005643 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 298653005644 Mg++ binding site [ion binding]; other site 298653005645 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 298653005646 putative catalytic motif [active] 298653005647 putative substrate binding site [chemical binding]; other site 298653005648 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 298653005649 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 298653005650 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 298653005651 putative NAD(P) binding site [chemical binding]; other site 298653005652 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 298653005653 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653005654 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 298653005655 active site 298653005656 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 298653005657 homodimer interface [polypeptide binding]; other site 298653005658 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 298653005659 probable UDP-glucose 6-dehydrogenase; Region: PLN02353 298653005660 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 298653005661 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653005662 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 298653005663 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 298653005664 Probable transposase; Region: OrfB_IS605; pfam01385 298653005665 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 298653005666 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 298653005667 putative ADP-binding pocket [chemical binding]; other site 298653005668 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 298653005669 aconitate hydratase; Validated; Region: PRK09277 298653005670 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 298653005671 substrate binding site [chemical binding]; other site 298653005672 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 298653005673 ligand binding site [chemical binding]; other site 298653005674 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 298653005675 substrate binding site [chemical binding]; other site 298653005676 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 298653005677 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 298653005678 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 298653005679 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 298653005680 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653005681 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 298653005682 Homeodomain-like domain; Region: HTH_23; pfam13384 298653005683 Winged helix-turn helix; Region: HTH_29; pfam13551 298653005684 Homeodomain-like domain; Region: HTH_32; pfam13565 298653005685 DDE superfamily endonuclease; Region: DDE_3; pfam13358 298653005686 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 298653005687 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 298653005688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653005689 active site 298653005690 phosphorylation site [posttranslational modification] 298653005691 intermolecular recognition site; other site 298653005692 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 298653005693 Excalibur calcium-binding domain; Region: Excalibur; cl05460 298653005694 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 298653005695 Domain of unknown function (DUF385); Region: DUF385; pfam04075 298653005696 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 298653005697 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 298653005698 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 298653005699 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 298653005700 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 298653005701 DNA binding site [nucleotide binding] 298653005702 active site 298653005703 Int/Topo IB signature motif; other site 298653005704 catalytic residues [active] 298653005705 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653005706 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653005707 active site 298653005708 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 298653005709 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 298653005710 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 298653005711 Membrane transport protein; Region: Mem_trans; cl09117 298653005712 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 298653005713 Fatty acid desaturase; Region: FA_desaturase; pfam00487 298653005714 Di-iron ligands [ion binding]; other site 298653005715 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 298653005716 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 298653005717 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 298653005718 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 298653005719 adenosine deaminase; Provisional; Region: PRK09358 298653005720 active site 298653005721 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 298653005722 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 298653005723 putative acyl-acceptor binding pocket; other site 298653005724 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 298653005725 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 298653005726 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 298653005727 Uncharacterized conserved protein [Function unknown]; Region: COG2135 298653005728 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 298653005729 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 298653005730 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653005731 Walker A/P-loop; other site 298653005732 ATP binding site [chemical binding]; other site 298653005733 Q-loop/lid; other site 298653005734 ABC transporter signature motif; other site 298653005735 Walker B; other site 298653005736 D-loop; other site 298653005737 H-loop/switch region; other site 298653005738 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 298653005739 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 298653005740 Cation efflux family; Region: Cation_efflux; pfam01545 298653005741 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653005742 trimer interface [polypeptide binding]; other site 298653005743 oxyanion hole (OAH) forming residues; other site 298653005744 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 298653005745 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 298653005746 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653005747 Walker A/P-loop; other site 298653005748 ATP binding site [chemical binding]; other site 298653005749 Q-loop/lid; other site 298653005750 ABC transporter signature motif; other site 298653005751 Walker B; other site 298653005752 D-loop; other site 298653005753 H-loop/switch region; other site 298653005754 pyruvate kinase; Provisional; Region: PRK06247 298653005755 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 298653005756 domain interfaces; other site 298653005757 active site 298653005758 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 298653005759 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 298653005760 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653005761 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 298653005762 DNA binding residues [nucleotide binding] 298653005763 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 298653005764 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 298653005765 catalytic residue [active] 298653005766 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 298653005767 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 298653005768 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 298653005769 hydroxyglutarate oxidase; Provisional; Region: PRK11728 298653005770 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653005771 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 298653005772 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 298653005773 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 298653005774 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 298653005775 TrkA-C domain; Region: TrkA_C; pfam02080 298653005776 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 298653005777 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 298653005778 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 298653005779 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653005780 NAD(P) binding site [chemical binding]; other site 298653005781 active site 298653005782 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 298653005783 TPP-binding site [chemical binding]; other site 298653005784 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 298653005785 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653005786 NAD(P) binding site [chemical binding]; other site 298653005787 active site 298653005788 ferrochelatase; Reviewed; Region: hemH; PRK00035 298653005789 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 298653005790 C-terminal domain interface [polypeptide binding]; other site 298653005791 active site 298653005792 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 298653005793 active site 298653005794 N-terminal domain interface [polypeptide binding]; other site 298653005795 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 298653005796 Predicted transcriptional regulators [Transcription]; Region: COG1695 298653005797 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653005798 Walker A/P-loop; other site 298653005799 ATP binding site [chemical binding]; other site 298653005800 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 298653005801 active site 298653005802 catalytic triad [active] 298653005803 oxyanion hole [active] 298653005804 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 298653005805 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 298653005806 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 298653005807 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 298653005808 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 298653005809 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653005810 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653005811 Uncharacterized conserved protein [Function unknown]; Region: COG1912 298653005812 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 298653005813 urate oxidase; Region: urate_oxi; TIGR03383 298653005814 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 298653005815 active site 298653005816 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 298653005817 Bacterial Ig-like domain; Region: Big_5; pfam13205 298653005818 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 298653005819 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 298653005820 active site 298653005821 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 298653005822 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 298653005823 ligand binding site [chemical binding]; other site 298653005824 Uncharacterized conserved protein [Function unknown]; Region: COG3461 298653005825 Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659 298653005826 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 298653005827 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 298653005828 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 298653005829 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 298653005830 heme binding site [chemical binding]; other site 298653005831 ferroxidase pore; other site 298653005832 ferroxidase diiron center [ion binding]; other site 298653005833 MMPL family; Region: MMPL; pfam03176 298653005834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653005835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653005836 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 298653005837 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 298653005838 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653005839 putative substrate translocation pore; other site 298653005840 Predicted transcriptional regulators [Transcription]; Region: COG1733 298653005841 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 298653005842 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 298653005843 active site 298653005844 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 298653005845 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 298653005846 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 298653005847 ligand binding site [chemical binding]; other site 298653005848 flexible hinge region; other site 298653005849 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653005850 ATP binding site [chemical binding]; other site 298653005851 Mg2+ binding site [ion binding]; other site 298653005852 G-X-G motif; other site 298653005853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653005854 active site 298653005855 phosphorylation site [posttranslational modification] 298653005856 intermolecular recognition site; other site 298653005857 dimerization interface [polypeptide binding]; other site 298653005858 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 298653005859 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 298653005860 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653005861 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 298653005862 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 298653005863 DNA binding residues [nucleotide binding] 298653005864 putative dimer interface [polypeptide binding]; other site 298653005865 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 298653005866 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 298653005867 Rdx family; Region: Rdx; cl01407 298653005868 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 298653005869 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653005870 Walker A/P-loop; other site 298653005871 ATP binding site [chemical binding]; other site 298653005872 Q-loop/lid; other site 298653005873 ABC transporter signature motif; other site 298653005874 Walker B; other site 298653005875 D-loop; other site 298653005876 H-loop/switch region; other site 298653005877 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653005878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653005879 active site 298653005880 phosphorylation site [posttranslational modification] 298653005881 intermolecular recognition site; other site 298653005882 dimerization interface [polypeptide binding]; other site 298653005883 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653005884 DNA binding residues [nucleotide binding] 298653005885 dimerization interface [polypeptide binding]; other site 298653005886 Histidine kinase; Region: HisKA_3; pfam07730 298653005887 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 298653005888 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 298653005889 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 298653005890 Domain of unknown function (DUF427); Region: DUF427; pfam04248 298653005891 Domain of unknown function (DUF427); Region: DUF427; pfam04248 298653005892 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653005893 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 298653005894 Walker A/P-loop; other site 298653005895 ATP binding site [chemical binding]; other site 298653005896 Q-loop/lid; other site 298653005897 ABC transporter signature motif; other site 298653005898 Walker B; other site 298653005899 D-loop; other site 298653005900 H-loop/switch region; other site 298653005901 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 298653005902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653005903 dimer interface [polypeptide binding]; other site 298653005904 conserved gate region; other site 298653005905 putative PBP binding loops; other site 298653005906 ABC-ATPase subunit interface; other site 298653005907 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 298653005908 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 298653005909 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 298653005910 Protein of unknown function (DUF742); Region: DUF742; pfam05331 298653005911 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 298653005912 Nitrate and nitrite sensing; Region: NIT; pfam08376 298653005913 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 298653005914 HAMP domain; Region: HAMP; pfam00672 298653005915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653005916 ATP binding site [chemical binding]; other site 298653005917 Mg2+ binding site [ion binding]; other site 298653005918 G-X-G motif; other site 298653005919 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653005920 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 298653005921 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 298653005922 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 298653005923 Walker A/P-loop; other site 298653005924 ATP binding site [chemical binding]; other site 298653005925 Q-loop/lid; other site 298653005926 ABC transporter signature motif; other site 298653005927 Walker B; other site 298653005928 D-loop; other site 298653005929 H-loop/switch region; other site 298653005930 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 298653005931 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653005932 dimer interface [polypeptide binding]; other site 298653005933 conserved gate region; other site 298653005934 putative PBP binding loops; other site 298653005935 ABC-ATPase subunit interface; other site 298653005936 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 298653005937 active site 298653005938 putative substrate binding pocket [chemical binding]; other site 298653005939 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653005940 active site 298653005941 I-site; other site 298653005942 metal binding site [ion binding]; metal-binding site 298653005943 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 298653005944 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 298653005945 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 298653005946 Transcriptional regulators [Transcription]; Region: FadR; COG2186 298653005947 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 298653005948 DNA-binding site [nucleotide binding]; DNA binding site 298653005949 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 298653005950 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 298653005951 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 298653005952 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 298653005953 dimer interface [polypeptide binding]; other site 298653005954 decamer (pentamer of dimers) interface [polypeptide binding]; other site 298653005955 catalytic triad [active] 298653005956 peroxidatic and resolving cysteines [active] 298653005957 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 298653005958 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 298653005959 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 298653005960 dimerization interface [polypeptide binding]; other site 298653005961 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 298653005962 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 298653005963 Uncharacterized conserved protein [Function unknown]; Region: COG2308 298653005964 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174 298653005965 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 298653005966 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 298653005967 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 298653005968 active site 298653005969 dimer interface [polypeptide binding]; other site 298653005970 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 298653005971 Ligand Binding Site [chemical binding]; other site 298653005972 Molecular Tunnel; other site 298653005973 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 298653005974 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 298653005975 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 298653005976 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 298653005977 Coenzyme A binding pocket [chemical binding]; other site 298653005978 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 298653005979 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 298653005980 Putative sensor; Region: Sensor; pfam13796 298653005981 Histidine kinase; Region: HisKA_3; pfam07730 298653005982 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 298653005983 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653005984 Response regulator receiver domain; Region: Response_reg; pfam00072 298653005985 active site 298653005986 phosphorylation site [posttranslational modification] 298653005987 intermolecular recognition site; other site 298653005988 dimerization interface [polypeptide binding]; other site 298653005989 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 298653005990 DNA binding residues [nucleotide binding] 298653005991 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 298653005992 Pectate lyase; Region: Pectate_lyase; pfam03211 298653005993 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 298653005994 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 298653005995 SpoOM protein; Region: Spo0M; pfam07070 298653005996 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 298653005997 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 298653005998 active site 298653005999 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 298653006000 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 298653006001 active site 298653006002 catalytic tetrad [active] 298653006003 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 298653006004 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 298653006005 putative metal binding site [ion binding]; other site 298653006006 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 298653006007 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 298653006008 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 298653006009 YndJ-like protein; Region: YndJ; pfam14158 298653006010 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 298653006011 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653006012 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 298653006013 TIR domain; Region: TIR_2; pfam13676 298653006014 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653006015 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653006016 DNA binding residues [nucleotide binding] 298653006017 dimerization interface [polypeptide binding]; other site 298653006018 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 298653006019 FOG: WD40 repeat [General function prediction only]; Region: COG2319 298653006020 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 298653006021 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 298653006022 dimerization interface [polypeptide binding]; other site 298653006023 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653006024 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 298653006025 Transcriptional regulator [Transcription]; Region: LysR; COG0583 298653006026 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 298653006027 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 298653006028 dimerization interface [polypeptide binding]; other site 298653006029 substrate binding pocket [chemical binding]; other site 298653006030 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 298653006031 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 298653006032 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 298653006033 CGNR zinc finger; Region: zf-CGNR; pfam11706 298653006034 Major Facilitator Superfamily; Region: MFS_1; pfam07690 298653006035 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 298653006036 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653006037 NAD(P) binding site [chemical binding]; other site 298653006038 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 298653006039 active site 298653006040 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653006041 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653006042 WHG domain; Region: WHG; pfam13305 298653006043 AAA domain; Region: AAA_33; pfam13671 298653006044 AAA domain; Region: AAA_17; pfam13207 298653006045 active site 298653006046 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 298653006047 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653006048 Cupin domain; Region: Cupin_2; cl09118 298653006049 Helix-turn-helix domain; Region: HTH_18; pfam12833 298653006050 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 298653006051 Helix-turn-helix; Region: HTH_3; pfam01381 298653006052 amino acid transporter; Region: 2A0306; TIGR00909 298653006053 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653006054 metal binding site [ion binding]; metal-binding site 298653006055 active site 298653006056 I-site; other site 298653006057 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 298653006058 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653006059 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 298653006060 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 298653006061 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 298653006062 putative active site [active] 298653006063 Methyltransferase domain; Region: Methyltransf_23; pfam13489 298653006064 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653006065 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 298653006066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653006067 active site 298653006068 phosphorylation site [posttranslational modification] 298653006069 intermolecular recognition site; other site 298653006070 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 298653006071 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 298653006072 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 298653006073 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 298653006074 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 298653006075 Uncharacterized conserved protein [Function unknown]; Region: COG2128 298653006076 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 298653006077 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653006078 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 298653006079 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 298653006080 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 298653006081 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 298653006082 DNA binding residues [nucleotide binding] 298653006083 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653006084 Amidohydrolase; Region: Amidohydro_2; pfam04909 298653006085 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 298653006086 DUF35 OB-fold domain; Region: DUF35; pfam01796 298653006087 lipid-transfer protein; Provisional; Region: PRK07855 298653006088 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 298653006089 active site 298653006090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653006091 active site 298653006092 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653006093 NADH(P)-binding; Region: NAD_binding_10; pfam13460 298653006094 NAD(P) binding site [chemical binding]; other site 298653006095 active site 298653006096 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 298653006097 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 298653006098 calcium binding site 2 [ion binding]; other site 298653006099 active site 298653006100 catalytic triad [active] 298653006101 calcium binding site 1 [ion binding]; other site 298653006102 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 298653006103 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 298653006104 Uncharacterized conserved protein [Function unknown]; Region: COG2128 298653006105 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653006106 active site 298653006107 ATP binding site [chemical binding]; other site 298653006108 substrate binding site [chemical binding]; other site 298653006109 activation loop (A-loop); other site 298653006110 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653006111 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653006112 active site 298653006113 ATP binding site [chemical binding]; other site 298653006114 substrate binding site [chemical binding]; other site 298653006115 activation loop (A-loop); other site 298653006116 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 298653006117 L-lysine aminotransferase; Provisional; Region: PRK08297 298653006118 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 298653006119 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 298653006120 catalytic residue [active] 298653006121 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 298653006122 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 298653006123 NAD(P) binding site [chemical binding]; other site 298653006124 catalytic residues [active] 298653006125 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 298653006126 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653006127 S-adenosylmethionine binding site [chemical binding]; other site 298653006128 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 298653006129 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 298653006130 generic binding surface II; other site 298653006131 generic binding surface I; other site 298653006132 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 298653006133 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 298653006134 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 298653006135 catalytic residue [active] 298653006136 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 298653006137 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653006138 ATP binding site [chemical binding]; other site 298653006139 putative Mg++ binding site [ion binding]; other site 298653006140 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 298653006141 nucleotide binding region [chemical binding]; other site 298653006142 ATP-binding site [chemical binding]; other site 298653006143 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 298653006144 Protein of unknown function (DUF445); Region: DUF445; pfam04286 298653006145 Nitrate and nitrite sensing; Region: NIT; pfam08376 298653006146 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 298653006147 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653006148 ATP binding site [chemical binding]; other site 298653006149 Mg2+ binding site [ion binding]; other site 298653006150 G-X-G motif; other site 298653006151 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 298653006152 Protein of unknown function (DUF742); Region: DUF742; pfam05331 298653006153 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 298653006154 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 298653006155 Switch I region; other site 298653006156 G3 box; other site 298653006157 Switch II region; other site 298653006158 GTP/Mg2+ binding site [chemical binding]; other site 298653006159 G4 box; other site 298653006160 G5 box; other site 298653006161 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 298653006162 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 298653006163 DNA binding residues [nucleotide binding] 298653006164 dimerization interface [polypeptide binding]; other site 298653006165 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653006166 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673 298653006167 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 298653006168 N-terminal aromatase/cyclase domain of the multifunctional protein tetracenomycin (TcmN) and related domains; Region: TcmN_ARO-CYC_like; cd08860 298653006169 putative hydrophobic ligand binding site [chemical binding]; other site 298653006170 active site 298653006171 catalytic residues_2 [active] 298653006172 catalytic residues_1 [active] 298653006173 Cupin domain; Region: Cupin_2; pfam07883 298653006174 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 298653006175 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 298653006176 dimer interface [polypeptide binding]; other site 298653006177 active site 298653006178 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 298653006179 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 298653006180 active site 298653006181 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 298653006182 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653006183 NAD(P) binding site [chemical binding]; other site 298653006184 active site 298653006185 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 298653006186 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 298653006187 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 298653006188 catalytic triad [active] 298653006189 Protein of unknown function (DUF429); Region: DUF429; cl12046 298653006190 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 298653006191 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 298653006192 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 298653006193 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 298653006194 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653006195 Walker A/P-loop; other site 298653006196 ATP binding site [chemical binding]; other site 298653006197 Q-loop/lid; other site 298653006198 ABC transporter signature motif; other site 298653006199 Walker B; other site 298653006200 D-loop; other site 298653006201 H-loop/switch region; other site 298653006202 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 298653006203 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 298653006204 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653006205 Walker A/P-loop; other site 298653006206 ATP binding site [chemical binding]; other site 298653006207 Q-loop/lid; other site 298653006208 ABC transporter signature motif; other site 298653006209 Walker B; other site 298653006210 D-loop; other site 298653006211 H-loop/switch region; other site 298653006212 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653006213 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 298653006214 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 298653006215 active site 298653006216 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 298653006217 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653006218 substrate binding site [chemical binding]; other site 298653006219 oxyanion hole (OAH) forming residues; other site 298653006220 trimer interface [polypeptide binding]; other site 298653006221 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 298653006222 DNA binding site [nucleotide binding] 298653006223 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 298653006224 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653006225 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 298653006226 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653006227 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 298653006228 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 298653006229 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 298653006230 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653006231 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 298653006232 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653006233 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653006234 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 298653006235 Family description; Region: UvrD_C_2; cl15862 298653006236 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 298653006237 putative active site [active] 298653006238 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 298653006239 Precorrin-8X methylmutase; Region: CbiC; pfam02570 298653006240 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 298653006241 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 298653006242 active site 298653006243 substrate binding site [chemical binding]; other site 298653006244 Phosphotransferase enzyme family; Region: APH; pfam01636 298653006245 ATP binding site [chemical binding]; other site 298653006246 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830 298653006247 active site 298653006248 ADP/pyrophosphate binding site [chemical binding]; other site 298653006249 dimerization interface [polypeptide binding]; other site 298653006250 allosteric effector site; other site 298653006251 fructose-1,6-bisphosphate binding site; other site 298653006252 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 298653006253 putative active site [active] 298653006254 putative metal binding site [ion binding]; other site 298653006255 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 298653006256 Proline dehydrogenase; Region: Pro_dh; cl03282 298653006257 tellurite resistance protein terB; Region: terB; cd07176 298653006258 putative metal binding site [ion binding]; other site 298653006259 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_30; cd04689 298653006260 nudix motif; other site 298653006261 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653006262 S-adenosylmethionine binding site [chemical binding]; other site 298653006263 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 298653006264 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653006265 Response regulator receiver domain; Region: Response_reg; pfam00072 298653006266 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653006267 active site 298653006268 phosphorylation site [posttranslational modification] 298653006269 intermolecular recognition site; other site 298653006270 dimerization interface [polypeptide binding]; other site 298653006271 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 298653006272 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 298653006273 heme binding site [chemical binding]; other site 298653006274 ferroxidase pore; other site 298653006275 ferroxidase diiron center [ion binding]; other site 298653006276 Predicted esterase [General function prediction only]; Region: COG0400 298653006277 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 298653006278 dimerization interface [polypeptide binding]; other site 298653006279 putative DNA binding site [nucleotide binding]; other site 298653006280 putative Zn2+ binding site [ion binding]; other site 298653006281 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 298653006282 Cation efflux family; Region: Cation_efflux; pfam01545 298653006283 FOG: CBS domain [General function prediction only]; Region: COG0517 298653006284 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 298653006285 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653006286 Part of AAA domain; Region: AAA_19; pfam13245 298653006287 Family description; Region: UvrD_C_2; cl15862 298653006288 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 298653006289 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653006290 active site 298653006291 ATP binding site [chemical binding]; other site 298653006292 substrate binding site [chemical binding]; other site 298653006293 activation loop (A-loop); other site 298653006294 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 298653006295 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 298653006296 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 298653006297 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653006298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653006299 active site 298653006300 phosphorylation site [posttranslational modification] 298653006301 intermolecular recognition site; other site 298653006302 dimerization interface [polypeptide binding]; other site 298653006303 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653006304 DNA binding residues [nucleotide binding] 298653006305 dimerization interface [polypeptide binding]; other site 298653006306 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 298653006307 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 298653006308 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653006309 substrate binding site [chemical binding]; other site 298653006310 oxyanion hole (OAH) forming residues; other site 298653006311 trimer interface [polypeptide binding]; other site 298653006312 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 298653006313 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 298653006314 putative molybdopterin cofactor binding site [chemical binding]; other site 298653006315 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 298653006316 putative molybdopterin cofactor binding site; other site 298653006317 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653006318 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653006319 TIR domain; Region: TIR_2; pfam13676 298653006320 Tetratricopeptide repeat; Region: TPR_10; pfam13374 298653006321 Tetratricopeptide repeat; Region: TPR_10; pfam13374 298653006322 Tetratricopeptide repeat; Region: TPR_10; pfam13374 298653006323 Tetratricopeptide repeat; Region: TPR_10; pfam13374 298653006324 Methyltransferase domain; Region: Methyltransf_23; pfam13489 298653006325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653006326 S-adenosylmethionine binding site [chemical binding]; other site 298653006327 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 298653006328 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 298653006329 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 298653006330 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 298653006331 substrate binding pocket [chemical binding]; other site 298653006332 membrane-bound complex binding site; other site 298653006333 hinge residues; other site 298653006334 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 298653006335 phosphopeptide binding site; other site 298653006336 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 298653006337 metal ion-dependent adhesion site (MIDAS); other site 298653006338 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653006339 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653006340 active site 298653006341 ATP binding site [chemical binding]; other site 298653006342 substrate binding site [chemical binding]; other site 298653006343 activation loop (A-loop); other site 298653006344 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 298653006345 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 298653006346 substrate binding pocket [chemical binding]; other site 298653006347 membrane-bound complex binding site; other site 298653006348 hinge residues; other site 298653006349 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 298653006350 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 298653006351 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 298653006352 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 298653006353 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 298653006354 motif II; other site 298653006355 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 298653006356 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 298653006357 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 298653006358 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 298653006359 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 298653006360 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 298653006361 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 298653006362 CopC domain; Region: CopC; pfam04234 298653006363 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653006364 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 298653006365 Transcriptional regulator [Transcription]; Region: LysR; COG0583 298653006366 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 298653006367 LysR substrate binding domain; Region: LysR_substrate; pfam03466 298653006368 dimerization interface [polypeptide binding]; other site 298653006369 Major Facilitator Superfamily; Region: MFS_1; pfam07690 298653006370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653006371 putative substrate translocation pore; other site 298653006372 Protein of unknown function DUF43; Region: DUF43; pfam01861 298653006373 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 298653006374 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 298653006375 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 298653006376 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 298653006377 FMN binding site [chemical binding]; other site 298653006378 dimer interface [polypeptide binding]; other site 298653006379 [NiFe] hydrogenase maturation protein HypF; Region: hypF; TIGR00143 298653006380 HypF finger; Region: zf-HYPF; pfam07503 298653006381 HypF finger; Region: zf-HYPF; pfam07503 298653006382 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 298653006383 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653006384 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 298653006385 hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418 298653006386 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 298653006387 dimerization interface [polypeptide binding]; other site 298653006388 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 298653006389 ATP binding site [chemical binding]; other site 298653006390 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 298653006391 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409 298653006392 HupF/HypC family; Region: HupF_HypC; pfam01455 298653006393 Putative [NiFe] hydrogenase-specific C-terminal protease. Sequence comparison shows similarity to hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). Maturation of [FeNi] hydrogenases includes formation of...; Region: H2MP_like-1; cd06068 298653006394 nickel binding site [ion binding]; other site 298653006395 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 298653006396 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 298653006397 HupF/HypC family; Region: HupF_HypC; cl00394 298653006398 NAD-dependent deacetylase; Provisional; Region: PRK00481 298653006399 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 298653006400 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 298653006401 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 298653006402 Coenzyme A binding pocket [chemical binding]; other site 298653006403 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653006404 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653006405 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653006406 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 298653006407 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 298653006408 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 298653006409 TPP-binding site [chemical binding]; other site 298653006410 tetramer interface [polypeptide binding]; other site 298653006411 heterodimer interface [polypeptide binding]; other site 298653006412 phosphorylation loop region [posttranslational modification] 298653006413 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653006414 enoyl-CoA hydratase; Provisional; Region: PRK06688 298653006415 substrate binding site [chemical binding]; other site 298653006416 oxyanion hole (OAH) forming residues; other site 298653006417 trimer interface [polypeptide binding]; other site 298653006418 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 298653006419 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 298653006420 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 298653006421 NAD(P) binding site [chemical binding]; other site 298653006422 catalytic residues [active] 298653006423 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 298653006424 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653006425 active site 298653006426 phosphorylation site [posttranslational modification] 298653006427 intermolecular recognition site; other site 298653006428 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653006429 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653006430 active site 298653006431 phosphorylation site [posttranslational modification] 298653006432 intermolecular recognition site; other site 298653006433 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653006434 DNA binding residues [nucleotide binding] 298653006435 dimerization interface [polypeptide binding]; other site 298653006436 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 298653006437 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 298653006438 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 298653006439 dimer interface [polypeptide binding]; other site 298653006440 substrate binding site [chemical binding]; other site 298653006441 metal binding site [ion binding]; metal-binding site 298653006442 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 298653006443 lysozyme catalytic cleft [active] 298653006444 lysozyme catalytic site [active] 298653006445 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 298653006446 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 298653006447 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 298653006448 dimer interface [polypeptide binding]; other site 298653006449 active site 298653006450 glycine-pyridoxal phosphate binding site [chemical binding]; other site 298653006451 folate binding site [chemical binding]; other site 298653006452 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 298653006453 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_9; cd08496 298653006454 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 298653006455 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653006456 dimer interface [polypeptide binding]; other site 298653006457 conserved gate region; other site 298653006458 putative PBP binding loops; other site 298653006459 ABC-ATPase subunit interface; other site 298653006460 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 298653006461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653006462 dimer interface [polypeptide binding]; other site 298653006463 conserved gate region; other site 298653006464 putative PBP binding loops; other site 298653006465 ABC-ATPase subunit interface; other site 298653006466 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 298653006467 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 298653006468 Walker A/P-loop; other site 298653006469 ATP binding site [chemical binding]; other site 298653006470 Q-loop/lid; other site 298653006471 ABC transporter signature motif; other site 298653006472 Walker B; other site 298653006473 D-loop; other site 298653006474 H-loop/switch region; other site 298653006475 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 298653006476 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 298653006477 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 298653006478 Walker A/P-loop; other site 298653006479 ATP binding site [chemical binding]; other site 298653006480 Q-loop/lid; other site 298653006481 ABC transporter signature motif; other site 298653006482 Walker B; other site 298653006483 D-loop; other site 298653006484 H-loop/switch region; other site 298653006485 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 298653006486 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 298653006487 active site 298653006488 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 298653006489 dimer interface [polypeptide binding]; other site 298653006490 non-prolyl cis peptide bond; other site 298653006491 insertion regions; other site 298653006492 hypothetical protein; Provisional; Region: PRK06208 298653006493 intersubunit interface [polypeptide binding]; other site 298653006494 active site 298653006495 Zn2+ binding site [ion binding]; other site 298653006496 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653006497 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 298653006498 putative catalytic residues [active] 298653006499 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 298653006500 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653006501 NAD(P) binding site [chemical binding]; other site 298653006502 active site 298653006503 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 298653006504 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 298653006505 active site 298653006506 iron coordination sites [ion binding]; other site 298653006507 substrate binding pocket [chemical binding]; other site 298653006508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653006509 Major Facilitator Superfamily; Region: MFS_1; pfam07690 298653006510 putative substrate translocation pore; other site 298653006511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653006512 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 298653006513 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 298653006514 putative active site [active] 298653006515 putative metal binding site [ion binding]; other site 298653006516 GAF domain; Region: GAF; pfam01590 298653006517 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 298653006518 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 298653006519 DDE domain; Region: DDE_Tnp_IS240; pfam13610 298653006520 heat shock protein HtpX; Provisional; Region: PRK02391 298653006521 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 298653006522 Snf7; Region: Snf7; cl02305 298653006523 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 298653006524 Transposase [DNA replication, recombination, and repair]; Region: COG5421 298653006525 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 298653006526 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 298653006527 catalytic residues [active] 298653006528 catalytic nucleophile [active] 298653006529 Recombinase; Region: Recombinase; pfam07508 298653006530 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 298653006531 Recombinase; Region: Recombinase; pfam07508 298653006532 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 298653006533 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 298653006534 active site 298653006535 DNA binding site [nucleotide binding] 298653006536 Int/Topo IB signature motif; other site 298653006537 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 298653006538 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 298653006539 PrgI family protein; Region: PrgI; pfam12666 298653006540 Domain of unknown function DUF87; Region: DUF87; pfam01935 298653006541 AAA-like domain; Region: AAA_10; pfam12846 298653006542 AAA-like domain; Region: AAA_10; pfam12846 298653006543 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 298653006544 Replication-relaxation; Region: Replic_Relax; pfam13814 298653006545 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 298653006546 N-acetyl-D-glucosamine binding site [chemical binding]; other site 298653006547 catalytic residue [active] 298653006548 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 298653006549 NlpC/P60 family; Region: NLPC_P60; pfam00877 298653006550 CHAT domain; Region: CHAT; pfam12770 298653006551 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 298653006552 NlpC/P60 family; Region: NLPC_P60; pfam00877 298653006553 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 298653006554 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 298653006555 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653006556 non-specific DNA binding site [nucleotide binding]; other site 298653006557 salt bridge; other site 298653006558 sequence-specific DNA binding site [nucleotide binding]; other site 298653006559 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 298653006560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 298653006561 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl02940 298653006562 DNA polymerase III beta subunit; Region: POL3Bc; smart00480 298653006563 putative DNA binding surface [nucleotide binding]; other site 298653006564 dimer interface [polypeptide binding]; other site 298653006565 beta-clamp/clamp loader binding surface; other site 298653006566 beta-clamp/translesion DNA polymerase binding surface; other site 298653006567 phage/plasmid-like protein TIGR03299; Region: LGT_TIGR03299 298653006568 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653006569 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 298653006570 Predicted transcriptional regulators [Transcription]; Region: COG1733 298653006571 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 298653006572 Bacterial transcriptional activator domain; Region: BTAD; smart01043 298653006573 TadE-like protein; Region: TadE; cl10688 298653006574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653006575 S-adenosylmethionine binding site [chemical binding]; other site 298653006576 Type II/IV secretion system protein; Region: T2SE; pfam00437 298653006577 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 298653006578 ATP binding site [chemical binding]; other site 298653006579 Walker A motif; other site 298653006580 hexamer interface [polypeptide binding]; other site 298653006581 Walker B motif; other site 298653006582 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 298653006583 active site 298653006584 dimerization interface [polypeptide binding]; other site 298653006585 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 298653006586 putative catalytic site [active] 298653006587 putative phosphate binding site [ion binding]; other site 298653006588 putative metal binding site [ion binding]; other site 298653006589 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 298653006590 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 298653006591 active site 298653006592 catalytic tetrad [active] 298653006593 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 298653006594 B12 binding site [chemical binding]; other site 298653006595 Radical SAM superfamily; Region: Radical_SAM; pfam04055 298653006596 TSCPD domain; Region: TSCPD; cl14834 298653006597 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 298653006598 glycine dehydrogenase; Provisional; Region: PRK05367 298653006599 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 298653006600 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 298653006601 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 298653006602 Transposase; Region: HTH_Tnp_1; pfam01527 298653006603 DNA-binding interface [nucleotide binding]; DNA binding site 298653006604 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 298653006605 nudix motif; other site 298653006606 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 298653006607 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 298653006608 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653006609 AAA domain; Region: AAA_28; pfam13521 298653006610 active site 298653006611 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 298653006612 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 298653006613 FeS/SAM binding site; other site 298653006614 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 298653006615 active site 298653006616 dimer interface [polypeptide binding]; other site 298653006617 motif 1; other site 298653006618 motif 2; other site 298653006619 motif 3; other site 298653006620 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 298653006621 anticodon binding site; other site 298653006622 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653006623 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 298653006624 aromatic arch; other site 298653006625 DCoH dimer interaction site [polypeptide binding]; other site 298653006626 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 298653006627 DCoH tetramer interaction site [polypeptide binding]; other site 298653006628 substrate binding site [chemical binding]; other site 298653006629 protein-L-isoaspartate O-methyltransferase; Provisional; Region: PRK13944 298653006630 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 298653006631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653006632 S-adenosylmethionine binding site [chemical binding]; other site 298653006633 Methyltransferase domain; Region: Methyltransf_11; pfam08241 298653006634 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 298653006635 nudix motif; other site 298653006636 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 298653006637 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 298653006638 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 298653006639 hypothetical protein; Provisional; Region: PRK06762 298653006640 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 298653006641 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 298653006642 active site 298653006643 DNA binding site [nucleotide binding] 298653006644 Int/Topo IB signature motif; other site 298653006645 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 298653006646 AAA domain; Region: AAA_22; pfam13401 298653006647 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653006648 Walker A motif; other site 298653006649 ATP binding site [chemical binding]; other site 298653006650 Walker B motif; other site 298653006651 Family description; Region: UvrD_C_2; pfam13538 298653006652 Transposase [DNA replication, recombination, and repair]; Region: COG5421 298653006653 Transposase [DNA replication, recombination, and repair]; Region: COG5421 298653006654 Nuclease-related domain; Region: NERD; pfam08378 298653006655 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 298653006656 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653006657 non-specific DNA binding site [nucleotide binding]; other site 298653006658 salt bridge; other site 298653006659 sequence-specific DNA binding site [nucleotide binding]; other site 298653006660 Antirestriction protein (ArdA); Region: ArdA; pfam07275 298653006661 Integrase core domain; Region: rve; cl01316 298653006662 patatin-related protein; Region: TIGR03607 298653006663 Patatin-like phospholipase; Region: Patatin; pfam01734 298653006664 nucleophile elbow; other site 298653006665 Animal heme oxidases similar to plant pathogen-inducible oxygenases; Region: PIOX_like; cd09818 298653006666 putative heme binding site [chemical binding]; other site 298653006667 putative active site [active] 298653006668 putative substrate binding site [chemical binding]; other site 298653006669 choline dehydrogenase; Region: betA; TIGR01810 298653006670 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 298653006671 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 298653006672 deoxyguanosinetriphosphate triphosphohydrolase, putative; Region: dGTP_triPase; TIGR01353 298653006673 Amidohydrolase; Region: Amidohydro_2; pfam04909 298653006674 AMP-binding domain protein; Validated; Region: PRK08315 298653006675 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653006676 Putative cyclase; Region: Cyclase; pfam04199 298653006677 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653006678 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 298653006679 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 298653006680 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653006681 metal binding site [ion binding]; metal-binding site 298653006682 active site 298653006683 I-site; other site 298653006684 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 298653006685 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653006686 metal binding site [ion binding]; metal-binding site 298653006687 active site 298653006688 I-site; other site 298653006689 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 298653006690 active site 1 [active] 298653006691 active site 2 [active] 298653006692 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 298653006693 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653006694 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653006695 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 298653006696 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 298653006697 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 298653006698 enoyl-CoA hydratase; Provisional; Region: PRK06142 298653006699 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653006700 substrate binding site [chemical binding]; other site 298653006701 oxyanion hole (OAH) forming residues; other site 298653006702 trimer interface [polypeptide binding]; other site 298653006703 Amidohydrolase; Region: Amidohydro_2; pfam04909 298653006704 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653006705 enoyl-CoA hydratase; Provisional; Region: PRK06210 298653006706 substrate binding site [chemical binding]; other site 298653006707 oxyanion hole (OAH) forming residues; other site 298653006708 trimer interface [polypeptide binding]; other site 298653006709 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653006710 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 298653006711 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653006712 AMP-binding enzyme; Region: AMP-binding; cl15778 298653006713 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653006714 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 298653006715 putative ligand binding site [chemical binding]; other site 298653006716 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 298653006717 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653006718 NAD(P) binding site [chemical binding]; other site 298653006719 active site 298653006720 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653006721 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 298653006722 putative ligand binding site [chemical binding]; other site 298653006723 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653006724 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653006725 active site 298653006726 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 298653006727 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 298653006728 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653006729 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653006730 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653006731 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 298653006732 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653006733 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 298653006734 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 298653006735 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653006736 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653006737 active site 298653006738 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653006739 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653006740 active site 298653006741 Amidohydrolase; Region: Amidohydro_2; pfam04909 298653006742 enoyl-CoA hydratase; Provisional; Region: PRK08290 298653006743 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653006744 substrate binding site [chemical binding]; other site 298653006745 oxyanion hole (OAH) forming residues; other site 298653006746 trimer interface [polypeptide binding]; other site 298653006747 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653006748 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653006749 active site 298653006750 putative acyltransferase; Provisional; Region: PRK05790 298653006751 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 298653006752 dimer interface [polypeptide binding]; other site 298653006753 active site 298653006754 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 298653006755 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653006756 NAD(P) binding site [chemical binding]; other site 298653006757 active site 298653006758 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 298653006759 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 298653006760 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 298653006761 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653006762 AMP-binding enzyme; Region: AMP-binding; cl15778 298653006763 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 298653006764 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 298653006765 NAD binding site [chemical binding]; other site 298653006766 catalytic residues [active] 298653006767 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 298653006768 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653006769 NAD(P) binding site [chemical binding]; other site 298653006770 active site 298653006771 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653006772 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653006773 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653006774 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 298653006775 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 298653006776 active site 298653006777 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653006778 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653006779 active site 298653006780 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653006781 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 298653006782 SnoaL-like domain; Region: SnoaL_4; pfam13577 298653006783 enoyl-CoA hydratase; Provisional; Region: PRK08252 298653006784 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653006785 substrate binding site [chemical binding]; other site 298653006786 oxyanion hole (OAH) forming residues; other site 298653006787 trimer interface [polypeptide binding]; other site 298653006788 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653006789 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 298653006790 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 298653006791 dimer interface [polypeptide binding]; other site 298653006792 active site 298653006793 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 298653006794 CHAT domain; Region: CHAT; pfam12770 298653006795 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 298653006796 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 298653006797 catalytic residues [active] 298653006798 catalytic nucleophile [active] 298653006799 Recombinase; Region: Recombinase; pfam07508 298653006800 Recombinase; Region: Recombinase; pfam07508 298653006801 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 298653006802 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 298653006803 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 298653006804 active site 298653006805 DNA binding site [nucleotide binding] 298653006806 Int/Topo IB signature motif; other site 298653006807 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 298653006808 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 298653006809 DDE superfamily endonuclease; Region: DDE_5; pfam13546 298653006810 PrgI family protein; Region: PrgI; pfam12666 298653006811 Domain of unknown function DUF87; Region: DUF87; pfam01935 298653006812 AAA-like domain; Region: AAA_10; pfam12846 298653006813 Domain of unknown function DUF87; Region: DUF87; pfam01935 298653006814 AAA-like domain; Region: AAA_10; pfam12846 298653006815 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 298653006816 Replication-relaxation; Region: Replic_Relax; pfam13814 298653006817 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 298653006818 N-acetyl-D-glucosamine binding site [chemical binding]; other site 298653006819 catalytic residue [active] 298653006820 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 298653006821 NlpC/P60 family; Region: NLPC_P60; pfam00877 298653006822 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 298653006823 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653006824 NAD(P) binding site [chemical binding]; other site 298653006825 active site 298653006826 Predicted transcriptional regulators [Transcription]; Region: COG1733 298653006827 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 298653006828 NlpC/P60 family; Region: NLPC_P60; pfam00877 298653006829 TIR domain; Region: TIR_2; pfam13676 298653006830 AAA ATPase domain; Region: AAA_16; pfam13191 298653006831 Walker A/P-loop; other site 298653006832 ATP binding site [chemical binding]; other site 298653006833 Q-loop/lid; other site 298653006834 FOG: WD40 repeat [General function prediction only]; Region: COG2319 298653006835 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 298653006836 structural tetrad; other site 298653006837 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 298653006838 structural tetrad; other site 298653006839 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 298653006840 Transposase; Region: HTH_Tnp_1; pfam01527 298653006841 HTH-like domain; Region: HTH_21; pfam13276 298653006842 Integrase core domain; Region: rve; pfam00665 298653006843 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 298653006844 Transposase; Region: HTH_Tnp_1; pfam01527 298653006845 Homeodomain-like domain; Region: HTH_23; pfam13384 298653006846 Winged helix-turn helix; Region: HTH_29; pfam13551 298653006847 Homeodomain-like domain; Region: HTH_32; pfam13565 298653006848 DDE superfamily endonuclease; Region: DDE_3; pfam13358 298653006849 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 298653006850 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 298653006851 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 298653006852 putative active site [active] 298653006853 putative metal-binding site [ion binding]; other site 298653006854 HNH endonuclease; Region: HNH_2; pfam13391 298653006855 active site 298653006856 FOG: WD40 repeat [General function prediction only]; Region: COG2319 298653006857 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 298653006858 structural tetrad; other site 298653006859 FOG: WD40 repeat [General function prediction only]; Region: COG2319 298653006860 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 298653006861 structural tetrad; other site 298653006862 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 298653006863 structural tetrad; other site 298653006864 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 298653006865 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 298653006866 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 298653006867 putative metal binding site [ion binding]; other site 298653006868 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 298653006869 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 298653006870 DDE superfamily endonuclease; Region: DDE_4; pfam13359 298653006871 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 298653006872 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653006873 non-specific DNA binding site [nucleotide binding]; other site 298653006874 salt bridge; other site 298653006875 sequence-specific DNA binding site [nucleotide binding]; other site 298653006876 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 298653006877 Replication-relaxation; Region: Replic_Relax; pfam13814 298653006878 CHAT domain; Region: CHAT; pfam12770 298653006879 FOG: WD40 repeat [General function prediction only]; Region: COG2319 298653006880 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 298653006881 structural tetrad; other site 298653006882 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 298653006883 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 298653006884 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 298653006885 catalytic nucleophile [active] 298653006886 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 298653006887 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 298653006888 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 298653006889 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 298653006890 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 298653006891 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 298653006892 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 298653006893 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 298653006894 LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793 298653006895 active site 298653006896 zinc binding site [ion binding]; other site 298653006897 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 298653006898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653006899 S-adenosylmethionine binding site [chemical binding]; other site 298653006900 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 298653006901 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 298653006902 catalytic motif [active] 298653006903 Zn binding site [ion binding]; other site 298653006904 Phosphotransferase enzyme family; Region: APH; pfam01636 298653006905 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 298653006906 active site 298653006907 substrate binding site [chemical binding]; other site 298653006908 ATP binding site [chemical binding]; other site 298653006909 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 298653006910 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 298653006911 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 298653006912 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 298653006913 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 298653006914 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 298653006915 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 298653006916 active site 298653006917 Int/Topo IB signature motif; other site 298653006918 DNA binding site [nucleotide binding] 298653006919 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 298653006920 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 298653006921 nudix motif; other site 298653006922 acyl-CoA synthetase; Validated; Region: PRK06188 298653006923 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653006924 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653006925 S-adenosylmethionine binding site [chemical binding]; other site 298653006926 active site 298653006927 NAD+ binding site [chemical binding]; other site 298653006928 oligomerization interface [polypeptide binding]; other site 298653006929 S-adenosyl-L-homocysteine hydrolase, NAD binding domain; Region: AdoHcyase_NAD; smart00997 298653006930 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 298653006931 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653006932 active site 298653006933 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 298653006934 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 298653006935 FeS/SAM binding site; other site 298653006936 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 298653006937 thymidylate kinase; Region: DTMP_kinase; TIGR00041 298653006938 TMP-binding site; other site 298653006939 ATP-binding site [chemical binding]; other site 298653006940 Phosphotransferase enzyme family; Region: APH; pfam01636 298653006941 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 298653006942 active site 298653006943 ATP binding site [chemical binding]; other site 298653006944 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 298653006945 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653006946 active site 298653006947 Poxvirus A32 protein; Region: Pox_A32; pfam04665 298653006948 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140 298653006949 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 298653006950 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 298653006951 motif II; other site 298653006952 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 298653006953 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 298653006954 substrate binding site [chemical binding]; other site 298653006955 hexamer interface [polypeptide binding]; other site 298653006956 metal binding site [ion binding]; metal-binding site 298653006957 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 298653006958 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 298653006959 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 298653006960 Ligand Binding Site [chemical binding]; other site 298653006961 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963 298653006962 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 298653006963 FeS/SAM binding site; other site 298653006964 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 298653006965 active site 298653006966 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 298653006967 aromatic arch; other site 298653006968 DCoH dimer interaction site [polypeptide binding]; other site 298653006969 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 298653006970 DCoH tetramer interaction site [polypeptide binding]; other site 298653006971 substrate binding site [chemical binding]; other site 298653006972 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 298653006973 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 298653006974 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 298653006975 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653006976 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 298653006977 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 298653006978 Integrase core domain; Region: rve; pfam00665 298653006979 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 298653006980 Integrase core domain; Region: rve; pfam00665 298653006981 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653006982 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 298653006983 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 298653006984 conserved cys residue [active] 298653006985 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 298653006986 Transposase [DNA replication, recombination, and repair]; Region: COG5421 298653006987 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 298653006988 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 298653006989 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 298653006990 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 298653006991 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 298653006992 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 298653006993 conserved cys residue [active] 298653006994 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 298653006995 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 298653006996 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653006997 NAD(P) binding site [chemical binding]; other site 298653006998 active site 298653006999 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 298653007000 putative hydrophobic ligand binding site [chemical binding]; other site 298653007001 protein interface [polypeptide binding]; other site 298653007002 gate; other site 298653007003 Amidohydrolase; Region: Amidohydro_2; pfam04909 298653007004 Domain of unknown function DUF59; Region: DUF59; cl00941 298653007005 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653007006 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 298653007007 substrate binding pocket [chemical binding]; other site 298653007008 acyl-CoA synthetase; Validated; Region: PRK06188 298653007009 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653007010 AMP-binding enzyme; Region: AMP-binding; cl15778 298653007011 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 298653007012 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 298653007013 putative NAD(P) binding site [chemical binding]; other site 298653007014 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 298653007015 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 298653007016 putative NAD(P) binding site [chemical binding]; other site 298653007017 Predicted transcriptional regulators [Transcription]; Region: COG1733 298653007018 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 298653007019 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 298653007020 Major Facilitator Superfamily; Region: MFS_1; pfam07690 298653007021 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653007022 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653007023 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 298653007024 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653007025 Predicted transcriptional regulators [Transcription]; Region: COG1733 298653007026 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 298653007027 NADH(P)-binding; Region: NAD_binding_10; pfam13460 298653007028 NAD binding site [chemical binding]; other site 298653007029 substrate binding site [chemical binding]; other site 298653007030 putative active site [active] 298653007031 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 298653007032 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 298653007033 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 298653007034 Integrase core domain; Region: rve; pfam00665 298653007035 DDE domain; Region: DDE_Tnp_IS240; pfam13610 298653007036 Transposase, Mutator family; Region: Transposase_mut; pfam00872 298653007037 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 298653007038 DDE superfamily endonuclease; Region: DDE_5; pfam13546 298653007039 Homeodomain-like domain; Region: HTH_23; pfam13384 298653007040 Winged helix-turn helix; Region: HTH_29; pfam13551 298653007041 Homeodomain-like domain; Region: HTH_32; pfam13565 298653007042 DDE superfamily endonuclease; Region: DDE_3; pfam13358 298653007043 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 298653007044 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 298653007045 putative active site [active] 298653007046 putative NTP binding site [chemical binding]; other site 298653007047 putative nucleic acid binding site [nucleotide binding]; other site 298653007048 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 298653007049 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 298653007050 active site 298653007051 catalytic residues [active] 298653007052 metal binding site [ion binding]; metal-binding site 298653007053 DmpG-like communication domain; Region: DmpG_comm; pfam07836 298653007054 acetaldehyde dehydrogenase; Validated; Region: PRK08300 298653007055 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 298653007056 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 298653007057 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 298653007058 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 298653007059 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 298653007060 Winged helix-turn helix; Region: HTH_29; pfam13551 298653007061 Helix-turn-helix domain; Region: HTH_28; pfam13518 298653007062 Integrase core domain; Region: rve; cl01316 298653007063 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653007064 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 298653007065 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 298653007066 putative active site [active] 298653007067 Fe(II) binding site [ion binding]; other site 298653007068 putative dimer interface [polypeptide binding]; other site 298653007069 putative tetramer interface [polypeptide binding]; other site 298653007070 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 298653007071 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 298653007072 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653007073 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 298653007074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653007075 Major Facilitator Superfamily; Region: MFS_1; pfam07690 298653007076 putative substrate translocation pore; other site 298653007077 SnoaL-like domain; Region: SnoaL_4; pfam13577 298653007078 3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837 298653007079 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 298653007080 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653007081 classical (c) SDRs; Region: SDR_c; cd05233 298653007082 NAD(P) binding site [chemical binding]; other site 298653007083 active site 298653007084 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 298653007085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653007086 metabolite-proton symporter; Region: 2A0106; TIGR00883 298653007087 putative substrate translocation pore; other site 298653007088 Transcriptional regulator [Transcription]; Region: IclR; COG1414 298653007089 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 298653007090 DDE superfamily endonuclease; Region: DDE_5; pfam13546 298653007091 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 298653007092 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653007093 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 298653007094 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 298653007095 FMN binding site [chemical binding]; other site 298653007096 dimer interface [polypeptide binding]; other site 298653007097 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653007098 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 298653007099 active site 298653007100 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653007101 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653007102 active site 298653007103 Amidohydrolase; Region: Amidohydro_2; pfam04909 298653007104 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653007105 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 298653007106 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653007107 NAD(P) binding site [chemical binding]; other site 298653007108 active site 298653007109 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653007110 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 298653007111 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 298653007112 classical (c) SDRs; Region: SDR_c; cd05233 298653007113 NAD(P) binding site [chemical binding]; other site 298653007114 active site 298653007115 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 298653007116 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653007117 NAD(P) binding site [chemical binding]; other site 298653007118 active site 298653007119 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653007120 enoyl-CoA hydratase; Provisional; Region: PRK06210 298653007121 substrate binding site [chemical binding]; other site 298653007122 trimer interface [polypeptide binding]; other site 298653007123 oxyanion hole (OAH) forming residues; other site 298653007124 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 298653007125 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653007126 SnoaL-like domain; Region: SnoaL_4; pfam13577 298653007127 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653007128 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653007129 active site 298653007130 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653007131 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 298653007132 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 298653007133 active site 298653007134 enoyl-CoA hydratase; Provisional; Region: PRK08290 298653007135 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653007136 substrate binding site [chemical binding]; other site 298653007137 oxyanion hole (OAH) forming residues; other site 298653007138 trimer interface [polypeptide binding]; other site 298653007139 mycothiol-dependent formaldehyde dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 298653007140 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 298653007141 NAD binding site [chemical binding]; other site 298653007142 catalytic Zn binding site [ion binding]; other site 298653007143 substrate binding site [chemical binding]; other site 298653007144 structural Zn binding site [ion binding]; other site 298653007145 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 298653007146 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 298653007147 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 298653007148 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 298653007149 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 298653007150 putative active site [active] 298653007151 putative NTP binding site [chemical binding]; other site 298653007152 putative nucleic acid binding site [nucleotide binding]; other site 298653007153 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 298653007154 active site 298653007155 DDE superfamily endonuclease; Region: DDE_5; cl02413 298653007156 Integrase core domain; Region: rve; cl01316 298653007157 Winged helix-turn helix; Region: HTH_29; pfam13551 298653007158 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 298653007159 PAS domain; Region: PAS_9; pfam13426 298653007160 putative active site [active] 298653007161 heme pocket [chemical binding]; other site 298653007162 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653007163 metal binding site [ion binding]; metal-binding site 298653007164 active site 298653007165 I-site; other site 298653007166 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 298653007167 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 298653007168 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 298653007169 AsnC family; Region: AsnC_trans_reg; pfam01037 298653007170 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 298653007171 classical (c) SDRs; Region: SDR_c; cd05233 298653007172 NAD(P) binding site [chemical binding]; other site 298653007173 active site 298653007174 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 298653007175 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 298653007176 NAD(P) binding site [chemical binding]; other site 298653007177 catalytic residues [active] 298653007178 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 298653007179 putative hydrophobic ligand binding site [chemical binding]; other site 298653007180 protein interface [polypeptide binding]; other site 298653007181 gate; other site 298653007182 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 298653007183 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653007184 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653007185 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653007186 active site 298653007187 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 298653007188 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 298653007189 dimer interface [polypeptide binding]; other site 298653007190 active site 298653007191 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 298653007192 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653007193 substrate binding site [chemical binding]; other site 298653007194 oxyanion hole (OAH) forming residues; other site 298653007195 trimer interface [polypeptide binding]; other site 298653007196 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 298653007197 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 298653007198 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653007199 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653007200 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 298653007201 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 298653007202 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 298653007203 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653007204 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653007205 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 298653007206 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 298653007207 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 298653007208 TM-ABC transporter signature motif; other site 298653007209 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 298653007210 TM-ABC transporter signature motif; other site 298653007211 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 298653007212 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 298653007213 Walker A/P-loop; other site 298653007214 ATP binding site [chemical binding]; other site 298653007215 Q-loop/lid; other site 298653007216 ABC transporter signature motif; other site 298653007217 Walker B; other site 298653007218 D-loop; other site 298653007219 H-loop/switch region; other site 298653007220 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 298653007221 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 298653007222 Walker A/P-loop; other site 298653007223 ATP binding site [chemical binding]; other site 298653007224 Q-loop/lid; other site 298653007225 ABC transporter signature motif; other site 298653007226 Walker B; other site 298653007227 D-loop; other site 298653007228 H-loop/switch region; other site 298653007229 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653007230 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 298653007231 putative ligand binding site [chemical binding]; other site 298653007232 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653007233 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 298653007234 putative ligand binding site [chemical binding]; other site 298653007235 Homeodomain-like domain; Region: HTH_23; pfam13384 298653007236 Winged helix-turn helix; Region: HTH_29; pfam13551 298653007237 Homeodomain-like domain; Region: HTH_32; pfam13565 298653007238 DDE superfamily endonuclease; Region: DDE_3; pfam13358 298653007239 Homeodomain-like domain; Region: HTH_23; pfam13384 298653007240 Winged helix-turn helix; Region: HTH_29; pfam13551 298653007241 Homeodomain-like domain; Region: HTH_32; pfam13565 298653007242 DDE superfamily endonuclease; Region: DDE_3; pfam13358 298653007243 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 298653007244 Transposase; Region: DEDD_Tnp_IS110; pfam01548 298653007245 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 298653007246 Homeodomain-like domain; Region: HTH_23; pfam13384 298653007247 Winged helix-turn helix; Region: HTH_29; pfam13551 298653007248 Homeodomain-like domain; Region: HTH_32; pfam13565 298653007249 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 298653007250 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 298653007251 putative active site [active] 298653007252 putative NTP binding site [chemical binding]; other site 298653007253 putative nucleic acid binding site [nucleotide binding]; other site 298653007254 Type II intron maturase; Region: Intron_maturas2; pfam01348 298653007255 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 298653007256 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 298653007257 DDE superfamily endonuclease; Region: DDE_4; pfam13359 298653007258 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 298653007259 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 298653007260 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 298653007261 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 298653007262 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 298653007263 NAD binding site [chemical binding]; other site 298653007264 