-- dump date 20140619_100311 -- class Genbank::misc_feature -- table misc_feature_note -- id note 656024000001 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 656024000002 G-X-X-G motif; other site 656024000003 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 656024000004 RxxxH motif; other site 656024000005 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 656024000006 Haemolytic domain; Region: Haemolytic; cl00506 656024000007 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 656024000008 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 656024000009 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 656024000010 Walker A motif; other site 656024000011 ATP binding site [chemical binding]; other site 656024000012 Walker B motif; other site 656024000013 arginine finger; other site 656024000014 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 656024000015 DnaA box-binding interface [nucleotide binding]; other site 656024000016 DNA polymerase III subunit beta; Validated; Region: PRK07761 656024000017 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 656024000018 putative DNA binding surface [nucleotide binding]; other site 656024000019 dimer interface [polypeptide binding]; other site 656024000020 beta-clamp/clamp loader binding surface; other site 656024000021 beta-clamp/translesion DNA polymerase binding surface; other site 656024000022 recombination protein F; Reviewed; Region: recF; PRK00064 656024000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024000024 Walker A/P-loop; other site 656024000025 ATP binding site [chemical binding]; other site 656024000026 Q-loop/lid; other site 656024000027 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024000028 ABC transporter signature motif; other site 656024000029 Walker B; other site 656024000030 D-loop; other site 656024000031 Protein of unknown function (DUF721); Region: DUF721; cl02324 656024000032 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 656024000033 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656024000034 Mg2+ binding site [ion binding]; other site 656024000035 G-X-G motif; other site 656024000036 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 656024000037 anchoring element; other site 656024000038 dimer interface [polypeptide binding]; other site 656024000039 ATP binding site [chemical binding]; other site 656024000040 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 656024000041 active site 656024000042 putative metal-binding site [ion binding]; other site 656024000043 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 656024000044 DNA gyrase subunit A; Validated; Region: PRK05560 656024000045 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 656024000046 CAP-like domain; other site 656024000047 active site 656024000048 primary dimer interface [polypeptide binding]; other site 656024000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 656024000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 656024000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 656024000052 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 656024000053 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 656024000054 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 656024000055 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 656024000056 Transposase; Region: HTH_Tnp_1; cl17663 656024000057 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 656024000058 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 656024000059 iron-sulfur cluster [ion binding]; other site 656024000060 [2Fe-2S] cluster binding site [ion binding]; other site 656024000061 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 656024000062 epoxide hydrolase N-terminal domain-like phosphatase; Region: HAD-1A3-hyp; TIGR02247 656024000063 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 656024000064 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 656024000065 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 656024000066 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 656024000067 Cation efflux family; Region: Cation_efflux; cl00316 656024000068 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 656024000069 nudix motif; other site 656024000070 TIR domain; Region: TIR_2; pfam13676 656024000071 Tetratricopeptide repeat; Region: TPR_12; pfam13424 656024000072 Tetratricopeptide repeat; Region: TPR_10; pfam13374 656024000073 Tetratricopeptide repeat; Region: TPR_10; pfam13374 656024000074 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 656024000075 Transposase; Region: DDE_Tnp_ISL3; pfam01610 656024000076 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 656024000077 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 656024000078 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 656024000079 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 656024000080 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 656024000081 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656024000082 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024000083 WHG domain; Region: WHG; pfam13305 656024000084 Domain of unknown function (DUF385); Region: DUF385; cl04387 656024000085 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 656024000086 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 656024000087 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 656024000088 substrate binding site [chemical binding]; other site 656024000089 putative formyltransferase; Provisional; Region: PRK06988 656024000090 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 656024000091 active site 656024000092 substrate binding site [chemical binding]; other site 656024000093 cosubstrate binding site; other site 656024000094 catalytic site [active] 656024000095 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 656024000096 active site 656024000097 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 656024000098 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 656024000099 Walker A/P-loop; other site 656024000100 ATP binding site [chemical binding]; other site 656024000101 Q-loop/lid; other site 656024000102 ABC transporter signature motif; other site 656024000103 Walker B; other site 656024000104 D-loop; other site 656024000105 H-loop/switch region; other site 656024000106 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 656024000107 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 656024000108 ABC-ATPase subunit interface; other site 656024000109 dimer interface [polypeptide binding]; other site 656024000110 putative PBP binding regions; other site 656024000111 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 656024000112 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 656024000113 ABC-ATPase subunit interface; other site 656024000114 dimer interface [polypeptide binding]; other site 656024000115 putative PBP binding regions; other site 656024000116 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 656024000117 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 656024000118 siderophore binding site; other site 656024000119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 656024000120 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 656024000121 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 656024000122 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024000123 Walker A/P-loop; other site 656024000124 ATP binding site [chemical binding]; other site 656024000125 Q-loop/lid; other site 656024000126 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 656024000127 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024000128 ABC transporter signature motif; other site 656024000129 Walker B; other site 656024000130 D-loop; other site 656024000131 H-loop/switch region; other site 656024000132 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 656024000133 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 656024000134 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 656024000135 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 656024000136 active site 656024000137 DNA binding site [nucleotide binding] 656024000138 Int/Topo IB signature motif; other site 656024000139 Helix-turn-helix domain; Region: HTH_17; pfam12728 656024000140 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 656024000141 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 656024000142 DNA-binding site [nucleotide binding]; DNA binding site 656024000143 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 656024000144 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 656024000145 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 656024000146 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 656024000147 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 656024000148 DXD motif; other site 656024000149 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 656024000150 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 656024000151 FAD binding pocket [chemical binding]; other site 656024000152 FAD binding motif [chemical binding]; other site 656024000153 phosphate binding motif [ion binding]; other site 656024000154 beta-alpha-beta structure motif; other site 656024000155 NAD binding pocket [chemical binding]; other site 656024000156 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 656024000157 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 656024000158 catalytic loop [active] 656024000159 iron binding site [ion binding]; other site 656024000160 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 656024000161 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 656024000162 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 656024000163 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 656024000164 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024000165 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024000166 DNA-binding interface [nucleotide binding]; DNA binding site 656024000167 putative transposase OrfB; Reviewed; Region: PHA02517 656024000168 HTH-like domain; Region: HTH_21; pfam13276 656024000169 Integrase core domain; Region: rve; pfam00665 656024000170 Integrase core domain; Region: rve_3; pfam13683 656024000171 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 656024000172 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 656024000173 non-specific DNA binding site [nucleotide binding]; other site 656024000174 salt bridge; other site 656024000175 sequence-specific DNA binding site [nucleotide binding]; other site 656024000176 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 656024000177 Leucine carboxyl methyltransferase; Region: LCM; cl01306 656024000178 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 656024000179 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 656024000180 Walker A/P-loop; other site 656024000181 ATP binding site [chemical binding]; other site 656024000182 Q-loop/lid; other site 656024000183 ABC transporter signature motif; other site 656024000184 Walker B; other site 656024000185 D-loop; other site 656024000186 H-loop/switch region; other site 656024000187 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 656024000188 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 656024000189 dimer interface [polypeptide binding]; other site 656024000190 conserved gate region; other site 656024000191 putative PBP binding loops; other site 656024000192 ABC-ATPase subunit interface; other site 656024000193 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024000194 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024000195 DNA-binding interface [nucleotide binding]; DNA binding site 656024000196 putative transposase OrfB; Reviewed; Region: PHA02517 656024000197 HTH-like domain; Region: HTH_21; pfam13276 656024000198 Integrase core domain; Region: rve; pfam00665 656024000199 Integrase core domain; Region: rve_3; pfam13683 656024000200 AAA domain; Region: AAA_14; pfam13173 656024000201 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 656024000202 AAA ATPase domain; Region: AAA_16; pfam13191 656024000203 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 656024000204 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 656024000205 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 656024000206 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 656024000207 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 656024000208 substrate binding site [chemical binding]; other site 656024000209 ATP binding site [chemical binding]; other site 656024000210 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 656024000211 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 656024000212 non-specific DNA binding site [nucleotide binding]; other site 656024000213 salt bridge; other site 656024000214 sequence-specific DNA binding site [nucleotide binding]; other site 656024000215 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 656024000216 Polypeptide deformylase; Region: Pep_deformylase; pfam01327 656024000217 active site 656024000218 catalytic residues [active] 656024000219 metal binding site [ion binding]; metal-binding site 656024000220 Frankia-40 domain; Region: Frankia_40_dom; TIGR03917 656024000221 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 656024000222 Homeodomain-like domain; Region: HTH_23; pfam13384 656024000223 Winged helix-turn helix; Region: HTH_29; pfam13551 656024000224 Homeodomain-like domain; Region: HTH_32; pfam13565 656024000225 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024000226 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 656024000227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024000228 Major Facilitator Superfamily; Region: MFS_1; pfam07690 656024000229 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 656024000230 Catalytic domain of Protein Kinases; Region: PKc; cd00180 656024000231 active site 656024000232 ATP binding site [chemical binding]; other site 656024000233 substrate binding site [chemical binding]; other site 656024000234 activation loop (A-loop); other site 656024000235 Bacterial transcriptional activator domain; Region: BTAD; smart01043 656024000236 ImpE protein; Region: ImpE; pfam07024 656024000237 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 656024000238 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 656024000239 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 656024000240 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 656024000241 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 656024000242 PII uridylyl-transferase; Provisional; Region: PRK03381 656024000243 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 656024000244 metal binding triad; other site 656024000245 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 656024000246 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 656024000247 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 656024000248 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 656024000249 Nitrogen regulatory protein P-II; Region: P-II; smart00938 656024000250 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 656024000251 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 656024000252 NlpC/P60 family; Region: NLPC_P60; pfam00877 656024000253 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 656024000254 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 656024000255 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 656024000256 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024000257 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024000258 DNA-binding interface [nucleotide binding]; DNA binding site 656024000259 putative transposase OrfB; Reviewed; Region: PHA02517 656024000260 HTH-like domain; Region: HTH_21; pfam13276 656024000261 Integrase core domain; Region: rve; pfam00665 656024000262 Integrase core domain; Region: rve_3; pfam13683 656024000263 Isochorismatase family; Region: Isochorismatase; pfam00857 656024000264 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 656024000265 catalytic triad [active] 656024000266 conserved cis-peptide bond; other site 656024000267 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 656024000268 DNA-binding site [nucleotide binding]; DNA binding site 656024000269 Integrase core domain; Region: rve_3; pfam13683 656024000270 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 656024000271 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 656024000272 putative active site [active] 656024000273 putative NTP binding site [chemical binding]; other site 656024000274 putative nucleic acid binding site [nucleotide binding]; other site 656024000275 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 656024000276 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 656024000277 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 656024000278 putative active site [active] 656024000279 putative NTP binding site [chemical binding]; other site 656024000280 putative nucleic acid binding site [nucleotide binding]; other site 656024000281 Type II intron maturase; Region: Intron_maturas2; pfam01348 656024000282 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024000283 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024000284 DNA-binding interface [nucleotide binding]; DNA binding site 656024000285 HTH-like domain; Region: HTH_21; pfam13276 656024000286 Integrase core domain; Region: rve; pfam00665 656024000287 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 656024000288 Homeodomain-like domain; Region: HTH_23; pfam13384 656024000289 Winged helix-turn helix; Region: HTH_29; pfam13551 656024000290 Homeodomain-like domain; Region: HTH_32; pfam13565 656024000291 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024000292 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 656024000293 chaperone protein DnaJ; Provisional; Region: PRK14277 656024000294 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 656024000295 nudix motif; other site 656024000296 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 656024000297 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 656024000298 dimer interface [polypeptide binding]; other site 656024000299 ssDNA binding site [nucleotide binding]; other site 656024000300 tetramer (dimer of dimers) interface [polypeptide binding]; other site 656024000301 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 656024000302 nucleotide binding site [chemical binding]; other site 656024000303 polymerase nucleotide-binding site; other site 656024000304 primase nucleotide-binding site [nucleotide binding]; other site 656024000305 DNA-binding residues [nucleotide binding]; DNA binding site 656024000306 Transposase, Mutator family; Region: Transposase_mut; pfam00872 656024000307 MULE transposase domain; Region: MULE; pfam10551 656024000308 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024000309 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024000310 DNA-binding interface [nucleotide binding]; DNA binding site 656024000311 putative transposase OrfB; Reviewed; Region: PHA02517 656024000312 HTH-like domain; Region: HTH_21; pfam13276 656024000313 Integrase core domain; Region: rve; pfam00665 656024000314 Integrase core domain; Region: rve_3; pfam13683 656024000315 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 656024000316 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 656024000317 NAD binding site [chemical binding]; other site 656024000318 catalytic Zn binding site [ion binding]; other site 656024000319 substrate binding site [chemical binding]; other site 656024000320 structural Zn binding site [ion binding]; other site 656024000321 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 656024000322 Cytochrome P450; Region: p450; cl12078 656024000323 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 656024000324 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 656024000325 active site 656024000326 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 656024000327 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 656024000328 DNA binding residues [nucleotide binding] 656024000329 dimerization interface [polypeptide binding]; other site 656024000330 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 656024000331 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 656024000332 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 656024000333 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 656024000334 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 656024000335 non-specific DNA binding site [nucleotide binding]; other site 656024000336 salt bridge; other site 656024000337 sequence-specific DNA binding site [nucleotide binding]; other site 656024000338 Homeodomain-like domain; Region: HTH_23; pfam13384 656024000339 Winged helix-turn helix; Region: HTH_29; pfam13551 656024000340 Homeodomain-like domain; Region: HTH_32; pfam13565 656024000341 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024000342 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 656024000343 TIR domain; Region: TIR_2; pfam13676 656024000344 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 656024000345 Protein of unknown function DUF111; Region: DUF111; cl03398 656024000346 Protein of unknown function DUF111; Region: DUF111; cl03398 656024000347 Protein of unknown function DUF111; Region: DUF111; cl03398 656024000348 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 656024000349 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 656024000350 SEC-C motif; Region: SEC-C; pfam02810 656024000351 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 656024000352 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 656024000353 putative active site [active] 656024000354 catalytic triad [active] 656024000355 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 656024000356 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 656024000357 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 656024000358 dimerization interface [polypeptide binding]; other site 656024000359 ATP binding site [chemical binding]; other site 656024000360 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 656024000361 dimerization interface [polypeptide binding]; other site 656024000362 ATP binding site [chemical binding]; other site 656024000363 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 656024000364 H+ Antiporter protein; Region: 2A0121; TIGR00900 656024000365 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 656024000366 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 656024000367 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 656024000368 DNA-binding site [nucleotide binding]; DNA binding site 656024000369 RNA-binding motif; other site 656024000370 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 656024000371 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 656024000372 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 656024000373 Ligand Binding Site [chemical binding]; other site 656024000374 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 656024000375 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 656024000376 active site residue [active] 656024000377 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 656024000378 PAS domain S-box; Region: sensory_box; TIGR00229 656024000379 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656024000380 putative active site [active] 656024000381 heme pocket [chemical binding]; other site 656024000382 PAS fold; Region: PAS_4; pfam08448 656024000383 Phosphatidylinositol-specific phospholipase C, Y domain; Region: PI-PLC-Y; cl14781 656024000384 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 656024000385 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656024000386 metal binding site [ion binding]; metal-binding site 656024000387 active site 656024000388 I-site; other site 656024000389 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 656024000390 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 656024000391 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 656024000392 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 656024000393 active site 656024000394 HIGH motif; other site 656024000395 KMSK motif region; other site 656024000396 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 656024000397 tRNA binding surface [nucleotide binding]; other site 656024000398 anticodon binding site; other site 656024000399 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 656024000400 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 656024000401 putative di-iron ligands [ion binding]; other site 656024000402 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 656024000403 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 656024000404 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 656024000405 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 656024000406 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 656024000407 phosphopeptide binding site; other site 656024000408 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 656024000409 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 656024000410 phosphopeptide binding site; other site 656024000411 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 656024000412 Protein phosphatase 2C; Region: PP2C; pfam00481 656024000413 active site 656024000414 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 656024000415 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 656024000416 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 656024000417 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 656024000418 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 656024000419 Catalytic domain of Protein Kinases; Region: PKc; cd00180 656024000420 active site 656024000421 ATP binding site [chemical binding]; other site 656024000422 substrate binding site [chemical binding]; other site 656024000423 activation loop (A-loop); other site 656024000424 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 656024000425 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 656024000426 active site 656024000427 ATP binding site [chemical binding]; other site 656024000428 substrate binding site [chemical binding]; other site 656024000429 activation loop (A-loop); other site 656024000430 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 656024000431 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 656024000432 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 656024000433 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 656024000434 Glutamine amidotransferase class-I; Region: GATase; pfam00117 656024000435 glutamine binding [chemical binding]; other site 656024000436 catalytic triad [active] 656024000437 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 656024000438 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 656024000439 acyl-activating enzyme (AAE) consensus motif; other site 656024000440 putative AMP binding site [chemical binding]; other site 656024000441 putative active site [active] 656024000442 putative CoA binding site [chemical binding]; other site 656024000443 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 656024000444 Rhomboid family; Region: Rhomboid; pfam01694 656024000445 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 656024000446 active site 656024000447 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 656024000448 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 656024000449 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 656024000450 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 656024000451 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 656024000452 DNA binding site [nucleotide binding] 656024000453 active site 656024000454 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 656024000455 Phosphotransferase enzyme family; Region: APH; pfam01636 656024000456 active site 656024000457 ATP binding site [chemical binding]; other site 656024000458 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; cl17321 656024000459 Creatinine amidohydrolase; Region: Creatininase; cl00618 656024000460 Uncharacterized conserved protein [Function unknown]; Region: COG4095 656024000461 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 656024000462 Domain of unknown function (DUF397); Region: DUF397; pfam04149 656024000463 Helix-turn-helix domain; Region: HTH_31; pfam13560 656024000464 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 656024000465 nudix motif; other site 656024000466 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 656024000467 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024000468 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024000469 DNA-binding interface [nucleotide binding]; DNA binding site 656024000470 putative transposase OrfB; Reviewed; Region: PHA02517 656024000471 HTH-like domain; Region: HTH_21; pfam13276 656024000472 Integrase core domain; Region: rve; pfam00665 656024000473 Integrase core domain; Region: rve_3; pfam13683 656024000474 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 656024000475 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 656024000476 putative ligand binding residues [chemical binding]; other site 656024000477 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 656024000478 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 656024000479 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 656024000480 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 656024000481 putative hydrophobic ligand binding site [chemical binding]; other site 656024000482 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 656024000483 dimerization interface [polypeptide binding]; other site 656024000484 putative DNA binding site [nucleotide binding]; other site 656024000485 putative Zn2+ binding site [ion binding]; other site 656024000486 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 656024000487 hypothetical protein; Provisional; Region: PRK07236 656024000488 Right handed beta helix region; Region: Beta_helix; pfam13229 656024000489 stage V sporulation protein K; Region: spore_V_K; TIGR02881 656024000490 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 656024000491 Walker A motif; other site 656024000492 ATP binding site [chemical binding]; other site 656024000493 Walker B motif; other site 656024000494 arginine finger; other site 656024000495 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 656024000496 Winged helix-turn helix; Region: HTH_29; pfam13551 656024000497 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024000498 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 656024000499 Phosphotransferase enzyme family; Region: APH; pfam01636 656024000500 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 656024000501 PQQ-like domain; Region: PQQ_2; pfam13360 656024000502 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 656024000503 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 656024000504 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 656024000505 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 656024000506 putative active site [active] 656024000507 ChaB; Region: ChaB; pfam06150 656024000508 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 656024000509 AIR carboxylase; Region: AIRC; smart01001 656024000510 prephenate dehydratase; Provisional; Region: PRK11898 656024000511 Prephenate dehydratase; Region: PDT; pfam00800 656024000512 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 656024000513 putative L-Phe binding site [chemical binding]; other site 656024000514 Vta1 like; Region: DUF605; pfam04652 