-- dump date 20140619_095835 -- class Genbank::misc_feature -- table misc_feature_note -- id note 326424000001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326424000002 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 326424000003 Walker A motif; other site 326424000004 ATP binding site [chemical binding]; other site 326424000005 Walker B motif; other site 326424000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 326424000007 arginine finger; other site 326424000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 326424000009 DnaA box-binding interface [nucleotide binding]; other site 326424000010 DNA polymerase III subunit beta; Validated; Region: PRK07761 326424000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 326424000012 putative DNA binding surface [nucleotide binding]; other site 326424000013 dimer interface [polypeptide binding]; other site 326424000014 beta-clamp/clamp loader binding surface; other site 326424000015 beta-clamp/translesion DNA polymerase binding surface; other site 326424000016 recombination protein F; Reviewed; Region: recF; PRK00064 326424000017 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 326424000018 Walker A/P-loop; other site 326424000019 ATP binding site [chemical binding]; other site 326424000020 Q-loop/lid; other site 326424000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424000022 ABC transporter signature motif; other site 326424000023 Walker B; other site 326424000024 D-loop; other site 326424000025 H-loop/switch region; other site 326424000026 Protein of unknown function (DUF721); Region: DUF721; cl02324 326424000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 326424000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424000029 Mg2+ binding site [ion binding]; other site 326424000030 G-X-G motif; other site 326424000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 326424000032 anchoring element; other site 326424000033 dimer interface [polypeptide binding]; other site 326424000034 ATP binding site [chemical binding]; other site 326424000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 326424000036 active site 326424000037 putative metal-binding site [ion binding]; other site 326424000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 326424000039 DNA gyrase subunit A; Validated; Region: PRK05560 326424000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 326424000041 CAP-like domain; other site 326424000042 active site 326424000043 primary dimer interface [polypeptide binding]; other site 326424000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 326424000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 326424000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 326424000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 326424000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 326424000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 326424000050 RDD family; Region: RDD; pfam06271 326424000051 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 326424000052 active site 326424000053 catalytic residues [active] 326424000054 metal binding site [ion binding]; metal-binding site 326424000055 Methyltransferase domain; Region: Methyltransf_24; pfam13578 326424000056 oligosaccharide amylase; Region: oligosac_amyl; TIGR01577 326424000057 Methyltransferase domain; Region: Methyltransf_23; pfam13489 326424000058 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424000059 S-adenosylmethionine binding site [chemical binding]; other site 326424000060 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 326424000061 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326424000062 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 326424000063 Secretory lipase; Region: LIP; pfam03583 326424000064 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 326424000065 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 326424000066 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 326424000067 Nitrogen regulatory protein P-II; Region: P-II; smart00938 326424000068 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 326424000069 substrate binding site [chemical binding]; other site 326424000070 AAA-like domain; Region: AAA_10; pfam12846 326424000071 Helix-turn-helix domain; Region: HTH_17; cl17695 326424000072 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 326424000073 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 326424000074 N-acetyl-D-glucosamine binding site [chemical binding]; other site 326424000075 catalytic residue [active] 326424000076 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 326424000077 NlpC/P60 family; Region: NLPC_P60; pfam00877 326424000078 FAD binding domain; Region: FAD_binding_4; pfam01565 326424000079 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 326424000080 Berberine and berberine like; Region: BBE; pfam08031 326424000081 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424000082 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424000083 active site 326424000084 ATP binding site [chemical binding]; other site 326424000085 substrate binding site [chemical binding]; other site 326424000086 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 326424000087 substrate binding site [chemical binding]; other site 326424000088 activation loop (A-loop); other site 326424000089 activation loop (A-loop); other site 326424000090 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424000091 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424000092 active site 326424000093 ATP binding site [chemical binding]; other site 326424000094 substrate binding site [chemical binding]; other site 326424000095 activation loop (A-loop); other site 326424000096 NHL repeat; Region: NHL; pfam01436 326424000097 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 326424000098 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 326424000099 active site 326424000100 dimer interface [polypeptide binding]; other site 326424000101 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 326424000102 dimer interface [polypeptide binding]; other site 326424000103 active site 326424000104 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 326424000105 anti sigma factor interaction site; other site 326424000106 regulatory phosphorylation site [posttranslational modification]; other site 326424000107 Double zinc ribbon; Region: DZR; pfam12773 326424000108 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 326424000109 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 326424000110 cyclase homology domain; Region: CHD; cd07302 326424000111 nucleotidyl binding site; other site 326424000112 metal binding site [ion binding]; metal-binding site 326424000113 dimer interface [polypeptide binding]; other site 326424000114 AAA ATPase domain; Region: AAA_16; pfam13191 326424000115 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 326424000116 binding surface 326424000117 TPR motif; other site 326424000118 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 326424000119 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424000120 Walker A/P-loop; other site 326424000121 ATP binding site [chemical binding]; other site 326424000122 Q-loop/lid; other site 326424000123 ABC transporter signature motif; other site 326424000124 Walker B; other site 326424000125 D-loop; other site 326424000126 H-loop/switch region; other site 326424000127 Transcriptional regulators [Transcription]; Region: MarR; COG1846 326424000128 MarR family; Region: MarR; pfam01047 326424000129 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 326424000130 FMN binding site [chemical binding]; other site 326424000131 dimer interface [polypeptide binding]; other site 326424000132 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326424000133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424000134 putative substrate translocation pore; other site 326424000135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424000136 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 326424000137 Protein of unknown function (DUF3376); Region: DUF3376; pfam11856 326424000138 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 326424000139 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424000140 active site 326424000141 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 326424000142 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 326424000143 E3 interaction surface; other site 326424000144 lipoyl attachment site [posttranslational modification]; other site 326424000145 e3 binding domain; Region: E3_binding; pfam02817 326424000146 dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843 326424000147 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 326424000148 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 326424000149 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 326424000150 alpha subunit interface [polypeptide binding]; other site 326424000151 TPP binding site [chemical binding]; other site 326424000152 heterodimer interface [polypeptide binding]; other site 326424000153 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 326424000154 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 326424000155 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 326424000156 TPP-binding site [chemical binding]; other site 326424000157 heterodimer interface [polypeptide binding]; other site 326424000158 tetramer interface [polypeptide binding]; other site 326424000159 phosphorylation loop region [posttranslational modification] 326424000160 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 326424000161 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 326424000162 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 326424000163 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 326424000164 putative active site [active] 326424000165 putative metal binding site [ion binding]; other site 326424000166 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 326424000167 metal binding site 2 [ion binding]; metal-binding site 326424000168 putative DNA binding helix; other site 326424000169 metal binding site 1 [ion binding]; metal-binding site 326424000170 dimer interface [polypeptide binding]; other site 326424000171 structural Zn2+ binding site [ion binding]; other site 326424000172 aminotransferase AlaT; Validated; Region: PRK09265 326424000173 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326424000174 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326424000175 homodimer interface [polypeptide binding]; other site 326424000176 catalytic residue [active] 326424000177 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 326424000178 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 326424000179 ABC-ATPase subunit interface; other site 326424000180 dimer interface [polypeptide binding]; other site 326424000181 putative PBP binding regions; other site 326424000182 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 326424000183 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 326424000184 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 326424000185 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 326424000186 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 326424000187 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 326424000188 ligand binding site [chemical binding]; other site 326424000189 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 326424000190 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 326424000191 Domain of unknown function (DUF222); Region: DUF222; pfam02720 326424000192 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 326424000193 active site 326424000194 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424000195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424000196 active site 326424000197 phosphorylation site [posttranslational modification] 326424000198 intermolecular recognition site; other site 326424000199 dimerization interface [polypeptide binding]; other site 326424000200 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326424000201 DNA binding residues [nucleotide binding] 326424000202 dimerization interface [polypeptide binding]; other site 326424000203 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 326424000204 CopC domain; Region: CopC; pfam04234 326424000205 Copper resistance protein D; Region: CopD; cl00563 326424000206 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 326424000207 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 326424000208 protein binding site [polypeptide binding]; other site 326424000209 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 326424000210 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 326424000211 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 326424000212 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 326424000213 DNA photolyase; Region: DNA_photolyase; pfam00875 326424000214 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 326424000215 active site 326424000216 Fe-S cluster binding site [ion binding]; other site 326424000217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 326424000218 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 326424000219 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 326424000220 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 326424000221 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 326424000222 TIR domain; Region: TIR_2; pfam13676 326424000223 citrate synthase 2; Provisional; Region: PRK12350 326424000224 Citrate synthase; Region: Citrate_synt; pfam00285 326424000225 oxalacetate binding site [chemical binding]; other site 326424000226 citrylCoA binding site [chemical binding]; other site 326424000227 coenzyme A binding site [chemical binding]; other site 326424000228 catalytic triad [active] 326424000229 phosphoserine aminotransferase; Provisional; Region: PRK03080 326424000230 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326424000231 catalytic residue [active] 326424000232 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 326424000233 Citrate synthase; Region: Citrate_synt; pfam00285 326424000234 oxalacetate binding site [chemical binding]; other site 326424000235 citrylCoA binding site [chemical binding]; other site 326424000236 coenzyme A binding site [chemical binding]; other site 326424000237 catalytic triad [active] 326424000238 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424000239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424000240 active site 326424000241 phosphorylation site [posttranslational modification] 326424000242 intermolecular recognition site; other site 326424000243 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326424000244 DNA binding residues [nucleotide binding] 326424000245 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 326424000246 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 326424000247 MarR family; Region: MarR; pfam01047 326424000248 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 326424000249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 326424000250 Clp amino terminal domain; Region: Clp_N; pfam02861 326424000251 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 326424000252 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326424000253 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326424000254 DNA binding site [nucleotide binding] 326424000255 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 326424000256 Chitin binding domain; Region: Chitin_bind_3; pfam03067 326424000257 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 326424000258 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 326424000259 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 326424000260 amidophosphoribosyltransferase; Provisional; Region: PRK07847 326424000261 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 326424000262 active site 326424000263 tetramer interface [polypeptide binding]; other site 326424000264 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326424000265 active site 326424000266 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 326424000267 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 326424000268 dimerization interface [polypeptide binding]; other site 326424000269 putative ATP binding site [chemical binding]; other site 326424000270 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 326424000271 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 326424000272 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 326424000273 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 326424000274 NAD binding site [chemical binding]; other site 326424000275 Phe binding site; other site 326424000276 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 326424000277 DNA binding residues [nucleotide binding] 326424000278 Protein of unknown function, DUF488; Region: DUF488; pfam04343 326424000279 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326424000280 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424000281 non-specific DNA binding site [nucleotide binding]; other site 326424000282 salt bridge; other site 326424000283 sequence-specific DNA binding site [nucleotide binding]; other site 326424000284 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 326424000285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424000286 dimer interface [polypeptide binding]; other site 326424000287 conserved gate region; other site 326424000288 putative PBP binding loops; other site 326424000289 ABC-ATPase subunit interface; other site 326424000290 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 326424000291 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424000292 ABC transporter signature motif; other site 326424000293 Walker B; other site 326424000294 D-loop; other site 326424000295 H-loop/switch region; other site 326424000296 Helix-turn-helix domain; Region: HTH_31; pfam13560 326424000297 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 326424000298 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 326424000299 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 326424000300 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 326424000301 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326424000302 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 326424000303 DNA binding residues [nucleotide binding] 326424000304 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 326424000305 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 326424000306 DNA binding site [nucleotide binding] 326424000307 active site 326424000308 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 326424000309 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 326424000310 NADP binding site [chemical binding]; other site 326424000311 substrate binding site [chemical binding]; other site 326424000312 active site 326424000313 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 326424000314 Protein of unknown function DUF72; Region: DUF72; pfam01904 326424000315 HicB family; Region: HicB; pfam05534 326424000316 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 326424000317 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 326424000318 putative active site [active] 326424000319 metal binding site [ion binding]; metal-binding site 326424000320 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_11; cd13126 326424000321 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 326424000322 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 326424000323 intersubunit interface [polypeptide binding]; other site 326424000324 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 326424000325 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 326424000326 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 326424000327 active site 326424000328 catalytic triad [active] 326424000329 dimer interface [polypeptide binding]; other site 326424000330 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 326424000331 Catalytic domain of Arabidopsis thaliana PI-PLC X domain-containing protein At5g67130 and its uncharacterized homologs; Region: PI-PLCc_At5g67130_like; cd08588 326424000332 putative active site [active] 326424000333 catalytic site [active] 326424000334 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 326424000335 putative hydrophobic ligand binding site [chemical binding]; other site 326424000336 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 326424000337 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 326424000338 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 326424000339 substrate binding pocket [chemical binding]; other site 326424000340 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 326424000341 B12 binding site [chemical binding]; other site 326424000342 cobalt ligand [ion binding]; other site 326424000343 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 326424000344 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 326424000345 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 326424000346 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424000347 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424000348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424000349 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326424000350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424000351 Transcriptional regulators [Transcription]; Region: FadR; COG2186 326424000352 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326424000353 DNA-binding site [nucleotide binding]; DNA binding site 326424000354 FCD domain; Region: FCD; pfam07729 326424000355 Transcriptional regulators [Transcription]; Region: FadR; COG2186 326424000356 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326424000357 DNA-binding site [nucleotide binding]; DNA binding site 326424000358 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 326424000359 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 326424000360 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 326424000361 putative NAD(P) binding site [chemical binding]; other site 326424000362 enoyl-CoA hydratase; Provisional; Region: PRK06495 326424000363 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424000364 substrate binding site [chemical binding]; other site 326424000365 oxyanion hole (OAH) forming residues; other site 326424000366 trimer interface [polypeptide binding]; other site 326424000367 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 326424000368 CoenzymeA binding site [chemical binding]; other site 326424000369 subunit interaction site [polypeptide binding]; other site 326424000370 PHB binding site; other site 326424000371 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 326424000372 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 326424000373 active site 326424000374 FMN binding site [chemical binding]; other site 326424000375 substrate binding site [chemical binding]; other site 326424000376 homotetramer interface [polypeptide binding]; other site 326424000377 catalytic residue [active] 326424000378 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 326424000379 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424000380 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424000381 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 326424000382 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 326424000383 acyl-activating enzyme (AAE) consensus motif; other site 326424000384 putative AMP binding site [chemical binding]; other site 326424000385 putative active site [active] 326424000386 putative CoA binding site [chemical binding]; other site 326424000387 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 326424000388 active site 326424000389 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 326424000390 DUF35 OB-fold domain; Region: DUF35; pfam01796 326424000391 short chain dehydrogenase; Provisional; Region: PRK08251 326424000392 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424000393 NAD(P) binding site [chemical binding]; other site 326424000394 active site 326424000395 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 326424000396 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424000397 substrate binding site [chemical binding]; other site 326424000398 oxyanion hole (OAH) forming residues; other site 326424000399 trimer interface [polypeptide binding]; other site 326424000400 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 326424000401 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424000402 NAD(P) binding site [chemical binding]; other site 326424000403 active site 326424000404 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 326424000405 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424000406 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424000407 active site 326424000408 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424000409 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424000410 active site 326424000411 AAA ATPase domain; Region: AAA_16; pfam13191 326424000412 Predicted ATPase [General function prediction only]; Region: COG3903 326424000413 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424000414 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326424000415 DNA binding residues [nucleotide binding] 326424000416 dimerization interface [polypeptide binding]; other site 326424000417 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 326424000418 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 326424000419 NAD binding site [chemical binding]; other site 326424000420 catalytic Zn binding site [ion binding]; other site 326424000421 substrate binding site [chemical binding]; other site 326424000422 structural Zn binding site [ion binding]; other site 326424000423 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 326424000424 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 326424000425 NAD(P) binding site [chemical binding]; other site 326424000426 catalytic residues [active] 326424000427 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 326424000428 Cytochrome P450; Region: p450; cl12078 326424000429 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 326424000430 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 326424000431 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424000432 Walker A/P-loop; other site 326424000433 ATP binding site [chemical binding]; other site 326424000434 Q-loop/lid; other site 326424000435 ABC transporter signature motif; other site 326424000436 Walker B; other site 326424000437 D-loop; other site 326424000438 H-loop/switch region; other site 326424000439 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 326424000440 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 326424000441 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 326424000442 TM-ABC transporter signature motif; other site 326424000443 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 326424000444 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 326424000445 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 326424000446 YcfA-like protein; Region: YcfA; cl00752 326424000447 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 326424000448 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 326424000449 catalytic nucleophile [active] 326424000450 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 326424000451 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 326424000452 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 326424000453 AAA domain; Region: AAA_22; pfam13401 326424000454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326424000455 Walker A motif; other site 326424000456 ATP binding site [chemical binding]; other site 326424000457 Walker B motif; other site 326424000458 arginine finger; other site 326424000459 stage V sporulation protein K; Region: spore_V_K; TIGR02881 326424000460 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326424000461 Walker A motif; other site 326424000462 ATP binding site [chemical binding]; other site 326424000463 Walker B motif; other site 326424000464 arginine finger; other site 326424000465 stage V sporulation protein K; Region: spore_V_K; TIGR02881 326424000466 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326424000467 Walker A motif; other site 326424000468 ATP binding site [chemical binding]; other site 326424000469 Walker B motif; other site 326424000470 arginine finger; other site 326424000471 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 326424000472 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424000473 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 326424000474 H-loop/switch region; other site 326424000475 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 326424000476 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424000477 Walker A/P-loop; other site 326424000478 ATP binding site [chemical binding]; other site 326424000479 Q-loop/lid; other site 326424000480 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 326424000481 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424000482 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 326424000483 active site 326424000484 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 326424000485 non-prolyl cis peptide bond; other site 326424000486 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424000487 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424000488 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 326424000489 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 326424000490 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424000491 HEXXH motif domain; Region: mod_HExxH; TIGR04267 326424000492 NB-ARC domain; Region: NB-ARC; pfam00931 326424000493 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424000494 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424000495 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424000496 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424000497 Tetratricopeptide repeat; Region: TPR_10; pfam13374 326424000498 Tetratricopeptide repeat; Region: TPR_10; pfam13374 326424000499 MoxR-like ATPases [General function prediction only]; Region: COG0714 326424000500 AAA domain; Region: AAA_11; pfam13086 326424000501 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 326424000502 AAA domain; Region: AAA_12; pfam13087 326424000503 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326424000504 ATP binding site [chemical binding]; other site 326424000505 putative Mg++ binding site [ion binding]; other site 326424000506 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326424000507 nucleotide binding region [chemical binding]; other site 326424000508 ATP-binding site [chemical binding]; other site 326424000509 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 326424000510 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 326424000511 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 326424000512 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 326424000513 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424000514 non-specific DNA binding site [nucleotide binding]; other site 326424000515 salt bridge; other site 326424000516 sequence-specific DNA binding site [nucleotide binding]; other site 326424000517 HipA N-terminal domain; Region: Couple_hipA; pfam13657 326424000518 HipA-like N-terminal domain; Region: HipA_N; pfam07805 326424000519 HipA-like C-terminal domain; Region: HipA_C; pfam07804 326424000520 Predicted type IV restriction endonuclease [Defense mechanisms]; Region: COG2810 326424000521 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 326424000522 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 326424000523 ATP-binding site [chemical binding]; other site 326424000524 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 326424000525 Putative catalytic domain of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar4; cd09132 326424000526 PLD-like domain; Region: PLDc_2; pfam13091 326424000527 putative active site [active] 326424000528 putative catalytic site [active] 326424000529 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424000530 S-adenosylmethionine binding site [chemical binding]; other site 326424000531 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424000532 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424000533 active site 326424000534 ATP binding site [chemical binding]; other site 326424000535 substrate binding site [chemical binding]; other site 326424000536 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 326424000537 substrate binding site [chemical binding]; other site 326424000538 activation loop (A-loop); other site 326424000539 activation loop (A-loop); other site 326424000540 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 326424000541 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 326424000542 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 326424000543 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 326424000544 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 326424000545 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424000546 Walker A/P-loop; other site 326424000547 ATP binding site [chemical binding]; other site 326424000548 Q-loop/lid; other site 326424000549 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 326424000550 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424000551 Walker A/P-loop; other site 326424000552 ATP binding site [chemical binding]; other site 326424000553 Q-loop/lid; other site 326424000554 ABC transporter signature motif; other site 326424000555 Walker B; other site 326424000556 D-loop; other site 326424000557 H-loop/switch region; other site 326424000558 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424000559 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 326424000560 active site 326424000561 ATP binding site [chemical binding]; other site 326424000562 substrate binding site [chemical binding]; other site 326424000563 activation loop (A-loop); other site 326424000564 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 326424000565 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 326424000566 putative sugar binding sites [chemical binding]; other site 326424000567 Q-X-W motif; other site 326424000568 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 326424000569 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 326424000570 Survival protein SurE; Region: SurE; pfam01975 326424000571 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 326424000572 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 326424000573 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 326424000574 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 326424000575 active site 326424000576 metal binding site [ion binding]; metal-binding site 326424000577 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 326424000578 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 326424000579 catalytic residues [active] 326424000580 catalytic nucleophile [active] 326424000581 Recombinase; Region: Recombinase; pfam07508 326424000582 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 326424000583 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 326424000584 putative active site [active] 326424000585 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326424000586 DNA-binding site [nucleotide binding]; DNA binding site 326424000587 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 326424000588 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 326424000589 Domain of unknown function (DUF222); Region: DUF222; pfam02720 326424000590 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 326424000591 active site 326424000592 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 326424000593 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 326424000594 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 326424000595 active site 326424000596 dimer interface [polypeptide binding]; other site 326424000597 motif 1; other site 326424000598 motif 2; other site 326424000599 motif 3; other site 326424000600 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 326424000601 anticodon binding site; other site 326424000602 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326424000603 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 326424000604 FeS/SAM binding site; other site 326424000605 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 326424000606 Amidohydrolase; Region: Amidohydro_2; pfam04909 326424000607 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 326424000608 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 326424000609 B12 binding site [chemical binding]; other site 326424000610 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 326424000611 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326424000612 FeS/SAM binding site; other site 326424000613 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 326424000614 hypothetical protein; Provisional; Region: PRK08317 326424000615 Methyltransferase domain; Region: Methyltransf_11; pfam08241 326424000616 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 326424000617 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 326424000618 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 326424000619 dimer interface [polypeptide binding]; other site 326424000620 decamer (pentamer of dimers) interface [polypeptide binding]; other site 326424000621 catalytic triad [active] 326424000622 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 326424000623 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 326424000624 DNA binding site [nucleotide binding] 326424000625 putative catalytic residues [active] 326424000626 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 326424000627 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 326424000628 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424000629 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 326424000630 active site 326424000631 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 326424000632 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 326424000633 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 326424000634 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 326424000635 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 326424000636 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 326424000637 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424000638 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424000639 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 326424000640 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 326424000641 NAD binding site [chemical binding]; other site 326424000642 catalytic residues [active] 326424000643 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 326424000644 classical (c) SDRs; Region: SDR_c; cd05233 326424000645 NAD(P) binding site [chemical binding]; other site 326424000646 active site 326424000647 Domain of unknown function (DUF222); Region: DUF222; pfam02720 326424000648 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 326424000649 active site 326424000650 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 326424000651 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 326424000652 substrate binding pocket [chemical binding]; other site 326424000653 catalytic triad [active] 326424000654 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 326424000655 classical (c) SDRs; Region: SDR_c; cd05233 326424000656 NAD(P) binding site [chemical binding]; other site 326424000657 active site 326424000658 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424000659 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 326424000660 NAD(P) binding site [chemical binding]; other site 326424000661 active site 326424000662 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326424000663 putative DNA binding site [nucleotide binding]; other site 326424000664 dimerization interface [polypeptide binding]; other site 326424000665 putative Zn2+ binding site [ion binding]; other site 326424000666 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 326424000667 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424000668 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 326424000669 Walker A/P-loop; other site 326424000670 ATP binding site [chemical binding]; other site 326424000671 Q-loop/lid; other site 326424000672 ABC transporter signature motif; other site 326424000673 Walker B; other site 326424000674 D-loop; other site 326424000675 H-loop/switch region; other site 326424000676 Amidohydrolase; Region: Amidohydro_2; pfam04909 326424000677 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 326424000678 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 326424000679 TM-ABC transporter signature motif; other site 326424000680 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 326424000681 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 326424000682 TM-ABC transporter signature motif; other site 326424000683 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 326424000684 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 326424000685 Walker A/P-loop; other site 326424000686 ATP binding site [chemical binding]; other site 326424000687 Q-loop/lid; other site 326424000688 ABC transporter signature motif; other site 326424000689 Walker B; other site 326424000690 D-loop; other site 326424000691 H-loop/switch region; other site 326424000692 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 326424000693 Amidase; Region: Amidase; cl11426 326424000694 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424000695 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 326424000696 AAA ATPase domain; Region: AAA_16; pfam13191 326424000697 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424000698 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326424000699 DNA binding residues [nucleotide binding] 326424000700 dimerization interface [polypeptide binding]; other site 326424000701 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 326424000702 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326424000703 Walker A/P-loop; other site 326424000704 ATP binding site [chemical binding]; other site 326424000705 Q-loop/lid; other site 326424000706 ABC transporter signature motif; other site 326424000707 Walker B; other site 326424000708 D-loop; other site 326424000709 H-loop/switch region; other site 326424000710 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 326424000711 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 326424000712 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326424000713 Walker A/P-loop; other site 326424000714 ATP binding site [chemical binding]; other site 326424000715 Q-loop/lid; other site 326424000716 ABC transporter signature motif; other site 326424000717 Walker B; other site 326424000718 D-loop; other site 326424000719 H-loop/switch region; other site 326424000720 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 326424000721 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 326424000722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424000723 putative PBP binding loops; other site 326424000724 ABC-ATPase subunit interface; other site 326424000725 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 326424000726 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 326424000727 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 326424000728 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 326424000729 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 326424000730 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424000731 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424000732 SnoaL-like domain; Region: SnoaL_4; pfam13577 326424000733 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 326424000734 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 326424000735 classical (c) SDRs; Region: SDR_c; cd05233 326424000736 NAD(P) binding site [chemical binding]; other site 326424000737 active site 326424000738 Erythronolide synthase docking; Region: Docking; pfam08990 326424000739 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326424000740 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326424000741 active site 326424000742 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 326424000743 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 326424000744 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326424000745 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 326424000746 putative NADP binding site [chemical binding]; other site 326424000747 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326424000748 active site 326424000749 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326424000750 Thioesterase; Region: PKS_TE; smart00824 326424000751 Erythronolide synthase docking; Region: Docking; pfam08990 326424000752 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326424000753 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326424000754 active site 326424000755 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 326424000756 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 326424000757 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326424000758 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 326424000759 putative NADP binding site [chemical binding]; other site 326424000760 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326424000761 active site 326424000762 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326424000763 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326424000764 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326424000765 active site 326424000766 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 326424000767 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 326424000768 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326424000769 Erythronolide synthase docking; Region: Docking; pfam08990 326424000770 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 326424000771 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326424000772 active site 326424000773 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 326424000774 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326424000775 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424000776 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 326424000777 putative NADP binding site [chemical binding]; other site 326424000778 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326424000779 active site 326424000780 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326424000781 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326424000782 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326424000783 active site 326424000784 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 326424000785 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 326424000786 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 326424000787 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326424000788 NADP binding site [chemical binding]; other site 326424000789 active site 326424000790 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326424000791 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326424000792 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326424000793 active site 326424000794 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 326424000795 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 326424000796 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326424000797 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 326424000798 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326424000799 active site 326424000800 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 326424000801 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326424000802 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424000803 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 326424000804 Enoylreductase; Region: PKS_ER; smart00829 326424000805 NAD(P) binding site [chemical binding]; other site 326424000806 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 326424000807 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326424000808 putative NADP binding site [chemical binding]; other site 326424000809 active site 326424000810 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326424000811 Kelch motif; Region: Kelch_1; pfam01344 326424000812 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 326424000813 Kelch motif; Region: Kelch_1; pfam01344 326424000814 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326424000815 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 326424000816 ABC transporter; Region: ABC_tran; pfam00005 326424000817 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424000818 Q-loop/lid; other site 326424000819 ABC transporter signature motif; other site 326424000820 Walker B; other site 326424000821 D-loop; other site 326424000822 H-loop/switch region; other site 326424000823 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424000824 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326424000825 putative substrate translocation pore; other site 326424000826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424000827 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 326424000828 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 326424000829 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326424000830 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 326424000831 classical (c) SDRs; Region: SDR_c; cd05233 326424000832 NAD(P) binding site [chemical binding]; other site 326424000833 active site 326424000834 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424000835 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424000836 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 326424000837 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 326424000838 active site 326424000839 non-prolyl cis peptide bond; other site 326424000840 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424000841 TIGR03086 family protein; Region: TIGR03086 326424000842 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 326424000843 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 326424000844 amidase; Provisional; Region: PRK06061 326424000845 Amidase; Region: Amidase; cl11426 326424000846 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 326424000847 Mechanosensitive ion channel; Region: MS_channel; pfam00924 326424000848 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 326424000849 NNMT/PNMT/TEMT family; Region: NNMT_PNMT_TEMT; pfam01234 326424000850 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 326424000851 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326424000852 Coenzyme A binding pocket [chemical binding]; other site 326424000853 Transcriptional regulators [Transcription]; Region: FadR; COG2186 326424000854 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326424000855 DNA-binding site [nucleotide binding]; DNA binding site 326424000856 FCD domain; Region: FCD; pfam07729 326424000857 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 326424000858 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 326424000859 Na binding site [ion binding]; other site 326424000860 putative substrate binding site [chemical binding]; other site 326424000861 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 326424000862 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424000863 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424000864 active site 326424000865 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 326424000866 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424000867 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 326424000868 active site 326424000869 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 326424000870 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326424000871 catalytic residue [active] 326424000872 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 326424000873 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424000874 acyl-activating enzyme (AAE) consensus motif; other site 326424000875 AMP binding site [chemical binding]; other site 326424000876 active site 326424000877 CoA binding site [chemical binding]; other site 326424000878 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 326424000879 CoA-transferase family III; Region: CoA_transf_3; pfam02515 326424000880 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 326424000881 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326424000882 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 326424000883 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326424000884 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 326424000885 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 326424000886 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326424000887 catalytic residue [active] 326424000888 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 326424000889 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 326424000890 Predicted transcriptional regulators [Transcription]; Region: COG1733 326424000891 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 326424000892 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 326424000893 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 326424000894 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424000895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424000896 putative substrate translocation pore; other site 326424000897 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 326424000898 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 326424000899 putative ligand binding site [chemical binding]; other site 326424000900 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 326424000901 nudix motif; other site 326424000902 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326424000903 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 326424000904 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 326424000905 Walker A/P-loop; other site 326424000906 ATP binding site [chemical binding]; other site 326424000907 Q-loop/lid; other site 326424000908 ABC transporter signature motif; other site 326424000909 Walker B; other site 326424000910 D-loop; other site 326424000911 H-loop/switch region; other site 326424000912 enoyl-CoA hydratase; Provisional; Region: PRK06688 326424000913 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424000914 substrate binding site [chemical binding]; other site 326424000915 oxyanion hole (OAH) forming residues; other site 326424000916 trimer interface [polypeptide binding]; other site 326424000917 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 326424000918 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 326424000919 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 326424000920 putative NADH binding site [chemical binding]; other site 326424000921 putative active site [active] 326424000922 nudix motif; other site 326424000923 putative metal binding site [ion binding]; other site 326424000924 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 326424000925 NIPSNAP; Region: NIPSNAP; pfam07978 326424000926 NIPSNAP; Region: NIPSNAP; pfam07978 326424000927 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 326424000928 FMN binding site [chemical binding]; other site 326424000929 dimer interface [polypeptide binding]; other site 326424000930 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424000931 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424000932 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424000933 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 326424000934 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 326424000935 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 326424000936 DUF35 OB-fold domain; Region: DUF35; pfam01796 326424000937 lipid-transfer protein; Provisional; Region: PRK07855 326424000938 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 326424000939 active site 326424000940 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 326424000941 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 326424000942 ATP binding site [chemical binding]; other site 326424000943 Mg++ binding site [ion binding]; other site 326424000944 motif III; other site 326424000945 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326424000946 nucleotide binding region [chemical binding]; other site 326424000947 ATP-binding site [chemical binding]; other site 326424000948 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 326424000949 RNA binding site [nucleotide binding]; other site 326424000950 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424000951 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424000952 active site 326424000953 Protein of unknown function DUF72; Region: DUF72; pfam01904 326424000954 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 326424000955 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 326424000956 iron-sulfur cluster [ion binding]; other site 326424000957 [2Fe-2S] cluster binding site [ion binding]; other site 326424000958 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 326424000959 hydrophobic ligand binding site; other site 326424000960 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 326424000961 nucleoside/Zn binding site; other site 326424000962 dimer interface [polypeptide binding]; other site 326424000963 catalytic motif [active] 326424000964 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 326424000965 MarR family; Region: MarR_2; pfam12802 326424000966 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 326424000967 classical (c) SDRs; Region: SDR_c; cd05233 326424000968 NAD(P) binding site [chemical binding]; other site 326424000969 active site 326424000970 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424000971 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424000972 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 326424000973 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 326424000974 putative NAD(P) binding site [chemical binding]; other site 326424000975 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 326424000976 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424000977 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424000978 active site 326424000979 ATP binding site [chemical binding]; other site 326424000980 substrate binding site [chemical binding]; other site 326424000981 activation loop (A-loop); other site 326424000982 NHL repeat; Region: NHL; pfam01436 326424000983 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424000984 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424000985 active site 326424000986 ATP binding site [chemical binding]; other site 326424000987 substrate binding site [chemical binding]; other site 326424000988 activation loop (A-loop); other site 326424000989 NHL repeat; Region: NHL; pfam01436 326424000990 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424000991 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424000992 active site 326424000993 ATP binding site [chemical binding]; other site 326424000994 substrate binding site [chemical binding]; other site 326424000995 activation loop (A-loop); other site 326424000996 NHL repeat; Region: NHL; pfam01436 326424000997 NHL repeat; Region: NHL; pfam01436 326424000998 NHL repeat; Region: NHL; pfam01436 326424000999 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 326424001000 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326424001001 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 326424001002 DNA binding residues [nucleotide binding] 326424001003 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 326424001004 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424001005 NAD(P) binding site [chemical binding]; other site 326424001006 active site 326424001007 short chain dehydrogenase; Provisional; Region: PRK06197 326424001008 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 326424001009 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 326424001010 molybdopterin cofactor binding site; other site 326424001011 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 326424001012 molybdopterin cofactor binding site; other site 326424001013 ZIP Zinc transporter; Region: Zip; pfam02535 326424001014 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 326424001015 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 326424001016 DNA binding site [nucleotide binding] 326424001017 active site 326424001018 Int/Topo IB signature motif; other site 326424001019 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 326424001020 helicase Cas3; Provisional; Region: PRK09694 326424001021 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 326424001022 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 326424001023 CRISPR-associated protein Cse1 (CRISPR_cse1); Region: CRISPR_Cse1; pfam09481 326424001024 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 326424001025 CT1975-like protein; Region: Cas_CT1975; pfam09344 326424001026 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 326424001027 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693 326424001028 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 326424001029 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 326424001030 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 326424001031 Transposase; Region: DDE_Tnp_ISL3; pfam01610 326424001032 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 326424001033 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 326424001034 Transposase; Region: DDE_Tnp_ISL3; pfam01610 326424001035 TIR domain; Region: TIR_2; pfam13676 326424001036 Tetratricopeptide repeat; Region: TPR_10; pfam13374 326424001037 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424001038 Tetratricopeptide repeat; Region: TPR_10; pfam13374 326424001039 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424001040 Tetratricopeptide repeat; Region: TPR_10; pfam13374 326424001041 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424001042 Tetratricopeptide repeat; Region: TPR_10; pfam13374 326424001043 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424001044 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424001045 Tetratricopeptide repeat; Region: TPR_10; pfam13374 326424001046 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424001047 Tetratricopeptide repeat; Region: TPR_10; pfam13374 326424001048 Tetratricopeptide repeat; Region: TPR_10; pfam13374 326424001049 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424001050 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 326424001051 binding surface 326424001052 TPR motif; other site 326424001053 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424001054 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424001055 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424001056 Tetratricopeptide repeat; Region: TPR_10; cl17452 326424001057 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424001058 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 326424001059 binding surface 326424001060 TPR motif; other site 326424001061 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424001062 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424001063 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424001064 Tetratricopeptide repeat; Region: TPR_10; pfam13374 326424001065 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424001066 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 326424001067 binding surface 326424001068 TPR motif; other site 326424001069 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424001070 Transposase, Mutator family; Region: Transposase_mut; pfam00872 326424001071 Integrase core domain; Region: rve; pfam00665 326424001072 Integrase core domain; Region: rve_3; pfam13683 326424001073 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 326424001074 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 326424001075 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 326424001076 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 326424001077 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 326424001078 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 326424001079 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 326424001080 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 326424001081 G1 box; other site 326424001082 GTP/Mg2+ binding site [chemical binding]; other site 326424001083 G2 box; other site 326424001084 Switch I region; other site 326424001085 G3 box; other site 326424001086 Switch II region; other site 326424001087 G5 box; other site 326424001088 Protein of unknown function (DUF742); Region: DUF742; pfam05331 326424001089 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 326424001090 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326424001091 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424001092 ATP binding site [chemical binding]; other site 326424001093 Mg2+ binding site [ion binding]; other site 326424001094 G-X-G motif; other site 326424001095 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 326424001096 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 326424001097 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 326424001098 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 326424001099 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 326424001100 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 326424001101 RNA binding site [nucleotide binding]; other site 326424001102 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 326424001103 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 326424001104 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 326424001105 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 326424001106 N-acetyl-D-glucosamine binding site [chemical binding]; other site 326424001107 catalytic residue [active] 326424001108 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 326424001109 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 326424001110 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 326424001111 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 326424001112 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 326424001113 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 326424001114 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 326424001115 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 326424001116 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 326424001117 AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192 326424001118 AIR synthase-related protein, MSMEG_0567 C-terminal family; Region: MSMEG_0567_Cter; TIGR04050 326424001119 dimerization interface [polypeptide binding]; other site 326424001120 putative ATP binding site [chemical binding]; other site 326424001121 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 326424001122 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 326424001123 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 326424001124 inhibitor-cofactor binding pocket; inhibition site 326424001125 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326424001126 catalytic residue [active] 326424001127 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 326424001128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424001129 NAD(P) binding site [chemical binding]; other site 326424001130 active site 326424001131 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 326424001132 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 326424001133 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 326424001134 nudix motif; other site 326424001135 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 326424001136 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 326424001137 NADH kinase; Region: PLN02929 326424001138 Domain of unknown function (DUF397); Region: DUF397; pfam04149 326424001139 Helix-turn-helix domain; Region: HTH_31; pfam13560 326424001140 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 326424001141 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 326424001142 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424001143 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424001144 active site 326424001145 phosphorylation site [posttranslational modification] 326424001146 intermolecular recognition site; other site 326424001147 dimerization interface [polypeptide binding]; other site 326424001148 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326424001149 dimerization interface [polypeptide binding]; other site 326424001150 DNA binding residues [nucleotide binding] 326424001151 Histidine kinase; Region: HisKA_3; pfam07730 326424001152 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424001153 ATP binding site [chemical binding]; other site 326424001154 Mg2+ binding site [ion binding]; other site 326424001155 G-X-G motif; other site 326424001156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 326424001157 hypothetical protein; Provisional; Region: PRK07236 326424001158 hypothetical protein; Validated; Region: PRK05868 326424001159 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424001160 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 326424001161 Domain of unknown function (DUF427); Region: DUF427; pfam04248 326424001162 topology modulation protein; Reviewed; Region: PRK08118 326424001163 AAA domain; Region: AAA_17; pfam13207 326424001164 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 326424001165 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 326424001166 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326424001167 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 326424001168 Coenzyme A binding pocket [chemical binding]; other site 326424001169 Transcriptional regulators [Transcription]; Region: MarR; COG1846 326424001170 MarR family; Region: MarR_2; pfam12802 326424001171 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 326424001172 active site 326424001173 metal binding site [ion binding]; metal-binding site 326424001174 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 326424001175 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 326424001176 Predicted transcriptional regulator [Transcription]; Region: COG2378 326424001177 HTH domain; Region: HTH_11; pfam08279 326424001178 WYL domain; Region: WYL; pfam13280 326424001179 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 326424001180 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424001181 NAD(P) binding site [chemical binding]; other site 326424001182 active site 326424001183 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424001184 sequence-specific DNA binding site [nucleotide binding]; other site 326424001185 salt bridge; other site 326424001186 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 326424001187 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 326424001188 metal ion-dependent adhesion site (MIDAS); other site 326424001189 MoxR-like ATPases [General function prediction only]; Region: COG0714 326424001190 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 326424001191 SWIM zinc finger; Region: SWIM; pfam04434 326424001192 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 326424001193 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 326424001194 FAD binding pocket [chemical binding]; other site 326424001195 FAD binding motif [chemical binding]; other site 326424001196 phosphate binding motif [ion binding]; other site 326424001197 beta-alpha-beta structure motif; other site 326424001198 NAD binding pocket [chemical binding]; other site 326424001199 FMN-binding domain; Region: FMN_bind; cl01081 326424001200 ApbE family; Region: ApbE; pfam02424 326424001201 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 326424001202 putative active site [active] 326424001203 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 326424001204 Transcriptional regulators [Transcription]; Region: MarR; COG1846 326424001205 MarR family; Region: MarR_2; cl17246 326424001206 Epoxide hydrolase N terminus; Region: EHN; pfam06441 326424001207 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 326424001208 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 326424001209 Carboxylesterase family; Region: COesterase; pfam00135 326424001210 substrate binding pocket [chemical binding]; other site 326424001211 catalytic triad [active] 326424001212 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 326424001213 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 326424001214 minor groove reading motif; other site 326424001215 helix-hairpin-helix signature motif; other site 326424001216 H+ Antiporter protein; Region: 2A0121; TIGR00900 326424001217 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 326424001218 TIR domain; Region: TIR_2; pfam13676 326424001219 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 326424001220 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 326424001221 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424001222 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424001223 SnoaL-like domain; Region: SnoaL_4; pfam13577 326424001224 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 326424001225 classical (c) SDRs; Region: SDR_c; cd05233 326424001226 NAD(P) binding site [chemical binding]; other site 326424001227 active site 326424001228 Cupin domain; Region: Cupin_2; pfam07883 326424001229 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 326424001230 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 326424001231 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 326424001232 Predicted transcriptional regulators [Transcription]; Region: COG1695 326424001233 Transcriptional regulator PadR-like family; Region: PadR; cl17335 326424001234 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424001235 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424001236 active site 326424001237 ATP binding site [chemical binding]; other site 326424001238 substrate binding site [chemical binding]; other site 326424001239 activation loop (A-loop); other site 326424001240 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 326424001241 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424001242 S-adenosylmethionine binding site [chemical binding]; other site 326424001243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424001244 putative substrate translocation pore; other site 326424001245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424001246 MarR family; Region: MarR; pfam01047 326424001247 Penicillinase repressor; Region: Pencillinase_R; cl17580 326424001248 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424001249 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 326424001250 Walker A/P-loop; other site 326424001251 ATP binding site [chemical binding]; other site 326424001252 Q-loop/lid; other site 326424001253 ABC transporter signature motif; other site 326424001254 Walker B; other site 326424001255 D-loop; other site 326424001256 H-loop/switch region; other site 326424001257 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 326424001258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424001259 dimer interface [polypeptide binding]; other site 326424001260 conserved gate region; other site 326424001261 putative PBP binding loops; other site 326424001262 ABC-ATPase subunit interface; other site 326424001263 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 326424001264 substrate binding pocket [chemical binding]; other site 326424001265 membrane-bound complex binding site; other site 326424001266 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 326424001267 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 326424001268 substrate binding pocket [chemical binding]; other site 326424001269 active site 326424001270 iron coordination sites [ion binding]; other site 326424001271 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 326424001272 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 326424001273 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 326424001274 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 326424001275 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 326424001276 Penicillinase repressor; Region: Pencillinase_R; cl17580 326424001277 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 326424001278 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 326424001279 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 326424001280 CAAX protease self-immunity; Region: Abi; pfam02517 326424001281 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 326424001282 putative active site; other site 326424001283 putative metal binding residues [ion binding]; other site 326424001284 signature motif; other site 326424001285 putative triphosphate binding site [ion binding]; other site 326424001286 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 326424001287 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326424001288 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326424001289 active site 326424001290 catalytic tetrad [active] 326424001291 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 326424001292 DNA-binding site [nucleotide binding]; DNA binding site 326424001293 RNA-binding motif; other site 326424001294 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 326424001295 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 326424001296 aspartate kinase; Reviewed; Region: PRK06635 326424001297 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 326424001298 putative nucleotide binding site [chemical binding]; other site 326424001299 putative catalytic residues [active] 326424001300 putative Mg ion binding site [ion binding]; other site 326424001301 putative aspartate binding site [chemical binding]; other site 326424001302 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 326424001303 putative allosteric regulatory site; other site 326424001304 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 326424001305 putative allosteric regulatory residue; other site 326424001306 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 326424001307 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 326424001308 putative metal binding site [ion binding]; other site 326424001309 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 326424001310 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 326424001311 putative NAD(P) binding site [chemical binding]; other site 326424001312 putative substrate binding site [chemical binding]; other site 326424001313 catalytic Zn binding site [ion binding]; other site 326424001314 structural Zn binding site [ion binding]; other site 326424001315 recombination protein RecR; Reviewed; Region: recR; PRK00076 326424001316 Helix-hairpin-helix motif; Region: HHH; pfam00633 326424001317 RecR protein; Region: RecR; pfam02132 326424001318 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 326424001319 putative active site [active] 326424001320 putative metal-binding site [ion binding]; other site 326424001321 tetramer interface [polypeptide binding]; other site 326424001322 hypothetical protein; Validated; Region: PRK00153 326424001323 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 326424001324 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326424001325 Walker A motif; other site 326424001326 ATP binding site [chemical binding]; other site 326424001327 Walker B motif; other site 326424001328 arginine finger; other site 326424001329 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 326424001330 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 326424001331 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 326424001332 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 326424001333 putative sugar binding sites [chemical binding]; other site 326424001334 Q-X-W motif; other site 326424001335 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 326424001336 Immunity protein Imm1; Region: Imm1; pfam14430 326424001337 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326424001338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424001339 putative substrate translocation pore; other site 326424001340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424001341 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 326424001342 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 326424001343 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424001344 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424001345 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 326424001346 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 326424001347 PGAP1-like protein; Region: PGAP1; pfam07819 326424001348 TAP-like protein; Region: Abhydrolase_4; pfam08386 326424001349 Predicted transcriptional regulators [Transcription]; Region: COG1733 326424001350 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 326424001351 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424001352 NADH(P)-binding; Region: NAD_binding_10; pfam13460 326424001353 active site 326424001354 trehalose synthase; Region: treS_nterm; TIGR02456 326424001355 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 326424001356 active site 326424001357 catalytic site [active] 326424001358 short chain dehydrogenase; Provisional; Region: PRK07109 326424001359 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424001360 NAD(P) binding site [chemical binding]; other site 326424001361 active site 326424001362 Beta-lactamase; Region: Beta-lactamase; pfam00144 326424001363 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 326424001364 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424001365 non-specific DNA binding site [nucleotide binding]; other site 326424001366 salt bridge; other site 326424001367 sequence-specific DNA binding site [nucleotide binding]; other site 326424001368 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 326424001369 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 326424001370 TIR domain; Region: TIR_2; pfam13676 326424001371 AAA ATPase domain; Region: AAA_16; pfam13191 326424001372 FOG: WD40 repeat [General function prediction only]; Region: COG2319 326424001373 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 326424001374 structural tetrad; other site 326424001375 FOG: WD40 repeat [General function prediction only]; Region: COG2319 326424001376 WD40 repeats; Region: WD40; smart00320 326424001377 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 326424001378 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326424001379 catalytic residue [active] 326424001380 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424001381 NADH(P)-binding; Region: NAD_binding_10; pfam13460 326424001382 NAD(P) binding site [chemical binding]; other site 326424001383 active site 326424001384 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 326424001385 nucleoside/Zn binding site; other site 326424001386 dimer interface [polypeptide binding]; other site 326424001387 catalytic motif [active] 326424001388 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 326424001389 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 326424001390 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 326424001391 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 326424001392 catalytic triad [active] 326424001393 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 326424001394 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 326424001395 NlpC/P60 family; Region: NLPC_P60; pfam00877 326424001396 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 326424001397 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 326424001398 oligomer interface [polypeptide binding]; other site 326424001399 metal binding site [ion binding]; metal-binding site 326424001400 metal binding site [ion binding]; metal-binding site 326424001401 putative Cl binding site [ion binding]; other site 326424001402 basic sphincter; other site 326424001403 hydrophobic gate; other site 326424001404 periplasmic entrance; other site 326424001405 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 326424001406 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 326424001407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424001408 active site 326424001409 phosphorylation site [posttranslational modification] 326424001410 intermolecular recognition site; other site 326424001411 dimerization interface [polypeptide binding]; other site 326424001412 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 326424001413 CHASE3 domain; Region: CHASE3; pfam05227 326424001414 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 326424001415 dimerization interface [polypeptide binding]; other site 326424001416 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326424001417 dimer interface [polypeptide binding]; other site 326424001418 phosphorylation site [posttranslational modification] 326424001419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424001420 ATP binding site [chemical binding]; other site 326424001421 Mg2+ binding site [ion binding]; other site 326424001422 G-X-G motif; other site 326424001423 Response regulator receiver domain; Region: Response_reg; pfam00072 326424001424 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424001425 active site 326424001426 phosphorylation site [posttranslational modification] 326424001427 intermolecular recognition site; other site 326424001428 dimerization interface [polypeptide binding]; other site 326424001429 TIGR03085 family protein; Region: TIGR03085 326424001430 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 326424001431 nudix motif; other site 326424001432 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 326424001433 Interferon-induced transmembrane protein; Region: CD225; pfam04505 326424001434 Interferon-induced transmembrane protein; Region: CD225; pfam04505 326424001435 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 326424001436 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 326424001437 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 326424001438 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 326424001439 Moco binding site; other site 326424001440 metal coordination site [ion binding]; other site 326424001441 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 326424001442 HSP70 interaction site [polypeptide binding]; other site 326424001443 Interferon-induced transmembrane protein; Region: CD225; pfam04505 326424001444 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 326424001445 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424001446 Walker A/P-loop; other site 326424001447 ATP binding site [chemical binding]; other site 326424001448 Q-loop/lid; other site 326424001449 ABC transporter signature motif; other site 326424001450 Walker B; other site 326424001451 D-loop; other site 326424001452 H-loop/switch region; other site 326424001453 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424001454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424001455 active site 326424001456 phosphorylation site [posttranslational modification] 326424001457 intermolecular recognition site; other site 326424001458 dimerization interface [polypeptide binding]; other site 326424001459 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326424001460 DNA binding residues [nucleotide binding] 326424001461 dimerization interface [polypeptide binding]; other site 326424001462 Histidine kinase; Region: HisKA_3; pfam07730 326424001463 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 326424001464 Mg2+ binding site [ion binding]; other site 326424001465 thymidylate kinase; Validated; Region: PRK07933 326424001466 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 326424001467 homodimer interface [polypeptide binding]; other site 326424001468 putative substrate binding pocket [chemical binding]; other site 326424001469 diiron center [ion binding]; other site 326424001470 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326424001471 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424001472 active site 326424001473 phosphorylation site [posttranslational modification] 326424001474 intermolecular recognition site; other site 326424001475 dimerization interface [polypeptide binding]; other site 326424001476 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326424001477 DNA binding site [nucleotide binding] 326424001478 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 326424001479 dimerization interface [polypeptide binding]; other site 326424001480 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326424001481 dimer interface [polypeptide binding]; other site 326424001482 phosphorylation site [posttranslational modification] 326424001483 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424001484 ATP binding site [chemical binding]; other site 326424001485 Mg2+ binding site [ion binding]; other site 326424001486 G-X-G motif; other site 326424001487 Predicted transcriptional regulator [Transcription]; Region: COG2378 326424001488 HTH domain; Region: HTH_11; pfam08279 326424001489 WYL domain; Region: WYL; pfam13280 326424001490 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 326424001491 active site 326424001492 Protein of unknown function (DUF664); Region: DUF664; pfam04978 326424001493 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 326424001494 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 326424001495 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 326424001496 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 326424001497 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424001498 pyruvate carboxylase; Reviewed; Region: PRK12999 326424001499 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 326424001500 ATP-grasp domain; Region: ATP-grasp_4; cl17255 326424001501 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 326424001502 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 326424001503 active site 326424001504 catalytic residues [active] 326424001505 metal binding site [ion binding]; metal-binding site 326424001506 homodimer binding site [polypeptide binding]; other site 326424001507 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 326424001508 carboxyltransferase (CT) interaction site; other site 326424001509 biotinylation site [posttranslational modification]; other site 326424001510 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 326424001511 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 326424001512 active site 326424001513 Predicted membrane protein [Function unknown]; Region: COG2246 326424001514 GtrA-like protein; Region: GtrA; pfam04138 326424001515 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 326424001516 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 326424001517 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326424001518 dimerization interface [polypeptide binding]; other site 326424001519 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326424001520 dimer interface [polypeptide binding]; other site 326424001521 phosphorylation site [posttranslational modification] 326424001522 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424001523 ATP binding site [chemical binding]; other site 326424001524 Mg2+ binding site [ion binding]; other site 326424001525 G-X-G motif; other site 326424001526 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326424001527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424001528 active site 326424001529 phosphorylation site [posttranslational modification] 326424001530 intermolecular recognition site; other site 326424001531 dimerization interface [polypeptide binding]; other site 326424001532 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326424001533 DNA binding site [nucleotide binding] 326424001534 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 326424001535 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 326424001536 cofactor binding site; other site 326424001537 DNA binding site [nucleotide binding] 326424001538 substrate interaction site [chemical binding]; other site 326424001539 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 326424001540 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 326424001541 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 326424001542 putative NEF/HSP70 interaction site [polypeptide binding]; other site 326424001543 nucleotide binding site [chemical binding]; other site 326424001544 SBD interface [polypeptide binding]; other site 326424001545 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 326424001546 E3 interaction surface; other site 326424001547 lipoyl attachment site [posttranslational modification]; other site 326424001548 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 326424001549 structural tetrad; other site 326424001550 PQQ-like domain; Region: PQQ_2; pfam13360 326424001551 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424001552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424001553 active site 326424001554 phosphorylation site [posttranslational modification] 326424001555 intermolecular recognition site; other site 326424001556 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 326424001557 DNA binding residues [nucleotide binding] 326424001558 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 326424001559 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 326424001560 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 326424001561 metal ion-dependent adhesion site (MIDAS); other site 326424001562 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 326424001563 Predicted acetyltransferase [General function prediction only]; Region: COG2388 326424001564 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 326424001565 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 326424001566 Predicted membrane protein [Function unknown]; Region: COG2259 326424001567 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 326424001568 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; pfam09587 326424001569 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 326424001570 MarR family; Region: MarR_2; cl17246 326424001571 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 326424001572 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 326424001573 active site 326424001574 metal binding site [ion binding]; metal-binding site 326424001575 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 326424001576 iron-sulfur cluster [ion binding]; other site 326424001577 [2Fe-2S] cluster binding site [ion binding]; other site 326424001578 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 326424001579 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 326424001580 L-asparaginase II; Region: Asparaginase_II; pfam06089 326424001581 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 326424001582 HSP70 interaction site [polypeptide binding]; other site 326424001583 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 326424001584 CoA-transferase family III; Region: CoA_transf_3; pfam02515 326424001585 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 326424001586 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 326424001587 dimerization interface [polypeptide binding]; other site 326424001588 ligand binding site [chemical binding]; other site 326424001589 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 326424001590 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 326424001591 TM-ABC transporter signature motif; other site 326424001592 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 326424001593 TM-ABC transporter signature motif; other site 326424001594 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 326424001595 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 326424001596 Walker A/P-loop; other site 326424001597 ATP binding site [chemical binding]; other site 326424001598 Q-loop/lid; other site 326424001599 ABC transporter signature motif; other site 326424001600 Walker B; other site 326424001601 D-loop; other site 326424001602 H-loop/switch region; other site 326424001603 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 326424001604 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 326424001605 Walker A/P-loop; other site 326424001606 ATP binding site [chemical binding]; other site 326424001607 Q-loop/lid; other site 326424001608 ABC transporter signature motif; other site 326424001609 Walker B; other site 326424001610 D-loop; other site 326424001611 H-loop/switch region; other site 326424001612 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326424001613 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326424001614 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 326424001615 putative dimerization interface [polypeptide binding]; other site 326424001616 FAD binding domain; Region: FAD_binding_4; pfam01565 326424001617 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 326424001618 AMP-binding enzyme; Region: AMP-binding; pfam00501 326424001619 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424001620 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424001621 active site 326424001622 CoA binding site [chemical binding]; other site 326424001623 AMP binding site [chemical binding]; other site 326424001624 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 326424001625 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326424001626 ATP binding site [chemical binding]; other site 326424001627 putative Mg++ binding site [ion binding]; other site 326424001628 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326424001629 nucleotide binding region [chemical binding]; other site 326424001630 ATP-binding site [chemical binding]; other site 326424001631 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 326424001632 classical (c) SDRs; Region: SDR_c; cd05233 326424001633 NAD(P) binding site [chemical binding]; other site 326424001634 active site 326424001635 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 326424001636 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 326424001637 ATP synthase subunit C; Region: ATP-synt_C; cl00466 326424001638 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 326424001639 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 326424001640 active site 326424001641 nucleophile elbow; other site 326424001642 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 326424001643 putative acyl-acceptor binding pocket; other site 326424001644 Domain of unknown function (DUF222); Region: DUF222; pfam02720 326424001645 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 326424001646 active site 326424001647 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 326424001648 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 326424001649 ligand binding site [chemical binding]; other site 326424001650 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424001651 S-adenosylmethionine binding site [chemical binding]; other site 326424001652 Transcriptional regulator [Transcription]; Region: IclR; COG1414 326424001653 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 326424001654 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424001655 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424001656 active site 326424001657 ATP binding site [chemical binding]; other site 326424001658 substrate binding site [chemical binding]; other site 326424001659 activation loop (A-loop); other site 326424001660 Protein kinase domain; Region: Pkinase; pfam00069 326424001661 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424001662 active site 326424001663 ATP binding site [chemical binding]; other site 326424001664 substrate binding site [chemical binding]; other site 326424001665 activation loop (A-loop); other site 326424001666 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 326424001667 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 326424001668 probable F420-dependent oxidoreductase, MSMEG_3544 family; Region: F420_MSMEG_3544; TIGR03854 326424001669 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424001670 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 326424001671 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424001672 NAD(P) binding site [chemical binding]; other site 326424001673 active site 326424001674 glucose-1-dehydrogenase; Provisional; Region: PRK06947 326424001675 classical (c) SDRs; Region: SDR_c; cd05233 326424001676 NAD(P) binding site [chemical binding]; other site 326424001677 active site 326424001678 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 326424001679 active site 326424001680 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 326424001681 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 326424001682 PAS domain S-box; Region: sensory_box; TIGR00229 326424001683 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 326424001684 putative active site [active] 326424001685 heme pocket [chemical binding]; other site 326424001686 PAS domain S-box; Region: sensory_box; TIGR00229 326424001687 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 326424001688 putative active site [active] 326424001689 heme pocket [chemical binding]; other site 326424001690 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326424001691 dimer interface [polypeptide binding]; other site 326424001692 phosphorylation site [posttranslational modification] 326424001693 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424001694 ATP binding site [chemical binding]; other site 326424001695 Mg2+ binding site [ion binding]; other site 326424001696 G-X-G motif; other site 326424001697 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 326424001698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424001699 active site 326424001700 phosphorylation site [posttranslational modification] 326424001701 intermolecular recognition site; other site 326424001702 dimerization interface [polypeptide binding]; other site 326424001703 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424001704 Response regulator receiver domain; Region: Response_reg; pfam00072 326424001705 active site 326424001706 phosphorylation site [posttranslational modification] 326424001707 intermolecular recognition site; other site 326424001708 dimerization interface [polypeptide binding]; other site 326424001709 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 326424001710 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 326424001711 substrate binding site [chemical binding]; other site 326424001712 ATP binding site [chemical binding]; other site 326424001713 PAS domain S-box; Region: sensory_box; TIGR00229 326424001714 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 326424001715 putative active site [active] 326424001716 heme pocket [chemical binding]; other site 326424001717 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 326424001718 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 326424001719 metal binding site [ion binding]; metal-binding site 326424001720 active site 326424001721 I-site; other site 326424001722 PAS fold; Region: PAS; pfam00989 326424001723 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 326424001724 putative active site [active] 326424001725 heme pocket [chemical binding]; other site 326424001726 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 326424001727 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 326424001728 metal binding site [ion binding]; metal-binding site 326424001729 active site 326424001730 I-site; other site 326424001731 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 326424001732 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424001733 active site 326424001734 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 326424001735 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 326424001736 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3011794; Product type e : enzyme 326424001737 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 326424001738 Evidence 5 : No homology to any previously reported sequences 326424001739 cystathionine gamma-synthase; Provisional; Region: PRK07811 326424001740 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 326424001741 homodimer interface [polypeptide binding]; other site 326424001742 substrate-cofactor binding pocket; other site 326424001743 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326424001744 catalytic residue [active] 326424001745 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 326424001746 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 326424001747 dimer interface [polypeptide binding]; other site 326424001748 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326424001749 catalytic residue [active] 326424001750 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 326424001751 hypothetical protein; Provisional; Region: PRK11770 326424001752 Domain of unknown function (DUF307); Region: DUF307; pfam03733 326424001753 Domain of unknown function (DUF307); Region: DUF307; pfam03733 326424001754 Ferritin-like domain; Region: Ferritin; pfam00210 326424001755 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 326424001756 dinuclear metal binding motif [ion binding]; other site 326424001757 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 326424001758 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326424001759 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424001760 Walker A/P-loop; other site 326424001761 ATP binding site [chemical binding]; other site 326424001762 Q-loop/lid; other site 326424001763 ABC transporter signature motif; other site 326424001764 Walker B; other site 326424001765 D-loop; other site 326424001766 H-loop/switch region; other site 326424001767 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 326424001768 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326424001769 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 326424001770 Walker A/P-loop; other site 326424001771 ATP binding site [chemical binding]; other site 326424001772 Q-loop/lid; other site 326424001773 ABC transporter signature motif; other site 326424001774 Walker B; other site 326424001775 D-loop; other site 326424001776 H-loop/switch region; other site 326424001777 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 326424001778 putative hydrophobic ligand binding site [chemical binding]; other site 326424001779 Pro-kumamolisin, activation domain; Region: Pro-kuma_activ; smart00944 326424001780 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 326424001781 active site 326424001782 catalytic triad [active] 326424001783 calcium binding site [ion binding]; other site 326424001784 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 326424001785 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 326424001786 putative ligand binding site [chemical binding]; other site 326424001787 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 326424001788 TM-ABC transporter signature motif; other site 326424001789 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 326424001790 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 326424001791 TM-ABC transporter signature motif; other site 326424001792 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 326424001793 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 326424001794 Walker A/P-loop; other site 326424001795 ATP binding site [chemical binding]; other site 326424001796 Q-loop/lid; other site 326424001797 ABC transporter signature motif; other site 326424001798 Walker B; other site 326424001799 D-loop; other site 326424001800 H-loop/switch region; other site 326424001801 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 326424001802 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424001803 Walker A/P-loop; other site 326424001804 ATP binding site [chemical binding]; other site 326424001805 Q-loop/lid; other site 326424001806 ABC transporter signature motif; other site 326424001807 Walker B; other site 326424001808 D-loop; other site 326424001809 H-loop/switch region; other site 326424001810 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 326424001811 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 326424001812 DXD motif; other site 326424001813 Acyltransferase family; Region: Acyl_transf_3; pfam01757 326424001814 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 326424001815 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 326424001816 ThiC-associated domain; Region: ThiC-associated; pfam13667 326424001817 ThiC family; Region: ThiC; pfam01964 326424001818 TIR domain; Region: TIR_2; pfam13676 326424001819 non-specific DNA binding site [nucleotide binding]; other site 326424001820 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 326424001821 salt bridge; other site 326424001822 sequence-specific DNA binding site [nucleotide binding]; other site 326424001823 AAA domain; Region: AAA_33; pfam13671 326424001824 AAA domain; Region: AAA_17; pfam13207 326424001825 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 326424001826 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 326424001827 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 326424001828 catalytic residues [active] 326424001829 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 326424001830 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326424001831 Walker A motif; other site 326424001832 ATP binding site [chemical binding]; other site 326424001833 Walker B motif; other site 326424001834 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424001835 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424001836 active site 326424001837 phosphorylation site [posttranslational modification] 326424001838 intermolecular recognition site; other site 326424001839 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326424001840 dimerization interface [polypeptide binding]; other site 326424001841 DNA binding residues [nucleotide binding] 326424001842 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 326424001843 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 326424001844 Protein of unknown function, DUF462; Region: DUF462; cl01190 326424001845 PemK-like protein; Region: PemK; pfam02452 326424001846 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 326424001847 Ligand Binding Site [chemical binding]; other site 326424001848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 326424001849 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 326424001850 FHA domain; Region: FHA; pfam00498 326424001851 phosphopeptide binding site; other site 326424001852 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 326424001853 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 326424001854 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326424001855 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 326424001856 Walker A motif; other site 326424001857 ATP binding site [chemical binding]; other site 326424001858 Walker B motif; other site 326424001859 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 326424001860 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 326424001861 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 326424001862 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424001863 active site 326424001864 ATP binding site [chemical binding]; other site 326424001865 substrate binding site [chemical binding]; other site 326424001866 activation loop (A-loop); other site 326424001867 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 326424001868 E3 interaction residues; other site 326424001869 Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; Region: UBCc; cl00154 326424001870 Ub thioester intermediate interaction residues; other site 326424001871 active site cysteine 326424001872 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 326424001873 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 326424001874 ATP binding site [chemical binding]; other site 326424001875 substrate interface [chemical binding]; other site 326424001876 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 326424001877 RES domain; Region: RES; smart00953 326424001878 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 326424001879 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 326424001880 putative sugar binding sites [chemical binding]; other site 326424001881 Q-X-W motif; other site 326424001882 Methyltransferase domain; Region: Methyltransf_23; pfam13489 326424001883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424001884 S-adenosylmethionine binding site [chemical binding]; other site 326424001885 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424001886 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424001887 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 326424001888 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 326424001889 Phosphotransferase enzyme family; Region: APH; pfam01636 326424001890 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 326424001891 active site 326424001892 ATP binding site [chemical binding]; other site 326424001893 substrate binding site [chemical binding]; other site 326424001894 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 326424001895 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424001896 Transcriptional regulators [Transcription]; Region: MarR; COG1846 326424001897 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 326424001898 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 326424001899 ATP-grasp domain; Region: ATP-grasp_4; cl17255 326424001900 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 326424001901 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 326424001902 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 326424001903 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 326424001904 classical (c) SDRs; Region: SDR_c; cd05233 326424001905 NAD(P) binding site [chemical binding]; other site 326424001906 active site 326424001907 enoyl-CoA hydratase; Provisional; Region: PRK06210 326424001908 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424001909 substrate binding site [chemical binding]; other site 326424001910 oxyanion hole (OAH) forming residues; other site 326424001911 trimer interface [polypeptide binding]; other site 326424001912 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 326424001913 RibD C-terminal domain; Region: RibD_C; cl17279 326424001914 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 326424001915 active site 326424001916 metal binding site [ion binding]; metal-binding site 326424001917 homotetramer interface [polypeptide binding]; other site 326424001918 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 326424001919 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 326424001920 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 326424001921 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 326424001922 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 326424001923 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 326424001924 metal binding site [ion binding]; metal-binding site 326424001925 active site 326424001926 I-site; other site 326424001927 Domain of unknown function (DUF305); Region: DUF305; pfam03713 326424001928 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; pfam10012 326424001929 PII uridylyl-transferase; Provisional; Region: PRK03381 326424001930 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 326424001931 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 326424001932 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 326424001933 Nitrogen regulatory protein P-II; Region: P-II; smart00938 326424001934 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 326424001935 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 326424001936 NlpC/P60 family; Region: NLPC_P60; pfam00877 326424001937 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 326424001938 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 326424001939 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 326424001940 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 326424001941 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 326424001942 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 326424001943 Dehydroquinase class II; Region: DHquinase_II; pfam01220 326424001944 active site 326424001945 trimer interface [polypeptide binding]; other site 326424001946 dimer interface [polypeptide binding]; other site 326424001947 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 326424001948 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 326424001949 inhibitor-cofactor binding pocket; inhibition site 326424001950 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326424001951 catalytic residue [active] 326424001952 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 326424001953 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 326424001954 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 326424001955 3-amino-5-hydroxybenoic acid synthesis related protein; Region: AHBA_synth_RP; TIGR01454 326424001956 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326424001957 motif II; other site 326424001958 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 326424001959 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 326424001960 shikimate binding site; other site 326424001961 NAD(P) binding site [chemical binding]; other site 326424001962 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 326424001963 dimer interface [polypeptide binding]; other site 326424001964 active site 326424001965 metal binding site [ion binding]; metal-binding site 326424001966 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 326424001967 MarR family; Region: MarR; pfam01047 326424001968 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 326424001969 active site 326424001970 metal binding site [ion binding]; metal-binding site 326424001971 Cupin domain; Region: Cupin_2; cl17218 326424001972 Pirin-related protein [General function prediction only]; Region: COG1741 326424001973 Pirin; Region: Pirin; pfam02678 326424001974 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 326424001975 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 326424001976 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 326424001977 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 326424001978 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 326424001979 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 326424001980 selenocysteine synthase; Provisional; Region: PRK04311 326424001981 Predicted membrane protein [Function unknown]; Region: COG2119 326424001982 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 326424001983 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 326424001984 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 326424001985 anti sigma factor interaction site; other site 326424001986 regulatory phosphorylation site [posttranslational modification]; other site 326424001987 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 326424001988 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 326424001989 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326424001990 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326424001991 DNA binding site [nucleotide binding] 326424001992 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 326424001993 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 326424001994 MoaE interaction surface [polypeptide binding]; other site 326424001995 MoeB interaction surface [polypeptide binding]; other site 326424001996 thiocarboxylated glycine; other site 326424001997 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 326424001998 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 326424001999 catalytic residues [active] 326424002000 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 326424002001 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 326424002002 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 326424002003 active site residue [active] 326424002004 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 326424002005 active site residue [active] 326424002006 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 326424002007 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 326424002008 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 326424002009 heme-binding site [chemical binding]; other site 326424002010 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 326424002011 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 326424002012 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 326424002013 putative ADP-binding pocket [chemical binding]; other site 326424002014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 326424002015 RNase III inhibitor; Provisional; Region: PRK00431 326424002016 ADP-ribose binding site [chemical binding]; other site 326424002017 Protein of unknown function (DUF1269); Region: DUF1269; pfam06897 326424002018 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326424002019 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326424002020 active site 326424002021 catalytic tetrad [active] 326424002022 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326424002023 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424002024 non-specific DNA binding site [nucleotide binding]; other site 326424002025 salt bridge; other site 326424002026 sequence-specific DNA binding site [nucleotide binding]; other site 326424002027 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 326424002028 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 326424002029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424002030 putative PBP binding loops; other site 326424002031 ABC-ATPase subunit interface; other site 326424002032 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 326424002033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424002034 dimer interface [polypeptide binding]; other site 326424002035 conserved gate region; other site 326424002036 ABC-ATPase subunit interface; other site 326424002037 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 326424002038 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 326424002039 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424002040 Walker A/P-loop; other site 326424002041 ATP binding site [chemical binding]; other site 326424002042 Q-loop/lid; other site 326424002043 ABC transporter signature motif; other site 326424002044 Walker B; other site 326424002045 D-loop; other site 326424002046 H-loop/switch region; other site 326424002047 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 326424002048 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 326424002049 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 326424002050 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 326424002051 catalytic core [active] 326424002052 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 326424002053 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 326424002054 PhoU