catalytic residues [active] 298653007265 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 298653007266 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 298653007267 [2Fe-2S] cluster binding site [ion binding]; other site 298653007268 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 298653007269 alpha subunit interface [polypeptide binding]; other site 298653007270 active site 298653007271 substrate binding site [chemical binding]; other site 298653007272 Fe binding site [ion binding]; other site 298653007273 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 298653007274 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 298653007275 substrate binding pocket [chemical binding]; other site 298653007276 active site 298653007277 iron coordination sites [ion binding]; other site 298653007278 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653007279 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653007280 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 298653007281 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 298653007282 FAD binding pocket [chemical binding]; other site 298653007283 FAD binding motif [chemical binding]; other site 298653007284 phosphate binding motif [ion binding]; other site 298653007285 beta-alpha-beta structure motif; other site 298653007286 NAD(p) ribose binding residues [chemical binding]; other site 298653007287 NAD binding pocket [chemical binding]; other site 298653007288 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 298653007289 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 298653007290 catalytic loop [active] 298653007291 iron binding site [ion binding]; other site 298653007292 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653007293 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653007294 NAD(P) binding site [chemical binding]; other site 298653007295 active site 298653007296 Uncharacterized conserved protein [Function unknown]; Region: COG2128 298653007297 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 298653007298 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 298653007299 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 298653007300 [2Fe-2S] cluster binding site [ion binding]; other site 298653007301 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 298653007302 alpha subunit interface [polypeptide binding]; other site 298653007303 active site 298653007304 substrate binding site [chemical binding]; other site 298653007305 Fe binding site [ion binding]; other site 298653007306 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 298653007307 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 298653007308 active site 298653007309 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 298653007310 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 298653007311 FAD binding pocket [chemical binding]; other site 298653007312 FAD binding motif [chemical binding]; other site 298653007313 phosphate binding motif [ion binding]; other site 298653007314 beta-alpha-beta structure motif; other site 298653007315 NAD(p) ribose binding residues [chemical binding]; other site 298653007316 NAD binding pocket [chemical binding]; other site 298653007317 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 298653007318 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 298653007319 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 298653007320 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653007321 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653007322 AMP-binding domain protein; Validated; Region: PRK07529 298653007323 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653007324 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 298653007325 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653007326 FAD binding domain; Region: FAD_binding_3; pfam01494 298653007327 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653007328 Amidohydrolase; Region: Amidohydro_2; pfam04909 298653007329 AMP-binding domain protein; Validated; Region: PRK07529 298653007330 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 298653007331 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 298653007332 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653007333 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653007334 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 298653007335 Major Facilitator Superfamily; Region: MFS_1; pfam07690 298653007336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653007337 putative substrate translocation pore; other site 298653007338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653007339 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653007340 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653007341 classical (c) SDRs; Region: SDR_c; cd05233 298653007342 NAD(P) binding site [chemical binding]; other site 298653007343 active site 298653007344 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 298653007345 DDE superfamily endonuclease; Region: DDE_4; pfam13359 298653007346 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 298653007347 active site 298653007348 FMN binding site [chemical binding]; other site 298653007349 substrate binding site [chemical binding]; other site 298653007350 putative catalytic residue [active] 298653007351 Transposase; Region: DEDD_Tnp_IS110; pfam01548 298653007352 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 298653007353 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 298653007354 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 298653007355 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 298653007356 active site 298653007357 metal binding site [ion binding]; metal-binding site 298653007358 The C-terminal domain of 2,4,5-Trihydroxytoluene (THT) oxygenase, which is an extradiol dioxygenease in the 2,4-dinitrotoluene (DNT) degradation pathway; Region: THT_oxygenase_C; cd07257 298653007359 putative active site [active] 298653007360 putative metal binding site [ion binding]; other site 298653007361 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653007362 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 298653007363 putative ligand binding site [chemical binding]; other site 298653007364 Homeodomain-like domain; Region: HTH_23; pfam13384 298653007365 Winged helix-turn helix; Region: HTH_29; pfam13551 298653007366 Homeodomain-like domain; Region: HTH_32; pfam13565 298653007367 DDE superfamily endonuclease; Region: DDE_3; pfam13358 298653007368 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653007369 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653007370 active site 298653007371 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 298653007372 DDE superfamily endonuclease; Region: DDE_3; pfam13358 298653007373 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 298653007374 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 298653007375 Homeodomain-like domain; Region: HTH_32; pfam13565 298653007376 Winged helix-turn helix; Region: HTH_33; pfam13592 298653007377 Cupin domain; Region: Cupin_2; pfam07883 298653007378 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 298653007379 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653007380 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 298653007381 active site 298653007382 substrate binding site [chemical binding]; other site 298653007383 activation loop (A-loop); other site 298653007384 AAA ATPase domain; Region: AAA_16; pfam13191 298653007385 Predicted ATPase [General function prediction only]; Region: COG3899 298653007386 GAF domain; Region: GAF_3; pfam13492 298653007387 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653007388 metal binding site [ion binding]; metal-binding site 298653007389 active site 298653007390 I-site; other site 298653007391 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 298653007392 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 298653007393 NAD(P) binding site [chemical binding]; other site 298653007394 DDE superfamily endonuclease; Region: DDE_5; pfam13546 298653007395 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653007396 substrate binding site [chemical binding]; other site 298653007397 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 298653007398 oxyanion hole (OAH) forming residues; other site 298653007399 trimer interface [polypeptide binding]; other site 298653007400 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 298653007401 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 298653007402 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 298653007403 dimer interface [polypeptide binding]; other site 298653007404 active site 298653007405 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 298653007406 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653007407 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653007408 active site 298653007409 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 298653007410 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 298653007411 classical (c) SDRs; Region: SDR_c; cd05233 298653007412 NAD(P) binding site [chemical binding]; other site 298653007413 active site 298653007414 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 298653007415 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653007416 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653007417 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653007418 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 298653007419 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 298653007420 putative NTP binding site [chemical binding]; other site 298653007421 Transposase, Mutator family; Region: Transposase_mut; pfam00872 298653007422 MULE transposase domain; Region: MULE; pfam10551 298653007423 putative transposase OrfB; Reviewed; Region: PHA02517 298653007424 Integrase core domain; Region: rve; pfam00665 298653007425 Integrase core domain; Region: rve_3; pfam13683 298653007426 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 298653007427 ABC-2 type transporter; Region: ABC2_membrane; cl11417 298653007428 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 298653007429 Integrase core domain; Region: rve; pfam00665 298653007430 Integrase core domain; Region: rve_3; pfam13683 298653007431 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 298653007432 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 298653007433 Helix-turn-helix domain; Region: HTH_18; pfam12833 298653007434 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 298653007435 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 298653007436 FAD binding pocket [chemical binding]; other site 298653007437 FAD binding motif [chemical binding]; other site 298653007438 phosphate binding motif [ion binding]; other site 298653007439 NAD binding pocket [chemical binding]; other site 298653007440 O-methyltransferase; Region: Methyltransf_2; pfam00891 298653007441 Helix-turn-helix domains; Region: HTH; cl00088 298653007442 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 298653007443 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 298653007444 intersubunit interface [polypeptide binding]; other site 298653007445 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 298653007446 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 298653007447 ABC-ATPase subunit interface; other site 298653007448 dimer interface [polypeptide binding]; other site 298653007449 putative PBP binding regions; other site 298653007450 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 298653007451 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 298653007452 Walker A/P-loop; other site 298653007453 ATP binding site [chemical binding]; other site 298653007454 Q-loop/lid; other site 298653007455 ABC transporter signature motif; other site 298653007456 Walker B; other site 298653007457 D-loop; other site 298653007458 H-loop/switch region; other site 298653007459 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 298653007460 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 298653007461 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653007462 Walker A/P-loop; other site 298653007463 ATP binding site [chemical binding]; other site 298653007464 Q-loop/lid; other site 298653007465 ABC transporter signature motif; other site 298653007466 Walker B; other site 298653007467 D-loop; other site 298653007468 H-loop/switch region; other site 298653007469 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 298653007470 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 298653007471 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653007472 Walker A/P-loop; other site 298653007473 ATP binding site [chemical binding]; other site 298653007474 Q-loop/lid; other site 298653007475 ABC transporter signature motif; other site 298653007476 Walker B; other site 298653007477 D-loop; other site 298653007478 H-loop/switch region; other site 298653007479 Condensation domain; Region: Condensation; pfam00668 298653007480 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 298653007481 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 298653007482 AMP-binding enzyme; Region: AMP-binding; cl15778 298653007483 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 298653007484 Transposase domain (DUF772); Region: DUF772; pfam05598 298653007485 DDE superfamily endonuclease; Region: DDE_5; cl02413 298653007486 FAD binding domain; Region: FAD_binding_3; pfam01494 298653007487 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653007488 tricarballylate dehydrogenase; Validated; Region: PRK08274 298653007489 MgtE intracellular N domain; Region: MgtE_N; smart00924 298653007490 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 298653007491 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653007492 AMP-binding enzyme; Region: AMP-binding; cl15778 298653007493 dihydrodipicolinate reductase; Provisional; Region: PRK00048 298653007494 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 298653007495 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 298653007496 MbtH-like protein; Region: MbtH; pfam03621 298653007497 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 298653007498 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653007499 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 298653007500 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653007501 Phosphopantetheine attachment site; Region: PP-binding; cl09936 298653007502 Condensation domain; Region: Condensation; pfam00668 298653007503 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 298653007504 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 298653007505 AMP-binding enzyme; Region: AMP-binding; cl15778 298653007506 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 298653007507 Condensation domain; Region: Condensation; pfam00668 298653007508 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 298653007509 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 298653007510 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 298653007511 AMP-binding enzyme; Region: AMP-binding; cl15778 298653007512 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 298653007513 Condensation domain; Region: Condensation; pfam00668 298653007514 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 298653007515 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 298653007516 Condensation domain; Region: Condensation; pfam00668 298653007517 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 298653007518 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 298653007519 AMP-binding enzyme; Region: AMP-binding; cl15778 298653007520 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 298653007521 Condensation domain; Region: Condensation; pfam00668 298653007522 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 298653007523 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 298653007524 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 298653007525 AMP-binding enzyme; Region: AMP-binding; cl15778 298653007526 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 298653007527 Condensation domain; Region: Condensation; pfam00668 298653007528 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 298653007529 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 298653007530 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 298653007531 Transposase; Region: HTH_Tnp_Tc3_2; pfam01498 298653007532 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 298653007533 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 298653007534 putative active site [active] 298653007535 putative NTP binding site [chemical binding]; other site 298653007536 putative nucleic acid binding site [nucleotide binding]; other site 298653007537 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 298653007538 putative transposase OrfB; Reviewed; Region: PHA02517 298653007539 HTH-like domain; Region: HTH_21; pfam13276 298653007540 Integrase core domain; Region: rve; pfam00665 298653007541 Integrase core domain; Region: rve_3; pfam13683 298653007542 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 298653007543 Transposase; Region: HTH_Tnp_1; pfam01527 298653007544 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 298653007545 Homeodomain-like domain; Region: HTH_32; pfam13565 298653007546 Winged helix-turn helix; Region: HTH_33; pfam13592 298653007547 DDE superfamily endonuclease; Region: DDE_3; pfam13358 298653007548 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 298653007549 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 298653007550 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 298653007551 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 298653007552 NlpC/P60 family; Region: NLPC_P60; pfam00877 298653007553 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 298653007554 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 298653007555 catalytic residue [active] 298653007556 putative FPP diphosphate binding site; other site 298653007557 putative FPP binding hydrophobic cleft; other site 298653007558 dimer interface [polypeptide binding]; other site 298653007559 putative IPP diphosphate binding site; other site 298653007560 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 298653007561 NlpC/P60 family; Region: NLPC_P60; pfam00877 298653007562 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 298653007563 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653007564 non-specific DNA binding site [nucleotide binding]; other site 298653007565 salt bridge; other site 298653007566 sequence-specific DNA binding site [nucleotide binding]; other site 298653007567 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 298653007568 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 298653007569 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 298653007570 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 298653007571 S-adenosylmethionine binding site [chemical binding]; other site 298653007572 Integrase core domain; Region: rve; pfam00665 298653007573 Integrase core domain; Region: rve_3; pfam13683 298653007574 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 298653007575 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 298653007576 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 298653007577 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 298653007578 active site 298653007579 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 298653007580 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 298653007581 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 298653007582 NADP binding site [chemical binding]; other site 298653007583 active site 298653007584 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 298653007585 Thioesterase; Region: PKS_TE; smart00824 298653007586 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 298653007587 Transposase; Region: HTH_Tnp_1; pfam01527 298653007588 HTH-like domain; Region: HTH_21; pfam13276 298653007589 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 298653007590 Integrase core domain; Region: rve; pfam00665 298653007591 Integrase core domain; Region: rve_3; pfam13683 298653007592 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 298653007593 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653007594 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653007595 active site 298653007596 FOG: CBS domain [General function prediction only]; Region: COG0517 298653007597 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 298653007598 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 298653007599 Integrase core domain; Region: rve_3; cl15866 298653007600 Transposase; Region: DEDD_Tnp_IS110; pfam01548 298653007601 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 298653007602 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 298653007603 FOG: WD40 repeat [General function prediction only]; Region: COG2319 298653007604 WD domain, G-beta repeat; Region: WD40; pfam00400 298653007605 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 298653007606 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 298653007607 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 298653007608 FeS/SAM binding site; other site 298653007609 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 298653007610 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 298653007611 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 298653007612 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 298653007613 NADP binding site [chemical binding]; other site 298653007614 homodimer interface [polypeptide binding]; other site 298653007615 active site 298653007616 substrate binding site [chemical binding]; other site 298653007617 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 298653007618 MarR family; Region: MarR; pfam01047 298653007619 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 298653007620 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 298653007621 DDE superfamily endonuclease; Region: DDE_4; pfam13359 298653007622 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 298653007623 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 298653007624 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653007625 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 298653007626 putative ligand binding site [chemical binding]; other site 298653007627 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 298653007628 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 298653007629 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 298653007630 PYR/PP interface [polypeptide binding]; other site 298653007631 dimer interface [polypeptide binding]; other site 298653007632 TPP binding site [chemical binding]; other site 298653007633 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 298653007634 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 298653007635 TPP-binding site; other site 298653007636 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 298653007637 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 298653007638 tetrameric interface [polypeptide binding]; other site 298653007639 NAD binding site [chemical binding]; other site 298653007640 catalytic residues [active] 298653007641 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 298653007642 NMT1/THI5 like; Region: NMT1; pfam09084 298653007643 NMT1-like family; Region: NMT1_2; cl15260 298653007644 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 298653007645 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 298653007646 dimer interface [polypeptide binding]; other site 298653007647 NADP binding site [chemical binding]; other site 298653007648 catalytic residues [active] 298653007649 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 298653007650 Transcriptional regulator [Transcription]; Region: IclR; COG1414 298653007651 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 298653007652 Bacterial transcriptional regulator; Region: IclR; pfam01614 298653007653 SnoaL-like domain; Region: SnoaL_2; pfam12680 298653007654 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 298653007655 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 298653007656 Walker A/P-loop; other site 298653007657 ATP binding site [chemical binding]; other site 298653007658 Q-loop/lid; other site 298653007659 ABC transporter signature motif; other site 298653007660 Walker B; other site 298653007661 D-loop; other site 298653007662 H-loop/switch region; other site 298653007663 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 298653007664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653007665 dimer interface [polypeptide binding]; other site 298653007666 conserved gate region; other site 298653007667 putative PBP binding loops; other site 298653007668 ABC-ATPase subunit interface; other site 298653007669 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 298653007670 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 298653007671 dihydroorotase; Provisional; Region: PRK09237 298653007672 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 298653007673 active site 298653007674 enoyl-CoA hydratase; Validated; Region: PRK08139 298653007675 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653007676 substrate binding site [chemical binding]; other site 298653007677 oxyanion hole (OAH) forming residues; other site 298653007678 trimer interface [polypeptide binding]; other site 298653007679 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 298653007680 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 298653007681 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 298653007682 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653007683 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653007684 enoyl-CoA hydratase; Provisional; Region: PRK07827 298653007685 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653007686 substrate binding site [chemical binding]; other site 298653007687 oxyanion hole (OAH) forming residues; other site 298653007688 trimer interface [polypeptide binding]; other site 298653007689 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653007690 metal binding site [ion binding]; metal-binding site 298653007691 active site 298653007692 I-site; other site 298653007693 DDE superfamily endonuclease; Region: DDE_5; pfam13546 298653007694 Predicted transcriptional regulators [Transcription]; Region: COG1695 298653007695 AMP-binding domain protein; Validated; Region: PRK08315 298653007696 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653007697 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653007698 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653007699 active site 298653007700 TIGR03084 family protein; Region: TIGR03084 298653007701 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 298653007702 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 298653007703 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653007704 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 298653007705 DDE superfamily endonuclease; Region: DDE_5; cl02413 298653007706 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653007707 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 298653007708 ligand binding site [chemical binding]; other site 298653007709 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 298653007710 TM-ABC transporter signature motif; other site 298653007711 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 298653007712 TM-ABC transporter signature motif; other site 298653007713 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 298653007714 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 298653007715 Walker A/P-loop; other site 298653007716 ATP binding site [chemical binding]; other site 298653007717 Q-loop/lid; other site 298653007718 ABC transporter signature motif; other site 298653007719 Walker B; other site 298653007720 D-loop; other site 298653007721 H-loop/switch region; other site 298653007722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653007723 Major Facilitator Superfamily; Region: MFS_1; pfam07690 298653007724 putative substrate translocation pore; other site 298653007725 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 298653007726 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 298653007727 Walker A/P-loop; other site 298653007728 ATP binding site [chemical binding]; other site 298653007729 Q-loop/lid; other site 298653007730 ABC transporter signature motif; other site 298653007731 Walker B; other site 298653007732 D-loop; other site 298653007733 H-loop/switch region; other site 298653007734 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653007735 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 298653007736 substrate binding pocket [chemical binding]; other site 298653007737 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 298653007738 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 298653007739 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 298653007740 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 298653007741 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 298653007742 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 298653007743 Amidase; Region: Amidase; cl11426 298653007744 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 298653007745 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 298653007746 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 298653007747 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 298653007748 DDE domain; Region: DDE_Tnp_IS240; pfam13610 298653007749 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 298653007750 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 298653007751 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653007752 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653007753 Sulfatase; Region: Sulfatase; cl10460 298653007754 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 298653007755 DDE superfamily endonuclease; Region: DDE_3; pfam13358 298653007756 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 298653007757 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 298653007758 Homeodomain-like domain; Region: HTH_32; pfam13565 298653007759 Winged helix-turn helix; Region: HTH_33; pfam13592 298653007760 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653007761 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 298653007762 putative ligand binding site [chemical binding]; other site 298653007763 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 298653007764 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653007765 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 298653007766 Amidase; Region: Amidase; cl11426 298653007767 Amidase; Region: Amidase; cl11426 298653007768 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 298653007769 classical (c) SDRs; Region: SDR_c; cd05233 298653007770 NAD(P) binding site [chemical binding]; other site 298653007771 active site 298653007772 DDE superfamily endonuclease; Region: DDE_5; cl02413 298653007773 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 298653007774 FHA domain; Region: FHA; pfam00498 298653007775 phosphopeptide binding site; other site 298653007776 ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR). DR is a well-described phenomenon occurring in fungi and shares several similarities with processes...; Region: ABCG_EPDR; cd03213 298653007777 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 298653007778 Walker A/P-loop; other site 298653007779 ATP binding site [chemical binding]; other site 298653007780 Q-loop/lid; other site 298653007781 ABC transporter signature motif; other site 298653007782 Walker B; other site 298653007783 D-loop; other site 298653007784 H-loop/switch region; other site 298653007785 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 298653007786 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 298653007787 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 298653007788 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 298653007789 Walker A/P-loop; other site 298653007790 ATP binding site [chemical binding]; other site 298653007791 Q-loop/lid; other site 298653007792 ABC transporter signature motif; other site 298653007793 Walker B; other site 298653007794 D-loop; other site 298653007795 H-loop/switch region; other site 298653007796 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 298653007797 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 298653007798 Histidine kinase; Region: HisKA_3; pfam07730 298653007799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653007800 ATP binding site [chemical binding]; other site 298653007801 Mg2+ binding site [ion binding]; other site 298653007802 G-X-G motif; other site 298653007803 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653007804 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653007805 active site 298653007806 phosphorylation site [posttranslational modification] 298653007807 intermolecular recognition site; other site 298653007808 dimerization interface [polypeptide binding]; other site 298653007809 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653007810 DNA binding residues [nucleotide binding] 298653007811 dimerization interface [polypeptide binding]; other site 298653007812 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 298653007813 Winged helix-turn helix; Region: HTH_29; pfam13551 298653007814 DDE superfamily endonuclease; Region: DDE_3; pfam13358 298653007815 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 298653007816 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 298653007817 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 298653007818 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 298653007819 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 298653007820 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 298653007821 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 298653007822 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 298653007823 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653007824 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 298653007825 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 298653007826 TM-ABC transporter signature motif; other site 298653007827 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 298653007828 TM-ABC transporter signature motif; other site 298653007829 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 298653007830 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 298653007831 Walker A/P-loop; other site 298653007832 ATP binding site [chemical binding]; other site 298653007833 Q-loop/lid; other site 298653007834 ABC transporter signature motif; other site 298653007835 Walker B; other site 298653007836 D-loop; other site 298653007837 H-loop/switch region; other site 298653007838 D-galactonate transporter; Region: 2A0114; TIGR00893 298653007839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653007840 putative substrate translocation pore; other site 298653007841 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 298653007842 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 298653007843 Walker A/P-loop; other site 298653007844 ATP binding site [chemical binding]; other site 298653007845 Q-loop/lid; other site 298653007846 ABC transporter signature motif; other site 298653007847 Walker B; other site 298653007848 D-loop; other site 298653007849 H-loop/switch region; other site 298653007850 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 298653007851 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 298653007852 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 298653007853 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 298653007854 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 298653007855 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 298653007856 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 298653007857 Transcriptional regulators [Transcription]; Region: PurR; COG1609 298653007858 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 298653007859 DNA binding site [nucleotide binding] 298653007860 domain linker motif; other site 298653007861 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 298653007862 beta-D-glucuronidase; Provisional; Region: PRK10150 298653007863 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 298653007864 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 298653007865 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 298653007866 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 298653007867 glucuronate isomerase; Reviewed; Region: PRK02925 298653007868 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 298653007869 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 298653007870 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 298653007871 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 298653007872 MoaE homodimer interface [polypeptide binding]; other site 298653007873 MoaD interaction [polypeptide binding]; other site 298653007874 active site residues [active] 298653007875 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 298653007876 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 298653007877 FeS/SAM binding site; other site 298653007878 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 298653007879 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 298653007880 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653007881 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653007882 classical (c) SDRs; Region: SDR_c; cd05233 298653007883 active site 298653007884 creatinine amidohydrolase family protein, mycofactocin system; Region: actino_creatin; TIGR03964 298653007885 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 298653007886 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 298653007887 phosphate binding site [ion binding]; other site 298653007888 mycofactocin radical SAM maturase; Region: rSAM_MSMEG_1423; TIGR03962 298653007889 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 298653007890 FeS/SAM binding site; other site 298653007891 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 298653007892 mycofactocin system RPExFGAL protein; Region: Ac_RPExFGAL; TIGR03967 298653007893 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 298653007894 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 298653007895 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 298653007896 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 298653007897 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 298653007898 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 298653007899 putative hydrophobic ligand binding site [chemical binding]; other site 298653007900 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 298653007901 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 298653007902 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 298653007903 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 298653007904 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 298653007905 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 298653007906 XdhC Rossmann domain; Region: XdhC_C; pfam13478 298653007907 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 298653007908 dimer interface [polypeptide binding]; other site 298653007909 substrate binding site [chemical binding]; other site 298653007910 metal binding site [ion binding]; metal-binding site 298653007911 Uncharacterized conserved protein [Function unknown]; Region: COG2128 298653007912 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 298653007913 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653007914 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653007915 NAD(P) binding site [chemical binding]; other site 298653007916 active site 298653007917 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653007918 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 298653007919 putative ligand binding site [chemical binding]; other site 298653007920 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653007921 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653007922 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 298653007923 classical (c) SDRs; Region: SDR_c; cd05233 298653007924 NAD(P) binding site [chemical binding]; other site 298653007925 active site 298653007926 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653007927 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 298653007928 putative ligand binding site [chemical binding]; other site 298653007929 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653007930 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 298653007931 putative ligand binding site [chemical binding]; other site 298653007932 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 298653007933 TM-ABC transporter signature motif; other site 298653007934 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 298653007935 TM-ABC transporter signature motif; other site 298653007936 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 298653007937 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 298653007938 Walker A/P-loop; other site 298653007939 ATP binding site [chemical binding]; other site 298653007940 Q-loop/lid; other site 298653007941 ABC transporter signature motif; other site 298653007942 Walker B; other site 298653007943 D-loop; other site 298653007944 H-loop/switch region; other site 298653007945 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 298653007946 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 298653007947 Walker A/P-loop; other site 298653007948 ATP binding site [chemical binding]; other site 298653007949 Q-loop/lid; other site 298653007950 ABC transporter signature motif; other site 298653007951 Walker B; other site 298653007952 D-loop; other site 298653007953 H-loop/switch region; other site 298653007954 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653007955 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 298653007956 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 298653007957 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 298653007958 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 298653007959 Transcriptional regulators [Transcription]; Region: PurR; COG1609 298653007960 Periplasmic binding protein-like domain; Region: Peripla_BP_3; pfam13377 298653007961 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 298653007962 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 298653007963 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 298653007964 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653007965 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 298653007966 putative ligand binding site [chemical binding]; other site 298653007967 Predicted acyl esterases [General function prediction only]; Region: COG2936 298653007968 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 298653007969 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 298653007970 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653007971 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653007972 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653007973 NAD(P) binding site [chemical binding]; other site 298653007974 active site 298653007975 enoyl-CoA hydratase; Provisional; Region: PRK06190 298653007976 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653007977 substrate binding site [chemical binding]; other site 298653007978 oxyanion hole (OAH) forming residues; other site 298653007979 trimer interface [polypeptide binding]; other site 298653007980 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 298653007981 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653007982 Domain of unknown function (DUF4009); Region: DUF4009; pfam13193 298653007983 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 298653007984 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 298653007985 NAD(P) binding site [chemical binding]; other site 298653007986 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 298653007987 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 298653007988 active site 298653007989 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653007990 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 298653007991 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653007992 Helix-turn-helix domains; Region: HTH; cl00088 298653007993 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653007994 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653007995 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 298653007996 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 298653007997 classical (c) SDRs; Region: SDR_c; cd05233 298653007998 NAD(P) binding site [chemical binding]; other site 298653007999 active site 298653008000 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 298653008001 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653008002 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653008003 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 298653008004 putative ligand binding site [chemical binding]; other site 298653008005 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 298653008006 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653008007 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 298653008008 TM-ABC transporter signature motif; other site 298653008009 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 298653008010 TM-ABC transporter signature motif; other site 298653008011 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 298653008012 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 298653008013 Walker A/P-loop; other site 298653008014 ATP binding site [chemical binding]; other site 298653008015 Q-loop/lid; other site 298653008016 ABC transporter signature motif; other site 298653008017 Walker B; other site 298653008018 D-loop; other site 298653008019 H-loop/switch region; other site 298653008020 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653008021 Major Facilitator Superfamily; Region: MFS_1; pfam07690 298653008022 putative substrate translocation pore; other site 298653008023 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 298653008024 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 298653008025 Walker A/P-loop; other site 298653008026 ATP binding site [chemical binding]; other site 298653008027 Q-loop/lid; other site 298653008028 ABC transporter signature motif; other site 298653008029 Walker B; other site 298653008030 D-loop; other site 298653008031 H-loop/switch region; other site 298653008032 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 298653008033 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 298653008034 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 298653008035 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 298653008036 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 298653008037 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 298653008038 Walker A/P-loop; other site 298653008039 ATP binding site [chemical binding]; other site 298653008040 Q-loop/lid; other site 298653008041 ABC transporter signature motif; other site 298653008042 Walker B; other site 298653008043 D-loop; other site 298653008044 H-loop/switch region; other site 298653008045 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 298653008046 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 298653008047 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653008048 Walker A/P-loop; other site 298653008049 ATP binding site [chemical binding]; other site 298653008050 Q-loop/lid; other site 298653008051 ABC transporter signature motif; other site 298653008052 Walker B; other site 298653008053 D-loop; other site 298653008054 H-loop/switch region; other site 298653008055 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 298653008056 dimerization interface [polypeptide binding]; other site 298653008057 putative DNA binding site [nucleotide binding]; other site 298653008058 Transcriptional regulators [Transcription]; Region: MarR; COG1846 298653008059 putative Zn2+ binding site [ion binding]; other site 298653008060 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 298653008061 beta-D-glucuronidase; Provisional; Region: PRK10150 298653008062 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 298653008063 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 298653008064 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 298653008065 Transcriptional regulators [Transcription]; Region: PurR; COG1609 298653008066 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 298653008067 DNA binding site [nucleotide binding] 298653008068 domain linker motif; other site 298653008069 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 298653008070 dimerization interface [polypeptide binding]; other site 298653008071 ligand binding site [chemical binding]; other site 298653008072 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 298653008073 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 298653008074 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 298653008075 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 298653008076 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 298653008077 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 298653008078 classical (c) SDRs; Region: SDR_c; cd05233 298653008079 NAD(P) binding site [chemical binding]; other site 298653008080 active site 298653008081 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 298653008082 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653008083 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 298653008084 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 298653008085 Helix-turn-helix domains; Region: HTH; cl00088 298653008086 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 298653008087 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 298653008088 Integrase core domain; Region: rve; pfam00665 298653008089 Integrase core domain; Region: rve_3; pfam13683 298653008090 Tannase and feruloyl esterase; Region: Tannase; pfam07519 298653008091 Integrase core domain; Region: rve; pfam00665 298653008092 DDE domain; Region: DDE_Tnp_IS240; pfam13610 298653008093 MMPL family; Region: MMPL; pfam03176 298653008094 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 298653008095 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653008096 metal binding site [ion binding]; metal-binding site 298653008097 active site 298653008098 I-site; other site 298653008099 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653008100 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 298653008101 putative ligand binding site [chemical binding]; other site 298653008102 DDE superfamily endonuclease; Region: DDE_5; pfam13546 298653008103 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 298653008104 classical (c) SDRs; Region: SDR_c; cd05233 298653008105 NAD(P) binding site [chemical binding]; other site 298653008106 active site 298653008107 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 298653008108 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 298653008109 [2Fe-2S] cluster binding site [ion binding]; other site 298653008110 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 298653008111 alpha subunit interface [polypeptide binding]; other site 298653008112 active site 298653008113 substrate binding site [chemical binding]; other site 298653008114 Fe binding site [ion binding]; other site 298653008115 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 298653008116 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653008117 NAD(P) binding site [chemical binding]; other site 298653008118 active site 298653008119 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653008120 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653008121 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 298653008122 Histidine kinase; Region: HisKA_3; pfam07730 298653008123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653008124 ATP binding site [chemical binding]; other site 298653008125 Mg2+ binding site [ion binding]; other site 298653008126 short chain dehydrogenase; Provisional; Region: PRK07774 298653008127 classical (c) SDRs; Region: SDR_c; cd05233 298653008128 NAD(P) binding site [chemical binding]; other site 298653008129 active site 298653008130 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 298653008131 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 298653008132 NAD(P) binding site [chemical binding]; other site 298653008133 catalytic residues [active] 298653008134 short chain dehydrogenase; Provisional; Region: PRK05650 298653008135 classical (c) SDRs; Region: SDR_c; cd05233 298653008136 NAD(P) binding site [chemical binding]; other site 298653008137 active site 298653008138 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653008139 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 298653008140 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 298653008141 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653008142 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 298653008143 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653008144 classical (c) SDRs; Region: SDR_c; cd05233 298653008145 NAD(P) binding site [chemical binding]; other site 298653008146 active site 298653008147 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 298653008148 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 298653008149 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 298653008150 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 298653008151 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 298653008152 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653008153 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 298653008154 classical (c) SDRs; Region: SDR_c; cd05233 298653008155 NAD(P) binding site [chemical binding]; other site 298653008156 active site 298653008157 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 298653008158 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653008159 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 298653008160 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 298653008161 NAD(P) binding site [chemical binding]; other site 298653008162 catalytic residues [active] 298653008163 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 298653008164 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653008165 SnoaL-like domain; Region: SnoaL_4; pfam13577 298653008166 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 298653008167 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 298653008168 N- and C-terminal domain interface [polypeptide binding]; other site 298653008169 active site 298653008170 catalytic site [active] 298653008171 metal binding site [ion binding]; metal-binding site 298653008172 carbohydrate binding site [chemical binding]; other site 298653008173 ATP binding site [chemical binding]; other site 298653008174 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 298653008175 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 298653008176 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653008177 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653008178 NAD(P) binding site [chemical binding]; other site 298653008179 active site 298653008180 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 298653008181 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 298653008182 [2Fe-2S] cluster binding site [ion binding]; other site 298653008183 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 298653008184 alpha subunit interface [polypeptide binding]; other site 298653008185 active site 298653008186 substrate binding site [chemical binding]; other site 298653008187 Fe binding site [ion binding]; other site 298653008188 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 298653008189 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 298653008190 active site 298653008191 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 298653008192 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 298653008193 lipid-transfer protein; Provisional; Region: PRK07855 298653008194 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 298653008195 active site 298653008196 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 298653008197 DUF35 OB-fold domain; Region: DUF35; pfam01796 298653008198 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653008199 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653008200 Amidohydrolase; Region: Amidohydro_2; pfam04909 298653008201 Cupin domain; Region: Cupin_2; cl09118 298653008202 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 298653008203 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 298653008204 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 298653008205 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 298653008206 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 298653008207 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 298653008208 tetramer interface [polypeptide binding]; other site 298653008209 TPP-binding site [chemical binding]; other site 298653008210 heterodimer interface [polypeptide binding]; other site 298653008211 phosphorylation loop region [posttranslational modification] 298653008212 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 298653008213 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 298653008214 alpha subunit interface [polypeptide binding]; other site 298653008215 TPP binding site [chemical binding]; other site 298653008216 heterodimer interface [polypeptide binding]; other site 298653008217 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 298653008218 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 298653008219 lipoyl-biotinyl attachment site [posttranslational modification]; other site 298653008220 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 298653008221 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 298653008222 [2Fe-2S] cluster binding site [ion binding]; other site 298653008223 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 298653008224 putative alpha subunit interface [polypeptide binding]; other site 298653008225 putative active site [active] 298653008226 putative substrate binding site [chemical binding]; other site 298653008227 Fe binding site [ion binding]; other site 298653008228 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 298653008229 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 298653008230 catalytic loop [active] 298653008231 iron binding site [ion binding]; other site 298653008232 Amidohydrolase; Region: Amidohydro_2; pfam04909 298653008233 lipoyl synthase; Provisional; Region: PRK05481 298653008234 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 298653008235 FeS/SAM binding site; other site 298653008236 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 298653008237 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 298653008238 active site 298653008239 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653008240 classical (c) SDRs; Region: SDR_c; cd05233 298653008241 NAD(P) binding site [chemical binding]; other site 298653008242 active site 298653008243 mycofactocin radical SAM maturase; Region: rSAM_MSMEG_1423; TIGR03962 298653008244 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 298653008245 FeS/SAM binding site; other site 298653008246 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 298653008247 mycofactocin system RPExFGAL protein; Region: Ac_RPExFGAL; TIGR03967 298653008248 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 298653008249 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653008250 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653008251 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653008252 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653008253 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653008254 Amidohydrolase; Region: Amidohydro_2; pfam04909 298653008255 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 298653008256 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 298653008257 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653008258 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 298653008259 Helix-turn-helix domains; Region: HTH; cl00088 298653008260 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 298653008261 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 298653008262 active site 298653008263 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 298653008264 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 298653008265 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 298653008266 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653008267 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 298653008268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653008269 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 298653008270 putative substrate translocation pore; other site 298653008271 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653008272 NAD(P) binding site [chemical binding]; other site 298653008273 active site 298653008274 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 298653008275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653008276 putative substrate translocation pore; other site 298653008277 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 298653008278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 298653008279 SPFH domain / Band 7 family; Region: Band_7; pfam01145 298653008280 TIR domain; Region: TIR_2; pfam13676 298653008281 GUN4-like; Region: GUN4; pfam05419 298653008282 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 298653008283 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653008284 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 298653008285 CoenzymeA binding site [chemical binding]; other site 298653008286 subunit interaction site [polypeptide binding]; other site 298653008287 PHB binding site; other site 298653008288 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 298653008289 Part of AAA domain; Region: AAA_19; pfam13245 298653008290 Family description; Region: UvrD_C_2; cl15862 298653008291 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 298653008292 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 298653008293 ring oligomerisation interface [polypeptide binding]; other site 298653008294 ATP/Mg binding site [chemical binding]; other site 298653008295 stacking interactions; other site 298653008296 hinge regions; other site 298653008297 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 298653008298 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 298653008299 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 298653008300 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653008301 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653008302 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 298653008303 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 298653008304 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 298653008305 active site 298653008306 phosphorylation site [posttranslational modification] 298653008307 intermolecular recognition site; other site 298653008308 dimerization interface [polypeptide binding]; other site 298653008309 HTH domain; Region: HTH_11; pfam08279 298653008310 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 298653008311 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 298653008312 active site 298653008313 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 298653008314 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 298653008315 active site 298653008316 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 298653008317 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 298653008318 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 298653008319 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653008320 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 298653008321 Enoylreductase; Region: PKS_ER; smart00829 298653008322 NAD(P) binding site [chemical binding]; other site 298653008323 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 298653008324 putative NADP binding site [chemical binding]; other site 298653008325 active site 298653008326 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 298653008327 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 298653008328 putative homodimer interface [polypeptide binding]; other site 298653008329 putative homotetramer interface [polypeptide binding]; other site 298653008330 putative allosteric switch controlling residues; other site 298653008331 putative metal binding site [ion binding]; other site 298653008332 putative homodimer-homodimer interface [polypeptide binding]; other site 298653008333 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 298653008334 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 298653008335 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 298653008336 active site residue [active] 298653008337 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 298653008338 active site residue [active] 298653008339 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 298653008340 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 298653008341 active site 298653008342 Zn binding site [ion binding]; other site 298653008343 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 298653008344 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653008345 NAD(P) binding site [chemical binding]; other site 298653008346 active site 298653008347 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653008348 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 298653008349 putative ligand binding site [chemical binding]; other site 298653008350 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 298653008351 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 298653008352 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 298653008353 active site 298653008354 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 298653008355 alpha subunit interface [polypeptide binding]; other site 298653008356 active site 298653008357 substrate binding site [chemical binding]; other site 298653008358 Fe binding site [ion binding]; other site 298653008359 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653008360 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653008361 NAD(P) binding site [chemical binding]; other site 298653008362 active site 298653008363 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 298653008364 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 298653008365 FAD binding pocket [chemical binding]; other site 298653008366 FAD binding motif [chemical binding]; other site 298653008367 phosphate binding motif [ion binding]; other site 298653008368 beta-alpha-beta structure motif; other site 298653008369 NAD(p) ribose binding residues [chemical binding]; other site 298653008370 NAD binding pocket [chemical binding]; other site 298653008371 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 298653008372 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 298653008373 catalytic loop [active] 298653008374 iron binding site [ion binding]; other site 298653008375 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653008376 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653008377 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 298653008378 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 298653008379 substrate binding pocket [chemical binding]; other site 298653008380 active site 298653008381 iron coordination sites [ion binding]; other site 298653008382 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 298653008383 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 298653008384 [2Fe-2S] cluster binding site [ion binding]; other site 298653008385 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 298653008386 alpha subunit interface [polypeptide binding]; other site 298653008387 active site 298653008388 substrate binding site [chemical binding]; other site 298653008389 Fe binding site [ion binding]; other site 298653008390 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 298653008391 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 298653008392 NAD binding site [chemical binding]; other site 298653008393 catalytic residues [active] 298653008394 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 298653008395 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 298653008396 active site 298653008397 catalytic tetrad [active] 298653008398 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 298653008399 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653008400 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 298653008401 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 298653008402 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 298653008403 dimerization interface [polypeptide binding]; other site 298653008404 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 298653008405 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653008406 NAD(P) binding site [chemical binding]; other site 298653008407 active site 298653008408 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653008409 classical (c) SDRs; Region: SDR_c; cd05233 298653008410 NAD(P) binding site [chemical binding]; other site 298653008411 active site 298653008412 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653008413 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653008414 heat shock protein 90; Provisional; Region: PRK05218 298653008415 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653008416 ATP binding site [chemical binding]; other site 298653008417 Mg2+ binding site [ion binding]; other site 298653008418 G-X-G motif; other site 298653008419 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 298653008420 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 298653008421 DUF35 OB-fold domain; Region: DUF35; pfam01796 298653008422 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 298653008423 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 298653008424 active site 298653008425 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653008426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653008427 active site 298653008428 phosphorylation site [posttranslational modification] 298653008429 intermolecular recognition site; other site 298653008430 dimerization interface [polypeptide binding]; other site 298653008431 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653008432 DNA binding residues [nucleotide binding] 298653008433 dimerization interface [polypeptide binding]; other site 298653008434 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 298653008435 Histidine kinase; Region: HisKA_3; pfam07730 298653008436 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653008437 ATP binding site [chemical binding]; other site 298653008438 Mg2+ binding site [ion binding]; other site 298653008439 G-X-G motif; other site 298653008440 MMPL family; Region: MMPL; pfam03176 298653008441 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 298653008442 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 298653008443 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653008444 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 298653008445 putative ligand binding site [chemical binding]; other site 298653008446 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 298653008447 TM-ABC transporter signature motif; other site 298653008448 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 298653008449 TM-ABC transporter signature motif; other site 298653008450 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 298653008451 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 298653008452 Walker A/P-loop; other site 298653008453 ATP binding site [chemical binding]; other site 298653008454 Q-loop/lid; other site 298653008455 ABC transporter signature motif; other site 298653008456 Walker B; other site 298653008457 D-loop; other site 298653008458 H-loop/switch region; other site 298653008459 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 298653008460 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 298653008461 Walker A/P-loop; other site 298653008462 ATP binding site [chemical binding]; other site 298653008463 Q-loop/lid; other site 298653008464 ABC transporter signature motif; other site 298653008465 Walker B; other site 298653008466 D-loop; other site 298653008467 H-loop/switch region; other site 298653008468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653008469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653008470 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 298653008471 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 298653008472 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 298653008473 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653008474 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 298653008475 dimerization interface [polypeptide binding]; other site 298653008476 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 298653008477 ATP binding site [chemical binding]; other site 298653008478 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 298653008479 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 298653008480 HupF/HypC family; Region: HupF_HypC; pfam01455 298653008481 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 298653008482 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 298653008483 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 298653008484 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 298653008485 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 298653008486 putative substrate-binding site; other site 298653008487 nickel binding site [ion binding]; other site 298653008488 DDE domain; Region: DDE_Tnp_IS240; pfam13610 298653008489 Integrase core domain; Region: rve; pfam00665 298653008490 putative transposase OrfB; Reviewed; Region: PHA02517 298653008491 Integrase core domain; Region: rve; pfam00665 298653008492 Integrase core domain; Region: rve_3; pfam13683 298653008493 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 298653008494 Transposase; Region: DDE_Tnp_ISL3; pfam01610 298653008495 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 298653008496 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 298653008497 putative active site [active] 298653008498 putative NTP binding site [chemical binding]; other site 298653008499 putative nucleic acid binding site [nucleotide binding]; other site 298653008500 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 298653008501 Integrase core domain; Region: rve; pfam00665 298653008502 Integrase core domain; Region: rve_3; pfam13683 298653008503 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 298653008504 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 298653008505 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 298653008506 DDE superfamily endonuclease; Region: DDE_4; pfam13359 298653008507 Winged helix-turn helix; Region: HTH_29; pfam13551 298653008508 Homeodomain-like domain; Region: HTH_32; pfam13565 298653008509 Integrase core domain; Region: rve; cl01316 298653008510 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 298653008511 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 298653008512 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653008513 AMP-binding enzyme; Region: AMP-binding; cl15778 298653008514 Winged helix-turn helix; Region: HTH_29; pfam13551 298653008515 Helix-turn-helix domain; Region: HTH_28; pfam13518 298653008516 Homeodomain-like domain; Region: HTH_32; pfam13565 298653008517 DDE superfamily endonuclease; Region: DDE_3; pfam13358 298653008518 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 298653008519 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 298653008520 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 298653008521 Putative amidase domain; Region: Amidase_6; pfam12671 298653008522 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 298653008523 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 298653008524 Winged helix-turn helix; Region: HTH_29; pfam13551 298653008525 Transposase; Region: HTH_Tnp_Tc3_2; pfam01498 298653008526 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 298653008527 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 298653008528 putative substrate binding pocket [chemical binding]; other site 298653008529 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 298653008530 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 298653008531 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 298653008532 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 298653008533 AB domain interface; other site 298653008534 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 298653008535 AC domain interface; other site 298653008536 putative substrate binding pocket [chemical binding]; other site 298653008537 catalytic triad [active] 298653008538 interchain disulfide; other site 298653008539 TIR domain; Region: TIR_2; pfam13676 298653008540 NB-ARC domain; Region: NB-ARC; pfam00931 298653008541 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 298653008542 TPR motif; other site 298653008543 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653008544 binding surface 298653008545 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653008546 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 298653008547 binding surface 298653008548 TPR motif; other site 298653008549 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653008550 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cd00397 298653008551 active site 298653008552 DNA binding site [nucleotide binding] 298653008553 Int/Topo IB signature motif; other site 298653008554 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 298653008555 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 298653008556 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 298653008557 HSP70 interaction site [polypeptide binding]; other site 298653008558 Domain of unknown function (DUF222); Region: DUF222; pfam02720 298653008559 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 298653008560 active site 298653008561 Uncharacterized conserved protein [Function unknown]; Region: COG5361 298653008562 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 298653008563 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 298653008564 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653008565 active site 298653008566 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 298653008567 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653008568 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 298653008569 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 298653008570 Acyltransferase family; Region: Acyl_transf_3; pfam01757 298653008571 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 298653008572 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 298653008573 Walker A/P-loop; other site 298653008574 ATP binding site [chemical binding]; other site 298653008575 Q-loop/lid; other site 298653008576 ABC transporter signature motif; other site 298653008577 Walker B; other site 298653008578 D-loop; other site 298653008579 H-loop/switch region; other site 298653008580 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 298653008581 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 298653008582 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 298653008583 Walker A/P-loop; other site 298653008584 ATP binding site [chemical binding]; other site 298653008585 Q-loop/lid; other site 298653008586 ABC transporter signature motif; other site 298653008587 Walker B; other site 298653008588 D-loop; other site 298653008589 H-loop/switch region; other site 298653008590 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 298653008591 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 298653008592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653008593 putative PBP binding loops; other site 298653008594 dimer interface [polypeptide binding]; other site 298653008595 ABC-ATPase subunit interface; other site 298653008596 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 298653008597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653008598 ABC-ATPase subunit interface; other site 298653008599 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 298653008600 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 298653008601 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653008602 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 298653008603 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653008604 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653008605 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 298653008606 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653008607 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 298653008608 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653008609 Erythronolide synthase docking; Region: Docking; pfam08990 298653008610 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 298653008611 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 298653008612 active site 298653008613 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 298653008614 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 298653008615 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 298653008616 Erythronolide synthase docking; Region: Docking; pfam08990 298653008617 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 298653008618 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 298653008619 active site 298653008620 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 298653008621 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 298653008622 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 298653008623 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 298653008624 putative NADP binding site [chemical binding]; other site 298653008625 active site 298653008626 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 298653008627 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 298653008628 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 298653008629 active site 298653008630 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 298653008631 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 298653008632 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 298653008633 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653008634 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 298653008635 Enoylreductase; Region: PKS_ER; smart00829 298653008636 NAD(P) binding site [chemical binding]; other site 298653008637 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 298653008638 putative NADP binding site [chemical binding]; other site 298653008639 active site 298653008640 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 298653008641 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 298653008642 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 298653008643 active site 298653008644 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 298653008645 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 298653008646 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 298653008647 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 298653008648 active site 298653008649 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 298653008650 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 298653008651 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 298653008652 putative NADP binding site [chemical binding]; other site 298653008653 active site 298653008654 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 298653008655 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 298653008656 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 298653008657 active site 298653008658 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 298653008659 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 298653008660 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 298653008661 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 298653008662 putative NADP binding site [chemical binding]; other site 298653008663 active site 298653008664 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 298653008665 Protein of unknown function (DUF1271); Region: DUF1271; pfam06902 298653008666 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 298653008667 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653008668 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 298653008669 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 298653008670 Walker A/P-loop; other site 298653008671 ATP binding site [chemical binding]; other site 298653008672 Q-loop/lid; other site 298653008673 ABC transporter signature motif; other site 298653008674 Walker B; other site 298653008675 D-loop; other site 298653008676 H-loop/switch region; other site 298653008677 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 298653008678 Walker A/P-loop; other site 298653008679 ATP binding site [chemical binding]; other site 298653008680 Q-loop/lid; other site 298653008681 ABC transporter signature motif; other site 298653008682 Walker B; other site 298653008683 D-loop; other site 298653008684 H-loop/switch region; other site 298653008685 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 298653008686 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 298653008687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653008688 dimer interface [polypeptide binding]; other site 298653008689 conserved gate region; other site 298653008690 ABC-ATPase subunit interface; other site 298653008691 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 298653008692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653008693 dimer interface [polypeptide binding]; other site 298653008694 conserved gate region; other site 298653008695 putative PBP binding loops; other site 298653008696 ABC-ATPase subunit interface; other site 298653008697 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 298653008698 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 298653008699 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 298653008700 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653008701 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653008702 putative substrate translocation pore; other site 298653008703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653008704 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653008705 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653008706 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 298653008707 Alpha/beta hydrolase of unknown function (DUF1100); Region: DUF1100; pfam06500 298653008708 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 298653008709 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 298653008710 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 298653008711 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 298653008712 active site 298653008713 RHS Repeat; Region: RHS_repeat; pfam05593 298653008714 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 298653008715 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 298653008716 RHS Repeat; Region: RHS_repeat; cl11982 298653008717 RHS Repeat; Region: RHS_repeat; pfam05593 298653008718 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 298653008719 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 298653008720 DNA binding site [nucleotide binding] 298653008721 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 298653008722 AAA ATPase domain; Region: AAA_16; pfam13191 298653008723 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653008724 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653008725 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653008726 DNA binding residues [nucleotide binding] 298653008727 dimerization interface [polypeptide binding]; other site 298653008728 acyl-CoA synthetase; Validated; Region: PRK07787 298653008729 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653008730 Domain of unknown function (DUF4009); Region: DUF4009; pfam13193 298653008731 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 298653008732 Transcriptional regulators [Transcription]; Region: GntR; COG1802 298653008733 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 298653008734 DNA-binding site [nucleotide binding]; DNA binding site 298653008735 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 298653008736 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 298653008737 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 298653008738 active site 298653008739 non-prolyl cis peptide bond; other site 298653008740 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 298653008741 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 298653008742 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 298653008743 tetramer interface [polypeptide binding]; other site 298653008744 active site 298653008745 Mg2+/Mn2+ binding site [ion binding]; other site 298653008746 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 298653008747 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 298653008748 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 298653008749 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 298653008750 HEAT repeats; Region: HEAT_2; pfam13646 298653008751 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 298653008752 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 298653008753 Probable transposase; Region: OrfB_IS605; pfam01385 298653008754 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 298653008755 Transposase IS200 like; Region: Y1_Tnp; cl00848 298653008756 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 298653008757 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 298653008758 catalytic loop [active] 298653008759 iron binding site [ion binding]; other site 298653008760 Restriction endonuclease; Region: Mrr_cat; pfam04471 298653008761 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 298653008762 Probable transposase; Region: OrfB_IS605; pfam01385 298653008763 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 298653008764 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 298653008765 AAA domain; Region: AAA_17; pfam13207 298653008766 active site 298653008767 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 298653008768 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 298653008769 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 298653008770 phosphate binding site [ion binding]; other site 298653008771 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 298653008772 putative hydrophobic ligand binding site [chemical binding]; other site 298653008773 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 298653008774 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 298653008775 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 298653008776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653008777 S-adenosylmethionine binding site [chemical binding]; other site 298653008778 Phosphotransferase enzyme family; Region: APH; pfam01636 298653008779 active site 298653008780 ATP binding site [chemical binding]; other site 298653008781 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 298653008782 protein-L-isoaspartate O-methyltransferase; Provisional; Region: PRK13942 298653008783 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 298653008784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653008785 S-adenosylmethionine binding site [chemical binding]; other site 298653008786 TIR domain; Region: TIR_2; pfam13676 298653008787 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 298653008788 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653008789 NAD(P) binding site [chemical binding]; other site 298653008790 active site 298653008791 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 298653008792 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 298653008793 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 298653008794 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 298653008795 dimerization interface [polypeptide binding]; other site 298653008796 substrate binding pocket [chemical binding]; other site 298653008797 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 298653008798 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653008799 NAD(P) binding pocket [chemical binding]; other site 298653008800 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653008801 classical (c) SDRs; Region: SDR_c; cd05233 298653008802 NAD(P) binding site [chemical binding]; other site 298653008803 active site 298653008804 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653008805 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 298653008806 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 298653008807 putative NAD(P) binding site [chemical binding]; other site 298653008808 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 298653008809 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 298653008810 NAD(P) binding site [chemical binding]; other site 298653008811 Transposase domain (DUF772); Region: DUF772; pfam05598 298653008812 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 298653008813 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 298653008814 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653008815 ABC transporter signature motif; other site 298653008816 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653008817 H-loop/switch region; other site 298653008818 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 298653008819 dimerization interface [polypeptide binding]; other site 298653008820 putative DNA binding site [nucleotide binding]; other site 298653008821 putative Zn2+ binding site [ion binding]; other site 298653008822 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 298653008823 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 298653008824 THF binding site; other site 298653008825 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 298653008826 substrate binding site [chemical binding]; other site 298653008827 THF binding site; other site 298653008828 zinc-binding site [ion binding]; other site 298653008829 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 298653008830 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 298653008831 putative ligand binding site [chemical binding]; other site 298653008832 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 298653008833 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 298653008834 dimer interface [polypeptide binding]; other site 298653008835 putative PBP binding regions; other site 298653008836 ABC-ATPase subunit interface; other site 298653008837 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 298653008838 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 298653008839 Walker A/P-loop; other site 298653008840 ATP binding site [chemical binding]; other site 298653008841 Q-loop/lid; other site 298653008842 ABC transporter signature motif; other site 298653008843 Walker B; other site 298653008844 D-loop; other site 298653008845 H-loop/switch region; other site 298653008846 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 298653008847 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 298653008848 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 298653008849 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 298653008850 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 298653008851 Walker A motif; other site 298653008852 ATP binding site [chemical binding]; other site 298653008853 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653008854 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653008855 DNA binding residues [nucleotide binding] 298653008856 dimerization interface [polypeptide binding]; other site 298653008857 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653008858 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 298653008859 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 298653008860 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 298653008861 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653008862 Walker A/P-loop; other site 298653008863 ATP binding site [chemical binding]; other site 298653008864 Q-loop/lid; other site 298653008865 ABC transporter signature motif; other site 298653008866 Walker B; other site 298653008867 D-loop; other site 298653008868 H-loop/switch region; other site 298653008869 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 298653008870 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 298653008871 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653008872 Walker A/P-loop; other site 298653008873 ATP binding site [chemical binding]; other site 298653008874 Q-loop/lid; other site 298653008875 ABC transporter signature motif; other site 298653008876 Walker B; other site 298653008877 D-loop; other site 298653008878 H-loop/switch region; other site 298653008879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653008880 Major Facilitator Superfamily; Region: MFS_1; pfam07690 298653008881 putative substrate translocation pore; other site 298653008882 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 298653008883 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 298653008884 Walker A/P-loop; other site 298653008885 ATP binding site [chemical binding]; other site 298653008886 Q-loop/lid; other site 298653008887 ABC transporter signature motif; other site 298653008888 Walker B; other site 298653008889 D-loop; other site 298653008890 H-loop/switch region; other site 298653008891 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 298653008892 Walker A/P-loop; other site 298653008893 ATP binding site [chemical binding]; other site 298653008894 Q-loop/lid; other site 298653008895 ABC transporter signature motif; other site 298653008896 Walker B; other site 298653008897 D-loop; other site 298653008898 H-loop/switch region; other site 298653008899 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 298653008900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653008901 