656024000515 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 656024000516 Phosphotransferase enzyme family; Region: APH; pfam01636 656024000517 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 656024000518 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 656024000519 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 656024000520 dihydropteroate synthase; Region: DHPS; TIGR01496 656024000521 substrate binding pocket [chemical binding]; other site 656024000522 inhibitor binding site; inhibition site 656024000523 Dihydroneopterin aldolase; Region: FolB; smart00905 656024000524 active site 656024000525 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 656024000526 catalytic center binding site [active] 656024000527 ATP binding site [chemical binding]; other site 656024000528 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 656024000529 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 656024000530 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 656024000531 Fe-S cluster binding site [ion binding]; other site 656024000532 active site 656024000533 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 656024000534 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 656024000535 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 656024000536 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 656024000537 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 656024000538 citrate synthase 2; Provisional; Region: PRK12350 656024000539 Citrate synthase; Region: Citrate_synt; pfam00285 656024000540 oxalacetate binding site [chemical binding]; other site 656024000541 citrylCoA binding site [chemical binding]; other site 656024000542 coenzyme A binding site [chemical binding]; other site 656024000543 catalytic triad [active] 656024000544 phosphoserine aminotransferase; Provisional; Region: PRK03080 656024000545 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 656024000546 catalytic residue [active] 656024000547 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 656024000548 Citrate synthase; Region: Citrate_synt; pfam00285 656024000549 oxalacetate binding site [chemical binding]; other site 656024000550 citrylCoA binding site [chemical binding]; other site 656024000551 coenzyme A binding site [chemical binding]; other site 656024000552 catalytic triad [active] 656024000553 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 656024000554 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 656024000555 active site 656024000556 catalytic tetrad [active] 656024000557 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 656024000558 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 656024000559 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 656024000560 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 656024000561 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 656024000562 MarR family; Region: MarR; pfam01047 656024000563 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 656024000564 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 656024000565 DNA binding site [nucleotide binding] 656024000566 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 656024000567 active site 656024000568 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 656024000569 dimer interface [polypeptide binding]; other site 656024000570 non-prolyl cis peptide bond; other site 656024000571 insertion regions; other site 656024000572 Cupin domain; Region: Cupin_2; cl17218 656024000573 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 656024000574 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 656024000575 Walker A/P-loop; other site 656024000576 ATP binding site [chemical binding]; other site 656024000577 Q-loop/lid; other site 656024000578 ABC transporter signature motif; other site 656024000579 Walker B; other site 656024000580 D-loop; other site 656024000581 H-loop/switch region; other site 656024000582 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 656024000583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 656024000584 dimer interface [polypeptide binding]; other site 656024000585 conserved gate region; other site 656024000586 putative PBP binding loops; other site 656024000587 ABC-ATPase subunit interface; other site 656024000588 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 656024000589 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 656024000590 membrane-bound complex binding site; other site 656024000591 hinge residues; other site 656024000592 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 656024000593 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 656024000594 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 656024000595 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 656024000596 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 656024000597 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 656024000598 HSP90 family protein; Provisional; Region: PRK14083 656024000599 amidophosphoribosyltransferase; Provisional; Region: PRK07847 656024000600 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 656024000601 active site 656024000602 tetramer interface [polypeptide binding]; other site 656024000603 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 656024000604 active site 656024000605 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 656024000606 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 656024000607 dimerization interface [polypeptide binding]; other site 656024000608 putative ATP binding site [chemical binding]; other site 656024000609 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656024000610 metal binding site [ion binding]; metal-binding site 656024000611 active site 656024000612 I-site; other site 656024000613 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 656024000614 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 656024000615 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 656024000616 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 656024000617 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 656024000618 NAD binding site [chemical binding]; other site 656024000619 Phe binding site; other site 656024000620 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 656024000621 DNA binding residues [nucleotide binding] 656024000622 malate:quinone oxidoreductase; Validated; Region: PRK05257 656024000623 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 656024000624 Homeodomain-like domain; Region: HTH_23; pfam13384 656024000625 Winged helix-turn helix; Region: HTH_29; pfam13551 656024000626 Homeodomain-like domain; Region: HTH_32; pfam13565 656024000627 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024000628 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 656024000629 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 656024000630 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 656024000631 prevent-host-death family protein; Region: phd_fam; TIGR01552 656024000632 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 656024000633 oligomeric interface; other site 656024000634 putative active site [active] 656024000635 homodimer interface [polypeptide binding]; other site 656024000636 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 656024000637 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 656024000638 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 656024000639 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656024000640 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024000641 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 656024000642 RNA binding surface [nucleotide binding]; other site 656024000643 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 656024000644 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 656024000645 Moco binding site; other site 656024000646 metal coordination site [ion binding]; other site 656024000647 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 656024000648 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 656024000649 Ligand binding site; other site 656024000650 Putative Catalytic site; other site 656024000651 DXD motif; other site 656024000652 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 656024000653 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 656024000654 active site 656024000655 phosphorylation site [posttranslational modification] 656024000656 intermolecular recognition site; other site 656024000657 dimerization interface [polypeptide binding]; other site 656024000658 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 656024000659 DNA binding site [nucleotide binding] 656024000660 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 656024000661 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 656024000662 phosphorylation site [posttranslational modification] 656024000663 dimer interface [polypeptide binding]; other site 656024000664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656024000665 ATP binding site [chemical binding]; other site 656024000666 Mg2+ binding site [ion binding]; other site 656024000667 G-X-G motif; other site 656024000668 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 656024000669 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656024000670 NAD(P) binding site [chemical binding]; other site 656024000671 active site 656024000672 probable F420-dependent oxidoreductase, MSMEG_3544 family; Region: F420_MSMEG_3544; TIGR03854 656024000673 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 656024000674 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 656024000675 Cytochrome P450; Region: p450; cl12078 656024000676 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 656024000677 Subunit I/III interface [polypeptide binding]; other site 656024000678 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 656024000679 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 656024000680 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 656024000681 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 656024000682 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 656024000683 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 656024000684 Carboxylesterase family; Region: COesterase; pfam00135 656024000685 substrate binding pocket [chemical binding]; other site 656024000686 catalytic triad [active] 656024000687 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 656024000688 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 656024000689 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024000690 Walker A/P-loop; other site 656024000691 ATP binding site [chemical binding]; other site 656024000692 Q-loop/lid; other site 656024000693 ABC transporter signature motif; other site 656024000694 Walker B; other site 656024000695 D-loop; other site 656024000696 H-loop/switch region; other site 656024000697 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 656024000698 Int/Topo IB signature motif; other site 656024000699 Helix-turn-helix domain; Region: HTH_17; pfam12728 656024000700 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 656024000701 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 656024000702 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 656024000703 DNA-binding site [nucleotide binding]; DNA binding site 656024000704 UTRA domain; Region: UTRA; pfam07702 656024000705 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 656024000706 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 656024000707 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 656024000708 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 656024000709 putative transposase OrfB; Reviewed; Region: PHA02517 656024000710 HTH-like domain; Region: HTH_21; pfam13276 656024000711 Integrase core domain; Region: rve; pfam00665 656024000712 Integrase core domain; Region: rve_3; pfam13683 656024000713 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024000714 Transposase; Region: HTH_Tnp_1; pfam01527 656024000715 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 656024000716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024000717 Major Facilitator Superfamily; Region: MFS_1; pfam07690 656024000718 Hemerythrin-like domain; Region: Hr-like; cd12108 656024000719 Fe binding site [ion binding]; other site 656024000720 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 656024000721 NADH(P)-binding; Region: NAD_binding_10; pfam13460 656024000722 NAD binding site [chemical binding]; other site 656024000723 substrate binding site [chemical binding]; other site 656024000724 putative active site [active] 656024000725 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 656024000726 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 656024000727 conserved cys residue [active] 656024000728 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 656024000729 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 656024000730 NAD(P) binding site [chemical binding]; other site 656024000731 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 656024000732 AAA domain; Region: AAA_33; pfam13671 656024000733 AAA domain; Region: AAA_17; pfam13207 656024000734 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 656024000735 Catalytic domain of Protein Kinases; Region: PKc; cd00180 656024000736 active site 656024000737 ATP binding site [chemical binding]; other site 656024000738 substrate binding site [chemical binding]; other site 656024000739 activation loop (A-loop); other site 656024000740 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 656024000741 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 656024000742 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 656024000743 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 656024000744 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cl17565 656024000745 putative metal binding site [ion binding]; other site 656024000746 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 656024000747 catalytic site [active] 656024000748 active site 656024000749 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 656024000750 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 656024000751 active site 2 [active] 656024000752 active site 1 [active] 656024000753 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 656024000754 CoenzymeA binding site [chemical binding]; other site 656024000755 subunit interaction site [polypeptide binding]; other site 656024000756 PHB binding site; other site 656024000757 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 656024000758 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 656024000759 substrate binding site [chemical binding]; other site 656024000760 oxyanion hole (OAH) forming residues; other site 656024000761 trimer interface [polypeptide binding]; other site 656024000762 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656024000763 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024000764 YDG/SRA domain; Region: YDG_SRA; cl02620 656024000765 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 656024000766 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 656024000767 acyl-activating enzyme (AAE) consensus motif; other site 656024000768 putative AMP binding site [chemical binding]; other site 656024000769 putative active site [active] 656024000770 putative CoA binding site [chemical binding]; other site 656024000771 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 656024000772 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 656024000773 substrate binding site [chemical binding]; other site 656024000774 oxyanion hole (OAH) forming residues; other site 656024000775 trimer interface [polypeptide binding]; other site 656024000776 AAA ATPase domain; Region: AAA_16; pfam13191 656024000777 Homeodomain-like domain; Region: HTH_23; pfam13384 656024000778 Winged helix-turn helix; Region: HTH_29; pfam13551 656024000779 Homeodomain-like domain; Region: HTH_32; pfam13565 656024000780 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024000781 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 656024000782 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861 656024000783 TM2 domain; Region: TM2; pfam05154 656024000784 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 656024000785 Protein of unknown function (DUF4243); Region: DUF4243; pfam14027 656024000786 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 656024000787 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 656024000788 putative Zn2+ binding site [ion binding]; other site 656024000789 putative DNA binding site [nucleotide binding]; other site 656024000790 enterobactin exporter EntS; Provisional; Region: PRK10489 656024000791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024000792 putative substrate translocation pore; other site 656024000793 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 656024000794 hypothetical protein; Provisional; Region: PRK11770 656024000795 Domain of unknown function (DUF307); Region: DUF307; pfam03733 656024000796 Epoxide hydrolase N terminus; Region: EHN; pfam06441 656024000797 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 656024000798 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 656024000799 Post-segregation antitoxin CcdA; Region: CcdA; cl02188 656024000800 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 656024000801 Catalytic domain of Protein Kinases; Region: PKc; cd00180 656024000802 active site 656024000803 ATP binding site [chemical binding]; other site 656024000804 substrate binding site [chemical binding]; other site 656024000805 activation loop (A-loop); other site 656024000806 von Hippel-Landau (pVHL) tumor suppressor protein; Region: pVHL; cl03381 656024000807 pVHL-HIF-1alpha interaction [polypeptide binding]; other site 656024000808 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 656024000809 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 656024000810 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 656024000811 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 656024000812 dimer interface [polypeptide binding]; other site 656024000813 conserved gate region; other site 656024000814 putative PBP binding loops; other site 656024000815 ABC-ATPase subunit interface; other site 656024000816 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 656024000817 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 656024000818 Walker A/P-loop; other site 656024000819 ATP binding site [chemical binding]; other site 656024000820 Q-loop/lid; other site 656024000821 ABC transporter signature motif; other site 656024000822 Walker B; other site 656024000823 D-loop; other site 656024000824 H-loop/switch region; other site 656024000825 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 656024000826 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 656024000827 Walker A/P-loop; other site 656024000828 ATP binding site [chemical binding]; other site 656024000829 Q-loop/lid; other site 656024000830 ABC transporter signature motif; other site 656024000831 Walker B; other site 656024000832 D-loop; other site 656024000833 H-loop/switch region; other site 656024000834 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 656024000835 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 656024000836 active site 656024000837 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 656024000838 non-prolyl cis peptide bond; other site 656024000839 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 656024000840 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 656024000841 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 656024000842 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 656024000843 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 656024000844 Coenzyme A binding pocket [chemical binding]; other site 656024000845 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 656024000846 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 656024000847 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 656024000848 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024000849 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024000850 DNA-binding interface [nucleotide binding]; DNA binding site 656024000851 putative transposase OrfB; Reviewed; Region: PHA02517 656024000852 HTH-like domain; Region: HTH_21; pfam13276 656024000853 Integrase core domain; Region: rve; pfam00665 656024000854 Integrase core domain; Region: rve_3; pfam13683 656024000855 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 656024000856 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 656024000857 active site 656024000858 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 656024000859 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 656024000860 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 656024000861 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 656024000862 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 656024000863 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 656024000864 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 656024000865 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 656024000866 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 656024000867 Helix-turn-helix domain; Region: HTH_17; pfam12728 656024000868 Frankia-40 domain; Region: Frankia_40_dom; TIGR03917 656024000869 Transcriptional regulators [Transcription]; Region: FadR; COG2186 656024000870 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 656024000871 DNA-binding site [nucleotide binding]; DNA binding site 656024000872 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 656024000873 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 656024000874 MarR family; Region: MarR_2; pfam12802 656024000875 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 656024000876 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 656024000877 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 656024000878 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 656024000879 Cytochrome P450; Region: p450; cl12078 656024000880 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 656024000881 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 656024000882 Cytochrome P450; Region: p450; cl12078 656024000883 hypothetical protein; Provisional; Region: PRK07877 656024000884 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 656024000885 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 656024000886 active site 656024000887 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 656024000888 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 656024000889 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 656024000890 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 656024000891 substrate-cofactor binding pocket; other site 656024000892 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656024000893 catalytic residue [active] 656024000894 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 656024000895 NifU-like domain; Region: NifU; cl00484 656024000896 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 656024000897 iron-sulfur cluster [ion binding]; other site 656024000898 [2Fe-2S] cluster binding site [ion binding]; other site 656024000899 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 656024000900 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 656024000901 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 656024000902 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 656024000903 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 656024000904 DXD motif; other site 656024000905 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 656024000906 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024000907 Walker A/P-loop; other site 656024000908 ATP binding site [chemical binding]; other site 656024000909 Q-loop/lid; other site 656024000910 ABC transporter signature motif; other site 656024000911 Walker B; other site 656024000912 D-loop; other site 656024000913 H-loop/switch region; other site 656024000914 TOBE domain; Region: TOBE_2; pfam08402 656024000915 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 656024000916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 656024000917 dimer interface [polypeptide binding]; other site 656024000918 conserved gate region; other site 656024000919 putative PBP binding loops; other site 656024000920 ABC-ATPase subunit interface; other site 656024000921 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 656024000922 dimer interface [polypeptide binding]; other site 656024000923 conserved gate region; other site 656024000924 ABC-ATPase subunit interface; other site 656024000925 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 656024000926 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 656024000927 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 656024000928 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 656024000929 CoA binding site [chemical binding]; other site 656024000930 active site 656024000931 AMP binding site [chemical binding]; other site 656024000932 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 656024000933 Acyltransferase family; Region: Acyl_transf_3; pfam01757 656024000934 MG2 domain; Region: A2M_N; pfam01835 656024000935 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 656024000936 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 656024000937 Catalytic domain of Protein Kinases; Region: PKc; cd00180 656024000938 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 656024000939 active site 656024000940 ATP binding site [chemical binding]; other site 656024000941 substrate binding site [chemical binding]; other site 656024000942 activation loop (A-loop); other site 656024000943 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 656024000944 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 656024000945 Cupin domain; Region: Cupin_2; cl17218 656024000946 Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229 656024000947 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 656024000948 motif I; other site 656024000949 motif II; other site 656024000950 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 656024000951 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 656024000952 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 656024000953 S-adenosylmethionine synthetase; Validated; Region: PRK05250 656024000954 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 656024000955 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 656024000956 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 656024000957 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 656024000958 TIGR03086 family protein; Region: TIGR03086 656024000959 Winged helix-turn helix; Region: HTH_29; pfam13551 656024000960 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024000961 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 656024000962 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 656024000963 putative active site [active] 656024000964 putative metal binding site [ion binding]; other site 656024000965 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 656024000966 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024000967 Transposase; Region: HTH_Tnp_1; pfam01527 656024000968 putative transposase OrfB; Reviewed; Region: PHA02517 656024000969 HTH-like domain; Region: HTH_21; pfam13276 656024000970 Integrase core domain; Region: rve; pfam00665 656024000971 Integrase core domain; Region: rve_3; pfam13683 656024000972 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 656024000973 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 656024000974 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 656024000975 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 656024000976 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 656024000977 catalytic residue [active] 656024000978 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 656024000979 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 656024000980 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 656024000981 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 656024000982 putative active site [active] 656024000983 catalytic triad [active] 656024000984 putative dimer interface [polypeptide binding]; other site 656024000985 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 656024000986 hydrophobic ligand binding site; other site 656024000987 Uncharacterized membrane protein, required for N-linked glycosylation [General function prediction only]; Region: COG1287 656024000988 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 656024000989 RNase_H superfamily; Region: RNase_H_2; pfam13482 656024000990 Part of AAA domain; Region: AAA_19; pfam13245 656024000991 AAA domain; Region: AAA_11; pfam13086 656024000992 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 656024000993 AAA domain; Region: AAA_12; pfam13087 656024000994 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 656024000995 putative active site [active] 656024000996 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 656024000997 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 656024000998 phosphopeptide binding site; other site 656024000999 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024001000 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 656024001001 Walker A/P-loop; other site 656024001002 ATP binding site [chemical binding]; other site 656024001003 Q-loop/lid; other site 656024001004 ABC transporter signature motif; other site 656024001005 Walker B; other site 656024001006 D-loop; other site 656024001007 H-loop/switch region; other site 656024001008 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 656024001009 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 656024001010 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 656024001011 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 656024001012 P-loop; other site 656024001013 Magnesium ion binding site [ion binding]; other site 656024001014 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 656024001015 Magnesium ion binding site [ion binding]; other site 656024001016 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 656024001017 nudix motif; other site 656024001018 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 656024001019 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 656024001020 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 656024001021 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 656024001022 Homeodomain-like domain; Region: HTH_23; pfam13384 656024001023 Winged helix-turn helix; Region: HTH_29; pfam13551 656024001024 Homeodomain-like domain; Region: HTH_32; pfam13565 656024001025 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024001026 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 656024001027 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 656024001028 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 656024001029 active site 656024001030 metal binding site [ion binding]; metal-binding site 656024001031 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 656024001032 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 656024001033 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 656024001034 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 656024001035 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 656024001036 ligand binding site; other site 656024001037 oligomer interface; other site 656024001038 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 656024001039 dimer interface [polypeptide binding]; other