domain; Region: PhoU; pfam01895 326424002055 PhoU domain; Region: PhoU; pfam01895 326424002056 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 326424002057 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326424002058 dimer interface [polypeptide binding]; other site 326424002059 phosphorylation site [posttranslational modification] 326424002060 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424002061 ATP binding site [chemical binding]; other site 326424002062 Mg2+ binding site [ion binding]; other site 326424002063 G-X-G motif; other site 326424002064 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326424002065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424002066 active site 326424002067 phosphorylation site [posttranslational modification] 326424002068 intermolecular recognition site; other site 326424002069 dimerization interface [polypeptide binding]; other site 326424002070 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326424002071 DNA binding site [nucleotide binding] 326424002072 exopolyphosphatase; Region: exo_poly_only; TIGR03706 326424002073 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 326424002074 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 326424002075 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 326424002076 AP (apurinic/apyrimidinic) site pocket; other site 326424002077 Metal-binding active site; metal-binding site 326424002078 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424002079 S-adenosylmethionine binding site [chemical binding]; other site 326424002080 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 326424002081 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 326424002082 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 326424002083 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 326424002084 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 326424002085 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 326424002086 putative NAD(P) binding site [chemical binding]; other site 326424002087 active site 326424002088 putative substrate binding site [chemical binding]; other site 326424002089 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 326424002090 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 326424002091 putative acyl-acceptor binding pocket; other site 326424002092 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 326424002093 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 326424002094 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326424002095 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 326424002096 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 326424002097 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 326424002098 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 326424002099 CoA binding domain; Region: CoA_binding; pfam02629 326424002100 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 326424002101 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 326424002102 tRNA; other site 326424002103 putative tRNA binding site [nucleotide binding]; other site 326424002104 putative NADP binding site [chemical binding]; other site 326424002105 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 326424002106 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 326424002107 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 326424002108 active site 326424002109 domain interfaces; other site 326424002110 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 326424002111 homodimer interface [polypeptide binding]; other site 326424002112 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 326424002113 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 326424002114 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 326424002115 active site 326424002116 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 326424002117 dimer interface [polypeptide binding]; other site 326424002118 active site 326424002119 Schiff base residues; other site 326424002120 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 326424002121 metal-binding site [ion binding] 326424002122 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 326424002123 metal-binding site [ion binding] 326424002124 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 326424002125 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 326424002126 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 326424002127 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 326424002128 active site 326424002129 HIGH motif; other site 326424002130 KMSKS motif; other site 326424002131 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 326424002132 tRNA binding surface [nucleotide binding]; other site 326424002133 anticodon binding site; other site 326424002134 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 326424002135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424002136 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326424002137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424002138 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 326424002139 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 326424002140 dimer interface [polypeptide binding]; other site 326424002141 active site 326424002142 CoA binding pocket [chemical binding]; other site 326424002143 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 326424002144 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 326424002145 inhibitor-cofactor binding pocket; inhibition site 326424002146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326424002147 catalytic residue [active] 326424002148 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 326424002149 catalytic core [active] 326424002150 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 326424002151 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 326424002152 short chain dehydrogenase; Provisional; Region: PRK06523 326424002153 classical (c) SDRs; Region: SDR_c; cd05233 326424002154 NAD(P) binding site [chemical binding]; other site 326424002155 active site 326424002156 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 326424002157 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 326424002158 catalytic residues [active] 326424002159 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 326424002160 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 326424002161 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 326424002162 ResB-like family; Region: ResB; pfam05140 326424002163 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 326424002164 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 326424002165 prenyltransferase; Reviewed; Region: ubiA; PRK12888 326424002166 UbiA prenyltransferase family; Region: UbiA; pfam01040 326424002167 Flavoprotein; Region: Flavoprotein; pfam02441 326424002168 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 326424002169 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326424002170 FeS/SAM binding site; other site 326424002171 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 326424002172 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424002173 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326424002174 sequence-specific DNA binding site [nucleotide binding]; other site 326424002175 salt bridge; other site 326424002176 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424002177 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424002178 active site 326424002179 phosphorylation site [posttranslational modification] 326424002180 intermolecular recognition site; other site 326424002181 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 326424002182 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 326424002183 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 326424002184 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 326424002185 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 326424002186 Active Sites [active] 326424002187 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 326424002188 active site 326424002189 SAM binding site [chemical binding]; other site 326424002190 homodimer interface [polypeptide binding]; other site 326424002191 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 326424002192 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 326424002193 putative active site [active] 326424002194 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 326424002195 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 326424002196 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326424002197 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424002198 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424002199 active site 326424002200 ATP binding site [chemical binding]; other site 326424002201 substrate binding site [chemical binding]; other site 326424002202 activation loop (A-loop); other site 326424002203 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 326424002204 Multicopper oxidase; Region: Cu-oxidase; pfam00394 326424002205 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 326424002206 adenosine deaminase; Provisional; Region: PRK09358 326424002207 active site 326424002208 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 326424002209 S-adenosylmethionine binding site [chemical binding]; other site 326424002210 ubiquinone/menaquinone biosynthesis methyltransferase; Reviewed; Region: ubiE; PRK00216 326424002211 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 326424002212 Dienelactone hydrolase family; Region: DLH; pfam01738 326424002213 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 326424002214 NADH dehydrogenase subunit A; Validated; Region: PRK07928 326424002215 NADH dehydrogenase subunit B; Validated; Region: PRK06411 326424002216 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 326424002217 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 326424002218 NADH dehydrogenase subunit D; Validated; Region: PRK06075 326424002219 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 326424002220 NADH dehydrogenase subunit E; Validated; Region: PRK07539 326424002221 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 326424002222 putative dimer interface [polypeptide binding]; other site 326424002223 [2Fe-2S] cluster binding site [ion binding]; other site 326424002224 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 326424002225 SLBB domain; Region: SLBB; pfam10531 326424002226 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 326424002227 NADH dehydrogenase subunit G; Validated; Region: PRK07860 326424002228 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 326424002229 catalytic loop [active] 326424002230 iron binding site [ion binding]; other site 326424002231 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 326424002232 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 326424002233 molybdopterin cofactor binding site; other site 326424002234 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 326424002235 molybdopterin cofactor binding site; other site 326424002236 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 326424002237 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 326424002238 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 326424002239 4Fe-4S binding domain; Region: Fer4; pfam00037 326424002240 4Fe-4S binding domain; Region: Fer4; pfam00037 326424002241 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 326424002242 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 326424002243 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 326424002244 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 326424002245 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 326424002246 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 326424002247 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 326424002248 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 326424002249 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 326424002250 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 326424002251 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 326424002252 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 326424002253 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 326424002254 substrate binding pocket [chemical binding]; other site 326424002255 chain length determination region; other site 326424002256 substrate-Mg2+ binding site; other site 326424002257 catalytic residues [active] 326424002258 aspartate-rich region 1; other site 326424002259 active site lid residues [active] 326424002260 aspartate-rich region 2; other site 326424002261 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 326424002262 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 326424002263 TPP-binding site [chemical binding]; other site 326424002264 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 326424002265 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 326424002266 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 326424002267 dimer interface [polypeptide binding]; other site 326424002268 PYR/PP interface [polypeptide binding]; other site 326424002269 TPP binding site [chemical binding]; other site 326424002270 substrate binding site [chemical binding]; other site 326424002271 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 326424002272 heat shock protein HtpX; Provisional; Region: PRK03072 326424002273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 326424002274 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 326424002275 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326424002276 active site 326424002277 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 326424002278 putative active site pocket [active] 326424002279 dimerization interface [polypeptide binding]; other site 326424002280 putative catalytic residue [active] 326424002281 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 326424002282 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 326424002283 active site 326424002284 LGFP repeat; Region: LGFP; pfam08310 326424002285 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 326424002286 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 326424002287 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 326424002288 active site 326424002289 catalytic site [active] 326424002290 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 326424002291 active site 2 [active] 326424002292 active site 1 [active] 326424002293 aspartate aminotransferase; Provisional; Region: PRK05764 326424002294 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326424002295 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326424002296 homodimer interface [polypeptide binding]; other site 326424002297 catalytic residue [active] 326424002298 Evidence 2b : Function of strongly homologous gene; Product type t : transporter 326424002299 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 326424002300 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 326424002301 putative homodimer interface [polypeptide binding]; other site 326424002302 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 326424002303 heterodimer interface [polypeptide binding]; other site 326424002304 homodimer interface [polypeptide binding]; other site 326424002305 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 326424002306 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 326424002307 putative thiostrepton binding site; other site 326424002308 23S rRNA interface [nucleotide binding]; other site 326424002309 L7/L12 interface [polypeptide binding]; other site 326424002310 L25 interface [polypeptide binding]; other site 326424002311 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 326424002312 mRNA/rRNA interface [nucleotide binding]; other site 326424002313 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 326424002314 23S rRNA interface [nucleotide binding]; other site 326424002315 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 326424002316 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 326424002317 core dimer interface [polypeptide binding]; other site 326424002318 peripheral dimer interface [polypeptide binding]; other site 326424002319 L10 interface [polypeptide binding]; other site 326424002320 L11 interface [polypeptide binding]; other site 326424002321 putative EF-Tu interaction site [polypeptide binding]; other site 326424002322 putative EF-G interaction site [polypeptide binding]; other site 326424002323 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 326424002324 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 326424002325 RPB12 interaction site [polypeptide binding]; other site 326424002326 RPB1 interaction site [polypeptide binding]; other site 326424002327 RPB10 interaction site [polypeptide binding]; other site 326424002328 RPB11 interaction site [polypeptide binding]; other site 326424002329 RPB3 interaction site [polypeptide binding]; other site 326424002330 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 326424002331 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 326424002332 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 326424002333 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 326424002334 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 326424002335 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 326424002336 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 326424002337 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 326424002338 G-loop; other site 326424002339 DNA binding site [nucleotide binding] 326424002340 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 326424002341 active site 326424002342 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 326424002343 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 326424002344 active site 326424002345 SUMO-1 interface [polypeptide binding]; other site 326424002346 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 326424002347 S17 interaction site [polypeptide binding]; other site 326424002348 S8 interaction site; other site 326424002349 16S rRNA interaction site [nucleotide binding]; other site 326424002350 streptomycin interaction site [chemical binding]; other site 326424002351 23S rRNA interaction site [nucleotide binding]; other site 326424002352 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 326424002353 30S ribosomal protein S7; Validated; Region: PRK05302 326424002354 elongation factor G; Reviewed; Region: PRK00007 326424002355 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 326424002356 G1 box; other site 326424002357 putative GEF interaction site [polypeptide binding]; other site 326424002358 GTP/Mg2+ binding site [chemical binding]; other site 326424002359 Switch I region; other site 326424002360 G2 box; other site 326424002361 G3 box; other site 326424002362 Switch II region; other site 326424002363 G4 box; other site 326424002364 G5 box; other site 326424002365 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 326424002366 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 326424002367 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 326424002368 elongation factor Tu; Reviewed; Region: PRK00049 326424002369 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 326424002370 G1 box; other site 326424002371 GEF interaction site [polypeptide binding]; other site 326424002372 GTP/Mg2+ binding site [chemical binding]; other site 326424002373 Switch I region; other site 326424002374 G2 box; other site 326424002375 G3 box; other site 326424002376 Switch II region; other site 326424002377 G4 box; other site 326424002378 G5 box; other site 326424002379 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 326424002380 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 326424002381 Antibiotic Binding Site [chemical binding]; other site 326424002382 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 326424002383 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 326424002384 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 326424002385 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 326424002386 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 326424002387 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 326424002388 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 326424002389 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 326424002390 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 326424002391 putative translocon binding site; other site 326424002392 protein-rRNA interface [nucleotide binding]; other site 326424002393 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 326424002394 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 326424002395 G-X-X-G motif; other site 326424002396 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 326424002397 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 326424002398 23S rRNA interface [nucleotide binding]; other site 326424002399 5S rRNA interface [nucleotide binding]; other site 326424002400 putative antibiotic binding site [chemical binding]; other site 326424002401 L25 interface [polypeptide binding]; other site 326424002402 L27 interface [polypeptide binding]; other site 326424002403 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 326424002404 putative translocon interaction site; other site 326424002405 23S rRNA interface [nucleotide binding]; other site 326424002406 signal recognition particle (SRP54) interaction site; other site 326424002407 L23 interface [polypeptide binding]; other site 326424002408 trigger factor interaction site; other site 326424002409 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 326424002410 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 326424002411 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 326424002412 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 326424002413 RNA binding site [nucleotide binding]; other site 326424002414 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 326424002415 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 326424002416 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 326424002417 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 326424002418 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 326424002419 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 326424002420 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 326424002421 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 326424002422 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 326424002423 5S rRNA interface [nucleotide binding]; other site 326424002424 23S rRNA interface [nucleotide binding]; other site 326424002425 L5 interface [polypeptide binding]; other site 326424002426 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 326424002427 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 326424002428 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 326424002429 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 326424002430 23S rRNA binding site [nucleotide binding]; other site 326424002431 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 326424002432 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 326424002433 SecY translocase; Region: SecY; pfam00344 326424002434 adenylate kinase; Reviewed; Region: adk; PRK00279 326424002435 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 326424002436 AMP-binding site [chemical binding]; other site 326424002437 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 326424002438 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 326424002439 active site 326424002440 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 326424002441 rRNA binding site [nucleotide binding]; other site 326424002442 predicted 30S ribosome binding site; other site 326424002443 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 326424002444 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 326424002445 30S ribosomal protein S13; Region: bact_S13; TIGR03631 326424002446 30S ribosomal protein S11; Validated; Region: PRK05309 326424002447 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 326424002448 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 326424002449 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 326424002450 RNA binding surface [nucleotide binding]; other site 326424002451 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 326424002452 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 326424002453 alphaNTD - beta interaction site [polypeptide binding]; other site 326424002454 alphaNTD homodimer interface [polypeptide binding]; other site 326424002455 alphaNTD - beta' interaction site [polypeptide binding]; other site 326424002456 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 326424002457 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 326424002458 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 326424002459 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 326424002460 dimerization interface 3.5A [polypeptide binding]; other site 326424002461 active site 326424002462 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 326424002463 23S rRNA interface [nucleotide binding]; other site 326424002464 L3 interface [polypeptide binding]; other site 326424002465 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 326424002466 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 326424002467 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 326424002468 active site 326424002469 substrate binding site [chemical binding]; other site 326424002470 metal binding site [ion binding]; metal-binding site 326424002471 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 326424002472 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 326424002473 glutaminase active site [active] 326424002474 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 326424002475 dimer interface [polypeptide binding]; other site 326424002476 active site 326424002477 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 326424002478 dimer interface [polypeptide binding]; other site 326424002479 active site 326424002480 SWIM zinc finger; Region: SWIM; pfam04434 326424002481 Predicted transcriptional regulators [Transcription]; Region: COG1695 326424002482 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326424002483 dimerization interface [polypeptide binding]; other site 326424002484 putative DNA binding site [nucleotide binding]; other site 326424002485 putative Zn2+ binding site [ion binding]; other site 326424002486 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 326424002487 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 326424002488 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 326424002489 putative ATP binding site [chemical binding]; other site 326424002490 putative substrate binding site [chemical binding]; other site 326424002491 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 326424002492 alanine racemase; Reviewed; Region: alr; PRK00053 326424002493 dimer interface [polypeptide binding]; other site 326424002494 active site 326424002495 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 326424002496 substrate binding site [chemical binding]; other site 326424002497 catalytic residues [active] 326424002498 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 326424002499 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 326424002500 dimer interface [polypeptide binding]; other site 326424002501 active site 326424002502 glycine-pyridoxal phosphate binding site [chemical binding]; other site 326424002503 folate binding site [chemical binding]; other site 326424002504 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 326424002505 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 326424002506 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 326424002507 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 326424002508 Glycoprotease family; Region: Peptidase_M22; pfam00814 326424002509 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 326424002510 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 326424002511 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 326424002512 MarR family; Region: MarR_2; pfam12802 326424002513 Transcriptional regulators [Transcription]; Region: MarR; COG1846 326424002514 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 326424002515 oligomerisation interface [polypeptide binding]; other site 326424002516 mobile loop; other site 326424002517 roof hairpin; other site 326424002518 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 326424002519 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 326424002520 ring oligomerisation interface [polypeptide binding]; other site 326424002521 ATP/Mg binding site [chemical binding]; other site 326424002522 stacking interactions; other site 326424002523 hinge regions; other site 326424002524 Transcription factor WhiB; Region: Whib; pfam02467 326424002525 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 326424002526 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 326424002527 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 326424002528 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 326424002529 active site 326424002530 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 326424002531 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 326424002532 phosphate binding site [ion binding]; other site 326424002533 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 326424002534 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_4; cd06337 326424002535 putative ligand binding site [chemical binding]; other site 326424002536 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 326424002537 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 326424002538 G1 box; other site 326424002539 GTP/Mg2+ binding site [chemical binding]; other site 326424002540 G2 box; other site 326424002541 Switch I region; other site 326424002542 G3 box; other site 326424002543 Switch II region; other site 326424002544 Protein of unknown function (DUF742); Region: DUF742; pfam05331 326424002545 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 326424002546 Nitrate and nitrite sensing; Region: NIT; pfam08376 326424002547 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326424002548 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424002549 ATP binding site [chemical binding]; other site 326424002550 Mg2+ binding site [ion binding]; other site 326424002551 G-X-G motif; other site 326424002552 GMP synthase; Reviewed; Region: guaA; PRK00074 326424002553 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 326424002554 AMP/PPi binding site [chemical binding]; other site 326424002555 candidate oxyanion hole; other site 326424002556 catalytic triad [active] 326424002557 potential glutamine specificity residues [chemical binding]; other site 326424002558 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 326424002559 ATP Binding subdomain [chemical binding]; other site 326424002560 Ligand Binding sites [chemical binding]; other site 326424002561 Dimerization subdomain; other site 326424002562 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 326424002563 hypothetical protein; Provisional; Region: PRK06815 326424002564 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326424002565 catalytic residue [active] 326424002566 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 326424002567 Part of AAA domain; Region: AAA_19; pfam13245 326424002568 Family description; Region: UvrD_C_2; pfam13538 326424002569 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 326424002570 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 326424002571 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424002572 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424002573 active site 326424002574 ATP binding site [chemical binding]; other site 326424002575 substrate binding site [chemical binding]; other site 326424002576 activation loop (A-loop); other site 326424002577 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 326424002578 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 326424002579 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 326424002580 CoA-ligase; Region: Ligase_CoA; pfam00549 326424002581 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 326424002582 CoA binding domain; Region: CoA_binding; smart00881 326424002583 CoA-ligase; Region: Ligase_CoA; pfam00549 326424002584 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424002585 non-specific DNA binding site [nucleotide binding]; other site 326424002586 salt bridge; other site 326424002587 sequence-specific DNA binding site [nucleotide binding]; other site 326424002588 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 326424002589 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 326424002590 active site 326424002591 substrate binding site [chemical binding]; other site 326424002592 cosubstrate binding site; other site 326424002593 catalytic site [active] 326424002594 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 326424002595 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 326424002596 purine monophosphate binding site [chemical binding]; other site 326424002597 dimer interface [polypeptide binding]; other site 326424002598 putative catalytic residues [active] 326424002599 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 326424002600 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 326424002601 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 326424002602 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 326424002603 phosphopeptide binding site; other site 326424002604 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424002605 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 326424002606 DNA binding residues [nucleotide binding] 326424002607 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 326424002608 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 326424002609 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 326424002610 Beta-lactamase; Region: Beta-lactamase; pfam00144 326424002611 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 326424002612 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 326424002613 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 326424002614 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 326424002615 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 326424002616 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 326424002617 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 326424002618 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 326424002619 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326424002620 Coenzyme A binding pocket [chemical binding]; other site 326424002621 TIR domain; Region: TIR_2; pfam13676 326424002622 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 326424002623 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 326424002624 TPR motif; other site 326424002625 binding surface 326424002626 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 326424002627 binding surface 326424002628 TPR motif; other site 326424002629 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 326424002630 TPR repeat; Region: TPR_11; pfam13414 326424002631 TPR motif; other site 326424002632 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 326424002633 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 326424002634 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326424002635 ATP binding site [chemical binding]; other site 326424002636 putative Mg++ binding site [ion binding]; other site 326424002637 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326424002638 nucleotide binding region [chemical binding]; other site 326424002639 ATP-binding site [chemical binding]; other site 326424002640 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 326424002641 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 326424002642 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 326424002643 L-aspartate oxidase; Provisional; Region: PRK06175 326424002644 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 326424002645 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 326424002646 putative Iron-sulfur protein interface [polypeptide binding]; other site 326424002647 putative proximal heme binding site [chemical binding]; other site 326424002648 putative SdhC-like subunit interface [polypeptide binding]; other site 326424002649 putative distal heme binding site [chemical binding]; other site 326424002650 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 326424002651 putative Iron-sulfur protein interface [polypeptide binding]; other site 326424002652 putative proximal heme binding site [chemical binding]; other site 326424002653 putative SdhD-like interface [polypeptide binding]; other site 326424002654 putative distal heme binding site [chemical binding]; other site 326424002655 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 326424002656 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424002657 active site 326424002658 ATP binding site [chemical binding]; other site 326424002659 substrate binding site [chemical binding]; other site 326424002660 activation loop (A-loop); other site 326424002661 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424002662 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424002663 active site 326424002664 ATP binding site [chemical binding]; other site 326424002665 substrate binding site [chemical binding]; other site 326424002666 activation loop (A-loop); other site 326424002667 PsbP; Region: PsbP; cl03356 326424002668 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 326424002669 active site 326424002670 catalytic motif [active] 326424002671 Zn binding site [ion binding]; other site 326424002672 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 326424002673 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 326424002674 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 326424002675 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 326424002676 adenosine deaminase; Provisional; Region: PRK09358 326424002677 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 326424002678 active site 326424002679 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 326424002680 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 326424002681 intersubunit interface [polypeptide binding]; other site 326424002682 active site 326424002683 catalytic residue [active] 326424002684 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326424002685 active site 326424002686 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 326424002687 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 326424002688 active site 326424002689 substrate binding site [chemical binding]; other site 326424002690 metal binding site [ion binding]; metal-binding site 326424002691 purine nucleoside phosphorylase; Provisional; Region: PRK08202 326424002692 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 326424002693 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 326424002694 dimer interface [polypeptide binding]; other site 326424002695 anticodon binding site; other site 326424002696 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 326424002697 motif 1; other site 326424002698 dimer interface [polypeptide binding]; other site 326424002699 active site 326424002700 motif 2; other site 326424002701 GAD domain; Region: GAD; pfam02938 326424002702 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 326424002703 active site 326424002704 motif 3; other site 326424002705 carboxylate-amine ligase; Provisional; Region: PRK13517 326424002706 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 326424002707 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 326424002708 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 326424002709 metal binding site [ion binding]; metal-binding site 326424002710 putative dimer interface [polypeptide binding]; other site 326424002711 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 326424002712 putative active site pocket [active] 326424002713 dimerization interface [polypeptide binding]; other site 326424002714 AIG2-like family; Region: AIG2_2; pfam13772 326424002715 putative catalytic residue [active] 326424002716 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 326424002717 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 326424002718 NAD binding site [chemical binding]; other site 326424002719 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326424002720 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 326424002721 Domain of unknown function (DUF222); Region: DUF222; pfam02720 326424002722 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 326424002723 active site 326424002724 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 326424002725 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 326424002726 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 326424002727 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 326424002728 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 326424002729 carboxyltransferase (CT) interaction site; other site 326424002730 biotinylation site [posttranslational modification]; other site 326424002731 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 326424002732 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 326424002733 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 326424002734 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 326424002735 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 326424002736 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 326424002737 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 326424002738 Bacterial PH domain; Region: DUF304; pfam03703 326424002739 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424002740 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424002741 Predicted membrane protein [Function unknown]; Region: COG2246 326424002742 GtrA-like protein; Region: GtrA; pfam04138 326424002743 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 326424002744 active site clefts [active] 326424002745 zinc binding site [ion binding]; other site 326424002746 dimer interface [polypeptide binding]; other site 326424002747 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 326424002748 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 326424002749 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 326424002750 TIGR03089 family protein; Region: TIGR03089 326424002751 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 326424002752 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 326424002753 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 326424002754 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 326424002755 substrate binding site; other site 326424002756 metal-binding site 326424002757 Oligomer interface; other site 326424002758 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 326424002759 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 326424002760 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 326424002761 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 326424002762 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 326424002763 NADP binding site [chemical binding]; other site 326424002764 active site 326424002765 putative substrate binding site [chemical binding]; other site 326424002766 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 326424002767 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424002768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424002769 putative substrate translocation pore; other site 326424002770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424002771 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 326424002772 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 326424002773 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326424002774 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326424002775 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 326424002776 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 326424002777 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 326424002778 Probable Catalytic site; other site 326424002779 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 326424002780 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 326424002781 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 326424002782 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 326424002783 Walker A/P-loop; other site 326424002784 ATP binding site [chemical binding]; other site 326424002785 Q-loop/lid; other site 326424002786 ABC transporter signature motif; other site 326424002787 Walker B; other site 326424002788 D-loop; other site 326424002789 H-loop/switch region; other site 326424002790 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 326424002791 ABC-2 type transporter; Region: ABC2_membrane; cl17235 326424002792 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 326424002793 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 326424002794 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 326424002795 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 326424002796 dimer interface [polypeptide binding]; other site 326424002797 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424002798 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424002799 active site 326424002800 ATP binding site [chemical binding]; other site 326424002801 substrate binding site [chemical binding]; other site 326424002802 activation loop (A-loop); other site 326424002803 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 326424002804 FOG: WD40 repeat [General function prediction only]; Region: COG2319 326424002805 structural tetrad; other site 326424002806 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 326424002807 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 326424002808 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 326424002809 trimer interface [polypeptide binding]; other site 326424002810 active site 326424002811 substrate binding site [chemical binding]; other site 326424002812 CoA binding site [chemical binding]; other site 326424002813 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 326424002814 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 326424002815 Ligand binding site; other site 326424002816 Putative Catalytic site; other site 326424002817 DXD motif; other site 326424002818 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 326424002819 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326424002820 Methyltransferase domain; Region: Methyltransf_31; pfam13847 326424002821 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424002822 S-adenosylmethionine binding site [chemical binding]; other site 326424002823 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326424002824 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 326424002825 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 326424002826 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 326424002827 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326424002828 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 326424002829 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 326424002830 Probable Catalytic site; other site 326424002831 metal-binding site 326424002832 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 326424002833 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 326424002834 Substrate binding site; other site 326424002835 Mg++ binding site; other site 326424002836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424002837 ATP binding site [chemical binding]; other site 326424002838 Mg2+ binding site [ion binding]; other site 326424002839 G-X-G motif; other site 326424002840 DNA polymerase III subunit beta; Validated; Region: PRK07761 326424002841 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 326424002842 putative DNA binding surface [nucleotide binding]; other site 326424002843 dimer interface [polypeptide binding]; other site 326424002844 beta-clamp/clamp loader binding surface; other site 326424002845 beta-clamp/translesion DNA polymerase binding surface; other site 326424002846 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 326424002847 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 326424002848 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 326424002849 F420 biosynthesis protein FbiB, C-terminal domain; Region: F420_FbiB_CTERM; TIGR03553 326424002850 dimer interface [polypeptide binding]; other site 326424002851 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 326424002852 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 326424002853 phosphate binding site [ion binding]; other site 326424002854 dimer interface [polypeptide binding]; other site 326424002855 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424002856 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424002857 FO synthase; Reviewed; Region: fbiC; PRK09234 326424002858 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326424002859 FeS/SAM binding site; other site 326424002860 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326424002861 FeS/SAM binding site; other site 326424002862 Transcription factor WhiB; Region: Whib; pfam02467 326424002863 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 326424002864 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 326424002865 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 326424002866 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 326424002867 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 326424002868 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 326424002869 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 326424002870 active site 326424002871 substrate binding site [chemical binding]; other site 326424002872 metal binding site [ion binding]; metal-binding site 326424002873 Trm112p-like protein; Region: Trm112p; cl01066 326424002874 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 326424002875 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 326424002876 dimer interface [polypeptide binding]; other site 326424002877 active site 326424002878 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 326424002879 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 326424002880 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 326424002881 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 326424002882 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 326424002883 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 326424002884 ATP binding site [chemical binding]; other site 326424002885 Mg2+ binding site [ion binding]; other site 326424002886 G-X-G motif; other site 326424002887 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326424002888 dimer interface [polypeptide binding]; other site 326424002889 phosphorylation site [posttranslational modification] 326424002890 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424002891 ATP binding site [chemical binding]; other site 326424002892 Mg2+ binding site [ion binding]; other site 326424002893 G-X-G motif; other site 326424002894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424002895 active site 326424002896 phosphorylation site [posttranslational modification] 326424002897 intermolecular recognition site; other site 326424002898 dimerization interface [polypeptide binding]; other site 326424002899 Response regulator receiver domain; Region: Response_reg; pfam00072 326424002900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424002901 active site 326424002902 phosphorylation site [posttranslational modification] 326424002903 intermolecular recognition site; other site 326424002904 dimerization interface [polypeptide binding]; other site 326424002905 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 326424002906 Transglycosylase; Region: Transgly; pfam00912 326424002907 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 326424002908 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 326424002909 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 326424002910 DNA binding residues [nucleotide binding] 326424002911 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 326424002912 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 326424002913 homotetramer interface [polypeptide binding]; other site 326424002914 ligand binding site [chemical binding]; other site 326424002915 catalytic site [active] 326424002916 NAD binding site [chemical binding]; other site 326424002917 RDD family; Region: RDD; pfam06271 326424002918 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 326424002919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424002920 active site 326424002921 phosphorylation site [posttranslational modification] 326424002922 intermolecular recognition site; other site 326424002923 dimerization interface [polypeptide binding]; other site 326424002924 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 326424002925 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 326424002926 active site 326424002927 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326424002928 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326424002929 active site 326424002930 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 326424002931 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 326424002932 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326424002933 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424002934 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 326424002935 Enoylreductase; Region: PKS_ER; smart00829 326424002936 NAD(P) binding site [chemical binding]; other site 326424002937 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 326424002938 KR domain; Region: KR; pfam08659 326424002939 putative NADP binding site [chemical binding]; other site 326424002940 active site 326424002941 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326424002942 Integral membrane protein DUF95; Region: DUF95; pfam01944 326424002943 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 326424002944 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 326424002945 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 326424002946 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326424002947 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 326424002948 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 326424002949 FMN binding site [chemical binding]; other site 326424002950 active site 326424002951 substrate binding site [chemical binding]; other site 326424002952 catalytic residue [active] 326424002953 Domain of unknown function (DUF385); Region: DUF385; pfam04075 326424002954 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 326424002955 Protein of unknown function DUF58; Region: DUF58; pfam01882 326424002956 MoxR-like ATPases [General function prediction only]; Region: COG0714 326424002957 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326424002958 Walker A motif; other site 326424002959 ATP binding site [chemical binding]; other site 326424002960 Walker B motif; other site 326424002961 arginine finger; other site 326424002962 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 326424002963 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 326424002964 30S subunit binding site; other site 326424002965 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424002966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424002967 active site 326424002968 phosphorylation site [posttranslational modification] 326424002969 intermolecular recognition site; other site 326424002970 dimerization interface [polypeptide binding]; other site 326424002971 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326424002972 DNA binding residues [nucleotide binding] 326424002973 dimerization interface [polypeptide binding]; other site 326424002974 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 326424002975 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 326424002976 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 326424002977 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 326424002978 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 326424002979 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 326424002980 nucleotide binding region [chemical binding]; other site 326424002981 SEC-C motif; Region: SEC-C; pfam02810 326424002982 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 326424002983 Helix-turn-helix domain; Region: HTH_17; pfam12728 326424002984 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 326424002985 AAA domain; Region: AAA_31; pfam13614 326424002986 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326424002987 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424002988 non-specific DNA binding site [nucleotide binding]; other site 326424002989 salt bridge; other site 326424002990 sequence-specific DNA binding site [nucleotide binding]; other site 326424002991 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 326424002992 Uncharacterized conserved protein [Function unknown]; Region: COG3743 326424002993 PAS fold; Region: PAS; pfam00989 326424002994 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 326424002995 putative active site [active] 326424002996 heme pocket [chemical binding]; other site 326424002997 PAS fold; Region: PAS_7; pfam12860 326424002998 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 326424002999 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 326424003000 ATP binding site [chemical binding]; other site 326424003001 Walker A motif; other site 326424003002 hexamer interface [polypeptide binding]; other site 326424003003 Walker B motif; other site 326424003004 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 326424003005 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 326424003006 RDD family; Region: RDD; pfam06271 326424003007 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 326424003008 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326424003009 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 326424003010 DNA binding residues [nucleotide binding] 326424003011 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 326424003012 active site 1 [active] 326424003013 dimer interface [polypeptide binding]; other site 326424003014 hexamer interface [polypeptide binding]; other site 326424003015 active site 2 [active] 326424003016 Phosphotransferase enzyme family; Region: APH; pfam01636 326424003017 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 326424003018 active site 326424003019 substrate binding site [chemical binding]; other site 326424003020 ATP binding site [chemical binding]; other site 326424003021 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 326424003022 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 326424003023 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 326424003024 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 326424003025 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 326424003026 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 326424003027 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 326424003028 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 326424003029 substrate binding pocket [chemical binding]; other site 326424003030 substrate-Mg2+ binding site; other site 326424003031 aspartate-rich region 1; other site 326424003032 aspartate-rich region 2; other site 326424003033 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424003034 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424003035 active site 326424003036 ATP binding site [chemical binding]; other site 326424003037 substrate binding site [chemical binding]; other site 326424003038 activation loop (A-loop); other site 326424003039 NHL repeat; Region: NHL; pfam01436 326424003040 NHL repeat; Region: NHL; pfam01436 326424003041 AAA ATPase domain; Region: AAA_16; pfam13191 326424003042 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 326424003043 structural tetrad; other site 326424003044 FOG: WD40 repeat [General function prediction only]; Region: COG2319 326424003045 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 326424003046 structural tetrad; other site 326424003047 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326424003048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424003049 active site 326424003050 phosphorylation site [posttranslational modification] 326424003051 intermolecular recognition site; other site 326424003052 dimerization interface [polypeptide binding]; other site 326424003053 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326424003054 DNA binding site [nucleotide binding] 326424003055 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326424003056 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 326424003057 dimerization interface [polypeptide binding]; other site 326424003058 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424003059 ATP binding site [chemical binding]; other site 326424003060 Mg2+ binding site [ion binding]; other site 326424003061 G-X-G motif; other site 326424003062 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 326424003063 ABC-2 type transporter; Region: ABC2_membrane; cl17235 326424003064 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424003065 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 326424003066 Walker A/P-loop; other site 326424003067 ATP binding site [chemical binding]; other site 326424003068 Q-loop/lid; other site 326424003069 ABC transporter signature motif; other site 326424003070 Walker B; other site 326424003071 D-loop; other site 326424003072 H-loop/switch region; other site 326424003073 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424003074 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 326424003075 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424003076 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 326424003077 active site 326424003078 ATP binding site [chemical binding]; other site 326424003079 substrate binding site [chemical binding]; other site 326424003080 activation loop (A-loop); other site 326424003081 peptide chain release factor 2; Validated; Region: prfB; PRK00578 326424003082 This domain is found in peptide chain release factors; Region: PCRF; smart00937 326424003083 RF-1 domain; Region: RF-1; pfam00472 326424003084 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 326424003085 putative active site [active] 326424003086 putative metal binding site [ion binding]; other site 326424003087 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 326424003088 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 326424003089 active site 326424003090 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326424003091 DNA binding site [nucleotide binding] 326424003092 nitrite reductase subunit NirD; Provisional; Region: PRK14989 326424003093 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326424003094 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 326424003095 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 326424003096 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 326424003097 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 326424003098 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 326424003099 active site 326424003100 SAM binding site [chemical binding]; other site 326424003101 homodimer interface [polypeptide binding]; other site 326424003102 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 326424003103 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 326424003104 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 326424003105 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 326424003106 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424003107 Walker A/P-loop; other site 326424003108 ATP binding site [chemical binding]; other site 326424003109 Q-loop/lid; other site 326424003110 ABC transporter signature motif; other site 326424003111 Walker B; other site 326424003112 D-loop; other site 326424003113 H-loop/switch region; other site 326424003114 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 326424003115 FtsX-like permease family; Region: FtsX; pfam02687 326424003116 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 326424003117 SmpB-tmRNA interface; other site 326424003118 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424003119 S-adenosylmethionine binding site [chemical binding]; other site 326424003120 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 326424003121 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 326424003122 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326424003123 active site 326424003124 metal binding site [ion binding]; metal-binding site 326424003125 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 326424003126 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 326424003127 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 326424003128 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 326424003129 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 326424003130 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 326424003131 active site 326424003132 NTP binding site [chemical binding]; other site 326424003133 metal binding triad [ion binding]; metal-binding site 326424003134 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 326424003135 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 326424003136 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 326424003137 classical (c) SDRs; Region: SDR_c; cd05233 326424003138 NAD(P) binding site [chemical binding]; other site 326424003139 active site 326424003140 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 326424003141 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 326424003142 NAD binding site [chemical binding]; other site 326424003143 catalytic residues [active] 326424003144 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 326424003145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424003146 active site 326424003147 phosphorylation site [posttranslational modification] 326424003148 intermolecular recognition site; other site 326424003149 dimerization interface [polypeptide binding]; other site 326424003150 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 326424003151 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 326424003152 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 326424003153 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 326424003154 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424003155 S-adenosylmethionine binding site [chemical binding]; other site 326424003156 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326424003157 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326424003158 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 326424003159 putative dimerization interface [polypeptide binding]; other site 326424003160 putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/unknown domain fusion protein; Provisional; Region: PRK14495 326424003161 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 326424003162 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 326424003163 nudix motif; other site 326424003164 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 326424003165 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 326424003166 Imelysin; Region: Peptidase_M75; pfam09375 326424003167 Iron permease FTR1 family; Region: FTR1; cl00475 326424003168 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 326424003169 nudix motif; other site 326424003170 Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229 326424003171 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326424003172 motif II; other site 326424003173 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 326424003174 Cupin domain; Region: Cupin_2; cl17218 326424003175 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 326424003176 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 326424003177 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 326424003178 Zn2+ binding site [ion binding]; other site 326424003179 intersubunit interface [polypeptide binding]; other site 326424003180 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 326424003181 amphipathic channel; other site 326424003182 Asn-Pro-Ala signature motifs; other site 326424003183 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 326424003184 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326424003185 DNA-binding site [nucleotide binding]; DNA binding site 326424003186 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326424003187 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326424003188 homodimer interface [polypeptide binding]; other site 326424003189 catalytic residue [active] 326424003190 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 326424003191 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 326424003192 active site 326424003193 catalytic triad [active] 326424003194 dimer interface [polypeptide binding]; other site 326424003195 phenylhydantoinase; Validated; Region: PRK08323 326424003196 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 326424003197 tetramer interface [polypeptide binding]; other site 326424003198 active site 326424003199 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 326424003200 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 326424003201 tetrameric interface [polypeptide binding]; other site 326424003202 NAD binding site [chemical binding]; other site 326424003203 catalytic residues [active] 326424003204 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 326424003205 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 326424003206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424003207 dimer interface [polypeptide binding]; other site 326424003208 conserved gate region; other site 326424003209 putative PBP binding loops; other site 326424003210 ABC-ATPase subunit interface; other site 326424003211 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 326424003212 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 326424003213 Walker A/P-loop; other site 326424003214 ATP binding site [chemical binding]; other site 326424003215 Q-loop/lid; other site 326424003216 ABC transporter signature motif; other site 326424003217 Walker B; other site 326424003218 D-loop; other site 326424003219 H-loop/switch region; other site 326424003220 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 326424003221 NMT1/THI5 like; Region: NMT1; pfam09084 326424003222 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 326424003223 hypothetical protein; Provisional; Region: PRK06062 326424003224 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 326424003225 inhibitor-cofactor binding pocket; inhibition site 326424003226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326424003227 catalytic residue [active] 326424003228 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 326424003229 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424003230 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424003231 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424003232 NAD(P) binding site [chemical binding]; other site 326424003233 active site 326424003234 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 326424003235 active site lid residues [active] 326424003236 substrate binding pocket [chemical binding]; other site 326424003237 catalytic residues [active] 326424003238 substrate-Mg2+ binding site; other site 326424003239 aspartate-rich region 1; other site 326424003240 aspartate-rich region 2; other site 326424003241 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 326424003242 active site lid residues [active] 326424003243 substrate binding pocket [chemical binding]; other site 326424003244 catalytic residues [active] 326424003245 substrate-Mg2+ binding site; other site 326424003246 aspartate-rich region 1; other site 326424003247 aspartate-rich region 2; other site 326424003248 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 326424003249 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 326424003250 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 326424003251 substrate binding pocket [chemical binding]; other site 326424003252 chain length determination region; other site 326424003253 substrate-Mg2+ binding site; other site 326424003254 catalytic residues [active] 326424003255 aspartate-rich region 1; other site 326424003256 active site lid residues [active] 326424003257 aspartate-rich region 2; other site 326424003258 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 326424003259 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 326424003260 Active site cavity [active] 326424003261 catalytic acid [active] 326424003262 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 326424003263 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 326424003264 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 326424003265 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 326424003266 CoenzymeA binding site [chemical binding]; other site 326424003267 subunit interaction site [polypeptide binding]; other site 326424003268 PHB binding site; other site 326424003269 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 326424003270 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326424003271 FeS/SAM binding site; other site 326424003272 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 326424003273 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424003274 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424003275 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 326424003276 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 326424003277 active site 326424003278 UreD urease accessory protein; Region: UreD; cl00530 326424003279 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424003280 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326424003281 sequence-specific DNA binding site [nucleotide binding]; other site 326424003282 salt bridge; other site 326424003283 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 326424003284 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 326424003285 urease subunit alpha; Reviewed; Region: ureC; PRK13206 326424003286 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 326424003287 subunit interactions [polypeptide binding]; other site 326424003288 active site 326424003289 flap region; other site 326424003290 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 326424003291 gamma-beta subunit interface [polypeptide binding]; other site 326424003292 alpha-beta subunit interface [polypeptide binding]; other site 326424003293 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 326424003294 alpha-gamma subunit interface [polypeptide binding]; other site 326424003295 beta-gamma subunit interface [polypeptide binding]; other site 326424003296 NMT1/THI5 like; Region: NMT1; pfam09084 326424003297 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 326424003298 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 326424003299 Walker A/P-loop; other site 326424003300 ATP binding site [chemical binding]; other site 326424003301 Q-loop/lid; other site 326424003302 ABC transporter signature motif; other site 326424003303 Walker B; other site 326424003304 D-loop; other site 326424003305 H-loop/switch region; other site 326424003306 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 326424003307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424003308 dimer interface [polypeptide binding]; other site 326424003309 conserved gate region; other site 326424003310 putative PBP binding loops; other site 326424003311 ABC-ATPase subunit interface; other site 326424003312 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 326424003313 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 326424003314 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 326424003315 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 326424003316 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 326424003317 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 326424003318 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 326424003319 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 326424003320 [2Fe-2S] cluster binding site [ion binding]; other site 326424003321 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 326424003322 hydrophobic ligand binding site; other site 326424003323 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 326424003324 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 326424003325 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 326424003326 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 326424003327 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 326424003328 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 326424003329 allantoinase; Region: allantoinase; TIGR03178 326424003330 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 326424003331 active site 326424003332 putative bifunctional allantoicase/OHCU decarboxylase; Provisional; Region: PRK13797 326424003333 Allantoicase repeat; Region: Allantoicase; pfam03561 326424003334 Allantoicase repeat; Region: Allantoicase; pfam03561 326424003335 OHCU decarboxylase; Region: UraD_2; TIGR03180 326424003336 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 326424003337 active site 326424003338 homotetramer interface [polypeptide binding]; other site 326424003339 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 326424003340 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 326424003341 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 326424003342 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424003343 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 326424003344 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 326424003345 putative dimer interface [polypeptide binding]; other site 326424003346 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326424003347 4Fe-4S binding domain; Region: Fer4; pfam00037 326424003348 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 326424003349 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 326424003350 Amidohydrolase; Region: Amidohydro_4; pfam13147 326424003351 active site 326424003352 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326424003353 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326424003354 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 326424003355 dimerization interface [polypeptide binding]; other site 326424003356 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 326424003357 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 326424003358 dinuclear metal binding motif [ion binding]; other site 326424003359 adenosine deaminase; Provisional; Region: PRK09358 326424003360 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 326424003361 active site 326424003362 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 326424003363 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 326424003364 active site 326424003365 putative substrate binding pocket [chemical binding]; other site 326424003366 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 326424003367 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 326424003368 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 326424003369 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 326424003370 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 326424003371 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 326424003372 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 326424003373 putative ligand binding site [chemical binding]; other site 326424003374 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 326424003375 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 326424003376 Walker A/P-loop; other site 326424003377 ATP binding site [chemical binding]; other site 326424003378 Q-loop/lid; other site 326424003379 ABC transporter signature motif; other site 326424003380 Walker B; other site 326424003381 D-loop; other site 326424003382 H-loop/switch region; other site 326424003383 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 326424003384 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 326424003385 Walker A/P-loop; other site 326424003386 ATP binding site [chemical binding]; other site 326424003387 Q-loop/lid; other site 326424003388 ABC transporter signature motif; other site 326424003389 Walker B; other site 326424003390 D-loop; other site 326424003391 H-loop/switch region; other site 326424003392 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 326424003393 TM-ABC transporter signature motif; other site 326424003394 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 326424003395 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 326424003396 TM-ABC transporter signature motif; other site 326424003397 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 326424003398 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424003399 NAD(P) binding site [chemical binding]; other site 326424003400 active site 326424003401 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326424003402 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424003403 non-specific DNA binding site [nucleotide binding]; other site 326424003404 salt bridge; other site 326424003405 sequence-specific DNA binding site [nucleotide binding]; other site 326424003406 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 326424003407 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 326424003408 active site 326424003409 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 326424003410 nudix motif; other site 326424003411 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 326424003412 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 326424003413 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 326424003414 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 326424003415 MPN+ (JAMM) motif; other site 326424003416 Zinc-binding site [ion binding]; other site 326424003417 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 326424003418 MoaE interaction surface [polypeptide binding]; other site 326424003419 MoeB interaction surface [polypeptide binding]; other site 326424003420 thiocarboxylated glycine; other site 326424003421 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 326424003422 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 326424003423 dimer interface [polypeptide binding]; other site 326424003424 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326424003425 catalytic residue [active] 326424003426 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 326424003427 active site 326424003428 dimerization interface [polypeptide binding]; other site 326424003429 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 326424003430 ribonuclease PH; Reviewed; Region: rph; PRK00173 326424003431 oligomer interface [polypeptide binding]; other site 326424003432 RNA binding site [nucleotide binding]; other site 326424003433 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 326424003434 glutamate racemase; Provisional; Region: PRK00865 326424003435 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 326424003436 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 326424003437 Uncharacterized conserved protein [Function unknown]; Region: COG1359 326424003438 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 326424003439 nudix motif; other site 326424003440 Predicted transcriptional regulators [Transcription]; Region: COG1733 326424003441 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 326424003442 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 326424003443 Cytochrome P450; Region: p450; cl12078 326424003444 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 326424003445 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 326424003446 DNA binding residues [nucleotide binding] 326424003447 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326424003448 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 326424003449 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 326424003450 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 326424003451 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 326424003452 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 326424003453 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 326424003454 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 326424003455 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 326424003456 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 326424003457 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 326424003458 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 326424003459 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 326424003460 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 326424003461 catalytic triad [active] 326424003462 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 326424003463 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 326424003464 catalytic residues [active] 326424003465 Methylamine utilisation protein MauE; Region: MauE; pfam07291 326424003466 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 326424003467 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 326424003468 Cu(I) binding site [ion binding]; other site 326424003469 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 326424003470 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 326424003471 catalytic core [active] 326424003472 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 326424003473 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 326424003474 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 326424003475 oligomerisation interface [polypeptide binding]; other site 326424003476 mobile loop; other site 326424003477 roof hairpin; other site 326424003478 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 326424003479 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424003480 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326424003481 DNA binding residues [nucleotide binding] 326424003482 dimerization interface [polypeptide binding]; other site 326424003483 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424003484 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326424003485 DNA binding residues [nucleotide binding] 326424003486 dimerization interface [polypeptide binding]; other site 326424003487 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 326424003488 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 326424003489 phosphate binding site [ion binding]; other site 326424003490 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 326424003491 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326424003492 active site 326424003493 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 326424003494 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 326424003495 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 326424003496 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326424003497 putative NADP binding site [chemical binding]; other site 326424003498 active site 326424003499 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 326424003500 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326424003501 active site 326424003502 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 326424003503 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 326424003504 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 326424003505 Phosphopantetheine attachment site; Region: PP-binding; cl09936 326424003506 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 326424003507 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 326424003508 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 326424003509 Methyltransferase domain; Region: Methyltransf_23; pfam13489 326424003510 Methyltransferase domain; Region: Methyltransf_12; pfam08242 326424003511 Putative transcription activator [Transcription]; Region: TenA; COG0819 326424003512 NMT1/THI5 like; Region: NMT1; pfam09084 326424003513 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 326424003514 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424003515 dimer interface [polypeptide binding]; other site 326424003516 conserved gate region; other site 326424003517 putative PBP binding loops; other site 326424003518 ABC-ATPase subunit interface; other site 326424003519 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 326424003520 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 326424003521 Walker A/P-loop; other site 326424003522 ATP binding site [chemical binding]; other site 326424003523 Q-loop/lid; other site 326424003524 ABC transporter signature motif; other site 326424003525 Walker B; other site 326424003526 D-loop; other site 326424003527 H-loop/switch region; other site 326424003528 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 326424003529 Domain of unknown function DUF87; Region: DUF87; pfam01935 326424003530 AAA-like domain; Region: AAA_10; pfam12846 326424003531 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 326424003532 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 326424003533 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 326424003534 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 326424003535 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326424003536 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 326424003537 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 326424003538 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424003539 active site 326424003540 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 326424003541 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 326424003542 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441 326424003543 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 326424003544 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424003545 ATP binding site [chemical binding]; other site 326424003546 Mg2+ binding site [ion binding]; other site 326424003547 G-X-G motif; other site 326424003548 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 326424003549 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424003550 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424003551 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 326424003552 FAD binding domain; Region: FAD_binding_4; pfam01565 326424003553 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 326424003554 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424003555 NAD(P) binding site [chemical binding]; other site 326424003556 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 326424003557 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 326424003558 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 326424003559 phosphopeptide binding site; other site 326424003560 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 326424003561 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 326424003562 phosphopeptide binding site; other site 326424003563 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 326424003564 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 326424003565 Walker A/P-loop; other site 326424003566 ATP binding site [chemical binding]; other site 326424003567 Q-loop/lid; other site 326424003568 ABC transporter signature motif; other site 326424003569 Walker B; other site 326424003570 D-loop; other site 326424003571 H-loop/switch region; other site 326424003572 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 326424003573 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 326424003574 putative active site [active] 326424003575 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424003576 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424003577 active site 326424003578 ATP binding site [chemical binding]; other site 326424003579 substrate binding site [chemical binding]; other site 326424003580 activation loop (A-loop); other site 326424003581 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 326424003582 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 326424003583 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424003584 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424003585 active site 326424003586 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 326424003587 dimer interface [polypeptide binding]; other site 326424003588 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 326424003589 endonuclease III; Region: ENDO3c; smart00478 326424003590 minor groove reading motif; other site 326424003591 helix-hairpin-helix signature motif; other site 326424003592 substrate binding pocket [chemical binding]; other site 326424003593 active site 326424003594 Part of AAA domain; Region: AAA_19; pfam13245 326424003595 Family description; Region: UvrD_C_2; pfam13538 326424003596 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 326424003597 putative dimer interface [polypeptide binding]; other site 326424003598 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326424003599 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 326424003600 FAD binding domain; Region: FAD_binding_4; pfam01565 326424003601 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 326424003602 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 326424003603 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 326424003604 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 326424003605 Ligand binding site; other site 326424003606 Putative Catalytic site; other site 326424003607 DXD motif; other site 326424003608 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 326424003609 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 326424003610 PA14 domain; Region: PA14; cl08459 326424003611 Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250 326424003612 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 326424003613 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 326424003614 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 326424003615 Cu(I) binding site [ion binding]; other site 326424003616 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 326424003617 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 326424003618 active site 326424003619 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 326424003620 phosphopeptide binding site; other site 326424003621 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 326424003622 iron-sulfur cluster [ion binding]; other site 326424003623 [2Fe-2S] cluster binding site [ion binding]; other site 326424003624 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 326424003625 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 326424003626 Zn binding site [ion binding]; other site 326424003627 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326424003628 dimerization interface [polypeptide binding]; other site 326424003629 putative DNA binding site [nucleotide binding]; other site 326424003630 putative Zn2+ binding site [ion binding]; other site 326424003631 SnoaL-like domain; Region: SnoaL_2; pfam12680 326424003632 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 326424003633 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 326424003634 Domain of unknown function (DUF385); Region: DUF385; pfam04075 326424003635 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 326424003636 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 326424003637 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 326424003638 substrate binding site [chemical binding]; other site 326424003639 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424003640 S-adenosylmethionine binding site [chemical binding]; other site 326424003641 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 326424003642 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 326424003643 MarR family; Region: MarR_2; pfam12802 326424003644 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 326424003645 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326424003646 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 326424003647 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 326424003648 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 326424003649 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 326424003650 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424003651 NAD(P) binding site [chemical binding]; other site 326424003652 active site 326424003653 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326424003654 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326424003655 dimer interface [polypeptide binding]; other site 326424003656 phosphorylation site [posttranslational modification] 326424003657 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424003658 ATP binding site [chemical binding]; other site 326424003659 Mg2+ binding site [ion binding]; other site 326424003660 G-X-G motif; other site 326424003661 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326424003662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424003663 active site 326424003664 phosphorylation site [posttranslational modification] 326424003665 intermolecular recognition site; other site 326424003666 dimerization interface [polypeptide binding]; other site 326424003667 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326424003668 DNA binding site [nucleotide binding] 326424003669 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 326424003670 active site 326424003671 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; pfam09837 326424003672 Oxidoreductase molybdopterin binding domain; Region: Oxidored_molyb; pfam00174 326424003673 Moco binding site; other site 326424003674 metal coordination site [ion binding]; other site 326424003675 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424003676 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424003677 FOG: CBS domain [General function prediction only]; Region: COG0517 326424003678 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 326424003679 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 326424003680 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 326424003681 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 326424003682 NAD binding site [chemical binding]; other site 326424003683 substrate binding site [chemical binding]; other site 326424003684 catalytic Zn binding site [ion binding]; other site 326424003685 structural Zn binding site [ion binding]; other site 326424003686 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 326424003687 PAS domain S-box; Region: sensory_box; TIGR00229 326424003688 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 326424003689 putative active site [active] 326424003690 heme pocket [chemical binding]; other site 326424003691 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 326424003692 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 326424003693 metal binding site [ion binding]; metal-binding site 326424003694 active site 326424003695 I-site; other site 326424003696 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 326424003697 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424003698 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 326424003699 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 326424003700 acyl-activating enzyme (AAE) consensus motif; other site 326424003701 acyl-activating enzyme (AAE) consensus motif; other site 326424003702 putative AMP binding site [chemical binding]; other site 326424003703 putative active site [active] 326424003704 putative CoA binding site [chemical binding]; other site 326424003705 CoA binding site [chemical binding]; other site 326424003706 enoyl-CoA hydratase; Provisional; Region: PRK06190 326424003707 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424003708 substrate binding site [chemical binding]; other site 326424003709 oxyanion hole (OAH) forming residues; other site 326424003710 trimer interface [polypeptide binding]; other site 326424003711 MOSC domain; Region: MOSC; pfam03473 326424003712 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 326424003713 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 326424003714 hydrophobic ligand binding site; other site 326424003715 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 326424003716 Low molecular weight phosphatase family; Region: LMWPc; cl00105 326424003717 active site 326424003718 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 326424003719 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326424003720 active site 326424003721 motif I; other site 326424003722 motif II; other site 326424003723 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326424003724 SnoaL-like domain; Region: SnoaL_2; pfam12680 326424003725 Predicted transcriptional regulators [Transcription]; Region: COG1733 326424003726 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 326424003727 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 326424003728 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424003729 substrate binding site [chemical binding]; other site 326424003730 oxyanion hole (OAH) forming residues; other site 326424003731 trimer interface [polypeptide binding]; other site 326424003732 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424003733 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326424003734 DNA binding residues [nucleotide binding] 326424003735 dimerization interface [polypeptide binding]; other site 326424003736 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424003737 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326424003738 DNA binding residues [nucleotide binding] 326424003739 dimerization interface [polypeptide binding]; other site 326424003740 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424003741 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 326424003742 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 326424003743 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 326424003744 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 326424003745 acyl-CoA synthetase; Validated; Region: PRK06188 326424003746 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424003747 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 326424003748 acyl-activating enzyme (AAE) consensus motif; other site 326424003749 putative AMP binding site [chemical binding]; other site 326424003750 putative active site [active] 326424003751 putative CoA binding site [chemical binding]; other site 326424003752 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 326424003753 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 326424003754 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 326424003755 NAD(P) binding site [chemical binding]; other site 326424003756 catalytic residues [active] 326424003757 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424003758 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 326424003759 active site 326424003760 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 326424003761 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 326424003762 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 326424003763 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 326424003764 ATP-grasp domain; Region: ATP-grasp_4; cl17255 326424003765 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 326424003766 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 326424003767 carboxyltransferase (CT) interaction site; other site 326424003768 biotinylation site [posttranslational modification]; other site 326424003769 enoyl-CoA hydratase; Provisional; Region: PRK06494 326424003770 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424003771 substrate binding site [chemical binding]; other site 326424003772 oxyanion hole (OAH) forming residues; other site 326424003773 trimer interface [polypeptide binding]; other site 326424003774 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 326424003775 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424003776 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424003777 active site 326424003778 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 326424003779 TOBE domain; Region: TOBE; cl01440 326424003780 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 326424003781 Male sterility protein; Region: NAD_binding_4; pfam07993 326424003782 NAD(P) binding site [chemical binding]; other site 326424003783 active site 326424003784 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 326424003785 phosphate binding site [ion binding]; other site 326424003786 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326424003787 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 326424003788 active site 326424003789 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 326424003790 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 326424003791 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 326424003792 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 326424003793 putative NADP binding site [chemical binding]; other site 326424003794 KR domain; Region: KR; pfam08659 326424003795 active site 326424003796 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326424003797 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 326424003798 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 326424003799 FtsX-like permease family; Region: FtsX; pfam02687 326424003800 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 326424003801 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 326424003802 Walker A/P-loop; other site 326424003803 ATP binding site [chemical binding]; other site 326424003804 Q-loop/lid; other site 326424003805 ABC transporter signature motif; other site 326424003806 Walker B; other site 326424003807 D-loop; other site 326424003808 H-loop/switch region; other site 326424003809 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 326424003810 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 326424003811 putative NAD(P) binding site [chemical binding]; other site 326424003812 CHAT domain; Region: CHAT; cl17868 326424003813 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 326424003814 DUF35 OB-fold domain; Region: DUF35; pfam01796 326424003815 lipid-transfer protein; Provisional; Region: PRK07855 326424003816 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 326424003817 active site 326424003818 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 326424003819 putative active site [active] 326424003820 putative substrate binding site [chemical binding]; other site 326424003821 ATP binding site [chemical binding]; other site 326424003822 Epoxide hydrolase N terminus; Region: EHN; pfam06441 326424003823 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 326424003824 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 326424003825 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424003826 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 326424003827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 326424003828 S-adenosylmethionine binding site [chemical binding]; other site 326424003829 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 326424003830 Ligand Binding Site [chemical binding]; other site 326424003831 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 326424003832 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 326424003833 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 326424003834 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 326424003835 ring oligomerisation interface [polypeptide binding]; other site 326424003836 ATP/Mg binding site [chemical binding]; other site 326424003837 stacking interactions; other site 326424003838 hinge regions; other site 326424003839 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 326424003840 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326424003841 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 326424003842 active site 326424003843 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 326424003844 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326424003845 putative ADP-binding pocket [chemical binding]; other site 326424003846 Pirin-related protein [General function prediction only]; Region: COG1741 326424003847 Pirin; Region: Pirin; pfam02678 326424003848 MarR family; Region: MarR_2; pfam12802 326424003849 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 326424003850 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 326424003851 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326424003852 motif II; other site 326424003853 AAA domain; Region: AAA_14; pfam13173 326424003854 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 326424003855 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 326424003856 glycoside hydrolase family 64: laminaripentaose-producing, beta-1,3-glucanase (LPHase)-like; Region: GH64-LPHase-like; cd09216 326424003857 substrate binding pocket [chemical binding]; other site 326424003858 catalytic residues [active] 326424003859 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 326424003860 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 326424003861 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 326424003862 active site 326424003863 iron coordination sites [ion binding]; other site 326424003864 substrate binding pocket [chemical binding]; other site 326424003865 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG4034 326424003866 Protein of unknown function (DUF1152); Region: DUF1152; pfam06626 326424003867 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 326424003868 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326424003869 DNA-binding site [nucleotide binding]; DNA binding site 326424003870 UTRA domain; Region: UTRA; pfam07702 326424003871 Frankia-40 domain; Region: Frankia_40_dom; TIGR03917 326424003872 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 326424003873 Helix-turn-helix domain; Region: HTH_17; cl17695 326424003874 Frankia-40 domain; Region: Frankia_40_dom; TIGR03917 326424003875 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 326424003876 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 326424003877 DNA binding site [nucleotide binding] 326424003878 active site 326424003879 Int/Topo IB signature motif; other site 326424003880 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 326424003881 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326424003882 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424003883 Walker A/P-loop; other site 326424003884 ATP binding site [chemical binding]; other site 326424003885 Q-loop/lid; other site 326424003886 ABC transporter signature motif; other site 326424003887 Walker B; other site 326424003888 D-loop; other site 326424003889 H-loop/switch region; other site 326424003890 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 326424003891 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326424003892 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424003893 Walker A/P-loop; other site 326424003894 ATP binding site [chemical binding]; other site 326424003895 Q-loop/lid; other site 326424003896 ABC transporter signature motif; other site 326424003897 Walker B; other site 326424003898 D-loop; other site 326424003899 H-loop/switch region; other site 326424003900 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 326424003901 active site 326424003902 catalytic triad [active] 326424003903 oxyanion hole [active] 326424003904 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 326424003905 putative active site [active] 326424003906 catalytic site [active] 326424003907 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 326424003908 putative active site [active] 326424003909 catalytic site [active] 326424003910 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 326424003911 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 326424003912 putative metal binding site [ion binding]; other site 326424003913 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 326424003914 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 326424003915 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 326424003916 active site 326424003917 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 326424003918 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 326424003919 NodB motif; other site 326424003920 putative active site [active] 326424003921 putative catalytic site [active] 326424003922 putative Zn binding site [ion binding]; other site 326424003923 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 326424003924 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 326424003925 tetramer interface [polypeptide binding]; other site 326424003926 active site 326424003927 Mg2+/Mn2+ binding site [ion binding]; other site 326424003928 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 326424003929 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 326424003930 NAD(P) binding site [chemical binding]; other site 326424003931 catalytic residues [active] 326424003932 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424003933 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424003934 active site 326424003935 phosphorylation site [posttranslational modification] 326424003936 intermolecular recognition site; other site 326424003937 dimerization interface [polypeptide binding]; other site 326424003938 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326424003939 DNA binding residues [nucleotide binding] 326424003940 dimerization interface [polypeptide binding]; other site 326424003941 TIR domain; Region: TIR_2; pfam13676 326424003942 FOG: WD40 repeat [General function prediction only]; Region: COG2319 326424003943 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 326424003944 structural tetrad; other site 326424003945 TIR domain; Region: TIR_2; pfam13676 326424003946 FOG: WD40 repeat [General function prediction only]; Region: COG2319 326424003947 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 326424003948 structural tetrad; other site 326424003949 Helix-turn-helix domain; Region: HTH_17; pfam12728 326424003950 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 326424003951 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 326424003952 Int/Topo IB signature motif; other site 326424003953 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 326424003954 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 326424003955 catalytic site [active] 326424003956 putative active site [active] 326424003957 putative substrate binding site [chemical binding]; other site 326424003958 dimer interface [polypeptide binding]; other site 326424003959 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 326424003960 ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004 326424003961 ATP binding site [chemical binding]; other site 326424003962 Walker B motif; other site 326424003963 arginine finger; other site 326424003964 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 326424003965 Pirin-related protein [General function prediction only]; Region: COG1741 326424003966 Pirin; Region: Pirin; pfam02678 326424003967 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 326424003968 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 326424003969 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 326424003970 ligand binding site [chemical binding]; other site 326424003971 flexible hinge region; other site 326424003972 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 326424003973 HipA-like N-terminal domain; Region: HipA_N; pfam07805 326424003974 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 326424003975 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 326424003976 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 326424003977 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 326424003978 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 326424003979 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 326424003980 NADP-binding site; other site 326424003981 homotetramer interface [polypeptide binding]; other site 326424003982 substrate binding site [chemical binding]; other site 326424003983 homodimer interface [polypeptide binding]; other site 326424003984 active site 326424003985 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 326424003986 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 326424003987 active site 326424003988 catalytic triad [active] 326424003989 oxyanion hole [active] 326424003990 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 326424003991 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 326424003992 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 326424003993 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 326424003994 RNA binding site [nucleotide binding]; other site 326424003995 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 326424003996 RNA binding site [nucleotide binding]; other site 326424003997 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 326424003998 RNA binding site [nucleotide binding]; other site 326424003999 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 326424004000 RNA binding site [nucleotide binding]; other site 326424004001 Trm112p-like protein; Region: Trm112p; cl01066 326424004002 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 326424004003 catalytic residues [active] 326424004004 dimer interface [polypeptide binding]; other site 326424004005 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 326424004006 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 326424004007 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424004008 NAD(P) binding site [chemical binding]; other site 326424004009 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 326424004010 active site 326424004011 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 326424004012 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 326424004013 conserved cys residue [active] 326424004014 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 326424004015 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 326424004016 Cupin; Region: Cupin_6; pfam12852 326424004017 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 326424004018 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 326424004019 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 326424004020 active site 326424004021 HIGH motif; other site 326424004022 nucleotide binding site [chemical binding]; other site 326424004023 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 326424004024 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 326424004025 active site 326424004026 KMSKS motif; other site 326424004027 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 326424004028 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_11; cd13126 326424004029 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 326424004030 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 326424004031 Walker A/P-loop; other site 326424004032 ATP binding site [chemical binding]; other site 326424004033 Q-loop/lid; other site 326424004034 ABC transporter signature motif; other site 326424004035 Walker B; other site 326424004036 D-loop; other site 326424004037 H-loop/switch region; other site 326424004038 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 326424004039 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 326424004040 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 326424004041 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 326424004042 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 326424004043 Predicted ATPase [General function prediction only]; Region: COG3910 326424004044 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 326424004045 Walker A/P-loop; other site 326424004046 ATP binding site [chemical binding]; other site 326424004047 Q-loop/lid; other site 326424004048 ABC transporter signature motif; other site 326424004049 Walker B; other site 326424004050 D-loop; other site 326424004051 H-loop/switch region; other site 326424004052 Methyltransferase domain; Region: Methyltransf_23; pfam13489 326424004053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424004054 S-adenosylmethionine binding site [chemical binding]; other site 326424004055 thiamine pyrophosphate protein; Provisional; Region: PRK08273 326424004056 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 326424004057 PYR/PP interface [polypeptide binding]; other site 326424004058 dimer interface [polypeptide binding]; other site 326424004059 tetramer interface [polypeptide binding]; other site 326424004060 TPP binding site [chemical binding]; other site 326424004061 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 326424004062 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 326424004063 TPP-binding site [chemical binding]; other site 326424004064 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 326424004065 Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755 326424004066 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 326424004067 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 326424004068 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 326424004069 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 326424004070 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326424004071 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 326424004072 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 326424004073 G1 box; other site 326424004074 GTP/Mg2+ binding site [chemical binding]; other site 326424004075 G2 box; other site 326424004076 Switch I region; other site 326424004077 G3 box; other site 326424004078 Switch II region; other site 326424004079 G4 box; other site 326424004080 G5 box; other site 326424004081 Protein of unknown function (DUF742); Region: DUF742; pfam05331 326424004082 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 326424004083 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326424004084 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424004085 ATP binding site [chemical binding]; other site 326424004086 Mg2+ binding site [ion binding]; other site 326424004087 G-X-G motif; other site 326424004088 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 326424004089 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 326424004090 substrate binding site [chemical binding]; other site 326424004091 activation loop (A-loop); other site 326424004092 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 326424004093 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326424004094 ATP binding site [chemical binding]; other site 326424004095 putative Mg++ binding site [ion binding]; other site 326424004096 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326424004097 nucleotide binding region [chemical binding]; other site 326424004098 ATP-binding site [chemical binding]; other site 326424004099 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 326424004100 HRDC domain; Region: HRDC; pfam00570 326424004101 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424004102 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424004103 active