dimer interface [polypeptide binding]; other site 298653008902 ABC-ATPase subunit interface; other site 298653008903 putative PBP binding loops; other site 298653008904 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 298653008905 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653008906 dimer interface [polypeptide binding]; other site 298653008907 conserved gate region; other site 298653008908 putative PBP binding loops; other site 298653008909 ABC-ATPase subunit interface; other site 298653008910 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 298653008911 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 298653008912 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653008913 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 298653008914 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653008915 NAD(P) binding pocket [chemical binding]; other site 298653008916 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 298653008917 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653008918 dimerization interface [polypeptide binding]; other site 298653008919 putative DNA binding site [nucleotide binding]; other site 298653008920 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 298653008921 putative Zn2+ binding site [ion binding]; other site 298653008922 HEAT repeats; Region: HEAT_2; pfam13646 298653008923 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 298653008924 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 298653008925 DNA binding residues [nucleotide binding] 298653008926 putative dimer interface [polypeptide binding]; other site 298653008927 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 298653008928 putative dimer interface [polypeptide binding]; other site 298653008929 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 298653008930 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653008931 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653008932 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 298653008933 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 298653008934 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 298653008935 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 298653008936 DNA binding residues [nucleotide binding] 298653008937 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 298653008938 NADH dehydrogenase-like protein; Provisional; Region: PTZ00318 298653008939 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 298653008940 short chain dehydrogenase; Provisional; Region: PRK06197 298653008941 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 298653008942 putative NAD(P) binding site [chemical binding]; other site 298653008943 active site 298653008944 Helix-turn-helix domain; Region: HTH_31; pfam13560 298653008945 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653008946 NADH(P)-binding; Region: NAD_binding_10; pfam13460 298653008947 NAD(P) binding site [chemical binding]; other site 298653008948 active site 298653008949 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 298653008950 MULE transposase domain; Region: MULE; pfam10551 298653008951 Homeodomain-like domain; Region: HTH_23; pfam13384 298653008952 Winged helix-turn helix; Region: HTH_29; pfam13551 298653008953 Homeodomain-like domain; Region: HTH_32; pfam13565 298653008954 DDE superfamily endonuclease; Region: DDE_3; pfam13358 298653008955 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653008956 classical (c) SDRs; Region: SDR_c; cd05233 298653008957 NAD(P) binding site [chemical binding]; other site 298653008958 active site 298653008959 tricarballylate dehydrogenase; Validated; Region: PRK08274 298653008960 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 298653008961 TM-ABC transporter signature motif; other site 298653008962 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 298653008963 TM-ABC transporter signature motif; other site 298653008964 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 298653008965 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 298653008966 Walker A/P-loop; other site 298653008967 ATP binding site [chemical binding]; other site 298653008968 Q-loop/lid; other site 298653008969 ABC transporter signature motif; other site 298653008970 Walker B; other site 298653008971 D-loop; other site 298653008972 H-loop/switch region; other site 298653008973 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653008974 Walker A/P-loop; other site 298653008975 ATP binding site [chemical binding]; other site 298653008976 Q-loop/lid; other site 298653008977 ABC transporter signature motif; other site 298653008978 Walker B; other site 298653008979 D-loop; other site 298653008980 H-loop/switch region; other site 298653008981 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653008982 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 298653008983 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653008984 active site 298653008985 enoyl-CoA hydratase; Provisional; Region: PRK06688 298653008986 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653008987 substrate binding site [chemical binding]; other site 298653008988 oxyanion hole (OAH) forming residues; other site 298653008989 trimer interface [polypeptide binding]; other site 298653008990 DUF35 OB-fold domain; Region: DUF35; pfam01796 298653008991 lipid-transfer protein; Provisional; Region: PRK08256 298653008992 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 298653008993 active site 298653008994 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653008995 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 298653008996 active site 298653008997 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 298653008998 putative active site [active] 298653008999 putative substrate binding site [chemical binding]; other site 298653009000 ATP binding site [chemical binding]; other site 298653009001 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653009002 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653009003 active site 298653009004 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653009005 classical (c) SDRs; Region: SDR_c; cd05233 298653009006 NAD(P) binding site [chemical binding]; other site 298653009007 active site 298653009008 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 298653009009 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653009010 NAD(P) binding site [chemical binding]; other site 298653009011 active site 298653009012 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653009013 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653009014 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 298653009015 classical (c) SDRs; Region: SDR_c; cd05233 298653009016 NAD(P) binding site [chemical binding]; other site 298653009017 active site 298653009018 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 298653009019 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653009020 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 298653009021 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653009022 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653009023 classical (c) SDRs; Region: SDR_c; cd05233 298653009024 NAD(P) binding site [chemical binding]; other site 298653009025 active site 298653009026 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653009027 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653009028 NAD(P) binding site [chemical binding]; other site 298653009029 active site 298653009030 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 298653009031 Divergent AAA domain; Region: AAA_4; pfam04326 298653009032 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 298653009033 Cupin domain; Region: Cupin_2; pfam07883 298653009034 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 298653009035 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 298653009036 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 298653009037 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 298653009038 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 298653009039 active site 298653009040 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 298653009041 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 298653009042 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 298653009043 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 298653009044 NADP binding site [chemical binding]; other site 298653009045 active site 298653009046 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 298653009047 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653009048 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 298653009049 AMP-binding enzyme; Region: AMP-binding; cl15778 298653009050 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 298653009051 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827 298653009052 dimer interface [polypeptide binding]; other site 298653009053 active site 298653009054 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 298653009055 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653009056 AMP-binding enzyme; Region: AMP-binding; cl15778 298653009057 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 298653009058 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 298653009059 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 298653009060 active site 298653009061 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 298653009062 Isochorismatase family; Region: Isochorismatase; pfam00857 298653009063 catalytic triad [active] 298653009064 conserved cis-peptide bond; other site 298653009065 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 298653009066 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 298653009067 Glutamine amidotransferase class-I; Region: GATase; pfam00117 298653009068 glutamine binding [chemical binding]; other site 298653009069 catalytic triad [active] 298653009070 Predicted transcriptional regulators [Transcription]; Region: COG1733 298653009071 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 298653009072 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 298653009073 NADP binding site [chemical binding]; other site 298653009074 Helix-turn-helix domain; Region: HTH_31; pfam13560 298653009075 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 298653009076 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 298653009077 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 298653009078 Helix-turn-helix domains; Region: HTH; cl00088 298653009079 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653009080 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 298653009081 active site 298653009082 ATP binding site [chemical binding]; other site 298653009083 substrate binding site [chemical binding]; other site 298653009084 activation loop (A-loop); other site 298653009085 Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077 298653009086 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 298653009087 nucleotide binding site [chemical binding]; other site 298653009088 putative NEF/HSP70 interaction site [polypeptide binding]; other site 298653009089 SBD interface [polypeptide binding]; other site 298653009090 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 298653009091 CHAT domain; Region: CHAT; pfam12770 298653009092 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653009093 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 298653009094 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 298653009095 TPR motif; other site 298653009096 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653009097 binding surface 298653009098 TPR repeat; Region: TPR_11; pfam13414 298653009099 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653009100 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 298653009101 binding surface 298653009102 TPR motif; other site 298653009103 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653009104 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653009105 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653009106 TIR domain; Region: TIR_2; pfam13676 298653009107 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 298653009108 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 298653009109 FMN binding site [chemical binding]; other site 298653009110 dimer interface [polypeptide binding]; other site 298653009111 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 298653009112 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 298653009113 DNA binding residues [nucleotide binding] 298653009114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 298653009115 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653009116 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653009117 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 298653009118 MMPL family; Region: MMPL; pfam03176 298653009119 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653009120 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 298653009121 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 298653009122 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 298653009123 FAD binding pocket [chemical binding]; other site 298653009124 FAD binding motif [chemical binding]; other site 298653009125 phosphate binding motif [ion binding]; other site 298653009126 NAD binding pocket [chemical binding]; other site 298653009127 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 298653009128 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 298653009129 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 298653009130 Major Facilitator Superfamily; Region: MFS_1; pfam07690 298653009131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653009132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653009133 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653009134 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 298653009135 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 298653009136 putative NAD(P) binding site [chemical binding]; other site 298653009137 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653009138 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 298653009139 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 298653009140 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 298653009141 dimer interface [polypeptide binding]; other site 298653009142 active site 298653009143 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 298653009144 nudix motif; other site 298653009145 MarR family; Region: MarR; pfam01047 298653009146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653009147 Major Facilitator Superfamily; Region: MFS_1; pfam07690 298653009148 putative substrate translocation pore; other site 298653009149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653009150 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 298653009151 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 298653009152 putative DNA binding site [nucleotide binding]; other site 298653009153 catalytic residue [active] 298653009154 putative H2TH interface [polypeptide binding]; other site 298653009155 putative catalytic residues [active] 298653009156 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 298653009157 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 298653009158 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 298653009159 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653009160 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 298653009161 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653009162 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 298653009163 catalytic triad [active] 298653009164 dimer interface [polypeptide binding]; other site 298653009165 decamer (pentamer of dimers) interface [polypeptide binding]; other site 298653009166 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 298653009167 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 298653009168 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 298653009169 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 298653009170 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 298653009171 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 298653009172 active site 298653009173 catalytic tetrad [active] 298653009174 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 298653009175 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 298653009176 catalytic triad [active] 298653009177 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR4; cd08270 298653009178 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 298653009179 putative NAD(P) binding site [chemical binding]; other site 298653009180 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653009181 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 298653009182 putative ligand binding site [chemical binding]; other site 298653009183 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653009184 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 298653009185 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 298653009186 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 298653009187 DXD motif; other site 298653009188 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 298653009189 FAD dependent oxidoreductase; Region: DAO; pfam01266 298653009190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653009191 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653009192 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 298653009193 apolar tunnel; other site 298653009194 heme binding site [chemical binding]; other site 298653009195 dimerization interface [polypeptide binding]; other site 298653009196 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653009197 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653009198 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 298653009199 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 298653009200 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 298653009201 catalytic tetrad [active] 298653009202 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 298653009203 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 298653009204 [2Fe-2S] cluster binding site [ion binding]; other site 298653009205 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 298653009206 alpha subunit interface [polypeptide binding]; other site 298653009207 active site 298653009208 substrate binding site [chemical binding]; other site 298653009209 Fe binding site [ion binding]; other site 298653009210 PPOX class probable F420-dependent enzyme, MSMEG_5819 family; Region: PPOX_MSMEG_5819; TIGR04023 298653009211 SnoaL-like domain; Region: SnoaL_4; pfam13577 298653009212 SnoaL-like domain; Region: SnoaL_4; pfam13577 298653009213 short chain dehydrogenase; Provisional; Region: PRK08278 298653009214 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653009215 NAD(P) binding site [chemical binding]; other site 298653009216 active site 298653009217 Amidohydrolase; Region: Amidohydro_2; pfam04909 298653009218 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653009219 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653009220 active site 298653009221 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653009222 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 298653009223 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 298653009224 active site 298653009225 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653009226 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653009227 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 298653009228 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 298653009229 classical (c) SDRs; Region: SDR_c; cd05233 298653009230 NAD(P) binding site [chemical binding]; other site 298653009231 active site 298653009232 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 298653009233 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 298653009234 [2Fe-2S] cluster binding site [ion binding]; other site 298653009235 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 298653009236 hydrophobic ligand binding site; other site 298653009237 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 298653009238 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653009239 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653009240 NAD(P) binding site [chemical binding]; other site 298653009241 active site 298653009242 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 298653009243 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 298653009244 PYR/PP interface [polypeptide binding]; other site 298653009245 dimer interface [polypeptide binding]; other site 298653009246 TPP binding site [chemical binding]; other site 298653009247 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 298653009248 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 298653009249 TPP-binding site; other site 298653009250 dimer interface [polypeptide binding]; other site 298653009251 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 298653009252 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 298653009253 NAD binding site [chemical binding]; other site 298653009254 catalytic residues [active] 298653009255 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 298653009256 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 298653009257 NADP binding site [chemical binding]; other site 298653009258 dimer interface [polypeptide binding]; other site 298653009259 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 298653009260 active site 298653009261 catalytic site [active] 298653009262 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 298653009263 active site 2 [active] 298653009264 active site 1 [active] 298653009265 AMP-binding domain protein; Validated; Region: PRK08315 298653009266 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653009267 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 298653009268 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 298653009269 substrate binding pocket [chemical binding]; other site 298653009270 active site 298653009271 iron coordination sites [ion binding]; other site 298653009272 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 298653009273 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653009274 NAD(P) binding site [chemical binding]; other site 298653009275 active site 298653009276 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 298653009277 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 298653009278 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653009279 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653009280 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653009281 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 298653009282 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653009283 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653009284 NAD(P) binding site [chemical binding]; other site 298653009285 active site 298653009286 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653009287 classical (c) SDRs; Region: SDR_c; cd05233 298653009288 NAD(P) binding site [chemical binding]; other site 298653009289 active site 298653009290 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 298653009291 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 298653009292 DNA-binding site [nucleotide binding]; DNA binding site 298653009293 FCD domain; Region: FCD; pfam07729 298653009294 Uncharacterized conserved protein [Function unknown]; Region: COG2128 298653009295 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 298653009296 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653009297 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653009298 NAD(P) binding site [chemical binding]; other site 298653009299 active site 298653009300 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 298653009301 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 298653009302 active site 298653009303 iron coordination sites [ion binding]; other site 298653009304 substrate binding pocket [chemical binding]; other site 298653009305 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 298653009306 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 298653009307 PYR/PP interface [polypeptide binding]; other site 298653009308 dimer interface [polypeptide binding]; other site 298653009309 TPP binding site [chemical binding]; other site 298653009310 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 298653009311 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 298653009312 TPP-binding site; other site 298653009313 dimer interface [polypeptide binding]; other site 298653009314 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 298653009315 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 298653009316 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 298653009317 phosphate binding site [ion binding]; other site 298653009318 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653009319 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653009320 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 298653009321 active site 298653009322 catalytic residues [active] 298653009323 metal binding site [ion binding]; metal-binding site 298653009324 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 298653009325 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 298653009326 active site 298653009327 TDP-binding site; other site 298653009328 acceptor substrate-binding pocket; other site 298653009329 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653009330 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653009331 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 298653009332 active site 298653009333 catalytic triad [active] 298653009334 oxyanion hole [active] 298653009335 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653009336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653009337 active site 298653009338 phosphorylation site [posttranslational modification] 298653009339 intermolecular recognition site; other site 298653009340 dimerization interface [polypeptide binding]; other site 298653009341 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653009342 DNA binding residues [nucleotide binding] 298653009343 dimerization interface [polypeptide binding]; other site 298653009344 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 298653009345 Histidine kinase; Region: HisKA_3; pfam07730 298653009346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653009347 ATP binding site [chemical binding]; other site 298653009348 Mg2+ binding site [ion binding]; other site 298653009349 G-X-G motif; other site 298653009350 MMPL family; Region: MMPL; pfam03176 298653009351 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 298653009352 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 298653009353 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 298653009354 active site 298653009355 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 298653009356 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653009357 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653009358 The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6, and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348 298653009359 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 298653009360 putative active site [active] 298653009361 putative metal binding site [ion binding]; other site 298653009362 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 298653009363 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 298653009364 putative NAD(P) binding site [chemical binding]; other site 298653009365 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 298653009366 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 298653009367 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653009368 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653009369 active site 298653009370 ATP binding site [chemical binding]; other site 298653009371 substrate binding site [chemical binding]; other site 298653009372 activation loop (A-loop); other site 298653009373 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 298653009374 FOG: WD40 repeat [General function prediction only]; Region: COG2319 298653009375 structural tetrad; other site 298653009376 oxidoreductase; Provisional; Region: PRK06196 298653009377 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 298653009378 putative NAD(P) binding site [chemical binding]; other site 298653009379 active site 298653009380 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653009381 metal binding site [ion binding]; metal-binding site 298653009382 active site 298653009383 I-site; other site 298653009384 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 298653009385 AMP-binding enzyme; Region: AMP-binding; cl15778 298653009386 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 298653009387 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 298653009388 NAD(P) binding site [chemical binding]; other site 298653009389 catalytic residues [active] 298653009390 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 298653009391 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 298653009392 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 298653009393 catalytic Zn binding site [ion binding]; other site 298653009394 NAD(P) binding site [chemical binding]; other site 298653009395 structural Zn binding site [ion binding]; other site 298653009396 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653009397 salt bridge; other site 298653009398 non-specific DNA binding site [nucleotide binding]; other site 298653009399 sequence-specific DNA binding site [nucleotide binding]; other site 298653009400 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 298653009401 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 298653009402 Walker A/P-loop; other site 298653009403 ATP binding site [chemical binding]; other site 298653009404 Q-loop/lid; other site 298653009405 ABC transporter signature motif; other site 298653009406 Walker B; other site 298653009407 D-loop; other site 298653009408 H-loop/switch region; other site 298653009409 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 298653009410 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 298653009411 Walker A/P-loop; other site 298653009412 ATP binding site [chemical binding]; other site 298653009413 Q-loop/lid; other site 298653009414 ABC transporter signature motif; other site 298653009415 Walker B; other site 298653009416 D-loop; other site 298653009417 H-loop/switch region; other site 298653009418 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 298653009419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653009420 dimer interface [polypeptide binding]; other site 298653009421 conserved gate region; other site 298653009422 putative PBP binding loops; other site 298653009423 ABC-ATPase subunit interface; other site 298653009424 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 298653009425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653009426 dimer interface [polypeptide binding]; other site 298653009427 conserved gate region; other site 298653009428 putative PBP binding loops; other site 298653009429 ABC-ATPase subunit interface; other site 298653009430 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 298653009431 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 298653009432 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653009433 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 298653009434 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 298653009435 active site 298653009436 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 298653009437 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 298653009438 dimer interface [polypeptide binding]; other site 298653009439 active site 298653009440 non-prolyl cis peptide bond; other site 298653009441 insertion regions; other site 298653009442 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 298653009443 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 298653009444 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 298653009445 active site 298653009446 DNA binding site [nucleotide binding] 298653009447 catalytic site [active] 298653009448 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 298653009449 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 298653009450 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653009451 Walker A/P-loop; other site 298653009452 ATP binding site [chemical binding]; other site 298653009453 ABC transporter; Region: ABC_tran; pfam00005 298653009454 Q-loop/lid; other site 298653009455 ABC transporter signature motif; other site 298653009456 Walker B; other site 298653009457 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 298653009458 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14270 298653009459 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653009460 Walker A/P-loop; other site 298653009461 ATP binding site [chemical binding]; other site 298653009462 Q-loop/lid; other site 298653009463 ABC transporter signature motif; other site 298653009464 Walker B; other site 298653009465 D-loop; other site 298653009466 H-loop/switch region; other site 298653009467 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 298653009468 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653009469 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 298653009470 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 298653009471 HsdM N-terminal domain; Region: HsdM_N; pfam12161 298653009472 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 298653009473 Methyltransferase domain; Region: Methyltransf_26; pfam13659 298653009474 S-adenosylmethionine binding site [chemical binding]; other site 298653009475 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 298653009476 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 298653009477 FOG: WD40 repeat [General function prediction only]; Region: COG2319 298653009478 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 298653009479 structural tetrad; other site 298653009480 HerA helicase [Replication, recombination, and repair]; Region: COG0433 298653009481 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 298653009482 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 298653009483 active site 298653009484 metal binding site [ion binding]; metal-binding site 298653009485 DNA binding site [nucleotide binding] 298653009486 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 298653009487 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653009488 Walker A/P-loop; other site 298653009489 ATP binding site [chemical binding]; other site 298653009490 Q-loop/lid; other site 298653009491 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 298653009492 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653009493 Q-loop/lid; other site 298653009494 ABC transporter signature motif; other site 298653009495 Walker B; other site 298653009496 D-loop; other site 298653009497 H-loop/switch region; other site 298653009498 NurA domain; Region: NurA; cl09134 298653009499 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 298653009500 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653009501 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 298653009502 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 298653009503 active site 298653009504 metal binding site [ion binding]; metal-binding site 298653009505 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 298653009506 putative active site [active] 298653009507 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 298653009508 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 298653009509 active site 298653009510 catalytic tetrad [active] 298653009511 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 298653009512 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 298653009513 dimer interface [polypeptide binding]; other site 298653009514 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 298653009515 active site 298653009516 Fe binding site [ion binding]; other site 298653009517 Cupin domain; Region: Cupin_2; cl09118 298653009518 fumarylacetoacetase; Region: PLN02856 298653009519 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 298653009520 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 298653009521 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 298653009522 putative DNA binding site [nucleotide binding]; other site 298653009523 dimerization interface [polypeptide binding]; other site 298653009524 putative Zn2+ binding site [ion binding]; other site 298653009525 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653009526 AAA ATPase domain; Region: AAA_16; pfam13191 298653009527 AAA ATPase domain; Region: AAA_16; pfam13191 298653009528 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653009529 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653009530 DNA binding residues [nucleotide binding] 298653009531 dimerization interface [polypeptide binding]; other site 298653009532 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 298653009533 nucleotide binding site [chemical binding]; other site 298653009534 putative NEF/HSP70 interaction site [polypeptide binding]; other site 298653009535 SBD interface [polypeptide binding]; other site 298653009536 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 298653009537 Interdomain contacts; other site 298653009538 Cytokine receptor motif; other site 298653009539 MoxR-like ATPases [General function prediction only]; Region: COG0714 298653009540 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 298653009541 ATP binding site [chemical binding]; other site 298653009542 Walker A motif; other site 298653009543 Walker B motif; other site 298653009544 arginine finger; other site 298653009545 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 298653009546 Protein of unknown function DUF58; Region: DUF58; pfam01882 298653009547 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 298653009548 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 298653009549 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 298653009550 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653009551 G1 box; other site 298653009552 GTP/Mg2+ binding site [chemical binding]; other site 298653009553 G2 box; other site 298653009554 Switch I region; other site 298653009555 G3 box; other site 298653009556 Switch II region; other site 298653009557 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653009558 G1 box; other site 298653009559 GTP/Mg2+ binding site [chemical binding]; other site 298653009560 G2 box; other site 298653009561 Switch I region; other site 298653009562 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653009563 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653009564 DNA binding residues [nucleotide binding] 298653009565 dimerization interface [polypeptide binding]; other site 298653009566 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 298653009567 NlpC/P60 family; Region: NLPC_P60; cl11438 298653009568 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 298653009569 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 298653009570 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 298653009571 Walker A motif; other site 298653009572 ATP binding site [chemical binding]; other site 298653009573 Walker B motif; other site 298653009574 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 298653009575 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 298653009576 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 298653009577 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 298653009578 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 298653009579 Phage protein D [General function prediction only]; Region: COG3500 298653009580 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 298653009581 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 298653009582 Baseplate J-like protein; Region: Baseplate_J; cl01294 298653009583 Baseplate J-like protein; Region: Baseplate_J; cl01294 298653009584 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 298653009585 DNA binding site [nucleotide binding] 298653009586 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 298653009587 Bacterial transcriptional activator domain; Region: BTAD; smart01043 298653009588 Double zinc ribbon; Region: DZR; pfam12773 298653009589 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 298653009590 Integrase core domain; Region: rve_3; pfam13683 298653009591 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 298653009592 Histidine kinase; Region: HisKA_3; pfam07730 298653009593 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653009594 ATP binding site [chemical binding]; other site 298653009595 Mg2+ binding site [ion binding]; other site 298653009596 G-X-G motif; other site 298653009597 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653009598 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653009599 active site 298653009600 phosphorylation site [posttranslational modification] 298653009601 intermolecular recognition site; other site 298653009602 dimerization interface [polypeptide binding]; other site 298653009603 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653009604 DNA binding residues [nucleotide binding] 298653009605 dimerization interface [polypeptide binding]; other site 298653009606 Transposase domain (DUF772); Region: DUF772; pfam05598 298653009607 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 298653009608 Integrase core domain; Region: rve; pfam00665 298653009609 Integrase core domain; Region: rve_3; pfam13683 298653009610 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 298653009611 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653009612 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 298653009613 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 298653009614 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 298653009615 putative NAD(P) binding site [chemical binding]; other site 298653009616 catalytic Zn binding site [ion binding]; other site 298653009617 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653009618 classical (c) SDRs; Region: SDR_c; cd05233 298653009619 NAD(P) binding site [chemical binding]; other site 298653009620 active site 298653009621 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 298653009622 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 298653009623 NAD(P) binding site [chemical binding]; other site 298653009624 catalytic residues [active] 298653009625 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 298653009626 Tubby C 2; Region: Tub_2; cl02043 298653009627 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 298653009628 Histidine kinase; Region: HisKA_3; pfam07730 298653009629 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653009630 ATP binding site [chemical binding]; other site 298653009631 Mg2+ binding site [ion binding]; other site 298653009632 G-X-G motif; other site 298653009633 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653009634 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653009635 active site 298653009636 phosphorylation site [posttranslational modification] 298653009637 intermolecular recognition site; other site 298653009638 dimerization interface [polypeptide binding]; other site 298653009639 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653009640 DNA binding residues [nucleotide binding] 298653009641 dimerization interface [polypeptide binding]; other site 298653009642 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 298653009643 Cupin; Region: Cupin_6; pfam12852 298653009644 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 298653009645 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 298653009646 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 298653009647 Transposase IS200 like; Region: Y1_Tnp; pfam01797 298653009648 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 298653009649 EthD domain; Region: EthD; pfam07110 298653009650 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 298653009651 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 298653009652 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 298653009653 ring oligomerisation interface [polypeptide binding]; other site 298653009654 ATP/Mg binding site [chemical binding]; other site 298653009655 stacking interactions; other site 298653009656 hinge regions; other site 298653009657 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653009658 substrate binding site [chemical binding]; other site 298653009659 activation loop (A-loop); other site 298653009660 AAA ATPase domain; Region: AAA_16; pfam13191 298653009661 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 298653009662 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 298653009663 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653009664 metal binding site [ion binding]; metal-binding site 298653009665 active site 298653009666 I-site; other site 298653009667 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 298653009668 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 298653009669 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 298653009670 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 298653009671 phosphorylation site [posttranslational modification] 298653009672 dimer interface [polypeptide binding]; other site 298653009673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653009674 ATP binding site [chemical binding]; other site 298653009675 Mg2+ binding site [ion binding]; other site 298653009676 G-X-G motif; other site 298653009677 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 298653009678 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653009679 active site 298653009680 phosphorylation site [posttranslational modification] 298653009681 intermolecular recognition site; other site 298653009682 dimerization interface [polypeptide binding]; other site 298653009683 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 298653009684 DNA binding site [nucleotide binding] 298653009685 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 298653009686 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 298653009687 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 298653009688 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 298653009689 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 298653009690 active site 298653009691 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 298653009692 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653009693 Predicted amidohydrolase [General function prediction only]; Region: COG0388 298653009694 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 298653009695 putative active site [active] 298653009696 catalytic triad [active] 298653009697 putative dimer interface [polypeptide binding]; other site 298653009698 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 298653009699 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653009700 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 298653009701 TM-ABC transporter signature motif; other site 298653009702 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 298653009703 TM-ABC transporter signature motif; other site 298653009704 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 298653009705 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 298653009706 Walker A/P-loop; other site 298653009707 ATP binding site [chemical binding]; other site 298653009708 Q-loop/lid; other site 298653009709 ABC transporter signature motif; other site 298653009710 Walker B; other site 298653009711 D-loop; other site 298653009712 H-loop/switch region; other site 298653009713 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 298653009714 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 298653009715 Walker A/P-loop; other site 298653009716 ATP binding site [chemical binding]; other site 298653009717 Q-loop/lid; other site 298653009718 ABC transporter signature motif; other site 298653009719 Walker B; other site 298653009720 D-loop; other site 298653009721 H-loop/switch region; other site 298653009722 NMT1-like family; Region: NMT1_2; cl15260 298653009723 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 298653009724 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 298653009725 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653009726 dimer interface [polypeptide binding]; other site 298653009727 conserved gate region; other site 298653009728 putative PBP binding loops; other site 298653009729 ABC-ATPase subunit interface; other site 298653009730 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 298653009731 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653009732 Walker A/P-loop; other site 298653009733 ATP binding site [chemical binding]; other site 298653009734 Q-loop/lid; other site 298653009735 ABC transporter signature motif; other site 298653009736 Walker B; other site 298653009737 D-loop; other site 298653009738 H-loop/switch region; other site 298653009739 oxidoreductase; Provisional; Region: PRK06196 298653009740 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653009741 NAD(P) binding site [chemical binding]; other site 298653009742 active site 298653009743 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 298653009744 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653009745 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 298653009746 Walker A/P-loop; other site 298653009747 ATP binding site [chemical binding]; other site 298653009748 Q-loop/lid; other site 298653009749 ABC transporter signature motif; other site 298653009750 Walker B; other site 298653009751 D-loop; other site 298653009752 H-loop/switch region; other site 298653009753 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 298653009754 Glutamine amidotransferase class-I; Region: GATase; pfam00117 298653009755 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 298653009756 glutamine binding [chemical binding]; other site 298653009757 catalytic triad [active] 298653009758 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 298653009759 Protein of unknown function (DUF664); Region: DUF664; pfam04978 298653009760 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 298653009761 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 298653009762 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 298653009763 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 298653009764 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 298653009765 active site 298653009766 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 298653009767 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 298653009768 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 298653009769 NADP binding site [chemical binding]; other site 298653009770 active site 298653009771 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 298653009772 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 298653009773 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 298653009774 active site 298653009775 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 298653009776 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 298653009777 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 298653009778 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 298653009779 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 298653009780 active site 298653009781 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 298653009782 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 298653009783 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 298653009784 putative NADP binding site [chemical binding]; other site 298653009785 active site 298653009786 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 298653009787 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 298653009788 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 298653009789 active site 298653009790 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 298653009791 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 298653009792 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 298653009793 NADP binding site [chemical binding]; other site 298653009794 active site 298653009795 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 298653009796 Erythronolide synthase docking; Region: Docking; pfam08990 298653009797 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 298653009798 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 298653009799 active site 298653009800 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 298653009801 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 298653009802 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 298653009803 NADP binding site [chemical binding]; other site 298653009804 active site 298653009805 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 298653009806 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 298653009807 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 298653009808 active site 298653009809 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 298653009810 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 298653009811 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 298653009812 putative NADP binding site [chemical binding]; other site 298653009813 active site 298653009814 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 298653009815 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 298653009816 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 298653009817 active site 298653009818 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 298653009819 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653009820 dimer interface [polypeptide binding]; other site 298653009821 conserved gate region; other site 298653009822 putative PBP binding loops; other site 298653009823 ABC-ATPase subunit interface; other site 298653009824 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 298653009825 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653009826 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653009827 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653009828 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653009829 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 298653009830 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 298653009831 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 298653009832 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653009833 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 298653009834 DinB superfamily; Region: DinB_2; pfam12867 298653009835 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 298653009836 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653009837 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653009838 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 298653009839 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 298653009840 heme-binding site [chemical binding]; other site 298653009841 Transposase domain (DUF772); Region: DUF772; pfam05598 298653009842 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 298653009843 Probable transposase; Region: OrfB_IS605; pfam01385 298653009844 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 298653009845 TOBE domain; Region: TOBE_2; cl01440 298653009846 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 298653009847 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 298653009848 DUF35 OB-fold domain; Region: DUF35; pfam01796 298653009849 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 298653009850 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 298653009851 active site 298653009852 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653009853 S-adenosylmethionine binding site [chemical binding]; other site 298653009854 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653009855 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653009856 NAD(P) binding site [chemical binding]; other site 298653009857 active site 298653009858 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 298653009859 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653009860 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 298653009861 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 298653009862 putative active site [active] 298653009863 putative catalytic site [active] 298653009864 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 298653009865 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 298653009866 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 298653009867 tetrameric interface [polypeptide binding]; other site 298653009868 NAD binding site [chemical binding]; other site 298653009869 catalytic residues [active] 298653009870 Amidohydrolase; Region: Amidohydro_2; pfam04909 298653009871 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 298653009872 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 298653009873 FMN binding site [chemical binding]; other site 298653009874 dimer interface [polypeptide binding]; other site 298653009875 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 298653009876 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 298653009877 Walker A/P-loop; other site 298653009878 ATP binding site [chemical binding]; other site 298653009879 Q-loop/lid; other site 298653009880 ABC transporter signature motif; other site 298653009881 Walker B; other site 298653009882 D-loop; other site 298653009883 H-loop/switch region; other site 298653009884 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 298653009885 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 298653009886 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 298653009887 Walker A/P-loop; other site 298653009888 ATP binding site [chemical binding]; other site 298653009889 Q-loop/lid; other site 298653009890 ABC transporter signature motif; other site 298653009891 Walker B; other site 298653009892 D-loop; other site 298653009893 H-loop/switch region; other site 298653009894 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 298653009895 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 298653009896 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 298653009897 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 298653009898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653009899 dimer interface [polypeptide binding]; other site 298653009900 conserved gate region; other site 298653009901 putative PBP binding loops; other site 298653009902 ABC-ATPase subunit interface; other site 298653009903 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 298653009904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653009905 dimer interface [polypeptide binding]; other site 298653009906 conserved gate region; other site 298653009907 putative PBP binding loops; other site 298653009908 ABC-ATPase subunit interface; other site 298653009909 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653009910 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 298653009911 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653009912 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653009913 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 298653009914 hypothetical protein; Reviewed; Region: PRK09588 298653009915 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653009916 NAD(P) binding site [chemical binding]; other site 298653009917 short chain dehydrogenase; Provisional; Region: PRK07060 298653009918 active site 298653009919 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 298653009920 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 298653009921 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 298653009922 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 298653009923 dimer interface [polypeptide binding]; other site 298653009924 active site 298653009925 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653009926 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653009927 active site 298653009928 acetolactate synthase; Reviewed; Region: PRK08322 298653009929 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 298653009930 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 298653009931 Transcriptional regulators [Transcription]; Region: GntR; COG1802 298653009932 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 298653009933 DNA-binding site [nucleotide binding]; DNA binding site 298653009934 FCD domain; Region: FCD; pfam07729 298653009935 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653009936 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653009937 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653009938 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 298653009939 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653009940 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653009941 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 298653009942 CoenzymeA binding site [chemical binding]; other site 298653009943 subunit interaction site [polypeptide binding]; other site 298653009944 PHB binding site; other site 298653009945 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653009946 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 298653009947 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 298653009948 dimerization interface [polypeptide binding]; other site 298653009949 substrate binding pocket [chemical binding]; other site 298653009950 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 298653009951 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 298653009952 FMN-binding pocket [chemical binding]; other site 298653009953 flavin binding motif; other site 298653009954 phosphate binding motif [ion binding]; other site 298653009955 beta-alpha-beta structure motif; other site 298653009956 NAD binding pocket [chemical binding]; other site 298653009957 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 298653009958 catalytic loop [active] 298653009959 iron binding site [ion binding]; other site 298653009960 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 298653009961 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653009962 Walker A/P-loop; other site 298653009963 ATP binding site [chemical binding]; other site 298653009964 Q-loop/lid; other site 298653009965 ABC transporter signature motif; other site 298653009966 Walker B; other site 298653009967 D-loop; other site 298653009968 H-loop/switch region; other site 298653009969 TOBE domain; Region: TOBE_2; pfam08402 298653009970 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 298653009971 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 298653009972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653009973 putative PBP binding loops; other site 298653009974 ABC-ATPase subunit interface; other site 298653009975 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 298653009976 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653009977 dimer interface [polypeptide binding]; other site 298653009978 conserved gate region; other site 298653009979 putative PBP binding loops; other site 298653009980 ABC-ATPase subunit interface; other site 298653009981 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 298653009982 putative catalytic site [active] 298653009983 putative metal binding site [ion binding]; other site 298653009984 putative phosphate binding site [ion binding]; other site 298653009985 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 298653009986 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 298653009987 ATP-grasp domain; Region: ATP-grasp_4; cl03087 298653009988 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 298653009989 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 298653009990 carboxyltransferase (CT) interaction site; other site 298653009991 biotinylation site [posttranslational modification]; other site 298653009992 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 298653009993 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 298653009994 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 298653009995 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 298653009996 phosphate binding site [ion binding]; other site 298653009997 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 298653009998 active site 2 [active] 298653009999 dimer interface [polypeptide binding]; other site 298653010000 active site 1 [active] 298653010001 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 298653010002 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 298653010003 active site 298653010004 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 298653010005 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 298653010006 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 298653010007 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 298653010008 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653010009 NAD(P) binding site [chemical binding]; other site 298653010010 active site 298653010011 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 298653010012 active site 298653010013 catalytic triad [active] 298653010014 oxyanion hole [active] 298653010015 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653010016 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 298653010017 nucleophilic elbow; other site 298653010018 catalytic triad; other site 298653010019 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 298653010020 CoenzymeA binding site [chemical binding]; other site 298653010021 subunit interaction site [polypeptide binding]; other site 298653010022 PHB binding site; other site 298653010023 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653010024 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 298653010025 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 298653010026 active site 298653010027 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 298653010028 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653010029 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 298653010030 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653010031 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 298653010032 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 298653010033 motif II; other site 298653010034 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 298653010035 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 298653010036 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 298653010037 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 298653010038 dimerization interface [polypeptide binding]; other site 298653010039 substrate binding pocket [chemical binding]; other site 298653010040 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653010041 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653010042 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 298653010043 CoenzymeA binding site [chemical binding]; other site 298653010044 subunit interaction site [polypeptide binding]; other site 298653010045 PHB binding site; other site 298653010046 Phosphopantetheine attachment site; Region: PP-binding; cl09936 298653010047 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 298653010048 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653010049 S-adenosylmethionine binding site [chemical binding]; other site 298653010050 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 298653010051 homodimer interface [polypeptide binding]; other site 298653010052 putative substrate binding pocket [chemical binding]; other site 298653010053 diiron center [ion binding]; other site 298653010054 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 298653010055 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 298653010056 oligomeric interface; other site 298653010057 putative active site [active] 298653010058 homodimer interface [polypeptide binding]; other site 298653010059 High-affinity nickel-transport protein; Region: NicO; cl00964 298653010060 Protein of unknown function N-terminus (DUF3323); Region: DUF3323; pfam11796 298653010061 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 298653010062 Flagellar FliJ protein; Region: FliJ; pfam02050 298653010063 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 298653010064 Protein of unknown function (DUF2398); Region: DUF2398; pfam09661 298653010065 TIGR02677 family protein; Region: TIGR02677 298653010066 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 298653010067 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 298653010068 Transposase; Region: DDE_Tnp_ISL3; pfam01610 298653010069 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 298653010070 TPR motif; other site 298653010071 binding surface 298653010072 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 298653010073 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653010074 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 298653010075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 298653010076 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 298653010077 MarR family; Region: MarR_2; pfam12802 298653010078 Possible enoyl reductase; Region: MDR_enoyl_red; cd08244 298653010079 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 298653010080 putative NAD(P) binding site [chemical binding]; other site 298653010081 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 298653010082 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 298653010083 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 298653010084 DNA binding residues [nucleotide binding] 298653010085 Putative zinc-finger; Region: zf-HC2; pfam13490 298653010086 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 298653010087 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653010088 Walker A/P-loop; other site 298653010089 ATP binding site [chemical binding]; other site 298653010090 Q-loop/lid; other site 298653010091 ABC transporter signature motif; other site 298653010092 Walker B; other site 298653010093 D-loop; other site 298653010094 H-loop/switch region; other site 298653010095 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 298653010096 Integrase core domain; Region: rve_3; pfam13683 298653010097 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 298653010098 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 298653010099 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 298653010100 iron-sulfur cluster [ion binding]; other site 298653010101 [2Fe-2S] cluster binding site [ion binding]; other site 298653010102 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653010103 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 298653010104 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 298653010105 putative hydrophobic ligand binding site [chemical binding]; other site 298653010106 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 298653010107 gas vesicle synthesis-like protein; Reviewed; Region: PRK09368 298653010108 Gas vesicle protein K; Region: GvpK; pfam05121 298653010109 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 298653010110 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 298653010111 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 298653010112 catalytic core [active] 298653010113 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 298653010114 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 298653010115 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 298653010116 active site 298653010117 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653010118 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653010119 DNA binding residues [nucleotide binding] 298653010120 dimerization interface [polypeptide binding]; other site 298653010121 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 298653010122 active site clefts [active] 298653010123 zinc binding site [ion binding]; other site 298653010124 dimer interface [polypeptide binding]; other site 298653010125 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653010126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653010127 NADH(P)-binding; Region: NAD_binding_10; pfam13460 298653010128 active site 298653010129 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 298653010130 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653010131 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 298653010132 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653010133 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653010134 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 298653010135 active site 298653010136 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653010137 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653010138 active site 298653010139 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 298653010140 putative active site [active] 298653010141 putative catalytic site [active] 298653010142 enoyl-CoA hydratase; Provisional; Region: PRK08252 298653010143 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653010144 substrate binding site [chemical binding]; other site 298653010145 oxyanion hole (OAH) forming residues; other site 298653010146 trimer interface [polypeptide binding]; other site 298653010147 Amidohydrolase; Region: Amidohydro_2; pfam04909 298653010148 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653010149 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653010150 NAD(P) binding site [chemical binding]; other site 298653010151 active site 298653010152 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 298653010153 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 298653010154 active site 298653010155 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 298653010156 catalytic triad [active] 298653010157 dimer interface [polypeptide binding]; other site 298653010158 putative acyltransferase; Provisional; Region: PRK05790 298653010159 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 298653010160 dimer interface [polypeptide binding]; other site 298653010161 active site 298653010162 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 298653010163 TM-ABC transporter signature motif; other site 298653010164 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 298653010165 TM-ABC transporter signature motif; other site 298653010166 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 298653010167 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 298653010168 Probable transposase; Region: OrfB_IS605; pfam01385 298653010169 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 298653010170 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 298653010171 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 298653010172 Walker A/P-loop; other site 298653010173 ATP binding site [chemical binding]; other site 298653010174 Q-loop/lid; other site 298653010175 ABC transporter signature motif; other site 298653010176 Walker B; other site 298653010177 D-loop; other site 298653010178 H-loop/switch region; other site 298653010179 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 298653010180 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 298653010181 Walker A/P-loop; other site 298653010182 ATP binding site [chemical binding]; other site 298653010183 Q-loop/lid; other site 298653010184 ABC transporter signature motif; other site 298653010185 Walker B; other site 298653010186 D-loop; other site 298653010187 H-loop/switch region; other site 298653010188 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 298653010189 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653010190 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653010191 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653010192 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653010193 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 298653010194 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 298653010195 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 298653010196 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 298653010197 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 298653010198 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 298653010199 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 298653010200 carboxyltransferase (CT) interaction site; other site 298653010201 biotinylation site [posttranslational modification]; other site 298653010202 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 298653010203 active site 298653010204 catalytic residues [active] 298653010205 metal binding site [ion binding]; metal-binding site 298653010206 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653010207 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653010208 active site 298653010209 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 298653010210 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 298653010211 NAD(P) binding site [chemical binding]; other site 298653010212 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653010213 ferredoxin-NADP+ reductase; Region: PLN02852 298653010214 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653010215 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653010216 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653010217 active site 298653010218 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 298653010219 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 298653010220 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 298653010221 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 298653010222 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 298653010223 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 298653010224 Walker A/P-loop; other site 298653010225 ATP binding site [chemical binding]; other site 298653010226 Q-loop/lid; other site 298653010227 ABC transporter signature motif; other site 298653010228 Walker B; other site 298653010229 D-loop; other site 298653010230 H-loop/switch region; other site 298653010231 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653010232 non-specific DNA binding site [nucleotide binding]; other site 298653010233 salt bridge; other site 298653010234 sequence-specific DNA binding site [nucleotide binding]; other site 298653010235 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 298653010236 E-class dimer interface [polypeptide binding]; other site 298653010237 P-class dimer interface [polypeptide binding]; other site 298653010238 active site 298653010239 Cu2+ binding site [ion binding]; other site 298653010240 Zn2+ binding site [ion binding]; other site 298653010241 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 298653010242 hypothetical protein; Provisional; Region: PRK07877 298653010243 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653010244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653010245 active site 298653010246 phosphorylation site [posttranslational modification] 298653010247 intermolecular recognition site; other site 298653010248 dimerization interface [polypeptide binding]; other site 298653010249 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653010250 DNA binding residues [nucleotide binding] 298653010251 dimerization interface [polypeptide binding]; other site 298653010252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 298653010253 AAA ATPase domain; Region: AAA_16; pfam13191 298653010254 AAA domain; Region: AAA_33; pfam13671 298653010255 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 298653010256 nudix motif; other site 298653010257 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 298653010258 nucleoside/Zn binding site; other site 298653010259 dimer interface [polypeptide binding]; other site 298653010260 catalytic motif [active] 298653010261 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 298653010262 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653010263 Walker A/P-loop; other site 298653010264 ATP binding site [chemical binding]; other site 298653010265 Q-loop/lid; other site 298653010266 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 298653010267 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653010268 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653010269 active site 298653010270 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 298653010271 dimer interface [polypeptide binding]; other site 298653010272 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 298653010273 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653010274 active site 298653010275 ATP binding site [chemical binding]; other site 298653010276 substrate binding site [chemical binding]; other site 298653010277 activation loop (A-loop); other site 298653010278 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 298653010279 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 298653010280 active site 298653010281 catalytic residues [active] 298653010282 metal binding site [ion binding]; metal-binding site 298653010283 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 298653010284 dinuclear metal binding motif [ion binding]; other site 298653010285 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 298653010286 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 298653010287 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 298653010288 DNA binding residues [nucleotide binding] 298653010289 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 298653010290 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 298653010291 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 298653010292 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 298653010293 catalytic residue [active] 298653010294 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 298653010295 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 298653010296 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 298653010297 putative active site [active] 298653010298 putative dimer interface [polypeptide binding]; other site 298653010299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653010300 Major Facilitator Superfamily; Region: MFS_1; pfam07690 298653010301 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653010302 salt bridge; other site 298653010303 non-specific DNA binding site [nucleotide binding]; other site 298653010304 sequence-specific DNA binding site [nucleotide binding]; other site 298653010305 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 298653010306 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 298653010307 MarR family; Region: MarR_2; pfam12802 298653010308 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 298653010309 NADH(P)-binding; Region: NAD_binding_10; pfam13460 298653010310 NAD binding site [chemical binding]; other site 298653010311 substrate binding site [chemical binding]; other site 298653010312 putative active site [active] 298653010313 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 298653010314 active site clefts [active] 298653010315 zinc binding site [ion binding]; other site 298653010316 dimer interface [polypeptide binding]; other site 298653010317 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653010318 active site 298653010319 ATP binding site [chemical binding]; other site 298653010320 substrate binding site [chemical binding]; other site 298653010321 activation loop (A-loop); other site 298653010322 NHL repeat; Region: NHL; pfam01436 298653010323 NHL repeat; Region: NHL; pfam01436 298653010324 NHL repeat; Region: NHL; pfam01436 298653010325 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653010326 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653010327 active site 298653010328 ATP binding site [chemical binding]; other site 298653010329 substrate binding site [chemical binding]; other site 298653010330 activation loop (A-loop); other site 298653010331 NHL repeat; Region: NHL; pfam01436 298653010332 NHL repeat; Region: NHL; pfam01436 298653010333 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653010334 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653010335 active site 298653010336 ATP binding site [chemical binding]; other site 298653010337 substrate binding site [chemical binding]; other site 298653010338 activation loop (A-loop); other site 298653010339 Clp amino terminal domain; Region: Clp_N; pfam02861 298653010340 Clp amino terminal domain; Region: Clp_N; pfam02861 298653010341 ABC-2 type transporter; Region: ABC2_membrane; cl11417 298653010342 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 298653010343 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653010344 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 298653010345 Walker A/P-loop; other site 298653010346 ATP binding site [chemical binding]; other site 298653010347 Q-loop/lid; other site 298653010348 ABC transporter signature motif; other site 298653010349 Walker B; other site 298653010350 D-loop; other site 298653010351 H-loop/switch region; other site 298653010352 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653010353 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653010354 Predicted acyl esterases [General function prediction only]; Region: COG2936 298653010355 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653010356 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 298653010357 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653010358 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 298653010359 Nitroreductase family; Region: Nitroreductase; pfam00881 298653010360 FMN binding site [chemical binding]; other site 298653010361 dimer interface [polypeptide binding]; other site 298653010362 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 298653010363 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 298653010364 Bacterial transcriptional regulator; Region: IclR; pfam01614 298653010365 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 298653010366 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 298653010367 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 298653010368 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 298653010369 active site 298653010370 non-prolyl cis peptide bond; other site 298653010371 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 298653010372 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 298653010373 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 298653010374 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; pfam02826 298653010375 SnoaL-like domain; Region: SnoaL_4; pfam13577 298653010376 GAF domain; Region: GAF; pfam01590 298653010377 GAF domain; Region: GAF_2; pfam13185 298653010378 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 298653010379 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 298653010380 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 298653010381 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 298653010382 dimerization interface [polypeptide binding]; other site 298653010383 putative DNA binding site [nucleotide binding]; other site 298653010384 putative Zn2+ binding site [ion binding]; other site 298653010385 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 298653010386 putative hydrophobic ligand binding site [chemical binding]; other site 298653010387 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653010388 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653010389 NAD(P) binding site [chemical binding]; other site 298653010390 active site 298653010391 putative transporter; Provisional; Region: PRK10504 298653010392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653010393 putative substrate translocation pore; other site 298653010394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653010395 Predicted transcriptional regulators [Transcription]; Region: COG1733 298653010396 putative DNA binding site [nucleotide binding]; other site 298653010397 putative Zn2+ binding site [ion binding]; other site 298653010398 dimerization interface [polypeptide binding]; other site 298653010399 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653010400 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653010401 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 298653010402 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653010403 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653010404 Major Facilitator Superfamily; Region: MFS_1; pfam07690 298653010405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653010406 Dienelactone hydrolase family; Region: DLH; pfam01738 298653010407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 298653010408 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 298653010409 uridine kinase; Validated; Region: PRK06696 298653010410 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653010411 active site 298653010412 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 298653010413 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such...; Region: APH_ChoK_like_1; cd05155 298653010414 putative active site [active] 298653010415 putative substrate binding site [chemical binding]; other site 298653010416 ATP binding site [chemical binding]; other site 298653010417 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 298653010418 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 298653010419 Methyltransferase domain; Region: Methyltransf_11; pfam08241 298653010420 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 298653010421 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 298653010422 Coenzyme A binding pocket [chemical binding]; other site 298653010423 hypothetical protein; Provisional; Region: PRK06834 298653010424 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653010425 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 298653010426 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 298653010427 HicB family; Region: HicB; pfam05534 298653010428 amidase; Provisional; Region: PRK06170 298653010429 Amidase; Region: Amidase; pfam01425 298653010430 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653010431 Methyltransferase domain; Region: Methyltransf_23; pfam13489 298653010432 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653010433 S-adenosylmethionine binding site [chemical binding]; other site 298653010434 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 298653010435 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 298653010436 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 298653010437 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 298653010438 Transposase [DNA replication, recombination, and repair]; Region: COG5421 298653010439 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 298653010440 Epoxide hydrolase N terminus; Region: EHN; pfam06441 298653010441 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653010442 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653010443 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 298653010444 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 298653010445 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 298653010446 Coenzyme A binding pocket [chemical binding]; other site 298653010447 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 298653010448 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 298653010449 DNA binding site [nucleotide binding] 298653010450 dimer interface [polypeptide binding]; other site 298653010451 active site 298653010452 Int/Topo IB signature motif; other site 298653010453 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 298653010454 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653010455 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 298653010456 metal ion-dependent adhesion site (MIDAS); other site 298653010457 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 298653010458 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 298653010459 Walker A motif; other site 298653010460 ATP binding site [chemical binding]; other site 298653010461 Walker B motif; other site 298653010462 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 298653010463 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 298653010464 catalytic triad [active] 298653010465 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 298653010466 homodimer interface [polypeptide binding]; other site 298653010467 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 298653010468 active site 298653010469 SAM binding site [chemical binding]; other site 298653010470 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 298653010471 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 298653010472 active site 298653010473 SAM binding site [chemical binding]; other site 298653010474 homodimer interface [polypeptide binding]; other site 298653010475 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 298653010476 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 298653010477 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 298653010478 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 298653010479 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 298653010480 active site 298653010481 SAM binding site [chemical binding]; other site 298653010482 homodimer interface [polypeptide binding]; other site 298653010483 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 298653010484 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 298653010485 putative active site [active] 298653010486 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 298653010487 putative active site [active] 298653010488 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 298653010489 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 298653010490 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 298653010491 putative acyl-acceptor binding pocket; other site 298653010492 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 298653010493 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 298653010494 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 298653010495 NAD(P) binding site [chemical binding]; other site 298653010496 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653010497 active site 298653010498 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653010499 active site 298653010500 C-terminal domain of fatty acyl CoA reductases; Region: FAR_C; cd09071 298653010501 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 298653010502 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 298653010503 5'-3' exonuclease; Region: 53EXOc; smart00475 298653010504 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 298653010505 active site 298653010506 metal binding site 1 [ion binding]; metal-binding site 298653010507 putative 5' ssDNA interaction site; other site 298653010508 metal binding site 3; metal-binding site 298653010509 metal binding site 2 [ion binding]; metal-binding site 298653010510 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 298653010511 putative DNA binding site [nucleotide binding]; other site 298653010512 putative metal binding site [ion binding]; other site 298653010513 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 298653010514 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 298653010515 putative DNA binding site [nucleotide binding]; other site 298653010516 putative Zn2+ binding site [ion binding]; other site 298653010517 AsnC family; Region: AsnC_trans_reg; pfam01037 298653010518 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 298653010519 active site 298653010520 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 298653010521 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 298653010522 putative active site [active] 298653010523 catalytic triad [active] 298653010524 putative dimer interface [polypeptide binding]; other site 298653010525 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 298653010526 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 298653010527 Ligand binding site; other site 298653010528 Putative Catalytic site; other site 298653010529 DXD motif; other site 298653010530 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 298653010531 methionine sulfoxide reductase B; Provisional; Region: PRK00222 298653010532 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 298653010533 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 298653010534 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 298653010535 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 298653010536 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 298653010537 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 298653010538 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653010539 Walker A/P-loop; other site 298653010540 ATP binding site [chemical binding]; other site 298653010541 Q-loop/lid; other site 298653010542 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 298653010543 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653010544 Walker A/P-loop; other site 298653010545 ATP binding site [chemical binding]; other site 298653010546 Q-loop/lid; other site 298653010547 ABC transporter signature motif; other site 298653010548 Walker B; other site 298653010549 D-loop; other site 298653010550 H-loop/switch region; other site 298653010551 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 298653010552 Spore germination protein; Region: Spore_permease; cl15802 298653010553 tetracycline repressor protein TetR; Provisional; Region: PRK13756 298653010554 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653010555 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 298653010556 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 298653010557 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 298653010558 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653010559 NAD(P) binding pocket [chemical binding]; other site 298653010560 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653010561 metal binding site [ion binding]; metal-binding site 298653010562 active site 298653010563 I-site; other site 298653010564 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 298653010565 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 298653010566 inhibitor-cofactor binding pocket; inhibition site 298653010567 pyridoxal 5'-phosphate binding site [chemical binding]; other site 298653010568 catalytic residue [active] 298653010569 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 298653010570 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653010571 