site 656024001040 N-terminal domain interface [polypeptide binding]; other site 656024001041 sulfate 1 binding site; other site 656024001042 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 656024001043 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 656024001044 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 656024001045 S-adenosylmethionine binding site [chemical binding]; other site 656024001046 Winged helix-turn helix; Region: HTH_29; pfam13551 656024001047 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024001048 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 656024001049 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 656024001050 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 656024001051 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 656024001052 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 656024001053 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 656024001054 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 656024001055 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 656024001056 active site 656024001057 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 656024001058 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 656024001059 dimer interface [polypeptide binding]; other site 656024001060 active site 656024001061 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 656024001062 N-terminal aromatase/cyclase domain of the multifunctional protein tetracenomycin (TcmN) and related domains; Region: TcmN_ARO-CYC_like; cd08860 656024001063 putative hydrophobic ligand binding site [chemical binding]; other site 656024001064 active site 656024001065 catalytic residues_2 [active] 656024001066 catalytic residues_1 [active] 656024001067 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 656024001068 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673 656024001069 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 656024001070 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 656024001071 dimerization interface [polypeptide binding]; other site 656024001072 DNA binding residues [nucleotide binding] 656024001073 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 656024001074 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 656024001075 G2 box; other site 656024001076 Switch I region; other site 656024001077 G3 box; other site 656024001078 Switch II region; other site 656024001079 GTP/Mg2+ binding site [chemical binding]; other site 656024001080 G4 box; other site 656024001081 G5 box; other site 656024001082 Protein of unknown function (DUF742); Region: DUF742; pfam05331 656024001083 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 656024001084 Nitrate and nitrite sensing; Region: NIT; pfam08376 656024001085 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 656024001086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656024001087 ATP binding site [chemical binding]; other site 656024001088 Mg2+ binding site [ion binding]; other site 656024001089 G-X-G motif; other site 656024001090 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 656024001091 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 656024001092 active site 656024001093 ATP binding site [chemical binding]; other site 656024001094 substrate binding site [chemical binding]; other site 656024001095 activation loop (A-loop); other site 656024001096 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 656024001097 ABC-2 type transporter; Region: ABC2_membrane; cl17235 656024001098 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 656024001099 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 656024001100 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 656024001101 Walker A/P-loop; other site 656024001102 ATP binding site [chemical binding]; other site 656024001103 Q-loop/lid; other site 656024001104 ABC transporter signature motif; other site 656024001105 Walker B; other site 656024001106 D-loop; other site 656024001107 H-loop/switch region; other site 656024001108 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 656024001109 S-adenosylmethionine binding site [chemical binding]; other site 656024001110 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 656024001111 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 656024001112 radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269 656024001113 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 656024001114 FeS/SAM binding site; other site 656024001115 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 656024001116 Cupin domain; Region: Cupin_2; pfam07883 656024001117 N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510 656024001118 amidase catalytic site [active] 656024001119 Zn binding residues [ion binding]; other site 656024001120 substrate binding site [chemical binding]; other site 656024001121 RyR domain; Region: RyR; pfam02026 656024001122 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 656024001123 phosphate binding site [ion binding]; other site 656024001124 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 656024001125 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 656024001126 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 656024001127 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 656024001128 active site 656024001129 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 656024001130 N-acetyl-D-glucosamine binding site [chemical binding]; other site 656024001131 catalytic residue [active] 656024001132 Protein kinase domain; Region: Pkinase; pfam00069 656024001133 Catalytic domain of Protein Kinases; Region: PKc; cd00180 656024001134 active site 656024001135 ATP binding site [chemical binding]; other site 656024001136 substrate binding site [chemical binding]; other site 656024001137 activation loop (A-loop); other site 656024001138 FOG: WD40 repeat [General function prediction only]; Region: COG2319 656024001139 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 656024001140 structural tetrad; other site 656024001141 ANTAR domain; Region: ANTAR; pfam03861 656024001142 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 656024001143 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 656024001144 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 656024001145 dimerization interface [polypeptide binding]; other site 656024001146 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 656024001147 dimerization interface [polypeptide binding]; other site 656024001148 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 656024001149 dimerization interface [polypeptide binding]; other site 656024001150 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 656024001151 dimerization interface [polypeptide binding]; other site 656024001152 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 656024001153 GAF domain; Region: GAF; pfam01590 656024001154 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 656024001155 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656024001156 ATP binding site [chemical binding]; other site 656024001157 Mg2+ binding site [ion binding]; other site 656024001158 G-X-G motif; other site 656024001159 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 656024001160 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 656024001161 active site 656024001162 phosphorylation site [posttranslational modification] 656024001163 intermolecular recognition site; other site 656024001164 dimerization interface [polypeptide binding]; other site 656024001165 PBP superfamily domain; Region: PBP_like_2; cl17296 656024001166 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 656024001167 dimerization interface [polypeptide binding]; other site 656024001168 putative DNA binding site [nucleotide binding]; other site 656024001169 putative Zn2+ binding site [ion binding]; other site 656024001170 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 656024001171 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 656024001172 active site 656024001173 metal binding site [ion binding]; metal-binding site 656024001174 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 656024001175 amphipathic channel; other site 656024001176 Asn-Pro-Ala signature motifs; other site 656024001177 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 656024001178 Low molecular weight phosphatase family; Region: LMWPc; cd00115 656024001179 active site 656024001180 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 656024001181 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 656024001182 DNA binding residues [nucleotide binding] 656024001183 dimerization interface [polypeptide binding]; other site 656024001184 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 656024001185 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 656024001186 DNA binding residues [nucleotide binding] 656024001187 dimerization interface [polypeptide binding]; other site 656024001188 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024001189 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024001190 DNA-binding interface [nucleotide binding]; DNA binding site 656024001191 putative transposase OrfB; Reviewed; Region: PHA02517 656024001192 HTH-like domain; Region: HTH_21; pfam13276 656024001193 Integrase core domain; Region: rve; pfam00665 656024001194 Integrase core domain; Region: rve_3; pfam13683 656024001195 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 656024001196 salt bridge; other site 656024001197 non-specific DNA binding site [nucleotide binding]; other site 656024001198 sequence-specific DNA binding site [nucleotide binding]; other site 656024001199 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 656024001200 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 656024001201 dimerization interface [polypeptide binding]; other site 656024001202 putative DNA binding site [nucleotide binding]; other site 656024001203 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 656024001204 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 656024001205 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 656024001206 Predicted esterase [General function prediction only]; Region: COG0627 656024001207 S-formylglutathione hydrolase; Region: PLN02442 656024001208 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 656024001209 Lipase (class 2); Region: Lipase_2; pfam01674 656024001210 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 656024001211 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 656024001212 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 656024001213 DNA binding residues [nucleotide binding] 656024001214 Homeodomain-like domain; Region: HTH_23; pfam13384 656024001215 Winged helix-turn helix; Region: HTH_29; pfam13551 656024001216 Homeodomain-like domain; Region: HTH_32; pfam13565 656024001217 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024001218 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 656024001219 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 656024001220 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 656024001221 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 656024001222 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 656024001223 non-specific DNA binding site [nucleotide binding]; other site 656024001224 salt bridge; other site 656024001225 sequence-specific DNA binding site [nucleotide binding]; other site 656024001226 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 656024001227 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 656024001228 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 656024001229 active site 656024001230 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 656024001231 Divergent AAA domain; Region: AAA_4; pfam04326 656024001232 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 656024001233 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 656024001234 Peptidase family M48; Region: Peptidase_M48; cl12018 656024001235 Penicillinase repressor; Region: Pencillinase_R; cl17580 656024001236 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 656024001237 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 656024001238 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 656024001239 CAAX protease self-immunity; Region: Abi; pfam02517 656024001240 Uncharacterized conserved protein [Function unknown]; Region: COG3025 656024001241 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 656024001242 putative active site; other site 656024001243 putative metal binding residues [ion binding]; other site 656024001244 signature motif; other site 656024001245 putative triphosphate binding site [ion binding]; other site 656024001246 CHAD domain; Region: CHAD; pfam05235 656024001247 Helix-turn-helix domain; Region: HTH_31; pfam13560 656024001248 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 656024001249 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 656024001250 active site 656024001251 phosphorylation site [posttranslational modification] 656024001252 intermolecular recognition site; other site 656024001253 dimerization interface [polypeptide binding]; other site 656024001254 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 656024001255 DNA binding site [nucleotide binding] 656024001256 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 656024001257 HAMP domain; Region: HAMP; pfam00672 656024001258 dimerization interface [polypeptide binding]; other site 656024001259 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 656024001260 dimer interface [polypeptide binding]; other site 656024001261 phosphorylation site [posttranslational modification] 656024001262 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656024001263 ATP binding site [chemical binding]; other site 656024001264 Mg2+ binding site [ion binding]; other site 656024001265 G-X-G motif; other site 656024001266 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 656024001267 Sulfatase; Region: Sulfatase; pfam00884 656024001268 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 656024001269 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 656024001270 active site 656024001271 catalytic tetrad [active] 656024001272 Methyltransferase domain; Region: Methyltransf_26; pfam13659 656024001273 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 656024001274 DNA-binding site [nucleotide binding]; DNA binding site 656024001275 RNA-binding motif; other site 656024001276 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 656024001277 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 656024001278 aspartate kinase; Reviewed; Region: PRK06635 656024001279 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 656024001280 putative nucleotide binding site [chemical binding]; other site 656024001281 putative catalytic residues [active] 656024001282 putative Mg ion binding site [ion binding]; other site 656024001283 putative aspartate binding site [chemical binding]; other site 656024001284 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 656024001285 putative allosteric regulatory site; other site 656024001286 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 656024001287 putative allosteric regulatory residue; other site 656024001288 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 656024001289 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 656024001290 putative metal binding site [ion binding]; other site 656024001291 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 656024001292 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 656024001293 NAD(P) binding site [chemical binding]; other site 656024001294 Fic family protein [Function unknown]; Region: COG3177 656024001295 Fic/DOC family; Region: Fic; pfam02661 656024001296 recombination protein RecR; Reviewed; Region: recR; PRK00076 656024001297 Helix-hairpin-helix motif; Region: HHH; pfam00633 656024001298 RecR protein; Region: RecR; pfam02132 656024001299 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 656024001300 putative active site [active] 656024001301 putative metal-binding site [ion binding]; other site 656024001302 tetramer interface [polypeptide binding]; other site 656024001303 hypothetical protein; Validated; Region: PRK00153 656024001304 TIR domain; Region: TIR_2; pfam13676 656024001305 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 656024001306 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 656024001307 FOG: WD40 repeat [General function prediction only]; Region: COG2319 656024001308 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 656024001309 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 656024001310 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 656024001311 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 656024001312 Walker A motif; other site 656024001313 ATP binding site [chemical binding]; other site 656024001314 Walker B motif; other site 656024001315 arginine finger; other site 656024001316 Archaeal ATPase; Region: Arch_ATPase; pfam01637 656024001317 AAA ATPase domain; Region: AAA_16; pfam13191 656024001318 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 656024001319 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 656024001320 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 656024001321 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 656024001322 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 656024001323 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 656024001324 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 656024001325 active site 656024001326 intersubunit interface [polypeptide binding]; other site 656024001327 zinc binding site [ion binding]; other site 656024001328 Na+ binding site [ion binding]; other site 656024001329 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 656024001330 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 656024001331 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 656024001332 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656024001333 NAD(P) binding site [chemical binding]; other site 656024001334 active site 656024001335 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 656024001336 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 656024001337 active site 656024001338 NTP binding site [chemical binding]; other site 656024001339 metal binding triad [ion binding]; metal-binding site 656024001340 MMPL family; Region: MMPL; pfam03176 656024001341 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 656024001342 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 656024001343 Clp amino terminal domain; Region: Clp_N; pfam02861 656024001344 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 656024001345 Walker A motif; other site 656024001346 ATP binding site [chemical binding]; other site 656024001347 Walker B motif; other site 656024001348 arginine finger; other site 656024001349 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 656024001350 Walker A motif; other site 656024001351 ATP binding site [chemical binding]; other site 656024001352 Walker B motif; other site 656024001353 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 656024001354 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 656024001355 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 656024001356 DNA binding residues [nucleotide binding] 656024001357 putative dimer interface [polypeptide binding]; other site 656024001358 chaperone protein DnaJ; Provisional; Region: PRK14295 656024001359 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 656024001360 HSP70 interaction site [polypeptide binding]; other site 656024001361 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 656024001362 Zn binding sites [ion binding]; other site 656024001363 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 656024001364 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 656024001365 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 656024001366 dimer interface [polypeptide binding]; other site 656024001367 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 656024001368 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 656024001369 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 656024001370 nucleotide binding site [chemical binding]; other site 656024001371 NEF interaction site [polypeptide binding]; other site 656024001372 SBD interface [polypeptide binding]; other site 656024001373 Nuclease-related domain; Region: NERD; pfam08378 656024001374 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 656024001375 4Fe-4S binding domain; Region: Fer4; cl02805 656024001376 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 656024001377 4Fe-4S binding domain; Region: Fer4; pfam00037 656024001378 Cysteine-rich domain; Region: CCG; pfam02754 656024001379 Cysteine-rich domain; Region: CCG; pfam02754 656024001380 Uncharacterized conserved protein [Function unknown]; Region: COG2898 656024001381 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 656024001382 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 656024001383 haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1 656024001384 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 656024001385 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 656024001386 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 656024001387 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 656024001388 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 656024001389 trimer interface [polypeptide binding]; other site 656024001390 active site 656024001391 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 656024001392 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 656024001393 oligomeric interface; other site 656024001394 putative active site [active] 656024001395 homodimer interface [polypeptide binding]; other site 656024001396 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 656024001397 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 656024001398 classical (c) SDRs; Region: SDR_c; cd05233 656024001399 NAD(P) binding site [chemical binding]; other site 656024001400 active site 656024001401 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 656024001402 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 656024001403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656024001404 homodimer interface [polypeptide binding]; other site 656024001405 catalytic residue [active] 656024001406 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 656024001407 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 656024001408 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 656024001409 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 656024001410 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 656024001411 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 656024001412 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 656024001413 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 656024001414 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 656024001415 metal-binding site 656024001416 DivIVA domain; Region: DivI1A_domain; TIGR03544 656024001417 DivIVA domain; Region: DivI1A_domain; TIGR03544 656024001418 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 656024001419 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 656024001420 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 656024001421 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 656024001422 oligomer interface [polypeptide binding]; other site 656024001423 metal binding site [ion binding]; metal-binding site 656024001424 metal binding site [ion binding]; metal-binding site 656024001425 putative Cl binding site [ion binding]; other site 656024001426 basic sphincter; other site 656024001427 hydrophobic gate; other site 656024001428 periplasmic entrance; other site 656024001429 Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have...; Region: ZZ; cl00295 656024001430 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 656024001431 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 656024001432 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 656024001433 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 656024001434 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 656024001435 NAD binding site [chemical binding]; other site 656024001436 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 656024001437 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 656024001438 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 656024001439 Hyaluronan synthases catalyze polymerization of hyaluronan; Region: GT2_HAS; cd06434 656024001440 DXD motif; other site 656024001441 Right handed beta helix region; Region: Beta_helix; pfam13229 656024001442 Right handed beta helix region; Region: Beta_helix; pfam13229 656024001443 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 656024001444 integral membrane protein; Region: integ_memb_HG; TIGR03954 656024001445 Glucitol operon activator protein (GutM); Region: GutM; cl01890 656024001446 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 656024001447 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 656024001448 DNA binding residues [nucleotide binding] 656024001449 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 656024001450 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 656024001451 NAD(P) binding site [chemical binding]; other site 656024001452 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 656024001453 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 656024001454 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 656024001455 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 656024001456 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 656024001457 active site 656024001458 motif I; other site 656024001459 motif II; other site 656024001460 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 656024001461 homodimer interface [polypeptide binding]; other site 656024001462 putative metal binding site [ion binding]; other site 656024001463 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 656024001464 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 656024001465 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 656024001466 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 656024001467 homodecamer interface [polypeptide binding]; other site 656024001468 GTP cyclohydrolase I; Provisional; Region: PLN03044 656024001469 active site 656024001470 putative catalytic site residues [active] 656024001471 zinc binding site [ion binding]; other site 656024001472 GTP-CH-I/GFRP interaction surface; other site 656024001473 FtsH Extracellular; Region: FtsH_ext; pfam06480 656024001474 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 656024001475 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 656024001476 Walker A motif; other site 656024001477 ATP binding site [chemical binding]; other site 656024001478 Walker B motif; other site 656024001479 arginine finger; other site 656024001480 Peptidase family M41; Region: Peptidase_M41; pfam01434 656024001481 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 656024001482 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 656024001483 Ligand Binding Site [chemical binding]; other site 656024001484 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 656024001485 active site 656024001486 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 656024001487 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 656024001488 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 656024001489 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 656024001490 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 656024001491 dimer interface [polypeptide binding]; other site 656024001492 substrate binding site [chemical binding]; other site 656024001493 metal binding sites [ion binding]; metal-binding site 656024001494 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 656024001495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 656024001496 active site 656024001497 phosphorylation site [posttranslational modification] 656024001498 intermolecular recognition site; other site 656024001499 dimerization interface [polypeptide binding]; other site 656024001500 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 656024001501 DNA binding site [nucleotide binding] 656024001502 Homeodomain-like domain; Region: HTH_23; pfam13384 656024001503 Winged helix-turn helix; Region: HTH_29; pfam13551 656024001504 Homeodomain-like domain; Region: HTH_32; pfam13565 656024001505 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024001506 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 656024001507 PSP1 C-terminal conserved region; Region: PSP1; cl00770 656024001508 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 656024001509 Catalytic domain of Protein Kinases; Region: PKc; cd00180 656024001510 active site 656024001511 ATP binding site [chemical binding]; other site 656024001512 substrate binding site [chemical binding]; other site 656024001513 activation loop (A-loop); other site 656024001514 Predicted transcriptional regulators [Transcription]; Region: COG1695 656024001515 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 656024001516 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 656024001517 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 656024001518 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 656024001519 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 656024001520 Walker A/P-loop; other site 656024001521 ATP binding site [chemical binding]; other site 656024001522 Q-loop/lid; other site 656024001523 ABC transporter signature motif; other site 656024001524 Walker B; other site 656024001525 D-loop; other site 656024001526 H-loop/switch region; other site 656024001527 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 656024001528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 656024001529 dimer interface [polypeptide binding]; other site 656024001530 conserved gate region; other site 656024001531 putative PBP binding loops; other site 656024001532 ABC-ATPase subunit interface; other site 656024001533 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 656024001534 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 656024001535 active site 656024001536 non-prolyl cis peptide bond; other site 656024001537 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 656024001538 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 656024001539 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 656024001540 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 656024001541 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 656024001542 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 656024001543 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 656024001544 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 656024001545 active site 656024001546 catalytic site [active] 656024001547 glycine dehydrogenase; Provisional; Region: PRK05367 656024001548 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 656024001549 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 656024001550 catalytic residue [active] 656024001551 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 656024001552 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 656024001553 catalytic residue [active] 656024001554 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 656024001555 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 656024001556 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 656024001557 