site 326424004104 ATP binding site [chemical binding]; other site 326424004105 substrate binding site [chemical binding]; other site 326424004106 activation loop (A-loop); other site 326424004107 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 326424004108 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 326424004109 dimerization interface [polypeptide binding]; other site 326424004110 ATP binding site [chemical binding]; other site 326424004111 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 326424004112 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 326424004113 HupF/HypC family; Region: HupF_HypC; pfam01455 326424004114 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 326424004115 Acylphosphatase; Region: Acylphosphatase; pfam00708 326424004116 HypF finger; Region: zf-HYPF; pfam07503 326424004117 HypF finger; Region: zf-HYPF; pfam07503 326424004118 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 326424004119 NHL repeat; Region: NHL; pfam01436 326424004120 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424004121 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 326424004122 nickel binding site [ion binding]; other site 326424004123 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 326424004124 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 326424004125 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 326424004126 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 326424004127 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 326424004128 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 326424004129 TIR domain; Region: TIR_2; pfam13676 326424004130 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 326424004131 Acyltransferase family; Region: Acyl_transf_3; pfam01757 326424004132 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326424004133 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326424004134 active site 326424004135 catalytic tetrad [active] 326424004136 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 326424004137 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 326424004138 dimer interface [polypeptide binding]; other site 326424004139 ssDNA binding site [nucleotide binding]; other site 326424004140 tetramer (dimer of dimers) interface [polypeptide binding]; other site 326424004141 Uncharacterized conserved protein [Function unknown]; Region: COG5361 326424004142 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 326424004143 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 326424004144 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 326424004145 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326424004146 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326424004147 ABC transporter; Region: ABC_tran_2; pfam12848 326424004148 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326424004149 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 326424004150 apolar tunnel; other site 326424004151 heme binding site [chemical binding]; other site 326424004152 dimerization interface [polypeptide binding]; other site 326424004153 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 326424004154 active site 326424004155 catalytic site [active] 326424004156 GAF domain; Region: GAF_3; pfam13492 326424004157 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 326424004158 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 326424004159 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 326424004160 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 326424004161 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 326424004162 putative NAD(P) binding site [chemical binding]; other site 326424004163 putative active site [active] 326424004164 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 326424004165 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 326424004166 active site 326424004167 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 326424004168 Mechanosensitive ion channel; Region: MS_channel; pfam00924 326424004169 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326424004170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424004171 active site 326424004172 phosphorylation site [posttranslational modification] 326424004173 intermolecular recognition site; other site 326424004174 dimerization interface [polypeptide binding]; other site 326424004175 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326424004176 DNA binding site [nucleotide binding] 326424004177 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326424004178 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 326424004179 dimerization interface [polypeptide binding]; other site 326424004180 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326424004181 dimer interface [polypeptide binding]; other site 326424004182 phosphorylation site [posttranslational modification] 326424004183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424004184 ATP binding site [chemical binding]; other site 326424004185 Mg2+ binding site [ion binding]; other site 326424004186 G-X-G motif; other site 326424004187 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 326424004188 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 326424004189 Repair protein; Region: Repair_PSII; pfam04536 326424004190 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326424004191 dimerization interface [polypeptide binding]; other site 326424004192 putative DNA binding site [nucleotide binding]; other site 326424004193 putative Zn2+ binding site [ion binding]; other site 326424004194 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 326424004195 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 326424004196 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 326424004197 Zn binding site [ion binding]; other site 326424004198 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 326424004199 Domain of unknown function DUF20; Region: UPF0118; pfam01594 326424004200 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 326424004201 catalytic residues [active] 326424004202 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 326424004203 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 326424004204 active site 326424004205 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 326424004206 RyR domain; Region: RyR; pfam02026 326424004207 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 326424004208 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 326424004209 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326424004210 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 326424004211 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 326424004212 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 326424004213 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 326424004214 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326424004215 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326424004216 active site 326424004217 catalytic tetrad [active] 326424004218 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 326424004219 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 326424004220 Walker A/P-loop; other site 326424004221 ATP binding site [chemical binding]; other site 326424004222 Q-loop/lid; other site 326424004223 ABC transporter signature motif; other site 326424004224 Walker B; other site 326424004225 D-loop; other site 326424004226 H-loop/switch region; other site 326424004227 CHASE3 domain; Region: CHASE3; pfam05227 326424004228 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 326424004229 dimerization interface [polypeptide binding]; other site 326424004230 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 326424004231 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 326424004232 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 326424004233 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424004234 AMP-binding enzyme; Region: AMP-binding; pfam00501 326424004235 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424004236 acyl-activating enzyme (AAE) consensus motif; other site 326424004237 acyl-activating enzyme (AAE) consensus motif; other site 326424004238 AMP binding site [chemical binding]; other site 326424004239 active site 326424004240 CoA binding site [chemical binding]; other site 326424004241 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326424004242 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 326424004243 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 326424004244 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 326424004245 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 326424004246 putative catalytic site [active] 326424004247 putative phosphate binding site [ion binding]; other site 326424004248 active site 326424004249 metal binding site A [ion binding]; metal-binding site 326424004250 DNA binding site [nucleotide binding] 326424004251 putative AP binding site [nucleotide binding]; other site 326424004252 putative metal binding site B [ion binding]; other site 326424004253 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 326424004254 RibD C-terminal domain; Region: RibD_C; cl17279 326424004255 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 326424004256 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 326424004257 enterobactin exporter EntS; Provisional; Region: PRK10489 326424004258 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 326424004259 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 326424004260 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 326424004261 active site 326424004262 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 326424004263 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 326424004264 domain_subunit interface; other site 326424004265 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 326424004266 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 326424004267 active site 326424004268 FMN binding site [chemical binding]; other site 326424004269 substrate binding site [chemical binding]; other site 326424004270 3Fe-4S cluster binding site [ion binding]; other site 326424004271 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 326424004272 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326424004273 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424004274 non-specific DNA binding site [nucleotide binding]; other site 326424004275 salt bridge; other site 326424004276 sequence-specific DNA binding site [nucleotide binding]; other site 326424004277 Cupin domain; Region: Cupin_2; pfam07883 326424004278 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 326424004279 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 326424004280 putative dimer interface [polypeptide binding]; other site 326424004281 FHA domain; Region: FHA; pfam00498 326424004282 phosphopeptide binding site; other site 326424004283 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 326424004284 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 326424004285 phosphopeptide binding site; other site 326424004286 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 326424004287 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 326424004288 Walker A/P-loop; other site 326424004289 ATP binding site [chemical binding]; other site 326424004290 Q-loop/lid; other site 326424004291 ABC transporter signature motif; other site 326424004292 Walker B; other site 326424004293 D-loop; other site 326424004294 H-loop/switch region; other site 326424004295 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 326424004296 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 326424004297 Protein of unknown function (DUF962); Region: DUF962; pfam06127 326424004298 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424004299 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326424004300 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 326424004301 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326424004302 DNA-binding site [nucleotide binding]; DNA binding site 326424004303 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326424004304 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326424004305 homodimer interface [polypeptide binding]; other site 326424004306 catalytic residue [active] 326424004307 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 326424004308 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326424004309 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 326424004310 phosphate binding site [ion binding]; other site 326424004311 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 326424004312 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 326424004313 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 326424004314 Methyltransferase domain; Region: Methyltransf_23; pfam13489 326424004315 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424004316 S-adenosylmethionine binding site [chemical binding]; other site 326424004317 trigger factor; Provisional; Region: tig; PRK01490 326424004318 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 326424004319 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 326424004320 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 326424004321 Clp protease; Region: CLP_protease; pfam00574 326424004322 oligomer interface [polypeptide binding]; other site 326424004323 active site residues [active] 326424004324 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 326424004325 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 326424004326 oligomer interface [polypeptide binding]; other site 326424004327 active site residues [active] 326424004328 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 326424004329 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 326424004330 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 326424004331 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326424004332 Walker A motif; other site 326424004333 ATP binding site [chemical binding]; other site 326424004334 Walker B motif; other site 326424004335 arginine finger; other site 326424004336 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 326424004337 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 326424004338 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 326424004339 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 326424004340 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 326424004341 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 326424004342 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 326424004343 active site 326424004344 multimer interface [polypeptide binding]; other site 326424004345 rod shape-determining protein MreB; Provisional; Region: PRK13927 326424004346 MreB and similar proteins; Region: MreB_like; cd10225 326424004347 nucleotide binding site [chemical binding]; other site 326424004348 Mg binding site [ion binding]; other site 326424004349 putative protofilament interaction site [polypeptide binding]; other site 326424004350 RodZ interaction site [polypeptide binding]; other site 326424004351 rod shape-determining protein MreC; Provisional; Region: PRK13922 326424004352 rod shape-determining protein MreC; Region: MreC; pfam04085 326424004353 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 326424004354 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 326424004355 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 326424004356 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 326424004357 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 326424004358 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 326424004359 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 326424004360 B12 binding site [chemical binding]; other site 326424004361 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326424004362 FeS/SAM binding site; other site 326424004363 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 326424004364 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 326424004365 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 326424004366 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 326424004367 homodimer interface [polypeptide binding]; other site 326424004368 oligonucleotide binding site [chemical binding]; other site 326424004369 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 326424004370 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 326424004371 GTPase CgtA; Reviewed; Region: obgE; PRK12297 326424004372 GTP1/OBG; Region: GTP1_OBG; pfam01018 326424004373 Obg GTPase; Region: Obg; cd01898 326424004374 G1 box; other site 326424004375 GTP/Mg2+ binding site [chemical binding]; other site 326424004376 Switch I region; other site 326424004377 G2 box; other site 326424004378 G3 box; other site 326424004379 Switch II region; other site 326424004380 G4 box; other site 326424004381 G5 box; other site 326424004382 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 326424004383 gamma-glutamyl kinase; Provisional; Region: PRK05429 326424004384 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 326424004385 nucleotide binding site [chemical binding]; other site 326424004386 homotetrameric interface [polypeptide binding]; other site 326424004387 putative phosphate binding site [ion binding]; other site 326424004388 putative allosteric binding site; other site 326424004389 PUA domain; Region: PUA; pfam01472 326424004390 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 326424004391 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424004392 Walker A/P-loop; other site 326424004393 ATP binding site [chemical binding]; other site 326424004394 Q-loop/lid; other site 326424004395 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 326424004396 ABC transporter signature motif; other site 326424004397 Walker B; other site 326424004398 D-loop; other site 326424004399 H-loop/switch region; other site 326424004400 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 326424004401 active site 326424004402 metal binding site [ion binding]; metal-binding site 326424004403 DNA binding site [nucleotide binding] 326424004404 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 326424004405 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 326424004406 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 326424004407 putative catalytic cysteine [active] 326424004408 MoxR-like ATPases [General function prediction only]; Region: COG0714 326424004409 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326424004410 Walker A motif; other site 326424004411 ATP binding site [chemical binding]; other site 326424004412 Walker B motif; other site 326424004413 arginine finger; other site 326424004414 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 326424004415 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 326424004416 phosphoglucomutase; Validated; Region: PRK07564 326424004417 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 326424004418 active site 326424004419 substrate binding site [chemical binding]; other site 326424004420 metal binding site [ion binding]; metal-binding site 326424004421 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 326424004422 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 326424004423 active site 326424004424 (T/H)XGH motif; other site 326424004425 Oligomerisation domain; Region: Oligomerisation; cl00519 326424004426 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 326424004427 catalytic core [active] 326424004428 Protein of unknown function (DUF3494); Region: DUF3494; pfam11999 326424004429 Methyltransferase domain; Region: Methyltransf_31; pfam13847 326424004430 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424004431 S-adenosylmethionine binding site [chemical binding]; other site 326424004432 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 326424004433 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 326424004434 active site 2 [active] 326424004435 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 326424004436 catalytic triad [active] 326424004437 dimer interface [polypeptide binding]; other site 326424004438 AMP-binding enzyme; Region: AMP-binding; pfam00501 326424004439 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424004440 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 326424004441 acyl-activating enzyme (AAE) consensus motif; other site 326424004442 acyl-activating enzyme (AAE) consensus motif; other site 326424004443 putative AMP binding site [chemical binding]; other site 326424004444 putative active site [active] 326424004445 putative CoA binding site [chemical binding]; other site 326424004446 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 326424004447 PAS domain; Region: PAS_9; pfam13426 326424004448 putative active site [active] 326424004449 heme pocket [chemical binding]; other site 326424004450 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 326424004451 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 326424004452 metal binding site [ion binding]; metal-binding site 326424004453 active site 326424004454 I-site; other site 326424004455 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 326424004456 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424004457 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424004458 Enoylreductase; Region: PKS_ER; smart00829 326424004459 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 326424004460 NAD(P) binding site [chemical binding]; other site 326424004461 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 326424004462 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424004463 short chain dehydrogenase; Provisional; Region: PRK07062 326424004464 NAD(P) binding site [chemical binding]; other site 326424004465 active site 326424004466 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 326424004467 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 326424004468 active site 326424004469 TDP-binding site; other site 326424004470 acceptor substrate-binding pocket; other site 326424004471 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 326424004472 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 326424004473 ligand binding site [chemical binding]; other site 326424004474 flexible hinge region; other site 326424004475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424004476 ATP binding site [chemical binding]; other site 326424004477 Mg2+ binding site [ion binding]; other site 326424004478 G-X-G motif; other site 326424004479 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 326424004480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424004481 active site 326424004482 phosphorylation site [posttranslational modification] 326424004483 intermolecular recognition site; other site 326424004484 dimerization interface [polypeptide binding]; other site 326424004485 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 326424004486 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 326424004487 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 326424004488 FOG: WD40 repeat [General function prediction only]; Region: COG2319 326424004489 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 326424004490 structural tetrad; other site 326424004491 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 326424004492 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 326424004493 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 326424004494 putative active site [active] 326424004495 catalytic triad [active] 326424004496 putative dimer interface [polypeptide binding]; other site 326424004497 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 326424004498 6-phosphofructokinase; Region: PLN02564 326424004499 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 326424004500 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424004501 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424004502 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 326424004503 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326424004504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424004505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424004506 Putative sensor; Region: Sensor; pfam13796 326424004507 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 326424004508 Histidine kinase; Region: HisKA_3; pfam07730 326424004509 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 326424004510 Mg2+ binding site [ion binding]; other site 326424004511 G-X-G motif; other site 326424004512 PAC2 family; Region: PAC2; pfam09754 326424004513 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 326424004514 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 326424004515 putative NADP binding site [chemical binding]; other site 326424004516 putative substrate binding site [chemical binding]; other site 326424004517 active site 326424004518 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 326424004519 putative ligand binding site [chemical binding]; other site 326424004520 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 326424004521 putative NAD binding site [chemical binding]; other site 326424004522 catalytic site [active] 326424004523 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 326424004524 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424004525 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424004526 active site 326424004527 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 326424004528 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 326424004529 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 326424004530 Membrane transport protein; Region: Mem_trans; cl09117 326424004531 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 326424004532 Fatty acid desaturase; Region: FA_desaturase; pfam00487 326424004533 Di-iron ligands [ion binding]; other site 326424004534 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 326424004535 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 326424004536 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 326424004537 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 326424004538 active site 326424004539 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 326424004540 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 326424004541 Uncharacterized conserved protein [Function unknown]; Region: COG2353 326424004542 SLBB domain; Region: SLBB; pfam10531 326424004543 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 326424004544 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 326424004545 Competence protein; Region: Competence; pfam03772 326424004546 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 326424004547 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 326424004548 hypothetical protein; Reviewed; Region: PRK07914 326424004549 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 326424004550 GTP-binding protein LepA; Provisional; Region: PRK05433 326424004551 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 326424004552 G1 box; other site 326424004553 putative GEF interaction site [polypeptide binding]; other site 326424004554 GTP/Mg2+ binding site [chemical binding]; other site 326424004555 Switch I region; other site 326424004556 G2 box; other site 326424004557 G3 box; other site 326424004558 Switch II region; other site 326424004559 G4 box; other site 326424004560 G5 box; other site 326424004561 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 326424004562 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 326424004563 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 326424004564 coproporphyrinogen III oxidase; Validated; Region: PRK05628 326424004565 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326424004566 FeS/SAM binding site; other site 326424004567 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 326424004568 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 326424004569 chaperone protein DnaJ; Provisional; Region: PRK14278 326424004570 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 326424004571 HSP70 interaction site [polypeptide binding]; other site 326424004572 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 326424004573 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 326424004574 dimer interface [polypeptide binding]; other site 326424004575 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 326424004576 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 326424004577 PhoH-like protein; Region: PhoH; pfam02562 326424004578 metal-binding heat shock protein; Provisional; Region: PRK00016 326424004579 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 326424004580 Domain of unknown function DUF21; Region: DUF21; pfam01595 326424004581 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 326424004582 Transporter associated domain; Region: CorC_HlyC; smart01091 326424004583 GTPase Era; Reviewed; Region: era; PRK00089 326424004584 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 326424004585 G1 box; other site 326424004586 GTP/Mg2+ binding site [chemical binding]; other site 326424004587 Switch I region; other site 326424004588 G2 box; other site 326424004589 Switch II region; other site 326424004590 G3 box; other site 326424004591 G4 box; other site 326424004592 G5 box; other site 326424004593 KH domain; Region: KH_2; pfam07650 326424004594 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 326424004595 nudix motif; other site 326424004596 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 326424004597 Recombination protein O N terminal; Region: RecO_N; pfam11967 326424004598 Recombination protein O C terminal; Region: RecO_C; pfam02565 326424004599 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 326424004600 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 326424004601 catalytic residue [active] 326424004602 putative FPP diphosphate binding site; other site 326424004603 putative FPP binding hydrophobic cleft; other site 326424004604 dimer interface [polypeptide binding]; other site 326424004605 putative IPP diphosphate binding site; other site 326424004606 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 326424004607 motif 1; other site 326424004608 dimer interface [polypeptide binding]; other site 326424004609 active site 326424004610 motif 2; other site 326424004611 motif 3; other site 326424004612 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 326424004613 Uncharacterized conserved protein [Function unknown]; Region: COG1434 326424004614 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 326424004615 putative active site [active] 326424004616 transketolase; Reviewed; Region: PRK05899 326424004617 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 326424004618 TPP-binding site [chemical binding]; other site 326424004619 dimer interface [polypeptide binding]; other site 326424004620 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 326424004621 PYR/PP interface [polypeptide binding]; other site 326424004622 dimer interface [polypeptide binding]; other site 326424004623 TPP binding site [chemical binding]; other site 326424004624 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 326424004625 Bacterial PH domain; Region: DUF304; pfam03703 326424004626 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 326424004627 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 326424004628 DNA primase; Validated; Region: dnaG; PRK05667 326424004629 CHC2 zinc finger; Region: zf-CHC2; cl17510 326424004630 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 326424004631 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 326424004632 active site 326424004633 metal binding site [ion binding]; metal-binding site 326424004634 interdomain interaction site; other site 326424004635 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 326424004636 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 326424004637 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 326424004638 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 326424004639 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 326424004640 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326424004641 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 326424004642 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 326424004643 DNA binding residues [nucleotide binding] 326424004644 Methyltransferase domain; Region: Methyltransf_23; pfam13489 326424004645 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424004646 S-adenosylmethionine binding site [chemical binding]; other site 326424004647 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326424004648 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 326424004649 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 326424004650 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326424004651 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 326424004652 Methyltransferase domain; Region: Methyltransf_23; pfam13489 326424004653 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424004654 S-adenosylmethionine binding site [chemical binding]; other site 326424004655 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 326424004656 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 326424004657 active site 326424004658 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 326424004659 active site 326424004660 catalytic site [active] 326424004661 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 326424004662 metal binding site [ion binding]; metal-binding site 326424004663 active site 326424004664 I-site; other site 326424004665 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 326424004666 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 326424004667 Low molecular weight phosphatase family; Region: LMWPc; cl00105 326424004668 active site 326424004669 Macrocin-O-methyltransferase (TylF); Region: TylF; pfam05711 326424004670 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 326424004671 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326424004672 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 326424004673 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424004674 NAD(P) binding site [chemical binding]; other site 326424004675 active site 326424004676 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 326424004677 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 326424004678 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 326424004679 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 326424004680 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 326424004681 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 326424004682 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 326424004683 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 326424004684 active site 326424004685 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 326424004686 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 326424004687 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 326424004688 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 326424004689 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 326424004690 putative metal binding site; other site 326424004691 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 326424004692 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326424004693 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424004694 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 326424004695 NAD(P) binding site [chemical binding]; other site 326424004696 active site 326424004697 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 326424004698 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 326424004699 putative glycosyl transferase; Provisional; Region: PRK10307 326424004700 extended (e) SDRs; Region: SDR_e; cd08946 326424004701 substrate binding site [chemical binding]; other site 326424004702 active site 326424004703 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 326424004704 Mg++ binding site [ion binding]; other site 326424004705 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 326424004706 putative catalytic motif [active] 326424004707 putative substrate binding site [chemical binding]; other site 326424004708 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 326424004709 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 326424004710 putative NAD(P) binding site [chemical binding]; other site 326424004711 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 326424004712 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 326424004713 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 326424004714 NADP-binding site; other site 326424004715 homotetramer interface [polypeptide binding]; other site 326424004716 substrate binding site [chemical binding]; other site 326424004717 homodimer interface [polypeptide binding]; other site 326424004718 active site 326424004719 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 326424004720 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 326424004721 homodimer interface [polypeptide binding]; other site 326424004722 active site 326424004723 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 326424004724 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 326424004725 NAD binding site [chemical binding]; other site 326424004726 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 326424004727 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 326424004728 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326424004729 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 326424004730 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 326424004731 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326424004732 Methyltransferase domain; Region: Methyltransf_23; pfam13489 326424004733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424004734 S-adenosylmethionine binding site [chemical binding]; other site 326424004735 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 326424004736 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 326424004737 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 326424004738 active site 326424004739 trimer interface [polypeptide binding]; other site 326424004740 substrate binding site [chemical binding]; other site 326424004741 CoA binding site [chemical binding]; other site 326424004742 aconitate hydratase; Validated; Region: PRK09277 326424004743 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 326424004744 substrate binding site [chemical binding]; other site 326424004745 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 326424004746 ligand binding site [chemical binding]; other site 326424004747 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 326424004748 substrate binding site [chemical binding]; other site 326424004749 Evidence 2b : Function of strongly homologous gene; PubMedId : 10361288; Product type e : enzyme 326424004750 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 326424004751 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326424004752 metal binding site [ion binding]; metal-binding site 326424004753 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424004754 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424004755 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 326424004756 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 326424004757 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 326424004758 active site 326424004759 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 326424004760 homodimer interface [polypeptide binding]; other site 326424004761 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 326424004762 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 326424004763 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 326424004764 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 326424004765 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326424004766 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 326424004767 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 326424004768 active site 326424004769 dimerization interface [polypeptide binding]; other site 326424004770 tRNA synthetases class I (I, L, M and V); Region: tRNA-synt_1; pfam00133 326424004771 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 326424004772 active site 326424004773 HIGH motif; other site 326424004774 nucleotide binding site [chemical binding]; other site 326424004775 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 326424004776 active site 326424004777 KMSKS motif; other site 326424004778 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 326424004779 tRNA binding surface [nucleotide binding]; other site 326424004780 anticodon binding site; other site 326424004781 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 326424004782 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 326424004783 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 326424004784 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326424004785 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 326424004786 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 326424004787 trimer interface [polypeptide binding]; other site 326424004788 putative metal binding site [ion binding]; other site 326424004789 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 326424004790 trimer interface [polypeptide binding]; other site 326424004791 active site 326424004792 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 326424004793 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 326424004794 generic binding surface II; other site 326424004795 ssDNA binding site; other site 326424004796 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 326424004797 TrkA-N domain; Region: TrkA_N; pfam02254 326424004798 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 326424004799 TrkA-C domain; Region: TrkA_C; pfam02080 326424004800 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 326424004801 TrkA-N domain; Region: TrkA_N; pfam02254 326424004802 TrkA-C domain; Region: TrkA_C; pfam02080 326424004803 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 326424004804 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 326424004805 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 326424004806 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 326424004807 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 326424004808 TPP-binding site; other site 326424004809 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 326424004810 PYR/PP interface [polypeptide binding]; other site 326424004811 dimer interface [polypeptide binding]; other site 326424004812 TPP binding site [chemical binding]; other site 326424004813 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 326424004814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424004815 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326424004816 putative substrate translocation pore; other site 326424004817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424004818 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424004819 Uncharacterized conserved protein [Function unknown]; Region: COG1479 326424004820 Protein of unknown function DUF262; Region: DUF262; pfam03235 326424004821 HipA N-terminal domain; Region: Couple_hipA; pfam13657 326424004822 HipA-like N-terminal domain; Region: HipA_N; pfam07805 326424004823 HipA-like C-terminal domain; Region: HipA_C; pfam07804 326424004824 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424004825 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 326424004826 substrate binding site [chemical binding]; other site 326424004827 oxyanion hole (OAH) forming residues; other site 326424004828 trimer interface [polypeptide binding]; other site 326424004829 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 326424004830 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 326424004831 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 326424004832 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 326424004833 dimer interface [polypeptide binding]; other site 326424004834 active site 326424004835 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 326424004836 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 326424004837 catalytic site [active] 326424004838 putative active site [active] 326424004839 putative substrate binding site [chemical binding]; other site 326424004840 HRDC domain; Region: HRDC; pfam00570 326424004841 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 326424004842 integral membrane protein; Region: integ_memb_HG; TIGR03954 326424004843 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 326424004844 substrate binding site [chemical binding]; other site 326424004845 active site 326424004846 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 326424004847 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 326424004848 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 326424004849 Bacterial sugar transferase; Region: Bac_transf; pfam02397 326424004850 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 326424004851 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 326424004852 ligand-binding site [chemical binding]; other site 326424004853 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 326424004854 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 326424004855 active site 326424004856 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 326424004857 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 326424004858 Active Sites [active] 326424004859 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 326424004860 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 326424004861 CysD dimerization site [polypeptide binding]; other site 326424004862 G1 box; other site 326424004863 putative GEF interaction site [polypeptide binding]; other site 326424004864 GTP/Mg2+ binding site [chemical binding]; other site 326424004865 Switch I region; other site 326424004866 G2 box; other site 326424004867 G3 box; other site 326424004868 Switch II region; other site 326424004869 G4 box; other site 326424004870 G5 box; other site 326424004871 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 326424004872 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 326424004873 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 326424004874 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 326424004875 active site 326424004876 DNA binding site [nucleotide binding] 326424004877 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 326424004878 DNA binding site [nucleotide binding] 326424004879 hypothetical protein; Provisional; Region: PRK14059 326424004880 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 326424004881 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 326424004882 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 326424004883 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 326424004884 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 326424004885 catalytic site [active] 326424004886 active site 326424004887 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 326424004888 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 326424004889 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 326424004890 active site 326424004891 catalytic site [active] 326424004892 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 326424004893 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 326424004894 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 326424004895 active site 326424004896 catalytic site [active] 326424004897 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 326424004898 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 326424004899 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 326424004900 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 326424004901 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 326424004902 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 326424004903 Isochorismatase family; Region: Isochorismatase; pfam00857 326424004904 catalytic triad [active] 326424004905 conserved cis-peptide bond; other site 326424004906 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 326424004907 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 326424004908 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 326424004909 active site 326424004910 metal binding site [ion binding]; metal-binding site 326424004911 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 326424004912 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 326424004913 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 326424004914 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 326424004915 nucleotide binding site/active site [active] 326424004916 HIT family signature motif; other site 326424004917 catalytic residue [active] 326424004918 elongation factor G; Reviewed; Region: PRK12740 326424004919 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 326424004920 G1 box; other site 326424004921 GTP/Mg2+ binding site [chemical binding]; other site 326424004922 G2 box; other site 326424004923 Switch I region; other site 326424004924 G3 box; other site 326424004925 Switch II region; other site 326424004926 G4 box; other site 326424004927 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 326424004928 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 326424004929 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 326424004930 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 326424004931 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 326424004932 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 326424004933 putative acyl-acceptor binding pocket; other site 326424004934 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326424004935 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 326424004936 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 326424004937 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 326424004938 active site 326424004939 multimer interface [polypeptide binding]; other site 326424004940 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 326424004941 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13143 326424004942 predicted active site [active] 326424004943 catalytic triad [active] 326424004944 hypothetical protein; Validated; Region: PRK00110 326424004945 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 326424004946 active site 326424004947 putative DNA-binding cleft [nucleotide binding]; other site 326424004948 dimer interface [polypeptide binding]; other site 326424004949 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 326424004950 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 326424004951 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326424004952 Walker A motif; other site 326424004953 ATP binding site [chemical binding]; other site 326424004954 Walker B motif; other site 326424004955 arginine finger; other site 326424004956 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 326424004957 Preprotein translocase subunit; Region: YajC; pfam02699 326424004958 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 326424004959 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 326424004960 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 326424004961 Protein export membrane protein; Region: SecD_SecF; pfam02355 326424004962 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326424004963 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 326424004964 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 326424004965 Zn2+ binding site [ion binding]; other site 326424004966 Mg2+ binding site [ion binding]; other site 326424004967 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 326424004968 synthetase active site [active] 326424004969 NTP binding site [chemical binding]; other site 326424004970 metal binding site [ion binding]; metal-binding site 326424004971 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 326424004972 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 326424004973 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 326424004974 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 326424004975 Zn2+ binding site [ion binding]; other site 326424004976 Mg2+ binding site [ion binding]; other site 326424004977 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 326424004978 synthetase active site [active] 326424004979 NTP binding site [chemical binding]; other site 326424004980 metal binding site [ion binding]; metal-binding site 326424004981 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 326424004982 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 326424004983 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 326424004984 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 326424004985 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424004986 non-specific DNA binding site [nucleotide binding]; other site 326424004987 salt bridge; other site 326424004988 sequence-specific DNA binding site [nucleotide binding]; other site 326424004989 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 326424004990 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326424004991 ATP binding site [chemical binding]; other site 326424004992 putative Mg++ binding site [ion binding]; other site 326424004993 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 326424004994 active site 326424004995 seryl-tRNA synthetase; Provisional; Region: PRK05431 326424004996 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 326424004997 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 326424004998 dimer interface [polypeptide binding]; other site 326424004999 active site 326424005000 motif 1; other site 326424005001 motif 2; other site 326424005002 motif 3; other site 326424005003 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 326424005004 active site lid residues [active] 326424005005 substrate binding pocket [chemical binding]; other site 326424005006 catalytic residues [active] 326424005007 substrate-Mg2+ binding site; other site 326424005008 aspartate-rich region 1; other site 326424005009 aspartate-rich region 2; other site 326424005010 Domain of unknown function (DUF222); Region: DUF222; pfam02720 326424005011 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 326424005012 metal ion-dependent adhesion site (MIDAS); other site 326424005013 Protein of unknown function DUF58; Region: DUF58; pfam01882 326424005014 MoxR-like ATPases [General function prediction only]; Region: COG0714 326424005015 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326424005016 Walker A motif; other site 326424005017 ATP binding site [chemical binding]; other site 326424005018 Walker B motif; other site 326424005019 arginine finger; other site 326424005020 phytoene desaturase; Region: crtI_fam; TIGR02734 326424005021 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 326424005022 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 326424005023 substrate binding pocket [chemical binding]; other site 326424005024 chain length determination region; other site 326424005025 substrate-Mg2+ binding site; other site 326424005026 catalytic residues [active] 326424005027 aspartate-rich region 1; other site 326424005028 active site lid residues [active] 326424005029 aspartate-rich region 2; other site 326424005030 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 326424005031 FAD binding site [chemical binding]; other site 326424005032 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 326424005033 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 326424005034 metal coordination site [ion binding]; other site 326424005035 phytoene desaturase; Region: crtI_fam; TIGR02734 326424005036 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 326424005037 active site 326424005038 Protein of unknown function (DUF422); Region: DUF422; cl00991 326424005039 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326424005040 Coenzyme A binding pocket [chemical binding]; other site 326424005041 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 326424005042 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 326424005043 NAD binding site [chemical binding]; other site 326424005044 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 326424005045 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 326424005046 DNA binding site [nucleotide binding] 326424005047 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 326424005048 NB-ARC domain; Region: NB-ARC; pfam00931 326424005049 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424005050 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 326424005051 binding surface 326424005052 TPR motif; other site 326424005053 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424005054 DNA Polymerase Y-family; Region: PolY_like; cd03468 326424005055 DNA binding site [nucleotide binding] 326424005056 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 326424005057 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 326424005058 active site 326424005059 PHP Thumb interface [polypeptide binding]; other site 326424005060 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 326424005061 generic binding surface II; other site 326424005062 generic binding surface I; other site 326424005063 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424005064 S-adenosylmethionine binding site [chemical binding]; other site 326424005065 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 326424005066 DNA binding site [nucleotide binding] 326424005067 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 326424005068 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 326424005069 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 326424005070 Protein of unknown function DUF58; Region: DUF58; pfam01882 326424005071 MoxR-like ATPases [General function prediction only]; Region: COG0714 326424005072 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326424005073 Walker A motif; other site 326424005074 ATP binding site [chemical binding]; other site 326424005075 Walker B motif; other site 326424005076 arginine finger; other site 326424005077 cell division protein MraZ; Reviewed; Region: PRK00326 326424005078 MraZ protein; Region: MraZ; pfam02381 326424005079 MraZ protein; Region: MraZ; pfam02381 326424005080 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 326424005081 MraW methylase family; Region: Methyltransf_5; cl17771 326424005082 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 326424005083 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 326424005084 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 326424005085 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 326424005086 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 326424005087 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 326424005088 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 326424005089 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 326424005090 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 326424005091 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 326424005092 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 326424005093 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 326424005094 Mg++ binding site [ion binding]; other site 326424005095 putative catalytic motif [active] 326424005096 putative substrate binding site [chemical binding]; other site 326424005097 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 326424005098 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 326424005099 cell division protein FtsW; Region: ftsW; TIGR02614 326424005100 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 326424005101 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 326424005102 active site 326424005103 homodimer interface [polypeptide binding]; other site 326424005104 Domain of unknown function (DUF385); Region: DUF385; pfam04075 326424005105 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 326424005106 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 326424005107 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 326424005108 cell division protein FtsZ; Validated; Region: PRK09330 326424005109 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 326424005110 nucleotide binding site [chemical binding]; other site 326424005111 SulA interaction site; other site 326424005112 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 326424005113 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 326424005114 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 326424005115 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 326424005116 catalytic residue [active] 326424005117 Protein of unknown function (DUF552); Region: DUF552; cl00775 326424005118 DivIVA protein; Region: DivIVA; pfam05103 326424005119 DivIVA domain; Region: DivI1A_domain; TIGR03544 326424005120 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 326424005121 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 326424005122 HIGH motif; other site 326424005123 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 326424005124 active site 326424005125 KMSKS motif; other site 326424005126 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 326424005127 tRNA binding surface [nucleotide binding]; other site 326424005128 anticodon binding site; other site 326424005129 lipoprotein signal peptidase; Provisional; Region: PRK14764 326424005130 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 326424005131 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 326424005132 RNA binding surface [nucleotide binding]; other site 326424005133 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 326424005134 active site 326424005135 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424005136 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 326424005137 Walker A/P-loop; other site 326424005138 ATP binding site [chemical binding]; other site 326424005139 Q-loop/lid; other site 326424005140 ABC transporter signature motif; other site 326424005141 Walker B; other site 326424005142 D-loop; other site 326424005143 H-loop/switch region; other site 326424005144 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 326424005145 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 326424005146 active site 326424005147 Uncharacterized conserved protein [Function unknown]; Region: COG0327 326424005148 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 326424005149 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 326424005150 Putative zinc ribbon domain; Region: DUF164; pfam02591 326424005151 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 326424005152 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 326424005153 RNA/DNA hybrid binding site [nucleotide binding]; other site 326424005154 active site 326424005155 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 326424005156 catalytic core [active] 326424005157 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 326424005158 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 326424005159 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 326424005160 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 326424005161 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424005162 DNA binding residues [nucleotide binding] 326424005163 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 326424005164 Protein kinase domain; Region: Pkinase; pfam00069 326424005165 active site 326424005166 ATP binding site [chemical binding]; other site 326424005167 substrate binding site [chemical binding]; other site 326424005168 activation loop (A-loop); other site 326424005169 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 326424005170 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424005171 active site 326424005172 ATP binding site [chemical binding]; other site 326424005173 substrate binding site [chemical binding]; other site 326424005174 activation loop (A-loop); other site 326424005175 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 326424005176 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 326424005177 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 326424005178 NAD binding site [chemical binding]; other site 326424005179 catalytic Zn binding site [ion binding]; other site 326424005180 substrate binding site [chemical binding]; other site 326424005181 structural Zn binding site [ion binding]; other site 326424005182 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 326424005183 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 326424005184 P-loop; other site 326424005185 Magnesium ion binding site [ion binding]; other site 326424005186 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 326424005187 Magnesium ion binding site [ion binding]; other site 326424005188 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 326424005189 active site 326424005190 putative substrate binding region [chemical binding]; other site 326424005191 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 326424005192 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 326424005193 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 326424005194 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 326424005195 RNA binding surface [nucleotide binding]; other site 326424005196 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 326424005197 active site 326424005198 prephenate dehydrogenase; Validated; Region: PRK06545 326424005199 prephenate dehydrogenase; Validated; Region: PRK08507 326424005200 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 326424005201 cytidylate kinase; Provisional; Region: cmk; PRK00023 326424005202 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 326424005203 CMP-binding site; other site 326424005204 The sites determining sugar specificity; other site 326424005205 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 326424005206 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 326424005207 putative acyl-acceptor binding pocket; other site 326424005208 GTP-binding protein Der; Reviewed; Region: PRK03003 326424005209 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 326424005210 G1 box; other site 326424005211 GTP/Mg2+ binding site [chemical binding]; other site 326424005212 Switch I region; other site 326424005213 G2 box; other site 326424005214 Switch II region; other site 326424005215 G3 box; other site 326424005216 G4 box; other site 326424005217 G5 box; other site 326424005218 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 326424005219 G1 box; other site 326424005220 GTP/Mg2+ binding site [chemical binding]; other site 326424005221 Switch I region; other site 326424005222 G2 box; other site 326424005223 G3 box; other site 326424005224 Switch II region; other site 326424005225 G4 box; other site 326424005226 G5 box; other site 326424005227 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 326424005228 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 326424005229 putative NAD(P) binding site [chemical binding]; other site 326424005230 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424005231 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 326424005232 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 326424005233 active site 326424005234 putative catalytic site [active] 326424005235 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 326424005236 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 326424005237 NlpC/P60 family; Region: NLPC_P60; pfam00877 326424005238 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 326424005239 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 326424005240 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 326424005241 active site 326424005242 Substrate binding site; other site 326424005243 Mg++ binding site; other site 326424005244 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 326424005245 putative trimer interface [polypeptide binding]; other site 326424005246 putative CoA binding site [chemical binding]; other site 326424005247 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 326424005248 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 326424005249 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 326424005250 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 326424005251 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 326424005252 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 326424005253 lipoyl attachment site [posttranslational modification]; other site 326424005254 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 326424005255 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 326424005256 phosphopeptide binding site; other site 326424005257 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 326424005258 DNA binding residues [nucleotide binding] 326424005259 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 326424005260 Bifunctional nuclease; Region: DNase-RNase; pfam02577 326424005261 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 326424005262 DNA binding residues [nucleotide binding] 326424005263 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 326424005264 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424005265 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 326424005266 Walker A/P-loop; other site 326424005267 ATP binding site [chemical binding]; other site 326424005268 Q-loop/lid; other site 326424005269 ABC transporter signature motif; other site 326424005270 Walker B; other site 326424005271 D-loop; other site 326424005272 H-loop/switch region; other site 326424005273 ABC-2 type transporter; Region: ABC2_membrane; cl17235 326424005274 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 326424005275 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 326424005276 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 326424005277 active site 326424005278 homotetramer interface [polypeptide binding]; other site 326424005279 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 326424005280 catalytic core [active] 326424005281 Transcription factor WhiB; Region: Whib; pfam02467 326424005282 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 326424005283 active site residue [active] 326424005284 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 326424005285 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 326424005286 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 326424005287 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 326424005288 Histidine kinase; Region: HisKA_3; pfam07730 326424005289 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424005290 ATP binding site [chemical binding]; other site 326424005291 Mg2+ binding site [ion binding]; other site 326424005292 G-X-G motif; other site 326424005293 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424005294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424005295 active site 326424005296 phosphorylation site [posttranslational modification] 326424005297 intermolecular recognition site; other site 326424005298 dimerization interface [polypeptide binding]; other site 326424005299 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326424005300 DNA binding residues [nucleotide binding] 326424005301 dimerization interface [polypeptide binding]; other site 326424005302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424005303 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326424005304 Domain of unknown function (DUF222); Region: DUF222; pfam02720 326424005305 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 326424005306 active site 326424005307 Rhomboid family; Region: Rhomboid; pfam01694 326424005308 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 326424005309 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 326424005310 inhibitor-cofactor binding pocket; inhibition site 326424005311 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326424005312 catalytic residue [active] 326424005313 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 326424005314 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 326424005315 metal binding site [ion binding]; metal-binding site 326424005316 active site 326424005317 I-site; other site 326424005318 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 326424005319 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 326424005320 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain; Region: THF_DHG_CYH_C; pfam02882 326424005321 NAD(P) binding pocket [chemical binding]; other site 326424005322 tetracycline repressor protein TetR; Provisional; Region: PRK13756 326424005323 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424005324 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 326424005325 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326424005326 Coenzyme A binding pocket [chemical binding]; other site 326424005327 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 326424005328 HTH domain; Region: HTH_11; pfam08279 326424005329 WYL domain; Region: WYL; pfam13280 326424005330 Protein of unknown function (DUF456); Region: DUF456; pfam04306 326424005331 Amidinotransferase; Region: Amidinotransf; cl12043 326424005332 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 326424005333 MarR family; Region: MarR_2; pfam12802 326424005334 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 326424005335 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 326424005336 active site 326424005337 catalytic site [active] 326424005338 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 326424005339 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 326424005340 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 326424005341 putative active site [active] 326424005342 putative substrate binding site [chemical binding]; other site 326424005343 putative cosubstrate binding site; other site 326424005344 catalytic site [active] 326424005345 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 326424005346 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 326424005347 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 326424005348 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 326424005349 active site 326424005350 metal binding site [ion binding]; metal-binding site 326424005351 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 326424005352 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 326424005353 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 326424005354 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 326424005355 putative metal binding site [ion binding]; other site 326424005356 TIR domain; Region: TIR_2; cl17458 326424005357 TIR domain; Region: TIR_2; pfam13676 326424005358 TIR domain; Region: TIR_2; pfam13676 326424005359 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 326424005360 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 326424005361 P-loop; other site 326424005362 Magnesium ion binding site [ion binding]; other site 326424005363 AAA ATPase domain; Region: AAA_16; pfam13191 326424005364 NACHT domain; Region: NACHT; pfam05729 326424005365 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424005366 Tetratricopeptide repeat; Region: TPR_10; pfam13374 326424005367 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424005368 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424005369 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424005370 HEXXH motif domain; Region: mod_HExxH; TIGR04267 326424005371 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 326424005372 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 326424005373 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 326424005374 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 326424005375 DNA binding residues [nucleotide binding] 326424005376 putative dimer interface [polypeptide binding]; other site 326424005377 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326424005378 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326424005379 active site 326424005380 catalytic tetrad [active] 326424005381 Ycf27; Reviewed; Region: orf27; CHL00148 326424005382 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424005383 active site 326424005384 phosphorylation site [posttranslational modification] 326424005385 intermolecular recognition site; other site 326424005386 dimerization interface [polypeptide binding]; other site 326424005387 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326424005388 DNA binding site [nucleotide binding] 326424005389 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 326424005390 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 326424005391 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 326424005392 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 326424005393 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 326424005394 Precorrin-8X methylmutase; Region: CbiC; pfam02570 326424005395 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 326424005396 active site 326424005397 SAM binding site [chemical binding]; other site 326424005398 homodimer interface [polypeptide binding]; other site 326424005399 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 326424005400 active site 326424005401 homodimer interface [polypeptide binding]; other site 326424005402 SAM binding site [chemical binding]; other site 326424005403 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 326424005404 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 326424005405 active site 326424005406 SAM binding site [chemical binding]; other site 326424005407 homodimer interface [polypeptide binding]; other site 326424005408 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 326424005409 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 326424005410 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 326424005411 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326424005412 Walker A motif; other site 326424005413 ATP binding site [chemical binding]; other site 326424005414 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 326424005415 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 326424005416 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 326424005417 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 326424005418 ATP-grasp domain; Region: ATP-grasp_4; cl17255 326424005419 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 326424005420 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 326424005421 carboxyltransferase (CT) interaction site; other site 326424005422 biotinylation site [posttranslational modification]; other site 326424005423 TIR domain; Region: TIR_2; pfam13676 326424005424 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424005425 non-specific DNA binding site [nucleotide binding]; other site 326424005426 salt bridge; other site 326424005427 sequence-specific DNA binding site [nucleotide binding]; other site 326424005428 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424005429 Tetratricopeptide repeat; Region: TPR_10; pfam13374 326424005430 Tetratricopeptide repeat; Region: TPR_10; pfam13374 326424005431 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424005432 Tetratricopeptide repeat; Region: TPR_10; pfam13374 326424005433 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 326424005434 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 326424005435 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 326424005436 substrate binding site [chemical binding]; other site 326424005437 ATP binding site [chemical binding]; other site 326424005438 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 326424005439 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 326424005440 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 326424005441 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 326424005442 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 326424005443 nudix motif; other site 326424005444 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 326424005445 TrkA-N domain; Region: TrkA_N; pfam02254 326424005446 Ion channel; Region: Ion_trans_2; pfam07885 326424005447 TrkA-N domain; Region: TrkA_N; pfam02254 326424005448 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326424005449 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424005450 non-specific DNA binding site [nucleotide binding]; other site 326424005451 salt bridge; other site 326424005452 sequence-specific DNA binding site [nucleotide binding]; other site 326424005453 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 326424005454 Domain of unknown function (DUF955); Region: DUF955; pfam06114 326424005455 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 326424005456 isocitrate lyase; Provisional; Region: PRK15063 326424005457 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 326424005458 tetramer interface [polypeptide binding]; other site 326424005459 active site 326424005460 Mg2+/Mn2+ binding site [ion binding]; other site 326424005461 malate synthase A; Region: malate_syn_A; TIGR01344 326424005462 malate synthase; Validated; Region: PRK09255 326424005463 active site 326424005464 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 326424005465 AMP-binding enzyme; Region: AMP-binding; pfam00501 326424005466 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424005467 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 326424005468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424005469 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 326424005470 putative substrate translocation pore; other site 326424005471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424005472 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 326424005473 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424005474 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424005475 active site 326424005476 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 326424005477 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 326424005478 AAA domain; Region: AAA_17; pfam13207 326424005479 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 326424005480 dimer interface [polypeptide binding]; other site 326424005481 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424005482 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 326424005483 putative substrate translocation pore; other site 326424005484 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 326424005485 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 326424005486 active site 326424005487 FMN binding site [chemical binding]; other site 326424005488 substrate binding site [chemical binding]; other site 326424005489 3Fe-4S cluster binding site [ion binding]; other site 326424005490 similar to hypothetical protein; Evidence 5 : No homology to any previously reported sequences 326424005491 Condensation domain; Region: Condensation; pfam00668 326424005492 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 326424005493 N-acetyl-D-glucosamine binding site [chemical binding]; other site 326424005494 Citrate synthase; Region: Citrate_synt; pfam00285 326424005495 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 326424005496 oxalacetate binding site [chemical binding]; other site 326424005497 citrylCoA binding site [chemical binding]; other site 326424005498 coenzyme A binding site [chemical binding]; other site 326424005499 catalytic triad [active] 326424005500 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 326424005501 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 326424005502 DNA binding residues [nucleotide binding] 326424005503 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 326424005504 Citrate synthase; Region: Citrate_synt; pfam00285 326424005505 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 326424005506 oxalacetate binding site [chemical binding]; other site 326424005507 citrylCoA binding site [chemical binding]; other site 326424005508 coenzyme A binding site [chemical binding]; other site 326424005509 catalytic triad [active] 326424005510 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 326424005511 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 326424005512 substrate binding pocket [chemical binding]; other site 326424005513 membrane-bound complex binding site; other site 326424005514 hinge residues; other site 326424005515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424005516 dimer interface [polypeptide binding]; other site 326424005517 conserved gate region; other site 326424005518 ABC-ATPase subunit interface; other site 326424005519 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 326424005520 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424005521 Walker A/P-loop; other site 326424005522 ATP binding site [chemical binding]; other site 326424005523 Q-loop/lid; other site 326424005524 ABC transporter signature motif; other site 326424005525 Walker B; other site 326424005526 D-loop; other site 326424005527 H-loop/switch region; other site 326424005528 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424005529 salt bridge; other site 326424005530 non-specific DNA binding site [nucleotide binding]; other site 326424005531 sequence-specific DNA binding site [nucleotide binding]; other site 326424005532 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326424005533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424005534 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 326424005535 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 326424005536 Putative [NiFe] hydrogenase-specific C-terminal protease. Sequence comparison shows similarity to hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). Maturation of [FeNi] hydrogenases includes formation of...; Region: H2MP_like-1; cd06068 326424005537 nickel binding site [ion binding]; other site 326424005538 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 326424005539 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 326424005540 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 326424005541 NifU-like domain; Region: NifU; cl00484 326424005542 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 326424005543 Acylphosphatase; Region: Acylphosphatase; pfam00708 326424005544 HypF finger; Region: zf-HYPF; pfam07503 326424005545 HypF finger; Region: zf-HYPF; pfam07503 326424005546 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 326424005547 HupF/HypC family; Region: HupF_HypC; pfam01455 326424005548 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 326424005549 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 326424005550 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 326424005551 dimerization interface [polypeptide binding]; other site 326424005552 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 326424005553 ATP binding site [chemical binding]; other site 326424005554 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 326424005555 DNA-binding site [nucleotide binding]; DNA binding site 326424005556 RNA-binding motif; other site 326424005557 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 326424005558 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 326424005559 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 326424005560 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233 326424005561 putative active site [active] 326424005562 Zn binding site [ion binding]; other site 326424005563 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 326424005564 substrate binding site [chemical binding]; other site 326424005565 nucleotide binding site [chemical binding]; other site 326424005566 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 326424005567 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 326424005568 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424005569 NAD(P) binding site [chemical binding]; other site 326424005570 active site 326424005571 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 326424005572 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 326424005573 Walker A/P-loop; other site 326424005574 ATP binding site [chemical binding]; other site 326424005575 Q-loop/lid; other site 326424005576 ABC transporter signature motif; other site 326424005577 Walker B; other site 326424005578 D-loop; other site 326424005579 H-loop/switch region; other site 326424005580 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 326424005581 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 326424005582 ABC-ATPase subunit interface; other site 326424005583 dimer interface [polypeptide binding]; other site 326424005584 putative PBP binding regions; other site 326424005585 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 326424005586 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 326424005587 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 326424005588 putative ligand binding residues [chemical binding]; other site 326424005589 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 326424005590 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 326424005591 active site 326424005592 catalytic residues [active] 326424005593 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 326424005594 putative FMN binding site [chemical binding]; other site 326424005595 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 326424005596 FMN binding site [chemical binding]; other site 326424005597 Nitroreductase family; Region: Nitroreductase; pfam00881 326424005598 dimer interface [polypeptide binding]; other site 326424005599 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 326424005600 active site 326424005601 metal binding site [ion binding]; metal-binding site 326424005602 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 326424005603 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 326424005604 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 326424005605 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 326424005606 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424005607 active site 326424005608 phosphorylation site [posttranslational modification] 326424005609 intermolecular recognition site; other site 326424005610 dimerization interface [polypeptide binding]; other site 326424005611 GAF domain; Region: GAF; pfam01590 326424005612 GAF domain; Region: GAF_2; pfam13185 326424005613 PAS domain S-box; Region: sensory_box; TIGR00229 326424005614 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 326424005615 putative active site [active] 326424005616 heme pocket [chemical binding]; other site 326424005617 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 326424005618 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 326424005619 putative active site [active] 326424005620 heme pocket [chemical binding]; other site 326424005621 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326424005622 dimer interface [polypeptide binding]; other site 326424005623 phosphorylation site [posttranslational modification] 326424005624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424005625 ATP binding site [chemical binding]; other site 326424005626 Mg2+ binding site [ion binding]; other site 326424005627 G-X-G motif; other site 326424005628 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 326424005629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424005630 active site 326424005631 phosphorylation site [posttranslational modification] 326424005632 intermolecular recognition site; other site 326424005633 dimerization interface [polypeptide binding]; other site 326424005634 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 326424005635 enoyl-CoA hydratase; Provisional; Region: PRK08252 326424005636 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424005637 substrate binding site [chemical binding]; other site 326424005638 oxyanion hole (OAH) forming residues; other site 326424005639 trimer interface [polypeptide binding]; other site 326424005640 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 326424005641 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 326424005642 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 326424005643 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 326424005644 putative molybdopterin cofactor binding site [chemical binding]; other site 326424005645 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 326424005646 putative molybdopterin cofactor binding site; other site 326424005647 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 326424005648 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 326424005649 putative active site; other site 326424005650 putative metal binding residues [ion binding]; other site 326424005651 signature motif; other site 326424005652 putative triphosphate binding site [ion binding]; other site 326424005653 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 326424005654 Flavodoxin domain; Region: Flavodoxin_5; cl17428 326424005655 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424005656 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 326424005657 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424005658 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424005659 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 326424005660 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424005661 Tannase and feruloyl esterase; Region: Tannase; pfam07519 326424005662 Caspase domain; Region: Peptidase_C14; pfam00656 326424005663 Part of AAA domain; Region: AAA_19; pfam13245 326424005664 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 326424005665 AAA domain; Region: AAA_12; pfam13087 326424005666 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 326424005667 classical (c) SDRs; Region: SDR_c; cd05233 326424005668 NAD(P) binding site [chemical binding]; other site 326424005669 active site 326424005670 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424005671 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424005672 hypothetical protein; Provisional; Region: PRK07208 326424005673 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 326424005674 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424005675 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424005676 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 326424005677 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 326424005678 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 326424005679 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 326424005680 nudix motif; other site 326424005681 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 326424005682 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 326424005683 putative ligand binding site [chemical binding]; other site 326424005684 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424005685 NAD(P) binding site [chemical binding]; other site 326424005686 active site 326424005687 MarR family; Region: MarR_2; pfam12802 326424005688 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 326424005689 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 326424005690 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 326424005691 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 326424005692 Protein of unknown function, DUF488; Region: DUF488; pfam04343 326424005693 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 326424005694 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 326424005695 apolar tunnel; other site 326424005696 heme binding site [chemical binding]; other site 326424005697 dimerization interface [polypeptide binding]; other site 326424005698 Predicted transcriptional regulators [Transcription]; Region: COG1733 326424005699 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 326424005700 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 326424005701 apolar tunnel; other site 326424005702 heme binding site [chemical binding]; other site 326424005703 dimerization interface [polypeptide binding]; other site 326424005704 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 326424005705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424005706 S-adenosylmethionine binding site [chemical binding]; other site 326424005707 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 326424005708 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 326424005709 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 326424005710 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424005711 Walker A/P-loop; other site 326424005712 ATP binding site [chemical binding]; other site 326424005713 Q-loop/lid; other site 326424005714 ABC transporter signature motif; other site 326424005715 Walker B; other site 326424005716 D-loop; other site 326424005717 H-loop/switch region; other site 326424005718 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 326424005719 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326424005720 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424005721 Walker A/P-loop; other site 326424005722 ATP binding site [chemical binding]; other site 326424005723 Q-loop/lid; other site 326424005724 ABC transporter signature motif; other site 326424005725 Walker B; other site 326424005726 D-loop; other site 326424005727 H-loop/switch region; other site 326424005728 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 326424005729 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 326424005730 dimer interface [polypeptide binding]; other site 326424005731 active site 326424005732 non-prolyl cis peptide bond; other site 326424005733 insertion regions; other site 326424005734 Predicted ATPase [General function prediction only]; Region: COG3911 326424005735 AAA domain; Region: AAA_28; pfam13521 326424005736 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424005737 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 326424005738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424005739 S-adenosylmethionine binding site [chemical binding]; other site 326424005740 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 326424005741 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 326424005742 NAD binding site [chemical binding]; other site 326424005743 substrate binding site [chemical binding]; other site 326424005744 catalytic Zn binding site [ion binding]; other site 326424005745 structural Zn binding site [ion binding]; other site 326424005746 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 326424005747 Zn2+ binding site [ion binding]; other site 326424005748 Mg2+ binding site [ion binding]; other site 326424005749 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 326424005750 PAS domain; Region: PAS_9; pfam13426 326424005751 putative active site [active] 326424005752 heme pocket [chemical binding]; other site 326424005753 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 326424005754 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 326424005755 metal binding site [ion binding]; metal-binding site 326424005756 active site 326424005757 I-site; other site 326424005758 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 326424005759 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 326424005760 Active site cavity [active] 326424005761 catalytic acid [active] 326424005762 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 326424005763 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424005764 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 326424005765 Integrase core domain; Region: rve; pfam00665 326424005766 DDE domain; Region: DDE_Tnp_IS240; pfam13610 326424005767 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 326424005768 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424005769 ATP binding site [chemical binding]; other site 326424005770 Mg2+ binding site [ion binding]; other site 326424005771 G-X-G motif; other site 326424005772 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 326424005773 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326424005774 active site 326424005775 metal binding site [ion binding]; metal-binding site 326424005776 SnoaL-like domain; Region: SnoaL_2; pfam12680 326424005777 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 326424005778 putative hydrophobic ligand binding site [chemical binding]; other site 326424005779 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326424005780 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424005781 non-specific DNA binding site [nucleotide binding]; other site 326424005782 salt bridge; other site 326424005783 sequence-specific DNA binding site [nucleotide binding]; other site 326424005784 Predicted ATPase [General function prediction only]; Region: COG3903 326424005785 classical (c) SDRs; Region: SDR_c; cd05233 326424005786 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 326424005787 NAD(P) binding site [chemical binding]; other site 326424005788 active site 326424005789 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 326424005790 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 326424005791 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424005792 NAD(P) binding site [chemical binding]; other site 326424005793 active site 326424005794 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 326424005795 CoA-transferase family III; Region: CoA_transf_3; pfam02515 326424005796 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 326424005797 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 326424005798 DUF35 OB-fold domain; Region: DUF35; pfam01796 326424005799 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 326424005800 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 326424005801 active site 326424005802 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 326424005803 active site 326424005804 catalytic site [active] 326424005805 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 326424005806 active site 2 [active] 326424005807 active site 1 [active] 326424005808 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424005809 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 326424005810 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424005811 active site 326424005812 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 326424005813 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424005814 FAD binding site [chemical binding]; other site 326424005815 substrate binding site [chemical binding]; other site 326424005816 catalytic base [active] 326424005817 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 326424005818 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 326424005819 dimer interface [polypeptide binding]; other site 326424005820 active site 326424005821 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 326424005822 putative hydrophobic ligand binding site [chemical binding]; other site 326424005823 protein interface [polypeptide binding]; other site 326424005824 gate; other site 326424005825 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424005826 acyl-activating enzyme (AAE) consensus motif; other site 326424005827 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 326424005828 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 326424005829 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 326424005830 classical (c) SDRs; Region: SDR_c; cd05233 326424005831 NAD(P) binding site [chemical binding]; other site 326424005832 active site 326424005833 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424005834 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424005835 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 326424005836 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424005837 Domain of unknown function DUF59; Region: DUF59; cl00941 326424005838 Amidohydrolase; Region: Amidohydro_2; pfam04909 326424005839 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 326424005840 classical (c) SDRs; Region: SDR_c; cd05233 326424005841 NAD(P) binding site [chemical binding]; other site 326424005842 active site 326424005843 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 326424005844 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 326424005845 TM-ABC transporter signature motif; other site 326424005846 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 326424005847 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424005848 Walker A/P-loop; other site 326424005849 ATP binding site [chemical binding]; other site 326424005850 Q-loop/lid; other site 326424005851 ABC transporter signature motif; other site 326424005852 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424005853 H-loop/switch region; other site 326424005854 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 326424005855 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 326424005856 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 326424005857 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 326424005858 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 326424005859 HTH-like domain; Region: HTH_21; pfam13276 326424005860 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 326424005861 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 326424005862 NB-ARC domain; Region: NB-ARC; pfam00931 326424005863 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424005864 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424005865 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 326424005866 Putative FMN-binding domain; Region: FMN_bind_2; cl17803 326424005867 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 326424005868 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 326424005869 NAD(P) binding site [chemical binding]; other site 326424005870 MbtH-like protein; Region: MbtH; pfam03621 326424005871 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 326424005872 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 326424005873 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 326424005874 acyl-activating enzyme (AAE) consensus motif; other site 326424005875 AMP binding site [chemical binding]; other site 326424005876 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326424005877 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 326424005878 Condensation domain; Region: Condensation; pfam00668 326424005879 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326424005880 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 326424005881 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 326424005882 acyl-activating enzyme (AAE) consensus motif; other site 326424005883 AMP binding site [chemical binding]; other site 326424005884 Condensation domain; Region: Condensation; pfam00668 326424005885 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 326424005886 Condensation domain; Region: Condensation; pfam00668 326424005887 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326424005888 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 326424005889 acyl-activating enzyme (AAE) consensus motif; other site 326424005890 AMP binding site [chemical binding]; other site 326424005891 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326424005892 Condensation domain; Region: Condensation; pfam00668 326424005893 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326424005894 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 326424005895 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 326424005896 acyl-activating enzyme (AAE) consensus motif; other site 326424005897 AMP binding site [chemical binding]; other site 326424005898 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326424005899 Condensation domain; Region: Condensation; pfam00668 326424005900 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 326424005901 Condensation domain; Region: Condensation; pfam00668 326424005902 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326424005903 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 326424005904 acyl-activating enzyme (AAE) consensus motif; other site 326424005905 AMP binding site [chemical binding]; other site 326424005906 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326424005907 Condensation domain; Region: Condensation; pfam00668 326424005908 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326424005909 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 326424005910 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 326424005911 acyl-activating enzyme (AAE) consensus motif; other site 326424005912 AMP binding site [chemical binding]; other site 326424005913 Methyltransferase domain; Region: Methyltransf_31; pfam13847 326424005914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424005915 S-adenosylmethionine binding site [chemical binding]; other site 326424005916 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424005917 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326424005918 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 326424005919 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 326424005920 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424005921 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 326424005922 Walker A/P-loop; other site 326424005923 ATP binding site [chemical binding]; other site 326424005924 Q-loop/lid; other site 326424005925 ABC transporter signature motif; other site 326424005926 Walker B; other site 326424005927 D-loop; other site 326424005928 H-loop/switch region; other site 326424005929 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 326424005930 ABC-2 type transporter; Region: ABC2_membrane; cl17235 326424005931 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 326424005932 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 326424005933 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326424005934 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 326424005935 Cytochrome P450; Region: p450; cl12078 326424005936 Thioesterase domain; Region: Thioesterase; pfam00975 326424005937 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326424005938 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326424005939 active site 326424005940 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 326424005941 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 326424005942 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326424005943 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 326424005944 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326424005945 active site 326424005946 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 326424005947 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326424005948 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 326424005949 putative NADP binding site [chemical binding]; other site 326424005950 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326424005951 active site 326424005952 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326424005953 Erythronolide synthase docking; Region: Docking; pfam08990 326424005954 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 326424005955 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326424005956 active site 326424005957 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 326424005958 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326424005959 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 326424005960 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 326424005961 Enoylreductase; Region: PKS_ER; smart00829 326424005962 NAD(P) binding site [chemical binding]; other site 326424005963 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 326424005964 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326424005965 putative NADP binding site [chemical binding]; other site 326424005966 active site 326424005967 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326424005968 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326424005969 3-oxoacyl-acyl carrier protein synthase; Provisional; Region: PTZ00050 326424005970 active site 326424005971 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 326424005972 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 326424005973 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326424005974 Condensation domain; Region: Condensation; pfam00668 326424005975 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 326424005976 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 326424005977 acyl-activating enzyme (AAE) consensus motif; other site 326424005978 AMP binding site [chemical binding]; other site 326424005979 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326424005980 hypothetical protein; Provisional; Region: PRK06834 326424005981 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 326424005982 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 326424005983 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 326424005984 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 326424005985 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 326424005986 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 326424005987 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 326424005988 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 326424005989 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 326424005990 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 326424005991 Predicted transcriptional regulators [Transcription]; Region: COG1695 326424005992 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 326424005993 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 326424005994 Recombinase; Region: Recombinase; pfam07508 326424005995 Evidence 7 : Gene remnant 326424005996 Evidence 7 : Gene remnant 326424005997 Evidence 7 : Gene remnant 326424005998 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 326424005999 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 326424006000 active site 326424006001 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424006002 S-adenosylmethionine binding site [chemical binding]; other site 326424006003 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 326424006004 extended (e) SDRs; Region: SDR_e; cd08946 326424006005 active site 326424006006 radical SAM enzyme, rSAM/lipoprotein system; Region: rSAM_w_lipo; TIGR04133 326424006007 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326424006008 FeS/SAM binding site; other site 326424006009 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 326424006010 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424006011 NAD(P) binding site [chemical binding]; other site 326424006012 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326424006013 active site 326424006014 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 326424006015 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 326424006016 active site 326424006017 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 326424006018 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424006019 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326424006020 DNA binding residues [nucleotide binding] 326424006021 dimerization interface [polypeptide binding]; other site 326424006022 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424006023 Epoxide hydrolase N terminus; Region: EHN; pfam06441 326424006024 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 326424006025 oxidoreductase; Provisional; Region: PRK12742 326424006026 Transcriptional regulators [Transcription]; Region: MarR; COG1846 326424006027 MarR family; Region: MarR; pfam01047 326424006028 Transposase; Region: HTH_Tnp_1; cl17663 326424006029 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424006030 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424006031 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 326424006032 Clp amino terminal domain; Region: Clp_N; pfam02861 326424006033 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326424006034 Walker A motif; other site 326424006035 ATP binding site [chemical binding]; other site 326424006036 Walker B motif; other site 326424006037 arginine finger; other site 326424006038 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326424006039 Walker A motif; other site 326424006040 ATP binding site [chemical binding]; other site 326424006041 Walker B motif; other site 326424006042 arginine finger; other site 326424006043 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 326424006044 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 326424006045 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 326424006046 HSP70 interaction site [polypeptide binding]; other site 326424006047 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 326424006048 substrate binding site [polypeptide binding]; other site 326424006049 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 326424006050 dimer interface [polypeptide binding]; other site 326424006051 GrpE; Region: GrpE; pfam01025 326424006052 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 326424006053 dimer interface [polypeptide binding]; other site 326424006054 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 326424006055 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 326424006056 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 326424006057 nucleotide binding site [chemical binding]; other site 326424006058 Domain of unknown function (DUF1931); Region: DUF1931; pfam09123 326424006059 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 326424006060 Switch II region; other site 326424006061 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 326424006062 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 326424006063 ligand binding site [chemical binding]; other site 326424006064 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 326424006065 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 326424006066 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326424006067 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 326424006068 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 326424006069 acyl-activating enzyme (AAE) consensus motif; other site 326424006070 putative AMP binding site [chemical binding]; other site 326424006071 putative active site [active] 326424006072 putative CoA binding site [chemical binding]; other site 326424006073 CoA-transferase family III; Region: CoA_transf_3; pfam02515 326424006074 CoA-transferase family III; Region: CoA_transf_3; pfam02515 326424006075 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 326424006076 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 326424006077 formyl-CoA transferase; Region: oxalate_frc; TIGR03253 326424006078 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 326424006079 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 326424006080 acyl-activating enzyme (AAE) consensus motif; other site 326424006081 putative AMP binding site [chemical binding]; other site 326424006082 putative active site [active] 326424006083 putative CoA binding site [chemical binding]; other site 326424006084 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 326424006085 putative acyltransferase; Provisional; Region: PRK05790 326424006086 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 326424006087 dimer interface [polypeptide binding]; other site 326424006088 active site 326424006089 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 326424006090 Beta-lactamase; Region: Beta-lactamase; pfam00144 326424006091 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424006092 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441 326424006093 active site 326424006094 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424006095 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424006096 active site 326424006097 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 326424006098 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 326424006099 Walker A/P-loop; other site 326424006100 ATP binding site [chemical binding]; other site 326424006101 Q-loop/lid; other site 326424006102 ABC transporter signature motif; other site 326424006103 Walker B; other site 326424006104 D-loop; other site 326424006105 H-loop/switch region; other site 326424006106 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 326424006107 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 326424006108 TM-ABC transporter signature motif; other site 326424006109 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 326424006110 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 326424006111 TM-ABC transporter signature motif; other site 326424006112 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 326424006113 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 326424006114 Walker A/P-loop; other site 326424006115 ATP binding site [chemical binding]; other site 326424006116 Q-loop/lid; other site 326424006117 ABC transporter signature motif; other site 326424006118 Walker B; other site 326424006119 D-loop; other site 326424006120 H-loop/switch region; other site 326424006121 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 326424006122 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 326424006123 putative ligand binding site [chemical binding]; other site 326424006124 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424006125 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424006126 active site 326424006127 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424006128 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424006129 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424006130 enoyl-CoA hydratase; Provisional; Region: PRK06688 326424006131 substrate binding site [chemical binding]; other site 326424006132 oxyanion hole (OAH) forming residues; other site 326424006133 trimer interface [polypeptide binding]; other site 326424006134 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 326424006135 DUF35 OB-fold domain; Region: DUF35; pfam01796 326424006136 lipid-transfer protein; Provisional; Region: PRK08256 326424006137 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 326424006138 active site 326424006139 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 326424006140 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424006141 AMP binding site [chemical binding]; other site 326424006142 active site 326424006143 acyl-activating enzyme (AAE) consensus motif; other site 326424006144 CoA binding site [chemical binding]; other site 326424006145 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 326424006146 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 326424006147 NAD binding site [chemical binding]; other site 326424006148 catalytic residues [active] 326424006149 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 326424006150 classical (c) SDRs; Region: SDR_c; cd05233 326424006151 NAD(P) binding site [chemical binding]; other site 326424006152 active site 326424006153 Amidohydrolase; Region: Amidohydro_2; pfam04909 326424006154 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 326424006155 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 326424006156 active site 326424006157 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 326424006158 DUF35 OB-fold domain; Region: DUF35; pfam01796 326424006159 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 326424006160 CoA-transferase family III; Region: CoA_transf_3; pfam02515 326424006161 