substrate binding site [chemical binding]; other site 298653010572 oxyanion hole (OAH) forming residues; other site 298653010573 trimer interface [polypeptide binding]; other site 298653010574 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 298653010575 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 298653010576 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 298653010577 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 298653010578 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 298653010579 Part of AAA domain; Region: AAA_19; pfam13245 298653010580 Family description; Region: UvrD_C_2; pfam13538 298653010581 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 298653010582 Fatty acid desaturase; Region: FA_desaturase; pfam00487 298653010583 Di-iron ligands [ion binding]; other site 298653010584 DEAD-like helicases superfamily; Region: DEXDc; smart00487 298653010585 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 298653010586 ATP binding site [chemical binding]; other site 298653010587 putative Mg++ binding site [ion binding]; other site 298653010588 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 298653010589 nucleotide binding region [chemical binding]; other site 298653010590 ATP-binding site [chemical binding]; other site 298653010591 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 298653010592 GAF domain; Region: GAF; pfam01590 298653010593 GAF domain; Region: GAF_2; pfam13185 298653010594 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653010595 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653010596 DNA binding residues [nucleotide binding] 298653010597 dimerization interface [polypeptide binding]; other site 298653010598 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 298653010599 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 298653010600 active site 298653010601 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 298653010602 catalytic triad [active] 298653010603 dimer interface [polypeptide binding]; other site 298653010604 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 298653010605 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 298653010606 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 298653010607 active site 298653010608 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653010609 metal binding site [ion binding]; metal-binding site 298653010610 active site 298653010611 I-site; other site 298653010612 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 298653010613 DNA-binding site [nucleotide binding]; DNA binding site 298653010614 RNA-binding motif; other site 298653010615 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653010616 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 298653010617 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 298653010618 active site 298653010619 FMN binding site [chemical binding]; other site 298653010620 substrate binding site [chemical binding]; other site 298653010621 3Fe-4S cluster binding site [ion binding]; other site 298653010622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653010623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653010624 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 298653010625 MarR family; Region: MarR; pfam01047 298653010626 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653010627 S-adenosylmethionine binding site [chemical binding]; other site 298653010628 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 298653010629 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 298653010630 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 298653010631 DNA binding residues [nucleotide binding] 298653010632 Anti-sigma-K factor rskA; Region: RskA; pfam10099 298653010633 PAS fold; Region: PAS; pfam00989 298653010634 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 298653010635 putative active site [active] 298653010636 heme pocket [chemical binding]; other site 298653010637 GAF domain; Region: GAF; cl15785 298653010638 Histidine kinase; Region: HisKA_3; pfam07730 298653010639 hypothetical protein; Provisional; Region: PRK09266 298653010640 homodimer interface [polypeptide binding]; other site 298653010641 substrate-cofactor binding pocket; other site 298653010642 pyridoxal 5'-phosphate binding site [chemical binding]; other site 298653010643 catalytic residue [active] 298653010644 hypothetical protein; Provisional; Region: PRK04194 298653010645 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 298653010646 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 298653010647 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 298653010648 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 298653010649 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 298653010650 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653010651 Transcriptional regulators [Transcription]; Region: PurR; COG1609 298653010652 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 298653010653 DNA binding site [nucleotide binding] 298653010654 domain linker motif; other site 298653010655 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 298653010656 dimerization interface [polypeptide binding]; other site 298653010657 ligand binding site [chemical binding]; other site 298653010658 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653010659 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 298653010660 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 298653010661 Transcriptional regulator [Transcription]; Region: IclR; COG1414 298653010662 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 298653010663 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 298653010664 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 298653010665 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653010666 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 298653010667 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 298653010668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 298653010669 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 298653010670 active site 298653010671 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 298653010672 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 298653010673 CysD dimerization site [polypeptide binding]; other site 298653010674 G1 box; other site 298653010675 putative GEF interaction site [polypeptide binding]; other site 298653010676 GTP/Mg2+ binding site [chemical binding]; other site 298653010677 Switch I region; other site 298653010678 G2 box; other site 298653010679 G3 box; other site 298653010680 Switch II region; other site 298653010681 G4 box; other site 298653010682 G5 box; other site 298653010683 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 298653010684 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 298653010685 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 298653010686 ligand-binding site [chemical binding]; other site 298653010687 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 298653010688 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 298653010689 Active Sites [active] 298653010690 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 298653010691 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 298653010692 NAD(P) binding site [chemical binding]; other site 298653010693 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 298653010694 Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945 298653010695 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 298653010696 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653010697 classical (c) SDRs; Region: SDR_c; cd05233 298653010698 NAD(P) binding site [chemical binding]; other site 298653010699 active site 298653010700 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 298653010701 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 298653010702 active site 298653010703 catalytic tetrad [active] 298653010704 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 298653010705 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 298653010706 P-loop; other site 298653010707 Magnesium ion binding site [ion binding]; other site 298653010708 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 298653010709 Magnesium ion binding site [ion binding]; other site 298653010710 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 298653010711 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 298653010712 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 298653010713 putative DNA binding site [nucleotide binding]; other site 298653010714 putative Zn2+ binding site [ion binding]; other site 298653010715 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 298653010716 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 298653010717 metal binding site [ion binding]; metal-binding site 298653010718 Amidase; Region: Amidase; cl11426 298653010719 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 298653010720 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 298653010721 MarR family; Region: MarR; pfam01047 298653010722 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 298653010723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653010724 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 298653010725 Histidine kinase; Region: HisKA_3; pfam07730 298653010726 TIR domain; Region: TIR_2; pfam13676 298653010727 FOG: WD40 repeat [General function prediction only]; Region: COG2319 298653010728 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 298653010729 structural tetrad; other site 298653010730 FOG: WD40 repeat [General function prediction only]; Region: COG2319 298653010731 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 298653010732 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 298653010733 Protein of unknown function DUF58; Region: DUF58; pfam01882 298653010734 MoxR-like ATPases [General function prediction only]; Region: COG0714 298653010735 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 298653010736 Walker A motif; other site 298653010737 ATP binding site [chemical binding]; other site 298653010738 Walker B motif; other site 298653010739 arginine finger; other site 298653010740 Bacterial SH3 domain; Region: SH3_3; cl17532 298653010741 TIR domain; Region: TIR_2; pfam13676 298653010742 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653010743 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653010744 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653010745 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653010746 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653010747 TIR domain; Region: TIR_2; pfam13676 298653010748 AAA ATPase domain; Region: AAA_16; pfam13191 298653010749 FOG: WD40 repeat [General function prediction only]; Region: COG2319 298653010750 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 298653010751 structural tetrad; other site 298653010752 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 298653010753 FOG: WD40 repeat [General function prediction only]; Region: COG2319 298653010754 structural tetrad; other site 298653010755 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 298653010756 nudix motif; other site 298653010757 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 298653010758 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 298653010759 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 298653010760 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 298653010761 homodimer interface [polypeptide binding]; other site 298653010762 substrate-cofactor binding pocket; other site 298653010763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 298653010764 catalytic residue [active] 298653010765 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 298653010766 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 298653010767 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 298653010768 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 298653010769 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 298653010770 homodimer interface [polypeptide binding]; other site 298653010771 substrate-cofactor binding pocket; other site 298653010772 pyridoxal 5'-phosphate binding site [chemical binding]; other site 298653010773 catalytic residue [active] 298653010774 Domain of unknown function (DUF222); Region: DUF222; pfam02720 298653010775 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 298653010776 active site 298653010777 TIR domain; Region: TIR_2; pfam13676 298653010778 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 298653010779 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653010780 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653010781 active site 298653010782 ATP binding site [chemical binding]; other site 298653010783 substrate binding site [chemical binding]; other site 298653010784 activation loop (A-loop); other site 298653010785 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 298653010786 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653010787 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 298653010788 active site 298653010789 substrate binding site [chemical binding]; other site 298653010790 ATP binding site [chemical binding]; other site 298653010791 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 298653010792 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 298653010793 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 298653010794 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 298653010795 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 298653010796 active site 298653010797 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 298653010798 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 298653010799 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 298653010800 NADP binding site [chemical binding]; other site 298653010801 active site 298653010802 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 298653010803 Thioesterase; Region: PKS_TE; smart00824 298653010804 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 298653010805 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653010806 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 298653010807 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 298653010808 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 298653010809 [2Fe-2S] cluster binding site [ion binding]; other site 298653010810 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 298653010811 putative alpha subunit interface [polypeptide binding]; other site 298653010812 putative active site [active] 298653010813 putative substrate binding site [chemical binding]; other site 298653010814 Fe binding site [ion binding]; other site 298653010815 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 298653010816 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 298653010817 FAD binding pocket [chemical binding]; other site 298653010818 FAD binding motif [chemical binding]; other site 298653010819 phosphate binding motif [ion binding]; other site 298653010820 NAD binding pocket [chemical binding]; other site 298653010821 Proline dehydrogenase; Region: Pro_dh; cl03282 298653010822 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 298653010823 NAD(P) binding site [chemical binding]; other site 298653010824 catalytic residues [active] 298653010825 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 298653010826 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 298653010827 active site 298653010828 metal binding site [ion binding]; metal-binding site 298653010829 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 298653010830 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 298653010831 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 298653010832 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 298653010833 putative substrate binding site [chemical binding]; other site 298653010834 active site 298653010835 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 298653010836 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 298653010837 DNA binding residues [nucleotide binding] 298653010838 putative dimer interface [polypeptide binding]; other site 298653010839 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 298653010840 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 298653010841 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653010842 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653010843 active site 298653010844 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 298653010845 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 298653010846 NAD(P) binding site [chemical binding]; other site 298653010847 catalytic residues [active] 298653010848 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 298653010849 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 298653010850 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653010851 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 298653010852 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 298653010853 [2Fe-2S] cluster binding site [ion binding]; other site 298653010854 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 298653010855 alpha subunit interface [polypeptide binding]; other site 298653010856 active site 298653010857 substrate binding site [chemical binding]; other site 298653010858 Fe binding site [ion binding]; other site 298653010859 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 298653010860 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 298653010861 active site 298653010862 SnoaL-like domain; Region: SnoaL_4; pfam13577 298653010863 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653010864 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653010865 active site 298653010866 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653010867 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653010868 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653010869 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653010870 enoyl-CoA hydratase; Provisional; Region: PRK08290 298653010871 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653010872 substrate binding site [chemical binding]; other site 298653010873 oxyanion hole (OAH) forming residues; other site 298653010874 trimer interface [polypeptide binding]; other site 298653010875 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653010876 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653010877 active site 298653010878 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653010879 active site 298653010880 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653010881 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653010882 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653010883 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 298653010884 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653010885 NAD(P) binding site [chemical binding]; other site 298653010886 active site 298653010887 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653010888 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653010889 active site 298653010890 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653010891 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 298653010892 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653010893 Domain of unknown function (DUF4009); Region: DUF4009; pfam13193 298653010894 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 298653010895 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 298653010896 FAD binding pocket [chemical binding]; other site 298653010897 FAD binding motif [chemical binding]; other site 298653010898 phosphate binding motif [ion binding]; other site 298653010899 beta-alpha-beta structure motif; other site 298653010900 NAD(p) ribose binding residues [chemical binding]; other site 298653010901 NAD binding pocket [chemical binding]; other site 298653010902 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 298653010903 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 298653010904 catalytic loop [active] 298653010905 iron binding site [ion binding]; other site 298653010906 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653010907 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653010908 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 298653010909 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653010910 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 298653010911 B12 binding site [chemical binding]; other site 298653010912 cobalt ligand [ion binding]; other site 298653010913 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 298653010914 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884 298653010915 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 298653010916 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653010917 Domain of unknown function (DUF4009); Region: DUF4009; pfam13193 298653010918 Amidohydrolase; Region: Amidohydro_2; pfam04909 298653010919 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 298653010920 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653010921 Domain of unknown function (DUF4009); Region: DUF4009; pfam13193 298653010922 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 298653010923 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653010924 substrate binding site [chemical binding]; other site 298653010925 oxyanion hole (OAH) forming residues; other site 298653010926 trimer interface [polypeptide binding]; other site 298653010927 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653010928 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653010929 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 298653010930 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 298653010931 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653010932 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653010933 NAD(P) binding site [chemical binding]; other site 298653010934 active site 298653010935 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 298653010936 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653010937 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653010938 NAD(P) binding site [chemical binding]; other site 298653010939 active site 298653010940 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653010941 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653010942 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 298653010943 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653010944 NAD(P) binding site [chemical binding]; other site 298653010945 active site 298653010946 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 298653010947 CoenzymeA binding site [chemical binding]; other site 298653010948 subunit interaction site [polypeptide binding]; other site 298653010949 PHB binding site; other site 298653010950 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 298653010951 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 298653010952 DUF35 OB-fold domain; Region: DUF35; pfam01796 298653010953 lipid-transfer protein; Provisional; Region: PRK07855 298653010954 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 298653010955 active site 298653010956 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653010957 YCII-related domain; Region: YCII; cl00999 298653010958 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 298653010959 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 298653010960 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 298653010961 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 298653010962 classical (c) SDRs; Region: SDR_c; cd05233 298653010963 NAD(P) binding site [chemical binding]; other site 298653010964 active site 298653010965 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653010966 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 298653010967 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 298653010968 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653010969 active site 298653010970 phosphorylation site [posttranslational modification] 298653010971 intermolecular recognition site; other site 298653010972 dimerization interface [polypeptide binding]; other site 298653010973 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 298653010974 DNA binding site [nucleotide binding] 298653010975 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 298653010976 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 298653010977 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653010978 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653010979 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653010980 active site 298653010981 phosphorylation site [posttranslational modification] 298653010982 intermolecular recognition site; other site 298653010983 dimerization interface [polypeptide binding]; other site 298653010984 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 298653010985 dimerization interface [polypeptide binding]; other site 298653010986 DNA binding residues [nucleotide binding] 298653010987 2TM domain; Region: 2TM; pfam13239 298653010988 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 298653010989 Histidine kinase; Region: HisKA_3; pfam07730 298653010990 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653010991 ATP binding site [chemical binding]; other site 298653010992 Mg2+ binding site [ion binding]; other site 298653010993 G-X-G motif; other site 298653010994 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 298653010995 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 298653010996 Glutamate-cysteine ligase; Region: GCS; pfam03074 298653010997 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 298653010998 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 298653010999 Walker A/P-loop; other site 298653011000 ATP binding site [chemical binding]; other site 298653011001 Q-loop/lid; other site 298653011002 ABC transporter signature motif; other site 298653011003 Walker B; other site 298653011004 D-loop; other site 298653011005 H-loop/switch region; other site 298653011006 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 298653011007 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653011008 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653011009 short chain dehydrogenase; Provisional; Region: PRK06940 298653011010 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653011011 NAD(P) binding site [chemical binding]; other site 298653011012 active site 298653011013 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 298653011014 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 298653011015 active site 298653011016 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 298653011017 iron-sulfur cluster [ion binding]; other site 298653011018 [2Fe-2S] cluster binding site [ion binding]; other site 298653011019 AAA ATPase domain; Region: AAA_16; pfam13191 298653011020 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653011021 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653011022 DNA binding residues [nucleotide binding] 298653011023 dimerization interface [polypeptide binding]; other site 298653011024 Protein of unknown function (DUF692); Region: DUF692; cl01263 298653011025 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349; Region: Frankia_peptide; pfam14407 298653011026 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 298653011027 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 298653011028 putative substrate binding region [chemical binding]; other site 298653011029 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 298653011030 ligand binding site [chemical binding]; other site 298653011031 flexible hinge region; other site 298653011032 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 298653011033 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 298653011034 ligand binding site [chemical binding]; other site 298653011035 flexible hinge region; other site 298653011036 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 298653011037 putative catalytic residues [active] 298653011038 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653011039 NAD(P) binding site [chemical binding]; other site 298653011040 active site 298653011041 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 298653011042 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 298653011043 conserved cys residue [active] 298653011044 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 298653011045 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 298653011046 [2Fe-2S] cluster binding site [ion binding]; other site 298653011047 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 298653011048 alpha subunit interface [polypeptide binding]; other site 298653011049 active site 298653011050 substrate binding site [chemical binding]; other site 298653011051 Fe binding site [ion binding]; other site 298653011052 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 298653011053 Sulfatase; Region: Sulfatase; cl10460 298653011054 Sulfatase; Region: Sulfatase; cl10460 298653011055 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653011056 substrate binding site [chemical binding]; other site 298653011057 activation loop (A-loop); other site 298653011058 AAA ATPase domain; Region: AAA_16; pfam13191 298653011059 Predicted ATPase [General function prediction only]; Region: COG3899 298653011060 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 298653011061 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 298653011062 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653011063 metal binding site [ion binding]; metal-binding site 298653011064 active site 298653011065 I-site; other site 298653011066 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 298653011067 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 298653011068 putative active site [active] 298653011069 putative NTP binding site [chemical binding]; other site 298653011070 putative nucleic acid binding site [nucleotide binding]; other site 298653011071 Type II intron maturase; Region: Intron_maturas2; pfam01348 298653011072 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 298653011073 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 298653011074 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 298653011075 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 298653011076 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 298653011077 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 298653011078 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 298653011079 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 298653011080 Integrase core domain; Region: rve_3; cl15866 298653011081 Integrase core domain; Region: rve; pfam00665 298653011082 Integrase core domain; Region: rve_3; cl15866 298653011083 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 298653011084 putative active site [active] 298653011085 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 298653011086 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 298653011087 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 298653011088 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 298653011089 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 298653011090 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 298653011091 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 298653011092 DNA binding residues [nucleotide binding] 298653011093 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 298653011094 dimerization interface [polypeptide binding]; other site 298653011095 putative DNA binding site [nucleotide binding]; other site 298653011096 putative Zn2+ binding site [ion binding]; other site 298653011097 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 298653011098 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 298653011099 active site 298653011100 substrate-binding site [chemical binding]; other site 298653011101 metal-binding site [ion binding] 298653011102 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 298653011103 dimerization interface [polypeptide binding]; other site 298653011104 putative DNA binding site [nucleotide binding]; other site 298653011105 putative Zn2+ binding site [ion binding]; other site 298653011106 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 298653011107 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 298653011108 DNA binding residues [nucleotide binding] 298653011109 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 298653011110 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 298653011111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653011112 ATP binding site [chemical binding]; other site 298653011113 Mg2+ binding site [ion binding]; other site 298653011114 G-X-G motif; other site 298653011115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653011116 Response regulator receiver domain; Region: Response_reg; pfam00072 298653011117 active site 298653011118 phosphorylation site [posttranslational modification] 298653011119 intermolecular recognition site; other site 298653011120 dimerization interface [polypeptide binding]; other site 298653011121 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653011122 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 298653011123 Integrase core domain; Region: rve_3; cl15866 298653011124 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 298653011125 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 298653011126 UbiA prenyltransferase family; Region: UbiA; pfam01040 298653011127 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 298653011128 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653011129 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653011130 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 298653011131 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 298653011132 active site 298653011133 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 298653011134 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 298653011135 malonyl-CoA binding site [chemical binding]; other site 298653011136 dimer interface [polypeptide binding]; other site 298653011137 active site 298653011138 product binding site; other site 298653011139 Integrase core domain; Region: rve; pfam00665 298653011140 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 298653011141 YibE/F-like protein; Region: YibE_F; pfam07907 298653011142 Integrase core domain; Region: rve; pfam00665 298653011143 Integrase core domain; Region: rve_3; pfam13683 298653011144 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 298653011145 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 298653011146 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 298653011147 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 298653011148 PAS domain; Region: PAS; smart00091 298653011149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653011150 ATP binding site [chemical binding]; other site 298653011151 Mg2+ binding site [ion binding]; other site 298653011152 G-X-G motif; other site 298653011153 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 298653011154 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653011155 active site 298653011156 phosphorylation site [posttranslational modification] 298653011157 intermolecular recognition site; other site 298653011158 dimerization interface [polypeptide binding]; other site 298653011159 DDE superfamily endonuclease; Region: DDE_5; cl02413 298653011160 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 298653011161 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 298653011162 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 298653011163 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 298653011164 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 298653011165 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 298653011166 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 298653011167 active site 298653011168 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 298653011169 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 298653011170 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 298653011171 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 298653011172 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 298653011173 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653011174 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653011175 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 298653011176 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 298653011177 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653011178 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653011179 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 298653011180 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 298653011181 Mg++ binding site [ion binding]; other site 298653011182 putative catalytic motif [active] 298653011183 putative substrate binding site [chemical binding]; other site 298653011184 HTH-like domain; Region: HTH_21; pfam13276 298653011185 DDE superfamily endonuclease; Region: DDE_3; pfam13358 298653011186 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 298653011187 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 298653011188 Homeodomain-like domain; Region: HTH_32; pfam13565 298653011189 Winged helix-turn helix; Region: HTH_33; pfam13592 298653011190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653011191 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653011192 NAD(P) binding site [chemical binding]; other site 298653011193 active site 298653011194 AMP-binding enzyme; Region: AMP-binding; cl15778 298653011195 Helix-turn-helix domain; Region: HTH_38; pfam13936 298653011196 Winged helix-turn helix; Region: HTH_29; pfam13551 298653011197 DNA-binding interface [nucleotide binding]; DNA binding site 298653011198 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 298653011199 Integrase core domain; Region: rve; pfam00665 298653011200 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 298653011201 PAS fold; Region: PAS_4; pfam08448 298653011202 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653011203 metal binding site [ion binding]; metal-binding site 298653011204 active site 298653011205 I-site; other site 298653011206 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653011207 active site 298653011208 I-site; other site 298653011209 metal binding site [ion binding]; metal-binding site 298653011210 Integrase core domain; Region: rve; pfam00665 298653011211 DDE domain; Region: DDE_Tnp_IS240; pfam13610 298653011212 short chain dehydrogenase; Provisional; Region: PRK12828 298653011213 classical (c) SDRs; Region: SDR_c; cd05233 298653011214 NAD(P) binding site [chemical binding]; other site 298653011215 active site 298653011216 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653011217 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653011218 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 298653011219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653011220 putative PBP binding loops; other site 298653011221 dimer interface [polypeptide binding]; other site 298653011222 ABC-ATPase subunit interface; other site 298653011223 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 298653011224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653011225 dimer interface [polypeptide binding]; other site 298653011226 conserved gate region; other site 298653011227 putative PBP binding loops; other site 298653011228 ABC-ATPase subunit interface; other site 298653011229 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 298653011230 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653011231 Walker A/P-loop; other site 298653011232 ATP binding site [chemical binding]; other site 298653011233 Q-loop/lid; other site 298653011234 ABC transporter signature motif; other site 298653011235 Walker B; other site 298653011236 D-loop; other site 298653011237 H-loop/switch region; other site 298653011238 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 298653011239 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 298653011240 Amidohydrolase; Region: Amidohydro_2; pfam04909 298653011241 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 298653011242 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 298653011243 NAD binding site [chemical binding]; other site 298653011244 catalytic residues [active] 298653011245 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 298653011246 classical (c) SDRs; Region: SDR_c; cd05233 298653011247 NAD(P) binding site [chemical binding]; other site 298653011248 active site 298653011249 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653011250 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653011251 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 298653011252 classical (c) SDRs; Region: SDR_c; cd05233 298653011253 NAD(P) binding site [chemical binding]; other site 298653011254 active site 298653011255 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 298653011256 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653011257 substrate binding site [chemical binding]; other site 298653011258 oxyanion hole (OAH) forming residues; other site 298653011259 trimer interface [polypeptide binding]; other site 298653011260 Homeodomain-like domain; Region: HTH_23; pfam13384 298653011261 Winged helix-turn helix; Region: HTH_29; pfam13551 298653011262 Homeodomain-like domain; Region: HTH_32; pfam13565 298653011263 DDE superfamily endonuclease; Region: DDE_3; pfam13358 298653011264 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 298653011265 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 298653011266 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 298653011267 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 298653011268 Integrase core domain; Region: rve; pfam00665 298653011269 Integrase core domain; Region: rve_3; pfam13683 298653011270 Integrase core domain; Region: rve_3; pfam13683 298653011271 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 298653011272 Helix-turn-helix domain; Region: HTH_38; pfam13936 298653011273 Integrase core domain; Region: rve; pfam00665 298653011274 HTH-like domain; Region: HTH_21; pfam13276 298653011275 Integrase core domain; Region: rve; pfam00665 298653011276 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 298653011277 Transposase; Region: HTH_Tnp_1; pfam01527 298653011278 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653011279 Walker A/P-loop; other site 298653011280 ATP binding site [chemical binding]; other site 298653011281 Q-loop/lid; other site 298653011282 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653011283 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 298653011284 putative ligand binding site [chemical binding]; other site 298653011285 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 298653011286 classical (c) SDRs; Region: SDR_c; cd05233 298653011287 NAD(P) binding site [chemical binding]; other site 298653011288 active site 298653011289 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 298653011290 classical (c) SDRs; Region: SDR_c; cd05233 298653011291 NAD(P) binding site [chemical binding]; other site 298653011292 active site 298653011293 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653011294 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653011295 classical (c) SDRs; Region: SDR_c; cd05233 298653011296 NAD(P) binding site [chemical binding]; other site 298653011297 active site 298653011298 short chain dehydrogenase; Provisional; Region: PRK07774 298653011299 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 298653011300 NAD binding site [chemical binding]; other site 298653011301 homodimer interface [polypeptide binding]; other site 298653011302 active site 298653011303 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 298653011304 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653011305 Domain of unknown function (DUF4009); Region: DUF4009; pfam13193 298653011306 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 298653011307 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 298653011308 active site 298653011309 catalytic tetrad [active] 298653011310 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653011311 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653011312 NAD(P) binding site [chemical binding]; other site 298653011313 active site 298653011314 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 298653011315 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 298653011316 Walker A/P-loop; other site 298653011317 ATP binding site [chemical binding]; other site 298653011318 Q-loop/lid; other site 298653011319 ABC transporter signature motif; other site 298653011320 Walker B; other site 298653011321 D-loop; other site 298653011322 H-loop/switch region; other site 298653011323 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 298653011324 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 298653011325 Walker A/P-loop; other site 298653011326 ATP binding site [chemical binding]; other site 298653011327 Q-loop/lid; other site 298653011328 ABC transporter signature motif; other site 298653011329 Walker B; other site 298653011330 D-loop; other site 298653011331 H-loop/switch region; other site 298653011332 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 298653011333 TM-ABC transporter signature motif; other site 298653011334 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 298653011335 TM-ABC transporter signature motif; other site 298653011336 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 298653011337 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653011338 enoyl-CoA hydratase; Provisional; Region: PRK08260 298653011339 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653011340 substrate binding site [chemical binding]; other site 298653011341 oxyanion hole (OAH) forming residues; other site 298653011342 trimer interface [polypeptide binding]; other site 298653011343 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 298653011344 classical (c) SDRs; Region: SDR_c; cd05233 298653011345 NAD(P) binding site [chemical binding]; other site 298653011346 active site 298653011347 EthD domain; Region: EthD; pfam07110 298653011348 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653011349 lipid-transfer protein; Provisional; Region: PRK07855 298653011350 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 298653011351 active site 298653011352 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 298653011353 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 298653011354 DUF35 OB-fold domain; Region: DUF35; pfam01796 298653011355 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 298653011356 hydrophobic ligand binding site; other site 298653011357 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653011358 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653011359 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653011360 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653011361 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653011362 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653011363 active site 298653011364 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 298653011365 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 298653011366 putative active site [active] 298653011367 putative substrate binding site [chemical binding]; other site 298653011368 ATP binding site [chemical binding]; other site 298653011369 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 298653011370 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 298653011371 dimer interface [polypeptide binding]; other site 298653011372 active site 298653011373 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 298653011374 putative active site [active] 298653011375 putative catalytic site [active] 298653011376 PAS fold; Region: PAS_4; pfam08448 298653011377 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653011378 metal binding site [ion binding]; metal-binding site 298653011379 active site 298653011380 I-site; other site 298653011381 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 298653011382 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 298653011383 catalytic tetrad [active] 298653011384 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653011385 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653011386 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 298653011387 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653011388 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 298653011389 heterotetramer interface [polypeptide binding]; other site 298653011390 active site pocket [active] 298653011391 cleavage site 298653011392 Transposase; Region: DEDD_Tnp_IS110; pfam01548 298653011393 PAS domain S-box; Region: sensory_box; TIGR00229 298653011394 PAS domain S-box; Region: sensory_box; TIGR00229 298653011395 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653011396 metal binding site [ion binding]; metal-binding site 298653011397 active site 298653011398 I-site; other site 298653011399 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 298653011400 Transposase; Region: DDE_Tnp_ISL3; pfam01610 298653011401 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653011402 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653011403 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653011404 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 298653011405 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 298653011406 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 298653011407 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 298653011408 NAD(P) binding site [chemical binding]; other site 298653011409 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 298653011410 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 298653011411 NAD binding site [chemical binding]; other site 298653011412 catalytic residues [active] 298653011413 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 298653011414 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 298653011415 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653011416 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653011417 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 298653011418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653011419 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 298653011420 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 298653011421 catalytic core [active] 298653011422 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 298653011423 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653011424 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653011425 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 298653011426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653011427 dimer interface [polypeptide binding]; other site 298653011428 conserved gate region; other site 298653011429 putative PBP binding loops; other site 298653011430 ABC-ATPase subunit interface; other site 298653011431 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 298653011432 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 298653011433 Walker A/P-loop; other site 298653011434 ATP binding site [chemical binding]; other site 298653011435 Q-loop/lid; other site 298653011436 ABC transporter signature motif; other site 298653011437 Walker B; other site 298653011438 D-loop; other site 298653011439 H-loop/switch region; other site 298653011440 NMT1-like family; Region: NMT1_2; cl15260 298653011441 NMT1/THI5 like; Region: NMT1; pfam09084 298653011442 Transcriptional regulator [Transcription]; Region: IclR; COG1414 298653011443 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 298653011444 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 298653011445 NAD binding site [chemical binding]; other site 298653011446 catalytic residues [active] 298653011447 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 298653011448 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 298653011449 putative NAD(P) binding site [chemical binding]; other site 298653011450 putative substrate binding site [chemical binding]; other site 298653011451 catalytic Zn binding site [ion binding]; other site 298653011452 structural Zn binding site [ion binding]; other site 298653011453 dimer interface [polypeptide binding]; other site 298653011454 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653011455 NAD(P) binding site [chemical binding]; other site 298653011456 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 298653011457 active site 298653011458 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 298653011459 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653011460 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 298653011461 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 298653011462 metabolite-proton symporter; Region: 2A0106; TIGR00883 298653011463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653011464 putative substrate translocation pore; other site 298653011465 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 298653011466 active site 298653011467 catalytic site [active] 298653011468 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 298653011469 putative active site [active] 298653011470 putative catalytic site [active] 298653011471 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653011472 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653011473 active site 298653011474 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 298653011475 active site 298653011476 Transcriptional regulator [Transcription]; Region: IclR; COG1414 298653011477 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 298653011478 Bacterial transcriptional regulator; Region: IclR; pfam01614 298653011479 enoyl-CoA hydratase; Provisional; Region: PRK06688 298653011480 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653011481 substrate binding site [chemical binding]; other site 298653011482 oxyanion hole (OAH) forming residues; other site 298653011483 trimer interface [polypeptide binding]; other site 298653011484 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 298653011485 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 298653011486 active site 298653011487 NAD binding site [chemical binding]; other site 298653011488 metal binding site [ion binding]; metal-binding site 298653011489 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 298653011490 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 298653011491 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 298653011492 short chain dehydrogenase; Provisional; Region: PRK06180 298653011493 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 298653011494 NADP binding site [chemical binding]; other site 298653011495 active site 298653011496 steroid binding site; other site 298653011497 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 298653011498 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 298653011499 active site 298653011500 catalytic tetrad [active] 298653011501 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653011502 salt bridge; other site 298653011503 non-specific DNA binding site [nucleotide binding]; other site 298653011504 sequence-specific DNA binding site [nucleotide binding]; other site 298653011505 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 298653011506 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 298653011507 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 298653011508 active site 298653011509 catalytic tetrad [active] 298653011510 short chain dehydrogenase; Validated; Region: PRK08264 298653011511 NAD(P) binding site [chemical binding]; other site 298653011512 active site 298653011513 Cupin; Region: Cupin_6; pfam12852 298653011514 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 298653011515 Lsr2; Region: Lsr2; pfam11774 298653011516 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653011517 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 298653011518 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653011519 active site 298653011520 substrate binding site [chemical binding]; other site 298653011521 activation loop (A-loop); other site 298653011522 Predicted ATPase [General function prediction only]; Region: COG3899 298653011523 AAA ATPase domain; Region: AAA_16; pfam13191 298653011524 GAF domain; Region: GAF_2; pfam13185 298653011525 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 298653011526 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653011527 metal binding site [ion binding]; metal-binding site 298653011528 active site 298653011529 I-site; other site 298653011530 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653011531 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 298653011532 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 298653011533 hydrophobic ligand binding site; other site 298653011534 Lsr2; Region: Lsr2; pfam11774 298653011535 short chain dehydrogenase; Provisional; Region: PRK07060 298653011536 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653011537 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653011538 active site 298653011539 Transcriptional regulators [Transcription]; Region: FadR; COG2186 298653011540 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 298653011541 DNA-binding site [nucleotide binding]; DNA binding site 298653011542 FCD domain; Region: FCD; pfam07729 298653011543 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653011544 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653011545 NAD(P) binding site [chemical binding]; other site 298653011546 active site 298653011547 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 298653011548 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 298653011549 dimer interface [polypeptide binding]; other site 298653011550 active site 298653011551 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 298653011552 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653011553 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 298653011554 active site 298653011555 catalytic site [active] 298653011556 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 298653011557 active site 2 [active] 298653011558 active site 1 [active] 298653011559 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653011560 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 298653011561 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653011562 active site 298653011563 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653011564 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653011565 active site 298653011566 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 298653011567 classical (c) SDRs; Region: SDR_c; cd05233 298653011568 NAD(P) binding site [chemical binding]; other site 298653011569 active site 298653011570 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653011571 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 298653011572 putative ligand binding site [chemical binding]; other site 298653011573 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 298653011574 TM-ABC transporter signature motif; other site 298653011575 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 298653011576 TM-ABC transporter signature motif; other site 298653011577 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 298653011578 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 298653011579 Walker A/P-loop; other site 298653011580 ATP binding site [chemical binding]; other site 298653011581 Q-loop/lid; other site 298653011582 ABC transporter signature motif; other site 298653011583 Walker B; other site 298653011584 D-loop; other site 298653011585 H-loop/switch region; other site 298653011586 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 298653011587 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 298653011588 Walker A/P-loop; other site 298653011589 ATP binding site [chemical binding]; other site 298653011590 Q-loop/lid; other site 298653011591 ABC transporter signature motif; other site 298653011592 Walker B; other site 298653011593 D-loop; other site 298653011594 H-loop/switch region; other site 298653011595 enoyl-CoA hydratase; Provisional; Region: PRK06688 298653011596 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653011597 substrate binding site [chemical binding]; other site 298653011598 oxyanion hole (OAH) forming residues; other site 298653011599 trimer interface [polypeptide binding]; other site 298653011600 enoyl-CoA hydratase; Provisional; Region: PRK08252 298653011601 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653011602 substrate binding site [chemical binding]; other site 298653011603 oxyanion hole (OAH) forming residues; other site 298653011604 trimer interface [polypeptide binding]; other site 298653011605 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 298653011606 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 298653011607 NAD(P) binding site [chemical binding]; other site 298653011608 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 298653011609 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653011610 substrate binding site [chemical binding]; other site 298653011611 oxyanion hole (OAH) forming residues; other site 298653011612 trimer interface [polypeptide binding]; other site 298653011613 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 298653011614 putative active site [active] 298653011615 putative substrate binding site [chemical binding]; other site 298653011616 ATP binding site [chemical binding]; other site 298653011617 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653011618 classical (c) SDRs; Region: SDR_c; cd05233 298653011619 NAD(P) binding site [chemical binding]; other site 298653011620 active site 298653011621 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653011622 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653011623 enoyl-CoA hydratase; Provisional; Region: PRK08252 298653011624 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653011625 substrate binding site [chemical binding]; other site 298653011626 oxyanion hole (OAH) forming residues; other site 298653011627 trimer interface [polypeptide binding]; other site 298653011628 Transcriptional regulator [Transcription]; Region: IclR; COG1414 298653011629 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 298653011630 Bacterial transcriptional regulator; Region: IclR; pfam01614 298653011631 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653011632 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653011633 active site 298653011634 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 298653011635 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 298653011636 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 298653011637 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 298653011638 dimer interface [polypeptide binding]; other site 298653011639 active site 298653011640 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 298653011641 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 298653011642 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 298653011643 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 298653011644 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653011645 active site 298653011646 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653011647 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 298653011648 active site 298653011649 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653011650 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 298653011651 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 298653011652 active site 298653011653 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653011654 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 298653011655 NAD(P) binding site [chemical binding]; other site 298653011656 active site 298653011657 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653011658 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 298653011659 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653011660 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653011661 Amidohydrolase; Region: Amidohydro_2; pfam04909 298653011662 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 298653011663 classical (c) SDRs; Region: SDR_c; cd05233 298653011664 NAD(P) binding site [chemical binding]; other site 298653011665 active site 298653011666 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 298653011667 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 298653011668 NAD binding site [chemical binding]; other site 298653011669 catalytic residues [active] 298653011670 short chain dehydrogenase; Provisional; Region: PRK06940 298653011671 classical (c) SDRs; Region: SDR_c; cd05233 298653011672 NAD(P) binding site [chemical binding]; other site 298653011673 active site 298653011674 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 298653011675 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653011676 enoyl-CoA hydratase; Provisional; Region: PRK06688 298653011677 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653011678 substrate binding site [chemical binding]; other site 298653011679 oxyanion hole (OAH) forming residues; other site 298653011680 trimer interface [polypeptide binding]; other site 298653011681 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 298653011682 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 298653011683 NAD(P) binding site [chemical binding]; other site 298653011684 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 298653011685 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 298653011686 ligand binding site [chemical binding]; other site 298653011687 active site 298653011688 UGI interface [polypeptide binding]; other site 298653011689 catalytic site [active] 298653011690 Transcriptional regulators [Transcription]; Region: GntR; COG1802 298653011691 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 298653011692 DNA-binding site [nucleotide binding]; DNA binding site 298653011693 FCD domain; Region: FCD; pfam07729 298653011694 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653011695 active site 298653011696 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653011697 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653011698 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653011699 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653011700 DDE superfamily endonuclease; Region: DDE_5; pfam13546 298653011701 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 298653011702 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 298653011703 putative active site [active] 298653011704 putative NTP binding site [chemical binding]; other site 298653011705 putative nucleic acid binding site [nucleotide binding]; other site 298653011706 Type II intron maturase; Region: Intron_maturas2; pfam01348 298653011707 Methyltransferase domain; Region: Methyltransf_23; pfam13489 298653011708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653011709 S-adenosylmethionine binding site [chemical binding]; other site 298653011710 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653011711 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653011712 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653011713 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653011714 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 298653011715 active site 298653011716 Transposase, Mutator family; Region: Transposase_mut; pfam00872 298653011717 MULE transposase domain; Region: MULE; pfam10551 298653011718 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 298653011719 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 298653011720 active site 298653011721 catalytic tetrad [active] 298653011722 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 298653011723 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 298653011724 Walker A/P-loop; other site 298653011725 ATP binding site [chemical binding]; other site 298653011726 Q-loop/lid; other site 298653011727 ABC transporter signature motif; other site 298653011728 Walker B; other site 298653011729 D-loop; other site 298653011730 H-loop/switch region; other site 298653011731 TOBE domain; Region: TOBE_2; pfam08402 298653011732 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 298653011733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653011734 dimer interface [polypeptide binding]; other site 298653011735 conserved gate region; other site 298653011736 putative PBP binding loops; other site 298653011737 ABC-ATPase subunit interface; other site 298653011738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653011739 dimer interface [polypeptide binding]; other site 298653011740 conserved gate region; other site 298653011741 putative PBP binding loops; other site 298653011742 ABC-ATPase subunit interface; other site 298653011743 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 298653011744 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 298653011745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 298653011746 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 298653011747 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653011748 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 298653011749 PAS fold; Region: PAS_4; pfam08448 298653011750 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 298653011751 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653011752 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653011753 Integrase core domain; Region: rve; pfam00665 298653011754 Integrase core domain; Region: rve_3; pfam13683 298653011755 Transposase; Region: DEDD_Tnp_IS110; pfam01548 298653011756 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 298653011757 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 298653011758 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 298653011759 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653011760 PAS domain; Region: PAS_9; pfam13426 298653011761 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 298653011762 putative active site [active] 298653011763 heme pocket [chemical binding]; other site 298653011764 PAS fold; Region: PAS_4; pfam08448 298653011765 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653011766 metal binding site [ion binding]; metal-binding site 298653011767 active site 298653011768 I-site; other site 298653011769 Amidohydrolase; Region: Amidohydro_2; pfam04909 298653011770 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 298653011771 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653011772 lipid-transfer protein; Provisional; Region: PRK07855 298653011773 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 298653011774 active site 298653011775 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 298653011776 DUF35 OB-fold domain; Region: DUF35; pfam01796 298653011777 AMP-binding domain protein; Validated; Region: PRK08315 298653011778 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653011779 Domain of unknown function (DUF4009); Region: DUF4009; pfam13193 298653011780 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653011781 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653011782 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 298653011783 DDE superfamily endonuclease; Region: DDE_5; pfam13546 298653011784 Predicted transcriptional regulators [Transcription]; Region: COG1725 298653011785 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 298653011786 DNA-binding site [nucleotide binding]; DNA binding site 298653011787 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653011788 substrate binding site [chemical binding]; other site 298653011789 activation loop (A-loop); other site 298653011790 AAA ATPase domain; Region: AAA_16; pfam13191 298653011791 Predicted ATPase [General function prediction only]; Region: COG3899 298653011792 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 298653011793 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 298653011794 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653011795 metal binding site [ion binding]; metal-binding site 298653011796 active site 298653011797 I-site; other site 298653011798 Transposase; Region: DDE_Tnp_ISL3; pfam01610 298653011799 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 298653011800 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 298653011801 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 298653011802 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 298653011803 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 298653011804 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 298653011805 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 298653011806 K+ potassium transporter; Region: K_trans; pfam02705 298653011807 Family description; Region: VCBS; pfam13517 298653011808 Transposase; Region: DEDD_Tnp_IS110; pfam01548 298653011809 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 298653011810 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 298653011811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653011812 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 298653011813 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 298653011814 Integrase core domain; Region: rve; pfam00665 298653011815 Integrase core domain; Region: rve_3; pfam13683 298653011816 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 298653011817 PAS fold; Region: PAS; pfam00989 298653011818 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 298653011819 putative active site [active] 298653011820 heme pocket [chemical binding]; other site 298653011821 Histidine kinase; Region: HisKA_3; pfam07730 298653011822 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 298653011823 TrkA-C domain; Region: TrkA_C; pfam02080 298653011824 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 298653011825 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 298653011826 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 298653011827 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 298653011828 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 298653011829 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 298653011830 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 298653011831 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 298653011832 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 298653011833 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 298653011834 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 298653011835 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 298653011836 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 298653011837 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 298653011838 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 298653011839 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 298653011840 xylose isomerase; Provisional; Region: PRK12677 298653011841 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 298653011842 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 298653011843 D-xylulose kinase; Region: XylB; TIGR01312 298653011844 nucleotide binding site [chemical binding]; other site 298653011845 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 298653011846 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 298653011847 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 298653011848 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653011849 Walker A/P-loop; other site 298653011850 ATP binding site [chemical binding]; other site 298653011851 Q-loop/lid; other site 298653011852 ABC transporter signature motif; other site 298653011853 Walker B; other site 298653011854 D-loop; other site 298653011855 H-loop/switch region; other site 298653011856 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 298653011857 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 298653011858 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 298653011859 phosphate binding site [ion binding]; other site 298653011860 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 298653011861 N- and C-terminal domain interface [polypeptide binding]; other site 298653011862 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 298653011863 active site 298653011864 putative catalytic site [active] 298653011865 metal binding site [ion binding]; metal-binding site 298653011866 ATP binding site [chemical binding]; other site 298653011867 carbohydrate binding site [chemical binding]; other site 298653011868 short chain dehydrogenase; Validated; Region: PRK08324 298653011869 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 298653011870 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653011871 NAD(P) binding site [chemical binding]; other site 298653011872 active site 298653011873 Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945 298653011874 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 298653011875 Helix-turn-helix domains; Region: HTH; cl00088 298653011876 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 298653011877 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 298653011878 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 298653011879 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 298653011880 dimer interface [polypeptide binding]; other site 298653011881 NADP binding site [chemical binding]; other site 298653011882 catalytic residues [active] 298653011883 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 298653011884 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 298653011885 NAD(P) binding site [chemical binding]; other site 298653011886 galactonate dehydratase; Provisional; Region: PRK14017 298653011887 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 298653011888 active site pocket [active] 298653011889 Peptidase family U32; Region: Peptidase_U32; cl03113 298653011890 Transcriptional regulators [Transcription]; Region: PurR; COG1609 298653011891 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 298653011892 DNA binding site [nucleotide binding] 298653011893 domain linker motif; other site 298653011894 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 298653011895 ligand binding site [chemical binding]; other site 298653011896 dimerization interface (open form) [polypeptide binding]; other site 298653011897 dimerization interface (closed form) [polypeptide binding]; other site 298653011898 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 298653011899 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 298653011900 inhibitor binding site; inhibition site 298653011901 active site 298653011902 galactokinase; Region: gal_kin; TIGR00131 298653011903 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 298653011904 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 298653011905 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 298653011906 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 298653011907 dimer interface [polypeptide binding]; other site 298653011908 active site 298653011909 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653011910 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 298653011911 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653011912 active site 298653011913 phosphorylation site [posttranslational modification] 298653011914 intermolecular recognition site; other site 298653011915 dimerization interface [polypeptide binding]; other site 298653011916 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653011917 DNA binding residues [nucleotide binding] 298653011918 dimerization interface [polypeptide binding]; other site 298653011919 Histidine kinase; Region: HisKA_3; pfam07730 298653011920 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 298653011921 FHA domain; Region: FHA; pfam00498 298653011922 phosphopeptide binding site; other site 298653011923 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 298653011924 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 298653011925 phosphopeptide binding site; other site 298653011926 ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR). DR is a well-described phenomenon occurring in fungi and shares several similarities with processes...; Region: ABCG_EPDR; cd03213 298653011927 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 298653011928 Walker A/P-loop; other site 298653011929 ATP binding site [chemical binding]; other site 298653011930 Q-loop/lid; other site 298653011931 ABC transporter signature motif; other site 298653011932 Walker B; other site 298653011933 D-loop; other site 298653011934 H-loop/switch region; other site 298653011935 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 298653011936 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 298653011937 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 298653011938 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653011939 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653011940 active site 298653011941 ATP binding site [chemical binding]; other site 298653011942 substrate binding site [chemical binding]; other site 298653011943 activation loop (A-loop); other site 298653011944 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 298653011945 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653011946 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 298653011947 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 298653011948 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 298653011949 spermidine synthase; Provisional; Region: PRK03612 298653011950 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653011951 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653011952 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653011953 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15356 298653011954 AMP-binding enzyme; Region: AMP-binding; cl15778 298653011955 Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080 298653011956 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 298653011957 putative catalytic cysteine [active] 298653011958 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 298653011959 putative dimer interface [polypeptide binding]; other site 298653011960 putative [2Fe-2S] cluster binding site [ion binding]; other site 298653011961 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 298653011962 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 298653011963 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 298653011964 Transcriptional regulators [Transcription]; Region: GntR; COG1802 298653011965 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 298653011966 DNA-binding site [nucleotide binding]; DNA binding site 298653011967 FCD domain; Region: FCD; pfam07729 298653011968 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase_4; pfam13669 298653011969 active site 298653011970 metal binding site [ion binding]; metal-binding site 298653011971 Amidohydrolase; Region: Amidohydro_2; pfam04909 298653011972 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653011973 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653011974 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 298653011975 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 298653011976 substrate binding pocket [chemical binding]; other site 298653011977 active site 298653011978 iron coordination sites [ion binding]; other site 298653011979 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653011980 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653011981 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653011982 NAD(P) binding site [chemical binding]; other site 298653011983 active site 298653011984 Cupin domain; Region: Cupin_2; cl09118 298653011985 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 298653011986 putative hydrophobic ligand binding site [chemical binding]; other site 298653011987 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 298653011988 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 298653011989 catalytic loop [active] 298653011990 iron binding site [ion binding]; other site 298653011991 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 298653011992 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 298653011993 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 298653011994 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 298653011995 classical (c) SDRs; Region: SDR_c; cd05233 298653011996 NAD(P) binding site [chemical binding]; other site 298653011997 active site 298653011998 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 298653011999 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 298653012000 Isochorismatase family; Region: Isochorismatase; pfam00857 298653012001 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 298653012002 catalytic triad [active] 298653012003 conserved cis-peptide bond; other site 298653012004 SnoaL-like domain; Region: SnoaL_4; pfam13577 298653012005 lipid-transfer protein; Provisional; Region: PRK07855 298653012006 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 298653012007 active site 298653012008 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 298653012009 catalytic loop [active] 298653012010 iron binding site [ion binding]; other site 298653012011 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 298653012012 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 298653012013 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 298653012014 [2Fe-2S] cluster binding site [ion binding]; other site 298653012015 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 298653012016 putative alpha subunit interface [polypeptide binding]; other site 298653012017 putative active site [active] 298653012018 putative substrate binding site [chemical binding]; other site 298653012019 Fe binding site [ion binding]; other site 298653012020 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 298653012021 E3 interaction surface; other site 298653012022 lipoyl attachment site [posttranslational modification]; other site 298653012023 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 298653012024 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 298653012025 alpha subunit interface [polypeptide binding]; other site 298653012026 TPP binding site [chemical binding]; other site 298653012027 heterodimer interface [polypeptide binding]; other site 298653012028 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 298653012029 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 298653012030 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 298653012031 tetramer interface [polypeptide binding]; other site 298653012032 TPP-binding site [chemical binding]; other site 298653012033 heterodimer interface [polypeptide binding]; other site 298653012034 phosphorylation loop region [posttranslational modification] 298653012035 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653012036 classical (c) SDRs; Region: SDR_c; cd05233 298653012037 NAD(P) binding site [chemical binding]; other site 298653012038 active site 298653012039 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 298653012040 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 298653012041 active site 298653012042 iron coordination sites [ion binding]; other site 298653012043 substrate binding pocket [chemical binding]; other site 298653012044 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 298653012045 classical (c) SDRs; Region: SDR_c; cd05233 298653012046 NAD(P) binding site [chemical binding]; other site 298653012047 active site 298653012048 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653012049 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653012050 active site 298653012051 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653012052 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 298653012053 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 298653012054 active site 298653012055 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653012056 NAD(P) binding site [chemical binding]; other site 298653012057 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 298653012058 active site 298653012059 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653012060 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653012061 Amidohydrolase; Region: Amidohydro_2; pfam04909 298653012062 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653012063 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 298653012064 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 298653012065 NAD binding site [chemical binding]; other site 298653012066 catalytic residues [active] 298653012067 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653012068 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653012069 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653012070 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 298653012071 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 298653012072 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 298653012073 Walker A/P-loop; other site 298653012074 ATP binding site [chemical binding]; other site 298653012075 Q-loop/lid; other site 298653012076 ABC transporter signature motif; other site 298653012077 Walker B; other site 298653012078 D-loop; other site 298653012079 H-loop/switch region; other site 298653012080 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 298653012081 TM-ABC transporter signature motif; other site 298653012082 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 298653012083 TM-ABC transporter signature motif; other site 298653012084 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 298653012085 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 298653012086 Walker A/P-loop; other site 298653012087 ATP binding site [chemical binding]; other site 298653012088 Q-loop/lid; other site 298653012089 ABC transporter signature motif; other site 298653012090 Walker B; other site 298653012091 D-loop; other site 298653012092 H-loop/switch region; other site 298653012093 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 298653012094 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 298653012095 NAD(P) binding site [chemical binding]; other site 298653012096 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 298653012097 substrate binding site [chemical binding]; other site 298653012098 metal binding site [ion binding]; metal-binding site 298653012099 dimer interface [polypeptide binding]; other site 298653012100 short chain dehydrogenase; Provisional; Region: PRK06940 298653012101 classical (c) SDRs; Region: SDR_c; cd05233 298653012102 NAD(P) binding site [chemical binding]; other site 298653012103 active site 298653012104 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 298653012105 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 298653012106 ATP binding site [chemical binding]; other site 298653012107 Mg++ binding site [ion binding]; other site 298653012108 motif III; other site 298653012109 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 298653012110 nucleotide binding region [chemical binding]; other site 298653012111 ATP-binding site [chemical binding]; other site 298653012112 Amidohydrolase; Region: Amidohydro_2; pfam04909 298653012113 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 298653012114 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 298653012115 active site 298653012116 catalytic residues [active] 298653012117 metal binding site [ion binding]; metal-binding site 298653012118 DmpG-like communication domain; Region: DmpG_comm; pfam07836 298653012119 acetaldehyde dehydrogenase; Validated; Region: PRK08300 298653012120 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 298653012121 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 298653012122 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 298653012123 3-(2,3-dihydroxyphenyl)propionate dioxygenase; Provisional; Region: mhpB; PRK13370 298653012124 active site 298653012125 metal binding site [ion binding]; metal-binding site 298653012126 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 298653012127 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653012128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653012129 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653012130 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653012131 Transcriptional regulator [Transcription]; Region: IclR; COG1414 298653012132 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 298653012133 SnoaL-like domain; Region: SnoaL_4; pfam13577 298653012134 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653012135 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 298653012136 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 298653012137 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 298653012138 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835 298653012139 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 298653012140 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653012141 Domain of unknown function (DUF4009); Region: DUF4009; pfam13193 298653012142 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653012143 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 298653012144 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 298653012145 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 298653012146 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653012147 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 298653012148 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 298653012149 Active site cavity [active] 298653012150 catalytic acid [active] 298653012151 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653012152 metal binding site [ion binding]; metal-binding site 298653012153 active site 298653012154 I-site; other site 298653012155 NB-ARC domain; Region: NB-ARC; pfam00931 298653012156 Tetratricopeptide repeat; Region: TPR_10; pfam13374 298653012157 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653012158 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653012159 multiple promoter invertase; Provisional; Region: mpi; PRK13413 298653012160 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 298653012161 catalytic residues [active] 298653012162 catalytic nucleophile [active] 298653012163 Presynaptic Site I dimer interface [polypeptide binding]; other site 298653012164 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 298653012165 Synaptic Flat tetramer interface [polypeptide binding]; other site 298653012166 Synaptic Site I dimer interface [polypeptide binding]; other site 298653012167 DNA binding site [nucleotide binding] 298653012168 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 298653012169 DNA-binding interface [nucleotide binding]; DNA binding site 298653012170 Cupin; Region: Cupin_6; pfam12852 298653012171 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 298653012172 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 298653012173 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 298653012174 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653012175 NAD(P) binding site [chemical binding]; other site 298653012176 active site 298653012177 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653012178 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 298653012179 Integrase core domain; Region: rve_3; cl15866 298653012180 Predicted transcriptional regulators [Transcription]; Region: COG1733 298653012181 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 298653012182 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 298653012183 putative NAD(P) binding site [chemical binding]; other site 298653012184 Homeodomain-like domain; Region: HTH_23; pfam13384 298653012185 Winged helix-turn helix; Region: HTH_29; pfam13551 298653012186 Homeodomain-like domain; Region: HTH_32; pfam13565 298653012187 Integrase core domain; Region: rve; cl01316 298653012188 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653012189 putative substrate translocation pore; other site 298653012190 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 298653012191 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 298653012192 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 298653012193 FCD domain; Region: FCD; cl11656 298653012194 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 298653012195 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653012196 Uncharacterized conserved protein [Function unknown]; Region: COG2128 298653012197 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 298653012198 Transcriptional regulators [Transcription]; Region: FadR; COG2186 298653012199 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 298653012200 DNA-binding site [nucleotide binding]; DNA binding site 298653012201 FCD domain; Region: FCD; pfam07729 298653012202 enoyl-CoA hydratase; Provisional; Region: PRK06688 298653012203 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653012204 substrate binding site [chemical binding]; other site 298653012205 oxyanion hole (OAH) forming residues; other site 298653012206 trimer interface [polypeptide binding]; other site 298653012207 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 298653012208 active site 1 [active] 298653012209 active site 2 [active] 298653012210 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653012211 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 298653012212 classical (c) SDRs; Region: SDR_c; cd05233 298653012213 NAD(P) binding site [chemical binding]; other site 298653012214 active site 298653012215 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653012216 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 298653012217 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653012218 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653012219 active site 298653012220 ATP binding site [chemical binding]; other site 298653012221 substrate binding site [chemical binding]; other site 298653012222 activation loop (A-loop); other site 298653012223 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 298653012224 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 298653012225 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 