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656024001558 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024001559 MMPL family; Region: MMPL; pfam03176 656024001560 MMPL family; Region: MMPL; pfam03176 656024001561 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 656024001562 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 656024001563 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 656024001564 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 656024001565 IucA / IucC family; Region: IucA_IucC; pfam04183 656024001566 IucA / IucC family; Region: IucA_IucC; pfam04183 656024001567 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 656024001568 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 656024001569 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 656024001570 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 656024001571 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 656024001572 inhibitor-cofactor binding pocket; inhibition site 656024001573 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656024001574 catalytic residue [active] 656024001575 cystathionine gamma-synthase; Provisional; Region: PRK07811 656024001576 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 656024001577 homodimer interface [polypeptide binding]; other site 656024001578 substrate-cofactor binding pocket; other site 656024001579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656024001580 catalytic residue [active] 656024001581 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 656024001582 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 656024001583 dimer interface [polypeptide binding]; other site 656024001584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656024001585 catalytic residue [active] 656024001586 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 656024001587 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 656024001588 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 656024001589 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 656024001590 catalytic residue [active] 656024001591 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 656024001592 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 656024001593 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 656024001594 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 656024001595 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 656024001596 dimerization interface [polypeptide binding]; other site 656024001597 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 656024001598 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 656024001599 dimerization interface [polypeptide binding]; other site 656024001600 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 656024001601 dimerization interface [polypeptide binding]; other site 656024001602 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 656024001603 dimerization interface [polypeptide binding]; other site 656024001604 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 656024001605 dimerization interface [polypeptide binding]; other site 656024001606 GAF domain; Region: GAF_2; pfam13185 656024001607 GAF domain; Region: GAF_3; pfam13492 656024001608 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 656024001609 dimer interface [polypeptide binding]; other site 656024001610 phosphorylation site [posttranslational modification] 656024001611 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656024001612 ATP binding site [chemical binding]; other site 656024001613 Mg2+ binding site [ion binding]; other site 656024001614 G-X-G motif; other site 656024001615 Response regulator receiver domain; Region: Response_reg; pfam00072 656024001616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 656024001617 active site 656024001618 phosphorylation site [posttranslational modification] 656024001619 intermolecular recognition site; other site 656024001620 dimerization interface [polypeptide binding]; other site 656024001621 Response regulator receiver domain; Region: Response_reg; pfam00072 656024001622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 656024001623 active site 656024001624 phosphorylation site [posttranslational modification] 656024001625 intermolecular recognition site; other site 656024001626 dimerization interface [polypeptide binding]; other site 656024001627 Domain of unknown function (DUF305); Region: DUF305; pfam03713 656024001628 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 656024001629 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 656024001630 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 656024001631 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 656024001632 Ligand binding site; other site 656024001633 Putative Catalytic site; other site 656024001634 DXD motif; other site 656024001635 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 656024001636 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 656024001637 Predicted methyltransferases [General function prediction only]; Region: COG0313 656024001638 putative SAM binding site [chemical binding]; other site 656024001639 putative homodimer interface [polypeptide binding]; other site 656024001640 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 656024001641 putative active site [active] 656024001642 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 656024001643 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 656024001644 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 656024001645 active site 656024001646 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 656024001647 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 656024001648 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 656024001649 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 656024001650 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 656024001651 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 656024001652 ABC transporter; Region: ABC_tran_2; pfam12848 656024001653 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 656024001654 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 656024001655 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 656024001656 Fatty acid desaturase; Region: FA_desaturase; pfam00487 656024001657 Di-iron ligands [ion binding]; other site 656024001658 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 656024001659 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 656024001660 Substrate binding site; other site 656024001661 Mg++ binding site; other site 656024001662 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 656024001663 active site 656024001664 substrate binding site [chemical binding]; other site 656024001665 CoA binding site [chemical binding]; other site 656024001666 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 656024001667 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 656024001668 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 656024001669 active site 656024001670 hypothetical protein; Provisional; Region: PRK02237 656024001671 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 656024001672 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 656024001673 5S rRNA interface [nucleotide binding]; other site 656024001674 CTC domain interface [polypeptide binding]; other site 656024001675 L16 interface [polypeptide binding]; other site 656024001676 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 656024001677 putative active site [active] 656024001678 catalytic residue [active] 656024001679 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 656024001680 Methyltransferase domain; Region: Methyltransf_23; pfam13489 656024001681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 656024001682 S-adenosylmethionine binding site [chemical binding]; other site 656024001683 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 656024001684 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 656024001685 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 656024001686 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 656024001687 ATP binding site [chemical binding]; other site 656024001688 putative Mg++ binding site [ion binding]; other site 656024001689 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 656024001690 nucleotide binding region [chemical binding]; other site 656024001691 ATP-binding site [chemical binding]; other site 656024001692 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 656024001693 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 656024001694 homodimer interface [polypeptide binding]; other site 656024001695 metal binding site [ion binding]; metal-binding site 656024001696 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 656024001697 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 656024001698 homodimer interface [polypeptide binding]; other site 656024001699 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 656024001700 tandem repeat interface [polypeptide binding]; other site 656024001701 oligomer interface [polypeptide binding]; other site 656024001702 active site residues [active] 656024001703 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 656024001704 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 656024001705 oligomer interface [polypeptide binding]; other site 656024001706 tandem repeat interface [polypeptide binding]; other site 656024001707 active site residues [active] 656024001708 enolase; Provisional; Region: eno; PRK00077 656024001709 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 656024001710 dimer interface [polypeptide binding]; other site 656024001711 metal binding site [ion binding]; metal-binding site 656024001712 substrate binding pocket [chemical binding]; other site 656024001713 Septum formation initiator; Region: DivIC; pfam04977 656024001714 Protein of unknown function (DUF501); Region: DUF501; pfam04417 656024001715 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 656024001716 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 656024001717 Winged helix-turn helix; Region: HTH_29; pfam13551 656024001718 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024001719 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024001720 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024001721 DNA-binding interface [nucleotide binding]; DNA binding site 656024001722 putative transposase OrfB; Reviewed; Region: PHA02517 656024001723 HTH-like domain; Region: HTH_21; pfam13276 656024001724 Integrase core domain; Region: rve; pfam00665 656024001725 Integrase core domain; Region: rve_3; pfam13683 656024001726 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 656024001727 Fe-S cluster binding site [ion binding]; other site 656024001728 DNA binding site [nucleotide binding] 656024001729 active site 656024001730 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 656024001731 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 656024001732 Bax inhibitor 1 like; Region: BaxI_1; cl17691 656024001733 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 656024001734 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 656024001735 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 656024001736 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 656024001737 TAP-like protein; Region: Abhydrolase_4; pfam08386 656024001738 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656024001739 putative active site [active] 656024001740 heme pocket [chemical binding]; other site 656024001741 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 656024001742 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656024001743 metal binding site [ion binding]; metal-binding site 656024001744 active site 656024001745 I-site; other site 656024001746 PAS fold; Region: PAS; pfam00989 656024001747 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656024001748 putative active site [active] 656024001749 heme pocket [chemical binding]; other site 656024001750 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 656024001751 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656024001752 metal binding site [ion binding]; metal-binding site 656024001753 active site 656024001754 I-site; other site 656024001755 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 656024001756 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 656024001757 metal ion-dependent adhesion site (MIDAS); other site 656024001758 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 656024001759 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 656024001760 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 656024001761 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 656024001762 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 656024001763 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 656024001764 tellurite resistance protein terB; Region: terB; cd07176 656024001765 putative metal binding site [ion binding]; other site 656024001766 hypothetical protein; Provisional; Region: PRK09256 656024001767 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 656024001768 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 656024001769 aminoacyl-tRNA ligase; Region: PLN02563 656024001770 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 656024001771 active site 656024001772 HIGH motif; other site 656024001773 nucleotide binding site [chemical binding]; other site 656024001774 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 656024001775 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 656024001776 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 656024001777 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 656024001778 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 656024001779 active site 656024001780 KMSKS motif; other site 656024001781 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 656024001782 tRNA binding surface [nucleotide binding]; other site 656024001783 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 656024001784 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 656024001785 catalytic residues [active] 656024001786 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 656024001787 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 656024001788 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 656024001789 active site 656024001790 substrate-binding site [chemical binding]; other site 656024001791 metal-binding site [ion binding] 656024001792 GTP binding site [chemical binding]; other site 656024001793 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 656024001794 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 656024001795 putative active site [active] 656024001796 PhoH-like protein; Region: PhoH; pfam02562 656024001797 methionine sulfoxide reductase A; Provisional; Region: PRK00058 656024001798 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 656024001799 putative FMN binding site [chemical binding]; other site 656024001800 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 656024001801 putative hydrophobic ligand binding site [chemical binding]; other site 656024001802 protein interface [polypeptide binding]; other site 656024001803 gate; other site 656024001804 Winged helix-turn helix; Region: HTH_29; pfam13551 656024001805 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024001806 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 656024001807 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 656024001808 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 656024001809 nudix motif; other site 656024001810 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 656024001811 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 656024001812 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 656024001813 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 656024001814 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 656024001815 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 656024001816 fumarate hydratase; Reviewed; Region: fumC; PRK00485 656024001817 aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596 656024001818 active sites [active] 656024001819 tetramer interface [polypeptide binding]; other site 656024001820 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 656024001821 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 656024001822 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 656024001823 putative active site [active] 656024001824 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 656024001825 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 656024001826 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 656024001827 adenosine deaminase; Provisional; Region: PRK09358 656024001828 active site 656024001829 De-etiolated protein 1 Det1; Region: Det1; pfam09737 656024001830 PemK-like protein; Region: PemK; pfam02452 656024001831 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 656024001832 active site 656024001833 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 656024001834 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 656024001835 putative active site [active] 656024001836 putative metal binding site [ion binding]; other site 656024001837 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 656024001838 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 656024001839 generic binding surface II; other site 656024001840 generic binding surface I; other site 656024001841 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 656024001842 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 656024001843 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 656024001844 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 656024001845 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 656024001846 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 656024001847 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 656024001848 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 656024001849 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 656024001850 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 656024001851 active site 656024001852 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 656024001853 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 656024001854 Ligand binding site; other site 656024001855 Putative Catalytic site; other site 656024001856 DXD motif; other site 656024001857 RmuC family; Region: RmuC; pfam02646 656024001858 GTP-binding protein YchF; Reviewed; Region: PRK09601 656024001859 YchF GTPase; Region: YchF; cd01900 656024001860 G1 box; other site 656024001861 GTP/Mg2+ binding site [chemical binding]; other site 656024001862 Switch I region; other site 656024001863 G2 box; other site 656024001864 Switch II region; other site 656024001865 G3 box; other site 656024001866 G4 box; other site 656024001867 G5 box; other site 656024001868 Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071 656024001869 TIR domain; Region: TIR_2; pfam13676 656024001870 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 656024001871 Right handed beta helix region; Region: Beta_helix; pfam13229 656024001872 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 656024001873 aromatic arch; other site 656024001874 DCoH dimer interaction site [polypeptide binding]; other site 656024001875 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 656024001876 DCoH tetramer interaction site [polypeptide binding]; other site 656024001877 substrate binding site [chemical binding]; other site 656024001878 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 656024001879 active site 656024001880 8-oxo-dGMP binding site [chemical binding]; other site 656024001881 nudix motif; other site 656024001882 metal binding site [ion binding]; metal-binding site 656024001883 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 656024001884 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 656024001885 G1 box; other site 656024001886 putative GEF interaction site [polypeptide binding]; other site 656024001887 GTP/Mg2+ binding site [chemical binding]; other site 656024001888 Switch I region; other site 656024001889 G2 box; other site 656024001890 G3 box; other site 656024001891 Switch II region; other site 656024001892 G4 box; other site 656024001893 G5 box; other site 656024001894 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 656024001895 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 656024001896 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 656024001897 potential frameshift: common BLAST hit: gi|334345518|ref|YP_004554070.1| aminoglycoside phosphotransferase 656024001898 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 656024001899 putative active site [active] 656024001900 ATP binding site [chemical binding]; other site 656024001901 putative substrate binding site [chemical binding]; other site 656024001902 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 656024001903 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 656024001904 Ferredoxin [Energy production and conversion]; Region: COG1146 656024001905 4Fe-4S binding domain; Region: Fer4; pfam00037 656024001906 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 656024001907 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 656024001908 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656024001909 homodimer interface [polypeptide binding]; other site 656024001910 catalytic residue [active] 656024001911 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 656024001912 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 656024001913 trimer interface [polypeptide binding]; other site 656024001914 active site 656024001915 substrate binding site [chemical binding]; other site 656024001916 CoA binding site [chemical binding]; other site 656024001917 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 656024001918 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 656024001919 metal binding site [ion binding]; metal-binding site 656024001920 putative dimer interface [polypeptide binding]; other site 656024001921 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 656024001922 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 656024001923 dihydropteroate synthase; Region: DHPS; TIGR01496 656024001924 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 656024001925 substrate binding pocket [chemical binding]; other site 656024001926 dimer interface [polypeptide binding]; other site 656024001927 inhibitor binding site; inhibition site 656024001928 DivIVA domain; Region: DivI1A_domain; TIGR03544 656024001929 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 656024001930 multifunctional aminopeptidase A; Provisional; Region: PRK00913 656024001931 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 656024001932 interface (dimer of trimers) [polypeptide binding]; other site 656024001933 Substrate-binding/catalytic site; other site 656024001934 Zn-binding sites [ion binding]; other site 656024001935 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 656024001936 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 656024001937 S-adenosylmethionine binding site [chemical binding]; other site 656024001938 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 656024001939 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 656024001940 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 656024001941 DNA binding residues [nucleotide binding] 656024001942 Putative zinc-finger; Region: zf-HC2; pfam13490 656024001943 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 656024001944 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 656024001945 sec-independent translocase; Provisional; Region: PRK01371 656024001946 Domain of unknown function DUF59; Region: DUF59; pfam01883 656024001947 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 656024001948 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 656024001949 Transcriptional regulators [Transcription]; Region: MarR; COG1846 656024001950 MarR family; Region: MarR; pfam01047 656024001951 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 656024001952 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 656024001953 active site 656024001954 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 656024001955 PhoD-like phosphatase; Region: PhoD; pfam09423 656024001956 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 656024001957 putative active site [active] 656024001958 putative metal binding site [ion binding]; other site 656024001959 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 656024001960 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 656024001961 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 656024001962 Protein kinase domain; Region: Pkinase; pfam00069 656024001963 Catalytic domain of Protein Kinases; Region: PKc; cd00180 656024001964 active site 656024001965 ATP binding site [chemical binding]; other site 656024001966 substrate binding site [chemical binding]; other site 656024001967 activation loop (A-loop); other site 656024001968 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 656024001969 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 656024001970 NAD(P) binding site [chemical binding]; other site 656024001971 catalytic residues [active] 656024001972 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 656024001973 CrcB-like protein; Region: CRCB; pfam02537 656024001974 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 656024001975 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 656024001976 YCII-related domain; Region: YCII; cl00999 656024001977 Protein of unknown function (DUF433); Region: DUF433; pfam04255 656024001978 DNA methylase; Region: N6_N4_Mtase; cl17433 656024001979 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 656024001980 nudix motif; other site 656024001981 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 656024001982 putative active site [active] 656024001983 putative catalytic site [active] 656024001984 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 656024001985 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 656024001986 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 656024001987 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 656024001988 putative metal binding site [ion binding]; other site 656024001989 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 656024001990 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 656024001991 putative metal binding site [ion binding]; other site 656024001992 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 656024001993 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 656024001994 active site 656024001995 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 656024001996 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 656024001997 putative active site [active] 656024001998 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 656024001999 MgtE intracellular N domain; Region: MgtE_N; smart00924 656024002000 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 656024002001 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 656024002002 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 656024002003 Chorismate mutase type II; Region: CM_2; cl00693 656024002004 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 656024002005 hypothetical protein; Provisional; Region: PRK08912 656024002006 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 656024002007 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656024002008 homodimer interface [polypeptide binding]; other site 656024002009 catalytic residue [active] 656024002010 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 656024002011 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 656024002012 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 656024002013 Domain of unknown function DUF21; Region: DUF21; pfam01595 656024002014 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 656024002015 Domain of unknown function DUF21; Region: DUF21; pfam01595 656024002016 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 656024002017 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 656024002018 Transporter associated domain; Region: CorC_HlyC; smart01091 656024002019 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 656024002020 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 656024002021 P-loop; other site 656024002022 Magnesium ion binding site [ion binding]; other site 656024002023 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 656024002024 Magnesium ion binding site [ion binding]; other site 656024002025 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 656024002026 DEAD-like helicases superfamily; Region: DEXDc; smart00487 656024002027 ATP binding site [chemical binding]; other site 656024002028 Mg++ binding site [ion binding]; other site 656024002029 motif III; other site 656024002030 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 656024002031 nucleotide binding region [chemical binding]; other site 656024002032 ATP-binding site [chemical binding]; other site 656024002033 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 656024002034 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 656024002035 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656024002036 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024002037 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 656024002038 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 656024002039 putative DNA binding site [nucleotide binding]; other site 656024002040 putative homodimer interface [polypeptide binding]; other site 656024002041 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 656024002042 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 656024002043 ATP binding site [chemical binding]; other site 656024002044 substrate interface [chemical binding]; other site 656024002045 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 656024002046 active site residue [active] 656024002047 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 656024002048 DNA binding site [nucleotide binding] 656024002049 active site 656024002050 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 656024002051 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 656024002052 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 656024002053 AAA domain; Region: AAA_30; pfam13604 656024002054 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 656024002055 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 656024002056 Family description; Region: UvrD_C_2; pfam13538 656024002057 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 656024002058 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 656024002059 non-specific DNA binding site [nucleotide binding]; other site 656024002060 salt bridge; other site 656024002061 sequence-specific DNA binding site [nucleotide binding]; other site 656024002062 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 656024002063 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 656024002064 active site 656024002065 HIGH motif; other site 656024002066 dimer interface [polypeptide binding]; other site 656024002067 KMSKS motif; other site 656024002068 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 656024002069 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 656024002070 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 656024002071 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 656024002072 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 656024002073 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 656024002074 