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 326424006162 CoA-transferase family III; Region: CoA_transf_3; pfam02515 326424006163 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 326424006164 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 326424006165 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 326424006166 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424006167 substrate binding site [chemical binding]; other site 326424006168 oxyanion hole (OAH) forming residues; other site 326424006169 trimer interface [polypeptide binding]; other site 326424006170 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 326424006171 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424006172 NAD(P) binding site [chemical binding]; other site 326424006173 active site 326424006174 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 326424006175 active site 326424006176 NTP binding site [chemical binding]; other site 326424006177 metal binding triad [ion binding]; metal-binding site 326424006178 antibiotic binding site [chemical binding]; other site 326424006179 AAA-like domain; Region: AAA_10; pfam12846 326424006180 Domain of unknown function DUF87; Region: DUF87; pfam01935 326424006181 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 326424006182 Nuclease-related domain; Region: NERD; pfam08378 326424006183 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 326424006184 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 326424006185 active site 326424006186 ATP binding site [chemical binding]; other site 326424006187 substrate binding site [chemical binding]; other site 326424006188 activation loop (A-loop); other site 326424006189 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424006190 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424006191 active site 326424006192 ATP binding site [chemical binding]; other site 326424006193 substrate binding site [chemical binding]; other site 326424006194 activation loop (A-loop); other site 326424006195 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 326424006196 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 326424006197 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 326424006198 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 326424006199 Transposase; Region: DEDD_Tnp_IS110; pfam01548 326424006200 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 326424006201 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 326424006202 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 326424006203 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 326424006204 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 326424006205 DNA binding site [nucleotide binding] 326424006206 active site 326424006207 Int/Topo IB signature motif; other site 326424006208 catalytic residues [active] 326424006209 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 326424006210 active site 326424006211 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 326424006212 amidase catalytic site [active] 326424006213 Zn binding residues [ion binding]; other site 326424006214 substrate binding site [chemical binding]; other site 326424006215 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 326424006216 active site 326424006217 catalytic residues [active] 326424006218 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 326424006219 peptidase domain interface [polypeptide binding]; other site 326424006220 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 326424006221 active site 326424006222 catalytic triad [active] 326424006223 calcium binding site [ion binding]; other site 326424006224 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 326424006225 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 326424006226 N-acetyl-D-glucosamine binding site [chemical binding]; other site 326424006227 catalytic residue [active] 326424006228 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 326424006229 active site 326424006230 catalytic triad [active] 326424006231 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 326424006232 hypothetical protein; Provisional; Region: PRK07740 326424006233 cell division protein ZipA; Provisional; Region: PRK03427 326424006234 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 326424006235 methyltransferase, FxLD system; Region: methyltran_FxLD; TIGR04364 326424006236 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424006237 S-adenosylmethionine binding site [chemical binding]; other site 326424006238 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 326424006239 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 326424006240 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 326424006241 active site 326424006242 zinc binding site [ion binding]; other site 326424006243 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 326424006244 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 326424006245 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 326424006246 methyltransferase, FxLD system; Region: methyltran_FxLD; TIGR04364 326424006247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424006248 S-adenosylmethionine binding site [chemical binding]; other site 326424006249 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326424006250 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424006251 non-specific DNA binding site [nucleotide binding]; other site 326424006252 salt bridge; other site 326424006253 sequence-specific DNA binding site [nucleotide binding]; other site 326424006254 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 326424006255 putative active site [active] 326424006256 putative metal binding residues [ion binding]; other site 326424006257 signature motif; other site 326424006258 putative triphosphate binding site [ion binding]; other site 326424006259 dimer interface [polypeptide binding]; other site 326424006260 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 326424006261 putative catalytic site [active] 326424006262 putative phosphate binding site [ion binding]; other site 326424006263 putative metal binding site [ion binding]; other site 326424006264 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 326424006265 TMP-binding site; other site 326424006266 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 326424006267 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326424006268 FeS/SAM binding site; other site 326424006269 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 326424006270 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326424006271 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326424006272 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 326424006273 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 326424006274 active site 326424006275 catalytic site [active] 326424006276 substrate binding site [chemical binding]; other site 326424006277 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 326424006278 hypothetical protein; Provisional; Region: PRK08317 326424006279 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 326424006280 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 326424006281 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 326424006282 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 326424006283 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 326424006284 ligand binding site [chemical binding]; other site 326424006285 flexible hinge region; other site 326424006286 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 326424006287 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 326424006288 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 326424006289 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 326424006290 ligand binding site [chemical binding]; other site 326424006291 flexible hinge region; other site 326424006292 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 326424006293 putative switch regulator; other site 326424006294 non-specific DNA interactions [nucleotide binding]; other site 326424006295 DNA binding site [nucleotide binding] 326424006296 sequence specific DNA binding site [nucleotide binding]; other site 326424006297 putative cAMP binding site [chemical binding]; other site 326424006298 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 326424006299 putative active site pocket [active] 326424006300 4-fold oligomerization interface [polypeptide binding]; other site 326424006301 metal binding residues [ion binding]; metal-binding site 326424006302 3-fold/trimer interface [polypeptide binding]; other site 326424006303 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 326424006304 putative metal binding site [ion binding]; other site 326424006305 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326424006306 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424006307 non-specific DNA binding site [nucleotide binding]; other site 326424006308 salt bridge; other site 326424006309 sequence-specific DNA binding site [nucleotide binding]; other site 326424006310 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 326424006311 active site 326424006312 4Fe-4S single cluster domain; Region: Fer4_14; pfam13394 326424006313 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326424006314 FeS/SAM binding site; other site 326424006315 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 326424006316 active site 326424006317 Oxygenase domain of the 2OGFeDO superfamily; Region: Tet_JBP; pfam12851 326424006318 phage/plasmid-like protein TIGR03299; Region: LGT_TIGR03299 326424006319 Domain of unknown function (DUF3560); Region: DUF3560; pfam12083 326424006320 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 326424006321 DNA binding residues [nucleotide binding] 326424006322 MarR family; Region: MarR_2; cl17246 326424006323 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 326424006324 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424006325 non-specific DNA binding site [nucleotide binding]; other site 326424006326 salt bridge; other site 326424006327 sequence-specific DNA binding site [nucleotide binding]; other site 326424006328 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 326424006329 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 326424006330 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 326424006331 active site 326424006332 DNA binding site [nucleotide binding] 326424006333 Int/Topo IB signature motif; other site 326424006334 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424006335 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424006336 active site 326424006337 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424006338 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424006339 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 326424006340 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 326424006341 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 326424006342 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 326424006343 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 326424006344 UGMP family protein; Validated; Region: PRK09604 326424006345 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 326424006346 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 326424006347 metal binding site 2 [ion binding]; metal-binding site 326424006348 putative DNA binding helix; other site 326424006349 metal binding site 1 [ion binding]; metal-binding site 326424006350 structural Zn2+ binding site [ion binding]; other site 326424006351 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 326424006352 active site 326424006353 catalytic residues [active] 326424006354 metal binding site [ion binding]; metal-binding site 326424006355 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 326424006356 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424006357 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 326424006358 FAD binding domain; Region: FAD_binding_4; pfam01565 326424006359 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 326424006360 active site 326424006361 SAM binding site [chemical binding]; other site 326424006362 homodimer interface [polypeptide binding]; other site 326424006363 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 326424006364 active site clefts [active] 326424006365 zinc binding site [ion binding]; other site 326424006366 dimer interface [polypeptide binding]; other site 326424006367 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 326424006368 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 326424006369 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 326424006370 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424006371 substrate binding site [chemical binding]; other site 326424006372 oxyanion hole (OAH) forming residues; other site 326424006373 trimer interface [polypeptide binding]; other site 326424006374 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 326424006375 Domain of unknown function (DUF222); Region: DUF222; pfam02720 326424006376 Domain of unknown function (DUF397); Region: DUF397; pfam04149 326424006377 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 326424006378 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 326424006379 catalytic residues [active] 326424006380 catalytic nucleophile [active] 326424006381 Recombinase; Region: Recombinase; pfam07508 326424006382 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 326424006383 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 326424006384 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326424006385 Walker A/P-loop; other site 326424006386 ATP binding site [chemical binding]; other site 326424006387 Q-loop/lid; other site 326424006388 ABC transporter signature motif; other site 326424006389 Walker B; other site 326424006390 D-loop; other site 326424006391 H-loop/switch region; other site 326424006392 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 326424006393 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 326424006394 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326424006395 Walker A/P-loop; other site 326424006396 ATP binding site [chemical binding]; other site 326424006397 Q-loop/lid; other site 326424006398 ABC transporter signature motif; other site 326424006399 Walker B; other site 326424006400 D-loop; other site 326424006401 H-loop/switch region; other site 326424006402 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 326424006403 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 326424006404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424006405 dimer interface [polypeptide binding]; other site 326424006406 conserved gate region; other site 326424006407 putative PBP binding loops; other site 326424006408 ABC-ATPase subunit interface; other site 326424006409 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 326424006410 peptide binding site [polypeptide binding]; other site 326424006411 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 326424006412 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 326424006413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424006414 dimer interface [polypeptide binding]; other site 326424006415 conserved gate region; other site 326424006416 putative PBP binding loops; other site 326424006417 ABC-ATPase subunit interface; other site 326424006418 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 326424006419 putative hydrophobic ligand binding site [chemical binding]; other site 326424006420 hypothetical protein; Provisional; Region: PRK07906 326424006421 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 326424006422 putative metal binding site [ion binding]; other site 326424006423 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 326424006424 DUF35 OB-fold domain; Region: DUF35; pfam01796 326424006425 lipid-transfer protein; Provisional; Region: PRK07855 326424006426 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 326424006427 active site 326424006428 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 326424006429 CoA-transferase family III; Region: CoA_transf_3; pfam02515 326424006430 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 326424006431 CoA-transferase family III; Region: CoA_transf_3; pfam02515 326424006432 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424006433 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424006434 active site 326424006435 Transcriptional regulators [Transcription]; Region: FadR; COG2186 326424006436 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326424006437 DNA-binding site [nucleotide binding]; DNA binding site 326424006438 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424006439 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 326424006440 NAD(P) binding site [chemical binding]; other site 326424006441 active site 326424006442 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424006443 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424006444 active site 326424006445 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 326424006446 active site 326424006447 catalytic site [active] 326424006448 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 326424006449 active site 2 [active] 326424006450 active site 1 [active] 326424006451 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 326424006452 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424006453 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 326424006454 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424006455 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424006456 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424006457 active site 326424006458 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424006459 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 326424006460 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 326424006461 acyl-activating enzyme (AAE) consensus motif; other site 326424006462 acyl-activating enzyme (AAE) consensus motif; other site 326424006463 putative AMP binding site [chemical binding]; other site 326424006464 putative active site [active] 326424006465 putative CoA binding site [chemical binding]; other site 326424006466 Amidohydrolase; Region: Amidohydro_2; pfam04909 326424006467 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 326424006468 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 326424006469 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 326424006470 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 326424006471 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 326424006472 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 326424006473 putative ligand binding site [chemical binding]; other site 326424006474 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 326424006475 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 326424006476 Walker A/P-loop; other site 326424006477 ATP binding site [chemical binding]; other site 326424006478 Q-loop/lid; other site 326424006479 ABC transporter signature motif; other site 326424006480 Walker B; other site 326424006481 D-loop; other site 326424006482 H-loop/switch region; other site 326424006483 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 326424006484 TM-ABC transporter signature motif; other site 326424006485 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 326424006486 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 326424006487 TM-ABC transporter signature motif; other site 326424006488 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 326424006489 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 326424006490 Walker A/P-loop; other site 326424006491 ATP binding site [chemical binding]; other site 326424006492 Q-loop/lid; other site 326424006493 ABC transporter signature motif; other site 326424006494 Walker B; other site 326424006495 D-loop; other site 326424006496 H-loop/switch region; other site 326424006497 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 326424006498 hypothetical protein; Provisional; Region: PRK07208 326424006499 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 326424006500 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 326424006501 AAA domain; Region: AAA_30; pfam13604 326424006502 Family description; Region: UvrD_C_2; pfam13538 326424006503 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 326424006504 catalytic core [active] 326424006505 conserved hypothetical protein; Region: TIGR03847 326424006506 conserved hypothetical protein; Region: TIGR03843 326424006507 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 326424006508 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 326424006509 active site 326424006510 HIGH motif; other site 326424006511 nucleotide binding site [chemical binding]; other site 326424006512 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 326424006513 active site 326424006514 KMSKS motif; other site 326424006515 DivIVA protein; Region: DivIVA; pfam05103 326424006516 PAC2 family; Region: PAC2; pfam09754 326424006517 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 326424006518 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 326424006519 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326424006520 motif II; other site 326424006521 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 326424006522 putative active site [active] 326424006523 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 326424006524 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 326424006525 FtsX-like permease family; Region: FtsX; pfam02687 326424006526 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 326424006527 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 326424006528 FtsX-like permease family; Region: FtsX; pfam02687 326424006529 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 326424006530 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 326424006531 Walker A/P-loop; other site 326424006532 ATP binding site [chemical binding]; other site 326424006533 Q-loop/lid; other site 326424006534 ABC transporter signature motif; other site 326424006535 Walker B; other site 326424006536 D-loop; other site 326424006537 H-loop/switch region; other site 326424006538 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 326424006539 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 326424006540 Peptidase family M50; Region: Peptidase_M50; pfam02163 326424006541 active site 326424006542 putative substrate binding region [chemical binding]; other site 326424006543 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 326424006544 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424006545 S-adenosylmethionine binding site [chemical binding]; other site 326424006546 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 326424006547 proteasome ATPase; Region: pup_AAA; TIGR03689 326424006548 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326424006549 Walker A motif; other site 326424006550 ATP binding site [chemical binding]; other site 326424006551 Walker B motif; other site 326424006552 arginine finger; other site 326424006553 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 326424006554 Pup-like protein; Region: Pup; pfam05639 326424006555 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 326424006556 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 326424006557 active site 326424006558 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 326424006559 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 326424006560 active site 326424006561 Dienelactone hydrolase family; Region: DLH; pfam01738 326424006562 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 326424006563 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 326424006564 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 326424006565 WYL domain; Region: WYL; pfam13280 326424006566 Predicted transcriptional regulator [Transcription]; Region: COG2378 326424006567 WYL domain; Region: WYL; pfam13280 326424006568 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 326424006569 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 326424006570 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 326424006571 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326424006572 ATP binding site [chemical binding]; other site 326424006573 putative Mg++ binding site [ion binding]; other site 326424006574 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 326424006575 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326424006576 nucleotide binding region [chemical binding]; other site 326424006577 ATP-binding site [chemical binding]; other site 326424006578 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 326424006579 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 326424006580 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 326424006581 cobyric acid synthase; Provisional; Region: PRK00784 326424006582 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 326424006583 catalytic triad [active] 326424006584 short chain dehydrogenase; Provisional; Region: PRK06197 326424006585 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424006586 NAD(P) binding site [chemical binding]; other site 326424006587 active site 326424006588 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 326424006589 Phosphotransferase enzyme family; Region: APH; pfam01636 326424006590 putative active site [active] 326424006591 putative substrate binding site [chemical binding]; other site 326424006592 ATP binding site [chemical binding]; other site 326424006593 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 326424006594 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 326424006595 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 326424006596 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 326424006597 Cytochrome P450; Region: p450; cl12078 326424006598 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 326424006599 classical (c) SDRs; Region: SDR_c; cd05233 326424006600 NAD(P) binding site [chemical binding]; other site 326424006601 active site 326424006602 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 326424006603 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 326424006604 NAD(P) binding site [chemical binding]; other site 326424006605 catalytic residues [active] 326424006606 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424006607 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424006608 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 326424006609 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 326424006610 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326424006611 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326424006612 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 326424006613 putative dimerization interface [polypeptide binding]; other site 326424006614 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424006615 putative substrate translocation pore; other site 326424006616 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326424006617 Methyltransferase domain; Region: Methyltransf_31; pfam13847 326424006618 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424006619 S-adenosylmethionine binding site [chemical binding]; other site 326424006620 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 326424006621 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 326424006622 active site 326424006623 TDP-binding site; other site 326424006624 glycosyltransferase, MGT family; Region: MGT; TIGR01426 326424006625 acceptor substrate-binding pocket; other site 326424006626 homodimer interface [polypeptide binding]; other site 326424006627 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 326424006628 classical (c) SDRs; Region: SDR_c; cd05233 326424006629 NAD(P) binding site [chemical binding]; other site 326424006630 active site 326424006631 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 326424006632 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326424006633 motif II; other site 326424006634 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326424006635 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 326424006636 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424006637 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 326424006638 Walker A/P-loop; other site 326424006639 ATP binding site [chemical binding]; other site 326424006640 Q-loop/lid; other site 326424006641 ABC transporter signature motif; other site 326424006642 Walker B; other site 326424006643 D-loop; other site 326424006644 H-loop/switch region; other site 326424006645 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 326424006646 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 326424006647 TDP-binding site; other site 326424006648 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 326424006649 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 326424006650 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 326424006651 catalytic site [active] 326424006652 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326424006653 active site 326424006654 Acyl transferase domain; Region: Acyl_transf_1; cl08282 326424006655 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326424006656 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 326424006657 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 326424006658 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 326424006659 phosphate binding site [ion binding]; other site 326424006660 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326424006661 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 326424006662 active site 326424006663 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 326424006664 Acyl transferase domain; Region: Acyl_transf_1; cl08282 326424006665 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 326424006666 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326424006667 putative NADP binding site [chemical binding]; other site 326424006668 active site 326424006669 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424006670 NAD(P) binding site [chemical binding]; other site 326424006671 active site 326424006672 SnoaL-like domain; Region: SnoaL_2; pfam12680 326424006673 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 326424006674 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424006675 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 326424006676 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 326424006677 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 326424006678 catalytic triad [active] 326424006679 conserved cis-peptide bond; other site 326424006680 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 326424006681 active site 326424006682 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 326424006683 catalytic residues [active] 326424006684 catalytic nucleophile [active] 326424006685 Recombinase; Region: Recombinase; pfam07508 326424006686 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 326424006687 Predicted ATPase [General function prediction only]; Region: COG3910 326424006688 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 326424006689 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424006690 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424006691 active site 326424006692 ATP binding site [chemical binding]; other site 326424006693 substrate binding site [chemical binding]; other site 326424006694 activation loop (A-loop); other site 326424006695 FOG: WD40 repeat [General function prediction only]; Region: COG2319 326424006696 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 326424006697 structural tetrad; other site 326424006698 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 326424006699 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424006700 S-adenosylmethionine binding site [chemical binding]; other site 326424006701 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326424006702 Radical SAM superfamily; Region: Radical_SAM; pfam04055 326424006703 FeS/SAM binding site; other site 326424006704 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 326424006705 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 326424006706 active site 326424006707 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 326424006708 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 326424006709 Resolvase, N terminal domain; Region: Resolvase; pfam00239 326424006710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424006711 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424006712 active site 326424006713 phosphorylation site [posttranslational modification] 326424006714 intermolecular recognition site; other site 326424006715 dimerization interface [polypeptide binding]; other site 326424006716 Domain of unknown function (DUF222); Region: DUF222; pfam02720 326424006717 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 326424006718 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 326424006719 DNA binding residues [nucleotide binding] 326424006720 putative dimer interface [polypeptide binding]; other site 326424006721 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326424006722 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326424006723 active site 326424006724 catalytic tetrad [active] 326424006725 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 326424006726 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 326424006727 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 326424006728 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 326424006729 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 326424006730 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 326424006731 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 326424006732 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 326424006733 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 326424006734 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 326424006735 Protein of unknown function (DUF690); Region: DUF690; cl04939 326424006736 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 326424006737 Right handed beta helix region; Region: Beta_helix; pfam13229 326424006738 Right handed beta helix region; Region: Beta_helix; pfam13229 326424006739 stage V sporulation protein K; Region: spore_V_K; TIGR02881 326424006740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326424006741 Walker A motif; other site 326424006742 ATP binding site [chemical binding]; other site 326424006743 Walker B motif; other site 326424006744 arginine finger; other site 326424006745 stage V sporulation protein K; Region: spore_V_K; TIGR02881 326424006746 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326424006747 Walker A motif; other site 326424006748 ATP binding site [chemical binding]; other site 326424006749 Walker B motif; other site 326424006750 arginine finger; other site 326424006751 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 326424006752 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 326424006753 nucleotide binding site [chemical binding]; other site 326424006754 putative NEF/HSP70 interaction site [polypeptide binding]; other site 326424006755 SBD interface [polypeptide binding]; other site 326424006756 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 326424006757 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 326424006758 putative sugar binding sites [chemical binding]; other site 326424006759 Q-X-W motif; other site 326424006760 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 326424006761 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326424006762 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 326424006763 DNA binding residues [nucleotide binding] 326424006764 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 326424006765 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 326424006766 Walker A/P-loop; other site 326424006767 ATP binding site [chemical binding]; other site 326424006768 Q-loop/lid; other site 326424006769 ABC transporter signature motif; other site 326424006770 Walker B; other site 326424006771 D-loop; other site 326424006772 H-loop/switch region; other site 326424006773 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 326424006774 Histidine kinase; Region: HisKA_3; pfam07730 326424006775 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 326424006776 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424006777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424006778 active site 326424006779 phosphorylation site [posttranslational modification] 326424006780 intermolecular recognition site; other site 326424006781 dimerization interface [polypeptide binding]; other site 326424006782 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326424006783 DNA binding residues [nucleotide binding] 326424006784 dimerization interface [polypeptide binding]; other site 326424006785 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 326424006786 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424006787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424006788 active site 326424006789 phosphorylation site [posttranslational modification] 326424006790 intermolecular recognition site; other site 326424006791 dimerization interface [polypeptide binding]; other site 326424006792 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326424006793 DNA binding residues [nucleotide binding] 326424006794 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 326424006795 Histidine kinase; Region: HisKA_3; pfam07730 326424006796 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 326424006797 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 326424006798 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326424006799 active site 326424006800 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 326424006801 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326424006802 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 326424006803 Enoylreductase; Region: PKS_ER; smart00829 326424006804 NAD(P) binding site [chemical binding]; other site 326424006805 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 326424006806 KR domain; Region: KR; pfam08659 326424006807 putative NADP binding site [chemical binding]; other site 326424006808 active site 326424006809 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326424006810 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 326424006811 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 326424006812 active site 326424006813 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 326424006814 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424006815 active site 326424006816 phosphorylation site [posttranslational modification] 326424006817 intermolecular recognition site; other site 326424006818 dimerization interface [polypeptide binding]; other site 326424006819 HTH domain; Region: HTH_11; pfam08279 326424006820 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 326424006821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424006822 ATP binding site [chemical binding]; other site 326424006823 G-X-G motif; other site 326424006824 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 326424006825 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 326424006826 putative ligand binding site [chemical binding]; other site 326424006827 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 326424006828 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 326424006829 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 326424006830 Cytochrome P450; Region: p450; cl12078 326424006831 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 326424006832 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 326424006833 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326424006834 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 326424006835 dimerization interface [polypeptide binding]; other site 326424006836 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 326424006837 dimer interface [polypeptide binding]; other site 326424006838 FMN binding site [chemical binding]; other site 326424006839 NADPH bind site [chemical binding]; other site 326424006840 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 326424006841 catalytic residue [active] 326424006842 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 326424006843 acyl-CoA thioesterase II; Region: tesB; TIGR00189 326424006844 active site 326424006845 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 326424006846 active site 2 [active] 326424006847 active site 1 [active] 326424006848 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 326424006849 nif11-class peptide radical SAM maturase 3; Region: rSAM_nif11_3; TIGR04103 326424006850 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326424006851 FeS/SAM binding site; other site 326424006852 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 326424006853 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 326424006854 active site 326424006855 metal binding site [ion binding]; metal-binding site 326424006856 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 326424006857 hexamer interface [polypeptide binding]; other site 326424006858 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 326424006859 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 326424006860 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 326424006861 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 326424006862 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 326424006863 putative deacylase active site [active] 326424006864 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 326424006865 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 326424006866 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 326424006867 AAA ATPase domain; Region: AAA_16; pfam13191 326424006868 Hemerythrin-like domain; Region: Hr-like; cd12108 326424006869 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 326424006870 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 326424006871 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 326424006872 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 326424006873 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 326424006874 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 326424006875 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326424006876 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326424006877 active site 326424006878 catalytic tetrad [active] 326424006879 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 326424006880 Gas vesicle protein K; Region: GvpK; pfam05121 326424006881 gas vesicle synthesis-like protein; Reviewed; Region: PRK09368 326424006882 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 326424006883 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 326424006884 putative hydrophobic ligand binding site [chemical binding]; other site 326424006885 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 326424006886 putative hydrophobic ligand binding site [chemical binding]; other site 326424006887 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326424006888 dimerization interface [polypeptide binding]; other site 326424006889 putative DNA binding site [nucleotide binding]; other site 326424006890 putative Zn2+ binding site [ion binding]; other site 326424006891 Domain of unknown function (DUF222); Region: DUF222; pfam02720 326424006892 Domain of unknown function (DUF222); Region: DUF222; pfam02720 326424006893 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 326424006894 active site 326424006895 Predicted membrane protein [Function unknown]; Region: COG2259 326424006896 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424006897 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424006898 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 326424006899 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 326424006900 [2Fe-2S] cluster binding site [ion binding]; other site 326424006901 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 326424006902 putative alpha subunit interface [polypeptide binding]; other site 326424006903 putative active site [active] 326424006904 putative substrate binding site [chemical binding]; other site 326424006905 Fe binding site [ion binding]; other site 326424006906 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 326424006907 catalytic loop [active] 326424006908 iron binding site [ion binding]; other site 326424006909 hypothetical protein; Validated; Region: PRK07121 326424006910 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 326424006911 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 326424006912 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 326424006913 tetramer interface [polypeptide binding]; other site 326424006914 TPP-binding site [chemical binding]; other site 326424006915 heterodimer interface [polypeptide binding]; other site 326424006916 phosphorylation loop region [posttranslational modification] 326424006917 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 326424006918 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 326424006919 PYR/PP interface [polypeptide binding]; other site 326424006920 dimer interface [polypeptide binding]; other site 326424006921 TPP binding site [chemical binding]; other site 326424006922 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 326424006923 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 326424006924 E3 interaction surface; other site 326424006925 lipoyl attachment site [posttranslational modification]; other site 326424006926 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 326424006927 classical (c) SDRs; Region: SDR_c; cd05233 326424006928 NAD(P) binding site [chemical binding]; other site 326424006929 active site 326424006930 cytokinin dehydrogenase; Region: PLN02441 326424006931 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 326424006932 DNA binding site [nucleotide binding] 326424006933 Bacterial transcriptional activator domain; Region: BTAD; smart01043 326424006934 AAA ATPase domain; Region: AAA_16; pfam13191 326424006935 AAA domain; Region: AAA_22; pfam13401 326424006936 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 326424006937 hydrophobic ligand binding site; other site 326424006938 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 326424006939 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 326424006940 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 326424006941 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 326424006942 hypothetical protein; Provisional; Region: PRK06194 326424006943 classical (c) SDRs; Region: SDR_c; cd05233 326424006944 NAD(P) binding site [chemical binding]; other site 326424006945 active site 326424006946 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 326424006947 active site 1 [active] 326424006948 active site 2 [active] 326424006949 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424006950 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424006951 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 326424006952 putative active site [active] 326424006953 putative substrate binding site [chemical binding]; other site 326424006954 ATP binding site [chemical binding]; other site 326424006955 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424006956 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424006957 active site 326424006958 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 326424006959 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424006960 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 326424006961 classical (c) SDRs; Region: SDR_c; cd05233 326424006962 NAD(P) binding site [chemical binding]; other site 326424006963 active site 326424006964 SnoaL-like domain; Region: SnoaL_4; cl17707 326424006965 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 326424006966 Cytochrome P450; Region: p450; cl12078 326424006967 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 326424006968 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 326424006969 putative ligand binding site [chemical binding]; other site 326424006970 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 326424006971 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424006972 acyl-activating enzyme (AAE) consensus motif; other site 326424006973 AMP binding site [chemical binding]; other site 326424006974 active site 326424006975 CoA binding site [chemical binding]; other site 326424006976 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 326424006977 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326424006978 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 326424006979 dimerization interface [polypeptide binding]; other site 326424006980 substrate binding pocket [chemical binding]; other site 326424006981 Amidohydrolase; Region: Amidohydro_2; pfam04909 326424006982 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 326424006983 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 326424006984 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 326424006985 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 326424006986 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 326424006987 ATP-grasp domain; Region: ATP-grasp_4; cl17255 326424006988 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 326424006989 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326424006990 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326424006991 homodimer interface [polypeptide binding]; other site 326424006992 catalytic residue [active] 326424006993 Probable transposase; Region: OrfB_IS605; pfam01385 326424006994 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 326424006995 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 326424006996 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 326424006997 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 326424006998 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 326424006999 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 326424007000 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 326424007001 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 326424007002 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 326424007003 membrane-bound complex binding site; other site 326424007004 hinge residues; other site 326424007005 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 326424007006 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 326424007007 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 326424007008 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 326424007009 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 326424007010 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 326424007011 lipid-transfer protein; Provisional; Region: PRK07855 326424007012 active site 326424007013 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 326424007014 classical (c) SDRs; Region: SDR_c; cd05233 326424007015 NAD(P) binding site [chemical binding]; other site 326424007016 active site 326424007017 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 326424007018 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 326424007019 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 326424007020 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424007021 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 326424007022 acyl-activating enzyme (AAE) consensus motif; other site 326424007023 acyl-activating enzyme (AAE) consensus motif; other site 326424007024 putative AMP binding site [chemical binding]; other site 326424007025 putative active site [active] 326424007026 active site 326424007027 AMP binding site [chemical binding]; other site 326424007028 putative CoA binding site [chemical binding]; other site 326424007029 CoA binding site [chemical binding]; other site 326424007030 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424007031 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424007032 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 326424007033 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 326424007034 TM-ABC transporter signature motif; other site 326424007035 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 326424007036 TM-ABC transporter signature motif; other site 326424007037 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 326424007038 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 326424007039 Walker A/P-loop; other site 326424007040 ATP binding site [chemical binding]; other site 326424007041 Q-loop/lid; other site 326424007042 ABC transporter signature motif; other site 326424007043 Walker B; other site 326424007044 D-loop; other site 326424007045 H-loop/switch region; other site 326424007046 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 326424007047 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 326424007048 Walker A/P-loop; other site 326424007049 ATP binding site [chemical binding]; other site 326424007050 Q-loop/lid; other site 326424007051 ABC transporter signature motif; other site 326424007052 Walker B; other site 326424007053 D-loop; other site 326424007054 H-loop/switch region; other site 326424007055 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 326424007056 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 326424007057 dimer interface [polypeptide binding]; other site 326424007058 active site 326424007059 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 326424007060 CoA-transferase family III; Region: CoA_transf_3; pfam02515 326424007061 Phosphotransferase enzyme family; Region: APH; pfam01636 326424007062 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 326424007063 putative active site [active] 326424007064 ATP binding site [chemical binding]; other site 326424007065 putative substrate binding site [chemical binding]; other site 326424007066 Amidohydrolase; Region: Amidohydro_2; pfam04909 326424007067 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 326424007068 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 326424007069 putative ligand binding site [chemical binding]; other site 326424007070 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326424007071 putative DNA binding site [nucleotide binding]; other site 326424007072 putative Zn2+ binding site [ion binding]; other site 326424007073 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424007074 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424007075 S-adenosylmethionine binding site [chemical binding]; other site 326424007076 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 326424007077 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424007078 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424007079 active site 326424007080 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 326424007081 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 326424007082 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 326424007083 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424007084 acyl-activating enzyme (AAE) consensus motif; other site 326424007085 AMP binding site [chemical binding]; other site 326424007086 active site 326424007087 CoA binding site [chemical binding]; other site 326424007088 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 326424007089 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424007090 substrate binding site [chemical binding]; other site 326424007091 oxyanion hole (OAH) forming residues; other site 326424007092 trimer interface [polypeptide binding]; other site 326424007093 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 326424007094 active site 2 [active] 326424007095 active site 1 [active] 326424007096 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 326424007097 active site 2 [active] 326424007098 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424007099 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 326424007100 NAD(P) binding site [chemical binding]; other site 326424007101 active site 326424007102 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424007103 NAD(P) binding site [chemical binding]; other site 326424007104 active site 326424007105 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 326424007106 putative active site [active] 326424007107 putative catalytic site [active] 326424007108 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 326424007109 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 326424007110 hydroxyglutarate oxidase; Provisional; Region: PRK11728 326424007111 Predicted dehydrogenase [General function prediction only]; Region: COG0579 326424007112 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424007113 NAD(P) binding site [chemical binding]; other site 326424007114 active site 326424007115 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 326424007116 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 326424007117 NAD(P) binding site [chemical binding]; other site 326424007118 catalytic residues [active] 326424007119 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 326424007120 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 326424007121 active site 326424007122 NAD binding site [chemical binding]; other site 326424007123 metal binding site [ion binding]; metal-binding site 326424007124 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424007125 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 326424007126 Tandem repeat subunit of reelin and related proteins; Region: Reelin_subrepeat_like; cl15240 326424007127 Transcriptional regulators [Transcription]; Region: FadR; COG2186 326424007128 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326424007129 DNA-binding site [nucleotide binding]; DNA binding site 326424007130 FCD domain; Region: FCD; pfam07729 326424007131 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 326424007132 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 326424007133 Walker A/P-loop; other site 326424007134 ATP binding site [chemical binding]; other site 326424007135 Q-loop/lid; other site 326424007136 ABC transporter signature motif; other site 326424007137 Walker B; other site 326424007138 D-loop; other site 326424007139 H-loop/switch region; other site 326424007140 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 326424007141 TM-ABC transporter signature motif; other site 326424007142 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 326424007143 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 326424007144 TM-ABC transporter signature motif; other site 326424007145 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 326424007146 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 326424007147 Walker A/P-loop; other site 326424007148 ATP binding site [chemical binding]; other site 326424007149 Q-loop/lid; other site 326424007150 ABC transporter signature motif; other site 326424007151 Walker B; other site 326424007152 D-loop; other site 326424007153 H-loop/switch region; other site 326424007154 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 326424007155 CoA-transferase family III; Region: CoA_transf_3; pfam02515 326424007156 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 326424007157 Amidohydrolase; Region: Amidohydro_2; pfam04909 326424007158 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 326424007159 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 326424007160 putative ligand binding site [chemical binding]; other site 326424007161 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424007162 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424007163 active site 326424007164 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424007165 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 326424007166 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 326424007167 active site 326424007168 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 326424007169 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 326424007170 ligand binding site [chemical binding]; other site 326424007171 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 326424007172 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424007173 substrate binding site [chemical binding]; other site 326424007174 oxyanion hole (OAH) forming residues; other site 326424007175 trimer interface [polypeptide binding]; other site 326424007176 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 326424007177 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424007178 NAD(P) binding site [chemical binding]; other site 326424007179 active site 326424007180 Domain of unknown function (DUF222); Region: DUF222; pfam02720 326424007181 Domain of unknown function (DUF222); Region: DUF222; pfam02720 326424007182 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 326424007183 active site 326424007184 Isochorismatase family; Region: Isochorismatase; pfam00857 326424007185 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 326424007186 catalytic triad [active] 326424007187 conserved cis-peptide bond; other site 326424007188 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 326424007189 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 326424007190 acyl-activating enzyme (AAE) consensus motif; other site 326424007191 putative active site [active] 326424007192 putative AMP binding site [chemical binding]; other site 326424007193 putative CoA binding site [chemical binding]; other site 326424007194 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424007195 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424007196 active site 326424007197 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424007198 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424007199 active site 326424007200 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424007201 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 326424007202 active site 326424007203 coenzyme F420-dependent oxidoreductase, NP1902A family; Region: F420_NP1902A; TIGR04024 326424007204 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 326424007205 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 326424007206 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 326424007207 SPFH domain / Band 7 family; Region: Band_7; pfam01145 326424007208 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 326424007209 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 326424007210 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 326424007211 Predicted transcriptional regulators [Transcription]; Region: COG1733 326424007212 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 326424007213 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424007214 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424007215 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 326424007216 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 326424007217 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 326424007218 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 326424007219 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 326424007220 ATP-grasp domain; Region: ATP-grasp_4; cl17255 326424007221 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 326424007222 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 326424007223 carboxyltransferase (CT) interaction site; other site 326424007224 biotinylation site [posttranslational modification]; other site 326424007225 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424007226 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424007227 active site 326424007228 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 326424007229 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 326424007230 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 326424007231 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 326424007232 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326424007233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424007234 active site 326424007235 phosphorylation site [posttranslational modification] 326424007236 intermolecular recognition site; other site 326424007237 dimerization interface [polypeptide binding]; other site 326424007238 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 326424007239 DNA binding site [nucleotide binding] 326424007240 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 326424007241 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 326424007242 Isochorismatase family; Region: Isochorismatase; pfam00857 326424007243 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 326424007244 catalytic triad [active] 326424007245 conserved cis-peptide bond; other site 326424007246 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 326424007247 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 326424007248 tetramer interface [polypeptide binding]; other site 326424007249 heme binding pocket [chemical binding]; other site 326424007250 NADPH binding site [chemical binding]; other site 326424007251 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 326424007252 metal binding site 2 [ion binding]; metal-binding site 326424007253 putative DNA binding helix; other site 326424007254 metal binding site 1 [ion binding]; metal-binding site 326424007255 dimer interface [polypeptide binding]; other site 326424007256 structural Zn2+ binding site [ion binding]; other site 326424007257 Phosphotransferase enzyme family; Region: APH; pfam01636 326424007258 Ecdysteroid kinase; Region: EcKinase; cl17738 326424007259 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 326424007260 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326424007261 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 326424007262 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 326424007263 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 326424007264 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 326424007265 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 326424007266 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326424007267 catalytic residue [active] 326424007268 Protein of unknown function (DUF664); Region: DUF664; pfam04978 326424007269 DinB superfamily; Region: DinB_2; pfam12867 326424007270 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424007271 active site 326424007272 AMP binding site [chemical binding]; other site 326424007273 acyl-activating enzyme (AAE) consensus motif; other site 326424007274 CoA binding site [chemical binding]; other site 326424007275 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 326424007276 NAD(P) binding site [chemical binding]; other site 326424007277 catalytic residues [active] 326424007278 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 326424007279 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 326424007280 CoenzymeA binding site [chemical binding]; other site 326424007281 subunit interaction site [polypeptide binding]; other site 326424007282 PHB binding site; other site 326424007283 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 326424007284 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 326424007285 acyl-activating enzyme (AAE) consensus motif; other site 326424007286 active site 326424007287 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 326424007288 dinuclear metal binding motif [ion binding]; other site 326424007289 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 326424007290 PHB binding site; other site 326424007291 CoenzymeA binding site [chemical binding]; other site 326424007292 subunit interaction site [polypeptide binding]; other site 326424007293 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326424007294 Methyltransferase domain; Region: Methyltransf_23; pfam13489 326424007295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424007296 S-adenosylmethionine binding site [chemical binding]; other site 326424007297 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 326424007298 dinuclear metal binding motif [ion binding]; other site 326424007299 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 326424007300 Cytochrome P450; Region: p450; cl12078 326424007301 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 326424007302 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326424007303 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 326424007304 dimerization interface [polypeptide binding]; other site 326424007305 substrate binding pocket [chemical binding]; other site 326424007306 AMP-binding enzyme; Region: AMP-binding; pfam00501 326424007307 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424007308 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 326424007309 acyl-activating enzyme (AAE) consensus motif; other site 326424007310 putative AMP binding site [chemical binding]; other site 326424007311 putative active site [active] 326424007312 putative CoA binding site [chemical binding]; other site 326424007313 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 326424007314 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 326424007315 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 326424007316 active site 326424007317 catalytic triad [active] 326424007318 oxyanion hole [active] 326424007319 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326424007320 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326424007321 active site 326424007322 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 326424007323 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 326424007324 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326424007325 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326424007326 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326424007327 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 326424007328 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326424007329 putative NADP binding site [chemical binding]; other site 326424007330 active site 326424007331 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326424007332 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 326424007333 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 326424007334 active site 1 [active] 326424007335 dimer interface [polypeptide binding]; other site 326424007336 active site 2 [active] 326424007337 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 326424007338 FMN binding site [chemical binding]; other site 326424007339 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 326424007340 substrate binding site [chemical binding]; other site 326424007341 putative catalytic residue [active] 326424007342 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 326424007343 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 326424007344 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 326424007345 carboxyltransferase (CT) interaction site; other site 326424007346 biotinylation site [posttranslational modification]; other site 326424007347 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 326424007348 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 326424007349 ATP-grasp domain; Region: ATP-grasp_4; cl17255 326424007350 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 326424007351 Domain of unknown function (DUF222); Region: DUF222; pfam02720 326424007352 Domain of unknown function (DUF222); Region: DUF222; pfam02720 326424007353 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 326424007354 active site 326424007355 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326424007356 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 326424007357 active site 326424007358 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 326424007359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424007360 dimer interface [polypeptide binding]; other site 326424007361 conserved gate region; other site 326424007362 putative PBP binding loops; other site 326424007363 ABC-ATPase subunit interface; other site 326424007364 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 326424007365 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 326424007366 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 326424007367 active site 326424007368 metal binding site [ion binding]; metal-binding site 326424007369 hexamer interface [polypeptide binding]; other site 326424007370 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 326424007371 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 326424007372 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 326424007373 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 326424007374 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 326424007375 Walker A/P-loop; other site 326424007376 ATP binding site [chemical binding]; other site 326424007377 Q-loop/lid; other site 326424007378 ABC transporter signature motif; other site 326424007379 Walker B; other site 326424007380 D-loop; other site 326424007381 H-loop/switch region; other site 326424007382 TOBE domain; Region: TOBE_2; pfam08402 326424007383 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 326424007384 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 326424007385 CoenzymeA binding site [chemical binding]; other site 326424007386 subunit interaction site [polypeptide binding]; other site 326424007387 PHB binding site; other site 326424007388 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424007389 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 326424007390 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 326424007391 active site 326424007392 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 326424007393 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 326424007394 FMN-binding pocket [chemical binding]; other site 326424007395 flavin binding motif; other site 326424007396 phosphate binding motif [ion binding]; other site 326424007397 beta-alpha-beta structure motif; other site 326424007398 NAD binding pocket [chemical binding]; other site 326424007399 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 326424007400 catalytic loop [active] 326424007401 iron binding site [ion binding]; other site 326424007402 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 326424007403 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 326424007404 Cytochrome P450; Region: p450; cl12078 326424007405 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 326424007406 Cytochrome P450; Region: p450; cl12078 326424007407 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 326424007408 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 326424007409 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 326424007410 Cytochrome P450; Region: p450; cl12078 326424007411 HicB family; Region: HicB; pfam05534 326424007412 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 326424007413 Phosphoesterase family; Region: Phosphoesterase; pfam04185 326424007414 translocation protein TolB; Provisional; Region: tolB; PRK02889 326424007415 SnoaL-like domain; Region: SnoaL_2; pfam12680 326424007416 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424007417 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424007418 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 326424007419 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 326424007420 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 326424007421 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 326424007422 P-loop; other site 326424007423 Magnesium ion binding site [ion binding]; other site 326424007424 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 326424007425 Magnesium ion binding site [ion binding]; other site 326424007426 prephenate dehydratase; Provisional; Region: PRK11898 326424007427 Prephenate dehydratase; Region: PDT; pfam00800 326424007428 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 326424007429 putative L-Phe binding site [chemical binding]; other site 326424007430 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 326424007431 E3 interaction surface; other site 326424007432 lipoyl attachment site [posttranslational modification]; other site 326424007433 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 326424007434 e3 binding domain; Region: E3_binding; pfam02817 326424007435 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 326424007436 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 326424007437 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 326424007438 alpha subunit interface [polypeptide binding]; other site 326424007439 TPP binding site [chemical binding]; other site 326424007440 heterodimer interface [polypeptide binding]; other site 326424007441 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 326424007442 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 326424007443 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 326424007444 tetramer interface [polypeptide binding]; other site 326424007445 TPP-binding site [chemical binding]; other site 326424007446 heterodimer interface [polypeptide binding]; other site 326424007447 phosphorylation loop region [posttranslational modification] 326424007448 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 326424007449 Bacitracin resistance protein BacA; Region: BacA; pfam02673 326424007450 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 326424007451 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 326424007452 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 326424007453 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 326424007454 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 326424007455 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 326424007456 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 326424007457 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 326424007458 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 326424007459 Peptidase family M48; Region: Peptidase_M48; cl12018 326424007460 Domain of unknown function (DUF385); Region: DUF385; cl04387 326424007461 Amidohydrolase; Region: Amidohydro_2; pfam04909 326424007462 Hemerythrin-like domain; Region: Hr-like; cd12108 326424007463 Fe binding site [ion binding]; other site 326424007464 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 326424007465 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424007466 NAD(P) binding site [chemical binding]; other site 326424007467 active site 326424007468 hypothetical protein; Provisional; Region: PRK08201 326424007469 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 326424007470 metal binding site [ion binding]; metal-binding site 326424007471 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 326424007472 classical (c) SDRs; Region: SDR_c; cd05233 326424007473 NAD(P) binding site [chemical binding]; other site 326424007474 active site 326424007475 PAS fold; Region: PAS_4; pfam08448 326424007476 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 326424007477 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 326424007478 metal binding site [ion binding]; metal-binding site 326424007479 active site 326424007480 I-site; other site 326424007481 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 326424007482 Clp amino terminal domain; Region: Clp_N; pfam02861 326424007483 Clp amino terminal domain; Region: Clp_N; pfam02861 326424007484 Protein of unknown function (DUF972); Region: DUF972; pfam06156 326424007485 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 326424007486 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 326424007487 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 326424007488 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 326424007489 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 326424007490 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 326424007491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424007492 putative substrate translocation pore; other site 326424007493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424007494 NAD synthetase; Reviewed; Region: nadE; PRK02628 326424007495 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 326424007496 multimer interface [polypeptide binding]; other site 326424007497 active site 326424007498 catalytic triad [active] 326424007499 protein interface 1 [polypeptide binding]; other site 326424007500 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 326424007501 homodimer interface [polypeptide binding]; other site 326424007502 NAD binding pocket [chemical binding]; other site 326424007503 ATP binding pocket [chemical binding]; other site 326424007504 Mg binding site [ion binding]; other site 326424007505 active-site loop [active] 326424007506 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 326424007507 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 326424007508 dimer interface [polypeptide binding]; other site 326424007509 PYR/PP interface [polypeptide binding]; other site 326424007510 TPP binding site [chemical binding]; other site 326424007511 substrate binding site [chemical binding]; other site 326424007512 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 326424007513 Domain of unknown function; Region: EKR; pfam10371 326424007514 4Fe-4S binding domain; Region: Fer4_6; pfam12837 326424007515 4Fe-4S binding domain; Region: Fer4; pfam00037 326424007516 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 326424007517 TPP-binding site [chemical binding]; other site 326424007518 dimer interface [polypeptide binding]; other site 326424007519 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 326424007520 heme-binding site [chemical binding]; other site 326424007521 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 326424007522 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 326424007523 Cation efflux family; Region: Cation_efflux; pfam01545 326424007524 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424007525 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424007526 active site 326424007527 ATP binding site [chemical binding]; other site 326424007528 substrate binding site [chemical binding]; other site 326424007529 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 326424007530 substrate binding site [chemical binding]; other site 326424007531 activation loop (A-loop); other site 326424007532 activation loop (A-loop); other site 326424007533 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424007534 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424007535 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 326424007536 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424007537 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424007538 active site 326424007539 phosphorylation site [posttranslational modification] 326424007540 intermolecular recognition site; other site 326424007541 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326424007542 DNA binding residues [nucleotide binding] 326424007543 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 326424007544 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 326424007545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424007546 ATP binding site [chemical binding]; other site 326424007547 Mg2+ binding site [ion binding]; other site 326424007548 G-X-G motif; other site 326424007549 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 326424007550 nucleotide binding site [chemical binding]; other site 326424007551 putative NEF/HSP70 interaction site [polypeptide binding]; other site 326424007552 SBD interface [polypeptide binding]; other site 326424007553 Predicted transcriptional regulators [Transcription]; Region: COG1733 326424007554 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 326424007555 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 326424007556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424007557 putative substrate translocation pore; other site 326424007558 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 326424007559 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 326424007560 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 326424007561 oligomer interface [polypeptide binding]; other site 326424007562 metal binding site [ion binding]; metal-binding site 326424007563 metal binding site [ion binding]; metal-binding site 326424007564 putative Cl binding site [ion binding]; other site 326424007565 aspartate ring; other site 326424007566 basic sphincter; other site 326424007567 hydrophobic gate; other site 326424007568 periplasmic entrance; other site 326424007569 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 326424007570 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 326424007571 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 326424007572 Predicted flavoprotein [General function prediction only]; Region: COG0431 326424007573 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 326424007574 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 326424007575 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 326424007576 active site 326424007577 iron coordination sites [ion binding]; other site 326424007578 substrate binding pocket [chemical binding]; other site 326424007579 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 326424007580 active site 326424007581 catalytic triad [active] 326424007582 oxyanion hole [active] 326424007583 Putative esterase; Region: Esterase; pfam00756 326424007584 S-formylglutathione hydrolase; Region: PLN02442 326424007585 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 326424007586 catalytic site [active] 326424007587 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 326424007588 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 326424007589 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424007590 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 326424007591 active site 326424007592 ATP binding site [chemical binding]; other site 326424007593 substrate binding site [chemical binding]; other site 326424007594 activation loop (A-loop); other site 326424007595 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 326424007596 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 326424007597 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 326424007598 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 326424007599 classical (c) SDRs; Region: SDR_c; cd05233 326424007600 NAD(P) binding site [chemical binding]; other site 326424007601 active site 326424007602 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 326424007603 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424007604 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424007605 active site 326424007606 ATP binding site [chemical binding]; other site 326424007607 substrate binding site [chemical binding]; other site 326424007608 activation loop (A-loop); other site 326424007609 FOG: WD40 repeat [General function prediction only]; Region: COG2319 326424007610 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 326424007611 structural tetrad; other site 326424007612 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 326424007613 heme-binding site [chemical binding]; other site 326424007614 effector protein; Provisional; Region: PRK14052 326424007615 ANTAR domain; Region: ANTAR; pfam03861 326424007616 HEAT repeats; Region: HEAT_2; pfam13646 326424007617 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 326424007618 HsdM N-terminal domain; Region: HsdM_N; pfam12161 326424007619 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 326424007620 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 326424007621 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 326424007622 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 326424007623 TIGR03084 family protein; Region: TIGR03084 326424007624 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 326424007625 Wyosine base formation; Region: Wyosine_form; pfam08608 326424007626 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424007627 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424007628 short chain dehydrogenase; Provisional; Region: PRK07041 326424007629 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424007630 NAD(P) binding site [chemical binding]; other site 326424007631 active site 326424007632 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326424007633 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 326424007634 Restriction endonuclease; Region: Mrr_cat; pfam04471 326424007635 HNH endonuclease; Region: HNH_2; pfam13391 326424007636 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 326424007637 TIR domain; Region: TIR_2; pfam13676 326424007638 AAA ATPase domain; Region: AAA_16; pfam13191 326424007639 AAA domain; Region: AAA_22; pfam13401 326424007640 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424007641 Tetratricopeptide repeat; Region: TPR_10; pfam13374 326424007642 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424007643 Tetratricopeptide repeat; Region: TPR_10; pfam13374 326424007644 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424007645 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 326424007646 binding surface 326424007647 TPR motif; other site 326424007648 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424007649 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424007650 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424007651 Tetratricopeptide repeat; Region: TPR_10; pfam13374 326424007652 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424007653 non-specific DNA binding site [nucleotide binding]; other site 326424007654 salt bridge; other site 326424007655 sequence-specific DNA binding site [nucleotide binding]; other site 326424007656 AAA domain; Region: AAA_14; pfam13173 326424007657 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 326424007658 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 326424007659 classical (c) SDRs; Region: SDR_c; cd05233 326424007660 NAD(P) binding site [chemical binding]; other site 326424007661 active site 326424007662 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424007663 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 326424007664 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424007665 Walker A/P-loop; other site 326424007666 ATP binding site [chemical binding]; other site 326424007667 Q-loop/lid; other site 326424007668 ABC transporter signature motif; other site 326424007669 Walker B; other site 326424007670 D-loop; other site 326424007671 H-loop/switch region; other site 326424007672 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 326424007673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424007674 dimer interface [polypeptide binding]; other site 326424007675 conserved gate region; other site 326424007676 putative PBP binding loops; other site 326424007677 ABC-ATPase subunit interface; other site 326424007678 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 326424007679 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 326424007680 membrane-bound complex binding site; other site 326424007681 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 326424007682 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 326424007683 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 326424007684 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424007685 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 326424007686 NADH(P)-binding; Region: NAD_binding_10; pfam13460 326424007687 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424007688 NAD(P) binding site [chemical binding]; other site 326424007689 active site 326424007690 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 326424007691 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 326424007692 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 326424007693 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 326424007694 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 326424007695 Cysteine-rich domain; Region: CCG; pfam02754 326424007696 Cysteine-rich domain; Region: CCG; pfam02754 326424007697 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 326424007698 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 326424007699 dimer interface [polypeptide binding]; other site 326424007700 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326424007701 catalytic residue [active] 326424007702 serine O-acetyltransferase; Region: cysE; TIGR01172 326424007703 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 326424007704 trimer interface [polypeptide binding]; other site 326424007705 active site 326424007706 substrate binding site [chemical binding]; other site 326424007707 CoA binding site [chemical binding]; other site 326424007708 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 326424007709 active site 326424007710 catalytic site [active] 326424007711 putative metal binding site [ion binding]; other site 326424007712 Tannase and feruloyl esterase; Region: Tannase; pfam07519 326424007713 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 326424007714 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 326424007715 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 326424007716 putative DNA binding site [nucleotide binding]; other site 326424007717 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 326424007718 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 326424007719 putative Zn2+ binding site [ion binding]; other site 326424007720 AsnC family; Region: AsnC_trans_reg; pfam01037 326424007721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424007722 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 326424007723 putative substrate translocation pore; other site 326424007724 Maf-like protein; Region: Maf; pfam02545 326424007725 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 326424007726 active site 326424007727 dimer interface [polypeptide binding]; other site 326424007728 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 326424007729 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326424007730 FeS/SAM binding site; other site 326424007731 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 326424007732 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 326424007733 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 326424007734 TM-ABC transporter signature motif; other site 326424007735 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 326424007736 TM-ABC transporter signature motif; other site 326424007737 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 326424007738 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 326424007739 Walker A/P-loop; other site 326424007740 ATP binding site [chemical binding]; other site 326424007741 Q-loop/lid; other site 326424007742 ABC transporter signature motif; other site 326424007743 Walker B; other site 326424007744 D-loop; other site 326424007745 H-loop/switch region; other site 326424007746 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 326424007747 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 326424007748 Walker A/P-loop; other site 326424007749 ATP binding site [chemical binding]; other site 326424007750 Q-loop/lid; other site 326424007751 ABC transporter signature motif; other site 326424007752 Walker B; other site 326424007753 D-loop; other site 326424007754 H-loop/switch region; other site 326424007755 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 326424007756 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 326424007757 acyl-activating enzyme (AAE) consensus motif; other site 326424007758 putative AMP binding site [chemical binding]; other site 326424007759 putative active site [active] 326424007760 putative CoA binding site [chemical binding]; other site 326424007761 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 326424007762 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 326424007763 putative NAD(P) binding site [chemical binding]; other site 326424007764 putative active site [active] 326424007765 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 326424007766 Cytochrome P450; Region: p450; cl12078 326424007767 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 326424007768 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 326424007769 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 326424007770 putative ligand binding site [chemical binding]; other site 326424007771 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 326424007772 amphipathic channel; other site 326424007773 Asn-Pro-Ala signature motifs; other site 326424007774 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 326424007775 Low molecular weight phosphatase family; Region: LMWPc; cd00115 326424007776 active site 326424007777 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 326424007778 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326424007779 putative metal binding site [ion binding]; other site 326424007780 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326424007781 dimerization interface [polypeptide binding]; other site 326424007782 putative DNA binding site [nucleotide binding]; other site 326424007783 putative Zn2+ binding site [ion binding]; other site 326424007784 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 326424007785 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 326424007786 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 326424007787 active site 2 [active] 326424007788 active site 1 [active] 326424007789 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 326424007790 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 326424007791 Phosphotransferase enzyme family; Region: APH; pfam01636 326424007792 putative active site [active] 326424007793 putative substrate binding site [chemical binding]; other site 326424007794 ATP binding site [chemical binding]; other site 326424007795 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 326424007796 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424007797 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 326424007798 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 326424007799 NAD binding site [chemical binding]; other site 326424007800 catalytic residues [active] 326424007801 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 326424007802 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 326424007803 NAD binding site [chemical binding]; other site 326424007804 catalytic Zn binding site [ion binding]; other site 326424007805 substrate binding site [chemical binding]; other site 326424007806 structural Zn binding site [ion binding]; other site 326424007807 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 326424007808 Cytochrome P450; Region: p450; cl12078 326424007809 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 326424007810 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 326424007811 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 326424007812 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 326424007813 Domain of unknown function (DUF222); Region: DUF222; pfam02720 326424007814 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 326424007815 active site 326424007816 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424007817 S-adenosylmethionine binding site [chemical binding]; other site 326424007818 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 326424007819 active site 2 [active] 326424007820 active site 1 [active] 326424007821 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 326424007822 CoenzymeA binding site [chemical binding]; other site 326424007823 subunit interaction site [polypeptide binding]; other site 326424007824 PHB binding site; other site 326424007825 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424007826 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424007827 active site 326424007828 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 326424007829 CoA-transferase family III; Region: CoA_transf_3; pfam02515 326424007830 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 326424007831 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 326424007832 SnoaL-like domain; Region: SnoaL_4; pfam13577 326424007833 ferredoxin-NADP+ reductase; Region: PLN02852 326424007834 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 326424007835 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 326424007836 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 326424007837 putative ligand binding site [chemical binding]; other site 326424007838 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 326424007839 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424007840 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424007841 acyl-activating enzyme (AAE) consensus motif; other site 326424007842 AMP binding site [chemical binding]; other site 326424007843 active site 326424007844 CoA binding site [chemical binding]; other site 326424007845 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 326424007846 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 326424007847 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 326424007848 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 326424007849 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 326424007850 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 326424007851 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424007852 substrate binding site [chemical binding]; other site 326424007853 oxyanion hole (OAH) forming residues; other site 326424007854 trimer interface [polypeptide binding]; other site 326424007855 Isochorismatase family; Region: Isochorismatase; pfam00857 326424007856 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 326424007857 catalytic triad [active] 326424007858 conserved cis-peptide bond; other site 326424007859 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 326424007860 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 326424007861 acyl-activating enzyme (AAE) consensus motif; other site 326424007862 putative AMP binding site [chemical binding]; other site 326424007863 putative active site [active] 326424007864 putative CoA binding site [chemical binding]; other site 326424007865 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 326424007866 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424007867 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 326424007868 acyl-activating enzyme (AAE) consensus motif; other site 326424007869 acyl-activating enzyme (AAE) consensus motif; other site 326424007870 putative AMP binding site [chemical binding]; other site 326424007871 putative active site [active] 326424007872 putative CoA binding site [chemical binding]; other site 326424007873 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 326424007874 inter-subunit interface; other site 326424007875 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 326424007876 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 326424007877 iron-sulfur cluster [ion binding]; other site 326424007878 [2Fe-2S] cluster binding site [ion binding]; other site 326424007879 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 326424007880 putative alpha subunit interface [polypeptide binding]; other site 326424007881 putative active site [active] 326424007882 putative substrate binding site [chemical binding]; other site 326424007883 Fe binding site [ion binding]; other site 326424007884 DUF35 OB-fold domain; Region: DUF35; pfam01796 326424007885 thiolase; Provisional; Region: PRK06158 326424007886 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 326424007887 active site 326424007888 The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6, and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348 326424007889 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326424007890 putative active site [active] 326424007891 putative metal binding site [ion binding]; other site 326424007892 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 326424007893 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 326424007894 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 326424007895 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 326424007896 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 326424007897 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 326424007898 NAD(P) binding site [chemical binding]; other site 326424007899 catalytic residues [active] 326424007900 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 326424007901 CoA-transferase family III; Region: CoA_transf_3; pfam02515 326424007902 Domain of unknown function (DUF222); Region: DUF222; pfam02720 326424007903 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 326424007904 active site 326424007905 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424007906 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424007907 active site 326424007908 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 326424007909 putative active site [active] 326424007910 putative catalytic site [active] 326424007911 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424007912 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 326424007913 FAD binding site [chemical binding]; other site 326424007914 substrate binding site [chemical binding]; other site 326424007915 catalytic base [active] 326424007916 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424007917 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424007918 active site 326424007919 thiolase; Provisional; Region: PRK06158 326424007920 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 326424007921 active site 326424007922 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 326424007923 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424007924 acyl-activating enzyme (AAE) consensus motif; other site 326424007925 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424007926 AMP binding site [chemical binding]; other site 326424007927 active site 326424007928 acyl-activating enzyme (AAE) consensus motif; other site 326424007929 CoA binding site [chemical binding]; other site 326424007930 short chain dehydrogenase; Provisional; Region: PRK07791 326424007931 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424007932 NAD(P) binding site [chemical binding]; other site 326424007933 active site 326424007934 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 326424007935 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 326424007936 DUF35 OB-fold domain; Region: DUF35; pfam01796 326424007937 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424007938 enoyl-CoA hydratase; Provisional; Region: PRK06688 326424007939 substrate binding site [chemical binding]; other site 326424007940 oxyanion hole (OAH) forming residues; other site 326424007941 trimer interface [polypeptide binding]; other site 326424007942 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424007943 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 326424007944 NAD(P) binding site [chemical binding]; other site 326424007945 active site 326424007946 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424007947 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 326424007948 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 326424007949 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424007950 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 326424007951 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 326424007952 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 326424007953 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424007954 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424007955 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424007956 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424007957 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 326424007958 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 326424007959 putative NAD(P) binding site [chemical binding]; other site 326424007960 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424007961 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 326424007962 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 326424007963 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 326424007964 FMN binding site [chemical binding]; other site 326424007965 substrate binding site [chemical binding]; other site 326424007966 putative catalytic residue [active] 326424007967 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 326424007968 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 326424007969 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 326424007970 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 326424007971 chorismate binding enzyme; Region: Chorismate_bind; cl10555 326424007972 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 326424007973 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 326424007974 conserved cys residue [active] 326424007975 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 326424007976 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 326424007977 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424007978 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424007979 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 326424007980 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 326424007981 putative NAD(P) binding site [chemical binding]; other site 326424007982 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 326424007983 homotrimer interaction site [polypeptide binding]; other site 326424007984 putative active site [active] 326424007985 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326424007986 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326424007987 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326424007988 active site 326424007989 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 326424007990 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 326424007991 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 326424007992 NADP binding site [chemical binding]; other site 326424007993 KR domain; Region: KR; pfam08659 326424007994 active site 326424007995 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326424007996 Thioesterase; Region: PKS_TE; smart00824 326424007997 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 326424007998 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 326424007999 putative active site [active] 326424008000 catalytic site [active] 326424008001 putative metal binding site [ion binding]; other site 326424008002 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 326424008003 Fatty acid desaturase; Region: FA_desaturase; pfam00487 326424008004 Di-iron ligands [ion binding]; other site 326424008005 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 326424008006 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326424008007 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 326424008008 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424008009 S-adenosylmethionine binding site [chemical binding]; other site 326424008010 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 326424008011 Cytochrome P450; Region: p450; cl12078 326424008012 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 326424008013 acyl-CoA synthetase; Validated; Region: PRK05850 326424008014 acyl-activating enzyme (AAE) consensus motif; other site 326424008015 active site 326424008016 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 326424008017 CoenzymeA binding site [chemical binding]; other site 326424008018 subunit interaction site [polypeptide binding]; other site 326424008019 PHB binding site; other site 326424008020 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 326424008021 Domain of unknown function (DUF222); Region: DUF222; pfam02720 326424008022 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 326424008023 active site 326424008024 FAD binding domain; Region: FAD_binding_3; pfam01494 326424008025 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 326424008026 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 326424008027 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 326424008028 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 326424008029 CoenzymeA binding site [chemical binding]; other site 326424008030 subunit interaction site [polypeptide binding]; other site 326424008031 PHB binding site; other site 326424008032 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 326424008033 CoenzymeA binding site [chemical binding]; other site 326424008034 subunit interaction site [polypeptide binding]; other site 326424008035 PHB binding site; other site 326424008036 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424008037 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 326424008038 NAD(P) binding site [chemical binding]; other site 326424008039 active site 326424008040 Transcriptional regulators [Transcription]; Region: FadR; COG2186 326424008041 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326424008042 DNA-binding site [nucleotide binding]; DNA binding site 326424008043 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 326424008044 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424008045 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 326424008046 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 326424008047 active site 326424008048 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424008049 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424008050 active site 326424008051 Transcriptional regulators [Transcription]; Region: FadR; COG2186 326424008052 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326424008053 DNA-binding site [nucleotide binding]; DNA binding site 326424008054 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 326424008055 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 326424008056 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 326424008057 putative ligand binding site [chemical binding]; other site 326424008058 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 326424008059 CoA-transferase family III; Region: CoA_transf_3; pfam02515 326424008060 putative phosphoketolase; Provisional; Region: PRK05261 326424008061 XFP N-terminal domain; Region: XFP_N; pfam09364 326424008062 XFP C-terminal domain; Region: XFP_C; pfam09363 326424008063 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 326424008064 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 326424008065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424008066 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424008067 active site 326424008068 dimerization interface [polypeptide binding]; other site 326424008069 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 326424008070 short chain dehydrogenase; Provisional; Region: PRK07109 326424008071 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 326424008072 putative NAD(P) binding site [chemical binding]; other site 326424008073 active site 326424008074 Amidohydrolase; Region: Amidohydro_2; pfam04909 326424008075 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 326424008076 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424008077 NAD(P) binding site [chemical binding]; other site 326424008078 active site 326424008079 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 326424008080 CoA-transferase family III; Region: CoA_transf_3; pfam02515 326424008081 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 326424008082 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424008083 NAD(P) binding site [chemical binding]; other site 326424008084 active site 326424008085 Amidohydrolase; Region: Amidohydro_2; pfam04909 326424008086 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 326424008087 pantoate--beta-alanine ligase; Region: panC; TIGR00018 326424008088 active site 326424008089 nucleotide binding site [chemical binding]; other site 326424008090 HIGH motif; other site 326424008091 KMSKS motif; other site 326424008092 enoyl-CoA hydratase; Provisional; Region: PRK08290 326424008093 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424008094 substrate binding site [chemical binding]; other site 326424008095 oxyanion hole (OAH) forming residues; other site 326424008096 trimer interface [polypeptide binding]; other site 326424008097 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 326424008098 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424008099 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 326424008100 acyl-activating enzyme (AAE) consensus motif; other site 326424008101 acyl-activating enzyme (AAE) consensus motif; other site 326424008102 putative AMP binding site [chemical binding]; other site 326424008103 putative active site [active] 326424008104 putative CoA binding site [chemical binding]; other site 326424008105 Isochorismatase family; Region: Isochorismatase; pfam00857 326424008106 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 326424008107 catalytic triad [active] 326424008108 conserved cis-peptide bond; other site 326424008109 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326424008110 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 326424008111 active site 326424008112 metal binding site [ion binding]; metal-binding site 326424008113 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326424008114 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 326424008115 active site 326424008116 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424008117 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424008118 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424008119 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424008120 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424008121 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424008122 active site 326424008123 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 326424008124 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424008125 substrate binding site [chemical binding]; other site 326424008126 oxyanion hole (OAH) forming residues; other site 326424008127 trimer interface [polypeptide binding]; other site 326424008128 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 326424008129 DUF35 OB-fold domain; Region: DUF35; pfam01796 326424008130 lipid-transfer protein; Provisional; Region: PRK07855 326424008131 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 326424008132 active site 326424008133 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 326424008134 putative active site [active] 326424008135 putative catalytic site [active] 326424008136 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 326424008137 CoA-transferase family III; Region: CoA_transf_3; pfam02515 326424008138 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 326424008139 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424008140 acyl-activating enzyme (AAE) consensus motif; other site 326424008141 AMP binding site [chemical binding]; other site 326424008142 active site 326424008143 CoA binding site [chemical binding]; other site 326424008144 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424008145 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424008146 Amidohydrolase; Region: Amidohydro_2; pfam04909 326424008147 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 326424008148 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424008149 Amidohydrolase; Region: Amidohydro_2; pfam04909 326424008150 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 326424008151 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 326424008152 iron-sulfur cluster [ion binding]; other site 326424008153 [2Fe-2S] cluster binding site [ion binding]; other site 326424008154 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424008155 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424008156 active site 326424008157 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424008158 DUF35 OB-fold domain; Region: DUF35; pfam01796 326424008159 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 326424008160 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 326424008161 active site 326424008162 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 326424008163 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 326424008164 active site 326424008165 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 326424008166 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424008167 Walker A/P-loop; other site 326424008168 ATP binding site [chemical binding]; other site 326424008169 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326424008170 ABC transporter; Region: ABC_tran_2; pfam12848 326424008171 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424008172 ABC transporter signature motif; other site 326424008173 Walker B; other site 326424008174 D-loop; other site 326424008175 H-loop/switch region; other site 326424008176 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424008177 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424008178 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 326424008179 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 326424008180 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 326424008181 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424008182 acyl-activating enzyme (AAE) consensus motif; other site 326424008183 AMP binding site [chemical binding]; other site 326424008184 active site 326424008185 CoA binding site [chemical binding]; other site 326424008186 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424008187 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 326424008188 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424008189 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424008190 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424008191 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424008192 active site 326424008193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424008194 NAD(P) binding site [chemical binding]; other site 326424008195 active site 326424008196 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 326424008197 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 326424008198 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 326424008199 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 326424008200 active site 326424008201 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424008202 NAD(P) binding site [chemical binding]; other site 326424008203 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 326424008204 active site 326424008205 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 326424008206 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 326424008207 active site 2 [active] 326424008208 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 326424008209 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424008210 acyl-activating enzyme (AAE) consensus motif; other site 326424008211 AMP binding site [chemical binding]; other site 326424008212 active site 326424008213 CoA binding site [chemical binding]; other site 326424008214 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 326424008215 CoA-transferase family III; Region: CoA_transf_3; pfam02515 326424008216 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 326424008217 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424008218 