298653012226 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 298653012227 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 298653012228 Probable transposase; Region: OrfB_IS605; pfam01385 298653012229 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 298653012230 active site 298653012231 metal binding site [ion binding]; metal-binding site 298653012232 Nuclease-related domain; Region: NERD; pfam08378 298653012233 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 298653012234 ATP binding site [chemical binding]; other site 298653012235 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 298653012236 dimer interface [polypeptide binding]; other site 298653012237 ADP-ribose binding site [chemical binding]; other site 298653012238 active site 298653012239 nudix motif; other site 298653012240 metal binding site [ion binding]; metal-binding site 298653012241 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 298653012242 Coenzyme A binding pocket [chemical binding]; other site 298653012243 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 298653012244 catalytic core [active] 298653012245 PhoD-like phosphatase; Region: PhoD; pfam09423 298653012246 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 298653012247 putative active site [active] 298653012248 putative metal binding site [ion binding]; other site 298653012249 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 298653012250 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653012251 ATP binding site [chemical binding]; other site 298653012252 Mg2+ binding site [ion binding]; other site 298653012253 G-X-G motif; other site 298653012254 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 298653012255 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 298653012256 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 298653012257 active site 298653012258 catalytic tetrad [active] 298653012259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653012260 putative substrate translocation pore; other site 298653012261 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 298653012262 Transposase [DNA replication, recombination, and repair]; Region: COG5421 298653012263 Predicted transcriptional regulators [Transcription]; Region: COG1733 298653012264 dimerization interface [polypeptide binding]; other site 298653012265 putative DNA binding site [nucleotide binding]; other site 298653012266 putative Zn2+ binding site [ion binding]; other site 298653012267 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 298653012268 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 298653012269 active site 298653012270 dimer interface [polypeptide binding]; other site 298653012271 non-prolyl cis peptide bond; other site 298653012272 insertion regions; other site 298653012273 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653012274 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 298653012275 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 298653012276 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 298653012277 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 298653012278 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 298653012279 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 298653012280 Predicted transcriptional regulators [Transcription]; Region: COG1733 298653012281 dimerization interface [polypeptide binding]; other site 298653012282 putative DNA binding site [nucleotide binding]; other site 298653012283 putative Zn2+ binding site [ion binding]; other site 298653012284 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 298653012285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653012286 ABC-ATPase subunit interface; other site 298653012287 putative PBP binding loops; other site 298653012288 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 298653012289 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 298653012290 Walker A/P-loop; other site 298653012291 ATP binding site [chemical binding]; other site 298653012292 Q-loop/lid; other site 298653012293 ABC transporter signature motif; other site 298653012294 Walker B; other site 298653012295 D-loop; other site 298653012296 H-loop/switch region; other site 298653012297 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 298653012298 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 298653012299 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 298653012300 Walker A/P-loop; other site 298653012301 ATP binding site [chemical binding]; other site 298653012302 Q-loop/lid; other site 298653012303 ABC transporter signature motif; other site 298653012304 Walker B; other site 298653012305 D-loop; other site 298653012306 H-loop/switch region; other site 298653012307 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 298653012308 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 298653012309 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 298653012310 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 298653012311 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 298653012312 nudix motif; other site 298653012313 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 298653012314 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 298653012315 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 298653012316 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 298653012317 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 298653012318 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653012319 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 298653012320 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 298653012321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653012322 dimer interface [polypeptide binding]; other site 298653012323 conserved gate region; other site 298653012324 ABC-ATPase subunit interface; other site 298653012325 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 298653012326 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 298653012327 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 298653012328 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653012329 S-adenosylmethionine binding site [chemical binding]; other site 298653012330 AAA ATPase domain; Region: AAA_16; pfam13191 298653012331 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653012332 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653012333 DNA binding residues [nucleotide binding] 298653012334 dimerization interface [polypeptide binding]; other site 298653012335 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 298653012336 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653012337 N-acetyltransferase; Region: Acetyltransf_2; cl00949 298653012338 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 298653012339 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 298653012340 active site 298653012341 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 298653012342 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 298653012343 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 298653012344 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 298653012345 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 298653012346 active site 298653012347 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 298653012348 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 298653012349 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 298653012350 putative NADP binding site [chemical binding]; other site 298653012351 active site 298653012352 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 298653012353 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 298653012354 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653012355 Domain of unknown function (DUF4009); Region: DUF4009; pfam13193 298653012356 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 298653012357 putative NADP binding site [chemical binding]; other site 298653012358 active site 298653012359 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 298653012360 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 298653012361 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 298653012362 active site 298653012363 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 298653012364 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 298653012365 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 298653012366 putative NADP binding site [chemical binding]; other site 298653012367 active site 298653012368 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 298653012369 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 298653012370 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 298653012371 active site 298653012372 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 298653012373 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 298653012374 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 298653012375 putative NADP binding site [chemical binding]; other site 298653012376 active site 298653012377 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 298653012378 3-amino-5-hydroxybenoic acid synthesis related protein; Region: AHBA_synth_RP; TIGR01454 298653012379 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 298653012380 motif II; other site 298653012381 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 298653012382 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 298653012383 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 298653012384 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 298653012385 inhibitor-cofactor binding pocket; inhibition site 298653012386 pyridoxal 5'-phosphate binding site [chemical binding]; other site 298653012387 catalytic residue [active] 298653012388 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 298653012389 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 298653012390 cyclase homology domain; Region: CHD; cd07302 298653012391 dimer interface [polypeptide binding]; other site 298653012392 nucleotidyl binding site; other site 298653012393 metal binding site [ion binding]; metal-binding site 298653012394 AAA ATPase domain; Region: AAA_16; pfam13191 298653012395 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 298653012396 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 298653012397 Predicted transcriptional regulators [Transcription]; Region: COG1733 298653012398 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653012399 NAD(P) binding site [chemical binding]; other site 298653012400 active site 298653012401 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 298653012402 nudix motif; other site 298653012403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653012404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653012405 hypothetical protein; Validated; Region: PRK06840 298653012406 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827 298653012407 dimer interface [polypeptide binding]; other site 298653012408 active site 298653012409 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 298653012410 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 298653012411 Acylphosphatase; Region: Acylphosphatase; pfam00708 298653012412 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 298653012413 HypF finger; Region: zf-HYPF; pfam07503 298653012414 HypF finger; Region: zf-HYPF; pfam07503 298653012415 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 298653012416 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 298653012417 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 298653012418 active site 298653012419 SnoaL-like domain; Region: SnoaL_4; pfam13577 298653012420 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 298653012421 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 298653012422 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 298653012423 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 298653012424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653012425 Methyltransferase domain; Region: Methyltransf_31; pfam13847 298653012426 S-adenosylmethionine binding site [chemical binding]; other site 298653012427 putative acetyltransferase; Provisional; Region: PRK03624 298653012428 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 298653012429 Coenzyme A binding pocket [chemical binding]; other site 298653012430 Domain of unknown function (DUF222); Region: DUF222; pfam02720 298653012431 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 298653012432 active site 298653012433 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 298653012434 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 298653012435 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 298653012436 cobyric acid synthase; Provisional; Region: PRK00784 298653012437 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653012438 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653012439 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 298653012440 catalytic triad [active] 298653012441 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 298653012442 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 298653012443 Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723 298653012444 DEAD-like helicases superfamily; Region: DEXDc; smart00487 298653012445 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 298653012446 ATP binding site [chemical binding]; other site 298653012447 putative Mg++ binding site [ion binding]; other site 298653012448 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 298653012449 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 298653012450 nucleotide binding region [chemical binding]; other site 298653012451 ATP-binding site [chemical binding]; other site 298653012452 rRNA-processing arch domain; Region: rRNA_proc-arch; pfam13234 298653012453 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 298653012454 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 298653012455 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 298653012456 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 298653012457 Predicted transcriptional regulator [Transcription]; Region: COG2378 298653012458 WYL domain; Region: WYL; pfam13280 298653012459 WYL domain; Region: WYL; pfam13280 298653012460 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 298653012461 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 298653012462 Dienelactone hydrolase family; Region: DLH; pfam01738 298653012463 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653012464 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653012465 S-adenosylmethionine binding site [chemical binding]; other site 298653012466 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 298653012467 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 298653012468 active site 298653012469 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]; Region: PRE1; COG0638 298653012470 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 298653012471 active site 298653012472 Pup-like protein; Region: Pup; pfam05639 298653012473 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 298653012474 proteasome ATPase; Region: pup_AAA; TIGR03689 298653012475 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 298653012476 Walker A motif; other site 298653012477 ATP binding site [chemical binding]; other site 298653012478 Walker B motif; other site 298653012479 arginine finger; other site 298653012480 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 298653012481 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 298653012482 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 298653012483 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 298653012484 active site 298653012485 putative substrate binding region [chemical binding]; other site 298653012486 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 298653012487 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 298653012488 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 298653012489 Walker A/P-loop; other site 298653012490 ATP binding site [chemical binding]; other site 298653012491 Q-loop/lid; other site 298653012492 ABC transporter signature motif; other site 298653012493 Walker B; other site 298653012494 D-loop; other site 298653012495 H-loop/switch region; other site 298653012496 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 298653012497 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 298653012498 FtsX-like permease family; Region: FtsX; pfam02687 298653012499 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 298653012500 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 298653012501 FtsX-like permease family; Region: FtsX; pfam02687 298653012502 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 298653012503 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 298653012504 PAC2 family; Region: PAC2; pfam09754 298653012505 DivIVA protein; Region: DivIVA; pfam05103 298653012506 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 298653012507 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 298653012508 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 298653012509 active site 298653012510 HIGH motif; other site 298653012511 nucleotide binding site [chemical binding]; other site 298653012512 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 298653012513 active site 298653012514 KMSKS motif; other site 298653012515 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 298653012516 tRNA binding surface [nucleotide binding]; other site 298653012517 anticodon binding site; other site 298653012518 conserved hypothetical protein; Region: TIGR03843 298653012519 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 298653012520 catalytic core [active] 298653012521 AAA domain; Region: AAA_30; pfam13604 298653012522 Family description; Region: UvrD_C_2; pfam13538 298653012523 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 298653012524 hypothetical protein; Provisional; Region: PRK07208 298653012525 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 298653012526 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 298653012527 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 298653012528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653012529 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 298653012530 hypothetical protein; Provisional; Region: PRK07906 298653012531 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 298653012532 putative metal binding site [ion binding]; other site 298653012533 TM2 domain; Region: TM2; pfam05154 298653012534 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 298653012535 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 298653012536 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653012537 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 298653012538 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653012539 Walker A/P-loop; other site 298653012540 ATP binding site [chemical binding]; other site 298653012541 Q-loop/lid; other site 298653012542 ABC transporter signature motif; other site 298653012543 Walker B; other site 298653012544 D-loop; other site 298653012545 H-loop/switch region; other site 298653012546 ABC transporter; Region: ABC_tran_2; pfam12848 298653012547 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 298653012548 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653012549 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653012550 active site 298653012551 ATP binding site [chemical binding]; other site 298653012552 substrate binding site [chemical binding]; other site 298653012553 activation loop (A-loop); other site 298653012554 Domain of unknown function (DUF309); Region: DUF309; pfam03745 298653012555 Predicted membrane protein [Function unknown]; Region: COG2261 298653012556 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 298653012557 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 298653012558 active site 298653012559 catalytic site [active] 298653012560 substrate binding site [chemical binding]; other site 298653012561 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 298653012562 non-specific DNA binding site [nucleotide binding]; other site 298653012563 salt bridge; other site 298653012564 sequence-specific DNA binding site [nucleotide binding]; other site 298653012565 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653012566 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653012567 active site 298653012568 ATP binding site [chemical binding]; other site 298653012569 substrate binding site [chemical binding]; other site 298653012570 activation loop (A-loop); other site 298653012571 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 298653012572 nudix motif; other site 298653012573 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 298653012574 DNA binding residues [nucleotide binding] 298653012575 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 298653012576 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 298653012577 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 298653012578 DNA binding residues [nucleotide binding] 298653012579 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 298653012580 Clp protease; Region: CLP_protease; pfam00574 298653012581 oligomer interface [polypeptide binding]; other site 298653012582 active site residues [active] 298653012583 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 298653012584 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 298653012585 oligomer interface [polypeptide binding]; other site 298653012586 active site residues [active] 298653012587 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653012588 non-specific DNA binding site [nucleotide binding]; other site 298653012589 sequence-specific DNA binding site [nucleotide binding]; other site 298653012590 salt bridge; other site 298653012591 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 298653012592 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 298653012593 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 298653012594 catalytic residue [active] 298653012595 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 298653012596 AAA domain; Region: AAA_30; pfam13604 298653012597 Family description; Region: UvrD_C_2; pfam13538 298653012598 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653012599 WHG domain; Region: WHG; pfam13305 298653012600 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 298653012601 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 298653012602 putative acyl-acceptor binding pocket; other site 298653012603 Sulfatase; Region: Sulfatase; cl10460 298653012604 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 298653012605 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 298653012606 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 298653012607 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 298653012608 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653012609 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653012610 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653012611 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653012612 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 298653012613 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653012614 AMP-binding enzyme; Region: AMP-binding; cl15778 298653012615 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 298653012616 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 298653012617 Sulfotransferase family; Region: Sulfotransfer_3; cl14559 298653012618 RNA polymerase factor sigma-70; Validated; Region: PRK08241 298653012619 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 298653012620 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 298653012621 DNA binding residues [nucleotide binding] 298653012622 SnoaL-like domain; Region: SnoaL_2; pfam12680 298653012623 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 298653012624 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 298653012625 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 298653012626 substrate binding pocket [chemical binding]; other site 298653012627 membrane-bound complex binding site; other site 298653012628 hinge residues; other site 298653012629 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653012630 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653012631 active site 298653012632 ATP binding site [chemical binding]; other site 298653012633 substrate binding site [chemical binding]; other site 298653012634 activation loop (A-loop); other site 298653012635 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 298653012636 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 298653012637 metal ion-dependent adhesion site (MIDAS); other site 298653012638 FHA domain; Region: FHA; pfam00498 298653012639 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 298653012640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653012641 S-adenosylmethionine binding site [chemical binding]; other site 298653012642 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 298653012643 Thioredoxin; Region: Thioredoxin_4; pfam13462 298653012644 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 298653012645 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 298653012646 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 298653012647 Walker A/P-loop; other site 298653012648 ATP binding site [chemical binding]; other site 298653012649 Q-loop/lid; other site 298653012650 ABC transporter signature motif; other site 298653012651 Walker B; other site 298653012652 D-loop; other site 298653012653 H-loop/switch region; other site 298653012654 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 298653012655 ABC-2 type transporter; Region: ABC2_membrane; cl11417 298653012656 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 298653012657 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 298653012658 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653012659 Walker A/P-loop; other site 298653012660 ATP binding site [chemical binding]; other site 298653012661 Q-loop/lid; other site 298653012662 ABC transporter signature motif; other site 298653012663 Walker B; other site 298653012664 D-loop; other site 298653012665 H-loop/switch region; other site 298653012666 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 298653012667 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 298653012668 active site 298653012669 catalytic site [active] 298653012670 Helix-turn-helix domains; Region: HTH; cl00088 298653012671 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 298653012672 SnoaL-like domain; Region: SnoaL_4; pfam13577 298653012673 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 298653012674 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 298653012675 active site 298653012676 catalytic tetrad [active] 298653012677 enoyl-CoA hydratase; Provisional; Region: PRK09245 298653012678 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653012679 substrate binding site [chemical binding]; other site 298653012680 oxyanion hole (OAH) forming residues; other site 298653012681 trimer interface [polypeptide binding]; other site 298653012682 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 298653012683 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 298653012684 Zn binding site [ion binding]; other site 298653012685 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 298653012686 substrate binding site [chemical binding]; other site 298653012687 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 298653012688 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 298653012689 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 298653012690 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 298653012691 active site 298653012692 putative homodimer interface [polypeptide binding]; other site 298653012693 SAM binding site [chemical binding]; other site 298653012694 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 298653012695 uridine kinase; Validated; Region: PRK06696 298653012696 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653012697 active site 298653012698 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 298653012699 Coenzyme A binding pocket [chemical binding]; other site 298653012700 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 298653012701 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 298653012702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653012703 Rhomboid family; Region: Rhomboid; pfam01694 298653012704 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653012705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653012706 active site 298653012707 phosphorylation site [posttranslational modification] 298653012708 intermolecular recognition site; other site 298653012709 dimerization interface [polypeptide binding]; other site 298653012710 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653012711 DNA binding residues [nucleotide binding] 298653012712 dimerization interface [polypeptide binding]; other site 298653012713 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 298653012714 Histidine kinase; Region: HisKA_3; pfam07730 298653012715 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653012716 ATP binding site [chemical binding]; other site 298653012717 Mg2+ binding site [ion binding]; other site 298653012718 G-X-G motif; other site 298653012719 Cysteine dioxygenase type I; Region: CDO_I; cl15835 298653012720 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 298653012721 active site residue [active] 298653012722 Transcription factor WhiB; Region: Whib; pfam02467 298653012723 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 298653012724 catalytic core [active] 298653012725 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 298653012726 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 298653012727 active site 298653012728 homotetramer interface [polypeptide binding]; other site 298653012729 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653012730 ABC-2 type transporter; Region: ABC2_membrane; cl11417 298653012731 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 298653012732 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653012733 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 298653012734 Walker A/P-loop; other site 298653012735 ATP binding site [chemical binding]; other site 298653012736 Q-loop/lid; other site 298653012737 ABC transporter signature motif; other site 298653012738 Walker B; other site 298653012739 D-loop; other site 298653012740 H-loop/switch region; other site 298653012741 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 298653012742 DNA binding residues [nucleotide binding] 298653012743 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 298653012744 Bifunctional nuclease; Region: DNase-RNase; pfam02577 298653012745 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 298653012746 DNA binding residues [nucleotide binding] 298653012747 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 298653012748 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 298653012749 Double zinc ribbon; Region: DZR; pfam12773 298653012750 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 298653012751 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 298653012752 phosphopeptide binding site; other site 298653012753 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 298653012754 lipoyl attachment site [posttranslational modification]; other site 298653012755 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 298653012756 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 298653012757 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 298653012758 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 298653012759 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 298653012760 active site 298653012761 Substrate binding site; other site 298653012762 Mg++ binding site; other site 298653012763 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 298653012764 putative trimer interface [polypeptide binding]; other site 298653012765 putative CoA binding site [chemical binding]; other site 298653012766 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 298653012767 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 298653012768 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 298653012769 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 298653012770 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 298653012771 NlpC/P60 family; Region: NLPC_P60; pfam00877 298653012772 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 298653012773 active site 298653012774 putative catalytic site [active] 298653012775 Helix-turn-helix domain; Region: HTH_17; pfam12728 298653012776 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653012777 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 298653012778 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 298653012779 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 298653012780 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 298653012781 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 298653012782 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 298653012783 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 298653012784 NADP+ binding site [chemical binding]; other site 298653012785 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 298653012786 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653012787 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653012788 DNA binding residues [nucleotide binding] 298653012789 dimerization interface [polypeptide binding]; other site 298653012790 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 298653012791 SnoaL-like domain; Region: SnoaL_2; pfam12680 298653012792 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 298653012793 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 298653012794 Helix-turn-helix domains; Region: HTH; cl00088 298653012795 putative DNA binding site [nucleotide binding]; other site 298653012796 putative Zn2+ binding site [ion binding]; other site 298653012797 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 298653012798 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 298653012799 putative NAD(P) binding site [chemical binding]; other site 298653012800 Cation efflux family; Region: Cation_efflux; pfam01545 298653012801 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 298653012802 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 298653012803 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 298653012804 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 298653012805 putative DNA binding site [nucleotide binding]; other site 298653012806 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 298653012807 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 298653012808 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 298653012809 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 298653012810 dimer interface [polypeptide binding]; other site 298653012811 ssDNA binding site [nucleotide binding]; other site 298653012812 tetramer (dimer of dimers) interface [polypeptide binding]; other site 298653012813 Helix-turn-helix domains; Region: HTH; cl00088 298653012814 DNA binding residues [nucleotide binding] 298653012815 GTP-binding protein Der; Reviewed; Region: PRK03003 298653012816 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 298653012817 G1 box; other site 298653012818 GTP/Mg2+ binding site [chemical binding]; other site 298653012819 Switch I region; other site 298653012820 G2 box; other site 298653012821 Switch II region; other site 298653012822 G3 box; other site 298653012823 G4 box; other site 298653012824 G5 box; other site 298653012825 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 298653012826 G1 box; other site 298653012827 GTP/Mg2+ binding site [chemical binding]; other site 298653012828 Switch I region; other site 298653012829 G2 box; other site 298653012830 G3 box; other site 298653012831 Switch II region; other site 298653012832 G4 box; other site 298653012833 G5 box; other site 298653012834 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 298653012835 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 298653012836 putative acyl-acceptor binding pocket; other site 298653012837 cytidylate kinase; Provisional; Region: cmk; PRK00023 298653012838 AAA domain; Region: AAA_17; pfam13207 298653012839 active site 298653012840 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 298653012841 CMP-binding site; other site 298653012842 The sites determining sugar specificity; other site 298653012843 prephenate dehydrogenase; Validated; Region: PRK06545 298653012844 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653012845 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 298653012846 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 298653012847 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 298653012848 active site 298653012849 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 298653012850 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 298653012851 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 298653012852 active site 298653012853 putative substrate binding region [chemical binding]; other site 298653012854 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 298653012855 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 298653012856 P-loop; other site 298653012857 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653012858 Magnesium ion binding site [ion binding]; other site 298653012859 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 298653012860 Magnesium ion binding site [ion binding]; other site 298653012861 mycothiol-dependent formaldehyde dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 298653012862 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 298653012863 NAD binding site [chemical binding]; other site 298653012864 catalytic Zn binding site [ion binding]; other site 298653012865 substrate binding site [chemical binding]; other site 298653012866 structural Zn binding site [ion binding]; other site 298653012867 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 298653012868 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 298653012869 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 298653012870 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 298653012871 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 298653012872 DNA binding residues [nucleotide binding] 298653012873 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 298653012874 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 298653012875 RNA/DNA hybrid binding site [nucleotide binding]; other site 298653012876 active site 298653012877 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 298653012878 catalytic core [active] 298653012879 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 298653012880 Putative zinc ribbon domain; Region: DUF164; pfam02591 298653012881 Uncharacterized conserved protein [Function unknown]; Region: COG0327 298653012882 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 298653012883 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 298653012884 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 298653012885 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 298653012886 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653012887 Walker A/P-loop; other site 298653012888 ATP binding site [chemical binding]; other site 298653012889 Q-loop/lid; other site 298653012890 ABC transporter signature motif; other site 298653012891 Walker B; other site 298653012892 D-loop; other site 298653012893 H-loop/switch region; other site 298653012894 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 298653012895 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 298653012896 active site 298653012897 lipoprotein signal peptidase; Provisional; Region: PRK14764 298653012898 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 298653012899 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 298653012900 HIGH motif; other site 298653012901 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 298653012902 active site 298653012903 KMSKS motif; other site 298653012904 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 298653012905 tRNA binding surface [nucleotide binding]; other site 298653012906 anticodon binding site; other site 298653012907 DivIVA protein; Region: DivIVA; pfam05103 298653012908 DivIVA domain; Region: DivI1A_domain; TIGR03544 298653012909 Protein of unknown function (DUF552); Region: DUF552; pfam04472 298653012910 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 298653012911 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 298653012912 catalytic residue [active] 298653012913 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 298653012914 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 298653012915 cell division protein FtsZ; Validated; Region: PRK09330 298653012916 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 298653012917 nucleotide binding site [chemical binding]; other site 298653012918 SulA interaction site; other site 298653012919 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 298653012920 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 298653012921 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 298653012922 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 298653012923 Domain of unknown function (DUF385); Region: DUF385; cl04387 298653012924 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 298653012925 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 298653012926 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 298653012927 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 298653012928 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 298653012929 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 298653012930 active site 298653012931 homodimer interface [polypeptide binding]; other site 298653012932 cell division protein FtsW; Region: ftsW; TIGR02614 298653012933 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 298653012934 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 298653012935 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 298653012936 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 298653012937 Mg++ binding site [ion binding]; other site 298653012938 putative catalytic motif [active] 298653012939 putative substrate binding site [chemical binding]; other site 298653012940 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 298653012941 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 298653012942 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 298653012943 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 298653012944 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 298653012945 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 298653012946 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 298653012947 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 298653012948 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 298653012949 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 298653012950 Sec24-related protein; Provisional; Region: PTZ00395 298653012951 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 298653012952 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 298653012953 cell division protein MraZ; Reviewed; Region: PRK00326 298653012954 MraZ protein; Region: MraZ; pfam02381 298653012955 MraZ protein; Region: MraZ; pfam02381 298653012956 MoxR-like ATPases [General function prediction only]; Region: COG0714 298653012957 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 298653012958 Walker A motif; other site 298653012959 ATP binding site [chemical binding]; other site 298653012960 Walker B motif; other site 298653012961 arginine finger; other site 298653012962 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 298653012963 Protein of unknown function DUF58; Region: DUF58; pfam01882 298653012964 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 298653012965 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 298653012966 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 298653012967 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 298653012968 active site 298653012969 DNA polymerase IV; Validated; Region: PRK02406 298653012970 DNA binding site [nucleotide binding] 298653012971 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 298653012972 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 298653012973 Probable transposase; Region: OrfB_IS605; pfam01385 298653012974 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 298653012975 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 298653012976 DNA binding site [nucleotide binding] 298653012977 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 298653012978 NB-ARC domain; Region: NB-ARC; pfam00931 298653012979 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653012980 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 298653012981 Coenzyme A binding pocket [chemical binding]; other site 298653012982 Protein of unknown function (DUF422); Region: DUF422; cl00991 298653012983 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 298653012984 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 298653012985 active site 298653012986 phytoene desaturase; Region: crtI_fam; TIGR02734 298653012987 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 298653012988 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 298653012989 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 298653012990 FAD binding site [chemical binding]; other site 298653012991 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 298653012992 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 298653012993 phytoene desaturase; Region: crtI_fam; TIGR02734 298653012994 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 298653012995 MoxR-like ATPases [General function prediction only]; Region: COG0714 298653012996 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 298653012997 Walker A motif; other site 298653012998 ATP binding site [chemical binding]; other site 298653012999 Walker B motif; other site 298653013000 arginine finger; other site 298653013001 Protein of unknown function DUF58; Region: DUF58; pfam01882 298653013002 von Willebrand factor type A domain; Region: VWA_2; pfam13519 298653013003 metal ion-dependent adhesion site (MIDAS); other site 298653013004 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 298653013005 active site lid residues [active] 298653013006 substrate binding pocket [chemical binding]; other site 298653013007 catalytic residues [active] 298653013008 substrate-Mg2+ binding site; other site 298653013009 aspartate-rich region 1; other site 298653013010 aspartate-rich region 2; other site 298653013011 seryl-tRNA synthetase; Provisional; Region: PRK05431 298653013012 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 298653013013 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 298653013014 dimer interface [polypeptide binding]; other site 298653013015 active site 298653013016 motif 1; other site 298653013017 motif 2; other site 298653013018 motif 3; other site 298653013019 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 298653013020 active site 298653013021 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 298653013022 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 298653013023 ATP binding site [chemical binding]; other site 298653013024 putative Mg++ binding site [ion binding]; other site 298653013025 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653013026 non-specific DNA binding site [nucleotide binding]; other site 298653013027 salt bridge; other site 298653013028 sequence-specific DNA binding site [nucleotide binding]; other site 298653013029 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 298653013030 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 298653013031 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 298653013032 Zn2+ binding site [ion binding]; other site 298653013033 Mg2+ binding site [ion binding]; other site 298653013034 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 298653013035 synthetase active site [active] 298653013036 NTP binding site [chemical binding]; other site 298653013037 metal binding site [ion binding]; metal-binding site 298653013038 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 298653013039 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 298653013040 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 298653013041 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 298653013042 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 298653013043 Zn2+ binding site [ion binding]; other site 298653013044 Mg2+ binding site [ion binding]; other site 298653013045 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 298653013046 synthetase active site [active] 298653013047 NTP binding site [chemical binding]; other site 298653013048 metal binding site [ion binding]; metal-binding site 298653013049 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 298653013050 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 298653013051 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 298653013052 active site 298653013053 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 298653013054 Protein export membrane protein; Region: SecD_SecF; pfam02355 298653013055 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 298653013056 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 298653013057 Preprotein translocase subunit; Region: YajC; pfam02699 298653013058 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 298653013059 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 298653013060 Walker A motif; other site 298653013061 ATP binding site [chemical binding]; other site 298653013062 Walker B motif; other site 298653013063 arginine finger; other site 298653013064 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 298653013065 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 298653013066 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 298653013067 active site 298653013068 putative DNA-binding cleft [nucleotide binding]; other site 298653013069 dimer interface [polypeptide binding]; other site 298653013070 hypothetical protein; Validated; Region: PRK00110 298653013071 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 298653013072 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 298653013073 predicted active site [active] 298653013074 catalytic triad [active] 298653013075 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 298653013076 active site 298653013077 multimer interface [polypeptide binding]; other site 298653013078 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 298653013079 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 298653013080 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 298653013081 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 298653013082 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 298653013083 putative acyl-acceptor binding pocket; other site 298653013084 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 298653013085 elongation factor G; Reviewed; Region: PRK12740 298653013086 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653013087 G2 box; other site 298653013088 Switch I region; other site 298653013089 G3 box; other site 298653013090 Switch II region; other site 298653013091 GTP/Mg2+ binding site [chemical binding]; other site 298653013092 G4 box; other site 298653013093 G5 box; other site 298653013094 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 298653013095 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 298653013096 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 298653013097 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 298653013098 nucleotide binding site/active site [active] 298653013099 HIT family signature motif; other site 298653013100 catalytic residue [active] 298653013101 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653013102 Cytochrome P450; Region: p450; pfam00067 298653013103 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 298653013104 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 298653013105 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 298653013106 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 298653013107 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 298653013108 active site 298653013109 metal binding site [ion binding]; metal-binding site 298653013110 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 298653013111 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 298653013112 Isochorismatase family; Region: Isochorismatase; pfam00857 298653013113 catalytic triad [active] 298653013114 conserved cis-peptide bond; other site 298653013115 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 298653013116 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 298653013117 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 298653013118 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 298653013119 active site 298653013120 catalytic site [active] 298653013121 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 298653013122 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 298653013123 active site 298653013124 catalytic site [active] 298653013125 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 298653013126 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 298653013127 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 298653013128 catalytic site [active] 298653013129 active site 298653013130 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 298653013131 hypothetical protein; Provisional; Region: PRK14059 298653013132 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 298653013133 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 298653013134 active site 298653013135 DNA binding site [nucleotide binding] 298653013136 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 298653013137 DNA binding site [nucleotide binding] 298653013138 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 298653013139 active site 298653013140 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 298653013141 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 298653013142 ligand-binding site [chemical binding]; other site 298653013143 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 298653013144 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653013145 Bacterial sugar transferase; Region: Bac_transf; pfam02397 298653013146 Chlorite dismutase; Region: Chlor_dismutase; pfam06778 298653013147 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 298653013148 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 298653013149 substrate binding site [chemical binding]; other site 298653013150 active site 298653013151 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 298653013152 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 298653013153 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 298653013154 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 298653013155 catalytic site [active] 298653013156 putative active site [active] 298653013157 putative substrate binding site [chemical binding]; other site 298653013158 Helicase and RNase D C-terminal; Region: HRDC; smart00341 298653013159 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 298653013160 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 298653013161 dimer interface [polypeptide binding]; other site 298653013162 active site 298653013163 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653013164 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 298653013165 substrate binding site [chemical binding]; other site 298653013166 oxyanion hole (OAH) forming residues; other site 298653013167 trimer interface [polypeptide binding]; other site 298653013168 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 298653013169 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653013170 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653013171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653013172 Major Facilitator Superfamily; Region: MFS_1; pfam07690 298653013173 putative substrate translocation pore; other site 298653013174 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653013175 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 298653013176 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 298653013177 TPP-binding site; other site 298653013178 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 298653013179 PYR/PP interface [polypeptide binding]; other site 298653013180 dimer interface [polypeptide binding]; other site 298653013181 TPP binding site [chemical binding]; other site 298653013182 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 298653013183 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism]; Region: AraH; COG1172 298653013184 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 298653013185 TM-ABC transporter signature motif; other site 298653013186 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 298653013187 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653013188 Walker A/P-loop; other site 298653013189 ATP binding site [chemical binding]; other site 298653013190 Q-loop/lid; other site 298653013191 ABC transporter signature motif; other site 298653013192 Walker B; other site 298653013193 D-loop; other site 298653013194 H-loop/switch region; other site 298653013195 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 298653013196 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 298653013197 putative ligand binding site [chemical binding]; other site 298653013198 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 298653013199 non-specific DNA interactions [nucleotide binding]; other site 298653013200 DNA binding site [nucleotide binding] 298653013201 sequence specific DNA binding site [nucleotide binding]; other site 298653013202 putative cAMP binding site [chemical binding]; other site 298653013203 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 298653013204 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 298653013205 nucleotide binding site [chemical binding]; other site 298653013206 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 298653013207 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 298653013208 Amino acid permease; Region: AA_permease_2; pfam13520 298653013209 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 298653013210 TrkA-N domain; Region: TrkA_N; pfam02254 298653013211 TrkA-C domain; Region: TrkA_C; pfam02080 298653013212 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 298653013213 TrkA-N domain; Region: TrkA_N; pfam02254 298653013214 TrkA-C domain; Region: TrkA_C; pfam02080 298653013215 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 298653013216 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 298653013217 generic binding surface II; other site 298653013218 ssDNA binding site; other site 298653013219 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 298653013220 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 298653013221 trimer interface [polypeptide binding]; other site 298653013222 active site 298653013223 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 298653013224 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 298653013225 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 298653013226 trimer interface [polypeptide binding]; other site 298653013227 putative metal binding site [ion binding]; other site 298653013228 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 298653013229 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 298653013230 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 298653013231 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 298653013232 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 298653013233 active site 298653013234 HIGH motif; other site 298653013235 nucleotide binding site [chemical binding]; other site 298653013236 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 298653013237 active site 298653013238 KMSKS motif; other site 298653013239 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 298653013240 tRNA binding surface [nucleotide binding]; other site 298653013241 anticodon binding site; other site 298653013242 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 298653013243 active site 298653013244 dimerization interface [polypeptide binding]; other site 298653013245 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 298653013246 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 298653013247 active site 298653013248 homodimer interface [polypeptide binding]; other site 298653013249 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 298653013250 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 298653013251 NADP binding site [chemical binding]; other site 298653013252 active site 298653013253 putative substrate binding site [chemical binding]; other site 298653013254 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653013255 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 298653013256 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 298653013257 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 298653013258 NodB motif; other site 298653013259 active site 298653013260 catalytic site [active] 298653013261 metal binding site [ion binding]; metal-binding site 298653013262 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 298653013263 PAC2 family; Region: PAC2; pfam09754 298653013264 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 298653013265 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 298653013266 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 298653013267 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 298653013268 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 298653013269 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 298653013270 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 298653013271 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 298653013272 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 298653013273 ADP-ribose binding site [chemical binding]; other site 298653013274 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 298653013275 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 298653013276 dimer interface [polypeptide binding]; other site 298653013277 ADP-ribose binding site [chemical binding]; other site 298653013278 active site 298653013279 nudix motif; other site 298653013280 metal binding site [ion binding]; metal-binding site 298653013281 Uncharacterized protein family (UPF0146); Region: UPF0146; cl00552 298653013282 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 298653013283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 298653013284 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653013285 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653013286 active site 298653013287 ATP binding site [chemical binding]; other site 298653013288 substrate binding site [chemical binding]; other site 298653013289 activation loop (A-loop); other site 298653013290 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 298653013291 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 298653013292 active site 298653013293 nucleotide binding site [chemical binding]; other site 298653013294 HIGH motif; other site 298653013295 KMSKS motif; other site 298653013296 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 298653013297 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 298653013298 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653013299 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653013300 Protein of unknown function (DUF664); Region: DUF664; pfam04978 298653013301 DinB superfamily; Region: DinB_2; pfam12867 298653013302 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 298653013303 Sulfate transporter family; Region: Sulfate_transp; pfam00916 298653013304 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 298653013305 active site clefts [active] 298653013306 zinc binding site [ion binding]; other site 298653013307 dimer interface [polypeptide binding]; other site 298653013308 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 298653013309 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 298653013310 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653013311 classical (c) SDRs; Region: SDR_c; cd05233 298653013312 NAD(P) binding site [chemical binding]; other site 298653013313 active site 298653013314 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 298653013315 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653013316 NAD(P) binding site [chemical binding]; other site 298653013317 active site 298653013318 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653013319 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653013320 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653013321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653013322 S-adenosylmethionine binding site [chemical binding]; other site 298653013323 MMPL family; Region: MMPL; pfam03176 298653013324 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 298653013325 activation loop (A-loop); other site 298653013326 Tubulin like; Region: Tubulin_2; pfam13809 298653013327 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 298653013328 metal ion-dependent adhesion site (MIDAS); other site 298653013329 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 298653013330 active site 298653013331 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 298653013332 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653013333 Walker B; other site 298653013334 D-loop; other site 298653013335 H-loop/switch region; other site 298653013336 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 298653013337 catalytic core [active] 298653013338 Oligomerisation domain; Region: Oligomerisation; pfam02410 298653013339 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 298653013340 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 298653013341 active site 298653013342 (T/H)XGH motif; other site 298653013343 short chain dehydrogenase; Validated; Region: PRK08264 298653013344 glucose-1-dehydrogenase; Provisional; Region: PRK08936 298653013345 NAD(P) binding site [chemical binding]; other site 298653013346 active site 298653013347 Predicted transcriptional regulators [Transcription]; Region: COG1733 298653013348 phosphoglucomutase; Validated; Region: PRK07564 298653013349 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 298653013350 active site 298653013351 substrate binding site [chemical binding]; other site 298653013352 metal binding site [ion binding]; metal-binding site 298653013353 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 298653013354 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 298653013355 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 298653013356 active site 298653013357 metal binding site [ion binding]; metal-binding site 298653013358 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 298653013359 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 298653013360 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 298653013361 MoxR-like ATPases [General function prediction only]; Region: COG0714 298653013362 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653013363 Walker A motif; other site 298653013364 ATP binding site [chemical binding]; other site 298653013365 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 298653013366 putative catalytic cysteine [active] 298653013367 gamma-glutamyl kinase; Provisional; Region: PRK05429 298653013368 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 298653013369 nucleotide binding site [chemical binding]; other site 298653013370 homotetrameric interface [polypeptide binding]; other site 298653013371 putative phosphate binding site [ion binding]; other site 298653013372 putative allosteric binding site; other site 298653013373 PUA domain; Region: PUA; pfam01472 298653013374 GTPase CgtA; Reviewed; Region: obgE; PRK12296 298653013375 GTP1/OBG; Region: GTP1_OBG; pfam01018 298653013376 Obg GTPase; Region: Obg; cd01898 298653013377 G1 box; other site 298653013378 GTP/Mg2+ binding site [chemical binding]; other site 298653013379 Switch I region; other site 298653013380 G2 box; other site 298653013381 G3 box; other site 298653013382 Switch II region; other site 298653013383 G4 box; other site 298653013384 G5 box; other site 298653013385 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 298653013386 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 298653013387 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 298653013388 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 298653013389 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 298653013390 homodimer interface [polypeptide binding]; other site 298653013391 oligonucleotide binding site [chemical binding]; other site 298653013392 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 298653013393 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 298653013394 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 298653013395 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 298653013396 B12 binding site [chemical binding]; other site 298653013397 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 298653013398 FeS/SAM binding site; other site 298653013399 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 298653013400 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 298653013401 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 298653013402 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 298653013403 rod shape-determining protein MreC; Provisional; Region: PRK13922 298653013404 rod shape-determining protein MreC; Region: MreC; pfam04085 298653013405 rod shape-determining protein MreB; Provisional; Region: PRK13927 298653013406 MreB and similar proteins; Region: MreB_like; cd10225 298653013407 nucleotide binding site [chemical binding]; other site 298653013408 Mg binding site [ion binding]; other site 298653013409 putative protofilament interaction site [polypeptide binding]; other site 298653013410 RodZ interaction site [polypeptide binding]; other site 298653013411 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 298653013412 active site 298653013413 multimer interface [polypeptide binding]; other site 298653013414 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 298653013415 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 298653013416 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 298653013417 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 298653013418 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 298653013419 Walker A motif; other site 298653013420 ATP binding site [chemical binding]; other site 298653013421 Walker B motif; other site 298653013422 arginine finger; other site 298653013423 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 298653013424 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 298653013425 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 298653013426 oligomer interface [polypeptide binding]; other site 298653013427 active site residues [active] 298653013428 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 298653013429 Clp protease; Region: CLP_protease; pfam00574 298653013430 oligomer interface [polypeptide binding]; other site 298653013431 active site residues [active] 298653013432 trigger factor; Provisional; Region: tig; PRK01490 298653013433 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 298653013434 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 298653013435 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 298653013436 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 298653013437 Methyltransferase domain; Region: Methyltransf_23; pfam13489 298653013438 Methyltransferase domain; Region: Methyltransf_12; pfam08242 298653013439 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 298653013440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 298653013441 Peptidase family M48; Region: Peptidase_M48; cl12018 298653013442 Penicillinase repressor; Region: Pencillinase_R; pfam03965 298653013443 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 298653013444 DNA binding residues [nucleotide binding] 298653013445 TOBE domain; Region: TOBE_2; cl01440 298653013446 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 298653013447 active site 298653013448 FMN binding site [chemical binding]; other site 298653013449 substrate binding site [chemical binding]; other site 298653013450 catalytic residues [active] 298653013451 homodimer interface [polypeptide binding]; other site 298653013452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653013453 Major Facilitator Superfamily; Region: MFS_1; pfam07690 298653013454 putative substrate translocation pore; other site 298653013455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653013456 Major Facilitator Superfamily; Region: MFS_1; pfam07690 298653013457 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 298653013458 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653013459 Protein of unknown function (DUF962); Region: DUF962; pfam06127 298653013460 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 298653013461 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 298653013462 phosphopeptide binding site; other site 298653013463 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 298653013464 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 298653013465 phosphopeptide binding site; other site 298653013466 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 298653013467 ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR). DR is a well-described phenomenon occurring in fungi and shares several similarities with processes...; Region: ABCG_EPDR; cd03213 298653013468 Walker A/P-loop; other site 298653013469 ATP binding site [chemical binding]; other site 298653013470 Q-loop/lid; other site 298653013471 ABC transporter signature motif; other site 298653013472 Walker B; other site 298653013473 D-loop; other site 298653013474 H-loop/switch region; other site 298653013475 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 298653013476 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 298653013477 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 298653013478 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 298653013479 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 298653013480 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 298653013481 putative catalytic site [active] 298653013482 putative metal binding site [ion binding]; other site 298653013483 putative phosphate binding site [ion binding]; other site 298653013484 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 298653013485 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 298653013486 putative dimer interface [polypeptide binding]; other site 298653013487 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 298653013488 CHASE3 domain; Region: CHASE3; pfam05227 298653013489 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 298653013490 dimerization interface [polypeptide binding]; other site 298653013491 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 298653013492 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 298653013493 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 298653013494 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 298653013495 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653013496 Walker A/P-loop; other site 298653013497 ATP binding site [chemical binding]; other site 298653013498 Q-loop/lid; other site 298653013499 ABC transporter signature motif; other site 298653013500 Walker B; other site 298653013501 D-loop; other site 298653013502 H-loop/switch region; other site 298653013503 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 298653013504 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 298653013505 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 298653013506 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 298653013507 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 298653013508 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 298653013509 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 298653013510 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 298653013511 active site 298653013512 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 298653013513 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 298653013514 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 298653013515 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 298653013516 Domain of unknown function DUF20; Region: UPF0118; pfam01594 298653013517 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 298653013518 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 298653013519 Zn binding site [ion binding]; other site 298653013520 Repair protein; Region: Repair_PSII; pfam04536 298653013521 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 298653013522 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 298653013523 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 298653013524 dimerization interface [polypeptide binding]; other site 298653013525 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 298653013526 dimer interface [polypeptide binding]; other site 298653013527 phosphorylation site [posttranslational modification] 298653013528 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653013529 ATP binding site [chemical binding]; other site 298653013530 Mg2+ binding site [ion binding]; other site 298653013531 G-X-G motif; other site 298653013532 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 298653013533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653013534 active site 298653013535 phosphorylation site [posttranslational modification] 298653013536 intermolecular recognition site; other site 298653013537 dimerization interface [polypeptide binding]; other site 298653013538 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 298653013539 DNA binding site [nucleotide binding] 298653013540 Mechanosensitive ion channel; Region: MS_channel; pfam00924 298653013541 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 298653013542 active site 298653013543 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 298653013544 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 298653013545 putative NAD(P) binding site [chemical binding]; other site 298653013546 putative active site [active] 298653013547 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 298653013548 GAF domain; Region: GAF_2; pfam13185 298653013549 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 298653013550 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 298653013551 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 298653013552 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 298653013553 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 298653013554 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 298653013555 active site 298653013556 catalytic site [active] 298653013557 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 298653013558 apolar tunnel; other site 298653013559 heme binding site [chemical binding]; other site 298653013560 dimerization interface [polypeptide binding]; other site 298653013561 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 298653013562 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 298653013563 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 298653013564 ABC transporter; Region: ABC_tran_2; pfam12848 298653013565 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 298653013566 Uncharacterized conserved protein [Function unknown]; Region: COG5361 298653013567 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 298653013568 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 298653013569 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 298653013570 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 298653013571 dimer interface [polypeptide binding]; other site 298653013572 ssDNA binding site [nucleotide binding]; other site 298653013573 tetramer (dimer of dimers) interface [polypeptide binding]; other site 298653013574 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 298653013575 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 298653013576 active site 298653013577 catalytic tetrad [active] 298653013578 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 298653013579 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 298653013580 Int/Topo IB signature motif; other site 298653013581 Frankia-40 domain; Region: Frankia_40_dom; TIGR03917 298653013582 Helix-turn-helix domain; Region: HTH_17; pfam12728 298653013583 Duplicated domain in the epidermal growth factor- and elongation factor-1alpha-binding protein Zpr1. Also present in archaeal proteins; Region: Zpr1; smart00709 298653013584 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653013585 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 298653013586 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 298653013587 non-specific DNA binding site [nucleotide binding]; other site 298653013588 salt bridge; other site 298653013589 sequence-specific DNA binding site [nucleotide binding]; other site 298653013590 Frankia-40 domain; Region: Frankia_40_dom; TIGR03917 298653013591 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 298653013592 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653013593 non-specific DNA binding site [nucleotide binding]; other site 298653013594 salt bridge; other site 298653013595 sequence-specific DNA binding site [nucleotide binding]; other site 298653013596 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 298653013597 nudix motif; other site 298653013598 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 298653013599 Caspase domain; Region: Peptidase_C14; pfam00656 298653013600 Restriction endonuclease; Region: Mrr_cat; pfam04471 298653013601 TIR domain; Region: TIR_2; pfam13676 298653013602 AAA ATPase domain; Region: AAA_16; pfam13191 298653013603 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 298653013604 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 298653013605 Walker A/P-loop; other site 298653013606 ATP binding site [chemical binding]; other site 298653013607 Q-loop/lid; other site 298653013608 ABC transporter signature motif; other site 298653013609 Walker B; other site 298653013610 D-loop; other site 298653013611 H-loop/switch region; other site 298653013612 TOBE domain; Region: TOBE_2; pfam08402 298653013613 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 298653013614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653013615 dimer interface [polypeptide binding]; other site 298653013616 conserved gate region; other site 298653013617 putative PBP binding loops; other site 298653013618 ABC-ATPase subunit interface; other site 298653013619 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 298653013620 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 298653013621 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 298653013622 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653013623 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 298653013624 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 298653013625 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 298653013626 NADH(P)-binding; Region: NAD_binding_10; pfam13460 298653013627 NAD binding site [chemical binding]; other site 298653013628 substrate binding site [chemical binding]; other site 298653013629 putative active site [active] 298653013630 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653013631 NAD(P) binding site [chemical binding]; other site 298653013632 active site 298653013633 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 298653013634 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 298653013635 conserved cys residue [active] 298653013636 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 298653013637 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 298653013638 CHAT domain; Region: CHAT; pfam12770 298653013639 acyl carrier protein; Provisional; Region: acpP; PRK00982 298653013640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653013641 S-adenosylmethionine binding site [chemical binding]; other site 298653013642 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 298653013643 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 298653013644 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 298653013645 DNA binding residues [nucleotide binding] 298653013646 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 298653013647 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 298653013648 YCII-related domain; Region: YCII; cl00999 298653013649 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 298653013650 ERCC4 domain; Region: ERCC4; smart00891 298653013651 Lsr2; Region: Lsr2; pfam11774 298653013652 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 298653013653 MarR family; Region: MarR; pfam01047 298653013654 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 298653013655 catalytic triad [active] 298653013656 conserved cis-peptide bond; other site 298653013657 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 298653013658 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653013659 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 298653013660 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 298653013661 ABC-2 type transporter; Region: ABC2_membrane; cl11417 298653013662 Fic/DOC family; Region: Fic; cl00960 298653013663 SpaB C-terminal domain; Region: SpaB_C; cl14828 298653013664 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653013665 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653013666 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653013667 short chain dehydrogenase; Provisional; Region: PRK06197 298653013668 NAD(P) binding site [chemical binding]; other site 298653013669 active site 298653013670 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 298653013671 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 298653013672 active site 298653013673 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653013674 NAD(P) binding site [chemical binding]; other site 298653013675 active site 298653013676 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653013677 hypothetical protein; Provisional; Region: PRK07538 298653013678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653013679 Cupin; Region: Cupin_6; pfam12852 298653013680 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 298653013681 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 298653013682 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 298653013683 Transposase; Region: DEDD_Tnp_IS110; pfam01548 298653013684 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 298653013685 Helix-turn-helix domain; Region: HTH_18; pfam12833 298653013686 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 298653013687 Amidohydrolase; Region: Amidohydro_2; pfam04909 298653013688 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653013689 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653013690 classical (c) SDRs; Region: SDR_c; cd05233 298653013691 NAD(P) binding site [chemical binding]; other site 298653013692 active site 298653013693 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653013694 Domain of unknown function (DUF385); Region: DUF385; pfam04075 298653013695 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 298653013696 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 298653013697 NAD binding site [chemical binding]; other site 298653013698 catalytic residues [active] 298653013699 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 298653013700 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 298653013701 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 298653013702 NAD binding site [chemical binding]; other site 298653013703 catalytic Zn binding site [ion binding]; other site 298653013704 structural Zn binding site [ion binding]; other site 298653013705 Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755 298653013706 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 298653013707 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 298653013708 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 298653013709 Int/Topo IB signature motif; other site 298653013710 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 298653013711 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 298653013712 ABC-2 type transporter; Region: ABC2_membrane; cl11417 298653013713 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 298653013714 FAD binding domain; Region: FAD_binding_4; pfam01565 298653013715 Berberine and berberine like; Region: BBE; pfam08031 298653013716 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 298653013717 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 298653013718 active site 298653013719 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 298653013720 Histidine kinase; Region: HisKA_3; pfam07730 298653013721 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 298653013722 ATP binding site [chemical binding]; other site 298653013723 Mg2+ binding site [ion binding]; other site 298653013724 G-X-G motif; other site 298653013725 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653013726 ABC transporter signature motif; other site 298653013727 Walker B; other site 298653013728 D-loop; other site 298653013729 H-loop/switch region; other site 298653013730 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653013731 Walker A/P-loop; other site 298653013732 ATP binding site [chemical binding]; other site 298653013733 H+ Antiporter protein; Region: 2A0121; TIGR00900 298653013734 MAPEG family; Region: MAPEG; pfam01124 298653013735 glutathione synthetase; Provisional; Region: PRK05246 298653013736 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 298653013737 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 298653013738 AAA ATPase domain; Region: AAA_16; pfam13191 298653013739 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653013740 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653013741 DNA binding residues [nucleotide binding] 298653013742 dimerization interface [polypeptide binding]; other site 298653013743 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 298653013744 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 298653013745 DDE superfamily endonuclease; Region: DDE_5; cl02413 298653013746 PQQ-like domain; Region: PQQ_2; pfam13360 298653013747 Fic/DOC family; Region: Fic; cl00960 298653013748 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 298653013749 AAA-like domain; Region: AAA_10; pfam12846 298653013750 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 298653013751 Nuclease-related domain; Region: NERD; pfam08378 298653013752 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 298653013753 active site 298653013754 ATP binding site [chemical binding]; other site 298653013755 substrate binding site [chemical binding]; other site 298653013756 activation loop (A-loop); other site 298653013757 Protein kinase domain; Region: Pkinase; pfam00069 298653013758 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653013759 active site 298653013760 ATP binding site [chemical binding]; other site 298653013761 substrate binding site [chemical binding]; other site 298653013762 activation loop (A-loop); other site 298653013763 DEAD-like helicases superfamily; Region: DEXDc; smart00487 298653013764 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 298653013765 ATP binding site [chemical binding]; other site 298653013766 putative Mg++ binding site [ion binding]; other site 298653013767 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 298653013768 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 298653013769 nucleotide binding region [chemical binding]; other site 298653013770 ATP-binding site [chemical binding]; other site 298653013771 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 298653013772 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 298653013773 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 298653013774 ATP binding site [chemical binding]; other site 298653013775 putative Mg++ binding site [ion binding]; other site 298653013776 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 298653013777 nucleotide binding region [chemical binding]; other site 298653013778 ATP-binding site [chemical binding]; other site 298653013779 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 298653013780 Family description; Region: UvrD_C_2; pfam13538 298653013781 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653013782 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653013783 active site 298653013784 ATP binding site [chemical binding]; other site 298653013785 substrate binding site [chemical binding]; other site 298653013786 activation loop (A-loop); other site 298653013787 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 298653013788 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 298653013789 catalytic residue [active] 298653013790 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 298653013791 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653013792 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 298653013793 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 298653013794 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653013795 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 298653013796 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 298653013797 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 298653013798 catalytic residues [active] 298653013799 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 298653013800 Active_site [active] 298653013801 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 298653013802 putative RNAase interaction site [polypeptide binding]; other site 298653013803 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 298653013804 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 298653013805 YwqJ-like deaminase; Region: YwqJ-deaminase; pfam14431 298653013806 Domain of unknown function DUF87; Region: DUF87; pfam01935 298653013807 AAA-like domain; Region: AAA_10; pfam12846 298653013808 MEKHLA domain; Region: MEKHLA; pfam08670 298653013809 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 298653013810 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 298653013811 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 298653013812 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 298653013813 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 298653013814 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 298653013815 active site 298653013816 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653013817 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 298653013818 cofactor binding site; other site 298653013819 metal binding site [ion binding]; metal-binding site 298653013820 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 298653013821 AAA ATPase domain; Region: AAA_16; pfam13191 298653013822 Hemerythrin-like domain; Region: Hr-like; cd12108 298653013823 Fe binding site [ion binding]; other site 298653013824 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 298653013825 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 298653013826 DNA-binding site [nucleotide binding]; DNA binding site 298653013827 RNA-binding motif; other site 298653013828 AAA domain; Region: AAA_17; pfam13207 298653013829 active site 298653013830 Methyltransferase domain; Region: Methyltransf_25; pfam13649 298653013831 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 298653013832 Predicted ATPase [General function prediction only]; Region: COG3903 298653013833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653013834 Helix-turn-helix domain; Region: HTH_31; pfam13560 298653013835 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 298653013836 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 298653013837 Walker A/P-loop; other site 298653013838 ATP binding site [chemical binding]; other site 298653013839 Q-loop/lid; other site 298653013840 ABC transporter signature motif; other site 298653013841 Walker B; other site 298653013842 D-loop; other site 298653013843 H-loop/switch region; other site 298653013844 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 298653013845 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 298653013846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653013847 dimer interface [polypeptide binding]; other site 298653013848 conserved gate region; other site 298653013849 putative PBP binding loops; other site 298653013850 ABC-ATPase subunit interface; other site 298653013851 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 298653013852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653013853 dimer interface [polypeptide binding]; other site 298653013854 conserved gate region; other site 298653013855 putative PBP binding loops; other site 298653013856 ABC-ATPase subunit interface; other site 298653013857 beta-galactosidase; Region: BGL; TIGR03356 298653013858 Transcriptional regulators [Transcription]; Region: PurR; COG1609 298653013859 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 298653013860 DNA binding site [nucleotide binding] 298653013861 domain linker motif; other site 298653013862 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 298653013863 putative dimerization interface [polypeptide binding]; other site 298653013864 putative ligand binding site [chemical binding]; other site 298653013865 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 298653013866 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 298653013867 ATP binding site [chemical binding]; other site 298653013868 putative Mg++ binding site [ion binding]; other site 298653013869 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 298653013870 nucleotide binding region [chemical binding]; other site 298653013871 ATP-binding site [chemical binding]; other site 