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 656024002075 ANTAR domain; Region: ANTAR; pfam03861 656024002076 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 656024002077 catalytic residues [active] 656024002078 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 656024002079 Part of AAA domain; Region: AAA_19; pfam13245 656024002080 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 656024002081 Family description; Region: UvrD_C_2; pfam13538 656024002082 HRDC domain; Region: HRDC; pfam00570 656024002083 Transcription factor WhiB; Region: Whib; pfam02467 656024002084 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 656024002085 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 656024002086 Abi-like protein; Region: Abi_2; pfam07751 656024002087 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 656024002088 Cytochrome P450; Region: p450; cl12078 656024002089 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 656024002090 Cytochrome P450; Region: p450; cl12078 656024002091 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 656024002092 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 656024002093 ABC1 family; Region: ABC1; pfam03109 656024002094 serine/threonine protein kinase; Provisional; Region: PRK14879 656024002095 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 656024002096 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 656024002097 substrate binding site [chemical binding]; other site 656024002098 oxyanion hole (OAH) forming residues; other site 656024002099 trimer interface [polypeptide binding]; other site 656024002100 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 656024002101 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 656024002102 MoaE homodimer interface [polypeptide binding]; other site 656024002103 MoaD interaction [polypeptide binding]; other site 656024002104 active site residues [active] 656024002105 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 656024002106 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 656024002107 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 656024002108 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 656024002109 Uncharacterized conserved protein [Function unknown]; Region: COG1615 656024002110 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 656024002111 Int/Topo IB signature motif; other site 656024002112 Helix-turn-helix domain; Region: HTH_17; pfam12728 656024002113 AAA domain; Region: AAA_25; pfam13481 656024002114 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 656024002115 Walker A motif; other site 656024002116 ATP binding site [chemical binding]; other site 656024002117 Walker B motif; other site 656024002118 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 656024002119 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 656024002120 active site 656024002121 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 656024002122 non-specific DNA binding site [nucleotide binding]; other site 656024002123 salt bridge; other site 656024002124 sequence-specific DNA binding site [nucleotide binding]; other site 656024002125 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 656024002126 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 656024002127 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 656024002128 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 656024002129 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 656024002130 inhibitor-cofactor binding pocket; inhibition site 656024002131 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656024002132 catalytic residue [active] 656024002133 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 656024002134 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 656024002135 inhibitor-cofactor binding pocket; inhibition site 656024002136 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656024002137 catalytic residue [active] 656024002138 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 656024002139 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 656024002140 tetrameric interface [polypeptide binding]; other site 656024002141 NAD binding site [chemical binding]; other site 656024002142 catalytic residues [active] 656024002143 substrate binding site [chemical binding]; other site 656024002144 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 656024002145 Secretory lipase; Region: LIP; pfam03583 656024002146 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 656024002147 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 656024002148 active site 656024002149 catalytic site [active] 656024002150 metal binding site [ion binding]; metal-binding site 656024002151 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 656024002152 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 656024002153 active site 656024002154 ribosome small subunit-dependent GTPase A; Region: TIGR00157 656024002155 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 656024002156 GTPase/Zn-binding domain interface [polypeptide binding]; other site 656024002157 GTP/Mg2+ binding site [chemical binding]; other site 656024002158 G4 box; other site 656024002159 G1 box; other site 656024002160 Switch I region; other site 656024002161 G2 box; other site 656024002162 G3 box; other site 656024002163 Switch II region; other site 656024002164 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 656024002165 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 656024002166 hinge; other site 656024002167 active site 656024002168 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 656024002169 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 656024002170 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 656024002171 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 656024002172 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 656024002173 DNA binding residues [nucleotide binding] 656024002174 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 656024002175 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 656024002176 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656024002177 NAD(P) binding site [chemical binding]; other site 656024002178 active site 656024002179 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 656024002180 carboxyltransferase (CT) interaction site; other site 656024002181 biotinylation site [posttranslational modification]; other site 656024002182 biotin synthase; Validated; Region: PRK06256 656024002183 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 656024002184 FeS/SAM binding site; other site 656024002185 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 656024002186 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 656024002187 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 656024002188 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 656024002189 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 656024002190 catalytic residue [active] 656024002191 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 656024002192 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 656024002193 Histidine kinase; Region: HisKA_2; pfam07568 656024002194 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656024002195 ATP binding site [chemical binding]; other site 656024002196 Mg2+ binding site [ion binding]; other site 656024002197 G-X-G motif; other site 656024002198 Transcription factor WhiB; Region: Whib; pfam02467 656024002199 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 656024002200 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 656024002201 active site 656024002202 catalytic site [active] 656024002203 metal binding site [ion binding]; metal-binding site 656024002204 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 656024002205 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 656024002206 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 656024002207 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 656024002208 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 656024002209 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 656024002210 DNA binding residues [nucleotide binding] 656024002211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 656024002212 Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055 656024002213 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 656024002214 Catalytic site [active] 656024002215 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 656024002216 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 656024002217 Malic enzyme, N-terminal domain; Region: malic; pfam00390 656024002218 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 656024002219 NAD(P) binding pocket [chemical binding]; other site 656024002220 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 656024002221 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 656024002222 NAD(P) binding site [chemical binding]; other site 656024002223 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 656024002224 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 656024002225 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 656024002226 TPP-binding site [chemical binding]; other site 656024002227 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 656024002228 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 656024002229 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 656024002230 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 656024002231 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 656024002232 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 656024002233 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 656024002234 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 656024002235 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 656024002236 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 656024002237 L-aspartate oxidase; Provisional; Region: PRK06175 656024002238 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 656024002239 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 656024002240 putative Iron-sulfur protein interface [polypeptide binding]; other site 656024002241 putative proximal heme binding site [chemical binding]; other site 656024002242 putative SdhC-like subunit interface [polypeptide binding]; other site 656024002243 putative distal heme binding site [chemical binding]; other site 656024002244 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 656024002245 putative Iron-sulfur protein interface [polypeptide binding]; other site 656024002246 putative proximal heme binding site [chemical binding]; other site 656024002247 putative SdhD-like interface [polypeptide binding]; other site 656024002248 putative distal heme binding site [chemical binding]; other site 656024002249 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 656024002250 Tyrosine kinase, catalytic domain; Region: TyrKc; smart00219 656024002251 active site 656024002252 ATP binding site [chemical binding]; other site 656024002253 substrate binding site [chemical binding]; other site 656024002254 activation loop (A-loop); other site 656024002255 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 656024002256 Catalytic domain of Protein Kinases; Region: PKc; cd00180 656024002257 active site 656024002258 ATP binding site [chemical binding]; other site 656024002259 substrate binding site [chemical binding]; other site 656024002260 activation loop (A-loop); other site 656024002261 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 656024002262 active site 656024002263 catalytic motif [active] 656024002264 Zn binding site [ion binding]; other site 656024002265 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 656024002266 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 656024002267 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 656024002268 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 656024002269 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 656024002270 adenosine deaminase; Provisional; Region: PRK09358 656024002271 active site 656024002272 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 656024002273 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 656024002274 intersubunit interface [polypeptide binding]; other site 656024002275 active site 656024002276 catalytic residue [active] 656024002277 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 656024002278 active site 656024002279 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 656024002280 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 656024002281 active site 656024002282 substrate binding site [chemical binding]; other site 656024002283 metal binding site [ion binding]; metal-binding site 656024002284 purine nucleoside phosphorylase; Provisional; Region: PRK08202 656024002285 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 656024002286 EamA-like transporter family; Region: EamA; pfam00892 656024002287 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 656024002288 TIR domain; Region: TIR_2; pfam13676 656024002289 TIR domain; Region: TIR_2; pfam13676 656024002290 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 656024002291 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 656024002292 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 656024002293 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 656024002294 AAA domain; Region: AAA_14; pfam13173 656024002295 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 656024002296 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 656024002297 dimer interface [polypeptide binding]; other site 656024002298 anticodon binding site; other site 656024002299 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 656024002300 motif 1; other site 656024002301 dimer interface [polypeptide binding]; other site 656024002302 active site 656024002303 motif 2; other site 656024002304 GAD domain; Region: GAD; pfam02938 656024002305 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 656024002306 active site 656024002307 motif 3; other site 656024002308 carboxylate-amine ligase; Provisional; Region: PRK13517 656024002309 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 656024002310 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 656024002311 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 656024002312 metal binding site [ion binding]; metal-binding site 656024002313 putative dimer interface [polypeptide binding]; other site 656024002314 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 656024002315 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 656024002316 MarR family; Region: MarR; pfam01047 656024002317 MarR family; Region: MarR_2; cl17246 656024002318 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 656024002319 putative active site pocket [active] 656024002320 dimerization interface [polypeptide binding]; other site 656024002321 putative catalytic residue [active] 656024002322 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 656024002323 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 656024002324 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 656024002325 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 656024002326 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 656024002327 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 656024002328 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 656024002329 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 656024002330 carboxyltransferase (CT) interaction site; other site 656024002331 biotinylation site [posttranslational modification]; other site 656024002332 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 656024002333 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 656024002334 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 656024002335 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 656024002336 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 656024002337 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 656024002338 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 656024002339 Bacterial PH domain; Region: DUF304; pfam03703 656024002340 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 656024002341 nucleotide binding site [chemical binding]; other site 656024002342 putative NEF/HSP70 interaction site [polypeptide binding]; other site 656024002343 SBD interface [polypeptide binding]; other site 656024002344 Predicted membrane protein [Function unknown]; Region: COG2246 656024002345 GtrA-like protein; Region: GtrA; pfam04138 656024002346 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 656024002347 active site clefts [active] 656024002348 zinc binding site [ion binding]; other site 656024002349 dimer interface [polypeptide binding]; other site 656024002350 TIGR03089 family protein; Region: TIGR03089 656024002351 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 656024002352 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 656024002353 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 656024002354 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 656024002355 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 656024002356 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 656024002357 substrate binding site; other site 656024002358 metal-binding site 656024002359 Oligomer interface; other site 656024002360 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 656024002361 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 656024002362 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 656024002363 NADP binding site [chemical binding]; other site 656024002364 active site 656024002365 putative substrate binding site [chemical binding]; other site 656024002366 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 656024002367 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 656024002368 active site 656024002369 HIGH motif; other site 656024002370 KMSKS motif; other site 656024002371 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 656024002372 tRNA binding surface [nucleotide binding]; other site 656024002373 anticodon binding site; other site 656024002374 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 656024002375 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 656024002376 S-adenosylmethionine binding site [chemical binding]; other site 656024002377 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 656024002378 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024002379 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024002380 DNA-binding interface [nucleotide binding]; DNA binding site 656024002381 putative transposase OrfB; Reviewed; Region: PHA02517 656024002382 HTH-like domain; Region: HTH_21; pfam13276 656024002383 Integrase core domain; Region: rve; pfam00665 656024002384 Integrase core domain; Region: rve_3; pfam13683 656024002385 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 656024002386 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 656024002387 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 656024002388 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 656024002389 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 656024002390 Probable Catalytic site; other site 656024002391 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 656024002392 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 656024002393 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 656024002394 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 656024002395 Walker A/P-loop; other site 656024002396 ATP binding site [chemical binding]; other site 656024002397 Q-loop/lid; other site 656024002398 ABC transporter signature motif; other site 656024002399 Walker B; other site 656024002400 D-loop; other site 656024002401 H-loop/switch region; other site 656024002402 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 656024002403 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 656024002404 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 656024002405 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 656024002406 Methyltransferase domain; Region: Methyltransf_24; pfam13578 656024002407 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 656024002408 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 656024002409 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 656024002410 trimer interface [polypeptide binding]; other site 656024002411 active site 656024002412 substrate binding site [chemical binding]; other site 656024002413 CoA binding site [chemical binding]; other site 656024002414 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 656024002415 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 656024002416 Ligand binding site; other site 656024002417 Putative Catalytic site; other site 656024002418 DXD motif; other site 656024002419 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 656024002420 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 656024002421 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 656024002422 PASTA domain; Region: PASTA; pfam03793 656024002423 Methyltransferase domain; Region: Methyltransf_23; pfam13489 656024002424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 656024002425 S-adenosylmethionine binding site [chemical binding]; other site 656024002426 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 656024002427 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 656024002428 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 656024002429 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 656024002430 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 656024002431 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 656024002432 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 656024002433 Probable Catalytic site; other site 656024002434 metal-binding site 656024002435 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 656024002436 putative active site [active] 656024002437 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 656024002438 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 656024002439 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 656024002440 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 656024002441 active site 656024002442 Substrate binding site; other site 656024002443 Mg++ binding site; other site 656024002444 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 656024002445 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 656024002446 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 656024002447 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 656024002448 putative FMN binding site [chemical binding]; other site 656024002449 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 656024002450 phosphate binding site [ion binding]; other site 656024002451 dimer interface [polypeptide binding]; other site 656024002452 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cl00425 656024002453 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656024002454 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024002455 FO synthase; Reviewed; Region: fbiC; PRK09234 656024002456 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 656024002457 FeS/SAM binding site; other site 656024002458 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 656024002459 FeS/SAM binding site; other site 656024002460 Transcription factor WhiB; Region: Whib; pfam02467 656024002461 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 656024002462 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 656024002463 active site 656024002464 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 656024002465 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 656024002466 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 656024002467 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 656024002468 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 656024002469 active site 656024002470 substrate binding site [chemical binding]; other site 656024002471 metal binding site [ion binding]; metal-binding site 656024002472 Trm112p-like protein; Region: Trm112p; cl01066 656024002473 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 656024002474 Bacterial phospho-glucose isomerase C-terminal region; Region: bact-PGI_C; pfam10432 656024002475 Transglycosylase; Region: Transgly; pfam00912 656024002476 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 656024002477 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 656024002478 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 656024002479 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 656024002480 homotetramer interface [polypeptide binding]; other site 656024002481 ligand binding site [chemical binding]; other site 656024002482 catalytic site [active] 656024002483 NAD binding site [chemical binding]; other site 656024002484 RDD family; Region: RDD; pfam06271 656024002485 Integral membrane protein DUF95; Region: DUF95; pfam01944 656024002486 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 656024002487 Protein of unknown function DUF58; Region: DUF58; pfam01882 656024002488 MoxR-like ATPases [General function prediction only]; Region: COG0714 656024002489 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 656024002490 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 656024002491 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 656024002492 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 656024002493 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 656024002494 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 656024002495 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 656024002496 30S subunit binding site; other site 656024002497 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 656024002498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 656024002499 active site 656024002500 phosphorylation site [posttranslational modification] 656024002501 intermolecular recognition site; other site 656024002502 dimerization interface [polypeptide binding]; other site 656024002503 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 656024002504 DNA binding residues [nucleotide binding] 656024002505 dimerization interface [polypeptide binding]; other site 656024002506 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 656024002507 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 656024002508 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 656024002509 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 656024002510 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 656024002511 nucleotide binding region [chemical binding]; other site 656024002512 SEC-C motif; Region: SEC-C; pfam02810 656024002513 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 656024002514 Helix-turn-helix domain; Region: HTH_17; pfam12728 656024002515 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 656024002516 AAA domain; Region: AAA_31; pfam13614 656024002517 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 656024002518 non-specific DNA binding site [nucleotide binding]; other site 656024002519 salt bridge; other site 656024002520 sequence-specific DNA binding site [nucleotide binding]; other site 656024002521 Patatin-like phospholipase; Region: Patatin; pfam01734 656024002522 nucleophile elbow; other site 656024002523 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 656024002524 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 656024002525 NAD(P) binding site [chemical binding]; other site 656024002526 catalytic residues [active] 656024002527 Uncharacterized conserved protein [Function unknown]; Region: COG3743 656024002528 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 656024002529 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 656024002530 ATP binding site [chemical binding]; other site 656024002531 Walker A motif; other site 656024002532 hexamer interface [polypeptide binding]; other site 656024002533 Walker B motif; other site 656024002534 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 656024002535 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 656024002536 Predicted ATPase [General function prediction only]; Region: COG1485 656024002537 Catalytic domain of Protein Kinases; Region: PKc; cd00180 656024002538 active site 656024002539 ATP binding site [chemical binding]; other site 656024002540 substrate binding site [chemical binding]; other site 656024002541 activation loop (A-loop); other site 656024002542 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 656024002543 peptide chain release factor 2; Validated; Region: prfB; PRK00578 656024002544 This domain is found in peptide chain release factors; Region: PCRF; smart00937 656024002545 RF-1 domain; Region: RF-1; pfam00472 656024002546 TIR domain; Region: TIR_2; pfam13676 656024002547 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 656024002548 homodimer interface [polypeptide binding]; other site 656024002549 active site 656024002550 SAM binding site [chemical binding]; other site 656024002551 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 656024002552 AAA domain; Region: AAA_33; pfam13671 656024002553 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 656024002554 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 656024002555 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 656024002556 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024002557 Walker A/P-loop; other site 656024002558 ATP binding site [chemical binding]; other site 656024002559 Q-loop/lid; other site 656024002560 ABC transporter signature motif; other site 656024002561 Walker B; other site 656024002562 D-loop; other site 656024002563 H-loop/switch region; other site 656024002564 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 656024002565 FtsX-like permease family; Region: FtsX; pfam02687 656024002566 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 656024002567 SmpB-tmRNA interface; other site 656024002568 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656024002569 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024002570 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 656024002571 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 656024002572 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 656024002573 catalytic site [active] 656024002574 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 656024002575 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 656024002576 active site 656024002577 nucleotide binding site [chemical binding]; other site 656024002578 HIGH motif; other site 656024002579 KMSKS motif; other site 656024002580 Transcriptional regulators [Transcription]; Region: MarR; COG1846 656024002581 MarR family; Region: MarR_2; pfam12802 656024002582 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 656024002583 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 656024002584 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 656024002585 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 656024002586 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 656024002587 FOG: CBS domain [General function prediction only]; Region: COG0517 656024002588 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 656024002589 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 656024002590 MMPL family; Region: MMPL; pfam03176 656024002591 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656024002592 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024002593 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 656024002594 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 