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424008219 Amidohydrolase; Region: Amidohydro_2; pfam04909 326424008220 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 326424008221 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 326424008222 putative ligand binding site [chemical binding]; other site 326424008223 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424008224 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 326424008225 NAD(P) binding site [chemical binding]; other site 326424008226 active site 326424008227 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 326424008228 TM-ABC transporter signature motif; other site 326424008229 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 326424008230 TM-ABC transporter signature motif; other site 326424008231 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 326424008232 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 326424008233 Walker A/P-loop; other site 326424008234 ATP binding site [chemical binding]; other site 326424008235 Q-loop/lid; other site 326424008236 ABC transporter signature motif; other site 326424008237 Walker B; other site 326424008238 D-loop; other site 326424008239 H-loop/switch region; other site 326424008240 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 326424008241 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 326424008242 Walker A/P-loop; other site 326424008243 ATP binding site [chemical binding]; other site 326424008244 Q-loop/lid; other site 326424008245 ABC transporter signature motif; other site 326424008246 Walker B; other site 326424008247 D-loop; other site 326424008248 H-loop/switch region; other site 326424008249 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 326424008250 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 326424008251 putative ligand binding site [chemical binding]; other site 326424008252 Transcriptional regulators [Transcription]; Region: FadR; COG2186 326424008253 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326424008254 DNA-binding site [nucleotide binding]; DNA binding site 326424008255 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 326424008256 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 326424008257 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 326424008258 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 326424008259 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 326424008260 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 326424008261 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424008262 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441 326424008263 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424008264 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424008265 active site 326424008266 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 326424008267 CoA-transferase family III; Region: CoA_transf_3; pfam02515 326424008268 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 326424008269 classical (c) SDRs; Region: SDR_c; cd05233 326424008270 NAD(P) binding site [chemical binding]; other site 326424008271 active site 326424008272 classical (c) SDRs; Region: SDR_c; cd05233 326424008273 NAD(P) binding site [chemical binding]; other site 326424008274 active site 326424008275 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 326424008276 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424008277 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424008278 NAD(P) binding site [chemical binding]; other site 326424008279 active site 326424008280 Predicted transcriptional regulators [Transcription]; Region: COG1733 326424008281 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 326424008282 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424008283 substrate binding site [chemical binding]; other site 326424008284 oxyanion hole (OAH) forming residues; other site 326424008285 trimer interface [polypeptide binding]; other site 326424008286 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 326424008287 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 326424008288 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424008289 RibD C-terminal domain; Region: RibD_C; cl17279 326424008290 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 326424008291 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 326424008292 AzlC protein; Region: AzlC; pfam03591 326424008293 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424008294 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424008295 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424008296 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424008297 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 326424008298 classical (c) SDRs; Region: SDR_c; cd05233 326424008299 NAD(P) binding site [chemical binding]; other site 326424008300 active site 326424008301 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 326424008302 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 326424008303 NAD binding site [chemical binding]; other site 326424008304 catalytic residues [active] 326424008305 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 326424008306 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424008307 AMP binding site [chemical binding]; other site 326424008308 active site 326424008309 acyl-activating enzyme (AAE) consensus motif; other site 326424008310 CoA binding site [chemical binding]; other site 326424008311 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 326424008312 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 326424008313 putative ligand binding site [chemical binding]; other site 326424008314 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 326424008315 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 326424008316 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 326424008317 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424008318 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424008319 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424008320 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424008321 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424008322 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424008323 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 326424008324 putative active site [active] 326424008325 putative substrate binding site [chemical binding]; other site 326424008326 ATP binding site [chemical binding]; other site 326424008327 Ecdysteroid kinase; Region: EcKinase; cl17738 326424008328 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 326424008329 classical (c) SDRs; Region: SDR_c; cd05233 326424008330 NAD(P) binding site [chemical binding]; other site 326424008331 active site 326424008332 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424008333 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424008334 active site 326424008335 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424008336 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424008337 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424008338 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424008339 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 326424008340 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 326424008341 catalytic residue [active] 326424008342 putative FPP diphosphate binding site; other site 326424008343 putative FPP binding hydrophobic cleft; other site 326424008344 dimer interface [polypeptide binding]; other site 326424008345 putative IPP diphosphate binding site; other site 326424008346 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 326424008347 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 326424008348 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424008349 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424008350 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 326424008351 mycofactocin precursor; Region: mycofactocin; TIGR03969 326424008352 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 326424008353 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 326424008354 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326424008355 FeS/SAM binding site; other site 326424008356 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 326424008357 Predicted transcriptional regulators [Transcription]; Region: COG1733 326424008358 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 326424008359 Uncharacterized conserved protein [Function unknown]; Region: COG2353 326424008360 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 326424008361 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 326424008362 phosphate binding site [ion binding]; other site 326424008363 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 326424008364 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 326424008365 putative ligand binding site [chemical binding]; other site 326424008366 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 326424008367 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 326424008368 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326424008369 motif II; other site 326424008370 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 326424008371 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 326424008372 active site 326424008373 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 326424008374 CoA-transferase family III; Region: CoA_transf_3; pfam02515 326424008375 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 326424008376 CoA-transferase family III; Region: CoA_transf_3; pfam02515 326424008377 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 326424008378 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 326424008379 putative active site [active] 326424008380 putative dimer interface [polypeptide binding]; other site 326424008381 PAS domain; Region: PAS_9; pfam13426 326424008382 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 326424008383 putative active site [active] 326424008384 heme pocket [chemical binding]; other site 326424008385 PAS domain S-box; Region: sensory_box; TIGR00229 326424008386 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 326424008387 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 326424008388 metal binding site [ion binding]; metal-binding site 326424008389 active site 326424008390 I-site; other site 326424008391 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 326424008392 MarR family; Region: MarR; pfam01047 326424008393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424008394 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326424008395 putative substrate translocation pore; other site 326424008396 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 326424008397 Ligand Binding Site [chemical binding]; other site 326424008398 PPOX class probable F420-dependent enzyme, MSMEG_5819 family; Region: PPOX_MSMEG_5819; TIGR04023 326424008399 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 326424008400 CoA-transferase family III; Region: CoA_transf_3; pfam02515 326424008401 SnoaL-like domain; Region: SnoaL_2; pfam12680 326424008402 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326424008403 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 326424008404 dimerization interface [polypeptide binding]; other site 326424008405 shikimate kinase; Reviewed; Region: aroK; PRK00131 326424008406 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 326424008407 ADP binding site [chemical binding]; other site 326424008408 magnesium binding site [ion binding]; other site 326424008409 putative shikimate binding site; other site 326424008410 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 326424008411 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 326424008412 DUF35 OB-fold domain; Region: DUF35; pfam01796 326424008413 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 326424008414 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326424008415 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 326424008416 MarR family; Region: MarR_2; pfam12802 326424008417 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424008418 NAD(P) binding site [chemical binding]; other site 326424008419 active site 326424008420 Transcriptional regulators [Transcription]; Region: MarR; COG1846 326424008421 MarR family; Region: MarR; pfam01047 326424008422 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 326424008423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424008424 putative substrate translocation pore; other site 326424008425 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 326424008426 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 326424008427 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 326424008428 NB-ARC domain; Region: NB-ARC; pfam00931 326424008429 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 326424008430 structural tetrad; other site 326424008431 FOG: WD40 repeat [General function prediction only]; Region: COG2319 326424008432 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 326424008433 structural tetrad; other site 326424008434 classical (c) SDRs; Region: SDR_c; cd05233 326424008435 NAD(P) binding site [chemical binding]; other site 326424008436 active site 326424008437 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424008438 NAD(P) binding site [chemical binding]; other site 326424008439 active site 326424008440 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424008441 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 326424008442 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424008443 Walker A/P-loop; other site 326424008444 ATP binding site [chemical binding]; other site 326424008445 Q-loop/lid; other site 326424008446 ABC transporter signature motif; other site 326424008447 Walker B; other site 326424008448 D-loop; other site 326424008449 H-loop/switch region; other site 326424008450 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 326424008451 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 326424008452 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 326424008453 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 326424008454 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326424008455 active site 326424008456 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326424008457 dimerization interface [polypeptide binding]; other site 326424008458 putative DNA binding site [nucleotide binding]; other site 326424008459 putative Zn2+ binding site [ion binding]; other site 326424008460 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 326424008461 Anti-sigma-K factor rskA; Region: RskA; pfam10099 326424008462 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 326424008463 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326424008464 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 326424008465 DNA binding residues [nucleotide binding] 326424008466 Protein of unknown function (DUF692); Region: DUF692; cl01263 326424008467 Methyltransferase domain; Region: Methyltransf_31; pfam13847 326424008468 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424008469 S-adenosylmethionine binding site [chemical binding]; other site 326424008470 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 326424008471 nudix motif; other site 326424008472 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424008473 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 326424008474 NAD(P) binding site [chemical binding]; other site 326424008475 active site 326424008476 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424008477 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326424008478 salt bridge; other site 326424008479 non-specific DNA binding site [nucleotide binding]; other site 326424008480 sequence-specific DNA binding site [nucleotide binding]; other site 326424008481 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424008482 S-adenosylmethionine binding site [chemical binding]; other site 326424008483 Beta-lactamase; Region: Beta-lactamase; pfam00144 326424008484 short chain dehydrogenase; Provisional; Region: PRK06180 326424008485 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 326424008486 NADP binding site [chemical binding]; other site 326424008487 active site 326424008488 steroid binding site; other site 326424008489 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 326424008490 MarR family; Region: MarR; pfam01047 326424008491 SnoaL-like domain; Region: SnoaL_2; pfam12680 326424008492 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326424008493 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326424008494 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 326424008495 putative acetyltransferase; Provisional; Region: PRK03624 326424008496 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326424008497 Coenzyme A binding pocket [chemical binding]; other site 326424008498 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 326424008499 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 326424008500 dimer interface [polypeptide binding]; other site 326424008501 active site 326424008502 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424008503 FtsX-like permease family; Region: FtsX; pfam02687 326424008504 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 326424008505 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 326424008506 Walker A/P-loop; other site 326424008507 ATP binding site [chemical binding]; other site 326424008508 Q-loop/lid; other site 326424008509 ABC transporter signature motif; other site 326424008510 Walker B; other site 326424008511 D-loop; other site 326424008512 H-loop/switch region; other site 326424008513 Predicted transcriptional regulators [Transcription]; Region: COG1695 326424008514 Transcriptional regulator PadR-like family; Region: PadR; cl17335 326424008515 Epoxide hydrolase N terminus; Region: EHN; pfam06441 326424008516 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 326424008517 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 326424008518 MOSC domain; Region: MOSC; pfam03473 326424008519 amidase; Provisional; Region: PRK06170 326424008520 Amidase; Region: Amidase; cl11426 326424008521 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 326424008522 classical (c) SDRs; Region: SDR_c; cd05233 326424008523 NAD(P) binding site [chemical binding]; other site 326424008524 active site 326424008525 Predicted transcriptional regulators [Transcription]; Region: COG1695 326424008526 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 326424008527 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 326424008528 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 326424008529 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 326424008530 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 326424008531 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 326424008532 active site 326424008533 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 326424008534 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 326424008535 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 326424008536 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 326424008537 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 326424008538 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 326424008539 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 326424008540 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424008541 Walker A/P-loop; other site 326424008542 ATP binding site [chemical binding]; other site 326424008543 Q-loop/lid; other site 326424008544 ABC transporter signature motif; other site 326424008545 Walker B; other site 326424008546 D-loop; other site 326424008547 H-loop/switch region; other site 326424008548 Penicillinase repressor; Region: Pencillinase_R; cl17580 326424008549 Peptidase family M48; Region: Peptidase_M48; cl12018 326424008550 5,10-methylenetetrahydrofolate reductase [Amino acid transport and metabolism]; Region: MetF; COG0685 326424008551 FAD binding site [chemical binding]; other site 326424008552 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 326424008553 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 326424008554 putative NAD(P) binding site [chemical binding]; other site 326424008555 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326424008556 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 326424008557 Coenzyme A binding pocket [chemical binding]; other site 326424008558 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 326424008559 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 326424008560 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 326424008561 Methyltransferase domain; Region: Methyltransf_11; pfam08241 326424008562 RibD C-terminal domain; Region: RibD_C; cl17279 326424008563 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 326424008564 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 326424008565 DNA binding residues [nucleotide binding] 326424008566 drug binding residues [chemical binding]; other site 326424008567 dimer interface [polypeptide binding]; other site 326424008568 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 326424008569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424008570 Methyltransferase domain; Region: Methyltransf_23; pfam13489 326424008571 S-adenosylmethionine binding site [chemical binding]; other site 326424008572 Helix-turn-helix domain; Region: HTH_18; pfam12833 326424008573 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 326424008574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424008575 Methyltransferase domain; Region: Methyltransf_23; pfam13489 326424008576 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424008577 S-adenosylmethionine binding site [chemical binding]; other site 326424008578 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424008579 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424008580 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 326424008581 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326424008582 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 326424008583 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 326424008584 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 326424008585 CrcB-like protein; Region: CRCB; pfam02537 326424008586 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 326424008587 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 326424008588 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 326424008589 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 326424008590 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 326424008591 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 326424008592 catalytic residues [active] 326424008593 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 326424008594 Zn2+ binding site [ion binding]; other site 326424008595 Mg2+ binding site [ion binding]; other site 326424008596 amino acid transporter; Region: 2A0306; TIGR00909 326424008597 amino acid transporter; Region: 2A0306; TIGR00909 326424008598 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 326424008599 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 326424008600 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 326424008601 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 326424008602 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 326424008603 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 326424008604 active site 326424008605 DNA binding site [nucleotide binding] 326424008606 Int/Topo IB signature motif; other site 326424008607 TIR domain; Region: TIR_2; cl17458 326424008608 FOG: WD40 repeat [General function prediction only]; Region: COG2319 326424008609 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 326424008610 structural tetrad; other site 326424008611 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 326424008612 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 326424008613 Uncharacterized conserved protein [Function unknown]; Region: COG1262 326424008614 Phosphotransferase enzyme family; Region: APH; pfam01636 326424008615 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 326424008616 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 326424008617 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 326424008618 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 326424008619 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 326424008620 metal ion-dependent adhesion site (MIDAS); other site 326424008621 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 326424008622 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 326424008623 homodimer interface [polypeptide binding]; other site 326424008624 Walker A motif; other site 326424008625 ATP binding site [chemical binding]; other site 326424008626 hydroxycobalamin binding site [chemical binding]; other site 326424008627 Walker B motif; other site 326424008628 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 326424008629 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 326424008630 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 326424008631 conserved cys residue [active] 326424008632 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 326424008633 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 326424008634 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 326424008635 extended (e) SDRs; Region: SDR_e; cd08946 326424008636 NAD(P) binding site [chemical binding]; other site 326424008637 active site 326424008638 substrate binding site [chemical binding]; other site 326424008639 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424008640 Precorrin-8X methylmutase; Region: CbiC; pfam02570 326424008641 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 326424008642 YCII-related domain; Region: YCII; cl00999 326424008643 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326424008644 dimerization interface [polypeptide binding]; other site 326424008645 putative DNA binding site [nucleotide binding]; other site 326424008646 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 326424008647 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 326424008648 active site 326424008649 Epoxide hydrolase N terminus; Region: EHN; pfam06441 326424008650 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 326424008651 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326424008652 Coenzyme A binding pocket [chemical binding]; other site 326424008653 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424008654 ABC transporter signature motif; other site 326424008655 Predicted transcriptional regulators [Transcription]; Region: COG1725 326424008656 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 326424008657 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326424008658 DNA-binding site [nucleotide binding]; DNA binding site 326424008659 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 326424008660 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 326424008661 Walker A/P-loop; other site 326424008662 ATP binding site [chemical binding]; other site 326424008663 Q-loop/lid; other site 326424008664 ABC transporter signature motif; other site 326424008665 Walker B; other site 326424008666 D-loop; other site 326424008667 H-loop/switch region; other site 326424008668 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 326424008669 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 326424008670 Phosphotransferase enzyme family; Region: APH; pfam01636 326424008671 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 326424008672 active site 326424008673 ATP binding site [chemical binding]; other site 326424008674 substrate binding site [chemical binding]; other site 326424008675 TM2 domain; Region: TM2; cl00984 326424008676 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 326424008677 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 326424008678 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 326424008679 putative acyl-acceptor binding pocket; other site 326424008680 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 326424008681 fatty acyl-CoA reductase; Region: PLN02996 326424008682 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424008683 NAD(P) binding site [chemical binding]; other site 326424008684 active site 326424008685 C-terminal domain of fatty acyl CoA reductases; Region: FAR_C; cl03838 326424008686 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 326424008687 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 326424008688 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 326424008689 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 326424008690 active site 326424008691 putative 5' ssDNA interaction site; other site 326424008692 metal binding site 3; metal-binding site 326424008693 metal binding site 1 [ion binding]; metal-binding site 326424008694 metal binding site 2 [ion binding]; metal-binding site 326424008695 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 326424008696 putative DNA binding site [nucleotide binding]; other site 326424008697 putative metal binding site [ion binding]; other site 326424008698 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326424008699 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 326424008700 putative DNA binding site [nucleotide binding]; other site 326424008701 putative Zn2+ binding site [ion binding]; other site 326424008702 AsnC family; Region: AsnC_trans_reg; pfam01037 326424008703 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 326424008704 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 326424008705 Walker A/P-loop; other site 326424008706 ATP binding site [chemical binding]; other site 326424008707 Q-loop/lid; other site 326424008708 ABC transporter signature motif; other site 326424008709 Walker B; other site 326424008710 D-loop; other site 326424008711 H-loop/switch region; other site 326424008712 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 326424008713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424008714 dimer interface [polypeptide binding]; other site 326424008715 conserved gate region; other site 326424008716 putative PBP binding loops; other site 326424008717 ABC-ATPase subunit interface; other site 326424008718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424008719 dimer interface [polypeptide binding]; other site 326424008720 conserved gate region; other site 326424008721 putative PBP binding loops; other site 326424008722 ABC-ATPase subunit interface; other site 326424008723 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 326424008724 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 326424008725 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 326424008726 active site 326424008727 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 326424008728 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 326424008729 putative active site [active] 326424008730 catalytic triad [active] 326424008731 putative dimer interface [polypeptide binding]; other site 326424008732 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 326424008733 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 326424008734 Ligand binding site; other site 326424008735 Putative Catalytic site; other site 326424008736 DXD motif; other site 326424008737 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 326424008738 methionine sulfoxide reductase B; Provisional; Region: PRK00222 326424008739 SelR domain; Region: SelR; pfam01641 326424008740 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 326424008741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 326424008742 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 326424008743 active site 326424008744 ATP binding site [chemical binding]; other site 326424008745 substrate binding site [chemical binding]; other site 326424008746 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 326424008747 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424008748 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 326424008749 active site 326424008750 DNA binding site [nucleotide binding] 326424008751 catalytic site [active] 326424008752 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 326424008753 Fatty acid desaturase; Region: FA_desaturase; pfam00487 326424008754 Di-iron ligands [ion binding]; other site 326424008755 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326424008756 ATP binding site [chemical binding]; other site 326424008757 putative Mg++ binding site [ion binding]; other site 326424008758 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326424008759 nucleotide binding region [chemical binding]; other site 326424008760 ATP-binding site [chemical binding]; other site 326424008761 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 326424008762 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424008763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424008764 active site 326424008765 phosphorylation site [posttranslational modification] 326424008766 intermolecular recognition site; other site 326424008767 dimerization interface [polypeptide binding]; other site 326424008768 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326424008769 DNA binding residues [nucleotide binding] 326424008770 dimerization interface [polypeptide binding]; other site 326424008771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 326424008772 AAA domain; Region: AAA_33; pfam13671 326424008773 TM2 domain; Region: TM2; pfam05154 326424008774 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 326424008775 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 326424008776 active site 326424008777 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 326424008778 active site 326424008779 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 326424008780 active site flap/lid [active] 326424008781 nucleophilic elbow; other site 326424008782 catalytic triad [active] 326424008783 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 326424008784 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424008785 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 326424008786 short chain dehydrogenase; Provisional; Region: PRK07791 326424008787 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424008788 NAD(P) binding site [chemical binding]; other site 326424008789 active site 326424008790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424008791 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 326424008792 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 326424008793 XdhC Rossmann domain; Region: XdhC_C; pfam13478 326424008794 enoyl-CoA hydratase; Provisional; Region: PRK08252 326424008795 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424008796 substrate binding site [chemical binding]; other site 326424008797 oxyanion hole (OAH) forming residues; other site 326424008798 trimer interface [polypeptide binding]; other site 326424008799 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 326424008800 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 326424008801 putative ligand binding site [chemical binding]; other site 326424008802 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 326424008803 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 326424008804 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 326424008805 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 326424008806 Part of AAA domain; Region: AAA_19; pfam13245 326424008807 Family description; Region: UvrD_C_2; pfam13538 326424008808 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424008809 PBP superfamily domain; Region: PBP_like_2; cl17296 326424008810 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424008811 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 326424008812 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 326424008813 zinc binding site [ion binding]; other site 326424008814 putative ligand binding site [chemical binding]; other site 326424008815 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 326424008816 TM-ABC transporter signature motif; other site 326424008817 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 326424008818 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424008819 Walker A/P-loop; other site 326424008820 ATP binding site [chemical binding]; other site 326424008821 Q-loop/lid; other site 326424008822 ABC transporter signature motif; other site 326424008823 Walker B; other site 326424008824 D-loop; other site 326424008825 H-loop/switch region; other site 326424008826 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 326424008827 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 326424008828 active site 326424008829 substrate binding site [chemical binding]; other site 326424008830 FMN binding site [chemical binding]; other site 326424008831 putative catalytic residues [active] 326424008832 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 326424008833 homotrimer interaction site [polypeptide binding]; other site 326424008834 putative active site [active] 326424008835 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326424008836 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 326424008837 active site 326424008838 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 326424008839 NADH(P)-binding; Region: NAD_binding_10; pfam13460 326424008840 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424008841 NAD(P) binding site [chemical binding]; other site 326424008842 active site 326424008843 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 326424008844 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326424008845 phosphorylation site [posttranslational modification] 326424008846 dimer interface [polypeptide binding]; other site 326424008847 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424008848 ATP binding site [chemical binding]; other site 326424008849 Mg2+ binding site [ion binding]; other site 326424008850 G-X-G motif; other site 326424008851 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326424008852 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424008853 active site 326424008854 phosphorylation site [posttranslational modification] 326424008855 intermolecular recognition site; other site 326424008856 dimerization interface [polypeptide binding]; other site 326424008857 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326424008858 DNA binding site [nucleotide binding] 326424008859 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 326424008860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424008861 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424008862 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424008863 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 326424008864 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 326424008865 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 326424008866 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 326424008867 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 326424008868 Cytochrome P450; Region: p450; cl12078 326424008869 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 326424008870 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424008871 Walker A/P-loop; other site 326424008872 ATP binding site [chemical binding]; other site 326424008873 Q-loop/lid; other site 326424008874 ABC transporter signature motif; other site 326424008875 Walker B; other site 326424008876 D-loop; other site 326424008877 H-loop/switch region; other site 326424008878 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 326424008879 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 326424008880 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 326424008881 Walker A/P-loop; other site 326424008882 ATP binding site [chemical binding]; other site 326424008883 Q-loop/lid; other site 326424008884 ABC transporter signature motif; other site 326424008885 Walker B; other site 326424008886 D-loop; other site 326424008887 H-loop/switch region; other site 326424008888 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 326424008889 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 326424008890 putative ligand binding site [chemical binding]; other site 326424008891 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 326424008892 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 326424008893 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 326424008894 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 326424008895 Leucine carboxyl methyltransferase; Region: LCM; cl01306 326424008896 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 326424008897 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 326424008898 RNA/DNA hybrid binding site [nucleotide binding]; other site 326424008899 active site 326424008900 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 326424008901 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 326424008902 AsnC family; Region: AsnC_trans_reg; pfam01037 326424008903 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 326424008904 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 326424008905 DUF35 OB-fold domain; Region: DUF35; pfam01796 326424008906 lipid-transfer protein; Provisional; Region: PRK08256 326424008907 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 326424008908 active site 326424008909 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424008910 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424008911 oxidoreductase; Provisional; Region: PRK06196 326424008912 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 326424008913 putative NAD(P) binding site [chemical binding]; other site 326424008914 active site 326424008915 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424008916 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424008917 active site 326424008918 ATP binding site [chemical binding]; other site 326424008919 substrate binding site [chemical binding]; other site 326424008920 activation loop (A-loop); other site 326424008921 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 326424008922 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 326424008923 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 326424008924 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 326424008925 putative NAD(P) binding site [chemical binding]; other site 326424008926 putative substrate binding site [chemical binding]; other site 326424008927 catalytic Zn binding site [ion binding]; other site 326424008928 structural Zn binding site [ion binding]; other site 326424008929 dimer interface [polypeptide binding]; other site 326424008930 4Fe-4S binding domain; Region: Fer4; pfam00037 326424008931 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 326424008932 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 326424008933 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 326424008934 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 326424008935 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 326424008936 H+ Antiporter protein; Region: 2A0121; TIGR00900 326424008937 FAD binding domain; Region: FAD_binding_4; pfam01565 326424008938 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 326424008939 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 326424008940 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 326424008941 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 326424008942 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 326424008943 active site residue [active] 326424008944 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 326424008945 active site residue [active] 326424008946 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 326424008947 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326424008948 Walker A/P-loop; other site 326424008949 ATP binding site [chemical binding]; other site 326424008950 Q-loop/lid; other site 326424008951 ABC transporter signature motif; other site 326424008952 Walker B; other site 326424008953 D-loop; other site 326424008954 H-loop/switch region; other site 326424008955 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 326424008956 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326424008957 Walker A/P-loop; other site 326424008958 ATP binding site [chemical binding]; other site 326424008959 Q-loop/lid; other site 326424008960 ABC transporter signature motif; other site 326424008961 Walker B; other site 326424008962 D-loop; other site 326424008963 H-loop/switch region; other site 326424008964 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 326424008965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424008966 dimer interface [polypeptide binding]; other site 326424008967 conserved gate region; other site 326424008968 putative PBP binding loops; other site 326424008969 ABC-ATPase subunit interface; other site 326424008970 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 326424008971 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424008972 dimer interface [polypeptide binding]; other site 326424008973 conserved gate region; other site 326424008974 ABC-ATPase subunit interface; other site 326424008975 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 326424008976 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 326424008977 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424008978 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424008979 active site 326424008980 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 326424008981 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 326424008982 dimer interface [polypeptide binding]; other site 326424008983 active site 326424008984 non-prolyl cis peptide bond; other site 326424008985 insertion regions; other site 326424008986 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 326424008987 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 326424008988 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326424008989 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326424008990 LysR substrate binding domain; Region: LysR_substrate; pfam03466 326424008991 dimerization interface [polypeptide binding]; other site 326424008992 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 326424008993 GAF domain; Region: GAF; pfam01590 326424008994 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 326424008995 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424008996 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424008997 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424008998 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424008999 active site 326424009000 Phosphotransferase enzyme family; Region: APH; pfam01636 326424009001 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 326424009002 active site 326424009003 ATP binding site [chemical binding]; other site 326424009004 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 326424009005 CoA-transferase family III; Region: CoA_transf_3; pfam02515 326424009006 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 326424009007 CoA-transferase family III; Region: CoA_transf_3; pfam02515 326424009008 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424009009 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424009010 active site 326424009011 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424009012 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 326424009013 active site 326424009014 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424009015 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424009016 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 326424009017 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 326424009018 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 326424009019 EamA-like transporter family; Region: EamA; pfam00892 326424009020 EamA-like transporter family; Region: EamA; pfam00892 326424009021 hypothetical protein; Provisional; Region: PRK06815 326424009022 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 326424009023 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326424009024 catalytic residue [active] 326424009025 Phosphotransferase enzyme family; Region: APH; pfam01636 326424009026 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 326424009027 active site 326424009028 substrate binding site [chemical binding]; other site 326424009029 ATP binding site [chemical binding]; other site 326424009030 Fatty acid desaturase; Region: FA_desaturase; pfam00487 326424009031 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 326424009032 putative di-iron ligands [ion binding]; other site 326424009033 GAF domain; Region: GAF; pfam01590 326424009034 GAF domain; Region: GAF_2; pfam13185 326424009035 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 326424009036 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 326424009037 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 326424009038 anti sigma factor interaction site; other site 326424009039 regulatory phosphorylation site [posttranslational modification]; other site 326424009040 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 326424009041 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 326424009042 heme binding pocket [chemical binding]; other site 326424009043 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 326424009044 domain interactions; other site 326424009045 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 326424009046 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 326424009047 substrate binding pocket [chemical binding]; other site 326424009048 membrane-bound complex binding site; other site 326424009049 hinge residues; other site 326424009050 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424009051 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424009052 active site 326424009053 ATP binding site [chemical binding]; other site 326424009054 substrate binding site [chemical binding]; other site 326424009055 activation loop (A-loop); other site 326424009056 Tetratricopeptide repeat; Region: TPR_16; pfam13432 326424009057 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 326424009058 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 326424009059 metal ion-dependent adhesion site (MIDAS); other site 326424009060 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 326424009061 phosphopeptide binding site; other site 326424009062 TIR domain; Region: TIR_2; pfam13676 326424009063 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424009064 Tetratricopeptide repeat; Region: TPR_10; pfam13374 326424009065 Predicted transcriptional regulator [Transcription]; Region: COG2378 326424009066 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326424009067 putative Zn2+ binding site [ion binding]; other site 326424009068 putative DNA binding site [nucleotide binding]; other site 326424009069 WYL domain; Region: WYL; pfam13280 326424009070 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 326424009071 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 326424009072 Transcription factor WhiB; Region: Whib; pfam02467 326424009073 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 326424009074 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 326424009075 active site 326424009076 DNA binding site [nucleotide binding] 326424009077 Int/Topo IB signature motif; other site 326424009078 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 326424009079 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 326424009080 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 326424009081 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 326424009082 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 326424009083 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424009084 Walker A/P-loop; other site 326424009085 ATP binding site [chemical binding]; other site 326424009086 Q-loop/lid; other site 326424009087 ABC transporter signature motif; other site 326424009088 Walker B; other site 326424009089 D-loop; other site 326424009090 H-loop/switch region; other site 326424009091 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 326424009092 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 326424009093 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 326424009094 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 326424009095 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 326424009096 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 326424009097 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 326424009098 nudix motif; other site 326424009099 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 326424009100 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 326424009101 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 326424009102 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 326424009103 hydrophobic ligand binding site; other site 326424009104 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 326424009105 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 326424009106 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 326424009107 GAF domain; Region: GAF; pfam01590 326424009108 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 326424009109 MMPL family; Region: MMPL; pfam03176 326424009110 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 326424009111 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 326424009112 Cytochrome P450; Region: p450; cl12078 326424009113 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 326424009114 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 326424009115 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 326424009116 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 326424009117 active site 326424009118 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 326424009119 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 326424009120 substrate binding site [chemical binding]; other site 326424009121 ATP binding site [chemical binding]; other site 326424009122 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 326424009123 active site 326424009124 nucleotide binding site [chemical binding]; other site 326424009125 HIGH motif; other site 326424009126 KMSKS motif; other site 326424009127 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 326424009128 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 326424009129 putative active site [active] 326424009130 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 326424009131 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326424009132 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 326424009133 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 326424009134 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 326424009135 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326424009136 active site 326424009137 motif I; other site 326424009138 motif II; other site 326424009139 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 326424009140 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 326424009141 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 326424009142 putative active site [active] 326424009143 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 326424009144 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 326424009145 putative ADP-binding pocket [chemical binding]; other site 326424009146 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 326424009147 active site 326424009148 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 326424009149 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 326424009150 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 326424009151 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 326424009152 active site 326424009153 HIGH motif; other site 326424009154 nucleotide binding site [chemical binding]; other site 326424009155 classical (c) SDRs; Region: SDR_c; cd05233 326424009156 NAD(P) binding site [chemical binding]; other site 326424009157 active site 326424009158 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 326424009159 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 326424009160 TIR domain; Region: TIR_2; pfam13676 326424009161 YheO-like PAS domain; Region: PAS_6; pfam08348 326424009162 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 326424009163 FOG: CBS domain [General function prediction only]; Region: COG0517 326424009164 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 326424009165 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 326424009166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424009167 putative substrate translocation pore; other site 326424009168 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424009169 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424009170 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 326424009171 active site 326424009172 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 326424009173 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 326424009174 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 326424009175 putative hydrophobic ligand binding site [chemical binding]; other site 326424009176 Phosphotransferase enzyme family; Region: APH; pfam01636 326424009177 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 326424009178 active site 326424009179 ATP binding site [chemical binding]; other site 326424009180 substrate binding site [chemical binding]; other site 326424009181 ApbE family; Region: ApbE; pfam02424 326424009182 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 326424009183 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 326424009184 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 326424009185 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 326424009186 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 326424009187 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 326424009188 TIR domain; Region: TIR_2; pfam13676 326424009189 NACHT domain; Region: NACHT; pfam05729 326424009190 FOG: WD40 repeat [General function prediction only]; Region: COG2319 326424009191 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 326424009192 structural tetrad; other site 326424009193 FOG: WD40 repeat [General function prediction only]; Region: COG2319 326424009194 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 326424009195 structural tetrad; other site 326424009196 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 326424009197 structural tetrad; other site 326424009198 classical (c) SDRs; Region: SDR_c; cd05233 326424009199 NAD(P) binding site [chemical binding]; other site 326424009200 active site 326424009201 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424009202 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424009203 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 326424009204 active site 326424009205 metal binding site [ion binding]; metal-binding site 326424009206 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 326424009207 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 326424009208 protein binding site [polypeptide binding]; other site 326424009209 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 326424009210 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 326424009211 substrate binding site [chemical binding]; other site 326424009212 dimer interface [polypeptide binding]; other site 326424009213 ATP binding site [chemical binding]; other site 326424009214 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 326424009215 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424009216 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 326424009217 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 326424009218 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424009219 substrate binding site [chemical binding]; other site 326424009220 oxyanion hole (OAH) forming residues; other site 326424009221 trimer interface [polypeptide binding]; other site 326424009222 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 326424009223 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 326424009224 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 326424009225 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424009226 NAD(P) binding site [chemical binding]; other site 326424009227 classical (c) SDRs; Region: SDR_c; cd05233 326424009228 active site 326424009229 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326424009230 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326424009231 active site 326424009232 catalytic tetrad [active] 326424009233 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 326424009234 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 326424009235 dimer interface [polypeptide binding]; other site 326424009236 active site 326424009237 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424009238 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 326424009239 NAD(P) binding site [chemical binding]; other site 326424009240 active site 326424009241 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 326424009242 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 326424009243 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424009244 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424009245 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424009246 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424009247 active site 326424009248 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424009249 tetracycline repressor protein TetR; Provisional; Region: PRK13756 326424009250 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 326424009251 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 326424009252 active site 326424009253 metal binding site [ion binding]; metal-binding site 326424009254 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 326424009255 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 326424009256 intersubunit interface [polypeptide binding]; other site 326424009257 Excalibur calcium-binding domain; Region: Excalibur; smart00894 326424009258 Excalibur calcium-binding domain; Region: Excalibur; smart00894 326424009259 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 326424009260 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 326424009261 substrate binding site [chemical binding]; other site 326424009262 Transcriptional regulators [Transcription]; Region: GntR; COG1802 326424009263 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326424009264 DNA-binding site [nucleotide binding]; DNA binding site 326424009265 FCD domain; Region: FCD; pfam07729 326424009266 heat shock protein 90; Provisional; Region: PRK05218 326424009267 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424009268 ATP binding site [chemical binding]; other site 326424009269 Mg2+ binding site [ion binding]; other site 326424009270 G-X-G motif; other site 326424009271 TIR domain; Region: TIR_2; pfam13676 326424009272 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424009273 Tetratricopeptide repeat; Region: TPR_10; pfam13374 326424009274 Plant protein of unknown function (DUF946); Region: DUF946; pfam06101 326424009275 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 326424009276 active site 326424009277 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 326424009278 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424009279 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424009280 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 326424009281 similar to hypothetical protein; Evidence 6 : Doubtful CDS 326424009282 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 326424009283 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 326424009284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424009285 putative substrate translocation pore; other site 326424009286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424009287 putative substrate translocation pore; other site 326424009288 Domain of unknown function (DUF222); Region: DUF222; pfam02720 326424009289 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 326424009290 active site 326424009291 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 326424009292 Prostaglandin dehydrogenases; Region: PGDH; cd05288 326424009293 NAD(P) binding site [chemical binding]; other site 326424009294 substrate binding site [chemical binding]; other site 326424009295 dimer interface [polypeptide binding]; other site 326424009296 DinB superfamily; Region: DinB_2; pfam12867 326424009297 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 326424009298 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 326424009299 MarR family; Region: MarR; pfam01047 326424009300 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 326424009301 NADH(P)-binding; Region: NAD_binding_10; pfam13460 326424009302 NAD binding site [chemical binding]; other site 326424009303 substrate binding site [chemical binding]; other site 326424009304 putative active site [active] 326424009305 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424009306 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424009307 WHG domain; Region: WHG; pfam13305 326424009308 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 326424009309 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326424009310 Merozoite surface protein 1 (MSP1) C-terminus; Region: MSP1_C; pfam07462 326424009311 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 326424009312 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 326424009313 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 326424009314 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 326424009315 Cytochrome P450; Region: p450; cl12078 326424009316 alpha-galactosidase; Region: PLN02808; cl17638 326424009317 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326424009318 ATP binding site [chemical binding]; other site 326424009319 putative Mg++ binding site [ion binding]; other site 326424009320 nucleotide binding region [chemical binding]; other site 326424009321 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 326424009322 ATP-binding site [chemical binding]; other site 326424009323 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 326424009324 Uncharacterized conserved protein [Function unknown]; Region: COG2128 326424009325 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 326424009326 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 326424009327 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326424009328 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 326424009329 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424009330 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424009331 active site 326424009332 ATP binding site [chemical binding]; other site 326424009333 substrate binding site [chemical binding]; other site 326424009334 activation loop (A-loop); other site 326424009335 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 326424009336 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 326424009337 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 326424009338 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 326424009339 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424009340 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424009341 active site 326424009342 ATP binding site [chemical binding]; other site 326424009343 substrate binding site [chemical binding]; other site 326424009344 activation loop (A-loop); other site 326424009345 AAA ATPase domain; Region: AAA_16; pfam13191 326424009346 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 326424009347 GAF domain; Region: GAF; pfam01590 326424009348 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 326424009349 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 326424009350 metal binding site [ion binding]; metal-binding site 326424009351 active site 326424009352 I-site; other site 326424009353 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 326424009354 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 326424009355 Domain of unknown function (DUF385); Region: DUF385; cl04387 326424009356 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 326424009357 classical (c) SDRs; Region: SDR_c; cd05233 326424009358 NAD(P) binding site [chemical binding]; other site 326424009359 active site 326424009360 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 326424009361 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 326424009362 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 326424009363 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 326424009364 catalytic residues [active] 326424009365 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 326424009366 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 326424009367 putative dimer interface [polypeptide binding]; other site 326424009368 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 326424009369 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 326424009370 DNA binding residues [nucleotide binding] 326424009371 putative dimer interface [polypeptide binding]; other site 326424009372 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 326424009373 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 326424009374 putative NAD(P) binding site [chemical binding]; other site 326424009375 catalytic Zn binding site [ion binding]; other site 326424009376 short chain dehydrogenase; Provisional; Region: PRK07774 326424009377 classical (c) SDRs; Region: SDR_c; cd05233 326424009378 NAD(P) binding site [chemical binding]; other site 326424009379 active site 326424009380 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 326424009381 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 326424009382 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 326424009383 active site 326424009384 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326424009385 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326424009386 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 326424009387 dimerization interface [polypeptide binding]; other site 326424009388 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 326424009389 active site 326424009390 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424009391 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 326424009392 iron-sulfur cluster [ion binding]; other site 326424009393 [2Fe-2S] cluster binding site [ion binding]; other site 326424009394 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 326424009395 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 326424009396 active site 326424009397 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 326424009398 putative hydrophobic ligand binding site [chemical binding]; other site 326424009399 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 326424009400 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 326424009401 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326424009402 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 326424009403 dimerization interface [polypeptide binding]; other site 326424009404 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326424009405 dimer interface [polypeptide binding]; other site 326424009406 phosphorylation site [posttranslational modification] 326424009407 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424009408 G-X-G motif; other site 326424009409 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326424009410 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424009411 active site 326424009412 phosphorylation site [posttranslational modification] 326424009413 intermolecular recognition site; other site 326424009414 dimerization interface [polypeptide binding]; other site 326424009415 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326424009416 DNA binding site [nucleotide binding] 326424009417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424009418 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326424009419 putative substrate translocation pore; other site 326424009420 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424009421 GAF domain; Region: GAF; pfam01590 326424009422 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 326424009423 Tannase and feruloyl esterase; Region: Tannase; pfam07519 326424009424 Tannase and feruloyl esterase; Region: Tannase; pfam07519 326424009425 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 326424009426 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 326424009427 classical (c) SDRs; Region: SDR_c; cd05233 326424009428 NAD(P) binding site [chemical binding]; other site 326424009429 active site 326424009430 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 326424009431 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 326424009432 active site 326424009433 iron coordination sites [ion binding]; other site 326424009434 substrate binding pocket [chemical binding]; other site 326424009435 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 326424009436 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424009437 NAD(P) binding site [chemical binding]; other site 326424009438 active site 326424009439 hypothetical protein; Provisional; Region: PRK06208 326424009440 intersubunit interface [polypeptide binding]; other site 326424009441 active site 326424009442 Zn2+ binding site [ion binding]; other site 326424009443 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 326424009444 Methyltransferase domain; Region: Methyltransf_23; pfam13489 326424009445 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 326424009446 Phosphotransferase enzyme family; Region: APH; pfam01636 326424009447 active site 326424009448 ATP binding site [chemical binding]; other site 326424009449 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 326424009450 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424009451 S-adenosylmethionine binding site [chemical binding]; other site 326424009452 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 326424009453 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 326424009454 putative ligand binding site [chemical binding]; other site 326424009455 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 326424009456 Acid Phosphatase; Region: Acid_PPase; cl17256 326424009457 Erythronolide synthase docking; Region: Docking; pfam08990 326424009458 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326424009459 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326424009460 active site 326424009461 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 326424009462 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 326424009463 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326424009464 Erythronolide synthase docking; Region: Docking; pfam08990 326424009465 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 326424009466 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326424009467 active site 326424009468 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 326424009469 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326424009470 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326424009471 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 326424009472 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326424009473 active site 326424009474 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 326424009475 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326424009476 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424009477 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 326424009478 Enoylreductase; Region: PKS_ER; smart00829 326424009479 NAD(P) binding site [chemical binding]; other site 326424009480 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 326424009481 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326424009482 putative NADP binding site [chemical binding]; other site 326424009483 active site 326424009484 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326424009485 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326424009486 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326424009487 active site 326424009488 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 326424009489 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 326424009490 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326424009491 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 326424009492 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326424009493 active site 326424009494 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 326424009495 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326424009496 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 326424009497 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326424009498 putative NADP binding site [chemical binding]; other site 326424009499 active site 326424009500 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326424009501 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 326424009502 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326424009503 active site 326424009504 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 326424009505 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326424009506 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 326424009507 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326424009508 putative NADP binding site [chemical binding]; other site 326424009509 active site 326424009510 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326424009511 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 326424009512 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326424009513 active site 326424009514 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 326424009515 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326424009516 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424009517 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 326424009518 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326424009519 putative NADP binding site [chemical binding]; other site 326424009520 active site 326424009521 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326424009522 Thioesterase domain; Region: Thioesterase; pfam00975 326424009523 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 326424009524 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 326424009525 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK06816 326424009526 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 326424009527 active site 326424009528 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 326424009529 DNA binding site [nucleotide binding] 326424009530 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 326424009531 AAA ATPase domain; Region: AAA_16; pfam13191 326424009532 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424009533 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326424009534 DNA binding residues [nucleotide binding] 326424009535 dimerization interface [polypeptide binding]; other site 326424009536 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326424009537 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326424009538 active site 326424009539 catalytic tetrad [active] 326424009540 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 326424009541 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 326424009542 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 326424009543 Cytochrome P450; Region: p450; cl12078 326424009544 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 326424009545 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326424009546 Walker A/P-loop; other site 326424009547 ATP binding site [chemical binding]; other site 326424009548 Q-loop/lid; other site 326424009549 ABC transporter signature motif; other site 326424009550 Walker B; other site 326424009551 D-loop; other site 326424009552 H-loop/switch region; other site 326424009553 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 326424009554 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326424009555 Walker A/P-loop; other site 326424009556 ATP binding site [chemical binding]; other site 326424009557 Q-loop/lid; other site 326424009558 ABC transporter signature motif; other site 326424009559 Walker B; other site 326424009560 D-loop; other site 326424009561 H-loop/switch region; other site 326424009562 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 326424009563 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 326424009564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424009565 putative PBP binding loops; other site 326424009566 ABC-ATPase subunit interface; other site 326424009567 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 326424009568 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424009569 dimer interface [polypeptide binding]; other site 326424009570 conserved gate region; other site 326424009571 putative PBP binding loops; other site 326424009572 ABC-ATPase subunit interface; other site 326424009573 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 326424009574 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 326424009575 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 326424009576 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 326424009577 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 326424009578 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424009579 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 326424009580 Cytochrome P450; Region: p450; cl12078 326424009581 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424009582 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424009583 SnoaL-like domain; Region: SnoaL_4; pfam13577 326424009584 SnoaL-like domain; Region: SnoaL_4; pfam13577 326424009585 SnoaL-like domain; Region: SnoaL_4; pfam13577 326424009586 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 326424009587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424009588 ABC-ATPase subunit interface; other site 326424009589 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 326424009590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424009591 ABC-ATPase subunit interface; other site 326424009592 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 326424009593 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 326424009594 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 326424009595 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 326424009596 active site 326424009597 substrate binding site [chemical binding]; other site 326424009598 putative catalytic residues [active] 326424009599 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 326424009600 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 326424009601 FMN binding site [chemical binding]; other site 326424009602 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424009603 AMP-binding enzyme; Region: AMP-binding; pfam00501 326424009604 acyl-activating enzyme (AAE) consensus motif; other site 326424009605 AMP binding site [chemical binding]; other site 326424009606 active site 326424009607 CoA binding site [chemical binding]; other site 326424009608 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326424009609 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 326424009610 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 326424009611 active site 326424009612 Zn binding site [ion binding]; other site 326424009613 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 326424009614 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 326424009615 Probable Catalytic site; other site 326424009616 metal-binding site 326424009617 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326424009618 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326424009619 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 326424009620 dimerization interface [polypeptide binding]; other site 326424009621 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 326424009622 putative active site [active] 326424009623 putative substrate binding site [chemical binding]; other site 326424009624 ATP binding site [chemical binding]; other site 326424009625 Phosphotransferase enzyme family; Region: APH; pfam01636 326424009626 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 326424009627 Cytochrome P450; Region: p450; cl12078 326424009628 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 326424009629 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 326424009630 NAD binding site [chemical binding]; other site 326424009631 catalytic residues [active] 326424009632 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 326424009633 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 326424009634 active site 326424009635 metal binding site [ion binding]; metal-binding site 326424009636 Evidence 7 : Gene remnant; Product type e : enzyme 326424009637 TIGR03086 family protein; Region: TIGR03086 326424009638 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 326424009639 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 326424009640 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 326424009641 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 326424009642 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 326424009643 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 326424009644 Protein of unknown function DUF72; Region: DUF72; pfam01904 326424009645 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424009646 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 326424009647 substrate binding site [chemical binding]; other site 326424009648 oxyanion hole (OAH) forming residues; other site 326424009649 trimer interface [polypeptide binding]; other site 326424009650 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326424009651 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424009652 salt bridge; other site 326424009653 non-specific DNA binding site [nucleotide binding]; other site 326424009654 sequence-specific DNA binding site [nucleotide binding]; other site 326424009655 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 326424009656 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 326424009657 N-terminal domain interface [polypeptide binding]; other site 326424009658 dimer interface [polypeptide binding]; other site 326424009659 substrate binding pocket (H-site) [chemical binding]; other site 326424009660 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 326424009661 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 326424009662 ligand binding site [chemical binding]; other site 326424009663 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 326424009664 iron-sulfur cluster [ion binding]; other site 326424009665 [2Fe-2S] cluster binding site [ion binding]; other site 326424009666 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 326424009667 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326424009668 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 326424009669 DNA binding residues [nucleotide binding] 326424009670 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424009671 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424009672 active site 326424009673 phosphorylation site [posttranslational modification] 326424009674 intermolecular recognition site; other site 326424009675 dimerization interface [polypeptide binding]; other site 326424009676 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 326424009677 dimerization interface [polypeptide binding]; other site 326424009678 DNA binding residues [nucleotide binding] 326424009679 2TM domain; Region: 2TM; pfam13239 326424009680 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 326424009681 Histidine kinase; Region: HisKA_3; pfam07730 326424009682 Predicted membrane protein [Function unknown]; Region: COG2311 326424009683 Protein of unknown function (DUF418); Region: DUF418; cl12135 326424009684 Protein of unknown function (DUF418); Region: DUF418; pfam04235 326424009685 Phosphotransferase enzyme family; Region: APH; pfam01636 326424009686 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 326424009687 active site 326424009688 ATP binding site [chemical binding]; other site 326424009689 Predicted membrane protein [Function unknown]; Region: COG4270 326424009690 TIR domain; Region: TIR_2; pfam13676 326424009691 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424009692 Tetratricopeptide repeat; Region: TPR_10; pfam13374 326424009693 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424009694 Tetratricopeptide repeat; Region: TPR_10; pfam13374 326424009695 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424009696 Tetratricopeptide repeat; Region: TPR_10; pfam13374 326424009697 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424009698 Tetratricopeptide repeat; Region: TPR_10; pfam13374 326424009699 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424009700 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424009701 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cl07841 326424009702 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 326424009703 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 326424009704 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 326424009705 D-pathway; other site 326424009706 Putative ubiquinol binding site [chemical binding]; other site 326424009707 Low-spin heme (heme b) binding site [chemical binding]; other site 326424009708 Putative water exit pathway; other site 326424009709 Binuclear center (heme o3/CuB) [ion binding]; other site 326424009710 K-pathway; other site 326424009711 Putative proton exit pathway; other site 326424009712 AAA ATPase domain; Region: AAA_16; pfam13191 326424009713 FOG: WD40 repeat [General function prediction only]; Region: COG2319 326424009714 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 326424009715 structural tetrad; other site 326424009716 FOG: WD40 repeat [General function prediction only]; Region: COG2319 326424009717 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 326424009718 structural tetrad; other site 326424009719 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 326424009720 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 326424009721 phosphopeptide binding site; other site 326424009722 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 326424009723 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 326424009724 phosphopeptide binding site; other site 326424009725 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 326424009726 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 326424009727 Walker A/P-loop; other site 326424009728 ATP binding site [chemical binding]; other site 326424009729 Q-loop/lid; other site 326424009730 ABC transporter signature motif; other site 326424009731 Walker B; other site 326424009732 D-loop; other site 326424009733 H-loop/switch region; other site 326424009734 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 326424009735 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 326424009736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 326424009737 MOSC domain; Region: MOSC; pfam03473 326424009738 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 326424009739 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 326424009740 acyl-activating enzyme (AAE) consensus motif; other site 326424009741 AMP binding site [chemical binding]; other site 326424009742 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 326424009743 MbtH-like protein; Region: MbtH; pfam03621 326424009744 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 326424009745 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424009746 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424009747 acyl-activating enzyme (AAE) consensus motif; other site 326424009748 AMP binding site [chemical binding]; other site 326424009749 active site 326424009750 CoA binding site [chemical binding]; other site 326424009751 salicylate synthase; Region: salicyl_syn; TIGR03494 326424009752 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 326424009753 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 326424009754 Condensation domain; Region: Condensation; pfam00668 326424009755 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326424009756 Nonribosomal peptide synthase; Region: NRPS; pfam08415 326424009757 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424009758 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 326424009759 acyl-activating enzyme (AAE) consensus motif; other site 326424009760 AMP binding site [chemical binding]; other site 326424009761 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326424009762 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 326424009763 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 326424009764 ABC-ATPase subunit interface; other site 326424009765 dimer interface [polypeptide binding]; other site 326424009766 putative PBP binding regions; other site 326424009767 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 326424009768 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 326424009769 ABC-ATPase subunit interface; other site 326424009770 dimer interface [polypeptide binding]; other site 326424009771 putative PBP binding regions; other site 326424009772 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 326424009773 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326424009774 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424009775 Walker A/P-loop; other site 326424009776 ATP binding site [chemical binding]; other site 326424009777 Q-loop/lid; other site 326424009778 ABC transporter signature motif; other site 326424009779 Walker B; other site 326424009780 D-loop; other site 326424009781 H-loop/switch region; other site 326424009782 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 326424009783 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424009784 Walker A/P-loop; other site 326424009785 ATP binding site [chemical binding]; other site 326424009786 Q-loop/lid; other site 326424009787 ABC transporter signature motif; other site 326424009788 Walker B; other site 326424009789 D-loop; other site 326424009790 H-loop/switch region; other site 326424009791 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 326424009792 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 326424009793 AMP binding site [chemical binding]; other site 326424009794 acyl-activating enzyme (AAE) consensus motif; other site 326424009795 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326424009796 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 326424009797 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 326424009798 intersubunit interface [polypeptide binding]; other site 326424009799 Condensation domain; Region: Condensation; pfam00668 326424009800 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326424009801 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 326424009802 acyl-activating enzyme (AAE) consensus motif; other site 326424009803 AMP binding site [chemical binding]; other site 326424009804 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424009805 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326424009806 Condensation domain; Region: Condensation; pfam00668 326424009807 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 326424009808 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 326424009809 AMP binding site [chemical binding]; other site 326424009810 acyl-activating enzyme (AAE) consensus motif; other site 326424009811 Condensation domain; Region: Condensation; pfam00668 326424009812 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326424009813 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 326424009814 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 326424009815 AMP binding site [chemical binding]; other site 326424009816 acyl-activating enzyme (AAE) consensus motif; other site 326424009817 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326424009818 Condensation domain; Region: Condensation; pfam00668 326424009819 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326424009820 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 326424009821 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 326424009822 acyl-activating enzyme (AAE) consensus motif; other site 326424009823 AMP binding site [chemical binding]; other site 326424009824 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326424009825 Condensation domain; Region: Condensation; pfam00668 326424009826 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 326424009827 Condensation domain; Region: Condensation; pfam00668 326424009828 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326424009829 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 326424009830 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 326424009831 acyl-activating enzyme (AAE) consensus motif; other site 326424009832 AMP binding site [chemical binding]; other site 326424009833 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326424009834 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 326424009835 RibD C-terminal domain; Region: RibD_C; pfam01872 326424009836 choline-sulfatase; Region: chol_sulfatase; TIGR03417 326424009837 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 326424009838 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 326424009839 NodB motif; other site 326424009840 active site 326424009841 catalytic site [active] 326424009842 metal binding site [ion binding]; metal-binding site 326424009843 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 326424009844 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 326424009845 active site 326424009846 NodB motif; other site 326424009847 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 326424009848 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 326424009849 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326424009850 active site 326424009851 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 326424009852 putative active site [active] 326424009853 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 326424009854 Protein of unknown function N-terminus (DUF3323); Region: DUF3323; pfam11796 326424009855 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 326424009856 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 326424009857 AAA domain; Region: AAA_30; pfam13604 326424009858 Family description; Region: UvrD_C_2; pfam13538 326424009859 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 326424009860 Tetratricopeptide repeat; Region: TPR_16; pfam13432 326424009861 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 326424009862 binding surface 326424009863 TPR motif; other site 326424009864 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424009865 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424009866 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 326424009867 TPR motif; other site 326424009868 binding surface 326424009869 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424009870 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424009871 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 326424009872 binding surface 326424009873 TPR motif; other site 326424009874 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424009875 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 326424009876 TPR motif; other site 326424009877 binding surface 326424009878 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424009879 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424009880 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424009881 CHAT domain; Region: CHAT; pfam12770 326424009882 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 326424009883 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 326424009884 Response regulator receiver domain; Region: Response_reg; pfam00072 326424009885 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424009886 active site 326424009887 phosphorylation site [posttranslational modification] 326424009888 intermolecular recognition site; other site 326424009889 dimerization interface [polypeptide binding]; other site 326424009890 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 326424009891 dimerization interface [polypeptide binding]; other site 326424009892 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326424009893 dimer interface [polypeptide binding]; other site 326424009894 phosphorylation site [posttranslational modification] 326424009895 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424009896 ATP binding site [chemical binding]; other site 326424009897 Mg2+ binding site [ion binding]; other site 326424009898 G-X-G motif; other site 326424009899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424009900 active site 326424009901 phosphorylation site [posttranslational modification] 326424009902 intermolecular recognition site; other site 326424009903 dimerization interface [polypeptide binding]; other site 326424009904 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 326424009905 putative binding surface; other site 326424009906 active site 326424009907 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 326424009908 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 326424009909 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 326424009910 NAD binding site [chemical binding]; other site 326424009911 catalytic residues [active] 326424009912 MarR family; Region: MarR_2; cl17246 326424009913 Transcriptional regulators [Transcription]; Region: MarR; COG1846 326424009914 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326424009915 dimerization interface [polypeptide binding]; other site 326424009916 putative DNA binding site [nucleotide binding]; other site 326424009917 putative Zn2+ binding site [ion binding]; other site 326424009918 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 326424009919 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424009920 putative substrate translocation pore; other site 326424009921 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 326424009922 Cytochrome P450; Region: p450; cl12078 326424009923 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 326424009924 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326424009925 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 326424009926 YCII-related domain; Region: YCII; cl00999 326424009927 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 326424009928 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 326424009929 putative active site [active] 326424009930 putative FMN binding site [chemical binding]; other site 326424009931 putative substrate binding site [chemical binding]; other site 326424009932 putative catalytic residue [active] 326424009933 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 326424009934 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 326424009935 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 326424009936 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 326424009937 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 326424009938 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 326424009939 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 326424009940 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 326424009941 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 326424009942 homodimer interface [polypeptide binding]; other site 326424009943 NADP binding site [chemical binding]; other site 326424009944 substrate binding site [chemical binding]; other site 326424009945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424009946 S-adenosylmethionine binding site [chemical binding]; other site 326424009947 topology modulation protein; Reviewed; Region: PRK08118 326424009948 AAA domain; Region: AAA_17; pfam13207 326424009949 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 326424009950 Scramblase; Region: Scramblase; pfam03803 326424009951 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 326424009952 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424009953 Walker A/P-loop; other site 326424009954 ATP binding site [chemical binding]; other site 326424009955 Q-loop/lid; other site 326424009956 ABC transporter signature motif; other site 326424009957 Walker B; other site 326424009958 D-loop; other site 326424009959 H-loop/switch region; other site 326424009960 ABC transporter; Region: ABC_tran_2; pfam12848 326424009961 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326424009962 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326424009963 Radical SAM superfamily; Region: Radical_SAM; pfam04055 326424009964 FeS/SAM binding site; other site 326424009965 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 326424009966 Protein of unknown function (DUF402); Region: DUF402; pfam04167 326424009967 hypothetical protein; Provisional; Region: PRK06547 326424009968 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 326424009969 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 326424009970 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 326424009971 Putative esterase; Region: Esterase; pfam00756 326424009972 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 326424009973 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 326424009974 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 326424009975 P-loop; other site 326424009976 Magnesium ion binding site [ion binding]; other site 326424009977 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 326424009978 Magnesium ion binding site [ion binding]; other site 326424009979 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 326424009980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424009981 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 326424009982 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 326424009983 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 326424009984 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 326424009985 Ligand Binding Site [chemical binding]; other site 326424009986 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 326424009987 Ligand Binding Site [chemical binding]; other site 326424009988 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 326424009989 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 326424009990 DNA-binding site [nucleotide binding]; DNA binding site 326424009991 RNA-binding motif; other site 326424009992 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 326424009993 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 326424009994 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326424009995 catalytic residue [active] 326424009996 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 326424009997 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 326424009998 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 326424009999 FAD binding site [chemical binding]; other site 326424010000 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 326424010001 cytosine deaminase; Validated; Region: PRK07572 326424010002 active site 326424010003 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 326424010004 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 326424010005 Walker A/P-loop; other site 326424010006 ATP binding site [chemical binding]; other site 326424010007 Q-loop/lid; other site 326424010008 ABC transporter signature motif; other site 326424010009 Walker B; other site 326424010010 D-loop; other site 326424010011 H-loop/switch region; other site 326424010012 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 326424010013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424010014 dimer interface [polypeptide binding]; other site 326424010015 conserved gate region; other site 326424010016 putative PBP binding loops; other site 326424010017 ABC-ATPase subunit interface; other site 326424010018 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 326424010019 FAD binding domain; Region: FAD_binding_4; pfam01565 326424010020 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 326424010021 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 326424010022 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 326424010023 Creatinine amidohydrolase; Region: Creatininase; pfam02633 326424010024 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 326424010025 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424010026 Cupin domain; Region: Cupin_2; pfam07883 326424010027 Amidase; Region: Amidase; cl11426 326424010028 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 326424010029 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 326424010030 Cupin domain; Region: Cupin_2; cl17218 326424010031 Isochorismatase family; Region: Isochorismatase; pfam00857 326424010032 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 326424010033 catalytic triad [active] 326424010034 conserved cis-peptide bond; other site 326424010035 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 326424010036 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326424010037 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424010038 sequence-specific DNA binding site [nucleotide binding]; other site 326424010039 salt bridge; other site 326424010040 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 326424010041 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 326424010042 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424010043 NADH(P)-binding; Region: NAD_binding_10; pfam13460 326424010044 NAD(P) binding site [chemical binding]; other site 326424010045 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 326424010046 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 326424010047 oligomer interface [polypeptide binding]; other site 326424010048 active site residues [active] 326424010049 Clp protease; Region: CLP_protease; pfam00574 326424010050 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 326424010051 oligomer interface [polypeptide binding]; other site 326424010052 active site residues [active] 326424010053 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 326424010054 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 326424010055 DNA binding residues [nucleotide binding] 326424010056 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 326424010057 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 326424010058 DNA binding residues [nucleotide binding] 326424010059 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326424010060 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 326424010061 dimer interface [polypeptide binding]; other site 326424010062 substrate binding site [chemical binding]; other site 326424010063 metal binding site [ion binding]; metal-binding site 326424010064 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424010065 NAD(P) binding site [chemical binding]; other site 326424010066 active site 326424010067 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 326424010068 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 326424010069 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 326424010070 NAD(P) binding site [chemical binding]; other site 326424010071 catalytic residues [active] 326424010072 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 326424010073 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 326424010074 TPP-binding site [chemical binding]; other site 326424010075 tetramer interface [polypeptide binding]; other site 326424010076 heterodimer interface [polypeptide binding]; other site 326424010077 phosphorylation loop region [posttranslational modification] 326424010078 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 326424010079 hypothetical protein; Reviewed; Region: PRK09588 326424010080 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 326424010081 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 326424010082 Multicopper oxidase; Region: Cu-oxidase; pfam00394 326424010083 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 326424010084 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 326424010085 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 326424010086 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 326424010087 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 326424010088 active site 326424010089 DNA binding site [nucleotide binding] 326424010090 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 326424010091 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 326424010092 AlkA N-terminal domain; Region: AlkA_N; pfam06029 326424010093 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 326424010094 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 326424010095 minor groove reading motif; other site 326424010096 helix-hairpin-helix signature motif; other site 326424010097 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 326424010098 NAD+ binding site [chemical binding]; other site 326424010099 substrate binding site [chemical binding]; other site 326424010100 Zn binding site [ion binding]; other site 326424010101 HupF/HypC family; Region: HupF_HypC; cl00394 326424010102 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 326424010103 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 326424010104 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326424010105 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 326424010106 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 326424010107 active site 326424010108 substrate binding site [chemical binding]; other site 326424010109 ATP binding site [chemical binding]; other site 326424010110 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 326424010111 nudix motif; other site 326424010112 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 326424010113 Frankia-40 domain; Region: Frankia_40_dom; TIGR03917 326424010114 CopC domain; Region: CopC; pfam04234 326424010115 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 326424010116 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 326424010117 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 326424010118 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 326424010119 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 326424010120 Soluble P-type ATPase [General function prediction only]; Region: COG4087 326424010121 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 326424010122 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 326424010123 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 326424010124 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 326424010125 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326424010126 motif II; other site 326424010127 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 326424010128 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 326424010129 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424010130 mycofactocin system FadH/OYE family oxidoreductase 1; Region: mycofact_OYE_1; TIGR03996 326424010131 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 326424010132 phosphate binding site [ion binding]; other site 326424010133 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 326424010134 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 326424010135 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 326424010136 phosphate binding site [ion binding]; other site 326424010137 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326424010138 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 326424010139 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 326424010140 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326424010141 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326424010142 homodimer interface [polypeptide binding]; other site 326424010143 catalytic residue [active] 326424010144 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 326424010145 Amidinotransferase; Region: Amidinotransf; pfam02274 326424010146 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424010147 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424010148 active site 326424010149 ATP binding site [chemical binding]; other site 326424010150 substrate binding site [chemical binding]; other site 326424010151 activation loop (A-loop); other site 326424010152 FOG: WD40 repeat [General function prediction only]; Region: COG2319 326424010153 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 326424010154 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 326424010155 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 326424010156 FAD binding pocket [chemical binding]; other site 326424010157 FAD binding motif [chemical binding]; other site 326424010158 phosphate binding motif [ion binding]; other site 326424010159 NAD binding pocket [chemical binding]; other site 326424010160 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 326424010161 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424010162 Walker A/P-loop; other site 326424010163 ATP binding site [chemical binding]; other site 326424010164 Q-loop/lid; other site 326424010165 ABC transporter signature motif; other site 326424010166 Walker B; other site 326424010167 D-loop; other site 326424010168 H-loop/switch region; other site 326424010169 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424010170 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424010171 active site 326424010172 ATP binding site [chemical binding]; other site 326424010173 substrate binding site [chemical binding]; other site 326424010174 activation loop (A-loop); other site 326424010175 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 326424010176 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 326424010177 substrate binding pocket [chemical binding]; other site 326424010178 membrane-bound complex binding site; other site 326424010179 hinge residues; other site 326424010180 HD domain; Region: HD_3; pfam13023 326424010181 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 326424010182 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 326424010183 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 326424010184 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 326424010185 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 326424010186 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 326424010187 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 326424010188 heme binding site [chemical binding]; other site 326424010189 ferroxidase pore; other site 326424010190 ferroxidase diiron center [ion binding]; other site 326424010191 Response regulator receiver domain; Region: Response_reg; pfam00072 326424010192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424010193 active site 326424010194 phosphorylation site [posttranslational modification] 326424010195 intermolecular recognition site; other site 326424010196 dimerization interface [polypeptide binding]; other site 326424010197 CoA-transferase family III; Region: CoA_transf_3; pfam02515 326424010198 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 326424010199 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 326424010200 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 326424010201 NAD(P) binding site [chemical binding]; other site 326424010202 catalytic residues [active] 326424010203 Proline dehydrogenase; Region: Pro_dh; cl03282 326424010204 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424010205 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424010206 active site 326424010207 ATP binding site [chemical binding]; other site 326424010208 substrate binding site [chemical binding]; other site 326424010209 activation loop (A-loop); other site 326424010210 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 326424010211 Interdomain contacts; other site 326424010212 Cytokine receptor motif; other site 326424010213 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 326424010214 Interdomain contacts; other site 326424010215 Cytokine receptor motif; other site 326424010216 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 326424010217 Interdomain contacts; other site 326424010218 Cytokine receptor motif; other site 326424010219 Protein of unknown function (DUF742); Region: DUF742; pfam05331 326424010220 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 326424010221 Nitrate and nitrite sensing; Region: NIT; pfam08376 326424010222 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326424010223 HAMP domain; Region: HAMP; pfam00672 326424010224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424010225 ATP binding site [chemical binding]; other site 326424010226 Mg2+ binding site [ion binding]; other site 326424010227 G-X-G motif; other site 326424010228 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 326424010229 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 326424010230 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 326424010231 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 326424010232 Walker A/P-loop; other site 326424010233 ATP binding site [chemical binding]; other site 326424010234 Q-loop/lid; other site 326424010235 ABC transporter signature motif; other site 326424010236 Walker B; other site 326424010237 D-loop; other site 326424010238 H-loop/switch region; other site 326424010239 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 326424010240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424010241 dimer interface [polypeptide binding]; other site 326424010242 conserved gate region; other site 326424010243 ABC-ATPase subunit interface; other site 326424010244 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 326424010245 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 326424010246 active site 326424010247 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424010248 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326424010249 DNA binding residues [nucleotide binding] 326424010250 dimerization interface [polypeptide binding]; other site 326424010251 Necrosis inducing protein (NPP1); Region: NPP1; pfam05630 326424010252 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 326424010253 putative active site [active] 326424010254 putative metal binding site [ion binding]; other site 326424010255 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 326424010256 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 326424010257 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 326424010258 homodimer interface [polypeptide binding]; other site 326424010259 substrate-cofactor binding pocket; other site 326424010260 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326424010261 catalytic residue [active] 326424010262 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 326424010263 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 326424010264 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 326424010265 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 326424010266 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 326424010267 putative active site [active] 326424010268 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 326424010269 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424010270 Walker A/P-loop; other site 326424010271 ATP binding site [chemical binding]; other site 326424010272 Q-loop/lid; other site 326424010273 