298653013872 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 298653013873 HRDC domain; Region: HRDC; pfam00570 298653013874 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 298653013875 Bacterial transcriptional activator domain; Region: BTAD; smart01043 298653013876 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 298653013877 putative carbohydrate binding site [chemical binding]; other site 298653013878 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 298653013879 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 298653013880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653013881 ATP binding site [chemical binding]; other site 298653013882 Mg2+ binding site [ion binding]; other site 298653013883 G-X-G motif; other site 298653013884 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 298653013885 Protein of unknown function (DUF742); Region: DUF742; pfam05331 298653013886 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 298653013887 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 298653013888 G1 box; other site 298653013889 GTP/Mg2+ binding site [chemical binding]; other site 298653013890 G2 box; other site 298653013891 Switch I region; other site 298653013892 G3 box; other site 298653013893 Switch II region; other site 298653013894 G4 box; other site 298653013895 G5 box; other site 298653013896 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 298653013897 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 298653013898 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 298653013899 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 298653013900 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 298653013901 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653013902 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 298653013903 salt bridge; other site 298653013904 non-specific DNA binding site [nucleotide binding]; other site 298653013905 sequence-specific DNA binding site [nucleotide binding]; other site 298653013906 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 298653013907 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 298653013908 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653013909 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653013910 active site 298653013911 ATP binding site [chemical binding]; other site 298653013912 substrate binding site [chemical binding]; other site 298653013913 activation loop (A-loop); other site 298653013914 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 298653013915 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 298653013916 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 298653013917 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 298653013918 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 298653013919 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 298653013920 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 298653013921 Predicted transcriptional regulators [Transcription]; Region: COG1733 298653013922 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 298653013923 catalytic residues [active] 298653013924 dimer interface [polypeptide binding]; other site 298653013925 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 298653013926 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 298653013927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653013928 ATP binding site [chemical binding]; other site 298653013929 Mg2+ binding site [ion binding]; other site 298653013930 G-X-G motif; other site 298653013931 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 298653013932 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 298653013933 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653013934 G2 box; other site 298653013935 Switch I region; other site 298653013936 G3 box; other site 298653013937 Switch II region; other site 298653013938 G4 box; other site 298653013939 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653013940 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653013941 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653013942 active site 298653013943 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 298653013944 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653013945 active site 298653013946 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 298653013947 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 298653013948 RNA binding site [nucleotide binding]; other site 298653013949 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 298653013950 RNA binding site [nucleotide binding]; other site 298653013951 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 298653013952 RNA binding site [nucleotide binding]; other site 298653013953 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 298653013954 RNA binding site [nucleotide binding]; other site 298653013955 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 298653013956 Acyltransferase family; Region: Acyl_transf_3; pfam01757 298653013957 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 298653013958 Acyltransferase family; Region: Acyl_transf_3; pfam01757 298653013959 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 298653013960 oxyanion hole [active] 298653013961 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 298653013962 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 298653013963 NADP-binding site; other site 298653013964 homotetramer interface [polypeptide binding]; other site 298653013965 substrate binding site [chemical binding]; other site 298653013966 homodimer interface [polypeptide binding]; other site 298653013967 active site 298653013968 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 298653013969 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 298653013970 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 298653013971 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 298653013972 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 298653013973 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 298653013974 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 298653013975 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 298653013976 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 298653013977 ligand binding site [chemical binding]; other site 298653013978 flexible hinge region; other site 298653013979 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 298653013980 Pirin-related protein [General function prediction only]; Region: COG1741 298653013981 Pirin; Region: Pirin; pfam02678 298653013982 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 298653013983 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 298653013984 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 298653013985 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 298653013986 Walker A motif; other site 298653013987 ATP binding site [chemical binding]; other site 298653013988 Walker B motif; other site 298653013989 arginine finger; other site 298653013990 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 298653013991 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 298653013992 catalytic site [active] 298653013993 putative active site [active] 298653013994 putative substrate binding site [chemical binding]; other site 298653013995 dimer interface [polypeptide binding]; other site 298653013996 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653013997 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653013998 active site 298653013999 phosphorylation site [posttranslational modification] 298653014000 intermolecular recognition site; other site 298653014001 dimerization interface [polypeptide binding]; other site 298653014002 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653014003 DNA binding residues [nucleotide binding] 298653014004 dimerization interface [polypeptide binding]; other site 298653014005 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 298653014006 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 298653014007 NAD(P) binding site [chemical binding]; other site 298653014008 catalytic residues [active] 298653014009 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 298653014010 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 298653014011 NodB motif; other site 298653014012 putative active site [active] 298653014013 putative catalytic site [active] 298653014014 putative Zn binding site [ion binding]; other site 298653014015 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 298653014016 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 298653014017 putative active site [active] 298653014018 putative active site [active] 298653014019 catalytic site [active] 298653014020 catalytic site [active] 298653014021 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 298653014022 active site 298653014023 catalytic triad [active] 298653014024 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 298653014025 Int/Topo IB signature motif; other site 298653014026 Frankia-40 domain; Region: Frankia_40_dom; TIGR03917 298653014027 Helix-turn-helix domain; Region: HTH_17; cl17695 298653014028 DNA binding domain, excisionase family; Region: excise; TIGR01764 298653014029 DNA binding residues [nucleotide binding] 298653014030 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653014031 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 298653014032 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 298653014033 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 298653014034 non-specific DNA binding site [nucleotide binding]; other site 298653014035 salt bridge; other site 298653014036 sequence-specific DNA binding site [nucleotide binding]; other site 298653014037 Frankia-40 domain; Region: Frankia_40_dom; TIGR03917 298653014038 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 298653014039 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653014040 non-specific DNA binding site [nucleotide binding]; other site 298653014041 salt bridge; other site 298653014042 sequence-specific DNA binding site [nucleotide binding]; other site 298653014043 Protein of unknown function DUF262; Region: DUF262; pfam03235 298653014044 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 298653014045 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 298653014046 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 298653014047 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 298653014048 Int/Topo IB signature motif; other site 298653014049 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 298653014050 Frankia-40 domain; Region: Frankia_40_dom; TIGR03917 298653014051 Helix-turn-helix domain; Region: HTH_17; pfam12728 298653014052 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653014053 non-specific DNA binding site [nucleotide binding]; other site 298653014054 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 298653014055 salt bridge; other site 298653014056 sequence-specific DNA binding site [nucleotide binding]; other site 298653014057 Frankia-40 domain; Region: Frankia_40_dom; TIGR03917 298653014058 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653014059 non-specific DNA binding site [nucleotide binding]; other site 298653014060 salt bridge; other site 298653014061 sequence-specific DNA binding site [nucleotide binding]; other site 298653014062 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 298653014063 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 298653014064 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 298653014065 active site 298653014066 NTP binding site [chemical binding]; other site 298653014067 metal binding triad [ion binding]; metal-binding site 298653014068 antibiotic binding site [chemical binding]; other site 298653014069 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 298653014070 Coenzyme A binding pocket [chemical binding]; other site 298653014071 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 298653014072 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 298653014073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653014074 S-adenosylmethionine binding site [chemical binding]; other site 298653014075 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 298653014076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653014077 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 298653014078 putative substrate translocation pore; other site 298653014079 patatin-related protein; Region: TIGR03607 298653014080 Patatin-like phospholipase; Region: Patatin; pfam01734 298653014081 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 298653014082 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 298653014083 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 298653014084 Pollen allergen; Region: Pollen_allerg_1; cl08320 298653014085 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 298653014086 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 298653014087 ligand binding site [chemical binding]; other site 298653014088 flexible hinge region; other site 298653014089 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 298653014090 substrate binding pocket [chemical binding]; other site 298653014091 substrate-Mg2+ binding site; other site 298653014092 aspartate-rich region 1; other site 298653014093 aspartate-rich region 2; other site 298653014094 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 298653014095 substrate binding pocket [chemical binding]; other site 298653014096 substrate-Mg2+ binding site; other site 298653014097 aspartate-rich region 1; other site 298653014098 aspartate-rich region 2; other site 298653014099 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653014100 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 298653014101 putative ligand binding site [chemical binding]; other site 298653014102 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 298653014103 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 298653014104 Walker A/P-loop; other site 298653014105 ATP binding site [chemical binding]; other site 298653014106 Q-loop/lid; other site 298653014107 ABC transporter signature motif; other site 298653014108 Walker B; other site 298653014109 D-loop; other site 298653014110 H-loop/switch region; other site 298653014111 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 298653014112 TM-ABC transporter signature motif; other site 298653014113 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 298653014114 TM-ABC transporter signature motif; other site 298653014115 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 298653014116 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 298653014117 Walker A/P-loop; other site 298653014118 ATP binding site [chemical binding]; other site 298653014119 Q-loop/lid; other site 298653014120 ABC transporter signature motif; other site 298653014121 Walker B; other site 298653014122 D-loop; other site 298653014123 H-loop/switch region; other site 298653014124 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 298653014125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653014126 Methyltransferase domain; Region: Methyltransf_23; pfam13489 298653014127 S-adenosylmethionine binding site [chemical binding]; other site 298653014128 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 298653014129 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 298653014130 homodimer interface [polypeptide binding]; other site 298653014131 active site 298653014132 TDP-binding site; other site 298653014133 acceptor substrate-binding pocket; other site 298653014134 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 298653014135 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 298653014136 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 298653014137 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 298653014138 active site 298653014139 metal binding site [ion binding]; metal-binding site 298653014140 nudix motif; other site 298653014141 Methyltransferase domain; Region: Methyltransf_11; pfam08241 298653014142 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653014143 active site 298653014144 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 298653014145 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 298653014146 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 298653014147 active site 298653014148 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 298653014149 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 298653014150 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 298653014151 Iron-sulfur binding Ferredoxin Reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with a C-terminal iron-sulfur binding cluster domain. FNR was intially identified as a chloroplast reductase activity catalyzing the electron...; Region: FNR_iron_sulfur_binding; cd06191 298653014152 FAD binding pocket [chemical binding]; other site 298653014153 FAD binding motif [chemical binding]; other site 298653014154 phosphate binding motif [ion binding]; other site 298653014155 beta-alpha-beta structure motif; other site 298653014156 NAD binding pocket [chemical binding]; other site 298653014157 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 298653014158 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 298653014159 Moco binding site; other site 298653014160 metal coordination site [ion binding]; other site 298653014161 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 298653014162 nudix motif; other site 298653014163 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653014164 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 298653014165 putative ligand binding site [chemical binding]; other site 298653014166 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 298653014167 FAD binding domain; Region: FAD_binding_4; pfam01565 298653014168 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 298653014169 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 298653014170 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 298653014171 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653014172 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 298653014173 Walker A/P-loop; other site 298653014174 ATP binding site [chemical binding]; other site 298653014175 Q-loop/lid; other site 298653014176 ABC transporter signature motif; other site 298653014177 Walker B; other site 298653014178 D-loop; other site 298653014179 H-loop/switch region; other site 298653014180 Part of AAA domain; Region: AAA_19; pfam13245 298653014181 Family description; Region: UvrD_C_2; pfam13538 298653014182 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 298653014183 intracellular protease, PfpI family; Region: PfpI; TIGR01382 298653014184 proposed catalytic triad [active] 298653014185 conserved cys residue [active] 298653014186 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 298653014187 minor groove reading motif; other site 298653014188 helix-hairpin-helix signature motif; other site 298653014189 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653014190 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653014191 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653014192 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653014193 active site 298653014194 Homeodomain-like domain; Region: HTH_23; pfam13384 298653014195 Winged helix-turn helix; Region: HTH_29; pfam13551 298653014196 Homeodomain-like domain; Region: HTH_32; pfam13565 298653014197 DDE superfamily endonuclease; Region: DDE_3; pfam13358 298653014198 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653014199 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653014200 active site 298653014201 ATP binding site [chemical binding]; other site 298653014202 substrate binding site [chemical binding]; other site 298653014203 activation loop (A-loop); other site 298653014204 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 298653014205 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 298653014206 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 298653014207 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 298653014208 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 298653014209 phosphopeptide binding site; other site 298653014210 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 298653014211 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 298653014212 phosphopeptide binding site; other site 298653014213 ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR). DR is a well-described phenomenon occurring in fungi and shares several similarities with processes...; Region: ABCG_EPDR; cd03213 298653014214 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 298653014215 Walker A/P-loop; other site 298653014216 ATP binding site [chemical binding]; other site 298653014217 Q-loop/lid; other site 298653014218 ABC transporter signature motif; other site 298653014219 Walker B; other site 298653014220 D-loop; other site 298653014221 H-loop/switch region; other site 298653014222 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 298653014223 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 298653014224 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 298653014225 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653014226 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 298653014227 FAD binding domain; Region: FAD_binding_4; pfam01565 298653014228 glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369 298653014229 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 298653014230 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653014231 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653014232 active site 298653014233 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 298653014234 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653014235 active site 298653014236 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 298653014237 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653014238 mercuric reductase; Validated; Region: PRK06370 298653014239 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 298653014240 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 298653014241 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 298653014242 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 298653014243 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 298653014244 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 298653014245 ThiC-associated domain; Region: ThiC-associated; pfam13667 298653014246 ThiC family; Region: ThiC; pfam01964 298653014247 Methyltransferase domain; Region: Methyltransf_23; pfam13489 298653014248 Methyltransferase domain; Region: Methyltransf_12; pfam08242 298653014249 S-adenosylmethionine binding site [chemical binding]; other site 298653014250 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 298653014251 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 298653014252 active site 298653014253 TDP-binding site; other site 298653014254 acceptor substrate-binding pocket; other site 298653014255 homodimer interface [polypeptide binding]; other site 298653014256 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653014257 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653014258 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 298653014259 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 298653014260 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 298653014261 active site 298653014262 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 298653014263 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 298653014264 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 298653014265 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 298653014266 phosphate binding site [ion binding]; other site 298653014267 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 298653014268 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 298653014269 active site 298653014270 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 298653014271 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 298653014272 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 298653014273 putative NADP binding site [chemical binding]; other site 298653014274 active site 298653014275 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653014276 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653014277 DNA binding residues [nucleotide binding] 298653014278 dimerization interface [polypeptide binding]; other site 298653014279 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653014280 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653014281 DNA binding residues [nucleotide binding] 298653014282 Ion channel; Region: Ion_trans_2; pfam07885 298653014283 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 298653014284 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 298653014285 oligomerisation interface [polypeptide binding]; other site 298653014286 mobile loop; other site 298653014287 roof hairpin; other site 298653014288 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 298653014289 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 298653014290 tellurite resistance protein terB; Region: terB; cd07176 298653014291 putative metal binding site [ion binding]; other site 298653014292 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 298653014293 nudix motif; other site 298653014294 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 298653014295 Predicted integral membrane protein [Function unknown]; Region: COG0392 298653014296 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 298653014297 catalytic core [active] 298653014298 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 298653014299 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 298653014300 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 298653014301 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 298653014302 Cu(I) binding site [ion binding]; other site 298653014303 DoxX; Region: DoxX; cl00976 298653014304 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 298653014305 Thioredoxin; Region: Thioredoxin_4; pfam13462 298653014306 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 298653014307 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 298653014308 catalytic triad [active] 298653014309 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653014310 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653014311 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 298653014312 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 298653014313 active site 298653014314 metal binding site [ion binding]; metal-binding site 298653014315 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653014316 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 298653014317 Coenzyme A binding pocket [chemical binding]; other site 298653014318 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653014319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653014320 active site 298653014321 phosphorylation site [posttranslational modification] 298653014322 intermolecular recognition site; other site 298653014323 dimerization interface [polypeptide binding]; other site 298653014324 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653014325 DNA binding residues [nucleotide binding] 298653014326 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 298653014327 active site 298653014328 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 298653014329 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653014330 glutamate racemase; Provisional; Region: PRK00865 298653014331 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 298653014332 ribonuclease PH; Reviewed; Region: rph; PRK00173 298653014333 Ribonuclease PH; Region: RNase_PH_bact; cd11362 298653014334 hexamer interface [polypeptide binding]; other site 298653014335 active site 298653014336 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 298653014337 active site 298653014338 dimerization interface [polypeptide binding]; other site 298653014339 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 298653014340 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 298653014341 dimer interface [polypeptide binding]; other site 298653014342 pyridoxal 5'-phosphate binding site [chemical binding]; other site 298653014343 catalytic residue [active] 298653014344 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 298653014345 MoaE interaction surface [polypeptide binding]; other site 298653014346 MoeB interaction surface [polypeptide binding]; other site 298653014347 thiocarboxylated glycine; other site 298653014348 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 298653014349 MPN+ (JAMM) motif; other site 298653014350 Zinc-binding site [ion binding]; other site 298653014351 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 298653014352 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 298653014353 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 298653014354 nudix motif; other site 298653014355 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 298653014356 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 298653014357 active site 298653014358 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 298653014359 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653014360 non-specific DNA binding site [nucleotide binding]; other site 298653014361 salt bridge; other site 298653014362 sequence-specific DNA binding site [nucleotide binding]; other site 298653014363 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 298653014364 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653014365 NAD(P) binding site [chemical binding]; other site 298653014366 active site 298653014367 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 298653014368 TM-ABC transporter signature motif; other site 298653014369 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 298653014370 TM-ABC transporter signature motif; other site 298653014371 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 298653014372 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 298653014373 Walker A/P-loop; other site 298653014374 ATP binding site [chemical binding]; other site 298653014375 Q-loop/lid; other site 298653014376 ABC transporter signature motif; other site 298653014377 Walker B; other site 298653014378 D-loop; other site 298653014379 H-loop/switch region; other site 298653014380 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 298653014381 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 298653014382 Walker A/P-loop; other site 298653014383 ATP binding site [chemical binding]; other site 298653014384 Q-loop/lid; other site 298653014385 ABC transporter signature motif; other site 298653014386 Walker B; other site 298653014387 D-loop; other site 298653014388 H-loop/switch region; other site 298653014389 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653014390 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 298653014391 putative ligand binding site [chemical binding]; other site 298653014392 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 298653014393 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653014394 Walker A/P-loop; other site 298653014395 ATP binding site [chemical binding]; other site 298653014396 Q-loop/lid; other site 298653014397 ABC transporter signature motif; other site 298653014398 Walker B; other site 298653014399 D-loop; other site 298653014400 H-loop/switch region; other site 298653014401 Agmatinase-like family; Region: Agmatinase-like; cd09990 298653014402 active site 298653014403 oligomer interface [polypeptide binding]; other site 298653014404 Mn binding site [ion binding]; other site 298653014405 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 298653014406 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 298653014407 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 298653014408 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 298653014409 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 298653014410 active site 298653014411 putative substrate binding pocket [chemical binding]; other site 298653014412 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 298653014413 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 298653014414 catalytic residues [active] 298653014415 catalytic nucleophile [active] 298653014416 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 298653014417 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 298653014418 Probable transposase; Region: OrfB_IS605; pfam01385 298653014419 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 298653014420 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 298653014421 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 298653014422 active site 298653014423 homotetramer interface [polypeptide binding]; other site 298653014424 putative bifunctional allantoicase/OHCU decarboxylase; Provisional; Region: PRK13797 298653014425 Allantoicase repeat; Region: Allantoicase; pfam03561 298653014426 Allantoicase repeat; Region: Allantoicase; pfam03561 298653014427 OHCU decarboxylase; Region: UraD_2; TIGR03180 298653014428 allantoinase; Region: allantoinase; TIGR03178 298653014429 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 298653014430 active site 298653014431 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 298653014432 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 298653014433 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 298653014434 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 298653014435 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 298653014436 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 298653014437 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 298653014438 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 298653014439 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 298653014440 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 298653014441 iron-sulfur cluster [ion binding]; other site 298653014442 [2Fe-2S] cluster binding site [ion binding]; other site 298653014443 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 298653014444 hydrophobic ligand binding site; other site 298653014445 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 298653014446 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 298653014447 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 298653014448 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 298653014449 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 298653014450 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 298653014451 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 298653014452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653014453 dimer interface [polypeptide binding]; other site 298653014454 conserved gate region; other site 298653014455 putative PBP binding loops; other site 298653014456 ABC-ATPase subunit interface; other site 298653014457 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 298653014458 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 298653014459 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 298653014460 Walker A/P-loop; other site 298653014461 ATP binding site [chemical binding]; other site 298653014462 Q-loop/lid; other site 298653014463 ABC transporter signature motif; other site 298653014464 Walker B; other site 298653014465 D-loop; other site 298653014466 H-loop/switch region; other site 298653014467 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 298653014468 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 298653014469 Probable transposase; Region: OrfB_IS605; pfam01385 298653014470 NMT1/THI5 like; Region: NMT1; pfam09084 298653014471 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 298653014472 alpha-gamma subunit interface [polypeptide binding]; other site 298653014473 beta-gamma subunit interface [polypeptide binding]; other site 298653014474 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 298653014475 gamma-beta subunit interface [polypeptide binding]; other site 298653014476 alpha-beta subunit interface [polypeptide binding]; other site 298653014477 urease subunit alpha; Reviewed; Region: ureC; PRK13206 298653014478 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 298653014479 subunit interactions [polypeptide binding]; other site 298653014480 active site 298653014481 flap region; other site 298653014482 Protein of unknown function (DUF552); Region: DUF552; pfam04472 298653014483 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 298653014484 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 298653014485 WHG domain; Region: WHG; pfam13305 298653014486 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653014487 UreD urease accessory protein; Region: UreD; cl00530 298653014488 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 298653014489 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 298653014490 active site 298653014491 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 298653014492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653014493 active site 298653014494 phosphorylation site [posttranslational modification] 298653014495 intermolecular recognition site; other site 298653014496 dimerization interface [polypeptide binding]; other site 298653014497 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 298653014498 DNA binding site [nucleotide binding] 298653014499 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 298653014500 dimerization interface [polypeptide binding]; other site 298653014501 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 298653014502 dimer interface [polypeptide binding]; other site 298653014503 phosphorylation site [posttranslational modification] 298653014504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653014505 ATP binding site [chemical binding]; other site 298653014506 G-X-G motif; other site 298653014507 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 298653014508 active site 298653014509 putative catalytic site [active] 298653014510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653014511 Major Facilitator Superfamily; Region: MFS_1; pfam07690 298653014512 putative substrate translocation pore; other site 298653014513 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653014514 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 298653014515 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 298653014516 FeS/SAM binding site; other site 298653014517 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 298653014518 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 298653014519 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 298653014520 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 298653014521 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 298653014522 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 298653014523 Active site cavity [active] 298653014524 catalytic acid [active] 298653014525 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 298653014526 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 298653014527 substrate binding pocket [chemical binding]; other site 298653014528 chain length determination region; other site 298653014529 substrate-Mg2+ binding site; other site 298653014530 catalytic residues [active] 298653014531 aspartate-rich region 1; other site 298653014532 active site lid residues [active] 298653014533 aspartate-rich region 2; other site 298653014534 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 298653014535 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 298653014536 active site lid residues [active] 298653014537 substrate binding pocket [chemical binding]; other site 298653014538 catalytic residues [active] 298653014539 substrate-Mg2+ binding site; other site 298653014540 aspartate-rich region 1; other site 298653014541 aspartate-rich region 2; other site 298653014542 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 298653014543 active site lid residues [active] 298653014544 substrate binding pocket [chemical binding]; other site 298653014545 catalytic residues [active] 298653014546 substrate-Mg2+ binding site; other site 298653014547 aspartate-rich region 1; other site 298653014548 aspartate-rich region 2; other site 298653014549 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 298653014550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653014551 NAD(P) binding site [chemical binding]; other site 298653014552 active site 298653014553 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 298653014554 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653014555 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653014556 MMPL family; Region: MMPL; pfam03176 298653014557 MMPL family; Region: MMPL; pfam03176 298653014558 hypothetical protein; Provisional; Region: PRK06062 298653014559 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 298653014560 inhibitor-cofactor binding pocket; inhibition site 298653014561 pyridoxal 5'-phosphate binding site [chemical binding]; other site 298653014562 catalytic residue [active] 298653014563 Glycerate kinase family; Region: Gly_kinase; cl00841 298653014564 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 298653014565 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 298653014566 P-loop; other site 298653014567 Magnesium ion binding site [ion binding]; other site 298653014568 TIR domain; Region: TIR_2; pfam13676 298653014569 AAA ATPase domain; Region: AAA_16; pfam13191 298653014570 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653014571 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653014572 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653014573 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653014574 TIR domain; Region: TIR_2; pfam13676 298653014575 FxsC C-terminal domain; Region: FxsC_Cterm; TIGR04276 298653014576 radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269 298653014577 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 298653014578 FeS/SAM binding site; other site 298653014579 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 298653014580 HEXXH motif domain; Region: mod_HExxH; TIGR04267 298653014581 AAA ATPase domain; Region: AAA_16; pfam13191 298653014582 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653014583 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653014584 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653014585 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653014586 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653014587 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 298653014588 binding surface 298653014589 TPR motif; other site 298653014590 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653014591 Tetratricopeptide repeat; Region: TPR_10; pfam13374 298653014592 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 298653014593 TPR motif; other site 298653014594 binding surface 298653014595 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 298653014596 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 298653014597 phenylhydantoinase; Validated; Region: PRK08323 298653014598 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 298653014599 tetramer interface [polypeptide binding]; other site 298653014600 active site 298653014601 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 298653014602 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 298653014603 active site 298653014604 catalytic triad [active] 298653014605 dimer interface [polypeptide binding]; other site 298653014606 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 298653014607 nudix motif; other site 298653014608 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 298653014609 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 298653014610 active site 298653014611 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 298653014612 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 298653014613 active site 298653014614 catalytic site [active] 298653014615 substrate binding site [chemical binding]; other site 298653014616 NlpC/P60 family; Region: NLPC_P60; pfam00877 298653014617 Penicillinase repressor; Region: Pencillinase_R; pfam03965 298653014618 Peptidase family M48; Region: Peptidase_M48; cl12018 298653014619 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 298653014620 NlpC/P60 family; Region: NLPC_P60; pfam00877 298653014621 Domain of unknown function (DUF305); Region: DUF305; pfam03713 298653014622 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 298653014623 Family description; Region: DsbD_2; pfam13386 298653014624 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 298653014625 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 298653014626 metal-binding site [ion binding] 298653014627 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 298653014628 metal-binding site [ion binding] 298653014629 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 298653014630 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 298653014631 metal-binding site [ion binding] 298653014632 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 298653014633 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 298653014634 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 298653014635 DDE superfamily endonuclease; Region: DDE_4; pfam13359 298653014636 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653014637 non-specific DNA binding site [nucleotide binding]; other site 298653014638 salt bridge; other site 298653014639 sequence-specific DNA binding site [nucleotide binding]; other site 298653014640 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653014641 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653014642 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653014643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653014644 putative substrate translocation pore; other site 298653014645 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 298653014646 DNA binding site [nucleotide binding] 298653014647 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 298653014648 seryl-tRNA synthetase; Provisional; Region: PRK05431 298653014649 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 298653014650 motif 1; other site 298653014651 dimer interface [polypeptide binding]; other site 298653014652 active site 298653014653 motif 2; other site 298653014654 motif 3; other site 298653014655 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 298653014656 3-oxoacyl-(acyl carrier protein) synthase II; Provisional; Region: PRK14691 298653014657 dimer interface [polypeptide binding]; other site 298653014658 active site 298653014659 acyl carrier protein; Provisional; Region: acpP; PRK00982 298653014660 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 298653014661 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 298653014662 dimer interface [polypeptide binding]; other site 298653014663 active site 298653014664 CoA binding pocket [chemical binding]; other site 298653014665 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 298653014666 dinuclear metal binding motif [ion binding]; other site 298653014667 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 298653014668 N-terminal and C-terminal aromatase/cyclase domains of Streptomyces rimosus OtcD1 and related domains; Region: OtcD1_ARO-CYC_like; cd08861 298653014669 putative hydrophobic ligand binding site [chemical binding]; other site 298653014670 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 298653014671 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 298653014672 inhibitor-cofactor binding pocket; inhibition site 298653014673 pyridoxal 5'-phosphate binding site [chemical binding]; other site 298653014674 catalytic residue [active] 298653014675 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653014676 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653014677 active site 298653014678 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 298653014679 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 298653014680 NAD(P) binding site [chemical binding]; other site 298653014681 catalytic residues [active] 298653014682 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 298653014683 DDE superfamily endonuclease; Region: DDE_5; cl02413 298653014684 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 298653014685 Domain of unknown function (DUF1476); Region: DUF1476; cl11571 298653014686 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 298653014687 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 298653014688 SnoaL-like domain; Region: SnoaL_2; pfam12680 298653014689 Integrase core domain; Region: rve; cl01316 298653014690 Homeodomain-like domain; Region: HTH_23; pfam13384 298653014691 Winged helix-turn helix; Region: HTH_29; pfam13551 298653014692 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653014693 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 298653014694 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 298653014695 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653014696 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 298653014697 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653014698 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 298653014699 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 298653014700 active site 298653014701 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 298653014702 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 298653014703 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 298653014704 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653014705 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653014706 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 298653014707 NAD(P) binding site [chemical binding]; other site 298653014708 active site 298653014709 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 298653014710 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 298653014711 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653014712 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653014713 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 298653014714 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 298653014715 active site 298653014716 metal binding site [ion binding]; metal-binding site 298653014717 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 298653014718 SmpB-tmRNA interface; other site 298653014719 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 298653014720 FtsX-like permease family; Region: FtsX; pfam02687 298653014721 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 298653014722 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653014723 Walker A/P-loop; other site 298653014724 ATP binding site [chemical binding]; other site 298653014725 Q-loop/lid; other site 298653014726 ABC transporter signature motif; other site 298653014727 Walker B; other site 298653014728 D-loop; other site 298653014729 H-loop/switch region; other site 298653014730 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 298653014731 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 298653014732 Viral (Superfamily 1) RNA helicase; Region: Viral_helicase1; pfam01443 298653014733 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 298653014734 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 298653014735 active site 298653014736 SAM binding site [chemical binding]; other site 298653014737 homodimer interface [polypeptide binding]; other site 298653014738 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 298653014739 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 298653014740 putative active site [active] 298653014741 putative metal binding site [ion binding]; other site 298653014742 peptide chain release factor 2; Validated; Region: prfB; PRK00578 298653014743 This domain is found in peptide chain release factors; Region: PCRF; smart00937 298653014744 RF-1 domain; Region: RF-1; pfam00472 298653014745 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 298653014746 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 298653014747 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 298653014748 molybdopterin cofactor binding site; other site 298653014749 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 298653014750 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 298653014751 molybdopterin cofactor binding site; other site 298653014752 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 298653014753 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 298653014754 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 298653014755 DNA binding residues [nucleotide binding] 298653014756 EthD domain; Region: EthD; pfam07110 298653014757 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653014758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653014759 active site 298653014760 phosphorylation site [posttranslational modification] 298653014761 intermolecular recognition site; other site 298653014762 dimerization interface [polypeptide binding]; other site 298653014763 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653014764 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 298653014765 DNA binding residues [nucleotide binding] 298653014766 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653014767 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653014768 DNA binding residues [nucleotide binding] 298653014769 short chain dehydrogenase; Validated; Region: PRK06182 298653014770 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 298653014771 NADP binding site [chemical binding]; other site 298653014772 active site 298653014773 steroid binding site; other site 298653014774 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653014775 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 298653014776 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 298653014777 homodimer interface [polypeptide binding]; other site 298653014778 active site 298653014779 TDP-binding site; other site 298653014780 acceptor substrate-binding pocket; other site 298653014781 hypothetical protein; Provisional; Region: PRK04233 298653014782 SEC-C motif; Region: SEC-C; pfam02810 298653014783 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 298653014784 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653014785 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653014786 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 298653014787 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653014788 non-specific DNA binding site [nucleotide binding]; other site 298653014789 salt bridge; other site 298653014790 sequence-specific DNA binding site [nucleotide binding]; other site 298653014791 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 298653014792 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 298653014793 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 298653014794 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 298653014795 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 298653014796 ATP binding site [chemical binding]; other site 298653014797 Walker A motif; other site 298653014798 hexamer interface [polypeptide binding]; other site 298653014799 Walker B motif; other site 298653014800 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 298653014801 PAS domain; Region: PAS_9; pfam13426 298653014802 putative active site [active] 298653014803 heme pocket [chemical binding]; other site 298653014804 Uncharacterized conserved protein [Function unknown]; Region: COG3743 298653014805 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 298653014806 nucleophile elbow; other site 298653014807 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 298653014808 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 298653014809 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653014810 non-specific DNA binding site [nucleotide binding]; other site 298653014811 salt bridge; other site 298653014812 sequence-specific DNA binding site [nucleotide binding]; other site 298653014813 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 298653014814 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 298653014815 Helix-turn-helix domain; Region: HTH_17; pfam12728 298653014816 DNA binding residues [nucleotide binding] 298653014817 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 298653014818 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653014819 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 298653014820 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 298653014821 nucleotide binding region [chemical binding]; other site 298653014822 SEC-C motif; Region: SEC-C; pfam02810 298653014823 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 298653014824 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 298653014825 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653014826 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653014827 active site 298653014828 phosphorylation site [posttranslational modification] 298653014829 intermolecular recognition site; other site 298653014830 dimerization interface [polypeptide binding]; other site 298653014831 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653014832 DNA binding residues [nucleotide binding] 298653014833 dimerization interface [polypeptide binding]; other site 298653014834 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 298653014835 30S subunit binding site; other site 298653014836 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 298653014837 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 298653014838 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 298653014839 MoxR-like ATPases [General function prediction only]; Region: COG0714 298653014840 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 298653014841 Walker A motif; other site 298653014842 ATP binding site [chemical binding]; other site 298653014843 Walker B motif; other site 298653014844 arginine finger; other site 298653014845 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 298653014846 Protein of unknown function DUF58; Region: DUF58; pfam01882 298653014847 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 298653014848 RDD family; Region: RDD; pfam06271 298653014849 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 298653014850 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 298653014851 Probable transposase; Region: OrfB_IS605; pfam01385 298653014852 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 298653014853 Transposase IS200 like; Region: Y1_Tnp; pfam01797 298653014854 Integral membrane protein DUF95; Region: DUF95; pfam01944 298653014855 Transglycosylase; Region: Transgly; pfam00912 298653014856 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 298653014857 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 298653014858 Chitin binding domain; Region: Chitin_bind_3; pfam03067 298653014859 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 298653014860 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 298653014861 dimer interface [polypeptide binding]; other site 298653014862 active site 298653014863 Trm112p-like protein; Region: Trm112p; cl01066 298653014864 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 298653014865 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 298653014866 active site 298653014867 substrate binding site [chemical binding]; other site 298653014868 metal binding site [ion binding]; metal-binding site 298653014869 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 298653014870 Possibl zinc metallo-peptidase; Region: DUF1025; pfam06262 298653014871 mannose-6-phosphate isomerase; Region: PLN02288 298653014872 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 298653014873 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 298653014874 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 298653014875 Transcription factor WhiB; Region: Whib; pfam02467 298653014876 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofG subunit; Region: F420_cofG; TIGR03550 298653014877 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 298653014878 FeS/SAM binding site; other site 298653014879 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit; Region: F420_cofH; TIGR03551 298653014880 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 298653014881 FeS/SAM binding site; other site 298653014882 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653014883 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653014884 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 298653014885 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 298653014886 phosphate binding site [ion binding]; other site 298653014887 dimer interface [polypeptide binding]; other site 298653014888 substrate binding site [chemical binding]; other site 298653014889 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 298653014890 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 298653014891 F420 biosynthesis protein FbiB, C-terminal domain; Region: F420_FbiB_CTERM; TIGR03553 298653014892 FMN binding site [chemical binding]; other site 298653014893 dimer interface [polypeptide binding]; other site 298653014894 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 298653014895 DNA polymerase III subunit beta; Validated; Region: PRK07761 298653014896 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 298653014897 putative DNA binding surface [nucleotide binding]; other site 298653014898 dimer interface [polypeptide binding]; other site 298653014899 beta-clamp/clamp loader binding surface; other site 298653014900 beta-clamp/translesion DNA polymerase binding surface; other site 298653014901 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 298653014902 Acyltransferase family; Region: Acyl_transf_3; pfam01757 298653014903 Septum formation; Region: Septum_form; pfam13845 298653014904 Septum formation; Region: Septum_form; pfam13845 298653014905 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 298653014906 N-acetyl-D-glucosamine binding site [chemical binding]; other site 298653014907 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653014908 ATP binding site [chemical binding]; other site 298653014909 Mg2+ binding site [ion binding]; other site 298653014910 G-X-G motif; other site 298653014911 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 298653014912 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 298653014913 active site 298653014914 Substrate binding site; other site 298653014915 Mg++ binding site; other site 298653014916 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 298653014917 putative trimer interface [polypeptide binding]; other site 298653014918 putative CoA binding site [chemical binding]; other site 298653014919 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 298653014920 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 298653014921 Probable Catalytic site; other site 298653014922 metal-binding site 298653014923 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 298653014924 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 298653014925 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 298653014926 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 298653014927 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 298653014928 Methyltransferase domain; Region: Methyltransf_23; pfam13489 298653014929 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653014930 S-adenosylmethionine binding site [chemical binding]; other site 298653014931 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 298653014932 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 298653014933 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 298653014934 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 298653014935 Ligand binding site; other site 298653014936 Putative Catalytic site; other site 298653014937 DXD motif; other site 298653014938 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 298653014939 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 298653014940 active site 298653014941 trimer interface [polypeptide binding]; other site 298653014942 CoA binding site [chemical binding]; other site 298653014943 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 298653014944 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653014945 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653014946 active site 298653014947 ATP binding site [chemical binding]; other site 298653014948 substrate binding site [chemical binding]; other site 298653014949 activation loop (A-loop); other site 298653014950 FOG: WD40 repeat [General function prediction only]; Region: COG2319 298653014951 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 298653014952 structural tetrad; other site 298653014953 Methyltransferase domain; Region: Methyltransf_24; pfam13578 298653014954 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 298653014955 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 298653014956 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 298653014957 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 298653014958 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 298653014959 Walker A/P-loop; other site 298653014960 ATP binding site [chemical binding]; other site 298653014961 Q-loop/lid; other site 298653014962 ABC transporter signature motif; other site 298653014963 Walker B; other site 298653014964 D-loop; other site 298653014965 H-loop/switch region; other site 298653014966 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 298653014967 Probable Catalytic site; other site 298653014968 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 298653014969 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 298653014970 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 298653014971 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 298653014972 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 298653014973 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 298653014974 active site 298653014975 HIGH motif; other site 298653014976 KMSKS motif; other site 298653014977 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 298653014978 tRNA binding surface [nucleotide binding]; other site 298653014979 anticodon binding site; other site 298653014980 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 298653014981 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 298653014982 NADP binding site [chemical binding]; other site 298653014983 active site 298653014984 putative substrate binding site [chemical binding]; other site 298653014985 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 298653014986 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 298653014987 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 298653014988 substrate binding site; other site 298653014989 metal-binding site 298653014990 Oligomer interface; other site 298653014991 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 298653014992 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 298653014993 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 298653014994 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 298653014995 AMP-binding enzyme; Region: AMP-binding; cl15778 298653014996 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 298653014997 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 298653014998 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 298653014999 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 298653015000 active site clefts [active] 298653015001 zinc binding site [ion binding]; other site 298653015002 dimer interface [polypeptide binding]; other site 298653015003 GtrA-like protein; Region: GtrA; pfam04138 298653015004 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653015005 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653015006 Bacterial PH domain; Region: DUF304; pfam03703 298653015007 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 298653015008 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 298653015009 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 298653015010 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 298653015011 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 298653015012 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 298653015013 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 298653015014 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 298653015015 ATP-grasp domain; Region: ATP-grasp_4; cl03087 298653015016 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 298653015017 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 298653015018 carboxyltransferase (CT) interaction site; other site 298653015019 biotinylation site [posttranslational modification]; other site 298653015020 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 298653015021 catalytic core [active] 298653015022 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 298653015023 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 298653015024 Probable transposase; Region: OrfB_IS605; pfam01385 298653015025 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 298653015026 Transposase IS200 like; Region: Y1_Tnp; pfam01797 298653015027 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 298653015028 intersubunit interface [polypeptide binding]; other site 298653015029 active site 298653015030 catalytic residue [active] 298653015031 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 298653015032 active site 298653015033 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 298653015034 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 298653015035 active site 298653015036 substrate binding site [chemical binding]; other site 298653015037 metal binding site [ion binding]; metal-binding site 298653015038 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 298653015039 purine nucleoside phosphorylase; Provisional; Region: PRK08202 298653015040 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 298653015041 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 298653015042 dimer interface [polypeptide binding]; other site 298653015043 anticodon binding site; other site 298653015044 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 298653015045 motif 1; other site 298653015046 dimer interface [polypeptide binding]; other site 298653015047 active site 298653015048 motif 2; other site 298653015049 GAD domain; Region: GAD; pfam02938 298653015050 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 298653015051 active site 298653015052 motif 3; other site 298653015053 carboxylate-amine ligase; Provisional; Region: PRK13517 298653015054 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 298653015055 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 298653015056 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 298653015057 metal binding site [ion binding]; metal-binding site 298653015058 putative dimer interface [polypeptide binding]; other site 298653015059 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 298653015060 putative active site pocket [active] 298653015061 dimerization interface [polypeptide binding]; other site 298653015062 putative catalytic residue [active] 298653015063 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 298653015064 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 298653015065 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 298653015066 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 298653015067 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 298653015068 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 298653015069 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 298653015070 ATP binding site [chemical binding]; other site 298653015071 substrate binding site [chemical binding]; other site 298653015072 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 298653015073 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 298653015074 adenosine deaminase; Provisional; Region: PRK09358 298653015075 active site 298653015076 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 298653015077 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 298653015078 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 298653015079 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 298653015080 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 298653015081 active site 298653015082 catalytic motif [active] 298653015083 Zn binding site [ion binding]; other site 298653015084 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653015085 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653015086 active site 298653015087 ATP binding site [chemical binding]; other site 298653015088 substrate binding site [chemical binding]; other site 298653015089 activation loop (A-loop); other site 298653015090 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 298653015091 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653015092 active site 298653015093 ATP binding site [chemical binding]; other site 298653015094 substrate binding site [chemical binding]; other site 298653015095 activation loop (A-loop); other site 298653015096 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 298653015097 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 298653015098 active site 298653015099 substrate binding site [chemical binding]; other site 298653015100 cosubstrate binding site; other site 298653015101 catalytic site [active] 298653015102 Formyl transferase, C-terminal domain; Region: Formyl_trans_C; pfam02911 298653015103 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 298653015104 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 298653015105 siderophore binding site; other site 298653015106 Condensation domain; Region: Condensation; pfam00668 298653015107 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 298653015108 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 298653015109 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 298653015110 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 298653015111 Condensation domain; Region: Condensation; pfam00668 298653015112 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 298653015113 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 298653015114 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 298653015115 AMP-binding enzyme; Region: AMP-binding; cl15778 298653015116 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 298653015117 Condensation domain; Region: Condensation; pfam00668 298653015118 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 298653015119 Condensation domain; Region: Condensation; pfam00668 298653015120 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 298653015121 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 298653015122 Methyltransferase domain; Region: Methyltransf_12; pfam08242 298653015123 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 298653015124 Condensation domain; Region: Condensation; pfam00668 298653015125 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 298653015126 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 298653015127 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 298653015128 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 298653015129 Condensation domain; Region: Condensation; pfam00668 298653015130 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 298653015131 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 298653015132 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 298653015133 AMP-binding enzyme; Region: AMP-binding; cl15778 298653015134 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 298653015135 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 298653015136 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 298653015137 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653015138 AMP-binding enzyme; Region: AMP-binding; cl15778 298653015139 salicylate synthase; Region: salicyl_syn; TIGR03494 298653015140 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 298653015141 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 298653015142 Condensation domain; Region: Condensation; pfam00668 298653015143 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 298653015144 Nonribosomal peptide synthase; Region: NRPS; pfam08415 298653015145 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 298653015146 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 298653015147 MbtH-like protein; Region: MbtH; pfam03621 298653015148 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 298653015149 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653015150 Walker A/P-loop; other site 298653015151 ATP binding site [chemical binding]; other site 298653015152 Q-loop/lid; other site 298653015153 ABC transporter signature motif; other site 298653015154 Walker B; other site 298653015155 D-loop; other site 298653015156 H-loop/switch region; other site 298653015157 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 298653015158 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 298653015159 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653015160 Walker A/P-loop; other site 298653015161 ATP binding site [chemical binding]; other site 298653015162 Q-loop/lid; other site 298653015163 ABC transporter signature motif; other site 298653015164 Walker B; other site 298653015165 D-loop; other site 298653015166 H-loop/switch region; other site 298653015167 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 298653015168 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 298653015169 ABC-ATPase subunit interface; other site 298653015170 dimer interface [polypeptide binding]; other site 298653015171 putative PBP binding regions; other site 298653015172 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 298653015173 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 298653015174 dimer interface [polypeptide binding]; other site 298653015175 putative PBP binding regions; other site 298653015176 ABC-ATPase subunit interface; other site 298653015177 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 298653015178 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 298653015179 Walker A/P-loop; other site 298653015180 ATP binding site [chemical binding]; other site 298653015181 Q-loop/lid; other site 298653015182 ABC transporter signature motif; other site 298653015183 Walker B; other site 298653015184 D-loop; other site 298653015185 H-loop/switch region; other site 298653015186 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 298653015187 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653015188 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 298653015189 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653015190 DEAD/DEAH box helicase; Region: DEAD; pfam00270 298653015191 putative Mg++ binding site [ion binding]; other site 298653015192 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 298653015193 nucleotide binding region [chemical binding]; other site 298653015194 ATP-binding site [chemical binding]; other site 298653015195 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 298653015196 active site 298653015197 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 298653015198 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 298653015199 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 298653015200 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 298653015201 YcfA-like protein; Region: YcfA; pfam07927 298653015202 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 298653015203 siroheme synthase; Provisional; Region: cysG; PRK10637 298653015204 YcfA-like protein; Region: YcfA; pfam07927 298653015205 Abi-like protein; Region: Abi_2; pfam07751 298653015206 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653015207 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 298653015208 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 298653015209 dimer interface [polypeptide binding]; other site 298653015210 active site 298653015211 metal binding site [ion binding]; metal-binding site 298653015212 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 298653015213 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 298653015214 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 298653015215 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 298653015216 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 298653015217 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 298653015218 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 298653015219 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 298653015220 Beta-lactamase; Region: Beta-lactamase; pfam00144 298653015221 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 298653015222 malate dehydrogenase; Reviewed; Region: PRK06223 298653015223 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 298653015224 NAD(P) binding site [chemical binding]; other site 298653015225 dimer interface [polypeptide binding]; other site 298653015226 tetramer (dimer of dimers) interface [polypeptide binding]; other site 298653015227 substrate binding site [chemical binding]; other site 298653015228 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 298653015229 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 298653015230 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 298653015231 phosphopeptide binding site; other site 298653015232 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653015233 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653015234 DNA binding residues [nucleotide binding] 298653015235 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 298653015236 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 298653015237 active site 298653015238 substrate binding site [chemical binding]; other site 298653015239 cosubstrate binding site; other site 298653015240 catalytic site [active] 298653015241 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 298653015242 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 298653015243 purine monophosphate binding site [chemical binding]; other site 298653015244 dimer interface [polypeptide binding]; other site 298653015245 putative catalytic residues [active] 298653015246 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 298653015247 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 298653015248 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653015249 salt bridge; other site 298653015250 non-specific DNA binding site [nucleotide binding]; other site 298653015251 sequence-specific DNA binding site [nucleotide binding]; other site 298653015252 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 298653015253 CoA binding domain; Region: CoA_binding; smart00881 298653015254 CoA-ligase; Region: Ligase_CoA; cl02894 298653015255 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 298653015256 ATP-grasp domain; Region: ATP-grasp_4; cl03087 298653015257 CoA-ligase; Region: Ligase_CoA; cl02894 298653015258 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653015259 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 298653015260 active site 298653015261 ATP binding site [chemical binding]; other site 298653015262 substrate binding site [chemical binding]; other site 298653015263 activation loop (A-loop); other site 298653015264 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 298653015265 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 298653015266 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 298653015267 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653015268 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 298653015269 Peptidase family M23; Region: Peptidase_M23; pfam01551 298653015270 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653015271 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 298653015272 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 298653015273 catalytic residues [active] 298653015274 catalytic nucleophile [active] 298653015275 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 298653015276 Part of AAA domain; Region: AAA_19; pfam13245 298653015277 Family description; Region: UvrD_C_2; pfam13538 298653015278 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 298653015279 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 298653015280 tetramer interface [polypeptide binding]; other site 298653015281 pyridoxal 5'-phosphate binding site [chemical binding]; other site 298653015282 catalytic residue [active] 298653015283 GMP synthase; Reviewed; Region: guaA; PRK00074 298653015284 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 298653015285 AMP/PPi binding site [chemical binding]; other site 298653015286 candidate oxyanion hole; other site 298653015287 catalytic triad [active] 298653015288 potential glutamine specificity residues [chemical binding]; other site 298653015289 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 298653015290 ATP Binding subdomain [chemical binding]; other site 298653015291 Ligand Binding sites [chemical binding]; other site 298653015292 Dimerization subdomain; other site 298653015293 Nitrate and nitrite sensing; Region: NIT; pfam08376 298653015294 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 298653015295 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653015296 ATP binding site [chemical binding]; other site 298653015297 Mg2+ binding site [ion binding]; other site 298653015298 G-X-G motif; other site 298653015299 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 298653015300 Protein of unknown function (DUF742); Region: DUF742; pfam05331 298653015301 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 298653015302 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 298653015303 G1 box; other site 298653015304 GTP/Mg2+ binding site [chemical binding]; other site 298653015305 G2 box; other site 298653015306 Switch I region; other site 298653015307 G3 box; other site 298653015308 Switch II region; other site 298653015309 G4 box; other site 298653015310 G5 box; other site 298653015311 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653015312 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_4; cd06337 298653015313 putative ligand binding site [chemical binding]; other site 298653015314 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 298653015315 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 298653015316 phosphate binding site [ion binding]; other site 298653015317 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 298653015318 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 298653015319 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 298653015320 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 298653015321 active site 298653015322 Transcription factor WhiB; Region: Whib; pfam02467 298653015323 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 298653015324 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 298653015325 ring oligomerisation interface [polypeptide binding]; other site 298653015326 ATP/Mg binding site [chemical binding]; other site 298653015327 stacking interactions; other site 298653015328 hinge regions; other site 298653015329 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 298653015330 oligomerisation interface [polypeptide binding]; other site 298653015331 mobile loop; other site 298653015332 roof hairpin; other site 298653015333 Helix-turn-helix domains; Region: HTH; cl00088 298653015334 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 298653015335 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 298653015336 UGMP family protein; Validated; Region: PRK09604 298653015337 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 298653015338 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 298653015339 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 298653015340 Coenzyme A binding pocket [chemical binding]; other site 298653015341 universal bacterial protein YeaZ; Region: bact_YeaZ; TIGR03725 298653015342 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653015343 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653015344 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 298653015345 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653015346 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653015347 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653015348 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 298653015349 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 298653015350 active site 298653015351 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 298653015352 substrate binding site [chemical binding]; other site 298653015353 dimer interface [polypeptide binding]; other site 298653015354 catalytic residues [active] 298653015355 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 298653015356 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 298653015357 putative substrate binding site [chemical binding]; other site 298653015358 putative ATP binding site [chemical binding]; other site 298653015359 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 298653015360 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 298653015361 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 298653015362 glutaminase active site [active] 298653015363 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 298653015364 dimer interface [polypeptide binding]; other site 298653015365 active site 298653015366 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 298653015367 dimer interface [polypeptide binding]; other site 298653015368 active site 298653015369 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 298653015370 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 298653015371 active site 298653015372 substrate binding site [chemical binding]; other site 298653015373 metal binding site [ion binding]; metal-binding site 298653015374 Ribosomal protein S9/S16; Region: Ribosomal_S9; pfam00380 298653015375 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 298653015376 23S rRNA interface [nucleotide binding]; other site 298653015377 L3 interface [polypeptide binding]; other site 298653015378 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 298653015379 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 298653015380 dimerization interface 3.5A [polypeptide binding]; other site 298653015381 active site 298653015382 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 298653015383 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 298653015384 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 298653015385 alphaNTD - beta interaction site [polypeptide binding]; other site 298653015386 alphaNTD homodimer interface [polypeptide binding]; other site 298653015387 alphaNTD - beta' interaction site [polypeptide binding]; other site 298653015388 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 298653015389 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 298653015390 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 298653015391 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 298653015392 RNA binding surface [nucleotide binding]; other site 298653015393 30S ribosomal protein S11; Validated; Region: PRK05309 298653015394 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 298653015395 30S ribosomal protein S13; Region: bact_S13; TIGR03631 298653015396 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 298653015397 rRNA binding site [nucleotide binding]; other site 298653015398 predicted 30S ribosome binding site; other site 298653015399 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 298653015400 active site 298653015401 adenylate kinase; Reviewed; Region: adk; PRK00279 298653015402 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 298653015403 AMP-binding site [chemical binding]; other site 298653015404 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 298653015405 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 298653015406 SecY translocase; Region: SecY; pfam00344 298653015407 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 298653015408 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 298653015409 23S rRNA binding site [nucleotide binding]; other site 298653015410 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 298653015411 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 298653015412 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 298653015413 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 298653015414 5S rRNA interface [nucleotide binding]; other site 298653015415 L27 interface [polypeptide binding]; other site 298653015416 23S rRNA interface [nucleotide binding]; other site 298653015417 L5 interface [polypeptide binding]; other site 298653015418 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 298653015419 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 298653015420 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 298653015421 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 298653015422 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 298653015423 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 298653015424 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 298653015425 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 298653015426 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 298653015427 ribosomal protein L24; Validated; Region: rpl24; CHL00141 298653015428 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 298653015429 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 298653015430 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 298653015431 putative translocon interaction site; other site 298653015432 23S rRNA interface [nucleotide binding]; other site 298653015433 signal recognition particle (SRP54) interaction site; other site 298653015434 L23 interface [polypeptide binding]; other site 298653015435 trigger factor interaction site; other site 298653015436 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 298653015437 23S rRNA interface [nucleotide binding]; other site 298653015438 5S rRNA interface [nucleotide binding]; other site 298653015439 putative antibiotic binding site [chemical binding]; other site 298653015440 L25 interface [polypeptide binding]; other site 298653015441 L27 interface [polypeptide binding]; other site 298653015442 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 298653015443 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 298653015444 G-X-X-G motif; other site 298653015445 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 298653015446 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 298653015447 putative translocon binding site; other site 298653015448 protein-rRNA interface [nucleotide binding]; other site 298653015449 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 298653015450 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 298653015451 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 298653015452 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 298653015453 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 298653015454 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 298653015455 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 298653015456 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 298653015457 elongation factor Tu; Reviewed; Region: PRK00049 298653015458 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 298653015459 G1 box; other site 298653015460 GEF interaction site [polypeptide binding]; other site 298653015461 GTP/Mg2+ binding site [chemical binding]; other site 298653015462 Switch I region; other site 298653015463 G2 box; other site 298653015464 G3 box; other site 298653015465 Switch II region; other site 298653015466 G4 box; other site 298653015467 G5 box; other site 298653015468 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 298653015469 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 298653015470 Antibiotic Binding Site [chemical binding]; other site 298653015471 elongation factor G; Reviewed; Region: PRK00007 298653015472 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 298653015473 G1 box; other site 298653015474 putative GEF interaction site [polypeptide binding]; other site 298653015475 GTP/Mg2+ binding site [chemical binding]; other site 298653015476 Switch I region; other site 298653015477 G2 box; other site 298653015478 G3 box; other site 298653015479 Switch II region; other site 298653015480 G4 box; other site 298653015481 G5 box; other site 298653015482 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 298653015483 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 298653015484 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 298653015485 30S ribosomal protein S7; Validated; Region: PRK05302 298653015486 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 298653015487 S17 interaction site [polypeptide binding]; other site 298653015488 S8 interaction site; other site 298653015489 16S rRNA interaction site [nucleotide binding]; other site 298653015490 streptomycin interaction site [chemical binding]; other site 298653015491 23S rRNA interaction site [nucleotide binding]; other site 298653015492 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 298653015493 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 298653015494 active site 298653015495 SUMO-1 interface [polypeptide binding]; other site 298653015496 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 298653015497 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 298653015498 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 298653015499 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 298653015500 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 298653015501 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 298653015502 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 298653015503 G-loop; other site 298653015504 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 298653015505 DNA binding site [nucleotide binding] 298653015506 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 298653015507 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 298653015508 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 298653015509 RPB12 interaction site [polypeptide binding]; other site 298653015510 RPB1 interaction site [polypeptide binding]; other site 