656024002595 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656024002596 NAD(P) binding site [chemical binding]; other site 656024002597 active site 656024002598 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 656024002599 active site lid residues [active] 656024002600 substrate binding pocket [chemical binding]; other site 656024002601 catalytic residues [active] 656024002602 substrate-Mg2+ binding site; other site 656024002603 aspartate-rich region 1; other site 656024002604 aspartate-rich region 2; other site 656024002605 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 656024002606 active site lid residues [active] 656024002607 substrate binding pocket [chemical binding]; other site 656024002608 catalytic residues [active] 656024002609 substrate-Mg2+ binding site; other site 656024002610 aspartate-rich region 1; other site 656024002611 aspartate-rich region 2; other site 656024002612 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 656024002613 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 656024002614 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 656024002615 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 656024002616 substrate binding pocket [chemical binding]; other site 656024002617 chain length determination region; other site 656024002618 substrate-Mg2+ binding site; other site 656024002619 catalytic residues [active] 656024002620 aspartate-rich region 1; other site 656024002621 active site lid residues [active] 656024002622 aspartate-rich region 2; other site 656024002623 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 656024002624 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 656024002625 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 656024002626 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 656024002627 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 656024002628 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 656024002629 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 656024002630 Catalytic domain of Protein Kinases; Region: PKc; cd00180 656024002631 active site 656024002632 ATP binding site [chemical binding]; other site 656024002633 substrate binding site [chemical binding]; other site 656024002634 activation loop (A-loop); other site 656024002635 NMT1/THI5 like; Region: NMT1; pfam09084 656024002636 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 656024002637 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 656024002638 FeS/SAM binding site; other site 656024002639 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 656024002640 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656024002641 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024002642 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024002643 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024002644 DNA-binding interface [nucleotide binding]; DNA binding site 656024002645 putative transposase OrfB; Reviewed; Region: PHA02517 656024002646 HTH-like domain; Region: HTH_21; pfam13276 656024002647 Integrase core domain; Region: rve; pfam00665 656024002648 Integrase core domain; Region: rve_3; pfam13683 656024002649 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 656024002650 CoenzymeA binding site [chemical binding]; other site 656024002651 subunit interaction site [polypeptide binding]; other site 656024002652 PHB binding site; other site 656024002653 UreD urease accessory protein; Region: UreD; pfam01774 656024002654 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 656024002655 Homeodomain-like domain; Region: HTH_23; pfam13384 656024002656 Winged helix-turn helix; Region: HTH_29; pfam13551 656024002657 Homeodomain-like domain; Region: HTH_32; pfam13565 656024002658 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024002659 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 656024002660 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 656024002661 UreF; Region: UreF; pfam01730 656024002662 urease subunit alpha; Reviewed; Region: ureC; PRK13206 656024002663 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 656024002664 subunit interactions [polypeptide binding]; other site 656024002665 active site 656024002666 flap region; other site 656024002667 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 656024002668 gamma-beta subunit interface [polypeptide binding]; other site 656024002669 alpha-beta subunit interface [polypeptide binding]; other site 656024002670 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 656024002671 alpha-gamma subunit interface [polypeptide binding]; other site 656024002672 beta-gamma subunit interface [polypeptide binding]; other site 656024002673 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 656024002674 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 656024002675 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 656024002676 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 656024002677 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 656024002678 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 656024002679 iron-sulfur cluster [ion binding]; other site 656024002680 [2Fe-2S] cluster binding site [ion binding]; other site 656024002681 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 656024002682 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 656024002683 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 656024002684 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 656024002685 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 656024002686 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 656024002687 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 656024002688 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 656024002689 putative bifunctional allantoicase/OHCU decarboxylase; Provisional; Region: PRK13797 656024002690 Allantoicase repeat; Region: Allantoicase; pfam03561 656024002691 Allantoicase repeat; Region: Allantoicase; pfam03561 656024002692 OHCU decarboxylase; Region: UraD_2; TIGR03180 656024002693 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 656024002694 active site 656024002695 homotetramer interface [polypeptide binding]; other site 656024002696 Domain of unknown function (DUF202); Region: DUF202; cl09954 656024002697 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 656024002698 Divergent AAA domain; Region: AAA_4; pfam04326 656024002699 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 656024002700 AAA domain; Region: AAA_14; pfam13173 656024002701 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 656024002702 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 656024002703 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 656024002704 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 656024002705 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 656024002706 Precorrin-8X methylmutase; Region: CbiC; pfam02570 656024002707 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 656024002708 putative homodimer interface [polypeptide binding]; other site 656024002709 active site 656024002710 SAM binding site [chemical binding]; other site 656024002711 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 656024002712 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 656024002713 S-adenosylmethionine binding site [chemical binding]; other site 656024002714 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 656024002715 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 656024002716 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 656024002717 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 656024002718 Protein of unknown function DUF86; Region: DUF86; cl01031 656024002719 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 656024002720 active site 656024002721 NTP binding site [chemical binding]; other site 656024002722 metal binding triad [ion binding]; metal-binding site 656024002723 antibiotic binding site [chemical binding]; other site 656024002724 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 656024002725 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 656024002726 active site 656024002727 putative substrate binding pocket [chemical binding]; other site 656024002728 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 656024002729 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 656024002730 agmatinase; Region: agmatinase; TIGR01230 656024002731 Agmatinase-like family; Region: Agmatinase-like; cd09990 656024002732 active site 656024002733 oligomer interface [polypeptide binding]; other site 656024002734 Mn binding site [ion binding]; other site 656024002735 Transcriptional regulators [Transcription]; Region: MarR; COG1846 656024002736 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 656024002737 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 656024002738 putative ligand binding site [chemical binding]; other site 656024002739 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 656024002740 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 656024002741 Walker A/P-loop; other site 656024002742 ATP binding site [chemical binding]; other site 656024002743 Q-loop/lid; other site 656024002744 ABC transporter signature motif; other site 656024002745 Walker B; other site 656024002746 D-loop; other site 656024002747 H-loop/switch region; other site 656024002748 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 656024002749 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 656024002750 Walker A/P-loop; other site 656024002751 ATP binding site [chemical binding]; other site 656024002752 Q-loop/lid; other site 656024002753 ABC transporter signature motif; other site 656024002754 Walker B; other site 656024002755 D-loop; other site 656024002756 H-loop/switch region; other site 656024002757 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 656024002758 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 656024002759 TM-ABC transporter signature motif; other site 656024002760 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 656024002761 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 656024002762 TM-ABC transporter signature motif; other site 656024002763 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 656024002764 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656024002765 NAD(P) binding site [chemical binding]; other site 656024002766 active site 656024002767 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 656024002768 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 656024002769 non-specific DNA binding site [nucleotide binding]; other site 656024002770 salt bridge; other site 656024002771 sequence-specific DNA binding site [nucleotide binding]; other site 656024002772 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 656024002773 nudix motif; other site 656024002774 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 656024002775 putative nicotinate phosphoribosyltransferase; Region: NAPRTase_put; TIGR01513 656024002776 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 656024002777 active site 656024002778 Winged helix-turn helix; Region: HTH_29; pfam13551 656024002779 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024002780 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656024002781 metal binding site [ion binding]; metal-binding site 656024002782 active site 656024002783 I-site; other site 656024002784 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 656024002785 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 656024002786 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 656024002787 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 656024002788 MPN+ (JAMM) motif; other site 656024002789 Zinc-binding site [ion binding]; other site 656024002790 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 656024002791 MoaE interaction surface [polypeptide binding]; other site 656024002792 MoeB interaction surface [polypeptide binding]; other site 656024002793 thiocarboxylated glycine; other site 656024002794 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 656024002795 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 656024002796 dimer interface [polypeptide binding]; other site 656024002797 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656024002798 catalytic residue [active] 656024002799 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 656024002800 ribonuclease PH; Reviewed; Region: rph; PRK00173 656024002801 Ribonuclease PH; Region: RNase_PH_bact; cd11362 656024002802 hexamer interface [polypeptide binding]; other site 656024002803 active site 656024002804 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 656024002805 active site 656024002806 dimerization interface [polypeptide binding]; other site 656024002807 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 656024002808 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 656024002809 PemK-like protein; Region: PemK; pfam02452 656024002810 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 656024002811 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 656024002812 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 656024002813 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024002814 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024002815 DNA-binding interface [nucleotide binding]; DNA binding site 656024002816 putative transposase OrfB; Reviewed; Region: PHA02517 656024002817 HTH-like domain; Region: HTH_21; pfam13276 656024002818 Integrase core domain; Region: rve; pfam00665 656024002819 Integrase core domain; Region: rve_3; pfam13683 656024002820 Domain of unknown function (DUF4326); Region: DUF4326; pfam14216 656024002821 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 656024002822 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024002823 Transposase; Region: HTH_Tnp_1; pfam01527 656024002824 putative transposase OrfB; Reviewed; Region: PHA02517 656024002825 HTH-like domain; Region: HTH_21; pfam13276 656024002826 Integrase core domain; Region: rve; pfam00665 656024002827 Integrase core domain; Region: rve_3; pfam13683 656024002828 TIR domain; Region: TIR_2; pfam13676 656024002829 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 656024002830 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 656024002831 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 656024002832 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 656024002833 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 656024002834 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 656024002835 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024002836 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024002837 DNA-binding interface [nucleotide binding]; DNA binding site 656024002838 putative transposase OrfB; Reviewed; Region: PHA02517 656024002839 HTH-like domain; Region: HTH_21; pfam13276 656024002840 Integrase core domain; Region: rve; pfam00665 656024002841 Integrase core domain; Region: rve_3; pfam13683 656024002842 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 656024002843 nudix motif; other site 656024002844 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 656024002845 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 656024002846 DNA-binding site [nucleotide binding]; DNA binding site 656024002847 UTRA domain; Region: UTRA; pfam07702 656024002848 Transcription factor WhiB; Region: Whib; pfam02467 656024002849 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 656024002850 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 656024002851 N-acetyl-D-glucosamine binding site [chemical binding]; other site 656024002852 catalytic residue [active] 656024002853 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 656024002854 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 656024002855 nudix motif; other site 656024002856 Helix-turn-helix domain; Region: HTH_36; pfam13730 656024002857 Helix-turn-helix domain; Region: HTH_17; pfam12728 656024002858 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 656024002859 active site 656024002860 catalytic residues [active] 656024002861 DNA binding site [nucleotide binding] 656024002862 Int/Topo IB signature motif; other site 656024002863 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 656024002864 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 656024002865 catalytic triad [active] 656024002866 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 656024002867 S-adenosylmethionine binding site [chemical binding]; other site 656024002868 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 656024002869 Thioredoxin; Region: Thioredoxin_4; pfam13462 656024002870 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 656024002871 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 656024002872 Cu(I) binding site [ion binding]; other site 656024002873 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 656024002874 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 656024002875 metal binding site 2 [ion binding]; metal-binding site 656024002876 putative DNA binding helix; other site 656024002877 metal binding site 1 [ion binding]; metal-binding site 656024002878 dimer interface [polypeptide binding]; other site 656024002879 structural Zn2+ binding site [ion binding]; other site 656024002880 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 656024002881 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 656024002882 tetramer interface [polypeptide binding]; other site 656024002883 heme binding pocket [chemical binding]; other site 656024002884 NADPH binding site [chemical binding]; other site 656024002885 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 656024002886 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 656024002887 catalytic residues [active] 656024002888 dimer interface [polypeptide binding]; other site 656024002889 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 656024002890 nudix motif; other site 656024002891 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 656024002892 nudix motif; other site 656024002893 tellurite resistance protein terB; Region: terB; cd07176 656024002894 putative metal binding site [ion binding]; other site 656024002895 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 656024002896 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 656024002897 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14965 656024002898 Gammaherpesvirus latent membrane protein (LMP2) protein; Region: Herpes_LMP2; pfam07415 656024002899 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 656024002900 oligomerisation interface [polypeptide binding]; other site 656024002901 mobile loop; other site 656024002902 roof hairpin; other site 656024002903 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 656024002904 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 656024002905 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 656024002906 DNA binding residues [nucleotide binding] 656024002907 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 656024002908 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 656024002909 phosphate binding site [ion binding]; other site 656024002910 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 656024002911 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 656024002912 active site 656024002913 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 656024002914 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 656024002915 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 656024002916 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 656024002917 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 656024002918 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 656024002919 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 656024002920 active site 656024002921 TDP-binding site; other site 656024002922 acceptor substrate-binding pocket; other site 656024002923 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 656024002924 ThiC-associated domain; Region: ThiC-associated; pfam13667 656024002925 ThiC family; Region: ThiC; pfam01964 656024002926 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 656024002927 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 656024002928 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 656024002929 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 656024002930 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 656024002931 homodimer interface [polypeptide binding]; other site 656024002932 putative substrate binding pocket [chemical binding]; other site 656024002933 diiron center [ion binding]; other site 656024002934 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 656024002935 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 656024002936 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 656024002937 active site 656024002938 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 656024002939 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 656024002940 active site 656024002941 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 656024002942 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 656024002943 FAD binding domain; Region: FAD_binding_4; pfam01565 656024002944 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 656024002945 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656024002946 NAD(P) binding site [chemical binding]; other site 656024002947 active site 656024002948 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 656024002949 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 656024002950 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 656024002951 phosphopeptide binding site; other site 656024002952 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 656024002953 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 656024002954 phosphopeptide binding site; other site 656024002955 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 656024002956 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 656024002957 Walker A/P-loop; other site 656024002958 ATP binding site [chemical binding]; other site 656024002959 Q-loop/lid; other site 656024002960 ABC transporter signature motif; other site 656024002961 Walker B; other site 656024002962 D-loop; other site 656024002963 H-loop/switch region; other site 656024002964 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 656024002965 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 656024002966 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 656024002967 Catalytic domain of Protein Kinases; Region: PKc; cd00180 656024002968 active site 656024002969 ATP binding site [chemical binding]; other site 656024002970 substrate binding site [chemical binding]; other site 656024002971 activation loop (A-loop); other site 656024002972 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 656024002973 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 656024002974 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 656024002975 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 656024002976 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 656024002977 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 656024002978 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 656024002979 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 656024002980 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 656024002981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 656024002982 active site 656024002983 phosphorylation site [posttranslational modification] 656024002984 intermolecular recognition site; other site 656024002985 dimerization interface [polypeptide binding]; other site 656024002986 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 656024002987 DNA binding residues [nucleotide binding] 656024002988 dimerization interface [polypeptide binding]; other site 656024002989 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 656024002990 Ligand Binding Site [chemical binding]; other site 656024002991 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 656024002992 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 656024002993 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 656024002994 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 656024002995 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 656024002996 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 656024002997 Walker A/P-loop; other site 656024002998 ATP binding site [chemical binding]; other site 656024002999 Q-loop/lid; other site 656024003000 ABC transporter signature motif; other site 656024003001 Walker B; other site 656024003002 D-loop; other site 656024003003 H-loop/switch region; other site 656024003004 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 656024003005 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 656024003006 Walker A/P-loop; other site 656024003007 ATP binding site [chemical binding]; other site 656024003008 Q-loop/lid; other site 656024003009 ABC transporter signature motif; other site 656024003010 Walker B; other site 656024003011 D-loop; other site 656024003012 H-loop/switch region; other site 656024003013 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 656024003014 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 656024003015 GAF domain; Region: GAF_3; pfam13492 656024003016 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 656024003017 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 656024003018 Histidine kinase; Region: HisKA_3; pfam07730 656024003019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656024003020 ATP binding site [chemical binding]; other site 656024003021 Mg2+ binding site [ion binding]; other site 656024003022 G-X-G motif; other site 656024003023 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 656024003024 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 656024003025 TIR domain; Region: TIR_2; pfam13676 656024003026 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 656024003027 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 656024003028 OsmC-like protein; Region: OsmC; pfam02566 656024003029 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 656024003030 intersubunit interface [polypeptide binding]; other site 656024003031 active site 656024003032 Zn2+ binding site [ion binding]; other site 656024003033 glycerol kinase; Provisional; Region: glpK; PRK00047 656024003034 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 656024003035 nucleotide binding site [chemical binding]; other site 656024003036 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 656024003037 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 656024003038 [2Fe-2S] cluster binding site [ion binding]; other site 656024003039 putative transposase OrfB; Reviewed; Region: PHA02517 656024003040 HTH-like domain; Region: HTH_21; pfam13276 656024003041 Integrase core domain; Region: rve; pfam00665 656024003042 Integrase core domain; Region: rve_3; pfam13683 656024003043 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024003044 Transposase; Region: HTH_Tnp_1; pfam01527 656024003045 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024003046 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024003047 DNA-binding interface [nucleotide binding]; DNA binding site 656024003048 putative transposase OrfB; Reviewed; Region: PHA02517 656024003049 HTH-like domain; Region: HTH_21; pfam13276 656024003050 Integrase core domain; Region: rve; pfam00665 656024003051 Integrase core domain; Region: rve_3; pfam13683 656024003052 IPP transferase; Region: IPPT; pfam01715 656024003053 Abortive infection C-terminus; Region: Abi_C; pfam14355 656024003054 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 656024003055 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 656024003056 AAA domain; Region: AAA_14; pfam13173 656024003057 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 656024003058 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 656024003059 DNA-binding site [nucleotide binding]; DNA binding site 656024003060 Major Facilitator Superfamily; Region: MFS_1; pfam07690 656024003061 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024003062 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 656024003063 oligomeric interface; other site 656024003064 putative active site [active] 656024003065 homodimer interface [polypeptide binding]; other site 656024003066 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 656024003067 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 656024003068 active site 656024003069 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 656024003070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024003071 putative substrate translocation pore; other site 656024003072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024003073 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 656024003074 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 656024003075 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024003076 Transposase; Region: HTH_Tnp_1; pfam01527 656024003077 putative transposase OrfB; Reviewed; Region: PHA02517 656024003078 HTH-like domain; Region: HTH_21; pfam13276 656024003079 Integrase core domain; Region: rve; pfam00665 656024003080 Integrase core domain; Region: rve_3; pfam13683 656024003081 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024003082 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024003083 DNA-binding interface [nucleotide binding]; DNA binding site 656024003084 putative transposase OrfB; Reviewed; Region: PHA02517 656024003085 HTH-like domain; Region: HTH_21; pfam13276 656024003086 Integrase core domain; Region: rve; pfam00665 656024003087 Integrase core domain; Region: rve_3; pfam13683 656024003088 Homeodomain-like domain; Region: HTH_23; pfam13384 656024003089 Winged helix-turn helix; Region: HTH_29; pfam13551 656024003090 Homeodomain-like domain; Region: HTH_32; pfam13565 656024003091 Homeodomain-like domain; Region: HTH_23; pfam13384 656024003092 Winged helix-turn helix; Region: HTH_29; pfam13551 656024003093 Homeodomain-like domain; Region: HTH_32; pfam13565 656024003094 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024003095 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 656024003096 A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414 656024003097 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 656024003098 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 656024003099 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 656024003100 active site 656024003101 catalytic residues [active] 656024003102 Protein of unknown function (DUF690); Region: DUF690; cl04939 656024003103 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 656024003104 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 656024003105 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 656024003106 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 656024003107 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 656024003108 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 656024003109 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 656024003110 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 656024003111 RibD C-terminal domain; Region: RibD_C; cl17279 656024003112 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 656024003113 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 656024003114 dimerization interface [polypeptide binding]; other site 656024003115 ligand binding site [chemical binding]; other site 656024003116 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 656024003117 