ABC transporter signature motif; other site 326424010274 Walker B; other site 326424010275 D-loop; other site 326424010276 H-loop/switch region; other site 326424010277 TOBE domain; Region: TOBE_2; pfam08402 326424010278 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 326424010279 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 326424010280 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 326424010281 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 326424010282 active site 326424010283 metal binding site [ion binding]; metal-binding site 326424010284 hexamer interface [polypeptide binding]; other site 326424010285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424010286 dimer interface [polypeptide binding]; other site 326424010287 conserved gate region; other site 326424010288 ABC-ATPase subunit interface; other site 326424010289 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 326424010290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424010291 dimer interface [polypeptide binding]; other site 326424010292 conserved gate region; other site 326424010293 putative PBP binding loops; other site 326424010294 ABC-ATPase subunit interface; other site 326424010295 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 326424010296 Zeta toxin; Region: Zeta_toxin; pfam06414 326424010297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 326424010298 SnoaL-like domain; Region: SnoaL_2; pfam12680 326424010299 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 326424010300 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 326424010301 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830 326424010302 active site 326424010303 ADP/pyrophosphate binding site [chemical binding]; other site 326424010304 dimerization interface [polypeptide binding]; other site 326424010305 allosteric effector site; other site 326424010306 fructose-1,6-bisphosphate binding site; other site 326424010307 FOG: WD40 repeat [General function prediction only]; Region: COG2319 326424010308 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 326424010309 Part of AAA domain; Region: AAA_19; pfam13245 326424010310 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 326424010311 AAA domain; Region: AAA_12; pfam13087 326424010312 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 326424010313 putative active site [active] 326424010314 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 326424010315 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424010316 substrate binding site [chemical binding]; other site 326424010317 oxyanion hole (OAH) forming residues; other site 326424010318 trimer interface [polypeptide binding]; other site 326424010319 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 326424010320 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 326424010321 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 326424010322 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 326424010323 active site 326424010324 DNA binding site [nucleotide binding] 326424010325 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 326424010326 DNA binding site [nucleotide binding] 326424010327 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 326424010328 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 326424010329 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424010330 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 326424010331 NAD(P) binding site [chemical binding]; other site 326424010332 active site 326424010333 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 326424010334 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 326424010335 active site 326424010336 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 326424010337 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 326424010338 dimer interface [polypeptide binding]; other site 326424010339 active site 326424010340 Cupin domain; Region: Cupin_2; pfam07883 326424010341 N-terminal aromatase/cyclase domain of the multifunctional protein tetracenomycin (TcmN) and related domains; Region: TcmN_ARO-CYC_like; cd08860 326424010342 putative hydrophobic ligand binding site [chemical binding]; other site 326424010343 active site 326424010344 catalytic residues_2 [active] 326424010345 catalytic residues_1 [active] 326424010346 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 326424010347 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673 326424010348 Predicted transcriptional regulators [Transcription]; Region: COG1378 326424010349 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 326424010350 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 326424010351 DNA binding residues [nucleotide binding] 326424010352 dimerization interface [polypeptide binding]; other site 326424010353 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424010354 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 326424010355 Switch I region; other site 326424010356 G3 box; other site 326424010357 Switch II region; other site 326424010358 GTP/Mg2+ binding site [chemical binding]; other site 326424010359 G4 box; other site 326424010360 G5 box; other site 326424010361 Protein of unknown function (DUF742); Region: DUF742; pfam05331 326424010362 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 326424010363 Nitrate and nitrite sensing; Region: NIT; pfam08376 326424010364 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326424010365 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424010366 ATP binding site [chemical binding]; other site 326424010367 Mg2+ binding site [ion binding]; other site 326424010368 G-X-G motif; other site 326424010369 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 326424010370 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 326424010371 active site 2 [active] 326424010372 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424010373 substrate binding site [chemical binding]; other site 326424010374 oxyanion hole (OAH) forming residues; other site 326424010375 trimer interface [polypeptide binding]; other site 326424010376 Protein of unknown function (DUF445); Region: DUF445; pfam04286 326424010377 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 326424010378 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 326424010379 ATP binding site [chemical binding]; other site 326424010380 putative Mg++ binding site [ion binding]; other site 326424010381 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326424010382 nucleotide binding region [chemical binding]; other site 326424010383 ATP-binding site [chemical binding]; other site 326424010384 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 326424010385 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 326424010386 catalytic site [active] 326424010387 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 326424010388 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326424010389 catalytic residue [active] 326424010390 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 326424010391 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 326424010392 active site 326424010393 PHP Thumb interface [polypeptide binding]; other site 326424010394 metal binding site [ion binding]; metal-binding site 326424010395 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 326424010396 generic binding surface II; other site 326424010397 generic binding surface I; other site 326424010398 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 326424010399 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424010400 S-adenosylmethionine binding site [chemical binding]; other site 326424010401 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 326424010402 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326424010403 catalytic residue [active] 326424010404 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 326424010405 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 326424010406 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 326424010407 NAD(P) binding site [chemical binding]; other site 326424010408 catalytic residues [active] 326424010409 L-lysine aminotransferase; Provisional; Region: PRK08297 326424010410 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 326424010411 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326424010412 catalytic residue [active] 326424010413 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424010414 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424010415 active site 326424010416 ATP binding site [chemical binding]; other site 326424010417 substrate binding site [chemical binding]; other site 326424010418 activation loop (A-loop); other site 326424010419 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 326424010420 Protein kinase domain; Region: Pkinase; pfam00069 326424010421 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424010422 active site 326424010423 ATP binding site [chemical binding]; other site 326424010424 substrate binding site [chemical binding]; other site 326424010425 activation loop (A-loop); other site 326424010426 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424010427 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424010428 active site 326424010429 ATP binding site [chemical binding]; other site 326424010430 substrate binding site [chemical binding]; other site 326424010431 activation loop (A-loop); other site 326424010432 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 326424010433 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 326424010434 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 326424010435 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 326424010436 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424010437 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424010438 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 326424010439 putative FMN binding site [chemical binding]; other site 326424010440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424010441 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326424010442 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 326424010443 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326424010444 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 326424010445 dimerization interface [polypeptide binding]; other site 326424010446 substrate binding pocket [chemical binding]; other site 326424010447 short chain dehydrogenase; Provisional; Region: PRK06180 326424010448 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424010449 NAD(P) binding site [chemical binding]; other site 326424010450 active site 326424010451 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 326424010452 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 326424010453 Probable transposase; Region: OrfB_IS605; pfam01385 326424010454 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 326424010455 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 326424010456 Clp protease ATP binding subunit; Region: clpC; CHL00095 326424010457 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 326424010458 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424010459 OsmC-like protein; Region: OsmC; pfam02566 326424010460 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 326424010461 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 326424010462 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326424010463 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326424010464 active site 326424010465 catalytic tetrad [active] 326424010466 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 326424010467 short chain dehydrogenase; Provisional; Region: PRK07454 326424010468 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 326424010469 NADP binding site [chemical binding]; other site 326424010470 substrate binding site [chemical binding]; other site 326424010471 active site 326424010472 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 326424010473 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326424010474 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 326424010475 dimerization interface [polypeptide binding]; other site 326424010476 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 326424010477 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 326424010478 catalytic triad [active] 326424010479 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424010480 S-adenosylmethionine binding site [chemical binding]; other site 326424010481 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 326424010482 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 326424010483 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 326424010484 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 326424010485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 326424010486 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 326424010487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424010488 dimer interface [polypeptide binding]; other site 326424010489 ABC-ATPase subunit interface; other site 326424010490 putative PBP binding loops; other site 326424010491 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 326424010492 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326424010493 Walker A/P-loop; other site 326424010494 ATP binding site [chemical binding]; other site 326424010495 Q-loop/lid; other site 326424010496 ABC transporter signature motif; other site 326424010497 Walker B; other site 326424010498 D-loop; other site 326424010499 H-loop/switch region; other site 326424010500 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 326424010501 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326424010502 Walker A/P-loop; other site 326424010503 ATP binding site [chemical binding]; other site 326424010504 Q-loop/lid; other site 326424010505 ABC transporter signature motif; other site 326424010506 Walker B; other site 326424010507 D-loop; other site 326424010508 H-loop/switch region; other site 326424010509 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 326424010510 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 326424010511 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 326424010512 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424010513 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 326424010514 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 326424010515 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 326424010516 active site 326424010517 non-prolyl cis peptide bond; other site 326424010518 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424010519 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326424010520 Coenzyme A binding pocket [chemical binding]; other site 326424010521 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 326424010522 Protein of unknown function DUF86; Region: DUF86; cl01031 326424010523 Integrase core domain; Region: rve; pfam00665 326424010524 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 326424010525 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 326424010526 Bacterial transcriptional activator domain; Region: BTAD; smart01043 326424010527 Predicted ATPase [General function prediction only]; Region: COG3903 326424010528 ABC-2 type transporter; Region: ABC2_membrane; cl17235 326424010529 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 326424010530 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 326424010531 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424010532 Walker A/P-loop; other site 326424010533 ATP binding site [chemical binding]; other site 326424010534 Q-loop/lid; other site 326424010535 ABC transporter signature motif; other site 326424010536 Walker B; other site 326424010537 D-loop; other site 326424010538 H-loop/switch region; other site 326424010539 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 326424010540 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 326424010541 conserved cys residue [active] 326424010542 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 326424010543 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 326424010544 Isochorismatase family; Region: Isochorismatase; pfam00857 326424010545 catalytic triad [active] 326424010546 conserved cis-peptide bond; other site 326424010547 SnoaL-like domain; Region: SnoaL_4; pfam13577 326424010548 Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561 326424010549 substrate binding site [chemical binding]; other site 326424010550 Ferritin-like; Region: Ferritin-like; pfam12902 326424010551 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 326424010552 Putative cyclase; Region: Cyclase; cl00814 326424010553 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 326424010554 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 326424010555 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 326424010556 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 326424010557 putative metal binding site [ion binding]; other site 326424010558 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 326424010559 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326424010560 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326424010561 active site 326424010562 catalytic tetrad [active] 326424010563 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 326424010564 Domain of unknown function (DUF222); Region: DUF222; pfam02720 326424010565 SpoOM protein; Region: Spo0M; pfam07070 326424010566 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 326424010567 Methyltransferase domain; Region: Methyltransf_23; pfam13489 326424010568 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424010569 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 326424010570 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 326424010571 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 326424010572 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 326424010573 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 326424010574 dimer interface [polypeptide binding]; other site 326424010575 active site 326424010576 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 326424010577 Ligand Binding Site [chemical binding]; other site 326424010578 Molecular Tunnel; other site 326424010579 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 326424010580 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 326424010581 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 326424010582 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326424010583 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 326424010584 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 326424010585 dimerization interface [polypeptide binding]; other site 326424010586 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 326424010587 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 326424010588 dimer interface [polypeptide binding]; other site 326424010589 decamer (pentamer of dimers) interface [polypeptide binding]; other site 326424010590 catalytic triad [active] 326424010591 peroxidatic and resolving cysteines [active] 326424010592 C-terminal domain of 1-Cys peroxiredoxin; Region: 1-cysPrx_C; pfam10417 326424010593 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 326424010594 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 326424010595 Transcriptional regulators [Transcription]; Region: FadR; COG2186 326424010596 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326424010597 DNA-binding site [nucleotide binding]; DNA binding site 326424010598 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 326424010599 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 326424010600 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 326424010601 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 326424010602 dinuclear metal binding motif [ion binding]; other site 326424010603 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 326424010604 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 326424010605 ligand binding site [chemical binding]; other site 326424010606 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 326424010607 active site 326424010608 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 326424010609 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 326424010610 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 326424010611 urate oxidase; Region: urate_oxi; TIGR03383 326424010612 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 326424010613 active site 326424010614 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 326424010615 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 326424010616 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 326424010617 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 326424010618 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326424010619 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 326424010620 active site 326424010621 catalytic triad [active] 326424010622 oxyanion hole [active] 326424010623 conserved hypothetical protein; Region: TIGR03847 326424010624 ferrochelatase; Reviewed; Region: hemH; PRK00035 326424010625 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 326424010626 C-terminal domain interface [polypeptide binding]; other site 326424010627 active site 326424010628 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 326424010629 active site 326424010630 N-terminal domain interface [polypeptide binding]; other site 326424010631 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 326424010632 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424010633 NAD(P) binding site [chemical binding]; other site 326424010634 active site 326424010635 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 326424010636 TPP-binding site [chemical binding]; other site 326424010637 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 326424010638 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424010639 NAD(P) binding site [chemical binding]; other site 326424010640 active site 326424010641 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 326424010642 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 326424010643 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 326424010644 TrkA-C domain; Region: TrkA_C; pfam02080 326424010645 Putative transmembrane protein (PGPGW); Region: PGPGW; pfam09656 326424010646 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 326424010647 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 326424010648 Predicted dehydrogenase [General function prediction only]; Region: COG0579 326424010649 hydroxyglutarate oxidase; Provisional; Region: PRK11728 326424010650 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 326424010651 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 326424010652 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326424010653 catalytic residue [active] 326424010654 Domain of unknown function (DUF222); Region: DUF222; pfam02720 326424010655 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 326424010656 active site 326424010657 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424010658 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 326424010659 dimerization interface [polypeptide binding]; other site 326424010660 DNA binding residues [nucleotide binding] 326424010661 pyruvate kinase; Provisional; Region: PRK06247 326424010662 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 326424010663 domain interfaces; other site 326424010664 active site 326424010665 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 326424010666 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326424010667 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424010668 Walker A/P-loop; other site 326424010669 ATP binding site [chemical binding]; other site 326424010670 Q-loop/lid; other site 326424010671 ABC transporter signature motif; other site 326424010672 Walker B; other site 326424010673 D-loop; other site 326424010674 H-loop/switch region; other site 326424010675 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 326424010676 Cation efflux family; Region: Cation_efflux; pfam01545 326424010677 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 326424010678 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424010679 Walker A/P-loop; other site 326424010680 ATP binding site [chemical binding]; other site 326424010681 Q-loop/lid; other site 326424010682 ABC transporter signature motif; other site 326424010683 Walker B; other site 326424010684 D-loop; other site 326424010685 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326424010686 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 326424010687 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 326424010688 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 326424010689 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 326424010690 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 326424010691 Uncharacterized conserved protein [Function unknown]; Region: COG2308 326424010692 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 326424010693 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 326424010694 NAD binding site [chemical binding]; other site 326424010695 substrate binding site [chemical binding]; other site 326424010696 homodimer interface [polypeptide binding]; other site 326424010697 active site 326424010698 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 326424010699 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 326424010700 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 326424010701 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 326424010702 oligomer interface; other site 326424010703 ligand binding site; other site 326424010704 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 326424010705 dimer interface [polypeptide binding]; other site 326424010706 N-terminal domain interface [polypeptide binding]; other site 326424010707 sulfate 1 binding site; other site 326424010708 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 326424010709 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 326424010710 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 326424010711 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 326424010712 trimerization site [polypeptide binding]; other site 326424010713 active site 326424010714 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 326424010715 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 326424010716 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326424010717 catalytic residue [active] 326424010718 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 326424010719 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 326424010720 Walker A/P-loop; other site 326424010721 ATP binding site [chemical binding]; other site 326424010722 Q-loop/lid; other site 326424010723 ABC transporter signature motif; other site 326424010724 Walker B; other site 326424010725 D-loop; other site 326424010726 H-loop/switch region; other site 326424010727 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 326424010728 [2Fe-2S] cluster binding site [ion binding]; other site 326424010729 FeS assembly protein SufD; Region: sufD; TIGR01981 326424010730 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 326424010731 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 326424010732 FeS assembly protein SufB; Region: sufB; TIGR01980 326424010733 Predicted transcriptional regulator [Transcription]; Region: COG2345 326424010734 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326424010735 putative DNA binding site [nucleotide binding]; other site 326424010736 putative Zn2+ binding site [ion binding]; other site 326424010737 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 326424010738 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 326424010739 N- and C-terminal domain interface [polypeptide binding]; other site 326424010740 active site 326424010741 MgATP binding site [chemical binding]; other site 326424010742 catalytic site [active] 326424010743 metal binding site [ion binding]; metal-binding site 326424010744 glycerol binding site [chemical binding]; other site 326424010745 homotetramer interface [polypeptide binding]; other site 326424010746 homodimer interface [polypeptide binding]; other site 326424010747 FBP binding site [chemical binding]; other site 326424010748 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424010749 sequence-specific DNA binding site [nucleotide binding]; other site 326424010750 salt bridge; other site 326424010751 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 326424010752 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 326424010753 Walker A/P-loop; other site 326424010754 ATP binding site [chemical binding]; other site 326424010755 Q-loop/lid; other site 326424010756 ABC transporter signature motif; other site 326424010757 Walker B; other site 326424010758 D-loop; other site 326424010759 H-loop/switch region; other site 326424010760 ABC-2 type transporter; Region: ABC2_membrane; cl17235 326424010761 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 326424010762 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 326424010763 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 326424010764 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 326424010765 UbiA prenyltransferase family; Region: UbiA; pfam01040 326424010766 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 326424010767 putative active site [active] 326424010768 transaldolase; Provisional; Region: PRK03903 326424010769 catalytic residue [active] 326424010770 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 326424010771 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 326424010772 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 326424010773 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 326424010774 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 326424010775 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 326424010776 putative active site [active] 326424010777 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 326424010778 Short C-terminal domain; Region: SHOCT; pfam09851 326424010779 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424010780 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424010781 active site 326424010782 ATP binding site [chemical binding]; other site 326424010783 substrate binding site [chemical binding]; other site 326424010784 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 326424010785 substrate binding site [chemical binding]; other site 326424010786 activation loop (A-loop); other site 326424010787 activation loop (A-loop); other site 326424010788 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 326424010789 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 326424010790 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 326424010791 triosephosphate isomerase; Provisional; Region: PRK14567 326424010792 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 326424010793 substrate binding site [chemical binding]; other site 326424010794 dimer interface [polypeptide binding]; other site 326424010795 catalytic triad [active] 326424010796 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 326424010797 Phosphoglycerate kinase; Region: PGK; pfam00162 326424010798 substrate binding site [chemical binding]; other site 326424010799 hinge regions; other site 326424010800 ADP binding site [chemical binding]; other site 326424010801 catalytic site [active] 326424010802 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 326424010803 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 326424010804 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 326424010805 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 326424010806 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 326424010807 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 326424010808 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 326424010809 phosphate binding site [ion binding]; other site 326424010810 putative substrate binding pocket [chemical binding]; other site 326424010811 dimer interface [polypeptide binding]; other site 326424010812 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 326424010813 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 326424010814 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 326424010815 GIY-YIG motif/motif A; other site 326424010816 active site 326424010817 catalytic site [active] 326424010818 putative DNA binding site [nucleotide binding]; other site 326424010819 metal binding site [ion binding]; metal-binding site 326424010820 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 326424010821 Helix-hairpin-helix motif; Region: HHH; pfam00633 326424010822 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 326424010823 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 326424010824 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 326424010825 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 326424010826 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 326424010827 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 326424010828 RibD C-terminal domain; Region: RibD_C; cl17279 326424010829 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424010830 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424010831 active site 326424010832 ATP binding site [chemical binding]; other site 326424010833 substrate binding site [chemical binding]; other site 326424010834 activation loop (A-loop); other site 326424010835 FOG: WD40 repeat [General function prediction only]; Region: COG2319 326424010836 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 326424010837 structural tetrad; other site 326424010838 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 326424010839 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 326424010840 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 326424010841 active site 326424010842 HTH domain; Region: HTH_11; pfam08279 326424010843 WYL domain; Region: WYL; pfam13280 326424010844 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 326424010845 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 326424010846 excinuclease ABC subunit B; Provisional; Region: PRK05298 326424010847 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326424010848 putative Mg++ binding site [ion binding]; other site 326424010849 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326424010850 nucleotide binding region [chemical binding]; other site 326424010851 ATP-binding site [chemical binding]; other site 326424010852 Ultra-violet resistance protein B; Region: UvrB; pfam12344 326424010853 UvrB/uvrC motif; Region: UVR; pfam02151 326424010854 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 326424010855 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 326424010856 CoA-binding site [chemical binding]; other site 326424010857 ATP-binding [chemical binding]; other site 326424010858 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 326424010859 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 326424010860 active site 326424010861 Zn binding site [ion binding]; other site 326424010862 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 326424010863 metal binding site [ion binding]; metal-binding site 326424010864 active site 326424010865 I-site; other site 326424010866 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 326424010867 DNA polymerase I; Provisional; Region: PRK05755 326424010868 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 326424010869 active site 326424010870 metal binding site 1 [ion binding]; metal-binding site 326424010871 putative 5' ssDNA interaction site; other site 326424010872 metal binding site 3; metal-binding site 326424010873 metal binding site 2 [ion binding]; metal-binding site 326424010874 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 326424010875 putative DNA binding site [nucleotide binding]; other site 326424010876 putative metal binding site [ion binding]; other site 326424010877 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 326424010878 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 326424010879 active site 326424010880 DNA binding site [nucleotide binding] 326424010881 catalytic site [active] 326424010882 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 326424010883 CoenzymeA binding site [chemical binding]; other site 326424010884 subunit interaction site [polypeptide binding]; other site 326424010885 PHB binding site; other site 326424010886 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 326424010887 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 326424010888 dimerization interface [polypeptide binding]; other site 326424010889 ligand binding site [chemical binding]; other site 326424010890 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 326424010891 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 326424010892 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 326424010893 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424010894 active site 326424010895 phosphorylation site [posttranslational modification] 326424010896 intermolecular recognition site; other site 326424010897 dimerization interface [polypeptide binding]; other site 326424010898 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 326424010899 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 326424010900 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 326424010901 catalytic residues [active] 326424010902 catalytic nucleophile [active] 326424010903 Recombinase; Region: Recombinase; pfam07508 326424010904 Integrase core domain; Region: rve; pfam00665 326424010905 Integrase core domain; Region: rve_3; cl15866 326424010906 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 326424010907 active site 326424010908 catalytic residues [active] 326424010909 DNA binding site [nucleotide binding] 326424010910 Int/Topo IB signature motif; other site 326424010911 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 326424010912 short chain dehydrogenase; Provisional; Region: PRK06523 326424010913 classical (c) SDRs; Region: SDR_c; cd05233 326424010914 NAD(P) binding site [chemical binding]; other site 326424010915 active site 326424010916 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 326424010917 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 326424010918 FAD binding domain; Region: FAD_binding_4; pfam01565 326424010919 Berberine and berberine like; Region: BBE; pfam08031 326424010920 Cupin domain; Region: Cupin_2; pfam07883 326424010921 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326424010922 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 326424010923 active site 326424010924 metal binding site [ion binding]; metal-binding site 326424010925 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 326424010926 active site 326424010927 NAD binding site [chemical binding]; other site 326424010928 metal binding site [ion binding]; metal-binding site 326424010929 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 326424010930 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 326424010931 inhibitor-cofactor binding pocket; inhibition site 326424010932 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326424010933 catalytic residue [active] 326424010934 pyranose oxidase; Region: pyranose_ox; TIGR02462 326424010935 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 326424010936 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 326424010937 Cupin domain; Region: Cupin_2; cl17218 326424010938 Cupin domain; Region: Cupin_2; pfam07883 326424010939 Cupin domain; Region: Cupin_2; cl17218 326424010940 Cupin domain; Region: Cupin_2; cl17218 326424010941 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 326424010942 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 326424010943 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 326424010944 acyl-activating enzyme (AAE) consensus motif; other site 326424010945 active site 326424010946 AMP binding site [chemical binding]; other site 326424010947 substrate binding site [chemical binding]; other site 326424010948 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 326424010949 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 326424010950 dimer interface [polypeptide binding]; other site 326424010951 active site 326424010952 salicylate synthase MbtI; Reviewed; Region: PRK07912 326424010953 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 326424010954 Winged helix-turn helix; Region: HTH_29; pfam13551 326424010955 Winged helix-turn helix; Region: HTH_33; pfam13592 326424010956 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 326424010957 DDE superfamily endonuclease; Region: DDE_3; pfam13358 326424010958 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 326424010959 hypothetical protein; Provisional; Region: PRK07206 326424010960 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 326424010961 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 326424010962 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 326424010963 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 326424010964 metal binding site [ion binding]; metal-binding site 326424010965 putative dimer interface [polypeptide binding]; other site 326424010966 H+ Antiporter protein; Region: 2A0121; TIGR00900 326424010967 H+ Antiporter protein; Region: 2A0121; TIGR00900 326424010968 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 326424010969 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 326424010970 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 326424010971 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 326424010972 homodimer interface [polypeptide binding]; other site 326424010973 substrate-cofactor binding pocket; other site 326424010974 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326424010975 catalytic residue [active] 326424010976 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 326424010977 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 326424010978 active site 326424010979 metal binding site [ion binding]; metal-binding site 326424010980 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 326424010981 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424010982 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424010983 active site 326424010984 ATP binding site [chemical binding]; other site 326424010985 substrate binding site [chemical binding]; other site 326424010986 activation loop (A-loop); other site 326424010987 NHL repeat; Region: NHL; pfam01436 326424010988 NHL repeat; Region: NHL; pfam01436 326424010989 NHL repeat; Region: NHL; pfam01436 326424010990 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 326424010991 CoA-transferase family III; Region: CoA_transf_3; pfam02515 326424010992 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 326424010993 CoA-transferase family III; Region: CoA_transf_3; pfam02515 326424010994 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 326424010995 catalytic residues [active] 326424010996 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 326424010997 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326424010998 DNA-binding site [nucleotide binding]; DNA binding site 326424010999 UTRA domain; Region: UTRA; pfam07702 326424011000 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 326424011001 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 326424011002 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326424011003 catalytic residue [active] 326424011004 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 326424011005 substrate binding site [chemical binding]; other site 326424011006 active site 326424011007 catalytic residues [active] 326424011008 heterodimer interface [polypeptide binding]; other site 326424011009 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 326424011010 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 326424011011 ATP-grasp domain; Region: ATP-grasp_4; cl17255 326424011012 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 326424011013 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 326424011014 ATP-grasp domain; Region: ATP-grasp_4; cl17255 326424011015 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 326424011016 IMP binding site; other site 326424011017 dimer interface [polypeptide binding]; other site 326424011018 interdomain contacts; other site 326424011019 partial ornithine binding site; other site 326424011020 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 326424011021 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 326424011022 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 326424011023 catalytic site [active] 326424011024 subunit interface [polypeptide binding]; other site 326424011025 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 326424011026 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 326424011027 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 326424011028 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 326424011029 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 326424011030 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 326424011031 catalytic triad [active] 326424011032 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424011033 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 326424011034 NAD(P) binding site [chemical binding]; other site 326424011035 active site 326424011036 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 326424011037 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 326424011038 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326424011039 DNA-binding site [nucleotide binding]; DNA binding site 326424011040 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326424011041 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326424011042 homodimer interface [polypeptide binding]; other site 326424011043 catalytic residue [active] 326424011044 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 326424011045 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424011046 S-adenosylmethionine binding site [chemical binding]; other site 326424011047 Condensation domain; Region: Condensation; pfam00668 326424011048 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 326424011049 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 326424011050 active site 2 [active] 326424011051 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 326424011052 active site 2 [active] 326424011053 active site 1 [active] 326424011054 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 326424011055 classical (c) SDRs; Region: SDR_c; cd05233 326424011056 NAD(P) binding site [chemical binding]; other site 326424011057 active site 326424011058 enoyl-CoA hydratase; Provisional; Region: PRK06495 326424011059 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424011060 substrate binding site [chemical binding]; other site 326424011061 oxyanion hole (OAH) forming residues; other site 326424011062 trimer interface [polypeptide binding]; other site 326424011063 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 326424011064 short chain dehydrogenase; Provisional; Region: PRK06172 326424011065 classical (c) SDRs; Region: SDR_c; cd05233 326424011066 NAD(P) binding site [chemical binding]; other site 326424011067 active site 326424011068 enoyl-CoA hydratase; Provisional; Region: PRK06210 326424011069 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424011070 substrate binding site [chemical binding]; other site 326424011071 oxyanion hole (OAH) forming residues; other site 326424011072 trimer interface [polypeptide binding]; other site 326424011073 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 326424011074 DinB superfamily; Region: DinB_2; pfam12867 326424011075 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424011076 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424011077 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 326424011078 classical (c) SDRs; Region: SDR_c; cd05233 326424011079 NAD(P) binding site [chemical binding]; other site 326424011080 active site 326424011081 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 326424011082 CGNR zinc finger; Region: zf-CGNR; pfam11706 326424011083 Cupin domain; Region: Cupin_2; cl17218 326424011084 TIR domain; Region: TIR_2; pfam13676 326424011085 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424011086 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 326424011087 Walker A/P-loop; other site 326424011088 ATP binding site [chemical binding]; other site 326424011089 Q-loop/lid; other site 326424011090 ABC transporter signature motif; other site 326424011091 Walker B; other site 326424011092 D-loop; other site 326424011093 H-loop/switch region; other site 326424011094 Part of AAA domain; Region: AAA_19; pfam13245 326424011095 Family description; Region: UvrD_C_2; pfam13538 326424011096 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 326424011097 Sulfate transporter family; Region: Sulfate_transp; pfam00916 326424011098 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 326424011099 active site clefts [active] 326424011100 zinc binding site [ion binding]; other site 326424011101 dimer interface [polypeptide binding]; other site 326424011102 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 326424011103 zinc binding site [ion binding]; other site 326424011104 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 326424011105 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326424011106 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326424011107 active site 326424011108 catalytic tetrad [active] 326424011109 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 326424011110 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 326424011111 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424011112 Walker A/P-loop; other site 326424011113 ATP binding site [chemical binding]; other site 326424011114 Q-loop/lid; other site 326424011115 ABC transporter signature motif; other site 326424011116 Walker B; other site 326424011117 D-loop; other site 326424011118 H-loop/switch region; other site 326424011119 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424011120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424011121 active site 326424011122 phosphorylation site [posttranslational modification] 326424011123 intermolecular recognition site; other site 326424011124 dimerization interface [polypeptide binding]; other site 326424011125 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326424011126 dimerization interface [polypeptide binding]; other site 326424011127 DNA binding residues [nucleotide binding] 326424011128 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 326424011129 Predicted ATPase [General function prediction only]; Region: COG3899 326424011130 clavulanic acid dehydrogenase (CAD), classical (c) SDR; Region: CAD_SDR_c; cd08934 326424011131 NADP binding site [chemical binding]; other site 326424011132 homotetramer interface [polypeptide binding]; other site 326424011133 homodimer interface [polypeptide binding]; other site 326424011134 active site 326424011135 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424011136 S-adenosylmethionine binding site [chemical binding]; other site 326424011137 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 326424011138 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424011139 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 326424011140 putative active site [active] 326424011141 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 326424011142 RNA binding surface [nucleotide binding]; other site 326424011143 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 326424011144 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424011145 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326424011146 putative substrate translocation pore; other site 326424011147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424011148 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 326424011149 Ligand Binding Site [chemical binding]; other site 326424011150 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 326424011151 Ligand Binding Site [chemical binding]; other site 326424011152 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 326424011153 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 326424011154 GAF domain; Region: GAF; cl17456 326424011155 Histidine kinase; Region: HisKA_3; pfam07730 326424011156 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 326424011157 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 326424011158 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 326424011159 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424011160 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 326424011161 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 326424011162 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424011163 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424011164 Domain of unknown function (DUF427); Region: DUF427; pfam04248 326424011165 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 326424011166 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 326424011167 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 326424011168 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 326424011169 catalytic Zn binding site [ion binding]; other site 326424011170 NAD binding site [chemical binding]; other site 326424011171 structural Zn binding site [ion binding]; other site 326424011172 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 326424011173 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 326424011174 NAD(P) binding site [chemical binding]; other site 326424011175 catalytic residues [active] 326424011176 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 326424011177 extended (e) SDRs; Region: SDR_e; cd08946 326424011178 NAD(P) binding site [chemical binding]; other site 326424011179 active site 326424011180 substrate binding site [chemical binding]; other site 326424011181 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326424011182 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326424011183 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 326424011184 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 326424011185 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 326424011186 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 326424011187 CoA-transferase family III; Region: CoA_transf_3; pfam02515 326424011188 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 326424011189 CoA-transferase family III; Region: CoA_transf_3; pfam02515 326424011190 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 326424011191 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 326424011192 active site 326424011193 enoyl-CoA hydratase; Provisional; Region: PRK06494 326424011194 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424011195 substrate binding site [chemical binding]; other site 326424011196 oxyanion hole (OAH) forming residues; other site 326424011197 trimer interface [polypeptide binding]; other site 326424011198 enoyl-CoA hydratase; Provisional; Region: PRK05864 326424011199 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424011200 substrate binding site [chemical binding]; other site 326424011201 oxyanion hole (OAH) forming residues; other site 326424011202 trimer interface [polypeptide binding]; other site 326424011203 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 326424011204 active site 326424011205 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 326424011206 catalytic triad [active] 326424011207 dimer interface [polypeptide binding]; other site 326424011208 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 326424011209 CoA-transferase family III; Region: CoA_transf_3; pfam02515 326424011210 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424011211 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 326424011212 active site 326424011213 Phosphotransferase enzyme family; Region: APH; pfam01636 326424011214 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 326424011215 putative active site [active] 326424011216 putative substrate binding site [chemical binding]; other site 326424011217 ATP binding site [chemical binding]; other site 326424011218 enoyl-CoA hydratase; Provisional; Region: PRK06190 326424011219 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424011220 substrate binding site [chemical binding]; other site 326424011221 oxyanion hole (OAH) forming residues; other site 326424011222 trimer interface [polypeptide binding]; other site 326424011223 enoyl-CoA hydratase; Provisional; Region: PRK06142 326424011224 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424011225 substrate binding site [chemical binding]; other site 326424011226 oxyanion hole (OAH) forming residues; other site 326424011227 trimer interface [polypeptide binding]; other site 326424011228 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 326424011229 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424011230 NAD(P) binding site [chemical binding]; other site 326424011231 active site 326424011232 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 326424011233 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 326424011234 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 326424011235 enoyl-CoA hydratase; Provisional; Region: PRK06190 326424011236 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424011237 substrate binding site [chemical binding]; other site 326424011238 oxyanion hole (OAH) forming residues; other site 326424011239 trimer interface [polypeptide binding]; other site 326424011240 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326424011241 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326424011242 active site 326424011243 catalytic tetrad [active] 326424011244 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 326424011245 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 326424011246 NAD binding site [chemical binding]; other site 326424011247 homodimer interface [polypeptide binding]; other site 326424011248 homotetramer interface [polypeptide binding]; other site 326424011249 active site 326424011250 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 326424011251 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 326424011252 CoenzymeA binding site [chemical binding]; other site 326424011253 subunit interaction site [polypeptide binding]; other site 326424011254 PHB binding site; other site 326424011255 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 326424011256 CoenzymeA binding site [chemical binding]; other site 326424011257 subunit interaction site [polypeptide binding]; other site 326424011258 PHB binding site; other site 326424011259 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 326424011260 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 326424011261 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 326424011262 DNA binding residues [nucleotide binding] 326424011263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424011264 putative substrate translocation pore; other site 326424011265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424011266 putative substrate translocation pore; other site 326424011267 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424011268 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424011269 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 326424011270 active site 326424011271 TDP-binding site; other site 326424011272 acceptor substrate-binding pocket; other site 326424011273 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424011274 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 326424011275 hypothetical protein; Provisional; Region: PRK06126 326424011276 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 326424011277 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 326424011278 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 326424011279 active site 326424011280 non-prolyl cis peptide bond; other site 326424011281 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 326424011282 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326424011283 Walker A/P-loop; other site 326424011284 ATP binding site [chemical binding]; other site 326424011285 Q-loop/lid; other site 326424011286 ABC transporter signature motif; other site 326424011287 Walker B; other site 326424011288 D-loop; other site 326424011289 H-loop/switch region; other site 326424011290 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 326424011291 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 326424011292 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326424011293 Walker A/P-loop; other site 326424011294 ATP binding site [chemical binding]; other site 326424011295 Q-loop/lid; other site 326424011296 ABC transporter signature motif; other site 326424011297 Walker B; other site 326424011298 D-loop; other site 326424011299 H-loop/switch region; other site 326424011300 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 326424011301 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 326424011302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424011303 dimer interface [polypeptide binding]; other site 326424011304 conserved gate region; other site 326424011305 ABC-ATPase subunit interface; other site 326424011306 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 326424011307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424011308 dimer interface [polypeptide binding]; other site 326424011309 conserved gate region; other site 326424011310 putative PBP binding loops; other site 326424011311 ABC-ATPase subunit interface; other site 326424011312 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_9; cd08496 326424011313 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 326424011314 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 326424011315 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 326424011316 active site 326424011317 non-prolyl cis peptide bond; other site 326424011318 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326424011319 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 326424011320 dimerization interface [polypeptide binding]; other site 326424011321 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 326424011322 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424011323 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424011324 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424011325 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 326424011326 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 326424011327 CoA-transferase family III; Region: CoA_transf_3; pfam02515 326424011328 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 326424011329 CoA-transferase family III; Region: CoA_transf_3; pfam02515 326424011330 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 326424011331 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 326424011332 Walker A/P-loop; other site 326424011333 ATP binding site [chemical binding]; other site 326424011334 Q-loop/lid; other site 326424011335 ABC transporter signature motif; other site 326424011336 Walker B; other site 326424011337 D-loop; other site 326424011338 H-loop/switch region; other site 326424011339 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 326424011340 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 326424011341 Part of AAA domain; Region: AAA_19; pfam13245 326424011342 Family description; Region: UvrD_C_2; pfam13538 326424011343 Histidine kinase; Region: HisKA_3; pfam07730 326424011344 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424011345 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424011346 active site 326424011347 phosphorylation site [posttranslational modification] 326424011348 intermolecular recognition site; other site 326424011349 dimerization interface [polypeptide binding]; other site 326424011350 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326424011351 DNA binding residues [nucleotide binding] 326424011352 dimerization interface [polypeptide binding]; other site 326424011353 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 326424011354 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 326424011355 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 326424011356 Na binding site [ion binding]; other site 326424011357 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 326424011358 homotetrameric interface [polypeptide binding]; other site 326424011359 putative active site [active] 326424011360 metal binding site [ion binding]; metal-binding site 326424011361 bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional; Region: PRK13982 326424011362 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 326424011363 active site 326424011364 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 326424011365 amidohydrolase; Region: amidohydrolases; TIGR01891 326424011366 metal binding site [ion binding]; metal-binding site 326424011367 dimer interface [polypeptide binding]; other site 326424011368 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424011369 sequence-specific DNA binding site [nucleotide binding]; other site 326424011370 salt bridge; other site 326424011371 Cupin domain; Region: Cupin_2; pfam07883 326424011372 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 326424011373 nudix motif; other site 326424011374 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 326424011375 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 326424011376 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424011377 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 326424011378 NAD(P) binding site [chemical binding]; other site 326424011379 active site 326424011380 Cupin domain; Region: Cupin_2; pfam07883 326424011381 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 326424011382 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 326424011383 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 326424011384 catalytic Zn binding site [ion binding]; other site 326424011385 NAD(P) binding site [chemical binding]; other site 326424011386 structural Zn binding site [ion binding]; other site 326424011387 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 326424011388 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 326424011389 active site 326424011390 dimer interface [polypeptide binding]; other site 326424011391 non-prolyl cis peptide bond; other site 326424011392 insertion regions; other site 326424011393 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 326424011394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 326424011395 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 326424011396 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 326424011397 active site 326424011398 non-prolyl cis peptide bond; other site 326424011399 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 326424011400 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 326424011401 active site 326424011402 non-prolyl cis peptide bond; other site 326424011403 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 326424011404 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424011405 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326424011406 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 326424011407 Walker A/P-loop; other site 326424011408 ATP binding site [chemical binding]; other site 326424011409 Q-loop/lid; other site 326424011410 ABC transporter signature motif; other site 326424011411 Walker B; other site 326424011412 D-loop; other site 326424011413 H-loop/switch region; other site 326424011414 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 326424011415 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 326424011416 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326424011417 Walker A/P-loop; other site 326424011418 ATP binding site [chemical binding]; other site 326424011419 Q-loop/lid; other site 326424011420 ABC transporter signature motif; other site 326424011421 Walker B; other site 326424011422 D-loop; other site 326424011423 H-loop/switch region; other site 326424011424 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 326424011425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 326424011426 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 326424011427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424011428 dimer interface [polypeptide binding]; other site 326424011429 conserved gate region; other site 326424011430 putative PBP binding loops; other site 326424011431 ABC-ATPase subunit interface; other site 326424011432 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 326424011433 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 326424011434 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 326424011435 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 326424011436 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 326424011437 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 326424011438 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 326424011439 homodimer interface [polypeptide binding]; other site 326424011440 substrate-cofactor binding pocket; other site 326424011441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326424011442 catalytic residue [active] 326424011443 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 326424011444 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 326424011445 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 326424011446 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424011447 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 326424011448 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 326424011449 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 326424011450 putative NAD(P) binding site [chemical binding]; other site 326424011451 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 326424011452 hypothetical protein; Provisional; Region: PRK07906 326424011453 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 326424011454 putative metal binding site [ion binding]; other site 326424011455 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 326424011456 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 326424011457 PAS fold; Region: PAS_3; pfam08447 326424011458 putative active site [active] 326424011459 heme pocket [chemical binding]; other site 326424011460 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 326424011461 GAF domain; Region: GAF; pfam01590 326424011462 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 326424011463 Transcriptional regulators [Transcription]; Region: FadR; COG2186 326424011464 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326424011465 DNA-binding site [nucleotide binding]; DNA binding site 326424011466 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 326424011467 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 326424011468 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424011469 substrate binding site [chemical binding]; other site 326424011470 oxyanion hole (OAH) forming residues; other site 326424011471 trimer interface [polypeptide binding]; other site 326424011472 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 326424011473 Ligand binding site; other site 326424011474 Ligand binding site; other site 326424011475 Ligand binding site; other site 326424011476 Putative Catalytic site; other site 326424011477 DXD motif; other site 326424011478 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 326424011479 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 326424011480 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424011481 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326424011482 DNA binding residues [nucleotide binding] 326424011483 dimerization interface [polypeptide binding]; other site 326424011484 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 326424011485 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 326424011486 putative ligand binding site [chemical binding]; other site 326424011487 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 326424011488 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 326424011489 Walker A/P-loop; other site 326424011490 ATP binding site [chemical binding]; other site 326424011491 Q-loop/lid; other site 326424011492 ABC transporter signature motif; other site 326424011493 Walker B; other site 326424011494 D-loop; other site 326424011495 H-loop/switch region; other site 326424011496 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 326424011497 TM-ABC transporter signature motif; other site 326424011498 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 326424011499 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 326424011500 TM-ABC transporter signature motif; other site 326424011501 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 326424011502 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 326424011503 Walker A/P-loop; other site 326424011504 ATP binding site [chemical binding]; other site 326424011505 Q-loop/lid; other site 326424011506 ABC transporter signature motif; other site 326424011507 Walker B; other site 326424011508 D-loop; other site 326424011509 H-loop/switch region; other site 326424011510 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 326424011511 active site 326424011512 catalytic site [active] 326424011513 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 326424011514 active site 2 [active] 326424011515 active site 1 [active] 326424011516 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 326424011517 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 326424011518 putative ligand binding site [chemical binding]; other site 326424011519 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424011520 NAD(P) binding site [chemical binding]; other site 326424011521 active site 326424011522 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 326424011523 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424011524 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424011525 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424011526 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424011527 active site 326424011528 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424011529 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424011530 active site 326424011531 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 326424011532 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424011533 AMP binding site [chemical binding]; other site 326424011534 active site 326424011535 acyl-activating enzyme (AAE) consensus motif; other site 326424011536 CoA binding site [chemical binding]; other site 326424011537 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424011538 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424011539 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424011540 active site 326424011541 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 326424011542 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 326424011543 Transcriptional regulators [Transcription]; Region: FadR; COG2186 326424011544 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326424011545 DNA-binding site [nucleotide binding]; DNA binding site 326424011546 FCD domain; Region: FCD; pfam07729 326424011547 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 326424011548 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 326424011549 DUF35 OB-fold domain; Region: DUF35; pfam01796 326424011550 lipid-transfer protein; Provisional; Region: PRK07855 326424011551 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 326424011552 active site 326424011553 Amidohydrolase; Region: Amidohydro_2; pfam04909 326424011554 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 326424011555 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424011556 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424011557 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424011558 acyl-activating enzyme (AAE) consensus motif; other site 326424011559 acyl-activating enzyme (AAE) consensus motif; other site 326424011560 AMP binding site [chemical binding]; other site 326424011561 active site 326424011562 CoA binding site [chemical binding]; other site 326424011563 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424011564 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424011565 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424011566 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 326424011567 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 326424011568 active site 326424011569 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 326424011570 Phosphotransferase enzyme family; Region: APH; pfam01636 326424011571 putative active site [active] 326424011572 putative substrate binding site [chemical binding]; other site 326424011573 ATP binding site [chemical binding]; other site 326424011574 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 326424011575 active site 326424011576 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 326424011577 non-prolyl cis peptide bond; other site 326424011578 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424011579 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424011580 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 326424011581 Dienelactone hydrolase family; Region: DLH; pfam01738 326424011582 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 326424011583 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 326424011584 active site clefts [active] 326424011585 zinc binding site [ion binding]; other site 326424011586 dimer interface [polypeptide binding]; other site 326424011587 Predicted transcriptional regulators [Transcription]; Region: COG1733 326424011588 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326424011589 dimerization interface [polypeptide binding]; other site 326424011590 putative DNA binding site [nucleotide binding]; other site 326424011591 putative Zn2+ binding site [ion binding]; other site 326424011592 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 326424011593 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 326424011594 putative NAD(P) binding site [chemical binding]; other site 326424011595 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424011596 S-adenosylmethionine binding site [chemical binding]; other site 326424011597 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 326424011598 amidase catalytic site [active] 326424011599 Zn binding residues [ion binding]; other site 326424011600 substrate binding site [chemical binding]; other site 326424011601 ChaB; Region: ChaB; pfam06150 326424011602 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 326424011603 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 326424011604 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 326424011605 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 326424011606 putative acyl-acceptor binding pocket; other site 326424011607 GAF domain; Region: GAF; pfam01590 326424011608 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424011609 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326424011610 DNA binding residues [nucleotide binding] 326424011611 dimerization interface [polypeptide binding]; other site 326424011612 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 326424011613 RNase_H superfamily; Region: RNase_H_2; pfam13482 326424011614 Part of AAA domain; Region: AAA_19; pfam13245 326424011615 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 326424011616 AAA domain; Region: AAA_12; pfam13087 326424011617 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 326424011618 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 326424011619 CoA binding domain; Region: CoA_binding_2; pfam13380 326424011620 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 326424011621 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 326424011622 prephenate dehydratase; Provisional; Region: PRK11899 326424011623 Prephenate dehydratase; Region: PDT; pfam00800 326424011624 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 326424011625 putative L-Phe binding site [chemical binding]; other site 326424011626 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 326424011627 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 326424011628 Thioredoxin; Region: Thioredoxin_4; cl17273 326424011629 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 326424011630 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 326424011631 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 326424011632 active site 326424011633 dimer interface [polypeptide binding]; other site 326424011634 effector binding site; other site 326424011635 Domain of unknown function (DUF222); Region: DUF222; pfam02720 326424011636 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 326424011637 putative active site [active] 326424011638 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 326424011639 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 326424011640 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 326424011641 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 326424011642 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 326424011643 putative active site [active] 326424011644 putative CoA binding site [chemical binding]; other site 326424011645 nudix motif; other site 326424011646 metal binding site [ion binding]; metal-binding site 326424011647 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 326424011648 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 326424011649 NodB motif; other site 326424011650 active site 326424011651 catalytic site [active] 326424011652 metal binding site [ion binding]; metal-binding site 326424011653 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 326424011654 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 326424011655 FAD binding pocket [chemical binding]; other site 326424011656 FAD binding motif [chemical binding]; other site 326424011657 phosphate binding motif [ion binding]; other site 326424011658 beta-alpha-beta structure motif; other site 326424011659 NAD binding pocket [chemical binding]; other site 326424011660 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 326424011661 Moco binding site; other site 326424011662 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 326424011663 metal coordination site [ion binding]; other site 326424011664 Transcriptional regulators [Transcription]; Region: FadR; COG2186 326424011665 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326424011666 DNA-binding site [nucleotide binding]; DNA binding site 326424011667 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 326424011668 active site 326424011669 putative homodimer interface [polypeptide binding]; other site 326424011670 SAM binding site [chemical binding]; other site 326424011671 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 326424011672 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424011673 S-adenosylmethionine binding site [chemical binding]; other site 326424011674 acyl-CoA synthetase; Validated; Region: PRK07787 326424011675 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424011676 acyl-activating enzyme (AAE) consensus motif; other site 326424011677 AMP binding site [chemical binding]; other site 326424011678 active site 326424011679 CoA binding site [chemical binding]; other site 326424011680 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326424011681 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 326424011682 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 326424011683 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424011684 Walker A/P-loop; other site 326424011685 ATP binding site [chemical binding]; other site 326424011686 Q-loop/lid; other site 326424011687 ABC transporter signature motif; other site 326424011688 Walker B; other site 326424011689 D-loop; other site 326424011690 H-loop/switch region; other site 326424011691 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 326424011692 Asparagine synthase; Region: Asn_synthase; pfam00733 326424011693 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 326424011694 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 326424011695 N-acetyl-D-glucosamine binding site [chemical binding]; other site 326424011696 catalytic residue [active] 326424011697 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 326424011698 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 326424011699 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 326424011700 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 326424011701 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 326424011702 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 326424011703 active site 326424011704 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 326424011705 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424011706 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 326424011707 S-adenosylmethionine synthetase; Validated; Region: PRK05250 326424011708 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 326424011709 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 326424011710 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 326424011711 Domain of unknown function (DUF309); Region: DUF309; pfam03745 326424011712 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 326424011713 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 326424011714 dimer interface [polypeptide binding]; other site 326424011715 active site 326424011716 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424011717 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424011718 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 326424011719 Domain of unknown function DUF21; Region: DUF21; pfam01595 326424011720 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 326424011721 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 326424011722 Transporter associated domain; Region: CorC_HlyC; smart01091 326424011723 Domain of unknown function DUF21; Region: DUF21; pfam01595 326424011724 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 326424011725 FOG: CBS domain [General function prediction only]; Region: COG0517 326424011726 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424011727 S-adenosylmethionine binding site [chemical binding]; other site 326424011728 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 326424011729 nucleotide binding site [chemical binding]; other site 326424011730 PBP superfamily domain; Region: PBP_like_2; cl17296 326424011731 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 326424011732 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424011733 active site 326424011734 ATP binding site [chemical binding]; other site 326424011735 substrate binding site [chemical binding]; other site 326424011736 activation loop (A-loop); other site 326424011737 FOG: WD40 repeat [General function prediction only]; Region: COG2319 326424011738 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 326424011739 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 326424011740 nucleotide binding site [chemical binding]; other site 326424011741 PBP superfamily domain; Region: PBP_like_2; cl17296 326424011742 membrane ATPase/protein kinase; Provisional; Region: PRK09435 326424011743 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 326424011744 Walker A; other site 326424011745 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 326424011746 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 326424011747 active site 326424011748 substrate binding site [chemical binding]; other site 326424011749 coenzyme B12 binding site [chemical binding]; other site 326424011750 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 326424011751 B12 binding site [chemical binding]; other site 326424011752 cobalt ligand [ion binding]; other site 326424011753 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 326424011754 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 326424011755 heterodimer interface [polypeptide binding]; other site 326424011756 substrate interaction site [chemical binding]; other site 326424011757 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 326424011758 Secretory lipase; Region: LIP; pfam03583 326424011759 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 326424011760 Cu(I) binding site [ion binding]; other site 326424011761 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 326424011762 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 326424011763 Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250 326424011764 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 326424011765 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 326424011766 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 326424011767 DXD motif; other site 326424011768 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 326424011769 tellurite resistance protein terB; Region: terB; cd07176 326424011770 putative metal binding site [ion binding]; other site 326424011771 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 326424011772 active site 326424011773 catalytic site [active] 326424011774 adenylate kinase; Reviewed; Region: adk; PRK00279 326424011775 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 326424011776 AMP-binding site [chemical binding]; other site 326424011777 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 326424011778 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 326424011779 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 326424011780 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 326424011781 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 326424011782 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 326424011783 active site 326424011784 dimer interface [polypeptide binding]; other site 326424011785 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 326424011786 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 326424011787 active site 326424011788 FMN binding site [chemical binding]; other site 326424011789 substrate binding site [chemical binding]; other site 326424011790 3Fe-4S cluster binding site [ion binding]; other site 326424011791 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 326424011792 domain interface; other site 326424011793 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 326424011794 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 326424011795 substrate binding site [chemical binding]; other site 326424011796 active site 326424011797 catalytic residues [active] 326424011798 heterodimer interface [polypeptide binding]; other site 326424011799 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 326424011800 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 326424011801 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326424011802 catalytic residue [active] 326424011803 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 326424011804 active site 326424011805 ribulose/triose binding site [chemical binding]; other site 326424011806 phosphate binding site [ion binding]; other site 326424011807 substrate (anthranilate) binding pocket [chemical binding]; other site 326424011808 product (indole) binding pocket [chemical binding]; other site 326424011809 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 326424011810 anthranilate synthase component I; Provisional; Region: PRK13571 326424011811 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 326424011812 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 326424011813 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 326424011814 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326424011815 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424011816 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 326424011817 Walker A/P-loop; other site 326424011818 ATP binding site [chemical binding]; other site 326424011819 Q-loop/lid; other site 326424011820 ABC transporter signature motif; other site 326424011821 Walker B; other site 326424011822 D-loop; other site 326424011823 H-loop/switch region; other site 326424011824 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 326424011825 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326424011826 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424011827 Walker A/P-loop; other site 326424011828 ATP binding site [chemical binding]; other site 326424011829 Q-loop/lid; other site 326424011830 ABC transporter signature motif; other site 326424011831 Walker B; other site 326424011832 D-loop; other site 326424011833 H-loop/switch region; other site 326424011834 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 326424011835 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 326424011836 substrate binding site [chemical binding]; other site 326424011837 glutamase interaction surface [polypeptide binding]; other site 326424011838 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 326424011839 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 326424011840 catalytic residues [active] 326424011841 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326424011842 Coenzyme A binding pocket [chemical binding]; other site 326424011843 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 326424011844 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424011845 non-specific DNA binding site [nucleotide binding]; other site 326424011846 salt bridge; other site 326424011847 sequence-specific DNA binding site [nucleotide binding]; other site 326424011848 Domain of unknown function (DUF955); Region: DUF955; pfam06114 326424011849 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 326424011850 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 326424011851 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 326424011852 ThiF family; Region: ThiF; pfam00899 326424011853 ATP binding site [chemical binding]; other site 326424011854 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 326424011855 HsdM N-terminal domain; Region: HsdM_N; pfam12161 326424011856 Methyltransferase domain; Region: Methyltransf_26; pfam13659 326424011857 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 326424011858 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 326424011859 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 326424011860 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 326424011861 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326424011862 ATP binding site [chemical binding]; other site 326424011863 putative Mg++ binding site [ion binding]; other site 326424011864 Protein of unknown function DUF45; Region: DUF45; pfam01863 326424011865 TIR domain; Region: TIR_2; pfam13676 326424011866 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 326424011867 TPR motif; other site 326424011868 binding surface 326424011869 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424011870 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424011871 Tetratricopeptide repeat; Region: TPR_10; cl17452 326424011872 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424011873 Tetratricopeptide repeat; Region: TPR_10; pfam13374 326424011874 Domain of unknown function DUF302; Region: DUF302; cl01364 326424011875 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 326424011876 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 326424011877 putative active site [active] 326424011878 oxyanion strand; other site 326424011879 catalytic triad [active] 326424011880 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 326424011881 putative active site pocket [active] 326424011882 4-fold oligomerization interface [polypeptide binding]; other site 326424011883 metal binding residues [ion binding]; metal-binding site 326424011884 3-fold/trimer interface [polypeptide binding]; other site 326424011885 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 326424011886 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326424011887 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326424011888 homodimer interface [polypeptide binding]; other site 326424011889 catalytic residue [active] 326424011890 histidinol dehydrogenase; Region: hisD; TIGR00069 326424011891 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 326424011892 NAD binding site [chemical binding]; other site 326424011893 dimerization interface [polypeptide binding]; other site 326424011894 product binding site; other site 326424011895 substrate binding site [chemical binding]; other site 326424011896 zinc binding site [ion binding]; other site 326424011897 catalytic residues [active] 326424011898 Protein of unknown function DUF43; Region: DUF43; pfam01861 326424011899 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326424011900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424011901 active site 326424011902 phosphorylation site [posttranslational modification] 326424011903 intermolecular recognition site; other site 326424011904 dimerization interface [polypeptide binding]; other site 326424011905 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326424011906 DNA binding site [nucleotide binding] 326424011907 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326424011908 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 326424011909 dimerization interface [polypeptide binding]; other site 326424011910 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326424011911 dimer interface [polypeptide binding]; other site 326424011912 phosphorylation site [posttranslational modification] 326424011913 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424011914 Mg2+ binding site [ion binding]; other site 326424011915 G-X-G motif; other site 326424011916 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424011917 ATP binding site [chemical binding]; other site 326424011918 G-X-G motif; other site 326424011919 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 326424011920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 326424011921 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 326424011922 Uncharacterized conserved protein [Function unknown]; Region: COG2128 326424011923 classical (c) SDRs; Region: SDR_c; cd05233 326424011924 NAD(P) binding site [chemical binding]; other site 326424011925 active site 326424011926 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 326424011927 TAP-like protein; Region: Abhydrolase_4; pfam08386 326424011928 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 326424011929 Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706 326424011930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424011931 S-adenosylmethionine binding site [chemical binding]; other site 326424011932 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 326424011933 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 326424011934 heme-binding site [chemical binding]; other site 326424011935 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 326424011936 FAD binding pocket [chemical binding]; other site 326424011937 FAD binding motif [chemical binding]; other site 326424011938 phosphate binding motif [ion binding]; other site 326424011939 beta-alpha-beta structure motif; other site 326424011940 NAD binding pocket [chemical binding]; other site 326424011941 Heme binding pocket [chemical binding]; other site 326424011942 TIR domain; Region: TIR_2; pfam13676 326424011943 CCC1-related family of proteins; Region: CCC1_like; cl00278 326424011944 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 326424011945 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 326424011946 tetramer interface [polypeptide binding]; other site 326424011947 active site 326424011948 Mg2+/Mn2+ binding site [ion binding]; other site 326424011949 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 326424011950 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 326424011951 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 326424011952 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 326424011953 calcium binding site 2 [ion binding]; other site 326424011954 active site 326424011955 catalytic triad [active] 326424011956 calcium binding site 1 [ion binding]; other site 326424011957 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 326424011958 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 326424011959 putative ligand binding site [chemical binding]; other site 326424011960 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 326424011961 TM-ABC transporter signature motif; other site 326424011962 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 326424011963 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 326424011964 TM-ABC transporter signature motif; other site 326424011965 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 326424011966 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 326424011967 Walker A/P-loop; other site 326424011968 ATP binding site [chemical binding]; other site 326424011969 Q-loop/lid; other site 326424011970 ABC transporter signature motif; other site 326424011971 Walker B; other site 326424011972 D-loop; other site 326424011973 H-loop/switch region; other site 326424011974 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 326424011975 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 326424011976 Walker A/P-loop; other site 326424011977 ATP binding site [chemical binding]; other site 326424011978 Q-loop/lid; other site 326424011979 ABC transporter signature motif; other site 326424011980 Walker B; other site 326424011981 D-loop; other site 326424011982 H-loop/switch region; other site 326424011983 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 326424011984 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 326424011985 Lamin Tail Domain; Region: LTD; pfam00932 326424011986 SdiA-regulated; Region: SdiA-regulated; cd09971 326424011987 putative active site [active] 326424011988 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 326424011989 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 326424011990 sequence-specific DNA binding site [nucleotide binding]; other site 326424011991 salt bridge; other site 326424011992 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 326424011993 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424011994 S-adenosylmethionine binding site [chemical binding]; other site 326424011995 hypothetical protein; Region: PHA02099 326424011996 Protein of unknown function (DUF3494); Region: DUF3494; pfam11999 326424011997 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 326424011998 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 326424011999 dimer interface [polypeptide binding]; other site 326424012000 catalytic triad [active] 326424012001 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 326424012002 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 326424012003 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 326424012004 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 326424012005 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 326424012006 dimer interface [polypeptide binding]; other site 326424012007 TPP-binding site [chemical binding]; other site 326424012008 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 326424012009 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 326424012010 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 326424012011 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 326424012012 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 326424012013 Ligand binding site; other site 326424012014 Putative Catalytic site; other site 326424012015 DXD motif; other site 326424012016 CoA binding domain; Region: CoA_binding; cl17356 326424012017 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 326424012018 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 326424012019 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326424012020 motif II; other site 326424012021 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 326424012022 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 326424012023 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 326424012024 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 326424012025 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 326424012026 putative metal binding site [ion binding]; other site 326424012027 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 326424012028 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 326424012029 CoenzymeA binding site [chemical binding]; other site 326424012030 subunit interaction site [polypeptide binding]; other site 326424012031 PHB binding site; other site 326424012032 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 326424012033 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 326424012034 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 326424012035 active site 326424012036 thiamine phosphate binding site [chemical binding]; other site 326424012037 pyrophosphate binding site [ion binding]; other site 326424012038 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 326424012039 thiS-thiF/thiG interaction site; other site 326424012040 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 326424012041 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 326424012042 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 326424012043 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326424012044 FeS/SAM binding site; other site 326424012045 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 326424012046 thiazole synthase; Reviewed; Region: thiG; PRK00208 326424012047 phosphate binding site [ion binding]; other site 326424012048 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424012049 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424012050 active site 326424012051 ATP binding site [chemical binding]; other site 326424012052 substrate binding site [chemical binding]; other site 326424012053 activation loop (A-loop); other site 326424012054 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 326424012055 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 326424012056 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 326424012057 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 326424012058 phosphofructokinase; Region: PFK_mixed; TIGR02483 326424012059 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 326424012060 active site 326424012061 ADP/pyrophosphate binding site [chemical binding]; other site 326424012062 dimerization interface [polypeptide binding]; other site 326424012063 allosteric effector site; other site 326424012064 fructose-1,6-bisphosphate binding site; other site 326424012065 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 326424012066 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 326424012067 putative acyl-acceptor binding pocket; other site 326424012068 Esterase/lipase [General function prediction only]; Region: COG1647 326424012069 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144 326424012070 Uncharacterized conserved protein [Function unknown]; Region: COG1915 326424012071 homodimer interface [polypeptide binding]; other site 326424012072 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 326424012073 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 326424012074 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 326424012075 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 326424012076 DTAP/Switch II; other site 326424012077 Switch I; other site 326424012078 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 326424012079 putative hydrophobic ligand binding site [chemical binding]; other site 326424012080 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 326424012081 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 326424012082 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 326424012083 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 326424012084 acyl-activating enzyme (AAE) consensus motif; other site 326424012085 putative AMP binding site [chemical binding]; other site 326424012086 putative active site [active] 326424012087 putative CoA binding site [chemical binding]; other site 326424012088 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326424012089 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 326424012090 YacP-like NYN domain; Region: NYN_YacP; cl01491 326424012091 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 326424012092 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 326424012093 nucleotide binding site/active site [active] 326424012094 HIT family signature motif; other site 326424012095 catalytic residue [active] 326424012096 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 326424012097 hypothetical protein; Validated; Region: PRK07883 326424012098 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 326424012099 active site 326424012100 catalytic site [active] 326424012101 substrate binding site [chemical binding]; other site 326424012102 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 326424012103 GIY-YIG motif/motif A; other site 326424012104 active site 326424012105 catalytic site [active] 326424012106 putative DNA binding site [nucleotide binding]; other site 326424012107 metal binding site [ion binding]; metal-binding site 326424012108 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 326424012109 heme bH binding site [chemical binding]; other site 326424012110 Qi binding site; other site 326424012111 intrachain domain interface; other site 326424012112 heme bL binding site [chemical binding]; other site 326424012113 interchain domain interface [polypeptide binding]; other site 326424012114 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 326424012115 Qo binding site; other site 326424012116 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 326424012117 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 326424012118 iron-sulfur cluster [ion binding]; other site 326424012119 [2Fe-2S] cluster binding site [ion binding]; other site 326424012120 Cytochrome c; Region: Cytochrom_C; pfam00034 326424012121 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 326424012122 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 326424012123 Subunit I/III interface [polypeptide binding]; other site 326424012124 Protein of unknown function (DUF3501); Region: DUF3501; pfam12007 326424012125 Rubrerythrin [Energy production and conversion]; Region: COG1592 326424012126 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 326424012127 binuclear metal center [ion binding]; other site 326424012128 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 326424012129 metal binding site 2 [ion binding]; metal-binding site 326424012130 putative DNA binding helix; other site 326424012131 metal binding site 1 [ion binding]; metal-binding site 326424012132 dimer interface [polypeptide binding]; other site 326424012133 structural Zn2+ binding site [ion binding]; other site 326424012134 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 326424012135 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 326424012136 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 326424012137 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 326424012138 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 326424012139 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 326424012140 D-pathway; other site 326424012141 Putative ubiquinol binding site [chemical binding]; other site 326424012142 Low-spin heme (heme b) binding site [chemical binding]; other site 326424012143 Putative water exit pathway; other site 326424012144 Binuclear center (heme o3/CuB) [ion binding]; other site 326424012145 K-pathway; other site 326424012146 Putative proton exit pathway; other site 326424012147 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 326424012148 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 326424012149 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 326424012150 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 326424012151 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326424012152 catalytic residue [active] 326424012153 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 326424012154 CPxP motif; other site 326424012155 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 326424012156 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 326424012157 substrate binding site [chemical binding]; other site 326424012158 ATP binding site [chemical binding]; other site 326424012159 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 326424012160 quinolinate synthetase; Provisional; Region: PRK09375 326424012161 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 326424012162 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326424012163 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326424012164 active site 326424012165 catalytic tetrad [active] 326424012166 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424012167 substrate binding site [chemical binding]; other site 326424012168 oxyanion hole (OAH) forming residues; other site 326424012169 trimer interface [polypeptide binding]; other site 326424012170 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424012171 Domain of unknown function (DUF385); Region: DUF385; cl04387 326424012172 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 326424012173 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 326424012174 homotrimer interface [polypeptide binding]; other site 326424012175 Walker A motif; other site 326424012176 GTP binding site [chemical binding]; other site 326424012177 Walker B motif; other site 326424012178 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 326424012179 NB-ARC domain; Region: NB-ARC; pfam00931 326424012180 FOG: WD40 repeat [General function prediction only]; Region: COG2319 326424012181 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 326424012182 structural tetrad; other site 326424012183 FOG: WD40 repeat [General function prediction only]; Region: COG2319 326424012184 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 326424012185 structural tetrad; other site 326424012186 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 326424012187 structural tetrad; other site 326424012188 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 326424012189 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 326424012190 putative dimer interface [polypeptide binding]; other site 326424012191 active site pocket [active] 326424012192 putative cataytic base [active] 326424012193 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 326424012194 putative Zn-ribbon RNA-binding protein; Provisional; Region: PRK14890 326424012195 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 326424012196 metal ion-dependent adhesion site (MIDAS); other site 326424012197 Protein phosphatase 2C; Region: PP2C_2; pfam13672 326424012198 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 326424012199 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 326424012200 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 326424012201 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 326424012202 interface (dimer of trimers) [polypeptide binding]; other site 326424012203 Substrate-binding/catalytic site; other site 326424012204 Zn-binding sites [ion binding]; other site 326424012205 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 326424012206 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326424012207 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 326424012208 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 326424012209 E3 interaction surface; other site 326424012210 lipoyl attachment site [posttranslational modification]; other site 326424012211 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 326424012212 e3 binding domain; Region: E3_binding; pfam02817 326424012213 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 326424012214 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424012215 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 326424012216 NAD(P) binding site [chemical binding]; other site 326424012217 active site 326424012218 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 326424012219 active site pocket [active] 326424012220 oxyanion hole [active] 326424012221 catalytic triad [active] 326424012222 active site nucleophile [active] 326424012223 lipoate-protein ligase B; Provisional; Region: PRK14345 326424012224 lipoyl synthase; Provisional; Region: PRK05481 326424012225 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326424012226 FeS/SAM binding site; other site 326424012227 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 326424012228 RDD family; Region: RDD; pfam06271 326424012229 glutamine synthetase, type I; Region: GlnA; TIGR00653 326424012230 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 326424012231 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 326424012232 glutamine synthetase; Region: PLN02284 326424012233 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 326424012234 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 326424012235 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 326424012236 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 326424012237 metal binding triad; other site 326424012238 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 326424012239 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 326424012240 metal binding triad; other site 326424012241 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 326424012242 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 326424012243 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 326424012244 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 326424012245 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 326424012246 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 326424012247 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 326424012248 active site 326424012249 dimer interface [polypeptide binding]; other site 326424012250 motif 1; other site 326424012251 motif 2; other site 326424012252 motif 3; other site 326424012253 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 326424012254 anticodon binding site; other site 326424012255 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424012256 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424012257 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 326424012258 active site 326424012259 oligomerization interface [polypeptide binding]; other site 326424012260 metal binding site [ion binding]; metal-binding site 326424012261 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 326424012262 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 326424012263 intersubunit interface [polypeptide binding]; other site 326424012264 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 326424012265 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 326424012266 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 326424012267 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 326424012268 active site 326424012269 DNA binding site [nucleotide binding] 326424012270 Int/Topo IB signature motif; other site 326424012271 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 326424012272 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 326424012273 dimer interface [polypeptide binding]; other site 326424012274 active site 326424012275 ADP-ribose binding site [chemical binding]; other site 326424012276 nudix motif; other site 326424012277 metal binding site [ion binding]; metal-binding site 326424012278 CTP synthetase; Validated; Region: pyrG; PRK05380 326424012279 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 326424012280 Catalytic site [active] 326424012281 active site 326424012282 UTP binding site [chemical binding]; other site 326424012283 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 326424012284 active site 326424012285 putative oxyanion hole; other site 326424012286 catalytic triad [active] 326424012287 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326424012288 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326424012289 active site 326424012290 catalytic tetrad [active] 326424012291 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 326424012292 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424012293 Walker A/P-loop; other site 326424012294 ATP binding site [chemical binding]; other site 326424012295 Q-loop/lid; other site 326424012296 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 326424012297 ABC transporter signature motif; other site 326424012298 Walker B; other site 326424012299 D-loop; other site 326424012300 H-loop/switch region; other site 326424012301 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 326424012302 ATP-NAD kinase; Region: NAD_kinase; pfam01513 326424012303 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 326424012304 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424012305 S-adenosylmethionine binding site [chemical binding]; other site 326424012306 SCP-2 sterol transfer family; Region: SCP2; pfam02036 326424012307 hypothetical protein; Provisional; Region: PRK07236 326424012308 hypothetical protein; Provisional; Region: PRK06847 326424012309 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 326424012310 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 326424012311 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 326424012312 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 326424012313 binding surface 326424012314 TPR motif; other site 326424012315 Tetratricopeptide repeat; Region: TPR_16; pfam13432 326424012316 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 326424012317 Uncharacterized conserved protein [Function unknown]; Region: COG4198 326424012318 Uncharacterized conserved protein [Function unknown]; Region: COG4198 326424012319 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 326424012320 active site 326424012321 DNA binding site [nucleotide binding] 326424012322 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 326424012323 argininosuccinate lyase; Provisional; Region: PRK00855 326424012324 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 326424012325 active sites [active] 326424012326 tetramer interface [polypeptide binding]; other site 326424012327 argininosuccinate synthase; Provisional; Region: PRK13820 326424012328 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 326424012329 ANP binding site [chemical binding]; other site 326424012330 Substrate Binding Site II [chemical binding]; other site 326424012331 Substrate Binding Site I [chemical binding]; other site 326424012332 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 326424012333 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 326424012334 ornithine carbamoyltransferase; Provisional; Region: PRK00779 326424012335 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 326424012336 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 326424012337 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 326424012338 