298653015511 RPB10 interaction site [polypeptide binding]; other site 298653015512 RPB11 interaction site [polypeptide binding]; other site 298653015513 RPB3 interaction site [polypeptide binding]; other site 298653015514 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 298653015515 core dimer interface [polypeptide binding]; other site 298653015516 peripheral dimer interface [polypeptide binding]; other site 298653015517 L10 interface [polypeptide binding]; other site 298653015518 L11 interface [polypeptide binding]; other site 298653015519 putative EF-Tu interaction site [polypeptide binding]; other site 298653015520 putative EF-G interaction site [polypeptide binding]; other site 298653015521 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 298653015522 23S rRNA interface [nucleotide binding]; other site 298653015523 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 298653015524 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 298653015525 mRNA/rRNA interface [nucleotide binding]; other site 298653015526 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 298653015527 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 298653015528 23S rRNA interface [nucleotide binding]; other site 298653015529 L7/L12 interface [polypeptide binding]; other site 298653015530 putative thiostrepton binding site; other site 298653015531 L25 interface [polypeptide binding]; other site 298653015532 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 298653015533 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 298653015534 putative homodimer interface [polypeptide binding]; other site 298653015535 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 298653015536 aspartate aminotransferase; Provisional; Region: PRK05764 298653015537 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 298653015538 pyridoxal 5'-phosphate binding site [chemical binding]; other site 298653015539 homodimer interface [polypeptide binding]; other site 298653015540 catalytic residue [active] 298653015541 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 298653015542 active site 298653015543 catalytic site [active] 298653015544 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 298653015545 active site 298653015546 catalytic site [active] 298653015547 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 298653015548 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 298653015549 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 298653015550 active site 298653015551 LGFP repeat; Region: LGFP; pfam08310 298653015552 LGFP repeat; Region: LGFP; pfam08310 298653015553 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 298653015554 putative active site pocket [active] 298653015555 dimerization interface [polypeptide binding]; other site 298653015556 putative catalytic residue [active] 298653015557 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 298653015558 active site 298653015559 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 298653015560 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653015561 non-specific DNA binding site [nucleotide binding]; other site 298653015562 salt bridge; other site 298653015563 sequence-specific DNA binding site [nucleotide binding]; other site 298653015564 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 298653015565 heat shock protein HtpX; Provisional; Region: PRK03072 298653015566 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 298653015567 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 298653015568 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 298653015569 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 298653015570 dimer interface [polypeptide binding]; other site 298653015571 PYR/PP interface [polypeptide binding]; other site 298653015572 TPP binding site [chemical binding]; other site 298653015573 substrate binding site [chemical binding]; other site 298653015574 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 298653015575 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 298653015576 TPP-binding site [chemical binding]; other site 298653015577 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 298653015578 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 298653015579 substrate binding pocket [chemical binding]; other site 298653015580 chain length determination region; other site 298653015581 substrate-Mg2+ binding site; other site 298653015582 catalytic residues [active] 298653015583 aspartate-rich region 1; other site 298653015584 active site lid residues [active] 298653015585 aspartate-rich region 2; other site 298653015586 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 298653015587 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 298653015588 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 298653015589 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 298653015590 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 298653015591 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 298653015592 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 298653015593 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 298653015594 NADH-ubiquinone/plastoquinone oxidoreductase chain 6; Region: Oxidored_q3; pfam00499 298653015595 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 298653015596 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 298653015597 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 298653015598 4Fe-4S binding domain; Region: Fer4; pfam00037 298653015599 4Fe-4S binding domain; Region: Fer4; pfam00037 298653015600 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 298653015601 NADH dehydrogenase subunit G; Validated; Region: PRK07860 298653015602 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 298653015603 catalytic loop [active] 298653015604 iron binding site [ion binding]; other site 298653015605 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 298653015606 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 298653015607 molybdopterin cofactor binding site; other site 298653015608 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 298653015609 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 298653015610 SLBB domain; Region: SLBB; pfam10531 298653015611 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 298653015612 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 298653015613 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 298653015614 putative dimer interface [polypeptide binding]; other site 298653015615 [2Fe-2S] cluster binding site [ion binding]; other site 298653015616 NADH dehydrogenase subunit D; Validated; Region: PRK06075 298653015617 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 298653015618 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852 298653015619 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 298653015620 NADH dehydrogenase subunit B; Validated; Region: PRK06411 298653015621 NADH-quinone oxidoreductase, B subunit; Region: nuoB_fam; TIGR01957 298653015622 NADH dehydrogenase subunit A; Validated; Region: PRK07928 298653015623 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 298653015624 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653015625 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 298653015626 ubiquinone/menaquinone biosynthesis methyltransferase; Reviewed; Region: ubiE; PRK00216 298653015627 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 298653015628 adenosine deaminase; Provisional; Region: PRK09358 298653015629 active site 298653015630 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 298653015631 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653015632 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653015633 active site 298653015634 ATP binding site [chemical binding]; other site 298653015635 substrate binding site [chemical binding]; other site 298653015636 activation loop (A-loop); other site 298653015637 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 298653015638 putative active site [active] 298653015639 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 298653015640 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 298653015641 active site 298653015642 SAM binding site [chemical binding]; other site 298653015643 homodimer interface [polypeptide binding]; other site 298653015644 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 298653015645 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 298653015646 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 298653015647 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 298653015648 Active Sites [active] 298653015649 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 298653015650 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 298653015651 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 298653015652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653015653 Response regulator receiver domain; Region: Response_reg; pfam00072 298653015654 active site 298653015655 phosphorylation site [posttranslational modification] 298653015656 intermolecular recognition site; other site 298653015657 dimerization interface [polypeptide binding]; other site 298653015658 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653015659 non-specific DNA binding site [nucleotide binding]; other site 298653015660 salt bridge; other site 298653015661 sequence-specific DNA binding site [nucleotide binding]; other site 298653015662 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 298653015663 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 298653015664 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 298653015665 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 298653015666 FeS/SAM binding site; other site 298653015667 Flavoprotein; Region: Flavoprotein; pfam02441 298653015668 aromatic acid decarboxylase; Validated; Region: PRK05920 298653015669 prenyltransferase; Reviewed; Region: ubiA; PRK12888 298653015670 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 298653015671 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 298653015672 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 298653015673 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 298653015674 ResB-like family; Region: ResB; pfam05140 298653015675 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 298653015676 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 298653015677 catalytic residues [active] 298653015678 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 298653015679 Methyltransferase domain; Region: Methyltransf_26; pfam13659 298653015680 S-adenosylmethionine binding site [chemical binding]; other site 298653015681 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 298653015682 catalytic core [active] 298653015683 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 298653015684 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 298653015685 inhibitor-cofactor binding pocket; inhibition site 298653015686 pyridoxal 5'-phosphate binding site [chemical binding]; other site 298653015687 catalytic residue [active] 298653015688 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 298653015689 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653015690 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 298653015691 Walker A/P-loop; other site 298653015692 ATP binding site [chemical binding]; other site 298653015693 Q-loop/lid; other site 298653015694 ABC transporter signature motif; other site 298653015695 Walker B; other site 298653015696 D-loop; other site 298653015697 H-loop/switch region; other site 298653015698 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 298653015699 ABC-2 type transporter; Region: ABC2_membrane; cl11417 298653015700 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 298653015701 metal-binding site [ion binding] 298653015702 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 298653015703 dimer interface [polypeptide binding]; other site 298653015704 active site 298653015705 Schiff base residues; other site 298653015706 homodimer interface [polypeptide binding]; other site 298653015707 active site 298653015708 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 298653015709 SAM binding site [chemical binding]; other site 298653015710 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 298653015711 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 298653015712 active site 298653015713 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 298653015714 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 298653015715 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 298653015716 active site 298653015717 domain interfaces; other site 298653015718 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 298653015719 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 298653015720 tRNA; other site 298653015721 putative tRNA binding site [nucleotide binding]; other site 298653015722 putative NADP binding site [chemical binding]; other site 298653015723 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 298653015724 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 298653015725 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 298653015726 CoA binding domain; Region: CoA_binding; pfam02629 298653015727 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 298653015728 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 298653015729 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 298653015730 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 298653015731 DNA binding residues [nucleotide binding] 298653015732 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 298653015733 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 298653015734 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 298653015735 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 298653015736 putative acyl-acceptor binding pocket; other site 298653015737 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 298653015738 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 298653015739 putative NAD(P) binding site [chemical binding]; other site 298653015740 active site 298653015741 putative substrate binding site [chemical binding]; other site 298653015742 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 298653015743 Uncharacterized conserved protein [Function unknown]; Region: COG1912 298653015744 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 298653015745 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653015746 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 298653015747 Acyltransferase family; Region: Acyl_transf_3; pfam01757 298653015748 Methyltransferase domain; Region: Methyltransf_11; pfam08241 298653015749 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 298653015750 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 298653015751 exopolyphosphatase; Region: exo_poly_only; TIGR03706 298653015752 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 298653015753 nucleotide binding site [chemical binding]; other site 298653015754 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 298653015755 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653015756 active site 298653015757 phosphorylation site [posttranslational modification] 298653015758 intermolecular recognition site; other site 298653015759 dimerization interface [polypeptide binding]; other site 298653015760 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 298653015761 DNA binding site [nucleotide binding] 298653015762 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 298653015763 dimer interface [polypeptide binding]; other site 298653015764 phosphorylation site [posttranslational modification] 298653015765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653015766 ATP binding site [chemical binding]; other site 298653015767 Mg2+ binding site [ion binding]; other site 298653015768 G-X-G motif; other site 298653015769 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 298653015770 PhoU domain; Region: PhoU; pfam01895 298653015771 PhoU domain; Region: PhoU; pfam01895 298653015772 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 298653015773 catalytic core [active] 298653015774 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 298653015775 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 298653015776 metal binding site 2 [ion binding]; metal-binding site 298653015777 putative DNA binding helix; other site 298653015778 metal binding site 1 [ion binding]; metal-binding site 298653015779 dimer interface [polypeptide binding]; other site 298653015780 structural Zn2+ binding site [ion binding]; other site 298653015781 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 298653015782 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 298653015783 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 298653015784 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 298653015785 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 298653015786 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653015787 Walker A/P-loop; other site 298653015788 ATP binding site [chemical binding]; other site 298653015789 Q-loop/lid; other site 298653015790 ABC transporter signature motif; other site 298653015791 Walker B; other site 298653015792 D-loop; other site 298653015793 H-loop/switch region; other site 298653015794 TOBE domain; Region: TOBE_2; cl01440 298653015795 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 298653015796 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 298653015797 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 298653015798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653015799 dimer interface [polypeptide binding]; other site 298653015800 conserved gate region; other site 298653015801 ABC-ATPase subunit interface; other site 298653015802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653015803 dimer interface [polypeptide binding]; other site 298653015804 conserved gate region; other site 298653015805 ABC-ATPase subunit interface; other site 298653015806 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 298653015807 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 298653015808 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 298653015809 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 298653015810 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653015811 non-specific DNA binding site [nucleotide binding]; other site 298653015812 salt bridge; other site 298653015813 sequence-specific DNA binding site [nucleotide binding]; other site 298653015814 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 298653015815 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 298653015816 active site 298653015817 catalytic tetrad [active] 298653015818 RNase III inhibitor; Provisional; Region: PRK00431 298653015819 ADP-ribose binding site [chemical binding]; other site 298653015820 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 298653015821 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 298653015822 putative ADP-binding pocket [chemical binding]; other site 298653015823 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 298653015824 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 298653015825 heme-binding site [chemical binding]; other site 298653015826 DsrE/DsrF-like family; Region: DrsE; cl00672 298653015827 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 298653015828 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 298653015829 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 298653015830 active site residue [active] 298653015831 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 298653015832 active site residue [active] 298653015833 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 298653015834 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 298653015835 catalytic residues [active] 298653015836 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 298653015837 Ubiquitin-like proteins; Region: UBQ; cl00155 298653015838 charged pocket; other site 298653015839 hydrophobic patch; other site 298653015840 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 298653015841 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 298653015842 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 298653015843 DNA binding site [nucleotide binding] 298653015844 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 298653015845 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 298653015846 Coenzyme A binding pocket [chemical binding]; other site 298653015847 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 298653015848 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 298653015849 anti sigma factor interaction site; other site 298653015850 regulatory phosphorylation site [posttranslational modification]; other site 298653015851 Frankia-40 domain; Region: Frankia_40_dom; TIGR03917 298653015852 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 298653015853 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 298653015854 Predicted membrane protein [Function unknown]; Region: COG2119 298653015855 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 298653015856 selenocysteine synthase; Provisional; Region: PRK04311 298653015857 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 298653015858 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 298653015859 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653015860 Walker A/P-loop; other site 298653015861 ATP binding site [chemical binding]; other site 298653015862 Q-loop/lid; other site 298653015863 ABC transporter signature motif; other site 298653015864 Walker B; other site 298653015865 D-loop; other site 298653015866 H-loop/switch region; other site 298653015867 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 298653015868 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 298653015869 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 298653015870 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 298653015871 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653015872 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 298653015873 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 298653015874 catalytic triad [active] 298653015875 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 298653015876 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 298653015877 FeS/SAM binding site; other site 298653015878 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 298653015879 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653015880 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 298653015881 non-specific DNA binding site [nucleotide binding]; other site 298653015882 salt bridge; other site 298653015883 sequence-specific DNA binding site [nucleotide binding]; other site 298653015884 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 298653015885 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653015886 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 298653015887 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 298653015888 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 298653015889 XdhC Rossmann domain; Region: XdhC_C; pfam13478 298653015890 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 298653015891 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 298653015892 metal ion-dependent adhesion site (MIDAS); other site 298653015893 MoxR-like ATPases [General function prediction only]; Region: COG0714 298653015894 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 298653015895 Walker A motif; other site 298653015896 ATP binding site [chemical binding]; other site 298653015897 Walker B motif; other site 298653015898 arginine finger; other site 298653015899 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 298653015900 active site 298653015901 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 298653015902 PII uridylyl-transferase; Provisional; Region: PRK03381 298653015903 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 298653015904 metal binding triad; other site 298653015905 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 298653015906 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 298653015907 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 298653015908 Nitrogen regulatory protein P-II; Region: P-II; smart00938 298653015909 ammonium transporter; Region: amt; TIGR00836 298653015910 NlpC/P60 family; Region: NLPC_P60; pfam00877 298653015911 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 298653015912 Helix-turn-helix domains; Region: HTH; cl00088 298653015913 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 298653015914 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 298653015915 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 298653015916 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653015917 Major Facilitator Superfamily; Region: MFS_1; pfam07690 298653015918 putative substrate translocation pore; other site 298653015919 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653015920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653015921 S-adenosylmethionine binding site [chemical binding]; other site 298653015922 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 298653015923 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 298653015924 active site 298653015925 catalytic tetrad [active] 298653015926 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653015927 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653015928 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 298653015929 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 298653015930 active site 298653015931 metal binding site [ion binding]; metal-binding site 298653015932 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 298653015933 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 298653015934 NAD(P) binding site [chemical binding]; other site 298653015935 tetracycline repressor protein TetR; Provisional; Region: PRK13756 298653015936 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653015937 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 298653015938 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 298653015939 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 298653015940 DNA binding residues [nucleotide binding] 298653015941 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 298653015942 DNA binding site [nucleotide binding] 298653015943 Int/Topo IB signature motif; other site 298653015944 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 298653015945 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 298653015946 conserved cys residue [active] 298653015947 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 298653015948 PAS domain; Region: PAS; smart00091 298653015949 PAS fold; Region: PAS_4; pfam08448 298653015950 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 298653015951 GAF domain; Region: GAF; cl15785 298653015952 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 298653015953 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 298653015954 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 298653015955 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 298653015956 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 298653015957 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 298653015958 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 298653015959 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 298653015960 ABC-2 type transporter; Region: ABC2_membrane; cl11417 298653015961 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653015962 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 298653015963 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 298653015964 Sulfate transporter family; Region: Sulfate_transp; cl15842 298653015965 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 298653015966 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 298653015967 dimerization interface [polypeptide binding]; other site 298653015968 putative DNA binding site [nucleotide binding]; other site 298653015969 putative Zn2+ binding site [ion binding]; other site 298653015970 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653015971 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 298653015972 putative ligand binding site [chemical binding]; other site 298653015973 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653015974 S-adenosylmethionine binding site [chemical binding]; other site 298653015975 Transcriptional regulator [Transcription]; Region: IclR; COG1414 298653015976 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 298653015977 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653015978 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653015979 NAD(P) binding site [chemical binding]; other site 298653015980 active site 298653015981 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653015982 classical (c) SDRs; Region: SDR_c; cd05233 298653015983 NAD(P) binding site [chemical binding]; other site 298653015984 active site 298653015985 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 298653015986 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653015987 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844 298653015988 active site 298653015989 catalytic triad [active] 298653015990 oxyanion hole [active] 298653015991 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 298653015992 Cupin domain; Region: Cupin_2; pfam07883 298653015993 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 298653015994 classical (c) SDRs; Region: SDR_c; cd05233 298653015995 NAD(P) binding site [chemical binding]; other site 298653015996 active site 298653015997 Epoxide hydrolase N terminus; Region: EHN; pfam06441 298653015998 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 298653015999 Peptidase family M48; Region: Peptidase_M48; cl12018 298653016000 Protein of unknown function (DUF419); Region: DUF419; cl15265 298653016001 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 298653016002 Predicted ATPase [General function prediction only]; Region: COG3903 298653016003 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653016004 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 298653016005 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 298653016006 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653016007 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 298653016008 Walker A/P-loop; other site 298653016009 ATP binding site [chemical binding]; other site 298653016010 Q-loop/lid; other site 298653016011 ABC transporter signature motif; other site 298653016012 Walker B; other site 298653016013 D-loop; other site 298653016014 H-loop/switch region; other site 298653016015 Protein of unknown function DUF72; Region: DUF72; pfam01904 298653016016 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 298653016017 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 298653016018 AAA domain; Region: AAA_14; pfam13173 298653016019 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 298653016020 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 298653016021 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 298653016022 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 298653016023 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 298653016024 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653016025 substrate binding site [chemical binding]; other site 298653016026 oxyanion hole (OAH) forming residues; other site 298653016027 trimer interface [polypeptide binding]; other site 298653016028 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 298653016029 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653016030 metal binding site [ion binding]; metal-binding site 298653016031 active site 298653016032 I-site; other site 298653016033 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 298653016034 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 298653016035 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 298653016036 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 298653016037 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 298653016038 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 298653016039 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 298653016040 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 298653016041 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 298653016042 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 298653016043 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 298653016044 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 298653016045 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653016046 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 298653016047 active site 298653016048 metal binding site [ion binding]; metal-binding site 298653016049 interdomain interaction site; other site 298653016050 hypothetical protein; Provisional; Region: PRK14709 298653016051 D5 N terminal like; Region: D5_N; pfam08706 298653016052 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 298653016053 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 298653016054 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 298653016055 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 298653016056 active site 298653016057 DNA binding site [nucleotide binding] 298653016058 Int/Topo IB signature motif; other site 298653016059 PIN domain; Region: PIN_4; pfam13638 298653016060 putative active site [active] 298653016061 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 298653016062 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653016063 non-specific DNA binding site [nucleotide binding]; other site 298653016064 salt bridge; other site 298653016065 sequence-specific DNA binding site [nucleotide binding]; other site 298653016066 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 298653016067 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 298653016068 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 298653016069 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 298653016070 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 298653016071 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 298653016072 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 298653016073 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 298653016074 Helix-turn-helix domain; Region: HTH_31; pfam13560 298653016075 Cupin domain; Region: Cupin_2; cl09118 298653016076 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 298653016077 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 298653016078 NAD binding site [chemical binding]; other site 298653016079 substrate binding site [chemical binding]; other site 298653016080 homodimer interface [polypeptide binding]; other site 298653016081 active site 298653016082 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 298653016083 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653016084 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 298653016085 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 298653016086 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 298653016087 inhibitor-cofactor binding pocket; inhibition site 298653016088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 298653016089 catalytic residue [active] 298653016090 Low molecular weight phosphatase family; Region: LMWPc; cd00115 298653016091 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 298653016092 active site 298653016093 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 298653016094 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 298653016095 active site 298653016096 homodimer interface [polypeptide binding]; other site 298653016097 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 298653016098 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 298653016099 Recombinase; Region: Recombinase; pfam07508 298653016100 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 298653016101 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653016102 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 298653016103 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 298653016104 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 298653016105 RNA binding surface [nucleotide binding]; other site 298653016106 Bacterial transcriptional activator domain; Region: BTAD; smart01043 298653016107 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 298653016108 active site 298653016109 metal binding site [ion binding]; metal-binding site 298653016110 homotetramer interface [polypeptide binding]; other site 298653016111 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 298653016112 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 298653016113 Int/Topo IB signature motif; other site 298653016114 Frankia-40 domain; Region: Frankia_40_dom; TIGR03917 298653016115 Helix-turn-helix domain; Region: HTH_17; pfam12728 298653016116 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 298653016117 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653016118 PspC domain; Region: PspC; cl00864 298653016119 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653016120 non-specific DNA binding site [nucleotide binding]; other site 298653016121 salt bridge; other site 298653016122 sequence-specific DNA binding site [nucleotide binding]; other site 298653016123 Frankia-40 domain; Region: Frankia_40_dom; TIGR03917 298653016124 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 298653016125 non-specific DNA binding site [nucleotide binding]; other site 298653016126 salt bridge; other site 298653016127 sequence-specific DNA binding site [nucleotide binding]; other site 298653016128 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 298653016129 HEPN domain; Region: HEPN; cl00824 298653016130 Plant protein of unknown function (DUF946); Region: DUF946; pfam06101 298653016131 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 298653016132 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 298653016133 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 298653016134 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 298653016135 Protein of unknown function (DUF433); Region: DUF433; pfam04255 298653016136 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 298653016137 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 298653016138 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 298653016139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 298653016140 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 298653016141 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 298653016142 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 298653016143 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 298653016144 active site 298653016145 catalytic tetrad [active] 298653016146 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 298653016147 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 298653016148 pyridoxal 5'-phosphate binding site [chemical binding]; other site 298653016149 homodimer interface [polypeptide binding]; other site 298653016150 catalytic residue [active] 298653016151 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653016152 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 298653016153 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 298653016154 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 298653016155 protein binding site [polypeptide binding]; other site 298653016156 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653016157 NB-ARC domain; Region: NB-ARC; pfam00931 298653016158 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 298653016159 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 298653016160 TPR motif; other site 298653016161 binding surface 298653016162 Tetratricopeptide repeat; Region: TPR_10; pfam13374 298653016163 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 298653016164 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 298653016165 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 298653016166 Helix-turn-helix domains; Region: HTH; cl00088 298653016167 hypothetical protein; Provisional; Region: PRK06126 298653016168 DDE superfamily endonuclease; Region: DDE_3; pfam13358 298653016169 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 298653016170 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 298653016171 Homeodomain-like domain; Region: HTH_32; pfam13565 298653016172 Winged helix-turn helix; Region: HTH_33; pfam13592 298653016173 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 298653016174 DDE superfamily endonuclease; Region: DDE_5; cl02413 298653016175 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653016176 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653016177 Cupin domain; Region: Cupin_2; cl09118 298653016178 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653016179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653016180 active site 298653016181 phosphorylation site [posttranslational modification] 298653016182 intermolecular recognition site; other site 298653016183 dimerization interface [polypeptide binding]; other site 298653016184 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653016185 DNA binding residues [nucleotide binding] 298653016186 dimerization interface [polypeptide binding]; other site 298653016187 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 298653016188 Histidine kinase; Region: HisKA_3; pfam07730 298653016189 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 298653016190 ATP binding site [chemical binding]; other site 298653016191 Mg2+ binding site [ion binding]; other site 298653016192 G-X-G motif; other site 298653016193 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 298653016194 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653016195 Walker A/P-loop; other site 298653016196 ATP binding site [chemical binding]; other site 298653016197 Q-loop/lid; other site 298653016198 ABC transporter signature motif; other site 298653016199 Walker B; other site 298653016200 D-loop; other site 298653016201 H-loop/switch region; other site 298653016202 TIR domain; Region: TIR_2; pfam13676 298653016203 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653016204 Walker A motif; other site 298653016205 ATP binding site [chemical binding]; other site 298653016206 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 298653016207 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 298653016208 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653016209 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653016210 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 298653016211 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 298653016212 trimer interface [polypeptide binding]; other site 298653016213 putative metal binding site [ion binding]; other site 298653016214 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653016215 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653016216 Primosomal replication protein priB and priC; Region: priB_priC; cl11483 298653016217 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 298653016218 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 298653016219 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 298653016220 DNA binding residues [nucleotide binding] 298653016221 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 298653016222 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 298653016223 NAD(P) binding site [chemical binding]; other site 298653016224 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 298653016225 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653016226 NAD(P) binding site [chemical binding]; other site 298653016227 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 298653016228 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 298653016229 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 298653016230 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653016231 NAD(P) binding site [chemical binding]; other site 298653016232 active site 298653016233 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 298653016234 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 298653016235 active site 298653016236 catalytic residues [active] 298653016237 DNA binding site [nucleotide binding] 298653016238 Int/Topo IB signature motif; other site 298653016239 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 298653016240 5,10-methylenetetrahydrofolate reductase [Amino acid transport and metabolism]; Region: MetF; COG0685 298653016241 FAD binding site [chemical binding]; other site 298653016242 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 298653016243 DNA-binding interface [nucleotide binding]; DNA binding site 298653016244 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 298653016245 multiple promoter invertase; Provisional; Region: mpi; PRK13413 298653016246 catalytic residues [active] 298653016247 catalytic nucleophile [active] 298653016248 Presynaptic Site I dimer interface [polypeptide binding]; other site 298653016249 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 298653016250 Synaptic Flat tetramer interface [polypeptide binding]; other site 298653016251 Synaptic Site I dimer interface [polypeptide binding]; other site 298653016252 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 298653016253 Protein of unknown function (DUF664); Region: DUF664; pfam04978 298653016254 DinB superfamily; Region: DinB_2; pfam12867 298653016255 Zeta toxin; Region: Zeta_toxin; pfam06414 298653016256 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653016257 active site 298653016258 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 298653016259 P-loop; other site 298653016260 Magnesium ion binding site [ion binding]; other site 298653016261 TIR domain; Region: TIR_2; pfam13676 298653016262 TIR domain; Region: TIR_2; pfam13676 298653016263 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 298653016264 metal ion-dependent adhesion site (MIDAS); other site 298653016265 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 298653016266 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653016267 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 298653016268 active site 298653016269 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 298653016270 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 298653016271 putative metal binding site [ion binding]; other site 298653016272 Tellurium resistance protein; Region: Tellurium_res; pfam10138 298653016273 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 298653016274 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 298653016275 putative metal binding site [ion binding]; other site 298653016276 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 298653016277 TIR domain; Region: TIR_2; pfam13676 298653016278 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653016279 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 298653016280 hypothetical protein; Provisional; Region: PRK06194 298653016281 classical (c) SDRs; Region: SDR_c; cd05233 298653016282 NAD(P) binding site [chemical binding]; other site 298653016283 active site 298653016284 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 298653016285 active site 298653016286 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 298653016287 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 298653016288 CysD dimerization site [polypeptide binding]; other site 298653016289 G1 box; other site 298653016290 putative GEF interaction site [polypeptide binding]; other site 298653016291 GTP/Mg2+ binding site [chemical binding]; other site 298653016292 Switch I region; other site 298653016293 G2 box; other site 298653016294 G3 box; other site 298653016295 Switch II region; other site 298653016296 G4 box; other site 298653016297 G5 box; other site 298653016298 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 298653016299 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 298653016300 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 298653016301 ligand-binding site [chemical binding]; other site 298653016302 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 298653016303 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 298653016304 Active Sites [active] 298653016305 FMN binding site [chemical binding]; other site 298653016306 Nitroreductase family; Region: Nitroreductase; pfam00881 298653016307 dimer interface [polypeptide binding]; other site 298653016308 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653016309 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 298653016310 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653016311 NAD(P) binding site [chemical binding]; other site 298653016312 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653016313 active site 298653016314 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653016315 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653016316 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 298653016317 putative metal binding site [ion binding]; other site 298653016318 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 298653016319 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 298653016320 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 298653016321 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 298653016322 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 298653016323 Protein of unknown function (DUF419); Region: DUF419; cl15265 298653016324 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 298653016325 RNA binding surface [nucleotide binding]; other site 298653016326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653016327 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 298653016328 dimer interface [polypeptide binding]; other site 298653016329 putative anticodon binding site; other site 298653016330 tRNA synthetases class II (D, K and N); Region: tRNA-synt_2; pfam00152 298653016331 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 298653016332 motif 1; other site 298653016333 dimer interface [polypeptide binding]; other site 298653016334 active site 298653016335 motif 2; other site 298653016336 motif 3; other site 298653016337 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 298653016338 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 298653016339 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 298653016340 Walker A/P-loop; other site 298653016341 ATP binding site [chemical binding]; other site 298653016342 Q-loop/lid; other site 298653016343 ABC transporter signature motif; other site 298653016344 Walker B; other site 298653016345 D-loop; other site 298653016346 H-loop/switch region; other site 298653016347 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 298653016348 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 298653016349 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653016350 Walker A/P-loop; other site 298653016351 ATP binding site [chemical binding]; other site 298653016352 Q-loop/lid; other site 298653016353 ABC transporter signature motif; other site 298653016354 Walker B; other site 298653016355 D-loop; other site 298653016356 H-loop/switch region; other site 298653016357 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 298653016358 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653016359 NAD(P) binding site [chemical binding]; other site 298653016360 active site 298653016361 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653016362 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653016363 active site 298653016364 Beta-lactamase; Region: Beta-lactamase; pfam00144 298653016365 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 298653016366 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 298653016367 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 298653016368 DNA binding site [nucleotide binding] 298653016369 active site 298653016370 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 298653016371 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 298653016372 AlkA N-terminal domain; Region: AlkA_N; pfam06029 298653016373 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 298653016374 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 298653016375 minor groove reading motif; other site 298653016376 helix-hairpin-helix signature motif; other site 298653016377 substrate binding pocket [chemical binding]; other site 298653016378 active site 298653016379 PAS domain S-box; Region: sensory_box; TIGR00229 298653016380 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 298653016381 putative active site [active] 298653016382 heme pocket [chemical binding]; other site 298653016383 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653016384 metal binding site [ion binding]; metal-binding site 298653016385 active site 298653016386 I-site; other site 298653016387 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 298653016388 hypothetical protein; Provisional; Region: PRK11770 298653016389 Domain of unknown function (DUF307); Region: DUF307; pfam03733 298653016390 Domain of unknown function (DUF307); Region: DUF307; pfam03733 298653016391 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 298653016392 nucleotide binding site [chemical binding]; other site 298653016393 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 298653016394 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 298653016395 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 298653016396 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 298653016397 dimer interface [polypeptide binding]; other site 298653016398 pyridoxal 5'-phosphate binding site [chemical binding]; other site 298653016399 catalytic residue [active] 298653016400 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 298653016401 cystathionine gamma-synthase; Provisional; Region: PRK07811 298653016402 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 298653016403 homodimer interface [polypeptide binding]; other site 298653016404 substrate-cofactor binding pocket; other site 298653016405 pyridoxal 5'-phosphate binding site [chemical binding]; other site 298653016406 catalytic residue [active] 298653016407 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653016408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653016409 active site 298653016410 phosphorylation site [posttranslational modification] 298653016411 intermolecular recognition site; other site 298653016412 dimerization interface [polypeptide binding]; other site 298653016413 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653016414 dimerization interface [polypeptide binding]; other site 298653016415 DNA binding residues [nucleotide binding] 298653016416 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 298653016417 Histidine kinase; Region: HisKA_3; pfam07730 298653016418 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 298653016419 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 298653016420 trimer interface [polypeptide binding]; other site 298653016421 active site 298653016422 substrate binding site [chemical binding]; other site 298653016423 CoA binding site [chemical binding]; other site 298653016424 Phosphopantetheine attachment site; Region: PP-binding; cl09936 298653016425 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 298653016426 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 298653016427 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 298653016428 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 298653016429 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653016430 active site 298653016431 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 298653016432 PAS domain; Region: PAS_9; pfam13426 298653016433 putative active site [active] 298653016434 heme pocket [chemical binding]; other site 298653016435 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653016436 metal binding site [ion binding]; metal-binding site 298653016437 active site 298653016438 I-site; other site 298653016439 PAS domain S-box; Region: sensory_box; TIGR00229 298653016440 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 298653016441 putative active site [active] 298653016442 heme pocket [chemical binding]; other site 298653016443 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653016444 metal binding site [ion binding]; metal-binding site 298653016445 active site 298653016446 I-site; other site 298653016447 PAS domain S-box; Region: sensory_box; TIGR00229 298653016448 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 298653016449 putative active site [active] 298653016450 heme pocket [chemical binding]; other site 298653016451 PAS domain S-box; Region: sensory_box; TIGR00229 298653016452 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 298653016453 putative active site [active] 298653016454 heme pocket [chemical binding]; other site 298653016455 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 298653016456 dimer interface [polypeptide binding]; other site 298653016457 phosphorylation site [posttranslational modification] 298653016458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653016459 ATP binding site [chemical binding]; other site 298653016460 Mg2+ binding site [ion binding]; other site 298653016461 G-X-G motif; other site 298653016462 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 298653016463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653016464 active site 298653016465 phosphorylation site [posttranslational modification] 298653016466 intermolecular recognition site; other site 298653016467 dimerization interface [polypeptide binding]; other site 298653016468 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 298653016469 active site 298653016470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653016471 Response regulator receiver domain; Region: Response_reg; pfam00072 298653016472 active site 298653016473 phosphorylation site [posttranslational modification] 298653016474 intermolecular recognition site; other site 298653016475 dimerization interface [polypeptide binding]; other site 298653016476 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 298653016477 cyclase homology domain; Region: CHD; cd07302 298653016478 nucleotidyl binding site; other site 298653016479 metal binding site [ion binding]; metal-binding site 298653016480 dimer interface [polypeptide binding]; other site 298653016481 classical (c) SDRs; Region: SDR_c; cd05233 298653016482 NAD(P) binding site [chemical binding]; other site 298653016483 active site 298653016484 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 298653016485 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653016486 NAD(P) binding site [chemical binding]; other site 298653016487 active site 298653016488 probable F420-dependent oxidoreductase, MSMEG_3544 family; Region: F420_MSMEG_3544; TIGR03854 298653016489 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653016490 NMT1-like family; Region: NMT1_2; cl15260 298653016491 Protein kinase domain; Region: Pkinase; pfam00069 298653016492 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653016493 active site 298653016494 ATP binding site [chemical binding]; other site 298653016495 substrate binding site [chemical binding]; other site 298653016496 activation loop (A-loop); other site 298653016497 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 298653016498 Helix-turn-helix domain; Region: HTH_18; pfam12833 298653016499 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 298653016500 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 298653016501 Fic family protein [Function unknown]; Region: COG3177 298653016502 Fic/DOC family; Region: Fic; pfam02661 298653016503 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653016504 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653016505 active site 298653016506 ATP binding site [chemical binding]; other site 298653016507 substrate binding site [chemical binding]; other site 298653016508 activation loop (A-loop); other site 298653016509 Methyltransferase domain; Region: Methyltransf_31; pfam13847 298653016510 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653016511 S-adenosylmethionine binding site [chemical binding]; other site 298653016512 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 298653016513 HSP70 interaction site [polypeptide binding]; other site 298653016514 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 298653016515 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 298653016516 ligand binding site [chemical binding]; other site 298653016517 Uncharacterized conserved protein (DUF2203); Region: DUF2203; pfam09969 298653016518 hypothetical protein; Provisional; Region: PRK08317 298653016519 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653016520 S-adenosylmethionine binding site [chemical binding]; other site 298653016521 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 298653016522 putative acyl-acceptor binding pocket; other site 298653016523 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 298653016524 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 298653016525 nucleophile elbow; other site 298653016526 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 298653016527 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 298653016528 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653016529 Domain of unknown function (DUF4009); Region: DUF4009; pfam13193 298653016530 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653016531 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 298653016532 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 298653016533 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653016534 NAD(P) binding site [chemical binding]; other site 298653016535 active site 298653016536 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653016537 DEAD-like helicases superfamily; Region: DEXDc; smart00487 298653016538 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 298653016539 ATP binding site [chemical binding]; other site 298653016540 ATP binding site [chemical binding]; other site 298653016541 putative Mg++ binding site [ion binding]; other site 298653016542 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 298653016543 nucleotide binding region [chemical binding]; other site 298653016544 ATP-binding site [chemical binding]; other site 298653016545 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 298653016546 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653016547 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 298653016548 classical (c) SDRs; Region: SDR_c; cd05233 298653016549 NAD(P) binding site [chemical binding]; other site 298653016550 active site 298653016551 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 298653016552 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653016553 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 298653016554 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 298653016555 dimerization interface [polypeptide binding]; other site 298653016556 ligand binding site [chemical binding]; other site 298653016557 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653016558 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653016559 L-asparaginase II; Region: Asparaginase_II; pfam06089 298653016560 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 298653016561 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 298653016562 dimer interface [polypeptide binding]; other site 298653016563 active site 298653016564 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 298653016565 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 298653016566 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 298653016567 active site 298653016568 metal binding site [ion binding]; metal-binding site 298653016569 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 298653016570 MarR family; Region: MarR; pfam01047 298653016571 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; pfam09587 298653016572 active site 298653016573 metal binding site [ion binding]; metal-binding site 298653016574 Predicted membrane protein [Function unknown]; Region: COG2259 298653016575 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 298653016576 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 298653016577 nucleotide binding site [chemical binding]; other site 298653016578 putative NEF/HSP70 interaction site [polypeptide binding]; other site 298653016579 SBD interface [polypeptide binding]; other site 298653016580 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 298653016581 E3 interaction surface; other site 298653016582 lipoyl attachment site [posttranslational modification]; other site 298653016583 FOG: WD40 repeat [General function prediction only]; Region: COG2319 298653016584 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 298653016585 structural tetrad; other site 298653016586 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 298653016587 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 298653016588 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 298653016589 Walker A/P-loop; other site 298653016590 ATP binding site [chemical binding]; other site 298653016591 Q-loop/lid; other site 298653016592 ABC transporter signature motif; other site 298653016593 Walker B; other site 298653016594 D-loop; other site 298653016595 H-loop/switch region; other site 298653016596 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 298653016597 GAF domain; Region: GAF; cl15785 298653016598 Histidine kinase; Region: HisKA_3; pfam07730 298653016599 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653016600 Mg2+ binding site [ion binding]; other site 298653016601 G-X-G motif; other site 298653016602 FtsX-like permease family; Region: FtsX; pfam02687 298653016603 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653016604 active site 298653016605 phosphorylation site [posttranslational modification] 298653016606 intermolecular recognition site; other site 298653016607 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653016608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653016609 active site 298653016610 phosphorylation site [posttranslational modification] 298653016611 intermolecular recognition site; other site 298653016612 dimerization interface [polypeptide binding]; other site 298653016613 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653016614 DNA binding residues [nucleotide binding] 298653016615 dimerization interface [polypeptide binding]; other site 298653016616 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 298653016617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653016618 active site 298653016619 phosphorylation site [posttranslational modification] 298653016620 intermolecular recognition site; other site 298653016621 dimerization interface [polypeptide binding]; other site 298653016622 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 298653016623 DNA binding site [nucleotide binding] 298653016624 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 298653016625 dimerization interface [polypeptide binding]; other site 298653016626 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 298653016627 dimer interface [polypeptide binding]; other site 298653016628 phosphorylation site [posttranslational modification] 298653016629 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653016630 ATP binding site [chemical binding]; other site 298653016631 Mg2+ binding site [ion binding]; other site 298653016632 G-X-G motif; other site 298653016633 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 298653016634 putative active site [active] 298653016635 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 298653016636 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 298653016637 active site 298653016638 GtrA-like protein; Region: GtrA; cl00971 298653016639 pyruvate carboxylase; Reviewed; Region: PRK12999 298653016640 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 298653016641 ATP-grasp domain; Region: ATP-grasp_4; cl03087 298653016642 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 298653016643 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 298653016644 active site 298653016645 catalytic residues [active] 298653016646 metal binding site [ion binding]; metal-binding site 298653016647 homodimer binding site [polypeptide binding]; other site 298653016648 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 298653016649 carboxyltransferase (CT) interaction site; other site 298653016650 biotinylation site [posttranslational modification]; other site 298653016651 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 298653016652 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 298653016653 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 298653016654 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 298653016655 TMP-binding site; other site 298653016656 ATP-binding site [chemical binding]; other site 298653016657 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 298653016658 homodimer interface [polypeptide binding]; other site 298653016659 putative substrate binding pocket [chemical binding]; other site 298653016660 diiron center [ion binding]; other site 298653016661 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 298653016662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653016663 active site 298653016664 phosphorylation site [posttranslational modification] 298653016665 intermolecular recognition site; other site 298653016666 dimerization interface [polypeptide binding]; other site 298653016667 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 298653016668 DNA binding site [nucleotide binding] 298653016669 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 298653016670 dimerization interface [polypeptide binding]; other site 298653016671 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 298653016672 dimer interface [polypeptide binding]; other site 298653016673 phosphorylation site [posttranslational modification] 298653016674 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653016675 ATP binding site [chemical binding]; other site 298653016676 Mg2+ binding site [ion binding]; other site 298653016677 G-X-G motif; other site 298653016678 Histidine kinase; Region: HisKA_3; pfam07730 298653016679 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653016680 ATP binding site [chemical binding]; other site 298653016681 Mg2+ binding site [ion binding]; other site 298653016682 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653016683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653016684 active site 298653016685 phosphorylation site [posttranslational modification] 298653016686 intermolecular recognition site; other site 298653016687 dimerization interface [polypeptide binding]; other site 298653016688 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653016689 DNA binding residues [nucleotide binding] 298653016690 dimerization interface [polypeptide binding]; other site 298653016691 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 298653016692 nudix motif; other site 298653016693 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 298653016694 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 298653016695 Walker A/P-loop; other site 298653016696 ATP binding site [chemical binding]; other site 298653016697 Q-loop/lid; other site 298653016698 ABC transporter signature motif; other site 298653016699 Walker B; other site 298653016700 D-loop; other site 298653016701 H-loop/switch region; other site 298653016702 Oxidoreductase molybdopterin binding domain; Region: Oxidored_molyb; pfam00174 298653016703 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 298653016704 Moco binding site; other site 298653016705 metal coordination site [ion binding]; other site 298653016706 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 298653016707 Interferon-induced transmembrane protein; Region: CD225; pfam04505 298653016708 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 298653016709 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 298653016710 nudix motif; other site 298653016711 TIGR03085 family protein; Region: TIGR03085 298653016712 Response regulator receiver domain; Region: Response_reg; pfam00072 298653016713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653016714 active site 298653016715 phosphorylation site [posttranslational modification] 298653016716 intermolecular recognition site; other site 298653016717 dimerization interface [polypeptide binding]; other site 298653016718 CHASE3 domain; Region: CHASE3; pfam05227 298653016719 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 298653016720 dimer interface [polypeptide binding]; other site 298653016721 phosphorylation site [posttranslational modification] 298653016722 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653016723 ATP binding site [chemical binding]; other site 298653016724 Mg2+ binding site [ion binding]; other site 298653016725 G-X-G motif; other site 298653016726 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 298653016727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653016728 active site 298653016729 phosphorylation site [posttranslational modification] 298653016730 intermolecular recognition site; other site 298653016731 dimerization interface [polypeptide binding]; other site 298653016732 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 298653016733 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 298653016734 conserved hypothetical protein; Region: TIGR02231 298653016735 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 298653016736 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 298653016737 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 298653016738 NlpC/P60 family; Region: NLPC_P60; pfam00877 298653016739 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 298653016740 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 298653016741 catalytic triad [active] 298653016742 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 298653016743 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 298653016744 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 298653016745 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 298653016746 nucleoside/Zn binding site; other site 298653016747 dimer interface [polypeptide binding]; other site 298653016748 catalytic motif [active] 298653016749 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653016750 NADH(P)-binding; Region: NAD_binding_10; pfam13460 298653016751 NAD(P) binding site [chemical binding]; other site 298653016752 active site 298653016753 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 298653016754 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 298653016755 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 298653016756 catalytic residue [active] 298653016757 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 298653016758 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 298653016759 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653016760 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 298653016761 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 298653016762 metal-binding site [ion binding] 298653016763 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 298653016764 Excalibur calcium-binding domain; Region: Excalibur; smart00894 298653016765 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653016766 classical (c) SDRs; Region: SDR_c; cd05233 298653016767 NAD(P) binding site [chemical binding]; other site 298653016768 active site 298653016769 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 298653016770 Bacterial sugar transferase; Region: Bac_transf; pfam02397 298653016771 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 298653016772 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 298653016773 Probable Catalytic site; other site 298653016774 metal-binding site 298653016775 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 298653016776 trimer interface [polypeptide binding]; other site 298653016777 active site 298653016778 substrate binding site [chemical binding]; other site 298653016779 CoA binding site [chemical binding]; other site 298653016780 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 298653016781 DXD motif; other site 298653016782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653016783 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 298653016784 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 298653016785 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 298653016786 Amidohydrolase; Region: Amidohydro_2; pfam04909 298653016787 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 298653016788 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 298653016789 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 298653016790 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 298653016791 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 298653016792 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 298653016793 colanic acid exporter; Provisional; Region: PRK10459 298653016794 Polysaccharide biosynthesis protein; Region: Polysacc_synt; pfam01943 298653016795 O-Antigen ligase; Region: Wzy_C; cl04850 298653016796 ribonuclease E; Reviewed; Region: rne; PRK10811 298653016797 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 298653016798 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 298653016799 active site 298653016800 Methyltransferase domain; Region: Methyltransf_23; pfam13489 298653016801 Methyltransferase domain; Region: Methyltransf_11; pfam08241 298653016802 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 298653016803 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 298653016804 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 298653016805 Winged helix-turn helix; Region: HTH_33; pfam13592 298653016806 Integrase core domain; Region: rve; cl01316 298653016807 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 298653016808 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 298653016809 substrate binding site; other site 298653016810 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 298653016811 extended (e) SDRs; Region: SDR_e; cd08946 298653016812 NAD(P) binding site [chemical binding]; other site 298653016813 active site 298653016814 substrate binding site [chemical binding]; other site 298653016815 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 298653016816 Methyltransferase domain; Region: Methyltransf_23; pfam13489 298653016817 Methyltransferase domain; Region: Methyltransf_12; pfam08242 298653016818 S-adenosylmethionine binding site [chemical binding]; other site 298653016819 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 298653016820 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 298653016821 Methyltransferase domain; Region: Methyltransf_23; pfam13489 298653016822 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653016823 S-adenosylmethionine binding site [chemical binding]; other site 298653016824 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 298653016825 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 298653016826 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 298653016827 Walker A motif; other site 298653016828 ATP binding site [chemical binding]; other site 298653016829 Walker B motif; other site 298653016830 arginine finger; other site 298653016831 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 298653016832 hypothetical protein; Validated; Region: PRK00153 298653016833 recombination protein RecR; Reviewed; Region: recR; PRK00076 298653016834 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 298653016835 RecR protein; Region: RecR; pfam02132 298653016836 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 298653016837 putative active site [active] 298653016838 putative metal-binding site [ion binding]; other site 298653016839 tetramer interface [polypeptide binding]; other site 298653016840 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 298653016841 DNA binding site [nucleotide binding] 298653016842 Predicted ATPase [General function prediction only]; Region: COG3903 298653016843 Methyltransferase domain; Region: Methyltransf_31; pfam13847 298653016844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653016845 S-adenosylmethionine binding site [chemical binding]; other site 298653016846 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 298653016847 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 298653016848 putative NAD(P) binding site [chemical binding]; other site 298653016849 putative substrate binding site [chemical binding]; other site 298653016850 catalytic Zn binding site [ion binding]; other site 298653016851 structural Zn binding site [ion binding]; other site 298653016852 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 298653016853 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 298653016854 putative metal binding site [ion binding]; other site 298653016855 aspartate kinase; Reviewed; Region: PRK06635 298653016856 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 298653016857 putative nucleotide binding site [chemical binding]; other site 298653016858 putative catalytic residues [active] 298653016859 putative Mg ion binding site [ion binding]; other site 298653016860 putative aspartate binding site [chemical binding]; other site 298653016861 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 298653016862 putative allosteric regulatory site; other site 298653016863 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 298653016864 putative allosteric regulatory residue; other site 298653016865 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 298653016866 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 298653016867 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 298653016868 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 298653016869 DNA-binding site [nucleotide binding]; DNA binding site 298653016870 RNA-binding motif; other site 298653016871 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 298653016872 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 298653016873 active site 298653016874 catalytic tetrad [active] 298653016875 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 298653016876 putative active site; other site 298653016877 putative metal binding residues [ion binding]; other site 298653016878 signature motif; other site 298653016879 putative triphosphate binding site [ion binding]; other site 298653016880 CHAD domain; Region: CHAD; pfam05235 298653016881 CAAX protease self-immunity; Region: Abi; pfam02517 298653016882 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 298653016883 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 298653016884 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 298653016885 Helix-turn-helix domains; Region: HTH; cl00088 298653016886 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 298653016887 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 298653016888 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 298653016889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653016890 Major Facilitator Superfamily; Region: MFS_1; pfam07690 298653016891 putative substrate translocation pore; other site 298653016892 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653016893 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 298653016894 catalytic residue [active] 298653016895 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653016896 classical (c) SDRs; Region: SDR_c; cd05233 298653016897 NAD(P) binding site [chemical binding]; other site 298653016898 active site 298653016899 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 298653016900 dimerization interface [polypeptide binding]; other site 298653016901 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 298653016902 dimer interface [polypeptide binding]; other site 298653016903 phosphorylation site [posttranslational modification] 298653016904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653016905 ATP binding site [chemical binding]; other site 298653016906 Mg2+ binding site [ion binding]; other site 298653016907 G-X-G motif; other site 298653016908 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 298653016909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653016910 active site 298653016911 phosphorylation site [posttranslational modification] 298653016912 intermolecular recognition site; other site 298653016913 dimerization interface [polypeptide binding]; other site 298653016914 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 298653016915 DNA binding site [nucleotide binding] 298653016916 ApbE family; Region: ApbE; pfam02424 298653016917 FMN-binding domain; Region: FMN_bind; cl01081 298653016918 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 298653016919 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 298653016920 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 298653016921 FAD binding pocket [chemical binding]; other site 298653016922 FAD binding motif [chemical binding]; other site 298653016923 phosphate binding motif [ion binding]; other site 298653016924 beta-alpha-beta structure motif; other site 298653016925 NAD binding pocket [chemical binding]; other site 298653016926 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653016927 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653016928 active site 298653016929 ATP binding site [chemical binding]; other site 298653016930 substrate binding site [chemical binding]; other site 298653016931 activation loop (A-loop); other site 298653016932 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 298653016933 Interdomain contacts; other site 298653016934 Cytokine receptor motif; other site 298653016935 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 298653016936 Interdomain contacts; other site 298653016937 Cytokine receptor motif; other site 298653016938 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 298653016939 Interdomain contacts; other site 298653016940 Cytokine receptor motif; other site 298653016941 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 298653016942 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 298653016943 nucleotide binding site/active site [active] 298653016944 HIT family signature motif; other site 298653016945 catalytic residue [active] 298653016946 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653016947 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653016948 active site 298653016949 phosphorylation site [posttranslational modification] 298653016950 intermolecular recognition site; other site 298653016951 dimerization interface [polypeptide binding]; other site 298653016952 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653016953 DNA binding residues [nucleotide binding] 298653016954 dimerization interface [polypeptide binding]; other site 298653016955 Histidine kinase; Region: HisKA_3; pfam07730 298653016956 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653016957 ATP binding site [chemical binding]; other site 298653016958 G-X-G motif; other site 298653016959 yiaA/B two helix domain; Region: YiaAB; cl01759 298653016960 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 298653016961 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 298653016962 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 298653016963 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 298653016964 structural tetrad; other site 298653016965 PQQ-like domain; Region: PQQ_2; pfam13360 298653016966 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 298653016967 structural tetrad; other site 298653016968 FOG: WD40 repeat [General function prediction only]; Region: COG2319 298653016969 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 298653016970 structural tetrad; other site 298653016971 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 298653016972 minor groove reading motif; other site 298653016973 helix-hairpin-helix signature motif; other site 298653016974 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 298653016975 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 298653016976 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 298653016977 DNA binding residues [nucleotide binding] 298653016978 putative dimer interface [polypeptide binding]; other site 298653016979 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653016980 Uncharacterized conserved protein [Function unknown]; Region: COG3268 298653016981 NAD(P) binding site [chemical binding]; other site 298653016982 Cupin; Region: Cupin_6; pfam12852 298653016983 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 298653016984 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 298653016985 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653016986 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 298653016987 NAD(P) binding site [chemical binding]; other site 298653016988 active site 298653016989 Helix-turn-helix domain; Region: HTH_18; pfam12833 298653016990 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 298653016991 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 298653016992 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653016993 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653016994 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 298653016995 AAA domain; Region: AAA_14; pfam13173 298653016996 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 298653016997 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 298653016998 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 298653016999 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653017000 NAD(P) binding site [chemical binding]; other site 298653017001 active site 298653017002 Transcriptional regulators [Transcription]; Region: MarR; COG1846 298653017003 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 298653017004 YCII-related domain; Region: YCII; cl00999 298653017005 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 298653017006 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 298653017007 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 298653017008 TIGR03086 family protein; Region: TIGR03086 298653017009 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653017010 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653017011 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 298653017012 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 298653017013 AMP-binding enzyme; Region: AMP-binding; cl15778 298653017014 Nuclease-related domain; Region: NERD; pfam08378 298653017015 Transcriptional regulator [Transcription]; Region: LysR; COG0583 298653017016 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 298653017017 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 298653017018 putative substrate binding pocket [chemical binding]; other site 298653017019 putative dimerization interface [polypeptide binding]; other site 298653017020 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 298653017021 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 298653017022 FAD binding pocket [chemical binding]; other site 298653017023 FAD binding motif [chemical binding]; other site 298653017024 phosphate binding motif [ion binding]; other site 298653017025 NAD binding pocket [chemical binding]; other site 298653017026 Cupin domain; Region: Cupin_2; pfam07883 298653017027 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653017028 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653017029 NmrA-like family; Region: NmrA; pfam05368 298653017030 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 298653017031 NADP binding site [chemical binding]; other site 298653017032 active site 298653017033 regulatory binding site [polypeptide binding]; other site 298653017034 Predicted transcriptional regulators [Transcription]; Region: COG1733 298653017035 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 298653017036 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653017037 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 298653017038 Epoxide hydrolase N terminus; Region: EHN; pfam06441 298653017039 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653017040 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653017041 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 298653017042 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 298653017043 Methyltransferase domain; Region: Methyltransf_23; pfam13489 298653017044 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653017045 S-adenosylmethionine binding site [chemical binding]; other site 298653017046 Helix-turn-helix domain; Region: HTH_31; pfam13560 298653017047 Domain of unknown function (DUF397); Region: DUF397; pfam04149 298653017048 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 298653017049 SPFH domain / Band 7 family; Region: Band_7; pfam01145 298653017050 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 298653017051 nudix motif; other site 298653017052 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 298653017053 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 298653017054 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 298653017055 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653017056 NAD(P) binding site [chemical binding]; other site 298653017057 active site 298653017058 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 298653017059 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 298653017060 inhibitor-cofactor binding pocket; inhibition site 298653017061 pyridoxal 5'-phosphate binding site [chemical binding]; other site 298653017062 catalytic residue [active] 298653017063 Amidohydrolase; Region: Amidohydro_2; pfam04909 298653017064 DsrE/DsrF-like family; Region: DrsE; cl00672 298653017065 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 298653017066 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 298653017067 AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192 298653017068 AIR synthase-related protein, MSMEG_0567 C-terminal family; Region: MSMEG_0567_Cter; TIGR04050 298653017069 dimerization interface [polypeptide binding]; other site 298653017070 putative ATP binding site [chemical binding]; other site 298653017071 Predicted amidohydrolase [General function prediction only]; Region: COG0388 298653017072 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 298653017073 active site 298653017074 catalytic triad [active] 298653017075 dimer interface [polypeptide binding]; other site 298653017076 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 298653017077 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 298653017078 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653017079 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653017080 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 298653017081 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 298653017082 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 298653017083 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 298653017084 hydrophobic ligand binding site; other site 298653017085 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 298653017086 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 298653017087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653017088 ATP binding site [chemical binding]; other site 298653017089 Mg2+ binding site [ion binding]; other site 298653017090 G-X-G motif; other site 298653017091 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 298653017092 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 298653017093 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 298653017094 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 298653017095 RNA binding site [nucleotide binding]; other site 298653017096 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 298653017097 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 298653017098 Right handed beta helix region; Region: Beta_helix; pfam13229 298653017099 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 298653017100 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 298653017101 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 298653017102 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 298653017103 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 298653017104 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 298653017105 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 298653017106 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 298653017107 Walker A motif; other site 298653017108 ATP binding site [chemical binding]; other site 298653017109 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 298653017110 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 298653017111 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 298653017112 Mechanosensitive ion channel; Region: MS_channel; pfam00924 298653017113 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653017114 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653017115 Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862 298653017116 putative hydrophobic ligand binding site [chemical binding]; other site 298653017117 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 298653017118 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 298653017119 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 298653017120 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 298653017121 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653017122 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653017123 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 298653017124 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 298653017125 active site 298653017126 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 298653017127 Histidine kinase; Region: HisKA_3; pfam07730 298653017128 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 298653017129 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653017130 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 298653017131 active site 298653017132 dimerization interface [polypeptide binding]; other site 298653017133 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653017134 DNA