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 656024003118 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 656024003119 TM-ABC transporter signature motif; other site 656024003120 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 656024003121 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 656024003122 TM-ABC transporter signature motif; other site 656024003123 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 656024003124 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 656024003125 Walker A/P-loop; other site 656024003126 ATP binding site [chemical binding]; other site 656024003127 Q-loop/lid; other site 656024003128 ABC transporter signature motif; other site 656024003129 Walker B; other site 656024003130 D-loop; other site 656024003131 H-loop/switch region; other site 656024003132 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 656024003133 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 656024003134 Walker A/P-loop; other site 656024003135 ATP binding site [chemical binding]; other site 656024003136 Q-loop/lid; other site 656024003137 ABC transporter signature motif; other site 656024003138 Walker B; other site 656024003139 D-loop; other site 656024003140 H-loop/switch region; other site 656024003141 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 656024003142 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 656024003143 AAA domain; Region: AAA_14; pfam13173 656024003144 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 656024003145 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 656024003146 metal ion-dependent adhesion site (MIDAS); other site 656024003147 Protein phosphatase 2C; Region: PP2C_2; pfam13672 656024003148 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 656024003149 active site 656024003150 ATP binding site [chemical binding]; other site 656024003151 substrate binding site [chemical binding]; other site 656024003152 activation loop (A-loop); other site 656024003153 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 656024003154 metal ion-dependent adhesion site (MIDAS); other site 656024003155 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 656024003156 substrate binding site [chemical binding]; other site 656024003157 activation loop (A-loop); other site 656024003158 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024003159 Transposase; Region: HTH_Tnp_1; pfam01527 656024003160 putative transposase OrfB; Reviewed; Region: PHA02517 656024003161 HTH-like domain; Region: HTH_21; pfam13276 656024003162 Integrase core domain; Region: rve; pfam00665 656024003163 Integrase core domain; Region: rve_3; pfam13683 656024003164 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 656024003165 Subunit I/III interface [polypeptide binding]; other site 656024003166 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 656024003167 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 656024003168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656024003169 NAD(P) binding site [chemical binding]; other site 656024003170 active site 656024003171 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 656024003172 Permease; Region: Permease; pfam02405 656024003173 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 656024003174 Permease; Region: Permease; pfam02405 656024003175 Homeodomain-like domain; Region: HTH_23; pfam13384 656024003176 Winged helix-turn helix; Region: HTH_29; pfam13551 656024003177 Homeodomain-like domain; Region: HTH_32; pfam13565 656024003178 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024003179 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 656024003180 Glycerate kinase family; Region: Gly_kinase; cl00841 656024003181 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 656024003182 active site 656024003183 catalytic triad [active] 656024003184 Cna protein B-type domain; Region: Cna_B; pfam05738 656024003185 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 656024003186 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 656024003187 catalytic loop [active] 656024003188 iron binding site [ion binding]; other site 656024003189 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 656024003190 L-aspartate oxidase; Provisional; Region: PRK06175 656024003191 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 656024003192 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 656024003193 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 656024003194 Malic enzyme, N-terminal domain; Region: malic; pfam00390 656024003195 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 656024003196 NAD(P) binding pocket [chemical binding]; other site 656024003197 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 656024003198 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 656024003199 putative dimer interface [polypeptide binding]; other site 656024003200 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 656024003201 ThiS interaction site; other site 656024003202 putative active site [active] 656024003203 tetramer interface [polypeptide binding]; other site 656024003204 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 656024003205 thiS-thiF/thiG interaction site; other site 656024003206 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 656024003207 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 656024003208 Catalytic domain of Protein Kinases; Region: PKc; cd00180 656024003209 active site 656024003210 ATP binding site [chemical binding]; other site 656024003211 substrate binding site [chemical binding]; other site 656024003212 activation loop (A-loop); other site 656024003213 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 656024003214 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 656024003215 NodB motif; other site 656024003216 putative active site [active] 656024003217 putative catalytic site [active] 656024003218 putative Zn binding site [ion binding]; other site 656024003219 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 656024003220 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 656024003221 NAD(P) binding site [chemical binding]; other site 656024003222 catalytic residues [active] 656024003223 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 656024003224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 656024003225 active site 656024003226 phosphorylation site [posttranslational modification] 656024003227 intermolecular recognition site; other site 656024003228 dimerization interface [polypeptide binding]; other site 656024003229 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 656024003230 DNA binding residues [nucleotide binding] 656024003231 dimerization interface [polypeptide binding]; other site 656024003232 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 656024003233 Domain of unknown function DUF21; Region: DUF21; pfam01595 656024003234 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 656024003235 Transporter associated domain; Region: CorC_HlyC; smart01091 656024003236 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 656024003237 Domain of unknown function DUF21; Region: DUF21; pfam01595 656024003238 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 656024003239 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 656024003240 putative ligand binding site [chemical binding]; other site 656024003241 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 656024003242 putative NAD binding site [chemical binding]; other site 656024003243 catalytic site [active] 656024003244 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 656024003245 catalytic site [active] 656024003246 putative active site [active] 656024003247 putative substrate binding site [chemical binding]; other site 656024003248 dimer interface [polypeptide binding]; other site 656024003249 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 656024003250 dinuclear metal binding motif [ion binding]; other site 656024003251 Pirin-related protein [General function prediction only]; Region: COG1741 656024003252 Pirin; Region: Pirin; pfam02678 656024003253 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 656024003254 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 656024003255 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656024003256 metal binding site [ion binding]; metal-binding site 656024003257 active site 656024003258 I-site; other site 656024003259 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 656024003260 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 656024003261 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 656024003262 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 656024003263 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 656024003264 catalytic residue [active] 656024003265 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 656024003266 chaperone protein DnaJ; Provisional; Region: PRK14290 656024003267 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 656024003268 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 656024003269 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 656024003270 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 656024003271 ATP binding site [chemical binding]; other site 656024003272 putative Mg++ binding site [ion binding]; other site 656024003273 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 656024003274 nucleotide binding region [chemical binding]; other site 656024003275 ATP-binding site [chemical binding]; other site 656024003276 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 656024003277 HRDC domain; Region: HRDC; pfam00570 656024003278 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 656024003279 active site 656024003280 HTH domain; Region: HTH_11; pfam08279 656024003281 WYL domain; Region: WYL; pfam13280 656024003282 WYL domain; Region: WYL; pfam13280 656024003283 Domain of unknown function (DUF955); Region: DUF955; pfam06114 656024003284 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 656024003285 Catalytic domain of Protein Kinases; Region: PKc; cd00180 656024003286 active site 656024003287 ATP binding site [chemical binding]; other site 656024003288 substrate binding site [chemical binding]; other site 656024003289 activation loop (A-loop); other site 656024003290 FOG: WD40 repeat [General function prediction only]; Region: COG2319 656024003291 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 656024003292 structural tetrad; other site 656024003293 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 656024003294 Coenzyme A binding pocket [chemical binding]; other site 656024003295 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024003296 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024003297 DNA-binding interface [nucleotide binding]; DNA binding site 656024003298 putative transposase OrfB; Reviewed; Region: PHA02517 656024003299 HTH-like domain; Region: HTH_21; pfam13276 656024003300 Integrase core domain; Region: rve; pfam00665 656024003301 Integrase core domain; Region: rve_3; pfam13683 656024003302 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 656024003303 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 656024003304 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 656024003305 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 656024003306 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 656024003307 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 656024003308 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 656024003309 nudix motif; other site 656024003310 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 656024003311 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 656024003312 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 656024003313 dimer interface [polypeptide binding]; other site 656024003314 ssDNA binding site [nucleotide binding]; other site 656024003315 tetramer (dimer of dimers) interface [polypeptide binding]; other site 656024003316 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 656024003317 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 656024003318 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 656024003319 ABC transporter; Region: ABC_tran_2; pfam12848 656024003320 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 656024003321 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 656024003322 apolar tunnel; other site 656024003323 heme binding site [chemical binding]; other site 656024003324 dimerization interface [polypeptide binding]; other site 656024003325 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 656024003326 active site 656024003327 catalytic site [active] 656024003328 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 656024003329 GAF domain; Region: GAF; cl17456 656024003330 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 656024003331 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 656024003332 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 656024003333 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 656024003334 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 656024003335 active site 656024003336 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 656024003337 Mechanosensitive ion channel; Region: MS_channel; pfam00924 656024003338 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 656024003339 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 656024003340 active site 656024003341 phosphorylation site [posttranslational modification] 656024003342 intermolecular recognition site; other site 656024003343 dimerization interface [polypeptide binding]; other site 656024003344 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 656024003345 DNA binding site [nucleotide binding] 656024003346 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 656024003347 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 656024003348 dimerization interface [polypeptide binding]; other site 656024003349 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 656024003350 dimer interface [polypeptide binding]; other site 656024003351 phosphorylation site [posttranslational modification] 656024003352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656024003353 ATP binding site [chemical binding]; other site 656024003354 Mg2+ binding site [ion binding]; other site 656024003355 G-X-G motif; other site 656024003356 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 656024003357 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 656024003358 Repair protein; Region: Repair_PSII; pfam04536 656024003359 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 656024003360 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 656024003361 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 656024003362 putative active site [active] 656024003363 homotetrameric interface [polypeptide binding]; other site 656024003364 metal binding site [ion binding]; metal-binding site 656024003365 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 656024003366 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 656024003367 Zn binding site [ion binding]; other site 656024003368 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 656024003369 Domain of unknown function DUF20; Region: UPF0118; pfam01594 656024003370 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 656024003371 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 656024003372 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 656024003373 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 656024003374 active site 656024003375 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 656024003376 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 656024003377 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 656024003378 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024003379 Walker A/P-loop; other site 656024003380 ATP binding site [chemical binding]; other site 656024003381 Q-loop/lid; other site 656024003382 ABC transporter signature motif; other site 656024003383 Walker B; other site 656024003384 D-loop; other site 656024003385 H-loop/switch region; other site 656024003386 Chorismate lyase; Region: Chor_lyase; cl01230 656024003387 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 656024003388 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024003389 Walker A/P-loop; other site 656024003390 ATP binding site [chemical binding]; other site 656024003391 Q-loop/lid; other site 656024003392 ABC transporter signature motif; other site 656024003393 Walker B; other site 656024003394 D-loop; other site 656024003395 H-loop/switch region; other site 656024003396 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 656024003397 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 656024003398 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 656024003399 putative dimer interface [polypeptide binding]; other site 656024003400 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 656024003401 putative catalytic site [active] 656024003402 putative phosphate binding site [ion binding]; other site 656024003403 active site 656024003404 metal binding site A [ion binding]; metal-binding site 656024003405 DNA binding site [nucleotide binding] 656024003406 putative AP binding site [nucleotide binding]; other site 656024003407 putative metal binding site B [ion binding]; other site 656024003408 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 656024003409 DEAD-like helicases superfamily; Region: DEXDc; smart00487 656024003410 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 656024003411 ATP binding site [chemical binding]; other site 656024003412 putative Mg++ binding site [ion binding]; other site 656024003413 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 656024003414 nucleotide binding region [chemical binding]; other site 656024003415 ATP-binding site [chemical binding]; other site 656024003416 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 656024003417 trigger factor; Provisional; Region: tig; PRK01490 656024003418 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 656024003419 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 656024003420 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 656024003421 Clp protease; Region: CLP_protease; pfam00574 656024003422 oligomer interface [polypeptide binding]; other site 656024003423 active site residues [active] 656024003424 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 656024003425 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 656024003426 oligomer interface [polypeptide binding]; other site 656024003427 active site residues [active] 656024003428 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 656024003429 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 656024003430 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 656024003431 Walker A motif; other site 656024003432 ATP binding site [chemical binding]; other site 656024003433 Walker B motif; other site 656024003434 arginine finger; other site 656024003435 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 656024003436 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 656024003437 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 656024003438 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 656024003439 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 656024003440 active site 656024003441 multimer interface [polypeptide binding]; other site 656024003442 rod shape-determining protein MreB; Provisional; Region: PRK13927 656024003443 MreB and similar proteins; Region: MreB_like; cd10225 656024003444 nucleotide binding site [chemical binding]; other site 656024003445 Mg binding site [ion binding]; other site 656024003446 putative protofilament interaction site [polypeptide binding]; other site 656024003447 RodZ interaction site [polypeptide binding]; other site 656024003448 rod shape-determining protein MreC; Provisional; Region: PRK13922 656024003449 rod shape-determining protein MreC; Region: MreC; pfam04085 656024003450 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 656024003451 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 656024003452 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 656024003453 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 656024003454 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 656024003455 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 656024003456 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 656024003457 B12 binding site [chemical binding]; other site 656024003458 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 656024003459 FeS/SAM binding site; other site 656024003460 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 656024003461 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 656024003462 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 656024003463 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 656024003464 homodimer interface [polypeptide binding]; other site 656024003465 oligonucleotide binding site [chemical binding]; other site 656024003466 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 656024003467 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 656024003468 GTPase CgtA; Reviewed; Region: obgE; PRK12296 656024003469 GTP1/OBG; Region: GTP1_OBG; pfam01018 656024003470 Obg GTPase; Region: Obg; cd01898 656024003471 G1 box; other site 656024003472 GTP/Mg2+ binding site [chemical binding]; other site 656024003473 Switch I region; other site 656024003474 G2 box; other site 656024003475 G3 box; other site 656024003476 Switch II region; other site 656024003477 G4 box; other site 656024003478 G5 box; other site 656024003479 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 656024003480 gamma-glutamyl kinase; Provisional; Region: PRK05429 656024003481 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 656024003482 nucleotide binding site [chemical binding]; other site 656024003483 homotetrameric interface [polypeptide binding]; other site 656024003484 putative phosphate binding site [ion binding]; other site 656024003485 putative allosteric binding site; other site 656024003486 PUA domain; Region: PUA; pfam01472 656024003487 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 656024003488 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024003489 Walker A/P-loop; other site 656024003490 ATP binding site [chemical binding]; other site 656024003491 Q-loop/lid; other site 656024003492 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 656024003493 ABC transporter signature motif; other site 656024003494 Walker B; other site 656024003495 D-loop; other site 656024003496 H-loop/switch region; other site 656024003497 exonuclease SbcD; Region: sbcd; TIGR00619 656024003498 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 656024003499 putative catalytic cysteine [active] 656024003500 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 656024003501 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 656024003502 DXD motif; other site 656024003503 Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250 656024003504 Kelch motif; Region: Kelch_6; pfam13964 656024003505 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 656024003506 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 656024003507 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 656024003508 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 656024003509 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 656024003510 Cu(I) binding site [ion binding]; other site 656024003511 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 656024003512 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 656024003513 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 656024003514 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 656024003515 Walker A motif; other site 656024003516 ATP binding site [chemical binding]; other site 656024003517 Walker B motif; other site 656024003518 arginine finger; other site 656024003519 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 656024003520 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 656024003521 phosphoglucomutase; Validated; Region: PRK07564 656024003522 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 656024003523 active site 656024003524 substrate binding site [chemical binding]; other site 656024003525 metal binding site [ion binding]; metal-binding site 656024003526 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 656024003527 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 656024003528 active site 656024003529 (T/H)XGH motif; other site 656024003530 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 656024003531 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 656024003532 catalytic core [active] 656024003533 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024003534 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024003535 DNA-binding interface [nucleotide binding]; DNA binding site 656024003536 putative transposase OrfB; Reviewed; Region: PHA02517 656024003537 HTH-like domain; Region: HTH_21; pfam13276 656024003538 Integrase core domain; Region: rve; pfam00665 656024003539 Integrase core domain; Region: rve_3; pfam13683 656024003540 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 656024003541 putative active site [active] 656024003542 putative catalytic site [active] 656024003543 Helix-turn-helix domain; Region: HTH_20; pfam12840 656024003544 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 656024003545 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 656024003546 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 656024003547 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 656024003548 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 656024003549 NodB motif; other site 656024003550 active site 656024003551 catalytic site [active] 656024003552 metal binding site [ion binding]; metal-binding site 656024003553 Bacitracin resistance protein BacA; Region: BacA; pfam02673 656024003554 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 656024003555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 656024003556 active site 656024003557 phosphorylation site [posttranslational modification] 656024003558 intermolecular recognition site; other site 656024003559 dimerization interface [polypeptide binding]; other site 656024003560 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 656024003561 DNA binding site [nucleotide binding] 656024003562 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 656024003563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656024003564 Mg2+ binding site [ion binding]; other site 656024003565 G-X-G motif; other site 656024003566 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 656024003567 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 656024003568 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 656024003569 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 656024003570 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656024003571 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024003572 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 656024003573 classical (c) SDRs; Region: SDR_c; cd05233 656024003574 NAD(P) binding site [chemical binding]; other site 656024003575 active site 656024003576 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 656024003577 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 656024003578 active site 656024003579 catalytic tetrad [active] 656024003580 Transcriptional regulator [Transcription]; Region: LysR; COG0583 656024003581 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 656024003582 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 656024003583 putative dimerization interface [polypeptide binding]; other site 656024003584 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 656024003585 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 656024003586 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 656024003587 catalytic site [active] 656024003588 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 656024003589 MarR family; Region: MarR_2; pfam12802 656024003590 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 656024003591 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 656024003592 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 656024003593 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 656024003594 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 656024003595 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 656024003596 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 656024003597 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 656024003598 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 656024003599 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 656024003600 Walker A/P-loop; other site 656024003601 ATP binding site [chemical binding]; other site 656024003602 Q-loop/lid; other site 656024003603 ABC transporter signature motif; other site 656024003604 Walker B; other site 656024003605 D-loop; other site 656024003606 H-loop/switch region; other site 656024003607 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 656024003608 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 656024003609 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 656024003610 TM-ABC transporter signature motif; other site 656024003611 Transcriptional regulators [Transcription]; Region: FadR; COG2186 656024003612 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 656024003613 DNA-binding site [nucleotide binding]; DNA binding site 656024003614 FCD domain; Region: FCD; pfam07729 656024003615 short chain dehydrogenase; Validated; Region: PRK06182 656024003616 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 656024003617 NADP binding site [chemical binding]; other site 656024003618 active site 656024003619 steroid binding site; other site 656024003620 PAC2 family; Region: PAC2; pfam09754 656024003621 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 656024003622 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 656024003623 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 656024003624 XdhC Rossmann domain; Region: XdhC_C; pfam13478 656024003625 Part of AAA domain; Region: AAA_19; pfam13245 656024003626 Family description; Region: UvrD_C_2; pfam13538 656024003627 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 656024003628 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 656024003629 Methyltransferase domain; Region: Methyltransf_11; pfam08241 656024003630 S-adenosylmethionine binding site [chemical binding]; other site 656024003631 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 656024003632 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 656024003633 hydroxyglutarate oxidase; Provisional; Region: PRK11728 656024003634 Transcriptional regulators [Transcription]; Region: FadR; COG2186 656024003635 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 656024003636 DNA-binding site [nucleotide binding]; DNA binding site 656024003637 FCD domain; Region: FCD; pfam07729 656024003638 Winged helix-turn helix; Region: HTH_29; pfam13551 656024003639 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024003640 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 656024003641 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 656024003642 putative acyl-acceptor binding pocket; other site 656024003643 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 656024003644 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 656024003645 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; cl17321 656024003646 