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 326424012339 inhibitor-cofactor binding pocket; inhibition site 326424012340 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326424012341 catalytic residue [active] 326424012342 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 326424012343 feedback inhibition sensing region; other site 326424012344 homohexameric interface [polypeptide binding]; other site 326424012345 nucleotide binding site [chemical binding]; other site 326424012346 N-acetyl-L-glutamate binding site [chemical binding]; other site 326424012347 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 326424012348 heterotetramer interface [polypeptide binding]; other site 326424012349 active site pocket [active] 326424012350 cleavage site 326424012351 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 326424012352 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 326424012353 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 326424012354 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 326424012355 putative tRNA-binding site [nucleotide binding]; other site 326424012356 B3/4 domain; Region: B3_4; pfam03483 326424012357 tRNA synthetase B5 domain; Region: B5; smart00874 326424012358 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 326424012359 dimer interface [polypeptide binding]; other site 326424012360 motif 1; other site 326424012361 motif 3; other site 326424012362 motif 2; other site 326424012363 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 326424012364 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 326424012365 phenylalanyl-tRNA synthetase, alpha subunit; Region: pheS; TIGR00468 326424012366 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 326424012367 dimer interface [polypeptide binding]; other site 326424012368 motif 1; other site 326424012369 active site 326424012370 motif 2; other site 326424012371 motif 3; other site 326424012372 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326424012373 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326424012374 dimer interface [polypeptide binding]; other site 326424012375 phosphorylation site [posttranslational modification] 326424012376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424012377 ATP binding site [chemical binding]; other site 326424012378 Mg2+ binding site [ion binding]; other site 326424012379 G-X-G motif; other site 326424012380 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 326424012381 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 326424012382 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 326424012383 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 326424012384 23S rRNA binding site [nucleotide binding]; other site 326424012385 L21 binding site [polypeptide binding]; other site 326424012386 L13 binding site [polypeptide binding]; other site 326424012387 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 326424012388 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 326424012389 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 326424012390 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 326424012391 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 326424012392 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 326424012393 homopentamer interface [polypeptide binding]; other site 326424012394 active site 326424012395 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 326424012396 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 326424012397 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 326424012398 dimerization interface [polypeptide binding]; other site 326424012399 active site 326424012400 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 326424012401 Lumazine binding domain; Region: Lum_binding; pfam00677 326424012402 Lumazine binding domain; Region: Lum_binding; pfam00677 326424012403 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 326424012404 catalytic motif [active] 326424012405 Zn binding site [ion binding]; other site 326424012406 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 326424012407 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 326424012408 substrate binding site [chemical binding]; other site 326424012409 hexamer interface [polypeptide binding]; other site 326424012410 metal binding site [ion binding]; metal-binding site 326424012411 NusB family; Region: NusB; pfam01029 326424012412 16S rRNA methyltransferase B; Provisional; Region: PRK14901 326424012413 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 326424012414 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 326424012415 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 326424012416 putative active site [active] 326424012417 substrate binding site [chemical binding]; other site 326424012418 putative cosubstrate binding site; other site 326424012419 catalytic site [active] 326424012420 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 326424012421 substrate binding site [chemical binding]; other site 326424012422 primosome assembly protein PriA; Provisional; Region: PRK14873 326424012423 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 326424012424 S-adenosylmethionine synthetase; Validated; Region: PRK05250 326424012425 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 326424012426 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 326424012427 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 326424012428 Flavoprotein; Region: Flavoprotein; pfam02441 326424012429 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 326424012430 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 326424012431 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 326424012432 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 326424012433 catalytic site [active] 326424012434 G-X2-G-X-G-K; other site 326424012435 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 326424012436 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 326424012437 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 326424012438 phosphate binding site [ion binding]; other site 326424012439 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 326424012440 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 326424012441 ATP-grasp domain; Region: ATP-grasp_4; cl17255 326424012442 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 326424012443 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 326424012444 ATP-grasp domain; Region: ATP-grasp_4; cl17255 326424012445 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 326424012446 IMP binding site; other site 326424012447 dimer interface [polypeptide binding]; other site 326424012448 interdomain contacts; other site 326424012449 partial ornithine binding site; other site 326424012450 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 326424012451 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 326424012452 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 326424012453 catalytic site [active] 326424012454 subunit interface [polypeptide binding]; other site 326424012455 dihydroorotase; Validated; Region: pyrC; PRK09357 326424012456 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 326424012457 active site 326424012458 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 326424012459 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 326424012460 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 326424012461 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326424012462 active site 326424012463 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326424012464 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424012465 non-specific DNA binding site [nucleotide binding]; other site 326424012466 salt bridge; other site 326424012467 sequence-specific DNA binding site [nucleotide binding]; other site 326424012468 transcription antitermination factor NusB; Region: nusB; TIGR01951 326424012469 elongation factor P; Validated; Region: PRK00529 326424012470 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 326424012471 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 326424012472 RNA binding site [nucleotide binding]; other site 326424012473 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 326424012474 RNA binding site [nucleotide binding]; other site 326424012475 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 326424012476 dimer interface [polypeptide binding]; other site 326424012477 active site 326424012478 metal binding site [ion binding]; metal-binding site 326424012479 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 326424012480 shikimate kinase; Reviewed; Region: aroK; PRK00131 326424012481 active site 326424012482 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 326424012483 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 326424012484 Tetramer interface [polypeptide binding]; other site 326424012485 active site 326424012486 FMN-binding site [chemical binding]; other site 326424012487 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 326424012488 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 326424012489 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 326424012490 NAD(P) binding site [chemical binding]; other site 326424012491 shikimate binding site; other site 326424012492 YceG-like family; Region: YceG; pfam02618 326424012493 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 326424012494 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 326424012495 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 326424012496 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 326424012497 motif 1; other site 326424012498 active site 326424012499 motif 2; other site 326424012500 motif 3; other site 326424012501 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 326424012502 DHHA1 domain; Region: DHHA1; pfam02272 326424012503 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 326424012504 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326424012505 Walker A motif; other site 326424012506 ATP binding site [chemical binding]; other site 326424012507 Walker B motif; other site 326424012508 recombination factor protein RarA; Reviewed; Region: PRK13342 326424012509 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 326424012510 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 326424012511 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 326424012512 Transcriptional regulators [Transcription]; Region: FadR; COG2186 326424012513 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326424012514 DNA-binding site [nucleotide binding]; DNA binding site 326424012515 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 326424012516 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 326424012517 active site 326424012518 HIGH motif; other site 326424012519 nucleotide binding site [chemical binding]; other site 326424012520 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 326424012521 active site 326424012522 KMSKS motif; other site 326424012523 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 326424012524 Predicted transcriptional regulators [Transcription]; Region: COG1733 326424012525 Right handed beta helix region; Region: Beta_helix; pfam13229 326424012526 Right handed beta helix region; Region: Beta_helix; pfam13229 326424012527 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 326424012528 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326424012529 Walker A motif; other site 326424012530 ATP binding site [chemical binding]; other site 326424012531 Walker B motif; other site 326424012532 arginine finger; other site 326424012533 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 326424012534 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 326424012535 intersubunit interface [polypeptide binding]; other site 326424012536 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 326424012537 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 326424012538 putative active site [active] 326424012539 putative substrate binding site [chemical binding]; other site 326424012540 ATP binding site [chemical binding]; other site 326424012541 Phosphotransferase enzyme family; Region: APH; pfam01636 326424012542 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 326424012543 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424012544 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424012545 acyl-activating enzyme (AAE) consensus motif; other site 326424012546 AMP binding site [chemical binding]; other site 326424012547 active site 326424012548 CoA binding site [chemical binding]; other site 326424012549 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 326424012550 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 326424012551 NAD binding site [chemical binding]; other site 326424012552 catalytic residues [active] 326424012553 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 326424012554 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 326424012555 NAD binding site [chemical binding]; other site 326424012556 catalytic Zn binding site [ion binding]; other site 326424012557 substrate binding site [chemical binding]; other site 326424012558 structural Zn binding site [ion binding]; other site 326424012559 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 326424012560 Cytochrome P450; Region: p450; cl12078 326424012561 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 326424012562 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424012563 substrate binding site [chemical binding]; other site 326424012564 oxyanion hole (OAH) forming residues; other site 326424012565 trimer interface [polypeptide binding]; other site 326424012566 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424012567 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 326424012568 acyl-activating enzyme (AAE) consensus motif; other site 326424012569 AMP binding site [chemical binding]; other site 326424012570 active site 326424012571 CoA binding site [chemical binding]; other site 326424012572 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 326424012573 CoA binding domain; Region: CoA_binding; cl17356 326424012574 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 326424012575 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 326424012576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 326424012577 NIPSNAP; Region: NIPSNAP; pfam07978 326424012578 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 326424012579 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326424012580 Zn binding site [ion binding]; other site 326424012581 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326424012582 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326424012583 DNA binding site [nucleotide binding] 326424012584 GAF domain; Region: GAF; pfam01590 326424012585 GAF domain; Region: GAF_2; pfam13185 326424012586 Amidohydrolase; Region: Amidohydro_2; pfam04909 326424012587 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 326424012588 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326424012589 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 326424012590 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 326424012591 PAS domain; Region: PAS_9; pfam13426 326424012592 putative active site [active] 326424012593 heme pocket [chemical binding]; other site 326424012594 PAS domain S-box; Region: sensory_box; TIGR00229 326424012595 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 326424012596 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 326424012597 metal binding site [ion binding]; metal-binding site 326424012598 active site 326424012599 I-site; other site 326424012600 Radical SAM superfamily; Region: Radical_SAM; pfam04055 326424012601 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 326424012602 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 326424012603 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326424012604 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 326424012605 active site 326424012606 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 326424012607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424012608 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424012609 active site 326424012610 phosphorylation site [posttranslational modification] 326424012611 intermolecular recognition site; other site 326424012612 dimerization interface [polypeptide binding]; other site 326424012613 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 326424012614 classical (c) SDRs; Region: SDR_c; cd05233 326424012615 NAD(P) binding site [chemical binding]; other site 326424012616 active site 326424012617 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 326424012618 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 326424012619 Walker A/P-loop; other site 326424012620 ATP binding site [chemical binding]; other site 326424012621 Q-loop/lid; other site 326424012622 ABC transporter signature motif; other site 326424012623 Walker B; other site 326424012624 D-loop; other site 326424012625 H-loop/switch region; other site 326424012626 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 326424012627 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424012628 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424012629 active site 326424012630 ATP binding site [chemical binding]; other site 326424012631 substrate binding site [chemical binding]; other site 326424012632 activation loop (A-loop); other site 326424012633 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 326424012634 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 326424012635 putative sugar binding sites [chemical binding]; other site 326424012636 Q-X-W motif; other site 326424012637 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326424012638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424012639 active site 326424012640 phosphorylation site [posttranslational modification] 326424012641 intermolecular recognition site; other site 326424012642 dimerization interface [polypeptide binding]; other site 326424012643 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326424012644 DNA binding site [nucleotide binding] 326424012645 K+-transporting ATPase, c chain; Region: KdpC; cl00944 326424012646 K+-transporting ATPase, c chain; Region: KdpC; cl00944 326424012647 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 326424012648 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 326424012649 Soluble P-type ATPase [General function prediction only]; Region: COG4087 326424012650 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 326424012651 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 326424012652 similar to hypothetical protein; Evidence 6 : Doubtful CDS 326424012653 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 326424012654 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 326424012655 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 326424012656 Ligand Binding Site [chemical binding]; other site 326424012657 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 326424012658 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326424012659 dimer interface [polypeptide binding]; other site 326424012660 phosphorylation site [posttranslational modification] 326424012661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424012662 ATP binding site [chemical binding]; other site 326424012663 Mg2+ binding site [ion binding]; other site 326424012664 G-X-G motif; other site 326424012665 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424012666 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 326424012667 NAD(P) binding site [chemical binding]; other site 326424012668 active site 326424012669 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 326424012670 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424012671 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424012672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424012673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424012674 TIR domain; Region: TIR_2; pfam13676 326424012675 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326424012676 AAA domain; Region: AAA_22; pfam13401 326424012677 Walker A motif; other site 326424012678 ATP binding site [chemical binding]; other site 326424012679 Walker B motif; other site 326424012680 TIR domain; Region: TIR_2; pfam13676 326424012681 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 326424012682 FMN binding site [chemical binding]; other site 326424012683 dimer interface [polypeptide binding]; other site 326424012684 Predicted transcriptional regulators [Transcription]; Region: COG1733 326424012685 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 326424012686 H+ Antiporter protein; Region: 2A0121; TIGR00900 326424012687 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 326424012688 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326424012689 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 326424012690 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 326424012691 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 326424012692 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 326424012693 Phosphoglycerate mutase family; Region: PGAM; smart00855 326424012694 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 326424012695 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 326424012696 active site 326424012697 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 326424012698 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 326424012699 molybdopterin cofactor binding site; other site 326424012700 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 326424012701 molybdopterin cofactor binding site; other site 326424012702 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 326424012703 Flavodoxin; Region: Flavodoxin_1; pfam00258 326424012704 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 326424012705 FAD binding pocket [chemical binding]; other site 326424012706 conserved FAD binding motif [chemical binding]; other site 326424012707 phosphate binding motif [ion binding]; other site 326424012708 beta-alpha-beta structure motif; other site 326424012709 NAD binding pocket [chemical binding]; other site 326424012710 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 326424012711 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 326424012712 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 326424012713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424012714 putative substrate translocation pore; other site 326424012715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424012716 putative substrate translocation pore; other site 326424012717 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 326424012718 MarR family; Region: MarR_2; cl17246 326424012719 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 326424012720 Phosphotransferase enzyme family; Region: APH; pfam01636 326424012721 putative active site [active] 326424012722 ATP binding site [chemical binding]; other site 326424012723 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 326424012724 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 326424012725 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 326424012726 PAS fold; Region: PAS_2; pfam08446 326424012727 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 326424012728 GAF domain; Region: GAF; pfam01590 326424012729 Phytochrome region; Region: PHY; pfam00360 326424012730 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 326424012731 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 326424012732 heme binding pocket [chemical binding]; other site 326424012733 heme ligand [chemical binding]; other site 326424012734 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 326424012735 intracellular protease, PfpI family; Region: PfpI; TIGR01382 326424012736 proposed catalytic triad [active] 326424012737 conserved cys residue [active] 326424012738 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 326424012739 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 326424012740 [2Fe-2S] cluster binding site [ion binding]; other site 326424012741 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 326424012742 putative alpha subunit interface [polypeptide binding]; other site 326424012743 putative active site [active] 326424012744 putative substrate binding site [chemical binding]; other site 326424012745 Fe binding site [ion binding]; other site 326424012746 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 326424012747 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 326424012748 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 326424012749 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 326424012750 Amidohydrolase; Region: Amidohydro_2; pfam04909 326424012751 short chain dehydrogenase; Provisional; Region: PRK07791 326424012752 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424012753 NAD(P) binding site [chemical binding]; other site 326424012754 active site 326424012755 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 326424012756 Part of AAA domain; Region: AAA_19; pfam13245 326424012757 Family description; Region: UvrD_C_2; pfam13538 326424012758 Putative esterase; Region: Esterase; pfam00756 326424012759 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 326424012760 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 326424012761 DNA-binding site [nucleotide binding]; DNA binding site 326424012762 RNA-binding motif; other site 326424012763 Helix-turn-helix domain; Region: HTH_17; pfam12728 326424012764 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 326424012765 GAF domain; Region: GAF; pfam01590 326424012766 GAF domain; Region: GAF_2; pfam13185 326424012767 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 326424012768 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 326424012769 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 326424012770 putative active site pocket [active] 326424012771 cleavage site 326424012772 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 326424012773 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 326424012774 active site residue [active] 326424012775 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 326424012776 active site residue [active] 326424012777 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 326424012778 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 326424012779 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 326424012780 conserved cys residue [active] 326424012781 FOG: WD40 repeat [General function prediction only]; Region: COG2319 326424012782 WD domain, G-beta repeat; Region: WD40; pfam00400 326424012783 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 326424012784 active site 326424012785 putative catalytic site [active] 326424012786 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 326424012787 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 326424012788 EthD domain; Region: EthD; cl17553 326424012789 Nuclease-related domain; Region: NERD; pfam08378 326424012790 Putative esterase; Region: Esterase; pfam00756 326424012791 S-formylglutathione hydrolase; Region: PLN02442 326424012792 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 326424012793 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424012794 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424012795 short chain dehydrogenase; Provisional; Region: PRK06180 326424012796 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424012797 NAD(P) binding site [chemical binding]; other site 326424012798 active site 326424012799 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424012800 salt bridge; other site 326424012801 non-specific DNA binding site [nucleotide binding]; other site 326424012802 sequence-specific DNA binding site [nucleotide binding]; other site 326424012803 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 326424012804 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 326424012805 FtsX-like permease family; Region: FtsX; pfam02687 326424012806 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 326424012807 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 326424012808 Walker A/P-loop; other site 326424012809 ATP binding site [chemical binding]; other site 326424012810 Q-loop/lid; other site 326424012811 ABC transporter signature motif; other site 326424012812 Walker B; other site 326424012813 D-loop; other site 326424012814 H-loop/switch region; other site 326424012815 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 326424012816 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 326424012817 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 326424012818 DNA binding residues [nucleotide binding] 326424012819 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 326424012820 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 326424012821 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 326424012822 hypothetical protein; Provisional; Region: PRK06126 326424012823 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 326424012824 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 326424012825 active site 326424012826 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 326424012827 non-prolyl cis peptide bond; other site 326424012828 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326424012829 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 326424012830 Walker A/P-loop; other site 326424012831 ATP binding site [chemical binding]; other site 326424012832 Q-loop/lid; other site 326424012833 ABC transporter signature motif; other site 326424012834 Walker B; other site 326424012835 D-loop; other site 326424012836 H-loop/switch region; other site 326424012837 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 326424012838 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326424012839 Walker A/P-loop; other site 326424012840 ATP binding site [chemical binding]; other site 326424012841 Q-loop/lid; other site 326424012842 ABC transporter signature motif; other site 326424012843 Walker B; other site 326424012844 D-loop; other site 326424012845 H-loop/switch region; other site 326424012846 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 326424012847 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 326424012848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424012849 dimer interface [polypeptide binding]; other site 326424012850 conserved gate region; other site 326424012851 putative PBP binding loops; other site 326424012852 ABC-ATPase subunit interface; other site 326424012853 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 326424012854 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424012855 dimer interface [polypeptide binding]; other site 326424012856 conserved gate region; other site 326424012857 putative PBP binding loops; other site 326424012858 ABC-ATPase subunit interface; other site 326424012859 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_9; cd08496 326424012860 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 326424012861 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 326424012862 CGNR zinc finger; Region: zf-CGNR; pfam11706 326424012863 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 326424012864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 326424012865 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 326424012866 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 326424012867 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 326424012868 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424012869 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 326424012870 dimerization interface [polypeptide binding]; other site 326424012871 DNA binding residues [nucleotide binding] 326424012872 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 326424012873 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 326424012874 homodimer interface [polypeptide binding]; other site 326424012875 active site 326424012876 TDP-binding site; other site 326424012877 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 326424012878 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 326424012879 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 326424012880 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 326424012881 Methyltransferase domain; Region: Methyltransf_23; pfam13489 326424012882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424012883 S-adenosylmethionine binding site [chemical binding]; other site 326424012884 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 326424012885 catalytic core [active] 326424012886 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 326424012887 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 326424012888 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 326424012889 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 326424012890 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 326424012891 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 326424012892 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 326424012893 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 326424012894 putative active site [active] 326424012895 putative dimer interface [polypeptide binding]; other site 326424012896 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 326424012897 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 326424012898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424012899 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 326424012900 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 326424012901 Short C-terminal domain; Region: SHOCT; pfam09851 326424012902 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 326424012903 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 326424012904 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 326424012905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 326424012906 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 326424012907 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 326424012908 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 326424012909 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 326424012910 Methyltransferase domain; Region: Methyltransf_26; pfam13659 326424012911 Putative phage integrase; Region: Phage_Integr_2; pfam13009 326424012912 Winged helix-turn helix; Region: HTH_29; pfam13551 326424012913 Homeodomain-like domain; Region: HTH_32; pfam13565 326424012914 DDE superfamily endonuclease; Region: DDE_3; pfam13358 326424012915 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 326424012916 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326424012917 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 326424012918 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 326424012919 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 326424012920 active site 326424012921 DNA binding site [nucleotide binding] 326424012922 Int/Topo IB signature motif; other site 326424012923 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 326424012924 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 326424012925 Magnesium ion binding site [ion binding]; other site 326424012926 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326424012927 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424012928 non-specific DNA binding site [nucleotide binding]; other site 326424012929 salt bridge; other site 326424012930 sequence-specific DNA binding site [nucleotide binding]; other site 326424012931 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 326424012932 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 326424012933 non-specific DNA binding site [nucleotide binding]; other site 326424012934 salt bridge; other site 326424012935 sequence-specific DNA binding site [nucleotide binding]; other site 326424012936 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 326424012937 Helix-turn-helix domain; Region: HTH_17; pfam12728 326424012938 Helix-turn-helix domain; Region: HTH_17; cl17695 326424012939 Frankia-40 domain; Region: Frankia_40_dom; TIGR03917 326424012940 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 326424012941 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 326424012942 Int/Topo IB signature motif; other site 326424012943 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 326424012944 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424012945 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424012946 Epoxide hydrolase N terminus; Region: EHN; pfam06441 326424012947 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 326424012948 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424012949 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424012950 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 326424012951 pantoate--beta-alanine ligase; Region: panC; TIGR00018 326424012952 active site 326424012953 nucleotide binding site [chemical binding]; other site 326424012954 HIGH motif; other site 326424012955 KMSKS motif; other site 326424012956 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 326424012957 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 326424012958 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 326424012959 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 326424012960 putative ligand binding site [chemical binding]; other site 326424012961 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 326424012962 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 326424012963 NAD binding site [chemical binding]; other site 326424012964 catalytic Zn binding site [ion binding]; other site 326424012965 substrate binding site [chemical binding]; other site 326424012966 structural Zn binding site [ion binding]; other site 326424012967 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 326424012968 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424012969 NAD(P) binding site [chemical binding]; other site 326424012970 active site 326424012971 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424012972 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 326424012973 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 326424012974 putative FMN binding site [chemical binding]; other site 326424012975 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 326424012976 active site 326424012977 putative catalytic site [active] 326424012978 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 326424012979 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 326424012980 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 326424012981 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 326424012982 sequence-specific DNA binding site [nucleotide binding]; other site 326424012983 salt bridge; other site 326424012984 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 326424012985 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424012986 Transcriptional regulator [Transcription]; Region: IclR; COG1414 326424012987 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 326424012988 Bacterial transcriptional regulator; Region: IclR; pfam01614 326424012989 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 326424012990 FAD binding domain; Region: FAD_binding_4; pfam01565 326424012991 malate synthase G; Provisional; Region: PRK02999 326424012992 active site 326424012993 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 326424012994 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 326424012995 dimer interface [polypeptide binding]; other site 326424012996 active site 326424012997 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 326424012998 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424012999 substrate binding site [chemical binding]; other site 326424013000 oxyanion hole (OAH) forming residues; other site 326424013001 trimer interface [polypeptide binding]; other site 326424013002 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 326424013003 Probable transposase; Region: OrfB_IS605; pfam01385 326424013004 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 326424013005 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 326424013006 Walker A/P-loop; other site 326424013007 ATP binding site [chemical binding]; other site 326424013008 Q-loop/lid; other site 326424013009 ABC transporter signature motif; other site 326424013010 Walker B; other site 326424013011 D-loop; other site 326424013012 H-loop/switch region; other site 326424013013 Predicted transcriptional regulators [Transcription]; Region: COG1725 326424013014 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326424013015 DNA-binding site [nucleotide binding]; DNA binding site 326424013016 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424013017 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 326424013018 Cytochrome P450; Region: p450; cl12078 326424013019 SnoaL-like domain; Region: SnoaL_2; pfam12680 326424013020 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 326424013021 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 326424013022 catalytic residues [active] 326424013023 Phosphotransferase enzyme family; Region: APH; pfam01636 326424013024 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 326424013025 active site 326424013026 ATP binding site [chemical binding]; other site 326424013027 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 326424013028 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 326424013029 catalytic residues [active] 326424013030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424013031 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326424013032 TIR domain; Region: TIR_2; pfam13676 326424013033 FOG: WD40 repeat [General function prediction only]; Region: COG2319 326424013034 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 326424013035 structural tetrad; other site 326424013036 Domain of unknown function (DUF397); Region: DUF397; pfam04149 326424013037 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424013038 sequence-specific DNA binding site [nucleotide binding]; other site 326424013039 salt bridge; other site 326424013040 Flavoprotein; Region: Flavoprotein; pfam02441 326424013041 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 326424013042 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424013043 active site 326424013044 ATP binding site [chemical binding]; other site 326424013045 substrate binding site [chemical binding]; other site 326424013046 activation loop (A-loop); other site 326424013047 TIR domain; Region: TIR_2; pfam13676 326424013048 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 326424013049 putative active site [active] 326424013050 Domain of unknown function DUF87; Region: DUF87; pfam01935 326424013051 AAA-like domain; Region: AAA_10; pfam12846 326424013052 Zonular occludens toxin (Zot); Region: Zot; cl17485 326424013053 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 326424013054 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 326424013055 Magnesium ion binding site [ion binding]; other site 326424013056 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 326424013057 nudix motif; other site 326424013058 SdiA-regulated; Region: SdiA-regulated; cd09971 326424013059 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 326424013060 putative active site [active] 326424013061 putative acetyltransferase; Provisional; Region: PRK03624 326424013062 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326424013063 Coenzyme A binding pocket [chemical binding]; other site 326424013064 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326424013065 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 326424013066 Walker A motif; other site 326424013067 ATP binding site [chemical binding]; other site 326424013068 Walker B motif; other site 326424013069 arginine finger; other site 326424013070 Flavoprotein; Region: Flavoprotein; pfam02441 326424013071 Putative sensor; Region: Sensor; pfam13796 326424013072 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 326424013073 Histidine kinase; Region: HisKA_3; pfam07730 326424013074 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424013075 NAD(P) binding site [chemical binding]; other site 326424013076 active site 326424013077 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424013078 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424013079 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 326424013080 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 326424013081 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 326424013082 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 326424013083 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 326424013084 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424013085 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 326424013086 acyl-activating enzyme (AAE) consensus motif; other site 326424013087 acyl-activating enzyme (AAE) consensus motif; other site 326424013088 putative AMP binding site [chemical binding]; other site 326424013089 putative active site [active] 326424013090 putative CoA binding site [chemical binding]; other site 326424013091 CoA binding site [chemical binding]; other site 326424013092 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326424013093 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326424013094 active site 326424013095 catalytic tetrad [active] 326424013096 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424013097 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 326424013098 Walker A/P-loop; other site 326424013099 ATP binding site [chemical binding]; other site 326424013100 Q-loop/lid; other site 326424013101 ABC transporter signature motif; other site 326424013102 Walker B; other site 326424013103 D-loop; other site 326424013104 H-loop/switch region; other site 326424013105 Protein of unknown function (DUF664); Region: DUF664; pfam04978 326424013106 DinB superfamily; Region: DinB_2; pfam12867 326424013107 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 326424013108 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 326424013109 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 326424013110 Mechanosensitive ion channel; Region: MS_channel; pfam00924 326424013111 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 326424013112 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 326424013113 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 326424013114 Ligand Binding Site [chemical binding]; other site 326424013115 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424013116 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424013117 active site 326424013118 ATP binding site [chemical binding]; other site 326424013119 substrate binding site [chemical binding]; other site 326424013120 activation loop (A-loop); other site 326424013121 FOG: WD40 repeat [General function prediction only]; Region: COG2319 326424013122 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 326424013123 structural tetrad; other site 326424013124 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 326424013125 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 326424013126 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 326424013127 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 326424013128 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424013129 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 326424013130 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424013131 substrate binding site [chemical binding]; other site 326424013132 oxyanion hole (OAH) forming residues; other site 326424013133 trimer interface [polypeptide binding]; other site 326424013134 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 326424013135 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 326424013136 metal binding site [ion binding]; metal-binding site 326424013137 active site 326424013138 I-site; other site 326424013139 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 326424013140 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 326424013141 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326424013142 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326424013143 homodimer interface [polypeptide binding]; other site 326424013144 catalytic residue [active] 326424013145 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 326424013146 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 326424013147 putative ligand binding site [chemical binding]; other site 326424013148 TIGR03086 family protein; Region: TIGR03086 326424013149 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 326424013150 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 326424013151 HTH domain; Region: HTH_11; pfam08279 326424013152 WYL domain; Region: WYL; pfam13280 326424013153 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 326424013154 putative deacylase active site [active] 326424013155 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 326424013156 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424013157 NAD(P) binding site [chemical binding]; other site 326424013158 active site 326424013159 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 326424013160 active site 326424013161 ATP binding site [chemical binding]; other site 326424013162 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 326424013163 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 326424013164 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 326424013165 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; pfam05985 326424013166 TIR domain; Region: TIR_2; pfam13676 326424013167 NACHT domain; Region: NACHT; pfam05729 326424013168 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 326424013169 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 326424013170 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 326424013171 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 326424013172 structural tetrad; other site 326424013173 FOG: WD40 repeat [General function prediction only]; Region: COG2319 326424013174 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 326424013175 structural tetrad; other site 326424013176 FOG: WD40 repeat [General function prediction only]; Region: COG2319 326424013177 WD40 repeats; Region: WD40; smart00320 326424013178 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 326424013179 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 326424013180 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 326424013181 AAA domain; Region: AAA_33; pfam13671 326424013182 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 326424013183 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 326424013184 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 326424013185 WYL domain; Region: WYL; pfam13280 326424013186 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 326424013187 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 326424013188 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693 326424013189 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 326424013190 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 326424013191 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 326424013192 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 326424013193 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 326424013194 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 326424013195 Transcriptional regulator [Transcription]; Region: IclR; COG1414 326424013196 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 326424013197 Bacterial transcriptional regulator; Region: IclR; pfam01614 326424013198 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 326424013199 FMN binding site [chemical binding]; other site 326424013200 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 326424013201 PemK-like protein; Region: PemK; cl00995 326424013202 similar to hypothetical protein; Evidence 4 : Homologs of previously reported genes of unknown function 326424013203 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 326424013204 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326424013205 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326424013206 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 326424013207 putative substrate binding pocket [chemical binding]; other site 326424013208 putative dimerization interface [polypeptide binding]; other site 326424013209 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 326424013210 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 326424013211 FAD binding pocket [chemical binding]; other site 326424013212 FAD binding motif [chemical binding]; other site 326424013213 phosphate binding motif [ion binding]; other site 326424013214 NAD binding pocket [chemical binding]; other site 326424013215 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 326424013216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 326424013217 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424013218 short chain dehydrogenase; Provisional; Region: PRK06123 326424013219 NAD(P) binding site [chemical binding]; other site 326424013220 active site 326424013221 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 326424013222 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 326424013223 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 326424013224 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 326424013225 conserved cys residue [active] 326424013226 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 326424013227 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 326424013228 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 326424013229 nudix motif; other site 326424013230 tellurite resistance protein terB; Region: terB; cd07176 326424013231 putative metal binding site [ion binding]; other site 326424013232 SCP-2 sterol transfer family; Region: SCP2; pfam02036 326424013233 hypothetical protein; Provisional; Region: PRK09266 326424013234 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 326424013235 homodimer interface [polypeptide binding]; other site 326424013236 substrate-cofactor binding pocket; other site 326424013237 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326424013238 catalytic residue [active] 326424013239 cyclase homology domain; Region: CHD; cd07302 326424013240 metal binding site [ion binding]; metal-binding site 326424013241 malate dehydrogenase; Provisional; Region: PRK05442 326424013242 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 326424013243 NAD(P) binding site [chemical binding]; other site 326424013244 dimer interface [polypeptide binding]; other site 326424013245 malate binding site [chemical binding]; other site 326424013246 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 326424013247 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 326424013248 putative ligand binding site [chemical binding]; other site 326424013249 Rdx family; Region: Rdx; cl01407 326424013250 Domain of unknown function (DUF336); Region: DUF336; cl01249 326424013251 Domain of unknown function (DUF397); Region: DUF397; pfam04149 326424013252 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424013253 non-specific DNA binding site [nucleotide binding]; other site 326424013254 salt bridge; other site 326424013255 sequence-specific DNA binding site [nucleotide binding]; other site 326424013256 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 326424013257 ATP binding site [chemical binding]; other site 326424013258 G-X-G motif; other site 326424013259 DEAD-like helicases superfamily; Region: DEXDc; smart00487 326424013260 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326424013261 ATP binding site [chemical binding]; other site 326424013262 putative Mg++ binding site [ion binding]; other site 326424013263 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326424013264 nucleotide binding region [chemical binding]; other site 326424013265 ATP-binding site [chemical binding]; other site 326424013266 Helicase associated domain (HA2); Region: HA2; pfam04408 326424013267 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 326424013268 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 326424013269 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 326424013270 galactokinase; Provisional; Region: PRK05101 326424013271 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 326424013272 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 326424013273 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 326424013274 dimer interface [polypeptide binding]; other site 326424013275 active site 326424013276 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 326424013277 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 326424013278 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 326424013279 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 326424013280 DNA binding residues [nucleotide binding] 326424013281 dimer interface [polypeptide binding]; other site 326424013282 [2Fe-2S] cluster binding site [ion binding]; other site 326424013283 Predicted flavoprotein [General function prediction only]; Region: COG0431 326424013284 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 326424013285 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 326424013286 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 326424013287 putative ligand binding site [chemical binding]; other site 326424013288 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 326424013289 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 326424013290 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 326424013291 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 326424013292 Walker A/P-loop; other site 326424013293 ATP binding site [chemical binding]; other site 326424013294 Q-loop/lid; other site 326424013295 ABC transporter signature motif; other site 326424013296 Walker B; other site 326424013297 D-loop; other site 326424013298 H-loop/switch region; other site 326424013299 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 326424013300 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 326424013301 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 326424013302 CHAT domain; Region: CHAT; cl17868 326424013303 AAA domain; Region: AAA_22; pfam13401 326424013304 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424013305 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 326424013306 binding surface 326424013307 TPR motif; other site 326424013308 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424013309 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 326424013310 binding surface 326424013311 TPR motif; other site 326424013312 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424013313 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424013314 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 326424013315 binding surface 326424013316 TPR motif; other site 326424013317 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424013318 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424013319 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 326424013320 binding surface 326424013321 TPR motif; other site 326424013322 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424013323 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 326424013324 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 326424013325 active site 326424013326 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 326424013327 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 326424013328 active site 326424013329 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 326424013330 dimer interface [polypeptide binding]; other site 326424013331 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 326424013332 Ligand Binding Site [chemical binding]; other site 326424013333 Molecular Tunnel; other site 326424013334 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 326424013335 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 326424013336 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424013337 Walker A/P-loop; other site 326424013338 ATP binding site [chemical binding]; other site 326424013339 Q-loop/lid; other site 326424013340 ABC transporter signature motif; other site 326424013341 Walker B; other site 326424013342 D-loop; other site 326424013343 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 326424013344 dimer interface [polypeptide binding]; other site 326424013345 putative PBP binding regions; other site 326424013346 ABC-ATPase subunit interface; other site 326424013347 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 326424013348 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 326424013349 intersubunit interface [polypeptide binding]; other site 326424013350 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 326424013351 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 326424013352 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326424013353 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 326424013354 dimerization interface [polypeptide binding]; other site 326424013355 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 326424013356 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 326424013357 putative Iron-sulfur protein interface [polypeptide binding]; other site 326424013358 proximal heme binding site [chemical binding]; other site 326424013359 distal heme binding site [chemical binding]; other site 326424013360 putative dimer interface [polypeptide binding]; other site 326424013361 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 326424013362 L-aspartate oxidase; Provisional; Region: PRK06175 326424013363 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 326424013364 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 326424013365 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 326424013366 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 326424013367 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 326424013368 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 326424013369 hydroxyglutarate oxidase; Provisional; Region: PRK11728 326424013370 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 326424013371 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 326424013372 Chain length determinant protein; Region: Wzz; cl15801 326424013373 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 326424013374 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 326424013375 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 326424013376 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 326424013377 NAD(P) binding site [chemical binding]; other site 326424013378 homodimer interface [polypeptide binding]; other site 326424013379 substrate binding site [chemical binding]; other site 326424013380 active site 326424013381 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424013382 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 326424013383 NAD(P) binding site [chemical binding]; other site 326424013384 active site 326424013385 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 326424013386 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 326424013387 putative trimer interface [polypeptide binding]; other site 326424013388 putative CoA binding site [chemical binding]; other site 326424013389 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 326424013390 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 326424013391 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 326424013392 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 326424013393 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 326424013394 N-acetyl-D-glucosamine binding site [chemical binding]; other site 326424013395 catalytic residue [active] 326424013396 S4 domain; Region: S4_2; pfam13275 326424013397 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 326424013398 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 326424013399 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 326424013400 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 326424013401 dimer interface [polypeptide binding]; other site 326424013402 active site 326424013403 CoA binding pocket [chemical binding]; other site 326424013404 acyl carrier protein; Provisional; Region: acpP; PRK00982 326424013405 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 326424013406 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 326424013407 dimer interface [polypeptide binding]; other site 326424013408 active site 326424013409 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 326424013410 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 326424013411 H+ Antiporter protein; Region: 2A0121; TIGR00900 326424013412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424013413 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326424013414 Walker A motif; other site 326424013415 ATP binding site [chemical binding]; other site 326424013416 Walker B motif; other site 326424013417 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 326424013418 Peptidase family M41; Region: Peptidase_M41; pfam01434 326424013419 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 326424013420 active site 326424013421 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 326424013422 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326424013423 FeS/SAM binding site; other site 326424013424 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 326424013425 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 326424013426 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 326424013427 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 326424013428 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 326424013429 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 326424013430 proline aminopeptidase P II; Provisional; Region: PRK10879 326424013431 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 326424013432 active site 326424013433 Lsr2; Region: Lsr2; pfam11774 326424013434 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 326424013435 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424013436 Walker A/P-loop; other site 326424013437 ATP binding site [chemical binding]; other site 326424013438 Q-loop/lid; other site 326424013439 ABC transporter signature motif; other site 326424013440 Walker B; other site 326424013441 D-loop; other site 326424013442 H-loop/switch region; other site 326424013443 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 326424013444 PAS fold; Region: PAS_4; pfam08448 326424013445 putative active site [active] 326424013446 heme pocket [chemical binding]; other site 326424013447 PAS fold; Region: PAS_3; pfam08447 326424013448 GAF domain; Region: GAF; cl17456 326424013449 GAF domain; Region: GAF_2; pfam13185 326424013450 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 326424013451 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 326424013452 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 326424013453 ATP binding site [chemical binding]; other site 326424013454 Mg2+ binding site [ion binding]; other site 326424013455 G-X-G motif; other site 326424013456 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 326424013457 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326424013458 Coenzyme A binding pocket [chemical binding]; other site 326424013459 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 326424013460 CoA binding domain; Region: CoA_binding_2; pfam13380 326424013461 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 326424013462 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 326424013463 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 326424013464 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 326424013465 active site 326424013466 Zn binding site [ion binding]; other site 326424013467 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 326424013468 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424013469 acyl-activating enzyme (AAE) consensus motif; other site 326424013470 AMP binding site [chemical binding]; other site 326424013471 active site 326424013472 CoA binding site [chemical binding]; other site 326424013473 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 326424013474 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 326424013475 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326424013476 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 326424013477 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 326424013478 DNA binding residues [nucleotide binding] 326424013479 Trehalase; Region: Trehalase; cl17346 326424013480 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 326424013481 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 326424013482 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 326424013483 active site 326424013484 dimer interface [polypeptide binding]; other site 326424013485 effector binding site; other site 326424013486 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 326424013487 TSCPD domain; Region: TSCPD; pfam12637 326424013488 ATP cone domain; Region: ATP-cone; pfam03477 326424013489 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 326424013490 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 326424013491 LexA repressor; Validated; Region: PRK00215 326424013492 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 326424013493 Catalytic site [active] 326424013494 GTPases [General function prediction only]; Region: HflX; COG2262 326424013495 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 326424013496 HflX GTPase family; Region: HflX; cd01878 326424013497 G1 box; other site 326424013498 GTP/Mg2+ binding site [chemical binding]; other site 326424013499 Switch I region; other site 326424013500 G2 box; other site 326424013501 G3 box; other site 326424013502 Switch II region; other site 326424013503 G4 box; other site 326424013504 G5 box; other site 326424013505 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 326424013506 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 326424013507 active site 326424013508 metal binding site [ion binding]; metal-binding site 326424013509 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326424013510 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 326424013511 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 326424013512 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 326424013513 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 326424013514 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 326424013515 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 326424013516 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 326424013517 PGAP1-like protein; Region: PGAP1; pfam07819 326424013518 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 326424013519 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 326424013520 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 326424013521 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326424013522 FeS/SAM binding site; other site 326424013523 TRAM domain; Region: TRAM; cl01282 326424013524 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 326424013525 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 326424013526 Walker A/P-loop; other site 326424013527 ATP binding site [chemical binding]; other site 326424013528 Q-loop/lid; other site 326424013529 ABC transporter signature motif; other site 326424013530 Walker B; other site 326424013531 D-loop; other site 326424013532 H-loop/switch region; other site 326424013533 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 326424013534 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 326424013535 substrate binding pocket [chemical binding]; other site 326424013536 membrane-bound complex binding site; other site 326424013537 hinge residues; other site 326424013538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424013539 dimer interface [polypeptide binding]; other site 326424013540 conserved gate region; other site 326424013541 putative PBP binding loops; other site 326424013542 ABC-ATPase subunit interface; other site 326424013543 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 326424013544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424013545 dimer interface [polypeptide binding]; other site 326424013546 conserved gate region; other site 326424013547 putative PBP binding loops; other site 326424013548 ABC-ATPase subunit interface; other site 326424013549 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 326424013550 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 326424013551 Zn2+ binding site [ion binding]; other site 326424013552 Mg2+ binding site [ion binding]; other site 326424013553 RecX family; Region: RecX; pfam02631 326424013554 recombinase A; Provisional; Region: recA; PRK09354 326424013555 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 326424013556 hexamer interface [polypeptide binding]; other site 326424013557 Walker A motif; other site 326424013558 ATP binding site [chemical binding]; other site 326424013559 Walker B motif; other site 326424013560 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 326424013561 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 326424013562 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326424013563 ATP binding site [chemical binding]; other site 326424013564 putative Mg++ binding site [ion binding]; other site 326424013565 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326424013566 nucleotide binding region [chemical binding]; other site 326424013567 ATP-binding site [chemical binding]; other site 326424013568 DEAD/H associated; Region: DEAD_assoc; pfam08494 326424013569 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 326424013570 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 326424013571 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 326424013572 putative DNA binding site [nucleotide binding]; other site 326424013573 catalytic residue [active] 326424013574 putative H2TH interface [polypeptide binding]; other site 326424013575 putative catalytic residues [active] 326424013576 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 326424013577 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 326424013578 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326424013579 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 326424013580 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 326424013581 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 326424013582 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 326424013583 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 326424013584 dimerization interface [polypeptide binding]; other site 326424013585 DPS ferroxidase diiron center [ion binding]; other site 326424013586 ion pore; other site 326424013587 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 326424013588 sequence-specific DNA binding site [nucleotide binding]; other site 326424013589 salt bridge; other site 326424013590 competence damage-inducible protein A; Provisional; Region: PRK00549 326424013591 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 326424013592 putative MPT binding site; other site 326424013593 Competence-damaged protein; Region: CinA; pfam02464 326424013594 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 326424013595 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 326424013596 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 326424013597 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424013598 non-specific DNA binding site [nucleotide binding]; other site 326424013599 salt bridge; other site 326424013600 sequence-specific DNA binding site [nucleotide binding]; other site 326424013601 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 326424013602 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 326424013603 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 326424013604 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 326424013605 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 326424013606 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 326424013607 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 326424013608 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 326424013609 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 326424013610 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 326424013611 dimer interface [polypeptide binding]; other site 326424013612 active site 326424013613 catalytic residue [active] 326424013614 Acetokinase family; Region: Acetate_kinase; cl17229 326424013615 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 326424013616 histidyl-tRNA synthetase; Region: hisS; TIGR00442 326424013617 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 326424013618 dimer interface [polypeptide binding]; other site 326424013619 motif 1; other site 326424013620 active site 326424013621 motif 2; other site 326424013622 motif 3; other site 326424013623 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 326424013624 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 326424013625 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 326424013626 UDP-glucose 4-epimerase; Region: PLN02240 326424013627 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 326424013628 NAD binding site [chemical binding]; other site 326424013629 homodimer interface [polypeptide binding]; other site 326424013630 active site 326424013631 substrate binding site [chemical binding]; other site 326424013632 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 326424013633 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 326424013634 NAD binding site [chemical binding]; other site 326424013635 putative substrate binding site 2 [chemical binding]; other site 326424013636 putative substrate binding site 1 [chemical binding]; other site 326424013637 active site 326424013638 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 326424013639 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 326424013640 nucleotide binding site [chemical binding]; other site 326424013641 putative NEF/HSP70 interaction site [polypeptide binding]; other site 326424013642 SBD interface [polypeptide binding]; other site 326424013643 dihydrodipicolinate reductase; Provisional; Region: PRK00048 326424013644 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 326424013645 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 326424013646 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 326424013647 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 326424013648 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 326424013649 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 326424013650 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 326424013651 RNase E interface [polypeptide binding]; other site 326424013652 trimer interface [polypeptide binding]; other site 326424013653 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 326424013654 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 326424013655 RNase E interface [polypeptide binding]; other site 326424013656 trimer interface [polypeptide binding]; other site 326424013657 active site 326424013658 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 326424013659 putative nucleic acid binding region [nucleotide binding]; other site 326424013660 G-X-X-G motif; other site 326424013661 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 326424013662 RNA binding site [nucleotide binding]; other site 326424013663 domain interface; other site 326424013664 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 326424013665 16S/18S rRNA binding site [nucleotide binding]; other site 326424013666 S13e-L30e interaction site [polypeptide binding]; other site 326424013667 25S rRNA binding site [nucleotide binding]; other site 326424013668 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 326424013669 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 326424013670 active site 326424013671 Riboflavin kinase; Region: Flavokinase; pfam01687 326424013672 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 326424013673 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 326424013674 RNA binding site [nucleotide binding]; other site 326424013675 active site 326424013676 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 326424013677 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 326424013678 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 326424013679 Protein of unknown function (DUF503); Region: DUF503; pfam04456 326424013680 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 326424013681 translation initiation factor IF-2; Region: IF-2; TIGR00487 326424013682 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 326424013683 G1 box; other site 326424013684 putative GEF interaction site [polypeptide binding]; other site 326424013685 GTP/Mg2+ binding site [chemical binding]; other site 326424013686 Switch I region; other site 326424013687 G2 box; other site 326424013688 G3 box; other site 326424013689 Switch II region; other site 326424013690 G4 box; other site 326424013691 G5 box; other site 326424013692 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 326424013693 Translation-initiation factor 2; Region: IF-2; pfam11987 326424013694 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 326424013695 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 326424013696 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 326424013697 NusA N-terminal domain; Region: NusA_N; pfam08529 326424013698 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 326424013699 RNA binding site [nucleotide binding]; other site 326424013700 homodimer interface [polypeptide binding]; other site 326424013701 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 326424013702 G-X-X-G motif; other site 326424013703 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 326424013704 G-X-X-G motif; other site 326424013705 Sm and related proteins; Region: Sm_like; cl00259 326424013706 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 326424013707 putative oligomer interface [polypeptide binding]; other site 326424013708 putative RNA binding site [nucleotide binding]; other site 326424013709 Predicted transcriptional regulator [Transcription]; Region: COG1959 326424013710 Transcriptional regulator; Region: Rrf2; pfam02082 326424013711 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 326424013712 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424013713 dimer interface [polypeptide binding]; other site 326424013714 conserved gate region; other site 326424013715 putative PBP binding loops; other site 326424013716 ABC-ATPase subunit interface; other site 326424013717 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 326424013718 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 326424013719 Walker A/P-loop; other site 326424013720 ATP binding site [chemical binding]; other site 326424013721 Q-loop/lid; other site 326424013722 ABC transporter signature motif; other site 326424013723 Walker B; other site 326424013724 D-loop; other site 326424013725 H-loop/switch region; other site 326424013726 NMT1-like family; Region: NMT1_2; pfam13379 326424013727 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 326424013728 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 326424013729 Predicted acetyltransferase [General function prediction only]; Region: COG3393 326424013730 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 326424013731 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 326424013732 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 326424013733 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 326424013734 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 326424013735 active site 326424013736 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 326424013737 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 326424013738 putative substrate binding region [chemical binding]; other site 326424013739 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 326424013740 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 326424013741 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 326424013742 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 326424013743 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 326424013744 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 326424013745 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326424013746 FeS/SAM binding site; other site 326424013747 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 326424013748 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 326424013749 ribosome recycling factor; Reviewed; Region: frr; PRK00083 326424013750 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 326424013751 hinge region; other site 326424013752 elongation factor Ts; Reviewed; Region: tsf; PRK12332 326424013753 UBA/TS-N domain; Region: UBA; pfam00627 326424013754 Elongation factor TS; Region: EF_TS; pfam00889 326424013755 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 326424013756 rRNA interaction site [nucleotide binding]; other site 326424013757 S8 interaction site; other site 326424013758 putative laminin-1 binding site; other site 326424013759 Peptidase family M23; Region: Peptidase_M23; pfam01551 326424013760 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 326424013761 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 326424013762 active site 326424013763 DNA binding site [nucleotide binding] 326424013764 Int/Topo IB signature motif; other site 326424013765 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 326424013766 DNA protecting protein DprA; Region: dprA; TIGR00732 326424013767 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 326424013768 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 326424013769 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326424013770 Walker A motif; other site 326424013771 ATP binding site [chemical binding]; other site 326424013772 Walker B motif; other site 326424013773 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 326424013774 hypothetical protein; Reviewed; Region: PRK12497 326424013775 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 326424013776 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 326424013777 RNA/DNA hybrid binding site [nucleotide binding]; other site 326424013778 active site 326424013779 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 326424013780 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 326424013781 Catalytic site [active] 326424013782 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 326424013783 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 326424013784 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 326424013785 RimM N-terminal domain; Region: RimM; pfam01782 326424013786 PRC-barrel domain; Region: PRC; pfam05239 326424013787 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 326424013788 signal recognition particle protein; Provisional; Region: PRK10867 326424013789 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 326424013790 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 326424013791 GTP binding site [chemical binding]; other site 326424013792 Signal peptide binding domain; Region: SRP_SPB; pfam02978 326424013793 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 326424013794 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 326424013795 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 326424013796 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 326424013797 Walker A/P-loop; other site 326424013798 ATP binding site [chemical binding]; other site 326424013799 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 326424013800 ABC transporter signature motif; other site 326424013801 Walker B; other site 326424013802 D-loop; other site 326424013803 H-loop/switch region; other site 326424013804 Acylphosphatase; Region: Acylphosphatase; cl00551 326424013805 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 326424013806 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 326424013807 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 326424013808 DNA binding site [nucleotide binding] 326424013809 catalytic residue [active] 326424013810 H2TH interface [polypeptide binding]; other site 326424013811 putative catalytic residues [active] 326424013812 turnover-facilitating residue; other site 326424013813 intercalation triad [nucleotide binding]; other site 326424013814 8OG recognition residue [nucleotide binding]; other site 326424013815 putative reading head residues; other site 326424013816 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 326424013817 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 326424013818 ribonuclease III; Reviewed; Region: rnc; PRK00102 326424013819 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 326424013820 dimerization interface [polypeptide binding]; other site 326424013821 active site 326424013822 metal binding site [ion binding]; metal-binding site 326424013823 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 326424013824 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 326424013825 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 326424013826 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 326424013827 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 326424013828 active site 326424013829 (T/H)XGH motif; other site 326424013830 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 326424013831 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424013832 S-adenosylmethionine binding site [chemical binding]; other site 326424013833 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 326424013834 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 326424013835 generic binding surface II; other site 326424013836 ssDNA binding site; other site 326424013837 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326424013838 ATP binding site [chemical binding]; other site 326424013839 putative Mg++ binding site [ion binding]; other site 326424013840 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326424013841 nucleotide binding region [chemical binding]; other site 326424013842 ATP-binding site [chemical binding]; other site 326424013843 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 326424013844 Domain of unknown function (DUF222); Region: DUF222; pfam02720 326424013845 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 326424013846 active site 326424013847 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 326424013848 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 326424013849 ATP-grasp domain; Region: ATP-grasp_4; cl17255 326424013850 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 326424013851 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 326424013852 AsnC family; Region: AsnC_trans_reg; pfam01037 326424013853 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 326424013854 dimer interface [polypeptide binding]; other site 326424013855 substrate binding site [chemical binding]; other site 326424013856 ATP binding site [chemical binding]; other site 326424013857 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 326424013858 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 326424013859 hinge; other site 326424013860 active site 326424013861 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 326424013862 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 326424013863 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 326424013864 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 326424013865 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 326424013866 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 326424013867 metal binding site [ion binding]; metal-binding site 326424013868 active site 326424013869 I-site; other site 326424013870 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 326424013871 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 326424013872 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 326424013873 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 326424013874 polyphosphate kinase; Provisional; Region: PRK05443 326424013875 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 326424013876 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 326424013877 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 326424013878 putative domain interface [polypeptide binding]; other site 326424013879 putative active site [active] 326424013880 catalytic site [active] 326424013881 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 326424013882 putative domain interface [polypeptide binding]; other site 326424013883 putative active site [active] 326424013884 catalytic site [active] 326424013885 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 326424013886 IHF - DNA interface [nucleotide binding]; other site 326424013887 IHF dimer interface [polypeptide binding]; other site 326424013888 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 326424013889 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 326424013890 substrate binding site [chemical binding]; other site 326424013891 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 326424013892 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 326424013893 substrate binding site [chemical binding]; other site 326424013894 ligand binding site [chemical binding]; other site 326424013895 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 326424013896 Bacterial transcriptional regulator; Region: IclR; pfam01614 326424013897 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424013898 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424013899 active site 326424013900 ATP binding site [chemical binding]; other site 326424013901 substrate binding site [chemical binding]; other site 326424013902 activation loop (A-loop); other site 326424013903 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 326424013904 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326424013905 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326424013906 dimer interface [polypeptide binding]; other site 326424013907 phosphorylation site [posttranslational modification] 326424013908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424013909 ATP binding site [chemical binding]; other site 326424013910 Mg2+ binding site [ion binding]; other site 326424013911 G-X-G motif; other site 326424013912 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 326424013913 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 326424013914 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 326424013915 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 326424013916 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 326424013917 active site 326424013918 catalytic residues [active] 326424013919 metal binding site [ion binding]; metal-binding site 326424013920 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 326424013921 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 326424013922 CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918 326424013923 ligand binding site [chemical binding]; other site 326424013924 flexible hinge region; other site 326424013925 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 326424013926 putative switch regulator; other site 326424013927 non-specific DNA interactions [nucleotide binding]; other site 326424013928 DNA binding site [nucleotide binding] 326424013929 sequence specific DNA binding site [nucleotide binding]; other site 326424013930 putative cAMP binding site [chemical binding]; other site 326424013931 FOG: CBS domain [General function prediction only]; Region: COG0517 326424013932 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_11; cd04624 326424013933 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 326424013934 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 326424013935 homodimer interface [polypeptide binding]; other site 326424013936 substrate-cofactor binding pocket; other site 326424013937 catalytic residue [active] 326424013938 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 326424013939 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 326424013940 Protein of unknown function (DUF1059); Region: DUF1059; pfam06348 326424013941 2-isopropylmalate synthase; Validated; Region: PRK03739 326424013942 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 326424013943 active site 326424013944 catalytic residues [active] 326424013945 metal binding site [ion binding]; metal-binding site 326424013946 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 326424013947 Septum formation; Region: Septum_form; pfam13845 326424013948 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 326424013949 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 326424013950 ligand binding site [chemical binding]; other site 326424013951 NAD binding site [chemical binding]; other site 326424013952 dimerization interface [polypeptide binding]; other site 326424013953 catalytic site [active] 326424013954 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 326424013955 putative L-serine binding site [chemical binding]; other site 326424013956 ketol-acid reductoisomerase; Provisional; Region: PRK05479 326424013957 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 326424013958 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 326424013959 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 326424013960 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 326424013961 putative valine binding site [chemical binding]; other site 326424013962 dimer interface [polypeptide binding]; other site 326424013963 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 326424013964 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 326424013965 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 326424013966 PYR/PP interface [polypeptide binding]; other site 326424013967 dimer interface [polypeptide binding]; other site 326424013968 TPP binding site [chemical binding]; other site 326424013969 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 326424013970 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 326424013971 TPP-binding site [chemical binding]; other site 326424013972 dimer interface [polypeptide binding]; other site 326424013973 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 326424013974 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 326424013975 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 326424013976 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 326424013977 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 326424013978 GatB domain; Region: GatB_Yqey; smart00845 326424013979 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 326424013980 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 326424013981 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 326424013982 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 326424013983 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 326424013984 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 326424013985 nucleotide binding pocket [chemical binding]; other site 326424013986 K-X-D-G motif; other site 326424013987 catalytic site [active] 326424013988 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 326424013989 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 326424013990 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 326424013991 Dimer interface [polypeptide binding]; other site 326424013992 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 326424013993 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 326424013994 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 326424013995 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 326424013996 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 326424013997 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326424013998 catalytic residue [active] 326424013999 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 326424014000 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 326424014001 active site 326424014002 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 326424014003 MarR family; Region: MarR; pfam01047 326424014004 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 326424014005 B12 binding site [chemical binding]; other site 326424014006 cobalt ligand [ion binding]; other site 326424014007 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 326424014008 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 326424014009 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 326424014010 Creatinine amidohydrolase; Region: Creatininase; cl00618 326424014011 classical (c) SDRs; Region: SDR_c; cd05233 326424014012 NAD(P) binding site [chemical binding]; other site 326424014013 active site 326424014014 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 326424014015 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 326424014016 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 326424014017 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 326424014018 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 326424014019 Ligand Binding Site [chemical binding]; other site 326424014020 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 326424014021 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 326424014022 Ligand binding site [chemical binding]; other site 326424014023 Electron transfer flavoprotein domain; Region: ETF; pfam01012 326424014024 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 326424014025 putative catalytic site [active] 326424014026 putative metal binding site [ion binding]; other site 326424014027 putative phosphate binding site [ion binding]; other site 326424014028 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326424014029 enoyl-CoA hydratase; Provisional; Region: PRK07657 326424014030 substrate binding site [chemical binding]; other site 326424014031 oxyanion hole (OAH) forming residues; other site 326424014032 trimer interface [polypeptide binding]; other site 326424014033 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 326424014034 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 326424014035 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 326424014036 active site 326424014037 catalytic site [active] 326424014038 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 326424014039 putative homodimer interface [polypeptide binding]; other site 326424014040 putative active site pocket [active] 326424014041 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 326424014042 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326424014043 acetyl-CoA synthetase; Provisional; Region: PRK00174 326424014044 acyl-activating enzyme (AAE) consensus motif; other site 326424014045 AMP binding site [chemical binding]; other site 326424014046 active site 326424014047 CoA binding site [chemical binding]; other site 326424014048 mannosyl-3-phosphoglycerate phosphatase family; Region: HAD-SF-IIB-MPGP; TIGR01486 326424014049 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 326424014050 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 326424014051 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 326424014052 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 326424014053 Double zinc ribbon; Region: DZR; pfam12773 326424014054 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 326424014055 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 326424014056 Interdomain contacts; other site 326424014057 Cytokine receptor motif; other site 326424014058 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 326424014059 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 326424014060 nucleotide binding site [chemical binding]; other site 326424014061 putative NEF/HSP70 interaction site [polypeptide binding]; other site 326424014062 SBD interface [polypeptide binding]; other site 326424014063 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 326424014064 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 326424014065 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 326424014066 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 326424014067 putative metal binding site [ion binding]; other site 326424014068 hypothetical protein; Provisional; Region: PRK14013 326424014069 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 326424014070 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 326424014071 putative metal binding site [ion binding]; other site 326424014072 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 326424014073 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 326424014074 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 326424014075 active site 326424014076 homodimer interface [polypeptide binding]; other site 326424014077 catalytic site [active] 326424014078 acceptor binding site [chemical binding]; other site 326424014079 trehalose synthase; Region: treS_nterm; TIGR02456 326424014080 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 326424014081 active site 326424014082 catalytic site [active] 326424014083 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 326424014084 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 326424014085 glycogen branching enzyme; Provisional; Region: PRK05402 326424014086 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 326424014087 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 326424014088 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 326424014089 active site 326424014090 catalytic site [active] 326424014091 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 326424014092 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 326424014093 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 326424014094 Domain of unknown function DUF77; Region: DUF77; pfam01910 326424014095 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326424014096 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326424014097 dimer interface [polypeptide binding]; other site 326424014098 phosphorylation site [posttranslational modification] 326424014099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424014100 ATP binding site [chemical binding]; other site 326424014101 Mg2+ binding site [ion binding]; other site 326424014102 G-X-G motif; other site 326424014103 Response regulator receiver domain; Region: Response_reg; pfam00072 326424014104 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 326424014105 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 326424014106 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 326424014107 putative acyltransferase; Provisional; Region: PRK05790 326424014108 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 326424014109 dimer interface [polypeptide binding]; other site 326424014110 active site 326424014111 Family description; Region: VCBS; pfam13517 326424014112 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 326424014113 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326424014114 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 326424014115 DNA binding residues [nucleotide binding] 326424014116 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 326424014117 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 326424014118 NAD(P) binding site [chemical binding]; other site 326424014119 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 326424014120 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 326424014121 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 326424014122 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 326424014123 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 326424014124 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 326424014125 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 326424014126 hypothetical protein; Provisional; Region: PRK03298 326424014127 HD domain; Region: HD_4; pfam13328 326424014128 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 326424014129 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 326424014130 B12 binding site [chemical binding]; other site 326424014131 cobalt ligand [ion binding]; other site 326424014132 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 326424014133 anti sigma factor interaction site; other site 326424014134 regulatory phosphorylation site [posttranslational modification]; other site 326424014135 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 326424014136 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 326424014137 hinge; other site 326424014138 active site 326424014139 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 326424014140 PemK-like protein; Region: PemK; pfam02452 326424014141 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13442 326424014142 gamma subunit interface [polypeptide binding]; other site 326424014143 LBP interface [polypeptide binding]; other site 326424014144 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 326424014145 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 326424014146 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 326424014147 alpha subunit interaction interface [polypeptide binding]; other site 326424014148 Walker A motif; other site 326424014149 ATP binding site [chemical binding]; other site 326424014150 Walker B motif; other site 326424014151 inhibitor binding site; inhibition site 326424014152 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 326424014153 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 326424014154 core domain interface [polypeptide binding]; other site 326424014155 delta subunit interface [polypeptide binding]; other site 326424014156 epsilon subunit interface [polypeptide binding]; other site 326424014157 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 326424014158 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 326424014159 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 326424014160 beta subunit interaction interface [polypeptide binding]; other site 326424014161 Walker A motif; other site 326424014162 ATP binding site [chemical binding]; other site 326424014163 Walker B motif; other site 326424014164 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 326424014165 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 326424014166 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 326424014167 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 326424014168 ATP synthase subunit C; Region: ATP-synt_C; cl00466 326424014169 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 326424014170 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 326424014171 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 326424014172 Mg++ binding site [ion binding]; other site 326424014173 putative catalytic motif [active] 326424014174 substrate binding site [chemical binding]; other site 326424014175 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 326424014176 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 326424014177 dimer interface [polypeptide binding]; other site 326424014178 active site 326424014179 glycine-pyridoxal phosphate binding site [chemical binding]; other site 326424014180 folate binding site [chemical binding]; other site 326424014181 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 326424014182 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 326424014183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424014184 peptide chain release factor 1; Validated; Region: prfA; PRK00591 326424014185 This domain is found in peptide chain release factors; Region: PCRF; smart00937 326424014186 RF-1 domain; Region: RF-1; pfam00472 326424014187 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 326424014188 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 326424014189 transcription termination factor Rho; Provisional; Region: PRK12608 326424014190 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 326424014191 RNA binding site [nucleotide binding]; other site 326424014192 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 326424014193 multimer interface [polypeptide binding]; other site 326424014194 Walker A motif; other site 326424014195 ATP binding site [chemical binding]; other site 326424014196 Walker B motif; other site 326424014197 homoserine kinase; Provisional; Region: PRK01212 326424014198 homoserine kinase; Provisional; Region: PRK01212 326424014199 threonine synthase; Reviewed; Region: PRK06721 326424014200 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 326424014201 homodimer interface [polypeptide binding]; other site 326424014202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326424014203 catalytic residue [active] 326424014204 homoserine dehydrogenase; Provisional; Region: PRK06349 326424014205 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 326424014206 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 326424014207 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 326424014208 diaminopimelate decarboxylase; Region: lysA; TIGR01048 326424014209 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 326424014210 active site 326424014211 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 326424014212 substrate binding site [chemical binding]; other site 326424014213 catalytic residues [active] 326424014214 dimer interface [polypeptide binding]; other site 326424014215 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 326424014216 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 326424014217 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 326424014218 active site 326424014219 HIGH motif; other site 326424014220 KMSK motif region; other site 326424014221 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 326424014222 tRNA binding surface [nucleotide binding]; other site 326424014223 anticodon binding site; other site 326424014224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424014225 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326424014226 active site 326424014227 phosphorylation site [posttranslational modification] 326424014228 intermolecular recognition site; other site 326424014229 dimerization interface [polypeptide binding]; other site 326424014230 Predicted membrane protein (DUF2127); Region: DUF2127; pfam09900 326424014231 Amidohydrolase; Region: Amidohydro_2; pfam04909 326424014232 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 326424014233 Radical SAM superfamily; Region: Radical_SAM; pfam04055 326424014234 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 326424014235 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 326424014236 AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192 326424014237 AIR synthase-related protein, MSMEG_0567 C-terminal family; Region: MSMEG_0567_Cter; TIGR04050 326424014238 dimerization interface [polypeptide binding]; other site 326424014239 putative ATP binding site [chemical binding]; other site 326424014240 Predicted amidohydrolase [General function prediction only]; Region: COG0388 326424014241 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 326424014242 active site 326424014243 catalytic triad [active] 326424014244 dimer interface [polypeptide binding]; other site 326424014245 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 326424014246 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 326424014247 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 326424014248 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 326424014249 Penicillinase repressor; Region: Pencillinase_R; cl17580 326424014250 Peptidase family M48; Region: Peptidase_M48; cl12018 326424014251 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 326424014252 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 326424014253 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 326424014254 metal binding site [ion binding]; metal-binding site 326424014255 active site 326424014256 I-site; other site 326424014257 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 326424014258 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 326424014259 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 326424014260 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 326424014261 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326424014262 catalytic residue [active] 326424014263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424014264 S-adenosylmethionine binding site [chemical binding]; other site 326424014265 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 326424014266 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 326424014267 Part of AAA domain; Region: AAA_19; pfam13245 326424014268 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 326424014269 Part of AAA domain; Region: AAA_19; pfam13245 326424014270 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 326424014271 AAA domain; Region: AAA_12; pfam13087 326424014272 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 326424014273 putative active site [active] 326424014274 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 326424014275 thiamine monophosphate kinase; Provisional; Region: PRK05731 326424014276 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 326424014277 ATP binding site [chemical binding]; other site 326424014278 dimerization interface [polypeptide binding]; other site 326424014279 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 326424014280 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 326424014281 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 326424014282 TPP-binding site [chemical binding]; other site 326424014283 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 326424014284 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 326424014285 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 326424014286 NAD(P) binding site [chemical binding]; other site 326424014287 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 326424014288 Malic enzyme, N-terminal domain; Region: malic; pfam00390 326424014289 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 326424014290 NAD(P) binding pocket [chemical binding]; other site 326424014291 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 326424014292 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 326424014293 substrate binding pocket [chemical binding]; other site 326424014294 membrane-bound complex binding site; other site 326424014295 hinge residues; other site 326424014296 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 326424014297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424014298 dimer interface [polypeptide binding]; other site 326424014299 conserved gate region; other site 326424014300 putative PBP binding loops; other site 326424014301 ABC-ATPase subunit interface; other site 326424014302 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 326424014303 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 326424014304 Walker A/P-loop; other site 326424014305 ATP binding site [chemical binding]; other site 326424014306 Q-loop/lid; other site 326424014307 ABC transporter signature motif; other site 326424014308 Walker B; other site 326424014309 D-loop; other site 326424014310 H-loop/switch region; other site 326424014311 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 326424014312 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326424014313 Coenzyme A binding pocket [chemical binding]; other site 326424014314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 326424014315 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 326424014316 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326424014317 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 326424014318 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 326424014319 DNA binding residues [nucleotide binding] 326424014320 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 326424014321 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 326424014322 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 326424014323 active site 326424014324 metal binding site [ion binding]; metal-binding site 326424014325 catalytic site [active] 326424014326 Transcription factor WhiB; Region: Whib; pfam02467 326424014327 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 326424014328 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 326424014329 Histidine kinase; Region: HisKA_2; pfam07568 326424014330 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424014331 ATP binding site [chemical binding]; other site 326424014332 Mg2+ binding site [ion binding]; other site 326424014333 G-X-G motif; other site 326424014334 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 326424014335 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 326424014336 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326424014337 catalytic residue [active] 326424014338 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 326424014339 biotin synthase; Validated; Region: PRK06256 326424014340 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326424014341 FeS/SAM binding site; other site 326424014342 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 326424014343 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 326424014344 carboxyltransferase (CT) interaction site; other site 326424014345 biotinylation site [posttranslational modification]; other site 326424014346 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 326424014347 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424014348 NAD(P) binding site [chemical binding]; other site 326424014349 active site 326424014350 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 326424014351 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 326424014352 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326424014353 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 326424014354 DNA binding residues [nucleotide binding] 326424014355 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 326424014356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 326424014357 Amidase; Region: Amidase; cl11426 326424014358 Amidase; Region: Amidase; cl11426 326424014359 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 326424014360 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 326424014361 hinge; other site 326424014362 active site 326424014363 ribosome small subunit-dependent GTPase A; Region: TIGR00157 326424014364 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 326424014365 GTPase/Zn-binding domain interface [polypeptide binding]; other site 326424014366 GTP/Mg2+ binding site [chemical binding]; other site 326424014367 G4 box; other site 326424014368 G1 box; other site 326424014369 Switch I region; other site 326424014370 G2 box; other site 326424014371 G3 box; other site 326424014372 Switch II region; other site 326424014373 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 326424014374 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 326424014375 active site 326424014376 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 326424014377 catalytic site [active] 326424014378 active site 326424014379 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 326424014380 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 