binding residues [nucleotide binding] 298653017135 dimerization interface [polypeptide binding]; other site 298653017136 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 298653017137 AMP-binding enzyme; Region: AMP-binding; cl15778 298653017138 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 298653017139 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 298653017140 NAD(P) binding site [chemical binding]; other site 298653017141 catalytic residues [active] 298653017142 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 298653017143 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 298653017144 Histidine kinase; Region: HisKA_3; pfam07730 298653017145 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653017146 ATP binding site [chemical binding]; other site 298653017147 Mg2+ binding site [ion binding]; other site 298653017148 G-X-G motif; other site 298653017149 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653017150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653017151 active site 298653017152 phosphorylation site [posttranslational modification] 298653017153 intermolecular recognition site; other site 298653017154 dimerization interface [polypeptide binding]; other site 298653017155 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653017156 DNA binding residues [nucleotide binding] 298653017157 dimerization interface [polypeptide binding]; other site 298653017158 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 298653017159 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 298653017160 active site 298653017161 substrate binding site [chemical binding]; other site 298653017162 ATP binding site [chemical binding]; other site 298653017163 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653017164 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653017165 active site 298653017166 ATP binding site [chemical binding]; other site 298653017167 substrate binding site [chemical binding]; other site 298653017168 activation loop (A-loop); other site 298653017169 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 298653017170 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 298653017171 phosphopeptide binding site; other site 298653017172 ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR). DR is a well-described phenomenon occurring in fungi and shares several similarities with processes...; Region: ABCG_EPDR; cd03213 298653017173 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 298653017174 Walker A/P-loop; other site 298653017175 ATP binding site [chemical binding]; other site 298653017176 Q-loop/lid; other site 298653017177 ABC transporter signature motif; other site 298653017178 Walker B; other site 298653017179 D-loop; other site 298653017180 H-loop/switch region; other site 298653017181 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 298653017182 recombinase A; Provisional; Region: recA; PRK09354 298653017183 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 298653017184 hexamer interface [polypeptide binding]; other site 298653017185 Walker A motif; other site 298653017186 ATP binding site [chemical binding]; other site 298653017187 Walker B motif; other site 298653017188 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 298653017189 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 298653017190 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 298653017191 pyridoxal 5'-phosphate binding site [chemical binding]; other site 298653017192 homodimer interface [polypeptide binding]; other site 298653017193 catalytic residue [active] 298653017194 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 298653017195 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 298653017196 ATP-grasp domain; Region: ATP-grasp_4; cl03087 298653017197 Methyltransferase domain; Region: Methyltransf_23; pfam13489 298653017198 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653017199 S-adenosylmethionine binding site [chemical binding]; other site 298653017200 putative transposase OrfB; Reviewed; Region: PHA02517 298653017201 Integrase core domain; Region: rve; pfam00665 298653017202 Integrase core domain; Region: rve_3; pfam13683 298653017203 DDE superfamily endonuclease; Region: DDE_5; pfam13546 298653017204 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 298653017205 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 298653017206 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653017207 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653017208 active site 298653017209 ATP binding site [chemical binding]; other site 298653017210 substrate binding site [chemical binding]; other site 298653017211 activation loop (A-loop); other site 298653017212 Integrase core domain; Region: rve; pfam00665 298653017213 Integrase core domain; Region: rve_3; pfam13683 298653017214 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 298653017215 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 298653017216 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 298653017217 Int/Topo IB signature motif; other site 298653017218 Superfamily II helicase [General function prediction only]; Region: COG1204 298653017219 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 298653017220 ATP binding site [chemical binding]; other site 298653017221 putative Mg++ binding site [ion binding]; other site 298653017222 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653017223 Superfamily II helicase [General function prediction only]; Region: COG1204 298653017224 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 298653017225 ATP binding site [chemical binding]; other site 298653017226 putative Mg++ binding site [ion binding]; other site 298653017227 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 298653017228 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 298653017229 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 298653017230 Int/Topo IB signature motif; other site 298653017231 DNA methylase; Region: N6_N4_Mtase; pfam01555 298653017232 Methyltransferase domain; Region: Methyltransf_26; pfam13659 298653017233 AAA-like domain; Region: AAA_10; pfam12846 298653017234 Domain of unknown function DUF87; Region: DUF87; pfam01935 298653017235 Domain of unknown function DUF87; Region: DUF87; pfam01935 298653017236 AAA-like domain; Region: AAA_10; pfam12846 298653017237 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 298653017238 Replication-relaxation; Region: Replic_Relax; pfam13814 298653017239 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 298653017240 N-acetyl-D-glucosamine binding site [chemical binding]; other site 298653017241 catalytic residue [active] 298653017242 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 298653017243 NlpC/P60 family; Region: NLPC_P60; pfam00877 298653017244 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 298653017245 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 298653017246 Walker A motif; other site 298653017247 ATP binding site [chemical binding]; other site 298653017248 Walker B motif; other site 298653017249 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 298653017250 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 298653017251 putative active site [active] 298653017252 putative NTP binding site [chemical binding]; other site 298653017253 putative nucleic acid binding site [nucleotide binding]; other site 298653017254 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 298653017255 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 298653017256 Transposase; Region: DDE_Tnp_ISL3; pfam01610 298653017257 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 298653017258 Transposase; Region: DDE_Tnp_ISL3; pfam01610 298653017259 Domain of unknown function (DUF3560); Region: DUF3560; pfam12083 298653017260 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 298653017261 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 298653017262 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 298653017263 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 298653017264 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 298653017265 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 298653017266 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 298653017267 Leucine carboxyl methyltransferase; Region: LCM; cl01306 298653017268 TIR domain; Region: TIR_2; pfam13676 298653017269 FOG: WD40 repeat [General function prediction only]; Region: COG2319 298653017270 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 298653017271 structural tetrad; other site 298653017272 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 298653017273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653017274 S-adenosylmethionine binding site [chemical binding]; other site 298653017275 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 298653017276 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 298653017277 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 298653017278 active site 298653017279 zinc binding site [ion binding]; other site 298653017280 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 298653017281 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 298653017282 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 298653017283 FxLD family lantipeptide; Region: LD_lanti_pre; TIGR04363 298653017284 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 298653017285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653017286 S-adenosylmethionine binding site [chemical binding]; other site 298653017287 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 298653017288 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 298653017289 Bacterial transcriptional activator domain; Region: BTAD; smart01043 298653017290 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 298653017291 DDE superfamily endonuclease; Region: DDE_4; pfam13359 298653017292 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 298653017293 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 298653017294 motif II; other site 298653017295 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 298653017296 Lsr2; Region: Lsr2; pfam11774 298653017297 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 298653017298 putative catalytic site [active] 298653017299 putative metal binding site [ion binding]; other site 298653017300 putative phosphate binding site [ion binding]; other site 298653017301 Beta protein; Region: Beta_protein; pfam14350 298653017302 N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178 298653017303 PLD-like domain; Region: PLDc_2; pfam13091 298653017304 putative homodimer interface [polypeptide binding]; other site 298653017305 putative active site [active] 298653017306 catalytic site [active] 298653017307 DEAD-like helicases superfamily; Region: DEXDc; smart00487 298653017308 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 298653017309 ATP binding site [chemical binding]; other site 298653017310 putative Mg++ binding site [ion binding]; other site 298653017311 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 298653017312 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 298653017313 nucleotide binding region [chemical binding]; other site 298653017314 ATP-binding site [chemical binding]; other site 298653017315 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653017316 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653017317 active site 298653017318 ATP binding site [chemical binding]; other site 298653017319 substrate binding site [chemical binding]; other site 298653017320 activation loop (A-loop); other site 298653017321 FOG: WD40 repeat [General function prediction only]; Region: COG2319 298653017322 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 298653017323 structural tetrad; other site 298653017324 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 298653017325 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653017326 active site 298653017327 ATP binding site [chemical binding]; other site 298653017328 substrate binding site [chemical binding]; other site 298653017329 activation loop (A-loop); other site 298653017330 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 298653017331 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 298653017332 catalytic residues [active] 298653017333 Recombinase; Region: Recombinase; pfam07508 298653017334 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 298653017335 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 298653017336 DDE superfamily endonuclease; Region: DDE_4; cl15789 298653017337 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 298653017338 TIR domain; Region: TIR_2; pfam13676 298653017339 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 298653017340 structural tetrad; other site 298653017341 FOG: WD40 repeat [General function prediction only]; Region: COG2319 298653017342 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 298653017343 structural tetrad; other site 298653017344 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 298653017345 structural tetrad; other site 298653017346 DDE domain; Region: DDE_Tnp_IS240; pfam13610 298653017347 TIR domain; Region: TIR_2; pfam13676 298653017348 CHAT domain; Region: CHAT; pfam12770 298653017349 AAA ATPase domain; Region: AAA_16; pfam13191 298653017350 AAA domain; Region: AAA_22; pfam13401 298653017351 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653017352 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 298653017353 binding surface 298653017354 TPR motif; other site 298653017355 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653017356 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653017357 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 298653017358 binding surface 298653017359 TPR motif; other site 298653017360 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653017361 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653017362 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 298653017363 binding surface 298653017364 TPR motif; other site 298653017365 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653017366 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653017367 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 298653017368 putative active site; other site 298653017369 putative metal binding residues [ion binding]; other site 298653017370 signature motif; other site 298653017371 putative triphosphate binding site [ion binding]; other site 298653017372 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 298653017373 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653017374 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653017375 Protein of unknown function DUF72; Region: DUF72; cl00777 298653017376 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 298653017377 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 298653017378 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 298653017379 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 298653017380 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 298653017381 tetramer interface [polypeptide binding]; other site 298653017382 heme binding pocket [chemical binding]; other site 298653017383 NADPH binding site [chemical binding]; other site 298653017384 GAF domain; Region: GAF_2; pfam13185 298653017385 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 298653017386 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 298653017387 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653017388 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 298653017389 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 298653017390 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 298653017391 AAA ATPase domain; Region: AAA_16; pfam13191 298653017392 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653017393 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653017394 DNA binding residues [nucleotide binding] 298653017395 dimerization interface [polypeptide binding]; other site 298653017396 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 298653017397 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 298653017398 AAA ATPase domain; Region: AAA_16; pfam13191 298653017399 Mitochondrial ribosomal death-associated protein 3; Region: DAP3; pfam10236 298653017400 MMPL family; Region: MMPL; pfam03176 298653017401 MMPL family; Region: MMPL; pfam03176 298653017402 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 298653017403 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 298653017404 binding surface 298653017405 TPR motif; other site 298653017406 High-affinity nickel-transport protein; Region: NicO; cl00964 298653017407 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 298653017408 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 298653017409 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 298653017410 Probable Catalytic site; other site 298653017411 metal-binding site 298653017412 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 298653017413 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653017414 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 298653017415 classical (c) SDRs; Region: SDR_c; cd05233 298653017416 NAD(P) binding site [chemical binding]; other site 298653017417 active site 298653017418 Histidine kinase; Region: HisKA_3; pfam07730 298653017419 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653017420 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 298653017421 active site 298653017422 dimerization interface [polypeptide binding]; other site 298653017423 short chain dehydrogenase; Provisional; Region: PRK06197 298653017424 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 298653017425 putative NAD(P) binding site [chemical binding]; other site 298653017426 active site 298653017427 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653017428 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 298653017429 RNA binding surface [nucleotide binding]; other site 298653017430 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 298653017431 AMP-binding enzyme; Region: AMP-binding; pfam00501 298653017432 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653017433 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653017434 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 298653017435 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653017436 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 298653017437 Major Facilitator Superfamily; Region: MFS_1; pfam07690 298653017438 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653017439 putative substrate translocation pore; other site 298653017440 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653017441 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 298653017442 putative ligand binding site [chemical binding]; other site 298653017443 Carboxylesterase family; Region: COesterase; pfam00135 298653017444 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653017445 substrate binding pocket [chemical binding]; other site 298653017446 catalytic triad [active] 298653017447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653017448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653017449 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 298653017450 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 298653017451 mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253 298653017452 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653017453 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 298653017454 putative active site [active] 298653017455 putative catalytic site [active] 298653017456 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 298653017457 active site 2 [active] 298653017458 active site 1 [active] 298653017459 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 298653017460 classical (c) SDRs; Region: SDR_c; cd05233 298653017461 NAD(P) binding site [chemical binding]; other site 298653017462 active site 298653017463 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 298653017464 lipid-transfer protein; Provisional; Region: PRK07855 298653017465 active site 298653017466 DUF35 OB-fold domain; Region: DUF35; pfam01796 298653017467 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 298653017468 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653017469 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653017470 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653017471 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653017472 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653017473 Amidohydrolase; Region: Amidohydro_2; pfam04909 298653017474 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 298653017475 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 298653017476 active site 298653017477 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 298653017478 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 298653017479 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 298653017480 dimer interface [polypeptide binding]; other site 298653017481 PYR/PP interface [polypeptide binding]; other site 298653017482 TPP binding site [chemical binding]; other site 298653017483 substrate binding site [chemical binding]; other site 298653017484 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 298653017485 TPP-binding site [chemical binding]; other site 298653017486 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 298653017487 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 298653017488 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 298653017489 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 298653017490 active site 298653017491 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 298653017492 Probable transposase; Region: OrfB_IS605; pfam01385 298653017493 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 298653017494 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 298653017495 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 298653017496 NAD binding site [chemical binding]; other site 298653017497 catalytic Zn binding site [ion binding]; other site 298653017498 substrate binding site [chemical binding]; other site 298653017499 structural Zn binding site [ion binding]; other site 298653017500 short chain dehydrogenase; Provisional; Region: PRK08278 298653017501 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653017502 NAD(P) binding site [chemical binding]; other site 298653017503 active site 298653017504 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 298653017505 SnoaL-like domain; Region: SnoaL_2; pfam12680 298653017506 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 298653017507 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 298653017508 [2Fe-2S] cluster binding site [ion binding]; other site 298653017509 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 298653017510 putative alpha subunit interface [polypeptide binding]; other site 298653017511 putative active site [active] 298653017512 putative substrate binding site [chemical binding]; other site 298653017513 Fe binding site [ion binding]; other site 298653017514 Amidohydrolase; Region: Amidohydro_2; pfam04909 298653017515 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653017516 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 298653017517 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653017518 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 298653017519 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653017520 active site 298653017521 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653017522 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653017523 active site 298653017524 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653017525 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 298653017526 active site 298653017527 Transcriptional regulators [Transcription]; Region: FadR; COG2186 298653017528 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 298653017529 DNA-binding site [nucleotide binding]; DNA binding site 298653017530 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 298653017531 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653017532 NAD(P) binding site [chemical binding]; other site 298653017533 active site 298653017534 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 298653017535 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 298653017536 active site 298653017537 putative substrate binding pocket [chemical binding]; other site 298653017538 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 298653017539 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653017540 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 298653017541 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 298653017542 NAD binding site [chemical binding]; other site 298653017543 catalytic residues [active] 298653017544 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 298653017545 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 298653017546 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 298653017547 NAD(P) binding site [chemical binding]; other site 298653017548 catalytic residues [active] 298653017549 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653017550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653017551 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 298653017552 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 298653017553 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 298653017554 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 298653017555 AsnC family; Region: AsnC_trans_reg; pfam01037 298653017556 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 298653017557 Domain of unknown function (DUF222); Region: DUF222; pfam02720 298653017558 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 298653017559 active site 298653017560 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 298653017561 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 298653017562 4Fe-4S binding domain; Region: Fer4; pfam00037 298653017563 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 298653017564 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 298653017565 TPP-binding site [chemical binding]; other site 298653017566 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 298653017567 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 298653017568 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 298653017569 dimer interface [polypeptide binding]; other site 298653017570 PYR/PP interface [polypeptide binding]; other site 298653017571 TPP binding site [chemical binding]; other site 298653017572 substrate binding site [chemical binding]; other site 298653017573 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 298653017574 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 298653017575 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 298653017576 catalytic residue [active] 298653017577 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 298653017578 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 298653017579 ATP binding site [chemical binding]; other site 298653017580 substrate interface [chemical binding]; other site 298653017581 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 298653017582 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 298653017583 NifU-like domain; Region: NifU; cl00484 298653017584 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 298653017585 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 298653017586 FeS/SAM binding site; other site 298653017587 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 298653017588 NifZ domain; Region: NifZ; pfam04319 298653017589 Nitrogen fixation protein NifW; Region: NifW; pfam03206 298653017590 Rop-like; Region: Rop-like; pfam05082 298653017591 Protein of unknown function, DUF269; Region: DUF269; pfam03270 298653017592 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 298653017593 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 298653017594 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 298653017595 nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478 298653017596 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 298653017597 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 298653017598 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 298653017599 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 298653017600 MoFe protein beta/alpha subunit interactions; other site 298653017601 Beta subunit P cluster binding residues; other site 298653017602 MoFe protein beta subunit/Fe protein contacts; other site 298653017603 MoFe protein dimer/ dimer interactions; other site 298653017604 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 298653017605 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 298653017606 MoFe protein alpha/beta subunit interactions; other site 298653017607 Alpha subunit P cluster binding residues; other site 298653017608 FeMoco binding residues [chemical binding]; other site 298653017609 MoFe protein alpha subunit/Fe protein contacts; other site 298653017610 MoFe protein dimer/ dimer interactions; other site 298653017611 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family; Region: Fer4_NifH; pfam00142 298653017612 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 298653017613 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 298653017614 iron-sulfur cluster [ion binding]; other site 298653017615 [2Fe-2S] cluster binding site [ion binding]; other site 298653017616 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 298653017617 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 298653017618 phosphopeptide binding site; other site 298653017619 Possibl zinc metallo-peptidase; Region: DUF1025; pfam06262 298653017620 TIR domain; Region: TIR_2; pfam13676 298653017621 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 298653017622 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 298653017623 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653017624 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 298653017625 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 298653017626 Coenzyme A binding pocket [chemical binding]; other site 298653017627 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 298653017628 Mechanosensitive ion channel; Region: MS_channel; pfam00924 298653017629 Predicted membrane protein [Function unknown]; Region: COG2261 298653017630 amidase; Provisional; Region: PRK06061 298653017631 Amidase; Region: Amidase; pfam01425 298653017632 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 298653017633 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 298653017634 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 298653017635 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 298653017636 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 298653017637 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 298653017638 pyridoxal 5'-phosphate binding site [chemical binding]; other site 298653017639 catalytic residue [active] 298653017640 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 298653017641 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 298653017642 phosphorylation site [posttranslational modification] 298653017643 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 298653017644 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 298653017645 NAD binding site [chemical binding]; other site 298653017646 catalytic residues [active] 298653017647 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 298653017648 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653017649 classical (c) SDRs; Region: SDR_c; cd05233 298653017650 NAD(P) binding site [chemical binding]; other site 298653017651 active site 298653017652 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 298653017653 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653017654 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 298653017655 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653017656 substrate binding site [chemical binding]; other site 298653017657 trimer interface [polypeptide binding]; other site 298653017658 oxyanion hole (OAH) forming residues; other site 298653017659 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 298653017660 CoA-transferase family III; Region: CoA_transf_3; pfam02515 298653017661 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 298653017662 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 298653017663 [2Fe-2S] cluster binding site [ion binding]; other site 298653017664 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 298653017665 alpha subunit interface [polypeptide binding]; other site 298653017666 active site 298653017667 substrate binding site [chemical binding]; other site 298653017668 Fe binding site [ion binding]; other site 298653017669 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 298653017670 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 298653017671 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653017672 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653017673 NAD(P) binding site [chemical binding]; other site 298653017674 active site 298653017675 SnoaL-like domain; Region: SnoaL_2; pfam12680 298653017676 Amidohydrolase; Region: Amidohydro_2; pfam04909 298653017677 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 298653017678 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 298653017679 putative active site [active] 298653017680 putative substrate binding site [chemical binding]; other site 298653017681 ATP binding site [chemical binding]; other site 298653017682 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653017683 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653017684 active site 298653017685 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 298653017686 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 298653017687 substrate binding site [chemical binding]; other site 298653017688 oxyanion hole (OAH) forming residues; other site 298653017689 trimer interface [polypeptide binding]; other site 298653017690 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653017691 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653017692 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653017693 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653017694 active site 298653017695 Domain of unknown function (DUF222); Region: DUF222; pfam02720 298653017696 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 298653017697 active site 298653017698 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 298653017699 classical (c) SDRs; Region: SDR_c; cd05233 298653017700 NAD(P) binding site [chemical binding]; other site 298653017701 active site 298653017702 Transcriptional regulators [Transcription]; Region: PurR; COG1609 298653017703 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 298653017704 DNA binding site [nucleotide binding] 298653017705 domain linker motif; other site 298653017706 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 298653017707 dimerization interface [polypeptide binding]; other site 298653017708 ligand binding site [chemical binding]; other site 298653017709 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 298653017710 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653017711 Helicase associated domain; Region: HA; pfam03457 298653017712 putative phosphoketolase; Provisional; Region: PRK05261 298653017713 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 298653017714 TPP-binding site [chemical binding]; other site 298653017715 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 298653017716 XFP C-terminal domain; Region: XFP_C; pfam09363 298653017717 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 298653017718 Phosphotransferase enzyme family; Region: APH; pfam01636 298653017719 AAA domain; Region: AAA_33; pfam13671 298653017720 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653017721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653017722 active site 298653017723 phosphorylation site [posttranslational modification] 298653017724 intermolecular recognition site; other site 298653017725 dimerization interface [polypeptide binding]; other site 298653017726 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653017727 DNA binding residues [nucleotide binding] 298653017728 dimerization interface [polypeptide binding]; other site 298653017729 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 298653017730 GAF domain; Region: GAF; cl15785 298653017731 GAF domain; Region: GAF_2; pfam13185 298653017732 GAF domain; Region: GAF_3; pfam13492 298653017733 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 298653017734 Histidine kinase; Region: HisKA_3; pfam07730 298653017735 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 298653017736 FOG: CBS domain [General function prediction only]; Region: COG0517 298653017737 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 298653017738 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 298653017739 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 298653017740 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 298653017741 phosphoenolpyruvate synthase; Validated; Region: PRK06464 298653017742 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 298653017743 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 298653017744 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 298653017745 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 298653017746 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 298653017747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653017748 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 298653017749 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653017750 active site 298653017751 phosphorylation site [posttranslational modification] 298653017752 intermolecular recognition site; other site 298653017753 dimerization interface [polypeptide binding]; other site 298653017754 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 298653017755 DNA binding site [nucleotide binding] 298653017756 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 298653017757 dimerization interface [polypeptide binding]; other site 298653017758 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 298653017759 dimer interface [polypeptide binding]; other site 298653017760 phosphorylation site [posttranslational modification] 298653017761 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653017762 ATP binding site [chemical binding]; other site 298653017763 Mg2+ binding site [ion binding]; other site 298653017764 G-X-G motif; other site 298653017765 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653017766 NAD(P) binding site [chemical binding]; other site 298653017767 active site 298653017768 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 298653017769 Acyltransferase family; Region: Acyl_transf_3; pfam01757 298653017770 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 298653017771 Acyltransferase family; Region: Acyl_transf_3; pfam01757 298653017772 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 298653017773 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653017774 MoxR-like ATPases [General function prediction only]; Region: COG0714 298653017775 NB-ARC domain; Region: NB-ARC; pfam00931 298653017776 Tetratricopeptide repeat; Region: TPR_10; pfam13374 298653017777 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653017778 Tetratricopeptide repeat; Region: TPR_12; pfam13424 298653017779 Tetratricopeptide repeat; Region: TPR_10; pfam13374 298653017780 Tetratricopeptide repeat; Region: TPR_10; pfam13374 298653017781 HEXXH motif domain; Region: mod_HExxH; TIGR04267 298653017782 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 298653017783 classical (c) SDRs; Region: SDR_c; cd05233 298653017784 NAD(P) binding site [chemical binding]; other site 298653017785 active site 298653017786 Cupin domain; Region: Cupin_2; pfam07883 298653017787 HlyD family secretion protein; Region: HlyD_3; pfam13437 298653017788 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 298653017789 FtsX-like permease family; Region: FtsX; pfam02687 298653017790 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 298653017791 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 298653017792 Walker A/P-loop; other site 298653017793 ATP binding site [chemical binding]; other site 298653017794 Q-loop/lid; other site 298653017795 ABC transporter signature motif; other site 298653017796 Walker B; other site 298653017797 D-loop; other site 298653017798 H-loop/switch region; other site 298653017799 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 298653017800 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 298653017801 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653017802 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 298653017803 Transcriptional regulator [Transcription]; Region: IclR; COG1414 298653017804 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 298653017805 Bacterial transcriptional regulator; Region: IclR; pfam01614 298653017806 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 298653017807 active site 298653017808 Domain of unknown function (DUF336); Region: DUF336; cl01249 298653017809 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 298653017810 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 298653017811 putative di-iron ligands [ion binding]; other site 298653017812 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 298653017813 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 298653017814 FAD binding pocket [chemical binding]; other site 298653017815 FAD binding motif [chemical binding]; other site 298653017816 phosphate binding motif [ion binding]; other site 298653017817 beta-alpha-beta structure motif; other site 298653017818 NAD binding pocket [chemical binding]; other site 298653017819 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 298653017820 catalytic loop [active] 298653017821 iron binding site [ion binding]; other site 298653017822 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 298653017823 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 298653017824 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 298653017825 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 298653017826 DNA binding residues [nucleotide binding] 298653017827 drug binding residues [chemical binding]; other site 298653017828 dimer interface [polypeptide binding]; other site 298653017829 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 298653017830 short chain dehydrogenase; Provisional; Region: PRK06523 298653017831 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653017832 NAD(P) binding site [chemical binding]; other site 298653017833 active site 298653017834 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 298653017835 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653017836 active site 298653017837 phosphorylation site [posttranslational modification] 298653017838 intermolecular recognition site; other site 298653017839 dimerization interface [polypeptide binding]; other site 298653017840 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 298653017841 DNA binding site [nucleotide binding] 298653017842 CBD_II domain; Region: CBD_II; smart00637 298653017843 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 298653017844 active site 298653017845 glycoside hydrolase family 64: laminaripentaose-producing, beta-1,3-glucanase (LPHase)-like; Region: GH64-LPHase-like; cd09216 298653017846 substrate binding pocket [chemical binding]; other site 298653017847 catalytic residues [active] 298653017848 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 298653017849 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 298653017850 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 298653017851 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 298653017852 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 298653017853 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 298653017854 EthD domain; Region: EthD; pfam07110 298653017855 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 298653017856 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 298653017857 dimerization interface [polypeptide binding]; other site 298653017858 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 298653017859 dimerization interface [polypeptide binding]; other site 298653017860 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 298653017861 dimerization interface [polypeptide binding]; other site 298653017862 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 298653017863 dimerization interface [polypeptide binding]; other site 298653017864 GAF domain; Region: GAF_2; pfam13185 298653017865 GAF domain; Region: GAF; pfam01590 298653017866 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 298653017867 dimer interface [polypeptide binding]; other site 298653017868 phosphorylation site [posttranslational modification] 298653017869 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653017870 ATP binding site [chemical binding]; other site 298653017871 Mg2+ binding site [ion binding]; other site 298653017872 G-X-G motif; other site 298653017873 Response regulator receiver domain; Region: Response_reg; pfam00072 298653017874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653017875 active site 298653017876 phosphorylation site [posttranslational modification] 298653017877 intermolecular recognition site; other site 298653017878 dimerization interface [polypeptide binding]; other site 298653017879 ANTAR domain; Region: ANTAR; pfam03861 298653017880 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 298653017881 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 298653017882 putative metal binding site [ion binding]; other site 298653017883 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 298653017884 putative metal binding site [ion binding]; other site 298653017885 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 298653017886 rod shape-determining protein MreB; Provisional; Region: PRK13930 298653017887 nucleotide binding site [chemical binding]; other site 298653017888 putative NEF/HSP70 interaction site [polypeptide binding]; other site 298653017889 SBD interface [polypeptide binding]; other site 298653017890 CHAT domain; Region: CHAT; pfam12770 298653017891 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 298653017892 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 298653017893 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 298653017894 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 298653017895 Imelysin; Region: Peptidase_M75; pfam09375 298653017896 Iron permease FTR1 family; Region: FTR1; pfam03239 298653017897 Helix-turn-helix domains; Region: HTH; cl00088 298653017898 Beta-lactamase; Region: Beta-lactamase; pfam00144 298653017899 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 298653017900 putative transposase OrfB; Reviewed; Region: PHA02517 298653017901 Homeodomain-like domain; Region: HTH_32; pfam13565 298653017902 Integrase core domain; Region: rve; pfam00665 298653017903 Integrase core domain; Region: rve_3; pfam13683 298653017904 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 298653017905 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 298653017906 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 298653017907 shikimate binding site; other site 298653017908 NAD(P) binding site [chemical binding]; other site 298653017909 Transcriptional regulators [Transcription]; Region: PurR; COG1609 298653017910 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 298653017911 DNA binding site [nucleotide binding] 298653017912 domain linker motif; other site 298653017913 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 298653017914 dimerization interface [polypeptide binding]; other site 298653017915 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 298653017916 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 298653017917 dimer interface [polypeptide binding]; other site 298653017918 TPP-binding site [chemical binding]; other site 298653017919 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 298653017920 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 298653017921 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 298653017922 active site 298653017923 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 298653017924 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 298653017925 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 298653017926 active site 298653017927 intersubunit interface [polypeptide binding]; other site 298653017928 catalytic residue [active] 298653017929 6-phosphogluconate dehydratase; Region: edd; TIGR01196 298653017930 phosphogluconate dehydratase; Validated; Region: PRK09054 298653017931 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 298653017932 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 298653017933 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 298653017934 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 298653017935 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 298653017936 putative substrate binding site [chemical binding]; other site 298653017937 putative ATP binding site [chemical binding]; other site 298653017938 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 298653017939 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 298653017940 Walker A/P-loop; other site 298653017941 ATP binding site [chemical binding]; other site 298653017942 Q-loop/lid; other site 298653017943 ABC transporter signature motif; other site 298653017944 Walker B; other site 298653017945 D-loop; other site 298653017946 H-loop/switch region; other site 298653017947 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 298653017948 TM-ABC transporter signature motif; other site 298653017949 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 298653017950 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 298653017951 ligand binding site [chemical binding]; other site 298653017952 Transcriptional regulators [Transcription]; Region: PurR; COG1609 298653017953 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 298653017954 DNA binding site [nucleotide binding] 298653017955 domain linker motif; other site 298653017956 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 298653017957 dimerization interface [polypeptide binding]; other site 298653017958 ligand binding site [chemical binding]; other site 298653017959 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 298653017960 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 298653017961 putative ligand binding site [chemical binding]; other site 298653017962 Transposase; Region: DDE_Tnp_ISL3; pfam01610 298653017963 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 298653017964 PAS fold; Region: PAS; pfam00989 298653017965 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 298653017966 putative active site [active] 298653017967 heme pocket [chemical binding]; other site 298653017968 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653017969 metal binding site [ion binding]; metal-binding site 298653017970 active site 298653017971 I-site; other site 298653017972 PAS fold; Region: PAS; pfam00989 298653017973 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 298653017974 putative active site [active] 298653017975 heme pocket [chemical binding]; other site 298653017976 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653017977 metal binding site [ion binding]; metal-binding site 298653017978 active site 298653017979 I-site; other site 298653017980 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 298653017981 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 298653017982 ligand binding site [chemical binding]; other site 298653017983 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 298653017984 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 298653017985 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 298653017986 substrate binding [chemical binding]; other site 298653017987 active site 298653017988 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 298653017989 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 298653017990 active site 298653017991 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 298653017992 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 298653017993 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 298653017994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653017995 dimer interface [polypeptide binding]; other site 298653017996 conserved gate region; other site 298653017997 putative PBP binding loops; other site 298653017998 ABC-ATPase subunit interface; other site 298653017999 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 298653018000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653018001 ABC-ATPase subunit interface; other site 298653018002 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 298653018003 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 298653018004 Transcriptional regulators [Transcription]; Region: PurR; COG1609 298653018005 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 298653018006 DNA binding site [nucleotide binding] 298653018007 domain linker motif; other site 298653018008 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 298653018009 putative ligand binding site [chemical binding]; other site 298653018010 putative dimerization interface [polypeptide binding]; other site 298653018011 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 298653018012 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 298653018013 Walker A/P-loop; other site 298653018014 ATP binding site [chemical binding]; other site 298653018015 Q-loop/lid; other site 298653018016 ABC transporter signature motif; other site 298653018017 Walker B; other site 298653018018 D-loop; other site 298653018019 H-loop/switch region; other site 298653018020 TOBE domain; Region: TOBE; pfam03459 298653018021 Integrase core domain; Region: rve_3; pfam13683 298653018022 HTH-like domain; Region: HTH_21; pfam13276 298653018023 Integrase core domain; Region: rve; pfam00665 298653018024 Transposase; Region: HTH_Tnp_1; pfam01527 298653018025 Transcriptional regulators [Transcription]; Region: PurR; COG1609 298653018026 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 298653018027 DNA binding site [nucleotide binding] 298653018028 domain linker motif; other site 298653018029 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 298653018030 putative dimerization interface [polypeptide binding]; other site 298653018031 putative ligand binding site [chemical binding]; other site 298653018032 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 298653018033 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 298653018034 substrate binding [chemical binding]; other site 298653018035 active site 298653018036 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 298653018037 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 298653018038 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 298653018039 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 298653018040 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653018041 dimer interface [polypeptide binding]; other site 298653018042 conserved gate region; other site 298653018043 putative PBP binding loops; other site 298653018044 ABC-ATPase subunit interface; other site 298653018045 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 298653018046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 298653018047 dimer interface [polypeptide binding]; other site 298653018048 conserved gate region; other site 298653018049 putative PBP binding loops; other site 298653018050 ABC-ATPase subunit interface; other site 298653018051 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 298653018052 Transcriptional regulators [Transcription]; Region: PurR; COG1609 298653018053 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 298653018054 DNA binding site [nucleotide binding] 298653018055 domain linker motif; other site 298653018056 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 298653018057 putative dimerization interface [polypeptide binding]; other site 298653018058 putative ligand binding site [chemical binding]; other site 298653018059 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 298653018060 active site 298653018061 Integrase core domain; Region: rve_3; pfam13683 298653018062 HTH-like domain; Region: HTH_21; pfam13276 298653018063 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 298653018064 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 298653018065 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 298653018066 shikimate binding site; other site 298653018067 NAD(P) binding site [chemical binding]; other site 298653018068 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 298653018069 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 298653018070 Restriction endonuclease; Region: Mrr_cat; pfam04471 298653018071 DDE superfamily endonuclease; Region: DDE_4; cl15789 298653018072 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 298653018073 active site 298653018074 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 298653018075 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 298653018076 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 298653018077 active site 298653018078 intersubunit interface [polypeptide binding]; other site 298653018079 catalytic residue [active] 298653018080 6-phosphogluconate dehydratase; Region: edd; TIGR01196 298653018081 phosphogluconate dehydratase; Validated; Region: PRK09054 298653018082 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 298653018083 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 298653018084 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 298653018085 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 298653018086 dimerization domain swap beta strand [polypeptide binding]; other site 298653018087 regulatory protein interface [polypeptide binding]; other site 298653018088 active site 298653018089 regulatory phosphorylation site [posttranslational modification]; other site 298653018090 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 298653018091 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 298653018092 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 298653018093 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 298653018094 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 298653018095 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 298653018096 putative NAD(P) binding site [chemical binding]; other site 298653018097 catalytic Zn binding site [ion binding]; other site 298653018098 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 298653018099 active site 298653018100 phosphorylation site [posttranslational modification] 298653018101 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 298653018102 active site 298653018103 P-loop; other site 298653018104 phosphorylation site [posttranslational modification] 298653018105 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 298653018106 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 298653018107 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 298653018108 putative substrate binding site [chemical binding]; other site 298653018109 putative ATP binding site [chemical binding]; other site 298653018110 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 298653018111 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 298653018112 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 298653018113 Helix-turn-helix domains; Region: HTH; cl00088 298653018114 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 298653018115 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 298653018116 catalytic core [active] 298653018117 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653018118 active site 298653018119 substrate binding site [chemical binding]; other site 298653018120 activation loop (A-loop); other site 298653018121 AAA ATPase domain; Region: AAA_16; pfam13191 298653018122 Predicted ATPase [General function prediction only]; Region: COG3899 298653018123 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 298653018124 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 298653018125 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 298653018126 metal binding site [ion binding]; metal-binding site 298653018127 active site 298653018128 I-site; other site 298653018129 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 298653018130 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 298653018131 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 298653018132 Calcium binding; Region: Calci_bind_CcbP; pfam11535 298653018133 Integrase core domain; Region: rve; pfam00665 298653018134 DDE domain; Region: DDE_Tnp_IS240; pfam13610 298653018135 AAA ATPase domain; Region: AAA_16; pfam13191 298653018136 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 298653018137 structural tetrad; other site 298653018138 FOG: WD40 repeat [General function prediction only]; Region: COG2319 298653018139 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 298653018140 structural tetrad; other site 298653018141 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 298653018142 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653018143 active site 298653018144 ATP binding site [chemical binding]; other site 298653018145 substrate binding site [chemical binding]; other site 298653018146 activation loop (A-loop); other site 298653018147 NHL repeat; Region: NHL; pfam01436 298653018148 NHL repeat; Region: NHL; pfam01436 298653018149 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 298653018150 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 298653018151 SnoaL-like domain; Region: SnoaL_4; pfam13577 298653018152 Uncharacterized conserved protein [Function unknown]; Region: COG2128 298653018153 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 298653018154 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 298653018155 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 298653018156 active site 298653018157 metal binding site [ion binding]; metal-binding site 298653018158 Homeodomain-like domain; Region: HTH_23; pfam13384 298653018159 Winged helix-turn helix; Region: HTH_29; pfam13551 298653018160 Homeodomain-like domain; Region: HTH_32; pfam13565 298653018161 DDE superfamily endonuclease; Region: DDE_3; pfam13358 298653018162 Homeodomain-like domain; Region: HTH_23; pfam13384 298653018163 Winged helix-turn helix; Region: HTH_29; pfam13551 298653018164 Homeodomain-like domain; Region: HTH_32; pfam13565 298653018165 DDE superfamily endonuclease; Region: DDE_3; pfam13358 298653018166 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 298653018167 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653018168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653018169 NAD(P) binding site [chemical binding]; other site 298653018170 active site 298653018171 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 298653018172 classical (c) SDRs; Region: SDR_c; cd05233 298653018173 NAD(P) binding site [chemical binding]; other site 298653018174 active site 298653018175 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 298653018176 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653018177 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653018178 NAD(P) binding site [chemical binding]; other site 298653018179 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 298653018180 Amidohydrolase; Region: Amidohydro_2; pfam04909 298653018181 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 298653018182 Histidine kinase; Region: HisKA_3; pfam07730 298653018183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653018184 ATP binding site [chemical binding]; other site 298653018185 Mg2+ binding site [ion binding]; other site 298653018186 G-X-G motif; other site 298653018187 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 298653018188 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 298653018189 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 298653018190 active site 298653018191 iron coordination sites [ion binding]; other site 298653018192 substrate binding pocket [chemical binding]; other site 298653018193 DDE superfamily endonuclease; Region: DDE_5; pfam13546 298653018194 Integrase core domain; Region: rve; pfam00665 298653018195 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 298653018196 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 298653018197 MMPL family; Region: MMPL; pfam03176 298653018198 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 298653018199 Histidine kinase; Region: HisKA_3; pfam07730 298653018200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653018201 ATP binding site [chemical binding]; other site 298653018202 Mg2+ binding site [ion binding]; other site 298653018203 G-X-G motif; other site 298653018204 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653018205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653018206 active site 298653018207 phosphorylation site [posttranslational modification] 298653018208 intermolecular recognition site; other site 298653018209 dimerization interface [polypeptide binding]; other site 298653018210 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653018211 DNA binding residues [nucleotide binding] 298653018212 dimerization interface [polypeptide binding]; other site 298653018213 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 298653018214 NlpC/P60 family; Region: NLPC_P60; pfam00877 298653018215 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 298653018216 DNA binding site [nucleotide binding] 298653018217 active site 298653018218 Int/Topo IB signature motif; other site 298653018219 Transposase; Region: DEDD_Tnp_IS110; pfam01548 298653018220 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 298653018221 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 298653018222 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 298653018223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 298653018224 putative substrate translocation pore; other site 298653018225 FOG: WD40 repeat [General function prediction only]; Region: COG2319 298653018226 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 298653018227 structural tetrad; other site 298653018228 FOG: WD40 repeat [General function prediction only]; Region: COG2319 298653018229 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 298653018230 structural tetrad; other site 298653018231 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653018232 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653018233 active site 298653018234 ATP binding site [chemical binding]; other site 298653018235 substrate binding site [chemical binding]; other site 298653018236 activation loop (A-loop); other site 298653018237 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 298653018238 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 298653018239 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 298653018240 putative active site [active] 298653018241 heme pocket [chemical binding]; other site 298653018242 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 298653018243 dimer interface [polypeptide binding]; other site 298653018244 phosphorylation site [posttranslational modification] 298653018245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653018246 ATP binding site [chemical binding]; other site 298653018247 Mg2+ binding site [ion binding]; other site 298653018248 G-X-G motif; other site 298653018249 Response regulator receiver domain; Region: Response_reg; pfam00072 298653018250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653018251 active site 298653018252 phosphorylation site [posttranslational modification] 298653018253 intermolecular recognition site; other site 298653018254 dimerization interface [polypeptide binding]; other site 298653018255 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 298653018256 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 298653018257 putative active site [active] 298653018258 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 298653018259 dimer interface [polypeptide binding]; other site 298653018260 phosphorylation site [posttranslational modification] 298653018261 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653018262 ATP binding site [chemical binding]; other site 298653018263 G-X-G motif; other site 298653018264 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 298653018265 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 298653018266 DNA binding site [nucleotide binding] 298653018267 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 298653018268 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653018269 active site 298653018270 phosphorylation site [posttranslational modification] 298653018271 intermolecular recognition site; other site 298653018272 dimerization interface [polypeptide binding]; other site 298653018273 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 298653018274 DNA binding site [nucleotide binding] 298653018275 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 298653018276 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 298653018277 dimerization interface [polypeptide binding]; other site 298653018278 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 298653018279 dimer interface [polypeptide binding]; other site 298653018280 phosphorylation site [posttranslational modification] 298653018281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653018282 ATP binding site [chemical binding]; other site 298653018283 Mg2+ binding site [ion binding]; other site 298653018284 G-X-G motif; other site 298653018285 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 298653018286 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 298653018287 active site 298653018288 homodimer interface [polypeptide binding]; other site 298653018289 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 298653018290 D-alanine--D-lactate ligase; Provisional; Region: vanB; PRK14568 298653018291 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 298653018292 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 298653018293 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 298653018294 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; pfam02826 298653018295 NAD+ binding site [chemical binding]; other site 298653018296 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 298653018297 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 298653018298 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 298653018299 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 298653018300 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 298653018301 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 298653018302 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 298653018303 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 298653018304 Divergent AAA domain; Region: AAA_4; pfam04326 298653018305 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 298653018306 dimerization interface [polypeptide binding]; other site 298653018307 putative DNA binding site [nucleotide binding]; other site 298653018308 Helix-turn-helix domains; Region: HTH; cl00088 298653018309 putative Zn2+ binding site [ion binding]; other site 298653018310 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 298653018311 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_16; cd04674 298653018312 nudix motif; other site 298653018313 nudix motif; other site 298653018314 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 298653018315 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 298653018316 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 298653018317 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653018318 NAD(P) binding site [chemical binding]; other site 298653018319 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 298653018320 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653018321 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 298653018322 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 298653018323 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653018324 SnoaL-like domain; Region: SnoaL_4; pfam13577 298653018325 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 298653018326 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 298653018327 putative NAD(P) binding site [chemical binding]; other site 298653018328 catalytic Zn binding site [ion binding]; other site 298653018329 MMPL family; Region: MMPL; pfam03176 298653018330 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 298653018331 DDE superfamily endonuclease; Region: DDE_3; pfam13358 298653018332 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 298653018333 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 298653018334 Homeodomain-like domain; Region: HTH_32; pfam13565 298653018335 Winged helix-turn helix; Region: HTH_33; pfam13592 298653018336 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 298653018337 Histidine kinase; Region: HisKA_3; pfam07730 298653018338 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 298653018339 ATP binding site [chemical binding]; other site 298653018340 Mg2+ binding site [ion binding]; other site 298653018341 G-X-G motif; other site 298653018342 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653018343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653018344 active site 298653018345 phosphorylation site [posttranslational modification] 298653018346 intermolecular recognition site; other site 298653018347 dimerization interface [polypeptide binding]; other site 298653018348 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653018349 DNA binding residues [nucleotide binding] 298653018350 dimerization interface [polypeptide binding]; other site 298653018351 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653018352 S-adenosylmethionine binding site [chemical binding]; other site 298653018353 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 298653018354 DNA-binding site [nucleotide binding]; DNA binding site 298653018355 RNA-binding motif; other site 298653018356 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 298653018357 nucleotide binding region [chemical binding]; other site 298653018358 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 298653018359 ATP-binding site [chemical binding]; other site 298653018360 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 298653018361 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 298653018362 Berberine and berberine like; Region: BBE; pfam08031 298653018363 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 298653018364 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653018365 DNA binding residues [nucleotide binding] 298653018366 dimerization interface [polypeptide binding]; other site 298653018367 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653018368 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 298653018369 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 298653018370 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 298653018371 substrate binding site [chemical binding]; other site 298653018372 activation loop (A-loop); other site 298653018373 Protein phosphatase 2C; Region: PP2C_2; pfam13672 298653018374 active site 298653018375 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 298653018376 metal ion-dependent adhesion site (MIDAS); other site 298653018377 Protein of unknown function (DUF3633); Region: DUF3633; pfam12315 298653018378 Dynamin family; Region: Dynamin_N; pfam00350 298653018379 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 298653018380 Protein phosphatase 2C; Region: PP2C_2; pfam13672 298653018381 Amidohydrolase; Region: Amidohydro_2; pfam04909 298653018382 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 298653018383 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 298653018384 classical (c) SDRs; Region: SDR_c; cd05233 298653018385 NAD(P) binding site [chemical binding]; other site 298653018386 active site 298653018387 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 298653018388 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 298653018389 NAD(P) binding site [chemical binding]; other site 298653018390 catalytic residues [active] 298653018391 cytokinin dehydrogenase; Region: PLN02441 298653018392 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 298653018393 DNA binding site [nucleotide binding] 298653018394 Bacterial transcriptional activator domain; Region: BTAD; smart01043 298653018395 AAA ATPase domain; Region: AAA_16; pfam13191 298653018396 SnoaL-like domain; Region: SnoaL_4; pfam13577 298653018397 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 298653018398 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 298653018399 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 298653018400 P-loop; other site 298653018401 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 298653018402 putative FMN binding site [chemical binding]; other site 298653018403 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 298653018404 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 298653018405 dimer interface [polypeptide binding]; other site 298653018406 active site 298653018407 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 298653018408 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 298653018409 DXD motif; other site 298653018410 Galactose oxidase, central domain; Region: Kelch_3; cl02701 298653018411 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 298653018412 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 298653018413 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 298653018414 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 298653018415 Cu(I) binding site [ion binding]; other site 298653018416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653018417 S-adenosylmethionine binding site [chemical binding]; other site 298653018418 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 298653018419 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 298653018420 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 298653018421 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 298653018422 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 298653018423 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 298653018424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653018425 S-adenosylmethionine binding site [chemical binding]; other site 298653018426 Carboxylesterase family; Region: COesterase; pfam00135 298653018427 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653018428 substrate binding pocket [chemical binding]; other site 298653018429 catalytic triad [active] 298653018430 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 298653018431 DNA binding residues [nucleotide binding] 298653018432 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 298653018433 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 298653018434 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 298653018435 NAD binding site [chemical binding]; other site 298653018436 Phe binding site; other site 298653018437 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 298653018438 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 298653018439 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 298653018440 dimerization interface [polypeptide binding]; other site 298653018441 putative ATP binding site [chemical binding]; other site 298653018442 amidophosphoribosyltransferase; Provisional; Region: PRK07847 298653018443 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 298653018444 active site 298653018445 tetramer interface [polypeptide binding]; other site 298653018446 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 298653018447 active site 298653018448 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 298653018449 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 298653018450 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 298653018451 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 298653018452 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 298653018453 Cupin domain; Region: Cupin_2; cl09118 298653018454 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 298653018455 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 298653018456 DNA binding site [nucleotide binding] 298653018457 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 298653018458 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 298653018459 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 298653018460 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653018461 H+ Antiporter protein; Region: 2A0121; TIGR00900 298653018462 MarR family; Region: MarR; pfam01047 298653018463 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 298653018464 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 298653018465 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653018466 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653018467 active site 298653018468 phosphorylation site [posttranslational modification] 298653018469 intermolecular recognition site; other site 298653018470 dimerization interface [polypeptide binding]; other site 298653018471 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653018472 DNA binding residues [nucleotide binding] 298653018473 dimerization interface [polypeptide binding]; other site 298653018474 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 298653018475 Citrate synthase; Region: Citrate_synt; pfam00285 298653018476 oxalacetate binding site [chemical binding]; other site 298653018477 citrylCoA binding site [chemical binding]; other site 298653018478 coenzyme A binding site [chemical binding]; other site 298653018479 catalytic triad [active] 298653018480 phosphoserine aminotransferase; Provisional; Region: PRK03080 298653018481 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 298653018482 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 298653018483 catalytic residue [active] 298653018484 citrate synthase 2; Provisional; Region: PRK12350 298653018485 Citrate synthase; Region: Citrate_synt; pfam00285 298653018486 oxalacetate binding site [chemical binding]; other site 298653018487 citrylCoA binding site [chemical binding]; other site 298653018488 coenzyme A binding site [chemical binding]; other site 298653018489 catalytic triad [active] 298653018490 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 298653018491 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 298653018492 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 298653018493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 298653018494 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 298653018495 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 298653018496 DNA photolyase; Region: DNA_photolyase; pfam00875 298653018497 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 298653018498 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 298653018499 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 298653018500 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 298653018501 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 298653018502 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 298653018503 protein binding site [polypeptide binding]; other site 298653018504 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 298653018505 CopC domain; Region: CopC; pfam04234 298653018506 Copper resistance protein D; Region: CopD; pfam05425 298653018507 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 298653018508 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 298653018509 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 298653018510 MOSC domain; Region: MOSC; pfam03473 298653018511 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 298653018512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 298653018513 active site 298653018514 phosphorylation site [posttranslational modification] 298653018515 intermolecular recognition site; other site 298653018516 dimerization interface [polypeptide binding]; other site 298653018517 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 298653018518 DNA binding residues [nucleotide binding] 298653018519 tyramine oxidase; Provisional; Region: tynA; PRK11504 298653018520 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 298653018521 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 298653018522 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 298653018523 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 298653018524 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 298653018525 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 298653018526 ligand binding site [chemical binding]; other site 298653018527 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 298653018528 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 298653018529 intersubunit interface [polypeptide binding]; other site 298653018530 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 298653018531 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 298653018532 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 298653018533 dimer interface [polypeptide binding]; other site 298653018534 ABC-ATPase subunit interface; other site 298653018535 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 298653018536 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 298653018537 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 298653018538 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 298653018539 Probable transposase; Region: OrfB_IS605; pfam01385 298653018540 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 298653018541 Transposase IS200 like; Region: Y1_Tnp; pfam01797 298653018542 alanine aminotransferase; Validated; Region: PRK08363 298653018543 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 298653018544 pyridoxal 5'-phosphate binding site [chemical binding]; other site 298653018545 homodimer interface [polypeptide binding]; other site 298653018546 catalytic residue [active] 298653018547 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 298653018548 metal binding site 2 [ion binding]; metal-binding site 298653018549 putative DNA binding helix; other site 298653018550 metal binding site 1 [ion binding]; metal-binding site 298653018551 dimer interface [polypeptide binding]; other site 298653018552 structural Zn2+ binding site [ion binding]; other site 298653018553 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 298653018554 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 298653018555 putative active site [active] 298653018556 putative metal binding site [ion binding]; other site 298653018557 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 298653018558 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 298653018559 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 298653018560 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 298653018561 TPP-binding site [chemical binding]; other site 298653018562 tetramer interface [polypeptide binding]; other site 298653018563 heterodimer interface [polypeptide binding]; other site 298653018564 phosphorylation loop region [posttranslational modification] 298653018565 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 298653018566 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 298653018567 alpha subunit interface [polypeptide binding]; other site 298653018568 TPP binding site [chemical binding]; other site 298653018569 heterodimer interface [polypeptide binding]; other site 298653018570 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 298653018571 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 298653018572 E3 interaction surface; other site 298653018573 lipoyl attachment site [posttranslational modification]; other site 298653018574 e3 binding domain; Region: E3_binding; pfam02817 298653018575 dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843 298653018576 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 298653018577 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 298653018578 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 298653018579 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 298653018580 active site 298653018581 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 298653018582 patatin-related protein; Region: TIGR03607 298653018583 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 298653018584 putative FMN binding site [chemical binding]; other site 298653018585 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 298653018586 MarR family; Region: MarR; pfam01047 298653018587 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 298653018588 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 298653018589 Walker A/P-loop; other site 298653018590 ATP binding site [chemical binding]; other site 298653018591 Q-loop/lid; other site 298653018592 ABC transporter signature motif; other site 298653018593 Walker B; other site 298653018594 D-loop; other site 298653018595 H-loop/switch region; other site 298653018596 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 298653018597 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 298653018598 Double zinc ribbon; Region: DZR; pfam12773 298653018599 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 298653018600 cyclase homology domain; Region: CHD; cd07302 298653018601 nucleotidyl binding site; other site 298653018602 metal binding site [ion binding]; metal-binding site 298653018603 dimer interface [polypeptide binding]; other site 298653018604 Predicted ATPase [General function prediction only]; Region: COG3899 298653018605 AAA ATPase domain; Region: AAA_16; pfam13191 298653018606 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 298653018607 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 298653018608 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 298653018609 chitooligosaccharide synthase NodC; Region: nodulat_NodC; TIGR04242 298653018610 Hyaluronan synthases catalyze polymerization of hyaluronan; Region: GT2_HAS; cd06434 298653018611 DXD motif; other site 298653018612 Right handed beta helix region; Region: Beta_helix; pfam13229 298653018613 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 298653018614 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 298653018615 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 298653018616 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 298653018617 active site 298653018618 dimer interface [polypeptide binding]; other site 298653018619 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 298653018620 dimer interface [polypeptide binding]; other site 298653018621 active site 298653018622 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653018623 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653018624 active site 298653018625 ATP binding site [chemical binding]; other site 298653018626 substrate binding site [chemical binding]; other site 298653018627 activation loop (A-loop); other site 298653018628 NHL repeat; Region: NHL; pfam01436 298653018629 NHL repeat; Region: NHL; pfam01436 298653018630 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 298653018631 Catalytic domain of Protein Kinases; Region: PKc; cd00180 298653018632 active site 298653018633 ATP binding site [chemical binding]; other site 298653018634 substrate binding site [chemical binding]; other site 298653018635 activation loop (A-loop); other site 298653018636 NHL repeat; Region: NHL; pfam01436 298653018637 FAD binding domain; Region: FAD_binding_4; pfam01565 298653018638 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 298653018639 Berberine and berberine like; Region: BBE; pfam08031 298653018640 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 298653018641 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 298653018642 N-acetyl-D-glucosamine binding site [chemical binding]; other site 298653018643 catalytic residue [active] 298653018644 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 298653018645 NlpC/P60 family; Region: NLPC_P60; pfam00877 298653018646 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 298653018647 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 298653018648 AAA-like domain; Region: AAA_10; pfam12846 298653018649 Nuclease-related domain; Region: NERD; pfam08378 298653018650 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 298653018651 TIGR03440 family protein; Region: unchr_TIGR03440 298653018652 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 298653018653 TIGR03442 family protein; Region: TIGR03442 298653018654 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 298653018655 putative active site [active] 298653018656 putative dimer interface [polypeptide binding]; other site 298653018657 probable methyltransferase; Region: TIGR03438 298653018658 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 298653018659 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 298653018660 active site 298653018661 catalytic residues [active] 298653018662 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 298653018663 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 298653018664 replicative DNA helicase; Region: DnaB; TIGR00665 298653018665 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 298653018666 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 298653018667 Walker A motif; other site 298653018668 ATP binding site [chemical binding]; other site 298653018669 Walker B motif; other site 298653018670 DNA binding loops [nucleotide binding] 298653018671 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 298653018672 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 298653018673 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 298653018674 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 298653018675 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 298653018676 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 298653018677 dimer interface [polypeptide binding]; other site 298653018678 ssDNA binding site [nucleotide binding]; other site 298653018679 tetramer (dimer of dimers) interface [polypeptide binding]; other site 298653018680 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 298653018681 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 298653018682 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 298653018683 Transglycosylase; Region: Transgly; pfam00912 298653018684 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 298653018685 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 298653018686 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 298653018687 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 298653018688 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 298653018689 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 298653018690 metal ion-dependent adhesion site (MIDAS); other site 298653018691 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 298653018692 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 298653018693 active site 298653018694 NTP binding site [chemical binding]; other site 298653018695 metal binding triad [ion binding]; metal-binding site 298653018696 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 298653018697 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 298653018698 Zn2+ binding site [ion binding]; other site 298653018699 Mg2+ binding site [ion binding]; other site 298653018700 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 298653018701 nudix motif; other site 298653018702 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 298653018703 integral membrane protein MviN; Region: mviN; TIGR01695 298653018704 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 298653018705 active site 298653018706 ATP binding site [chemical binding]; other site 298653018707 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 298653018708 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 298653018709 DNA binding residues [nucleotide binding] 298653018710 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 298653018711 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 298653018712 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 298653018713 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 298653018714 catalytic residues [active] 298653018715 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 298653018716 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 298653018717 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 298653018718 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 298653018719 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 298653018720 active site 298653018721 ParB-like partition proteins; Region: parB_part; TIGR00180 298653018722 ParB-like nuclease domain; Region: ParBc; pfam02195 298653018723 KorB domain; Region: KorB; pfam08535 298653018724 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 298653018725 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 298653018726 Magnesium ion binding site [ion binding]; other site 298653018727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 298653018728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 298653018729 S-adenosylmethionine binding site [chemical binding]; other site 298653018730 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 298653018731 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 298653018732 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 298653018733 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 298653018734 G-X-X-G motif; other site 298653018735 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 298653018736 RxxxH motif; other site 298653018737 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 298653018738 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 298653018739 hypothetical protein; Provisional; Region: PRK14376 298653018740 Ribonuclease P; Region: Ribonuclease_P; cl00457 298653018741 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399