326424014381 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 326424014382 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 326424014383 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 326424014384 tetrameric interface [polypeptide binding]; other site 326424014385 NAD binding site [chemical binding]; other site 326424014386 catalytic residues [active] 326424014387 substrate binding site [chemical binding]; other site 326424014388 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 326424014389 FAD dependent oxidoreductase; Region: DAO; pfam01266 326424014390 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 326424014391 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 326424014392 inhibitor-cofactor binding pocket; inhibition site 326424014393 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326424014394 catalytic residue [active] 326424014395 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 326424014396 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 326424014397 putative DNA binding site [nucleotide binding]; other site 326424014398 putative Zn2+ binding site [ion binding]; other site 326424014399 AsnC family; Region: AsnC_trans_reg; pfam01037 326424014400 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 326424014401 Uncharacterized conserved protein [Function unknown]; Region: COG1615 326424014402 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 326424014403 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 326424014404 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 326424014405 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 326424014406 MoaE homodimer interface [polypeptide binding]; other site 326424014407 MoaD interaction [polypeptide binding]; other site 326424014408 active site residues [active] 326424014409 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 326424014410 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 326424014411 ABC1 family; Region: ABC1; pfam03109 326424014412 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 326424014413 active site 326424014414 ATP binding site [chemical binding]; other site 326424014415 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 326424014416 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 326424014417 Transcription factor WhiB; Region: Whib; pfam02467 326424014418 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 326424014419 Family description; Region: UvrD_C_2; pfam13538 326424014420 HRDC domain; Region: HRDC; pfam00570 326424014421 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 326424014422 catalytic residues [active] 326424014423 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 326424014424 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 326424014425 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 326424014426 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 326424014427 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 326424014428 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 326424014429 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 326424014430 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 326424014431 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 326424014432 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 326424014433 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 326424014434 DNA binding residues [nucleotide binding] 326424014435 drug binding residues [chemical binding]; other site 326424014436 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 326424014437 AAA domain; Region: AAA_30; pfam13604 326424014438 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 326424014439 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 326424014440 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 326424014441 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 326424014442 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 326424014443 DNA binding site [nucleotide binding] 326424014444 active site 326424014445 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 326424014446 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 326424014447 ATP binding site [chemical binding]; other site 326424014448 substrate interface [chemical binding]; other site 326424014449 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 326424014450 active site residue [active] 326424014451 CsbD-like; Region: CsbD; pfam05532 326424014452 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 326424014453 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 326424014454 putative DNA binding site [nucleotide binding]; other site 326424014455 putative homodimer interface [polypeptide binding]; other site 326424014456 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 326424014457 nucleotide binding site [chemical binding]; other site 326424014458 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424014459 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424014460 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 326424014461 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 326424014462 dinuclear metal binding motif [ion binding]; other site 326424014463 DEAD-like helicases superfamily; Region: DEXDc; smart00487 326424014464 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 326424014465 ATP binding site [chemical binding]; other site 326424014466 Mg++ binding site [ion binding]; other site 326424014467 motif III; other site 326424014468 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326424014469 nucleotide binding region [chemical binding]; other site 326424014470 ATP-binding site [chemical binding]; other site 326424014471 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 326424014472 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 326424014473 P-loop; other site 326424014474 Magnesium ion binding site [ion binding]; other site 326424014475 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 326424014476 Magnesium ion binding site [ion binding]; other site 326424014477 Domain of unknown function DUF21; Region: DUF21; pfam01595 326424014478 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 326424014479 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 326424014480 Transporter associated domain; Region: CorC_HlyC; smart01091 326424014481 Domain of unknown function DUF21; Region: DUF21; pfam01595 326424014482 FOG: CBS domain [General function prediction only]; Region: COG0517 326424014483 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 326424014484 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 326424014485 hypothetical protein; Provisional; Region: PRK08912 326424014486 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326424014487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326424014488 homodimer interface [polypeptide binding]; other site 326424014489 catalytic residue [active] 326424014490 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 326424014491 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 326424014492 hypothetical protein; Provisional; Region: PRK07857 326424014493 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 326424014494 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 326424014495 MgtE intracellular N domain; Region: MgtE_N; smart00924 326424014496 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 326424014497 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 326424014498 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424014499 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326424014500 active site 326424014501 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 326424014502 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 326424014503 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 326424014504 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 326424014505 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 326424014506 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 326424014507 putative metal binding site [ion binding]; other site 326424014508 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 326424014509 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 326424014510 putative active site [active] 326424014511 putative catalytic site [active] 326424014512 PhoD-like phosphatase; Region: PhoD; pfam09423 326424014513 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 326424014514 putative active site [active] 326424014515 putative metal binding site [ion binding]; other site 326424014516 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 326424014517 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 326424014518 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 326424014519 D-pathway; other site 326424014520 Putative ubiquinol binding site [chemical binding]; other site 326424014521 Low-spin heme (heme b) binding site [chemical binding]; other site 326424014522 Putative water exit pathway; other site 326424014523 Binuclear center (heme o3/CuB) [ion binding]; other site 326424014524 K-pathway; other site 326424014525 Putative proton exit pathway; other site 326424014526 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 326424014527 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 326424014528 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 326424014529 inhibitor-cofactor binding pocket; inhibition site 326424014530 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326424014531 catalytic residue [active] 326424014532 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 326424014533 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 326424014534 NAD(P) binding site [chemical binding]; other site 326424014535 catalytic residues [active] 326424014536 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 326424014537 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 326424014538 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 326424014539 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 326424014540 MarR family; Region: MarR; pfam01047 326424014541 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 326424014542 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 326424014543 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 326424014544 sec-independent translocase; Provisional; Region: PRK01371 326424014545 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 326424014546 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 326424014547 Putative zinc-finger; Region: zf-HC2; pfam13490 326424014548 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 326424014549 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326424014550 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 326424014551 DNA binding residues [nucleotide binding] 326424014552 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 326424014553 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424014554 S-adenosylmethionine binding site [chemical binding]; other site 326424014555 multifunctional aminopeptidase A; Provisional; Region: PRK00913 326424014556 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 326424014557 interface (dimer of trimers) [polypeptide binding]; other site 326424014558 Substrate-binding/catalytic site; other site 326424014559 Zn-binding sites [ion binding]; other site 326424014560 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 326424014561 DivIVA domain; Region: DivI1A_domain; TIGR03544 326424014562 dihydropteroate synthase; Region: DHPS; TIGR01496 326424014563 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 326424014564 substrate binding pocket [chemical binding]; other site 326424014565 dimer interface [polypeptide binding]; other site 326424014566 inhibitor binding site; inhibition site 326424014567 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 326424014568 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 326424014569 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 326424014570 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 326424014571 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 326424014572 active site 326424014573 catalytic triad [active] 326424014574 oxyanion hole [active] 326424014575 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 326424014576 sugar binding site [chemical binding]; other site 326424014577 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 326424014578 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 326424014579 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 326424014580 DXD motif; other site 326424014581 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 326424014582 Bacterial sugar transferase; Region: Bac_transf; pfam02397 326424014583 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 326424014584 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 326424014585 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 326424014586 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 326424014587 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 326424014588 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 326424014589 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 326424014590 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 326424014591 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 326424014592 active site 326424014593 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 326424014594 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 326424014595 Ligand binding site; other site 326424014596 Putative Catalytic site; other site 326424014597 DXD motif; other site 326424014598 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 326424014599 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 326424014600 active site 326424014601 catalytic residues [active] 326424014602 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 326424014603 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 326424014604 metal binding site [ion binding]; metal-binding site 326424014605 putative dimer interface [polypeptide binding]; other site 326424014606 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 326424014607 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 326424014608 trimer interface [polypeptide binding]; other site 326424014609 active site 326424014610 substrate binding site [chemical binding]; other site 326424014611 CoA binding site [chemical binding]; other site 326424014612 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 326424014613 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326424014614 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326424014615 homodimer interface [polypeptide binding]; other site 326424014616 catalytic residue [active] 326424014617 Ferredoxin [Energy production and conversion]; Region: COG1146 326424014618 4Fe-4S binding domain; Region: Fer4; pfam00037 326424014619 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 326424014620 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 326424014621 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 326424014622 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 326424014623 protein binding site [polypeptide binding]; other site 326424014624 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 326424014625 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 326424014626 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 326424014627 G1 box; other site 326424014628 putative GEF interaction site [polypeptide binding]; other site 326424014629 GTP/Mg2+ binding site [chemical binding]; other site 326424014630 Switch I region; other site 326424014631 G2 box; other site 326424014632 G3 box; other site 326424014633 Switch II region; other site 326424014634 G4 box; other site 326424014635 G5 box; other site 326424014636 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 326424014637 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 326424014638 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 326424014639 active site 326424014640 8-oxo-dGMP binding site [chemical binding]; other site 326424014641 nudix motif; other site 326424014642 metal binding site [ion binding]; metal-binding site 326424014643 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 326424014644 DCoH dimer interaction site [polypeptide binding]; other site 326424014645 substrate binding site [chemical binding]; other site 326424014646 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 326424014647 Protein of unknown function (DUF952); Region: DUF952; pfam06108 326424014648 GTP-binding protein YchF; Reviewed; Region: PRK09601 326424014649 YchF GTPase; Region: YchF; cd01900 326424014650 G1 box; other site 326424014651 GTP/Mg2+ binding site [chemical binding]; other site 326424014652 Switch I region; other site 326424014653 G2 box; other site 326424014654 Switch II region; other site 326424014655 G3 box; other site 326424014656 G4 box; other site 326424014657 G5 box; other site 326424014658 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 326424014659 RmuC family; Region: RmuC; pfam02646 326424014660 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 326424014661 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 326424014662 putative active site [active] 326424014663 putative metal binding site [ion binding]; other site 326424014664 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 326424014665 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 326424014666 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 326424014667 putative active site [active] 326424014668 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 326424014669 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 326424014670 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 326424014671 generic binding surface I; other site 326424014672 generic binding surface II; other site 326424014673 Exonuclease VII, large subunit; Region: Exonuc_VII_L; pfam02601 326424014674 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 326424014675 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 326424014676 fumarate hydratase; Reviewed; Region: fumC; PRK00485 326424014677 aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596 326424014678 active sites [active] 326424014679 tetramer interface [polypeptide binding]; other site 326424014680 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 326424014681 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 326424014682 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326424014683 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 326424014684 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 326424014685 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 326424014686 substrate binding site [chemical binding]; other site 326424014687 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 326424014688 ATP binding site [chemical binding]; other site 326424014689 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 326424014690 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 326424014691 active site 326424014692 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326424014693 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 326424014694 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 326424014695 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 326424014696 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 326424014697 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 326424014698 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 326424014699 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 326424014700 catalytic loop [active] 326424014701 iron binding site [ion binding]; other site 326424014702 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 326424014703 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 326424014704 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 326424014705 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 326424014706 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 326424014707 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 326424014708 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 326424014709 intersubunit interface [polypeptide binding]; other site 326424014710 active site 326424014711 Zn2+ binding site [ion binding]; other site 326424014712 Isochorismatase family; Region: Isochorismatase; pfam00857 326424014713 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 326424014714 catalytic triad [active] 326424014715 conserved cis-peptide bond; other site 326424014716 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 326424014717 active site 326424014718 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326424014719 classical (c) SDRs; Region: SDR_c; cd05233 326424014720 NAD(P) binding site [chemical binding]; other site 326424014721 active site 326424014722 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 326424014723 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 326424014724 iron-sulfur cluster [ion binding]; other site 326424014725 [2Fe-2S] cluster binding site [ion binding]; other site 326424014726 Homotrimeric ring hydroxylase; Region: Aromatic_hydrox; pfam11723 326424014727 hydrophobic ligand binding site; other site 326424014728 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326424014729 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 326424014730 active site 326424014731 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 326424014732 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 326424014733 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 326424014734 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 326424014735 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 326424014736 Transcriptional regulators [Transcription]; Region: GntR; COG1802 326424014737 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326424014738 DNA-binding site [nucleotide binding]; DNA binding site 326424014739 FCD domain; Region: FCD; pfam07729 326424014740 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 326424014741 Amidase; Region: Amidase; cl11426 326424014742 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 326424014743 dimer interface [polypeptide binding]; other site 326424014744 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326424014745 metal binding site [ion binding]; metal-binding site 326424014746 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 326424014747 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326424014748 DNA-binding site [nucleotide binding]; DNA binding site 326424014749 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 326424014750 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 326424014751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424014752 putative substrate translocation pore; other site 326424014753 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424014754 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424014755 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 326424014756 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326424014757 Walker A/P-loop; other site 326424014758 ATP binding site [chemical binding]; other site 326424014759 Q-loop/lid; other site 326424014760 ABC transporter signature motif; other site 326424014761 Walker B; other site 326424014762 D-loop; other site 326424014763 H-loop/switch region; other site 326424014764 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 326424014765 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326424014766 Walker A/P-loop; other site 326424014767 ATP binding site [chemical binding]; other site 326424014768 Q-loop/lid; other site 326424014769 ABC transporter signature motif; other site 326424014770 Walker B; other site 326424014771 D-loop; other site 326424014772 H-loop/switch region; other site 326424014773 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 326424014774 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 326424014775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424014776 dimer interface [polypeptide binding]; other site 326424014777 conserved gate region; other site 326424014778 putative PBP binding loops; other site 326424014779 ABC-ATPase subunit interface; other site 326424014780 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 326424014781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424014782 dimer interface [polypeptide binding]; other site 326424014783 ABC-ATPase subunit interface; other site 326424014784 putative PBP binding loops; other site 326424014785 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 326424014786 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 326424014787 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 326424014788 active site 326424014789 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 326424014790 non-prolyl cis peptide bond; other site 326424014791 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326424014792 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 326424014793 active site 326424014794 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 326424014795 non-prolyl cis peptide bond; other site 326424014796 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 326424014797 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 326424014798 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424014799 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424014800 active site 326424014801 ATP binding site [chemical binding]; other site 326424014802 substrate binding site [chemical binding]; other site 326424014803 activation loop (A-loop); other site 326424014804 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 326424014805 nudix motif; other site 326424014806 adenylate kinase; Region: adk; TIGR01351 326424014807 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 326424014808 AMP-binding site [chemical binding]; other site 326424014809 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 326424014810 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 326424014811 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 326424014812 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 326424014813 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326424014814 active site 326424014815 motif I; other site 326424014816 motif II; other site 326424014817 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326424014818 methionine sulfoxide reductase A; Provisional; Region: PRK00058 326424014819 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 326424014820 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 326424014821 putative active site [active] 326424014822 PhoH-like protein; Region: PhoH; pfam02562 326424014823 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 326424014824 active site 326424014825 substrate-binding site [chemical binding]; other site 326424014826 metal-binding site [ion binding] 326424014827 GTP binding site [chemical binding]; other site 326424014828 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 326424014829 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 326424014830 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 326424014831 catalytic residues [active] 326424014832 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 326424014833 active site 326424014834 HIGH motif; other site 326424014835 nucleotide binding site [chemical binding]; other site 326424014836 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 326424014837 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 326424014838 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 326424014839 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 326424014840 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 326424014841 active site 326424014842 KMSKS motif; other site 326424014843 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 326424014844 tRNA binding surface [nucleotide binding]; other site 326424014845 Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264 326424014846 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 326424014847 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 326424014848 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 326424014849 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 326424014850 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 326424014851 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 326424014852 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 326424014853 metal ion-dependent adhesion site (MIDAS); other site 326424014854 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 326424014855 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 326424014856 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 326424014857 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 326424014858 active site 326424014859 catalytic triad [active] 326424014860 oxyanion hole [active] 326424014861 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 326424014862 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 326424014863 Bax inhibitor 1 like; Region: BaxI_1; cl17691 326424014864 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 326424014865 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326424014866 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 326424014867 ligand binding site [chemical binding]; other site 326424014868 active site 326424014869 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 326424014870 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 326424014871 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 326424014872 Protein of unknown function (DUF501); Region: DUF501; cl00652 326424014873 Septum formation initiator; Region: DivIC; pfam04977 326424014874 enolase; Provisional; Region: eno; PRK00077 326424014875 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 326424014876 dimer interface [polypeptide binding]; other site 326424014877 metal binding site [ion binding]; metal-binding site 326424014878 substrate binding pocket [chemical binding]; other site 326424014879 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 326424014880 tandem repeat interface [polypeptide binding]; other site 326424014881 oligomer interface [polypeptide binding]; other site 326424014882 active site residues [active] 326424014883 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 326424014884 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 326424014885 tandem repeat interface [polypeptide binding]; other site 326424014886 oligomer interface [polypeptide binding]; other site 326424014887 active site residues [active] 326424014888 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 326424014889 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 326424014890 homodimer interface [polypeptide binding]; other site 326424014891 metal binding site [ion binding]; metal-binding site 326424014892 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 326424014893 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 326424014894 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326424014895 ATP binding site [chemical binding]; other site 326424014896 putative Mg++ binding site [ion binding]; other site 326424014897 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326424014898 nucleotide binding region [chemical binding]; other site 326424014899 ATP-binding site [chemical binding]; other site 326424014900 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 326424014901 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 326424014902 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 326424014903 DNA binding residues [nucleotide binding] 326424014904 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 326424014905 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 326424014906 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 326424014907 active site 326424014908 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 326424014909 Domain of unknown function (DUF2172); Region: DUF2172; pfam09940 326424014910 metal binding site [ion binding]; metal-binding site 326424014911 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 326424014912 substrate binding site; other site 326424014913 dimer interface; other site 326424014914 short chain dehydrogenase; Provisional; Region: PRK08219 326424014915 classical (c) SDRs; Region: SDR_c; cd05233 326424014916 NAD(P) binding site [chemical binding]; other site 326424014917 active site 326424014918 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 326424014919 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 326424014920 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 326424014921 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_11; cd13126 326424014922 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 326424014923 Methyltransferase domain; Region: Methyltransf_23; pfam13489 326424014924 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424014925 S-adenosylmethionine binding site [chemical binding]; other site 326424014926 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 326424014927 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 326424014928 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 326424014929 extended (e) SDRs; Region: SDR_e; cd08946 326424014930 NAD(P) binding site [chemical binding]; other site 326424014931 active site 326424014932 substrate binding site [chemical binding]; other site 326424014933 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 326424014934 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 326424014935 trimer interface [polypeptide binding]; other site 326424014936 active site 326424014937 substrate binding site [chemical binding]; other site 326424014938 CoA binding site [chemical binding]; other site 326424014939 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 326424014940 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 326424014941 Acid Phosphatase; Region: Acid_PPase; cl17256 326424014942 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 326424014943 active site 326424014944 catalytic residues [active] 326424014945 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 326424014946 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 326424014947 active site 326424014948 HIGH motif; other site 326424014949 dimer interface [polypeptide binding]; other site 326424014950 KMSKS motif; other site 326424014951 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 326424014952 RNA binding surface [nucleotide binding]; other site 326424014953 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 326424014954 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 326424014955 Probable Catalytic site; other site 326424014956 metal-binding site 326424014957 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 326424014958 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 326424014959 DXD motif; other site 326424014960 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326424014961 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 326424014962 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 326424014963 putative active site [active] 326424014964 catalytic residue [active] 326424014965 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 326424014966 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 326424014967 5S rRNA interface [nucleotide binding]; other site 326424014968 CTC domain interface [polypeptide binding]; other site 326424014969 L16 interface [polypeptide binding]; other site 326424014970 Asp23 family; Region: Asp23; cl00574 326424014971 DnaJ_C chaperone protein; Provisional; Region: PTZ00037 326424014972 Asp23 family; Region: Asp23; pfam03780 326424014973 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 326424014974 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 326424014975 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326424014976 ABC transporter; Region: ABC_tran_2; pfam12848 326424014977 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326424014978 Fatty acid desaturase; Region: FA_desaturase; pfam00487 326424014979 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 326424014980 Di-iron ligands [ion binding]; other site 326424014981 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 326424014982 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 326424014983 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 326424014984 Substrate binding site; other site 326424014985 Mg++ binding site; other site 326424014986 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 326424014987 active site 326424014988 substrate binding site [chemical binding]; other site 326424014989 CoA binding site [chemical binding]; other site 326424014990 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 326424014991 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 326424014992 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326424014993 active site 326424014994 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 326424014995 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 326424014996 active site 326424014997 HIGH motif; other site 326424014998 dimer interface [polypeptide binding]; other site 326424014999 KMSKS motif; other site 326424015000 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 326424015001 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 326424015002 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 326424015003 active site 326424015004 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 326424015005 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 326424015006 putative active site [active] 326424015007 Predicted methyltransferases [General function prediction only]; Region: COG0313 326424015008 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 326424015009 putative SAM binding site [chemical binding]; other site 326424015010 putative homodimer interface [polypeptide binding]; other site 326424015011 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 326424015012 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 326424015013 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 326424015014 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 326424015015 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 326424015016 phosphopeptide binding site; other site 326424015017 Domain of unknown function (DUF305); Region: DUF305; pfam03713 326424015018 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 326424015019 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 326424015020 Sulfate transporter family; Region: Sulfate_transp; pfam00916 326424015021 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 326424015022 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 326424015023 active site 326424015024 YceI-like domain; Region: YceI; pfam04264 326424015025 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 326424015026 Isochorismatase family; Region: Isochorismatase; pfam00857 326424015027 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 326424015028 catalytic triad [active] 326424015029 conserved cis-peptide bond; other site 326424015030 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 326424015031 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 326424015032 active site 2 [active] 326424015033 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 326424015034 active site 2 [active] 326424015035 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424015036 putative substrate translocation pore; other site 326424015037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424015038 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424015039 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 326424015040 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 326424015041 active site 326424015042 ATP binding site [chemical binding]; other site 326424015043 substrate binding site [chemical binding]; other site 326424015044 activation loop (A-loop); other site 326424015045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 326424015046 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 326424015047 Possible enoyl reductase; Region: MDR_enoyl_red; cd08244 326424015048 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 326424015049 putative NAD(P) binding site [chemical binding]; other site 326424015050 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 326424015051 nudix motif; other site 326424015052 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 326424015053 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 326424015054 DNA binding residues [nucleotide binding] 326424015055 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 326424015056 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 326424015057 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424015058 dimer interface [polypeptide binding]; other site 326424015059 conserved gate region; other site 326424015060 putative PBP binding loops; other site 326424015061 ABC-ATPase subunit interface; other site 326424015062 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424015063 Q-loop/lid; other site 326424015064 ABC transporter signature motif; other site 326424015065 Walker B; other site 326424015066 D-loop; other site 326424015067 H-loop/switch region; other site 326424015068 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 326424015069 FOG: CBS domain [General function prediction only]; Region: COG0517 326424015070 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 326424015071 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 326424015072 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 326424015073 classical (c) SDRs; Region: SDR_c; cd05233 326424015074 NAD(P) binding site [chemical binding]; other site 326424015075 active site 326424015076 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424015077 non-specific DNA binding site [nucleotide binding]; other site 326424015078 salt bridge; other site 326424015079 sequence-specific DNA binding site [nucleotide binding]; other site 326424015080 Resolvase, N terminal domain; Region: Resolvase; smart00857 326424015081 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424015082 non-specific DNA binding site [nucleotide binding]; other site 326424015083 salt bridge; other site 326424015084 sequence-specific DNA binding site [nucleotide binding]; other site 326424015085 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 326424015086 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 326424015087 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 326424015088 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326424015089 ATP binding site [chemical binding]; other site 326424015090 putative Mg++ binding site [ion binding]; other site 326424015091 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326424015092 ATP-binding site [chemical binding]; other site 326424015093 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 326424015094 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 326424015095 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326424015096 ATP binding site [chemical binding]; other site 326424015097 putative Mg++ binding site [ion binding]; other site 326424015098 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326424015099 nucleotide binding region [chemical binding]; other site 326424015100 ATP-binding site [chemical binding]; other site 326424015101 TrwC relaxase; Region: TrwC; pfam08751 326424015102 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 326424015103 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 326424015104 AAA domain; Region: AAA_30; pfam13604 326424015105 Helix-turn-helix domain; Region: HTH_17; cl17695 326424015106 AAA ATPase domain; Region: AAA_16; pfam13191 326424015107 FOG: WD40 repeat [General function prediction only]; Region: COG2319 326424015108 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 326424015109 structural tetrad; other site 326424015110 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 326424015111 structural tetrad; other site 326424015112 FOG: WD40 repeat [General function prediction only]; Region: COG2319 326424015113 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 326424015114 structural tetrad; other site 326424015115 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 326424015116 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 326424015117 LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793 326424015118 active site 326424015119 zinc binding site [ion binding]; other site 326424015120 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 326424015121 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 326424015122 SpaB C-terminal domain; Region: SpaB_C; pfam14028 326424015123 methyltransferase, FxLD system; Region: methyltran_FxLD; TIGR04364 326424015124 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 326424015125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424015126 S-adenosylmethionine binding site [chemical binding]; other site 326424015127 Helix-turn-helix domain; Region: HTH_31; pfam13560 326424015128 Domain of unknown function (DUF397); Region: DUF397; pfam04149 326424015129 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326424015130 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424015131 non-specific DNA binding site [nucleotide binding]; other site 326424015132 salt bridge; other site 326424015133 sequence-specific DNA binding site [nucleotide binding]; other site 326424015134 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 326424015135 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 326424015136 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 326424015137 nudix motif; other site 326424015138 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 326424015139 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 326424015140 DNA binding site [nucleotide binding] 326424015141 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 326424015142 DNA binding site [nucleotide binding] 326424015143 active site 326424015144 Int/Topo IB signature motif; other site 326424015145 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 326424015146 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 326424015147 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 326424015148 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 326424015149 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 326424015150 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326424015151 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424015152 active site 326424015153 phosphorylation site [posttranslational modification] 326424015154 intermolecular recognition site; other site 326424015155 dimerization interface [polypeptide binding]; other site 326424015156 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326424015157 DNA binding site [nucleotide binding] 326424015158 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326424015159 HAMP domain; Region: HAMP; pfam00672 326424015160 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326424015161 dimer interface [polypeptide binding]; other site 326424015162 phosphorylation site [posttranslational modification] 326424015163 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424015164 ATP binding site [chemical binding]; other site 326424015165 Mg2+ binding site [ion binding]; other site 326424015166 G-X-G motif; other site 326424015167 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 326424015168 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 326424015169 NAD(P) binding site [chemical binding]; other site 326424015170 catalytic residues [active] 326424015171 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 326424015172 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 326424015173 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 326424015174 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 326424015175 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 326424015176 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424015177 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 326424015178 Beta-lactamase; Region: Beta-lactamase; pfam00144 326424015179 Pantoate-beta-alanine ligase; Region: PanC; cd00560 326424015180 pantoate--beta-alanine ligase; Region: panC; TIGR00018 326424015181 active site 326424015182 ATP-binding site [chemical binding]; other site 326424015183 pantoate-binding site; other site 326424015184 HXXH motif; other site 326424015185 Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146 326424015186 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 326424015187 NAD(P) binding site [chemical binding]; other site 326424015188 catalytic residues [active] 326424015189 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424015190 S-adenosylmethionine binding site [chemical binding]; other site 326424015191 H+ Antiporter protein; Region: 2A0121; TIGR00900 326424015192 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 326424015193 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 326424015194 ligand binding site [chemical binding]; other site 326424015195 NAD binding site [chemical binding]; other site 326424015196 catalytic site [active] 326424015197 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 326424015198 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 326424015199 tetramer interface [polypeptide binding]; other site 326424015200 active site 326424015201 Mg2+/Mn2+ binding site [ion binding]; other site 326424015202 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 326424015203 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 326424015204 PYR/PP interface [polypeptide binding]; other site 326424015205 dimer interface [polypeptide binding]; other site 326424015206 TPP binding site [chemical binding]; other site 326424015207 Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371 326424015208 TPP-binding site; other site 326424015209 Hydroxyethylphosphoate dehydrogenase (HEPD) catalyzes the reduction of phosphonoacetaldehyde (PnAA) to hydroxyethylphosphoate (HEP); Region: HEPD; cd08182 326424015210 putative active site [active] 326424015211 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 326424015212 metal binding site [ion binding]; metal-binding site 326424015213 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 326424015214 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 326424015215 NAD binding site [chemical binding]; other site 326424015216 ligand binding site [chemical binding]; other site 326424015217 catalytic site [active] 326424015218 4-aminobutyrate aminotransferase, prokaryotic type; Region: GABAtrnsam; TIGR00700 326424015219 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 326424015220 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326424015221 catalytic residue [active] 326424015222 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 326424015223 dinuclear metal binding motif [ion binding]; other site 326424015224 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 326424015225 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 326424015226 putative deacylase active site [active] 326424015227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424015228 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326424015229 active site 326424015230 phosphorylation site [posttranslational modification] 326424015231 intermolecular recognition site; other site 326424015232 dimerization interface [polypeptide binding]; other site 326424015233 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326424015234 DNA binding residues [nucleotide binding] 326424015235 dimerization interface [polypeptide binding]; other site 326424015236 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 326424015237 yiaA/B two helix domain; Region: YiaAB; cl01759 326424015238 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 326424015239 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 326424015240 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 326424015241 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 326424015242 MPT binding site; other site 326424015243 trimer interface [polypeptide binding]; other site 326424015244 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 326424015245 trimer interface [polypeptide binding]; other site 326424015246 dimer interface [polypeptide binding]; other site 326424015247 putative active site [active] 326424015248 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 326424015249 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 326424015250 dimer interface [polypeptide binding]; other site 326424015251 putative functional site; other site 326424015252 putative MPT binding site; other site 326424015253 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 326424015254 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 326424015255 active site 326424015256 tetramer interface; other site 326424015257 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 326424015258 Transcriptional regulators [Transcription]; Region: GntR; COG1802 326424015259 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326424015260 DNA-binding site [nucleotide binding]; DNA binding site 326424015261 FCD domain; Region: FCD; pfam07729 326424015262 Isochorismatase family; Region: Isochorismatase; pfam00857 326424015263 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 326424015264 catalytic triad [active] 326424015265 conserved cis-peptide bond; other site 326424015266 allophanate hydrolase; Provisional; Region: PRK08186 326424015267 Amidase; Region: Amidase; cl11426 326424015268 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 326424015269 putative homodimer interface [polypeptide binding]; other site 326424015270 putative homotetramer interface [polypeptide binding]; other site 326424015271 putative allosteric switch controlling residues; other site 326424015272 putative metal binding site [ion binding]; other site 326424015273 putative homodimer-homodimer interface [polypeptide binding]; other site 326424015274 MarR family; Region: MarR; pfam01047 326424015275 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 326424015276 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; cl17321 326424015277 Protein kinase domain; Region: Pkinase; pfam00069 326424015278 serine/threonine protein kinase; Provisional; Region: PRK14879 326424015279 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 326424015280 substrate binding site [chemical binding]; other site 326424015281 activation loop (A-loop); other site 326424015282 FOG: WD40 repeat [General function prediction only]; Region: COG2319 326424015283 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 326424015284 Response regulator receiver domain; Region: Response_reg; pfam00072 326424015285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424015286 active site 326424015287 phosphorylation site [posttranslational modification] 326424015288 intermolecular recognition site; other site 326424015289 dimerization interface [polypeptide binding]; other site 326424015290 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 326424015291 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 326424015292 dimerization interface [polypeptide binding]; other site 326424015293 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 326424015294 dimerization interface [polypeptide binding]; other site 326424015295 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 326424015296 dimerization interface [polypeptide binding]; other site 326424015297 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 326424015298 dimerization interface [polypeptide binding]; other site 326424015299 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 326424015300 dimerization interface [polypeptide binding]; other site 326424015301 GAF domain; Region: GAF_2; pfam13185 326424015302 GAF domain; Region: GAF; pfam01590 326424015303 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326424015304 dimer interface [polypeptide binding]; other site 326424015305 phosphorylation site [posttranslational modification] 326424015306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424015307 ATP binding site [chemical binding]; other site 326424015308 Mg2+ binding site [ion binding]; other site 326424015309 G-X-G motif; other site 326424015310 Response regulator receiver domain; Region: Response_reg; pfam00072 326424015311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424015312 active site 326424015313 phosphorylation site [posttranslational modification] 326424015314 intermolecular recognition site; other site 326424015315 dimerization interface [polypeptide binding]; other site 326424015316 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 326424015317 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 326424015318 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 326424015319 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 326424015320 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 326424015321 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 326424015322 dimer interface [polypeptide binding]; other site 326424015323 active site 326424015324 ADP-ribose binding site [chemical binding]; other site 326424015325 nudix motif; other site 326424015326 metal binding site [ion binding]; metal-binding site 326424015327 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 326424015328 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 326424015329 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 326424015330 catalytic residue [active] 326424015331 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 326424015332 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 326424015333 inhibitor-cofactor binding pocket; inhibition site 326424015334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326424015335 catalytic residue [active] 326424015336 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 326424015337 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326424015338 catalytic residue [active] 326424015339 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 326424015340 IucA / IucC family; Region: IucA_IucC; pfam04183 326424015341 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 326424015342 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 326424015343 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 326424015344 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 326424015345 IucA / IucC family; Region: IucA_IucC; pfam04183 326424015346 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 326424015347 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 326424015348 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 326424015349 MMPL family; Region: MMPL; pfam03176 326424015350 MMPL family; Region: MMPL; pfam03176 326424015351 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424015352 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424015353 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 326424015354 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 326424015355 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 326424015356 metal binding site [ion binding]; metal-binding site 326424015357 active site 326424015358 I-site; other site 326424015359 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 326424015360 HD domain; Region: HD_5; pfam13487 326424015361 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 326424015362 glycine dehydrogenase; Provisional; Region: PRK05367 326424015363 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 326424015364 tetramer interface [polypeptide binding]; other site 326424015365 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326424015366 catalytic residue [active] 326424015367 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 326424015368 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326424015369 catalytic residue [active] 326424015370 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 326424015371 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 326424015372 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 326424015373 Protein of unknown function DUF58; Region: DUF58; pfam01882 326424015374 MoxR-like ATPases [General function prediction only]; Region: COG0714 326424015375 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326424015376 ATP binding site [chemical binding]; other site 326424015377 Walker A motif; other site 326424015378 Walker B motif; other site 326424015379 arginine finger; other site 326424015380 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 326424015381 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 326424015382 ATP binding site [chemical binding]; other site 326424015383 substrate interface [chemical binding]; other site 326424015384 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424015385 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424015386 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 326424015387 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 326424015388 NAD binding site [chemical binding]; other site 326424015389 catalytic Zn binding site [ion binding]; other site 326424015390 structural Zn binding site [ion binding]; other site 326424015391 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 326424015392 putative hydrophobic ligand binding site [chemical binding]; other site 326424015393 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 326424015394 TOBE domain; Region: TOBE; cl01440 326424015395 TOBE domain; Region: TOBE; cl01440 326424015396 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 326424015397 putative NAD(P) binding site [chemical binding]; other site 326424015398 active site 326424015399 Short repeat of unknown function (DUF308); Region: DUF308; pfam03729 326424015400 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 326424015401 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 326424015402 FAD binding pocket [chemical binding]; other site 326424015403 FAD binding motif [chemical binding]; other site 326424015404 phosphate binding motif [ion binding]; other site 326424015405 beta-alpha-beta structure motif; other site 326424015406 NAD binding pocket [chemical binding]; other site 326424015407 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 326424015408 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 326424015409 catalytic loop [active] 326424015410 iron binding site [ion binding]; other site 326424015411 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 326424015412 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 326424015413 putative di-iron ligands [ion binding]; other site 326424015414 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 326424015415 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 326424015416 dimerization interface [polypeptide binding]; other site 326424015417 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 326424015418 dimerization interface [polypeptide binding]; other site 326424015419 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 326424015420 dimerization interface [polypeptide binding]; other site 326424015421 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 326424015422 dimerization interface [polypeptide binding]; other site 326424015423 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 326424015424 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 326424015425 dimerization interface [polypeptide binding]; other site 326424015426 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 326424015427 dimerization interface [polypeptide binding]; other site 326424015428 GAF domain; Region: GAF_2; pfam13185 326424015429 GAF domain; Region: GAF; pfam01590 326424015430 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 326424015431 dimer interface [polypeptide binding]; other site 326424015432 phosphorylation site [posttranslational modification] 326424015433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326424015434 ATP binding site [chemical binding]; other site 326424015435 Mg2+ binding site [ion binding]; other site 326424015436 G-X-G motif; other site 326424015437 Response regulator receiver domain; Region: Response_reg; pfam00072 326424015438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424015439 active site 326424015440 phosphorylation site [posttranslational modification] 326424015441 intermolecular recognition site; other site 326424015442 dimerization interface [polypeptide binding]; other site 326424015443 ANTAR domain; Region: ANTAR; pfam03861 326424015444 PAS fold; Region: PAS_3; pfam08447 326424015445 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 326424015446 heme pocket [chemical binding]; other site 326424015447 putative active site [active] 326424015448 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 326424015449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424015450 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326424015451 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 326424015452 active site 326424015453 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 326424015454 active site 326424015455 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 326424015456 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 326424015457 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 326424015458 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 326424015459 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 326424015460 Walker A/P-loop; other site 326424015461 ATP binding site [chemical binding]; other site 326424015462 Q-loop/lid; other site 326424015463 ABC transporter signature motif; other site 326424015464 Walker B; other site 326424015465 D-loop; other site 326424015466 H-loop/switch region; other site 326424015467 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 326424015468 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 326424015469 FtsX-like permease family; Region: FtsX; pfam02687 326424015470 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 326424015471 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424015472 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424015473 active site 326424015474 ATP binding site [chemical binding]; other site 326424015475 substrate binding site [chemical binding]; other site 326424015476 activation loop (A-loop); other site 326424015477 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 326424015478 classical (c) SDRs; Region: SDR_c; cd05233 326424015479 NAD(P) binding site [chemical binding]; other site 326424015480 active site 326424015481 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 326424015482 active site 326424015483 ATP binding site [chemical binding]; other site 326424015484 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 326424015485 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 326424015486 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 326424015487 ring oligomerisation interface [polypeptide binding]; other site 326424015488 ATP/Mg binding site [chemical binding]; other site 326424015489 stacking interactions; other site 326424015490 hinge regions; other site 326424015491 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 326424015492 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069 326424015493 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 326424015494 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 326424015495 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 326424015496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 326424015497 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 326424015498 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 326424015499 Beta-lactamase; Region: Beta-lactamase; pfam00144 326424015500 oxidase reductase; Provisional; Region: PTZ00273 326424015501 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 326424015502 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 326424015503 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 326424015504 Hemerythrin-like domain; Region: Hr-like; cd12108 326424015505 Fe binding site [ion binding]; other site 326424015506 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 326424015507 active site 326424015508 metal binding site [ion binding]; metal-binding site 326424015509 nudix motif; other site 326424015510 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 326424015511 ligand binding site [chemical binding]; other site 326424015512 flexible hinge region; other site 326424015513 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 326424015514 substrate binding pocket [chemical binding]; other site 326424015515 substrate-Mg2+ binding site; other site 326424015516 aspartate-rich region 1; other site 326424015517 aspartate-rich region 2; other site 326424015518 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 326424015519 substrate binding pocket [chemical binding]; other site 326424015520 substrate-Mg2+ binding site; other site 326424015521 aspartate-rich region 1; other site 326424015522 aspartate-rich region 2; other site 326424015523 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424015524 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424015525 active site 326424015526 ATP binding site [chemical binding]; other site 326424015527 substrate binding site [chemical binding]; other site 326424015528 activation loop (A-loop); other site 326424015529 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 326424015530 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326424015531 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424015532 Walker A/P-loop; other site 326424015533 ATP binding site [chemical binding]; other site 326424015534 Q-loop/lid; other site 326424015535 ABC transporter signature motif; other site 326424015536 Walker B; other site 326424015537 D-loop; other site 326424015538 H-loop/switch region; other site 326424015539 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 326424015540 Frankia-40 domain; Region: Frankia_40_dom; TIGR03917 326424015541 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326424015542 Polypeptide deformylase; Region: Pep_deformylase; pfam01327 326424015543 active site 326424015544 catalytic residues [active] 326424015545 metal binding site [ion binding]; metal-binding site 326424015546 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 326424015547 N-acetyl-D-glucosamine binding site [chemical binding]; other site 326424015548 catalytic residue [active] 326424015549 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 326424015550 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 326424015551 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 326424015552 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 326424015553 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 326424015554 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 326424015555 metal ion-dependent adhesion site (MIDAS); other site 326424015556 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 326424015557 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 326424015558 phosphopeptide binding site; other site 326424015559 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 326424015560 tRNA synthetases class I (C) catalytic domain; Region: tRNA-synt_1e; pfam01406 326424015561 active site 326424015562 HIGH motif; other site 326424015563 nucleotide binding site [chemical binding]; other site 326424015564 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 326424015565 KMSKS motif; other site 326424015566 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 326424015567 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 326424015568 homotrimer interaction site [polypeptide binding]; other site 326424015569 zinc binding site [ion binding]; other site 326424015570 CDP-binding sites; other site 326424015571 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 326424015572 substrate binding site; other site 326424015573 dimer interface; other site 326424015574 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 326424015575 Protein of unknown function (DUF461); Region: DUF461; cl01071 326424015576 DNA repair protein RadA; Provisional; Region: PRK11823 326424015577 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 326424015578 Walker A motif; other site 326424015579 ATP binding site [chemical binding]; other site 326424015580 Walker B motif; other site 326424015581 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 326424015582 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 326424015583 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 326424015584 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 326424015585 minor groove reading motif; other site 326424015586 helix-hairpin-helix signature motif; other site 326424015587 active site 326424015588 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 326424015589 DNA-binding response regulator CreB; Provisional; Region: PRK11083 326424015590 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326424015591 DNA binding site [nucleotide binding] 326424015592 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 326424015593 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 326424015594 Walker A/P-loop; other site 326424015595 ATP binding site [chemical binding]; other site 326424015596 Q-loop/lid; other site 326424015597 ABC transporter signature motif; other site 326424015598 Walker B; other site 326424015599 D-loop; other site 326424015600 H-loop/switch region; other site 326424015601 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 326424015602 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424015603 dimer interface [polypeptide binding]; other site 326424015604 conserved gate region; other site 326424015605 putative PBP binding loops; other site 326424015606 ABC-ATPase subunit interface; other site 326424015607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424015608 dimer interface [polypeptide binding]; other site 326424015609 conserved gate region; other site 326424015610 putative PBP binding loops; other site 326424015611 ABC-ATPase subunit interface; other site 326424015612 PBP superfamily domain; Region: PBP_like_2; cl17296 326424015613 Frankia-40 domain; Region: Frankia_40_dom; TIGR03917 326424015614 prolyl-tRNA synthetase; Provisional; Region: PRK08661 326424015615 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 326424015616 dimer interface [polypeptide binding]; other site 326424015617 motif 1; other site 326424015618 active site 326424015619 motif 2; other site 326424015620 motif 3; other site 326424015621 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 326424015622 anticodon binding site; other site 326424015623 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 326424015624 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 326424015625 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 326424015626 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 326424015627 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 326424015628 acyl-activating enzyme (AAE) consensus motif; other site 326424015629 active site 326424015630 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 326424015631 putative nucleotide binding site [chemical binding]; other site 326424015632 uridine monophosphate binding site [chemical binding]; other site 326424015633 homohexameric interface [polypeptide binding]; other site 326424015634 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 326424015635 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 326424015636 putative active site [active] 326424015637 putative metal binding site [ion binding]; other site 326424015638 Yqey-like protein; Region: YqeY; cl17540 326424015639 Transglycosylase; Region: Transgly; pfam00912 326424015640 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 326424015641 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 326424015642 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 326424015643 Transcription factor WhiB; Region: Whib; pfam02467 326424015644 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 326424015645 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 326424015646 P loop; other site 326424015647 Nucleotide binding site [chemical binding]; other site 326424015648 DTAP/Switch II; other site 326424015649 Switch I; other site 326424015650 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 326424015651 DTAP/Switch II; other site 326424015652 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 326424015653 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 326424015654 homotrimer interaction site [polypeptide binding]; other site 326424015655 putative active site [active] 326424015656 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 326424015657 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 326424015658 Double zinc ribbon; Region: DZR; pfam12773 326424015659 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 326424015660 cyclase homology domain; Region: CHD; cd07302 326424015661 nucleotidyl binding site; other site 326424015662 metal binding site [ion binding]; metal-binding site 326424015663 dimer interface [polypeptide binding]; other site 326424015664 AAA ATPase domain; Region: AAA_16; pfam13191 326424015665 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 326424015666 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 326424015667 TPR motif; other site 326424015668 binding surface 326424015669 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326424015670 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 326424015671 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 326424015672 ligand binding site [chemical binding]; other site 326424015673 flexible hinge region; other site 326424015674 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 326424015675 putative switch regulator; other site 326424015676 non-specific DNA interactions [nucleotide binding]; other site 326424015677 DNA binding site [nucleotide binding] 326424015678 sequence specific DNA binding site [nucleotide binding]; other site 326424015679 putative cAMP binding site [chemical binding]; other site 326424015680 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 326424015681 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 326424015682 minor groove reading motif; other site 326424015683 helix-hairpin-helix signature motif; other site 326424015684 substrate binding pocket [chemical binding]; other site 326424015685 active site 326424015686 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 326424015687 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 326424015688 putative active site [active] 326424015689 putative CoA binding site [chemical binding]; other site 326424015690 nudix motif; other site 326424015691 metal binding site [ion binding]; metal-binding site 326424015692 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 326424015693 Colicin V production protein; Region: Colicin_V; pfam02674 326424015694 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 326424015695 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 326424015696 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 326424015697 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 326424015698 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 326424015699 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 326424015700 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 326424015701 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 326424015702 ATP binding site [chemical binding]; other site 326424015703 Walker B motif; other site 326424015704 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 326424015705 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 326424015706 MAEBL; Provisional; Region: PTZ00121 326424015707 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 326424015708 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326424015709 ATP binding site [chemical binding]; other site 326424015710 putative Mg++ binding site [ion binding]; other site 326424015711 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326424015712 nucleotide binding region [chemical binding]; other site 326424015713 ATP-binding site [chemical binding]; other site 326424015714 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 326424015715 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 326424015716 anti sigma factor interaction site; other site 326424015717 regulatory phosphorylation site [posttranslational modification]; other site 326424015718 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 326424015719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 326424015720 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 326424015721 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 326424015722 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 326424015723 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 326424015724 active site 326424015725 interdomain interaction site; other site 326424015726 putative metal-binding site [ion binding]; other site 326424015727 nucleotide binding site [chemical binding]; other site 326424015728 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 326424015729 domain I; other site 326424015730 phosphate binding site [ion binding]; other site 326424015731 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 326424015732 domain II; other site 326424015733 domain III; other site 326424015734 nucleotide binding site [chemical binding]; other site 326424015735 DNA binding groove [nucleotide binding] 326424015736 catalytic site [active] 326424015737 domain IV; other site 326424015738 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 326424015739 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 326424015740 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 326424015741 Transmembrane secretion effector; Region: MFS_3; pfam05977 326424015742 thymidylate kinase; Validated; Region: tmk; PRK00698 326424015743 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 326424015744 TMP-binding site; other site 326424015745 ATP-binding site [chemical binding]; other site 326424015746 DNA polymerase III subunit delta'; Validated; Region: PRK07940 326424015747 PSP1 C-terminal conserved region; Region: PSP1; cl00770 326424015748 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424015749 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326424015750 active site 326424015751 phosphorylation site [posttranslational modification] 326424015752 intermolecular recognition site; other site 326424015753 dimerization interface [polypeptide binding]; other site 326424015754 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326424015755 DNA binding site [nucleotide binding] 326424015756 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 326424015757 dimer interface [polypeptide binding]; other site 326424015758 substrate binding site [chemical binding]; other site 326424015759 metal binding sites [ion binding]; metal-binding site 326424015760 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 326424015761 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 326424015762 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 326424015763 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 326424015764 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 326424015765 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 326424015766 Ligand Binding Site [chemical binding]; other site 326424015767 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326424015768 active site 326424015769 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 326424015770 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326424015771 Walker A motif; other site 326424015772 ATP binding site [chemical binding]; other site 326424015773 Walker B motif; other site 326424015774 arginine finger; other site 326424015775 Peptidase family M41; Region: Peptidase_M41; pfam01434 326424015776 GTP cyclohydrolase I; Provisional; Region: PLN03044 326424015777 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 326424015778 homodecamer interface [polypeptide binding]; other site 326424015779 active site 326424015780 putative catalytic site residues [active] 326424015781 zinc binding site [ion binding]; other site 326424015782 GTP-CH-I/GFRP interaction surface; other site 326424015783 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 326424015784 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 326424015785 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 326424015786 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 326424015787 metal binding site [ion binding]; metal-binding site 326424015788 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326424015789 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 326424015790 active site 326424015791 motif I; other site 326424015792 motif II; other site 326424015793 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 326424015794 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326424015795 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424015796 non-specific DNA binding site [nucleotide binding]; other site 326424015797 salt bridge; other site 326424015798 sequence-specific DNA binding site [nucleotide binding]; other site 326424015799 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 326424015800 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 326424015801 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 326424015802 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 326424015803 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 326424015804 NAD(P) binding site [chemical binding]; other site 326424015805 Nitroreductase family; Region: Nitroreductase; pfam00881 326424015806 FMN binding site [chemical binding]; other site 326424015807 dimer interface [polypeptide binding]; other site 326424015808 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 326424015809 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 326424015810 DNA binding residues [nucleotide binding] 326424015811 integral membrane protein; Region: integ_memb_HG; TIGR03954 326424015812 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424015813 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326424015814 non-specific DNA binding site [nucleotide binding]; other site 326424015815 salt bridge; other site 326424015816 sequence-specific DNA binding site [nucleotide binding]; other site 326424015817 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 326424015818 MarR family; Region: MarR; pfam01047 326424015819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424015820 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326424015821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424015822 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 326424015823 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 326424015824 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 326424015825 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 326424015826 Walker A/P-loop; other site 326424015827 ATP binding site [chemical binding]; other site 326424015828 Q-loop/lid; other site 326424015829 ABC transporter signature motif; other site 326424015830 Walker B; other site 326424015831 D-loop; other site 326424015832 H-loop/switch region; other site 326424015833 ANTAR domain; Region: ANTAR; pfam03861 326424015834 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 326424015835 anti sigma factor interaction site; other site 326424015836 regulatory phosphorylation site [posttranslational modification]; other site 326424015837 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 326424015838 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 326424015839 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 326424015840 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 326424015841 putative active site [active] 326424015842 putative dimer interface [polypeptide binding]; other site 326424015843 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 326424015844 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 326424015845 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 326424015846 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 326424015847 ATP binding site [chemical binding]; other site 326424015848 substrate binding site [chemical binding]; other site 326424015849 conserved repeat domain; Region: B_ant_repeat; TIGR01451 326424015850 legume lectins; Region: lectin_L-type; cl14058 326424015851 homotetramer interaction site [polypeptide binding]; other site 326424015852 carbohydrate binding site [chemical binding]; other site 326424015853 metal binding site [ion binding]; metal-binding site 326424015854 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 326424015855 Interdomain contacts; other site 326424015856 Cytokine receptor motif; other site 326424015857 Domain of unknown function DUF11; Region: DUF11; pfam01345 326424015858 Domain of unknown function DUF11; Region: DUF11; cl17728 326424015859 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 326424015860 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 326424015861 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 326424015862 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 326424015863 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 326424015864 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326424015865 motif II; other site 326424015866 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 326424015867 trimer interface [polypeptide binding]; other site 326424015868 active site 326424015869 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 326424015870 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 326424015871 4Fe-4S binding domain; Region: Fer4; pfam00037 326424015872 Cysteine-rich domain; Region: CCG; pfam02754 326424015873 Cysteine-rich domain; Region: CCG; pfam02754 326424015874 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 326424015875 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 326424015876 nucleotide binding site [chemical binding]; other site 326424015877 NEF interaction site [polypeptide binding]; other site 326424015878 SBD interface [polypeptide binding]; other site 326424015879 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 326424015880 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 326424015881 dimer interface [polypeptide binding]; other site 326424015882 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 326424015883 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 326424015884 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 326424015885 HSP70 interaction site [polypeptide binding]; other site 326424015886 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 326424015887 Zn binding sites [ion binding]; other site 326424015888 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 326424015889 dimer interface [polypeptide binding]; other site 326424015890 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 326424015891 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 326424015892 DNA binding residues [nucleotide binding] 326424015893 putative dimer interface [polypeptide binding]; other site 326424015894 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 326424015895 Clp amino terminal domain; Region: Clp_N; pfam02861 326424015896 Clp amino terminal domain; Region: Clp_N; pfam02861 326424015897 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326424015898 Walker A motif; other site 326424015899 ATP binding site [chemical binding]; other site 326424015900 Walker B motif; other site 326424015901 arginine finger; other site 326424015902 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326424015903 Walker A motif; other site 326424015904 ATP binding site [chemical binding]; other site 326424015905 Walker B motif; other site 326424015906 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 326424015907 PPOX class probable F420-dependent enzyme, Rv3369 family; Region: Rv3369; TIGR03667 326424015908 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 326424015909 MMPL family; Region: MMPL; pfam03176 326424015910 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 326424015911 Bacterial PH domain; Region: DUF304; cl01348 326424015912 Bacterial PH domain; Region: DUF304; cl01348 326424015913 Bacterial PH domain; Region: DUF304; pfam03703 326424015914 Bacterial PH domain; Region: DUF304; pfam03703 326424015915 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 326424015916 active site 326424015917 NTP binding site [chemical binding]; other site 326424015918 metal binding triad [ion binding]; metal-binding site 326424015919 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 326424015920 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 326424015921 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 326424015922 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 326424015923 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 326424015924 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 326424015925 active site 326424015926 intersubunit interface [polypeptide binding]; other site 326424015927 zinc binding site [ion binding]; other site 326424015928 Na+ binding site [ion binding]; other site 326424015929 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 326424015930 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 326424015931 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 326424015932 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 326424015933 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 326424015934 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 326424015935 GDP-binding site [chemical binding]; other site 326424015936 ACT binding site; other site 326424015937 IMP binding site; other site 326424015938 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 326424015939 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 326424015940 ATP-grasp domain; Region: ATP-grasp_4; cl17255 326424015941 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 326424015942 AIR carboxylase; Region: AIRC; pfam00731 326424015943 adenylosuccinate lyase; Provisional; Region: PRK07492 326424015944 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 326424015945 tetramer interface [polypeptide binding]; other site 326424015946 active site 326424015947 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 326424015948 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 326424015949 ATP binding site [chemical binding]; other site 326424015950 active site 326424015951 substrate binding site [chemical binding]; other site 326424015952 MMPL family; Region: MMPL; pfam03176 326424015953 MMPL family; Region: MMPL; pfam03176 326424015954 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 326424015955 pantoate--beta-alanine ligase; Region: panC; TIGR00018 326424015956 active site 326424015957 nucleotide binding site [chemical binding]; other site 326424015958 HIGH motif; other site 326424015959 KMSKS motif; other site 326424015960 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 326424015961 tetramerization interface [polypeptide binding]; other site 326424015962 active site 326424015963 L-aspartate oxidase; Provisional; Region: PRK07804 326424015964 L-aspartate oxidase; Provisional; Region: PRK06175 326424015965 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 326424015966 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 326424015967 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 326424015968 dimerization interface [polypeptide binding]; other site 326424015969 active site 326424015970 pantothenate kinase; Reviewed; Region: PRK13318 326424015971 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 326424015972 active site 326424015973 catalytic triad [active] 326424015974 oxyanion hole [active] 326424015975 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 326424015976 YcfA-like protein; Region: YcfA; cl00752 326424015977 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 326424015978 Clp protease ATP binding subunit; Region: clpC; CHL00095 326424015979 Clp amino terminal domain; Region: Clp_N; pfam02861 326424015980 Clp amino terminal domain; Region: Clp_N; pfam02861 326424015981 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326424015982 Walker A motif; other site 326424015983 ATP binding site [chemical binding]; other site 326424015984 Walker B motif; other site 326424015985 arginine finger; other site 326424015986 UvrB/uvrC motif; Region: UVR; pfam02151 326424015987 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326424015988 Walker A motif; other site 326424015989 ATP binding site [chemical binding]; other site 326424015990 Walker B motif; other site 326424015991 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 326424015992 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 326424015993 active site 326424015994 metal binding site [ion binding]; metal-binding site 326424015995 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 326424015996 active site 326424015997 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 326424015998 TrkA-N domain; Region: TrkA_N; pfam02254 326424015999 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 326424016000 EamA-like transporter family; Region: EamA; pfam00892 326424016001 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 326424016002 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 326424016003 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 326424016004 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 326424016005 NAD(P) binding site [chemical binding]; other site 326424016006 RNHCP domain; Region: RNHCP; pfam12647 326424016007 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 326424016008 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 326424016009 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326424016010 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 326424016011 active site 326424016012 motif I; other site 326424016013 motif II; other site 326424016014 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 326424016015 Glycosyltransferase family 20; Region: Glyco_transf_20; pfam00982 326424016016 active site 326424016017 homotetramer interface [polypeptide binding]; other site 326424016018 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326424016019 sucrose-phosphate phosphatase subfamily; Region: SPP-subfamily; TIGR01482 326424016020 active site 326424016021 motif I; other site 326424016022 motif II; other site 326424016023 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 326424016024 threonine synthase; Validated; Region: PRK07591 326424016025 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 326424016026 homodimer interface [polypeptide binding]; other site 326424016027 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326424016028 catalytic residue [active] 326424016029 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 326424016030 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 326424016031 ring oligomerisation interface [polypeptide binding]; other site 326424016032 ATP/Mg binding site [chemical binding]; other site 326424016033 stacking interactions; other site 326424016034 hinge regions; other site 326424016035 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 326424016036 putative active site [active] 326424016037 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 326424016038 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 326424016039 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 326424016040 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326424016041 ATP binding site [chemical binding]; other site 326424016042 putative Mg++ binding site [ion binding]; other site 326424016043 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326424016044 nucleotide binding region [chemical binding]; other site 326424016045 ATP-binding site [chemical binding]; other site 326424016046 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 326424016047 WYL domain; Region: WYL; pfam13280 326424016048 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 326424016049 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 326424016050 catalytic center binding site [active] 326424016051 ATP binding site [chemical binding]; other site 326424016052 Dihydroneopterin aldolase; Region: FolB; smart00905 326424016053 active site 326424016054 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 326424016055 substrate binding pocket [chemical binding]; other site 326424016056 inhibitor binding site; inhibition site 326424016057 Phosphotransferase enzyme family; Region: APH; pfam01636 326424016058 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 326424016059 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 326424016060 active site 326424016061 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 326424016062 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 326424016063 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 326424016064 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 326424016065 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 326424016066 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 326424016067 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 326424016068 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 326424016069 putative active site [active] 326424016070 catalytic triad [active] 326424016071 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 326424016072 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 326424016073 Walker A/P-loop; other site 326424016074 ATP binding site [chemical binding]; other site 326424016075 Q-loop/lid; other site 326424016076 ABC transporter signature motif; other site 326424016077 Walker B; other site 326424016078 D-loop; other site 326424016079 H-loop/switch region; other site 326424016080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424016081 dimer interface [polypeptide binding]; other site 326424016082 conserved gate region; other site 326424016083 putative PBP binding loops; other site 326424016084 ABC-ATPase subunit interface; other site 326424016085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424016086 dimer interface [polypeptide binding]; other site 326424016087 conserved gate region; other site 326424016088 ABC-ATPase subunit interface; other site 326424016089 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 326424016090 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 326424016091 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 326424016092 dimerization interface [polypeptide binding]; other site 326424016093 ATP binding site [chemical binding]; other site 326424016094 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 326424016095 dimerization interface [polypeptide binding]; other site 326424016096 ATP binding site [chemical binding]; other site 326424016097 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 326424016098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326424016099 putative substrate translocation pore; other site 326424016100 futalosine nucleosidase; Region: fut_nucase; TIGR03664 326424016101 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 326424016102 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 326424016103 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 326424016104 putative DNA binding site [nucleotide binding]; other site 326424016105 catalytic residue [active] 326424016106 putative H2TH interface [polypeptide binding]; other site 326424016107 putative catalytic residues [active] 326424016108 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 326424016109 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 326424016110 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 326424016111 active site residue [active] 326424016112 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 326424016113 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 326424016114 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 326424016115 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 326424016116 DNA-binding site [nucleotide binding]; DNA binding site 326424016117 RNA-binding motif; other site 326424016118 Protein kinase domain; Region: Pkinase; pfam00069 326424016119 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424016120 active site 326424016121 ATP binding site [chemical binding]; other site 326424016122 substrate binding site [chemical binding]; other site 326424016123 activation loop (A-loop); other site 326424016124 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 326424016125 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424016126 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424016127 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 326424016128 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 326424016129 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 326424016130 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 326424016131 phosphopeptide binding site; other site 326424016132 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 326424016133 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 326424016134 phosphopeptide binding site; other site 326424016135 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 326424016136 active site 326424016137 BofC C-terminal domain; Region: BofC_C; pfam08955 326424016138 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 326424016139 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 326424016140 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 326424016141 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424016142 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326424016143 active site 326424016144 ATP binding site [chemical binding]; other site 326424016145 substrate binding site [chemical binding]; other site 326424016146 activation loop (A-loop); other site 326424016147 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 326424016148 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326424016149 active site 326424016150 ATP binding site [chemical binding]; other site 326424016151 substrate binding site [chemical binding]; other site 326424016152 activation loop (A-loop); other site 326424016153 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 326424016154 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 326424016155 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 326424016156 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 326424016157 Glutamine amidotransferase class-I; Region: GATase; pfam00117 326424016158 glutamine binding [chemical binding]; other site 326424016159 catalytic triad [active] 326424016160 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 326424016161 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 326424016162 homotrimer interaction site [polypeptide binding]; other site 326424016163 putative active site [active] 326424016164 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 326424016165 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 326424016166 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 326424016167 Rhomboid family; Region: Rhomboid; pfam01694 326424016168 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 326424016169 active site 326424016170 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 326424016171 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 326424016172 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 326424016173 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 326424016174 Ligand Binding Site [chemical binding]; other site 326424016175 Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 326424016176 catalytic site [active] 326424016177 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 326424016178 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 326424016179 dimer interface [polypeptide binding]; other site 326424016180 active site 326424016181 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 326424016182 active site 326424016183 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 326424016184 The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Region: 2A067; TIGR00921 326424016185 Adenosylhomocysteinase; Provisional; Region: PTZ00075 326424016186 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 326424016187 homotetramer interface [polypeptide binding]; other site 326424016188 ligand binding site [chemical binding]; other site 326424016189 catalytic site [active] 326424016190 NAD binding site [chemical binding]; other site 326424016191 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326424016192 Coenzyme A binding pocket [chemical binding]; other site 326424016193 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 326424016194 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 326424016195 substrate binding site [chemical binding]; other site 326424016196 amidase catalytic site [active] 326424016197 Zn binding residues [ion binding]; other site 326424016198 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 326424016199 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 326424016200 adenosine deaminase; Provisional; Region: PRK09358 326424016201 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 326424016202 active site 326424016203 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 326424016204 putative hydrophobic ligand binding site [chemical binding]; other site 326424016205 hypothetical protein; Validated; Region: PRK06186 326424016206 conserved cys residue [active] 326424016207 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326424016208 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 326424016209 DNA-binding site [nucleotide binding]; DNA binding site 326424016210 RNA-binding motif; other site 326424016211 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424016212 S-adenosylmethionine binding site [chemical binding]; other site 326424016213 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 326424016214 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326424016215 active site 326424016216 phosphorylation site [posttranslational modification] 326424016217 intermolecular recognition site; other site 326424016218 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 326424016219 heme-binding site [chemical binding]; other site 326424016220 Predicted transcriptional regulators [Transcription]; Region: COG1733 326424016221 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 326424016222 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 326424016223 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 326424016224 NADP binding site [chemical binding]; other site 326424016225 4Fe-4S binding domain; Region: Fer4; pfam00037 326424016226 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 326424016227 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 326424016228 TPP-binding site [chemical binding]; other site 326424016229 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 326424016230 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 326424016231 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 326424016232 dimer interface [polypeptide binding]; other site 326424016233 PYR/PP interface [polypeptide binding]; other site 326424016234 TPP binding site [chemical binding]; other site 326424016235 substrate binding site [chemical binding]; other site 326424016236 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 326424016237 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 326424016238 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326424016239 catalytic residue [active] 326424016240 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 326424016241 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 326424016242 ATP binding site [chemical binding]; other site 326424016243 substrate interface [chemical binding]; other site 326424016244 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 326424016245 NifU-like domain; Region: NifU; pfam01106 326424016246 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 326424016247 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326424016248 FeS/SAM binding site; other site 326424016249 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 326424016250 NifZ domain; Region: NifZ; pfam04319 326424016251 Nitrogen fixation protein NifW; Region: NifW; pfam03206 326424016252 Rop-like; Region: Rop-like; pfam05082 326424016253 Protein of unknown function, DUF269; Region: DUF269; pfam03270 326424016254 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 326424016255 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 326424016256 nitrogenase molybdenum-cofactor biosynthesis protein NifN; Provisional; Region: PRK14476 326424016257 nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478 326424016258 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 326424016259 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 326424016260 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 326424016261 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 326424016262 MoFe protein beta/alpha subunit interactions; other site 326424016263 Beta subunit P cluster binding residues; other site 326424016264 MoFe protein beta subunit/Fe protein contacts; other site 326424016265 MoFe protein dimer/ dimer interactions; other site 326424016266 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 326424016267 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 326424016268 MoFe protein alpha/beta subunit interactions; other site 326424016269 Alpha subunit P cluster binding residues; other site 326424016270 FeMoco binding residues [chemical binding]; other site 326424016271 MoFe protein alpha subunit/Fe protein contacts; other site 326424016272 MoFe protein dimer/ dimer interactions; other site 326424016273 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 326424016274 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 326424016275 Nucleotide-binding sites [chemical binding]; other site 326424016276 Walker A motif; other site 326424016277 Switch I region of nucleotide binding site; other site 326424016278 Fe4S4 binding sites [ion binding]; other site 326424016279 Switch II region of nucleotide binding site; other site 326424016280 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 326424016281 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 326424016282 active site 326424016283 catalytic residues [active] 326424016284 metal binding site [ion binding]; metal-binding site 326424016285 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 326424016286 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 326424016287 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326424016288 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326424016289 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326424016290 S-adenosylmethionine binding site [chemical binding]; other site 326424016291 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 326424016292 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 326424016293 DNA binding residues [nucleotide binding] 326424016294 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 326424016295 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 326424016296 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 326424016297 DNA binding residues [nucleotide binding] 326424016298 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 326424016299 Frankia-40 domain; Region: Frankia_40_dom; TIGR03917 326424016300 acyl carrier protein; Provisional; Region: acpP; PRK00982 326424016301 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 326424016302 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 326424016303 P-loop; other site 326424016304 Magnesium ion binding site [ion binding]; other site 326424016305 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 326424016306 Magnesium ion binding site [ion binding]; other site 326424016307 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 326424016308 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 326424016309 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 326424016310 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326424016311 Walker A/P-loop; other site 326424016312 ATP binding site [chemical binding]; other site 326424016313 Q-loop/lid; other site 326424016314 ABC transporter signature motif; other site 326424016315 Walker B; other site 326424016316 D-loop; other site 326424016317 H-loop/switch region; other site 326424016318 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 326424016319 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 326424016320 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 326424016321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424016322 dimer interface [polypeptide binding]; other site 326424016323 conserved gate region; other site 326424016324 putative PBP binding loops; other site 326424016325 ABC-ATPase subunit interface; other site 326424016326 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 326424016327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326424016328 dimer interface [polypeptide binding]; other site 326424016329 conserved gate region; other site 326424016330 putative PBP binding loops; other site 326424016331 ABC-ATPase subunit interface; other site 326424016332 hypothetical protein; Provisional; Region: PRK09256 326424016333 Nuclease-related domain; Region: NERD; pfam08378 326424016334 ergothioneine biosynthesis glutamate--cysteine ligase EgtA; Region: EgtA_Cys_ligase; TIGR03444 326424016335 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 326424016336 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 326424016337 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 326424016338 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 326424016339 putative active site [active] 326424016340 putative dimer interface [polypeptide binding]; other site 326424016341 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 326424016342 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 326424016343 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 326424016344 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 326424016345 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 326424016346 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 326424016347 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 326424016348 Walker A motif; other site 326424016349 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 326424016350 replicative DNA helicase; Region: DnaB; TIGR00665 326424016351 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 326424016352 ATP binding site [chemical binding]; other site 326424016353 Walker B motif; other site 326424016354 DNA binding loops [nucleotide binding] 326424016355 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 326424016356 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 326424016357 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 326424016358 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 326424016359 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 326424016360 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 326424016361 dimer interface [polypeptide binding]; other site 326424016362 ssDNA binding site [nucleotide binding]; other site 326424016363 tetramer (dimer of dimers) interface [polypeptide binding]; other site 326424016364 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 326424016365 Predicted integral membrane protein [Function unknown]; Region: COG5650 326424016366 Transglycosylase; Region: Transgly; pfam00912 326424016367 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 326424016368 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 326424016369 Predicted transcriptional regulators [Transcription]; Region: COG1695 326424016370 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 326424016371 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 326424016372 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 326424016373 H+ Antiporter protein; Region: 2A0121; TIGR00900 326424016374 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 326424016375 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 326424016376 active site 326424016377 NTP binding site [chemical binding]; other site 326424016378 metal binding triad [ion binding]; metal-binding site 326424016379 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 326424016380 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 326424016381 Zn2+ binding site [ion binding]; other site 326424016382 Mg2+ binding site [ion binding]; other site 326424016383 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 326424016384 active site 326424016385 Ap6A binding site [chemical binding]; other site 326424016386 nudix motif; other site 326424016387 metal binding site [ion binding]; metal-binding site 326424016388 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 326424016389 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 326424016390 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 326424016391 active site 326424016392 ATP binding site [chemical binding]; other site 326424016393 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 326424016394 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 326424016395 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326424016396 sequence-specific DNA binding site [nucleotide binding]; other site 326424016397 salt bridge; other site 326424016398 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 326424016399 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 326424016400 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326424016401 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 326424016402 catalytic residues [active] 326424016403 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 326424016404 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 326424016405 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 326424016406 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 326424016407 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 326424016408 active site 326424016409 metal binding site [ion binding]; metal-binding site 326424016410 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 326424016411 ParB-like nuclease domain; Region: ParBc; pfam02195 326424016412 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 326424016413 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 326424016414 Magnesium ion binding site [ion binding]; other site 326424016415 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 326424016416 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 326424016417 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 326424016418 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 326424016419 G-X-X-G motif; other site 326424016420 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 326424016421 RxxxH motif; other site 326424016422 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 326424016423 hypothetical protein; Provisional; Region: PRK14376