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 656024003647 YceI-like domain; Region: YceI; smart00867 656024003648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024003649 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 656024003650 putative substrate translocation pore; other site 656024003651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024003652 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 656024003653 Helix-hairpin-helix motif; Region: HHH; pfam00633 656024003654 Competence protein; Region: Competence; pfam03772 656024003655 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 656024003656 hypothetical protein; Reviewed; Region: PRK07914 656024003657 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 656024003658 GTP-binding protein LepA; Provisional; Region: PRK05433 656024003659 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 656024003660 G1 box; other site 656024003661 putative GEF interaction site [polypeptide binding]; other site 656024003662 GTP/Mg2+ binding site [chemical binding]; other site 656024003663 Switch I region; other site 656024003664 G2 box; other site 656024003665 G3 box; other site 656024003666 Switch II region; other site 656024003667 G4 box; other site 656024003668 G5 box; other site 656024003669 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 656024003670 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 656024003671 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 656024003672 coproporphyrinogen III oxidase; Validated; Region: PRK05628 656024003673 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 656024003674 FeS/SAM binding site; other site 656024003675 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 656024003676 HTH domain; Region: HTH_11; pfam08279 656024003677 chaperone protein DnaJ; Provisional; Region: PRK14278 656024003678 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 656024003679 HSP70 interaction site [polypeptide binding]; other site 656024003680 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 656024003681 Zn binding sites [ion binding]; other site 656024003682 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 656024003683 dimer interface [polypeptide binding]; other site 656024003684 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 656024003685 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 656024003686 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 656024003687 PhoH-like protein; Region: PhoH; pfam02562 656024003688 metal-binding heat shock protein; Provisional; Region: PRK00016 656024003689 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 656024003690 Domain of unknown function DUF21; Region: DUF21; pfam01595 656024003691 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 656024003692 Transporter associated domain; Region: CorC_HlyC; smart01091 656024003693 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 656024003694 GTPase Era; Reviewed; Region: era; PRK00089 656024003695 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 656024003696 G1 box; other site 656024003697 GTP/Mg2+ binding site [chemical binding]; other site 656024003698 Switch I region; other site 656024003699 G2 box; other site 656024003700 Switch II region; other site 656024003701 G3 box; other site 656024003702 G4 box; other site 656024003703 G5 box; other site 656024003704 KH domain; Region: KH_2; pfam07650 656024003705 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 656024003706 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 656024003707 active site 656024003708 metal binding site [ion binding]; metal-binding site 656024003709 TIR domain; Region: TIR_2; pfam13676 656024003710 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 656024003711 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 656024003712 NACHT domain; Region: NACHT; pfam05729 656024003713 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 656024003714 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 656024003715 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 656024003716 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 656024003717 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 656024003718 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 656024003719 FOG: WD40 repeat [General function prediction only]; Region: COG2319 656024003720 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 656024003721 structural tetrad; other site 656024003722 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 656024003723 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 656024003724 Recombination protein O N terminal; Region: RecO_N; pfam11967 656024003725 Recombination protein O C terminal; Region: RecO_C; pfam02565 656024003726 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 656024003727 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 656024003728 catalytic residue [active] 656024003729 putative FPP diphosphate binding site; other site 656024003730 putative FPP binding hydrophobic cleft; other site 656024003731 dimer interface [polypeptide binding]; other site 656024003732 putative IPP diphosphate binding site; other site 656024003733 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 656024003734 glycyl-tRNA synthetase; Provisional; Region: PRK04173 656024003735 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 656024003736 dimer interface [polypeptide binding]; other site 656024003737 motif 1; other site 656024003738 active site 656024003739 motif 2; other site 656024003740 motif 3; other site 656024003741 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 656024003742 anticodon binding site; other site 656024003743 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 656024003744 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 656024003745 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 656024003746 metal ion-dependent adhesion site (MIDAS); other site 656024003747 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 656024003748 pyruvate phosphate dikinase; Provisional; Region: PRK09279 656024003749 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 656024003750 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 656024003751 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 656024003752 Uncharacterized conserved protein [Function unknown]; Region: COG1434 656024003753 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 656024003754 putative active site [active] 656024003755 transketolase; Reviewed; Region: PRK05899 656024003756 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 656024003757 TPP-binding site [chemical binding]; other site 656024003758 dimer interface [polypeptide binding]; other site 656024003759 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 656024003760 PYR/PP interface [polypeptide binding]; other site 656024003761 dimer interface [polypeptide binding]; other site 656024003762 TPP binding site [chemical binding]; other site 656024003763 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 656024003764 Bacterial PH domain; Region: DUF304; pfam03703 656024003765 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 656024003766 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 656024003767 Zn2+ binding site [ion binding]; other site 656024003768 Mg2+ binding site [ion binding]; other site 656024003769 DNA primase; Validated; Region: dnaG; PRK05667 656024003770 CHC2 zinc finger; Region: zf-CHC2; pfam01807 656024003771 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 656024003772 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 656024003773 active site 656024003774 metal binding site [ion binding]; metal-binding site 656024003775 interdomain interaction site; other site 656024003776 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 656024003777 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 656024003778 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 656024003779 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 656024003780 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 656024003781 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 656024003782 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 656024003783 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 656024003784 DNA binding residues [nucleotide binding] 656024003785 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 656024003786 active site 656024003787 catalytic site [active] 656024003788 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 656024003789 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 656024003790 Transposase; Region: HTH_Tnp_Tc3_2; pfam01498 656024003791 DDE superfamily endonuclease; Region: DDE_5; cl17874 656024003792 putative transposase OrfB; Reviewed; Region: PHA02517 656024003793 HTH-like domain; Region: HTH_21; pfam13276 656024003794 Integrase core domain; Region: rve; pfam00665 656024003795 Integrase core domain; Region: rve_3; pfam13683 656024003796 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024003797 Transposase; Region: HTH_Tnp_1; pfam01527 656024003798 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024003799 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 656024003800 Walker A/P-loop; other site 656024003801 ATP binding site [chemical binding]; other site 656024003802 Q-loop/lid; other site 656024003803 ABC transporter signature motif; other site 656024003804 Walker B; other site 656024003805 D-loop; other site 656024003806 H-loop/switch region; other site 656024003807 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 656024003808 ABC-2 type transporter; Region: ABC2_membrane; cl17235 656024003809 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 656024003810 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 656024003811 Winged helix-turn helix; Region: HTH_29; pfam13551 656024003812 Helix-turn-helix domain; Region: HTH_28; pfam13518 656024003813 Homeodomain-like domain; Region: HTH_32; pfam13565 656024003814 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 656024003815 Transposase; Region: HTH_Tnp_1; pfam01527 656024003816 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024003817 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 656024003818 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 656024003819 putative active site [active] 656024003820 putative NTP binding site [chemical binding]; other site 656024003821 putative nucleic acid binding site [nucleotide binding]; other site 656024003822 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 656024003823 HTH-like domain; Region: HTH_21; pfam13276 656024003824 Integrase core domain; Region: rve; pfam00665 656024003825 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 656024003826 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 656024003827 putative active site [active] 656024003828 putative NTP binding site [chemical binding]; other site 656024003829 putative nucleic acid binding site [nucleotide binding]; other site 656024003830 Type II intron maturase; Region: Intron_maturas2; pfam01348 656024003831 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 656024003832 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 656024003833 putative active site [active] 656024003834 putative NTP binding site [chemical binding]; other site 656024003835 putative nucleic acid binding site [nucleotide binding]; other site 656024003836 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 656024003837 Methyltransferase domain; Region: Methyltransf_23; pfam13489 656024003838 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 656024003839 S-adenosylmethionine binding site [chemical binding]; other site 656024003840 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 656024003841 putative transposase OrfB; Reviewed; Region: PHA02517 656024003842 Integrase core domain; Region: rve; pfam00665 656024003843 Integrase core domain; Region: rve_3; pfam13683 656024003844 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 656024003845 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 656024003846 putative metal binding site; other site 656024003847 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 656024003848 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 656024003849 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 656024003850 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 656024003851 active site 656024003852 AMP binding site [chemical binding]; other site 656024003853 Uncharacterized conserved protein [Function unknown]; Region: COG2006 656024003854 Uncharacterized conserved protein [Function unknown]; Region: COG2006 656024003855 Methyltransferase domain; Region: Methyltransf_23; pfam13489 656024003856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 656024003857 S-adenosylmethionine binding site [chemical binding]; other site 656024003858 Methyltransferase domain; Region: Methyltransf_23; pfam13489 656024003859 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 656024003860 S-adenosylmethionine binding site [chemical binding]; other site 656024003861 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 656024003862 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 656024003863 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 656024003864 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 656024003865 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 656024003866 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024003867 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024003868 DNA-binding interface [nucleotide binding]; DNA binding site 656024003869 putative transposase OrfB; Reviewed; Region: PHA02517 656024003870 HTH-like domain; Region: HTH_21; pfam13276 656024003871 Integrase core domain; Region: rve; pfam00665 656024003872 Integrase core domain; Region: rve_3; pfam13683 656024003873 Homeodomain-like domain; Region: HTH_23; pfam13384 656024003874 Winged helix-turn helix; Region: HTH_29; pfam13551 656024003875 Homeodomain-like domain; Region: HTH_32; pfam13565 656024003876 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024003877 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 656024003878 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 656024003879 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 656024003880 putative NAD(P) binding site [chemical binding]; other site 656024003881 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 656024003882 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 656024003883 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 656024003884 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656024003885 NADH(P)-binding; Region: NAD_binding_10; pfam13460 656024003886 NAD(P) binding site [chemical binding]; other site 656024003887 active site 656024003888 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 656024003889 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 656024003890 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 656024003891 active site 656024003892 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 656024003893 homodimer interface [polypeptide binding]; other site 656024003894 Low molecular weight phosphatase family; Region: LMWPc; cl00105 656024003895 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 656024003896 active site 656024003897 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 656024003898 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 656024003899 Mg++ binding site [ion binding]; other site 656024003900 putative catalytic motif [active] 656024003901 putative substrate binding site [chemical binding]; other site 656024003902 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 656024003903 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 656024003904 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; cl17747 656024003905 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 656024003906 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 656024003907 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 656024003908 nudix motif; other site 656024003909 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 656024003910 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 656024003911 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 656024003912 Phosphoglycerate kinase; Region: PGK; pfam00162 656024003913 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 656024003914 substrate binding site [chemical binding]; other site 656024003915 hinge regions; other site 656024003916 ADP binding site [chemical binding]; other site 656024003917 catalytic site [active] 656024003918 triosephosphate isomerase; Provisional; Region: PRK14567 656024003919 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 656024003920 substrate binding site [chemical binding]; other site 656024003921 dimer interface [polypeptide binding]; other site 656024003922 catalytic triad [active] 656024003923 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 656024003924 peptide binding site [polypeptide binding]; other site 656024003925 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 656024003926 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 656024003927 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 656024003928 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 656024003929 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 656024003930 putative active site [active] 656024003931 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 656024003932 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 656024003933 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 656024003934 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 656024003935 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 656024003936 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 656024003937 putative active site [active] 656024003938 transaldolase; Provisional; Region: PRK03903 656024003939 catalytic residue [active] 656024003940 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 656024003941 UbiA prenyltransferase family; Region: UbiA; pfam01040 656024003942 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 656024003943 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 656024003944 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 656024003945 ABC-2 type transporter; Region: ABC2_membrane; cl17235 656024003946 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 656024003947 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 656024003948 Walker A/P-loop; other site 656024003949 ATP binding site [chemical binding]; other site 656024003950 Q-loop/lid; other site 656024003951 ABC transporter signature motif; other site 656024003952 Walker B; other site 656024003953 D-loop; other site 656024003954 H-loop/switch region; other site 656024003955 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 656024003956 sequence-specific DNA binding site [nucleotide binding]; other site 656024003957 salt bridge; other site 656024003958 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 656024003959 putative DNA binding site [nucleotide binding]; other site 656024003960 dimerization interface [polypeptide binding]; other site 656024003961 Predicted transcriptional regulator [Transcription]; Region: COG2345 656024003962 putative Zn2+ binding site [ion binding]; other site 656024003963 FeS assembly protein SufB; Region: sufB; TIGR01980 656024003964 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 656024003965 FeS assembly protein SufD; Region: sufD; TIGR01981 656024003966 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 656024003967 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 656024003968 [2Fe-2S] cluster binding site [ion binding]; other site 656024003969 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 656024003970 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 656024003971 Walker A/P-loop; other site 656024003972 ATP binding site [chemical binding]; other site 656024003973 Q-loop/lid; other site 656024003974 ABC transporter signature motif; other site 656024003975 Walker B; other site 656024003976 D-loop; other site 656024003977 H-loop/switch region; other site 656024003978 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 656024003979 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 656024003980 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 656024003981 catalytic residue [active] 656024003982 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 656024003983 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 656024003984 trimerization site [polypeptide binding]; other site 656024003985 active site 656024003986 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 656024003987 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 656024003988 putative active site [active] 656024003989 Possible enoyl reductase; Region: MDR_enoyl_red; cd08244 656024003990 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 656024003991 putative NAD(P) binding site [chemical binding]; other site 656024003992 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024003993 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024003994 DNA-binding interface [nucleotide binding]; DNA binding site 656024003995 putative transposase OrfB; Reviewed; Region: PHA02517 656024003996 HTH-like domain; Region: HTH_21; pfam13276 656024003997 Integrase core domain; Region: rve; pfam00665 656024003998 Integrase core domain; Region: rve_3; pfam13683 656024003999 Excalibur calcium-binding domain; Region: Excalibur; smart00894 656024004000 putative transposase OrfB; Reviewed; Region: PHA02517 656024004001 HTH-like domain; Region: HTH_21; pfam13276 656024004002 Integrase core domain; Region: rve; pfam00665 656024004003 Integrase core domain; Region: rve_3; pfam13683 656024004004 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024004005 Transposase; Region: HTH_Tnp_1; pfam01527 656024004006 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 656024004007 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 656024004008 NAD binding site [chemical binding]; other site 656024004009 substrate binding site [chemical binding]; other site 656024004010 homodimer interface [polypeptide binding]; other site 656024004011 active site 656024004012 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 656024004013 LysR substrate binding domain; Region: LysR_substrate; pfam03466 656024004014 dimerization interface [polypeptide binding]; other site 656024004015 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 656024004016 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 656024004017 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 656024004018 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 656024004019 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 656024004020 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 656024004021 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 656024004022 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 656024004023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 656024004024 dimer interface [polypeptide binding]; other site 656024004025 conserved gate region; other site 656024004026 putative PBP binding loops; other site 656024004027 ABC-ATPase subunit interface; other site 656024004028 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 656024004029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 656024004030 ABC-ATPase subunit interface; other site 656024004031 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 656024004032 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 656024004033 Walker A/P-loop; other site 656024004034 ATP binding site [chemical binding]; other site 656024004035 Q-loop/lid; other site 656024004036 ABC transporter signature motif; other site 656024004037 Walker B; other site 656024004038 D-loop; other site 656024004039 H-loop/switch region; other site 656024004040 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 656024004041 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 656024004042 Walker A/P-loop; other site 656024004043 ATP binding site [chemical binding]; other site 656024004044 Q-loop/lid; other site 656024004045 ABC transporter signature motif; other site 656024004046 Walker B; other site 656024004047 D-loop; other site 656024004048 H-loop/switch region; other site 656024004049 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 656024004050 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 656024004051 active site residue [active] 656024004052 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 656024004053 active site residue [active] 656024004054 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 656024004055 putative active site [active] 656024004056 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024004057 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024004058 DNA-binding interface [nucleotide binding]; DNA binding site 656024004059 putative transposase OrfB; Reviewed; Region: PHA02517 656024004060 HTH-like domain; Region: HTH_21; pfam13276 656024004061 Integrase core domain; Region: rve; pfam00665 656024004062 Integrase core domain; Region: rve_3; pfam13683 656024004063 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 656024004064 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 656024004065 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 656024004066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 656024004067 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 656024004068 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 656024004069 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 656024004070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024004071 Walker A/P-loop; other site 656024004072 ATP binding site [chemical binding]; other site 656024004073 Q-loop/lid; other site 656024004074 ABC transporter signature motif; other site 656024004075 Walker B; other site 656024004076 D-loop; other site 656024004077 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 656024004078 Cation efflux family; Region: Cation_efflux; pfam01545 656024004079 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 656024004080 trimer interface [polypeptide binding]; other site 656024004081 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 656024004082 oxyanion hole (OAH) forming residues; other site 656024004083 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 656024004084 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 656024004085 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024004086 Walker A/P-loop; other site 656024004087 ATP binding site [chemical binding]; other site 656024004088 Q-loop/lid; other site 656024004089 ABC transporter signature motif; other site 656024004090 Walker B; other site 656024004091 D-loop; other site 656024004092 H-loop/switch region; other site 656024004093 Homeodomain-like domain; Region: HTH_23; pfam13384 656024004094 Winged helix-turn helix; Region: HTH_29; pfam13551 656024004095 Homeodomain-like domain; Region: HTH_32; pfam13565 656024004096 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024004097 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 656024004098 pyruvate kinase; Provisional; Region: PRK06247 656024004099 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 656024004100 domain interfaces; other site 656024004101 active site 656024004102 hydroxyglutarate oxidase; Provisional; Region: PRK11728 656024004103 Predicted dehydrogenase [General function prediction only]; Region: COG0579 656024004104 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 656024004105 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 656024004106 Homeodomain-like domain; Region: HTH_23; pfam13384 656024004107 Winged helix-turn helix; Region: HTH_29; pfam13551 656024004108 Homeodomain-like domain; Region: HTH_32; pfam13565 656024004109 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024004110 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 656024004111 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 656024004112 TrkA-C domain; Region: TrkA_C; pfam02080 656024004113 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 656024004114 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 656024004115 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 656024004116 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 656024004117 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656024004118 NAD(P) binding site [chemical binding]; other site 656024004119 active site 656024004120 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 656024004121 short chain dehydrogenase; Provisional; Region: PRK07856 656024004122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656024004123 NAD(P) binding site [chemical binding]; other site 656024004124 active site 656024004125 ferrochelatase; Reviewed; Region: hemH; PRK00035 656024004126 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 656024004127 C-terminal domain interface [polypeptide binding]; other site 656024004128 active site 656024004129 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 656024004130 active site 656024004131 N-terminal domain interface [polypeptide binding]; other site 656024004132 conserved hypothetical protein; Region: TIGR03847 656024004133 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 656024004134 active site 656024004135 catalytic triad [active] 656024004136 oxyanion hole [active] 656024004137 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 656024004138 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 656024004139 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 656024004140 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 656024004141 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 656024004142 FAD binding domain; Region: FAD_binding_4; pfam01565 656024004143 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 656024004144 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 656024004145 ATP binding site [chemical binding]; other site 656024004146 Walker B motif; other site 656024004147 arginine finger; other site 656024004148 Peptidase family M41; Region: Peptidase_M41; pfam01434 656024004149 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 656024004150 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 656024004151 urate oxidase; Region: urate_oxi; TIGR03383 656024004152 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 656024004153 active site 656024004154 Bacterial Ig-like domain; Region: Big_5; pfam13205 656024004155 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 656024004156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 656024004157 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 656024004158 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 656024004159 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024004160 Walker A/P-loop; other site 656024004161 ATP binding site [chemical binding]; other site 656024004162 Q-loop/lid; other site 656024004163 ABC transporter signature motif; other site 656024004164 Walker B; other site 656024004165 D-loop; other site 656024004166 H-loop/switch region; other site 656024004167 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 656024004168 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 656024004169 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024004170 Walker A/P-loop; other site 656024004171 ATP binding site [chemical binding]; other site 656024004172 Q-loop/lid; other site 656024004173 ABC transporter signature motif; other site 656024004174 Walker B; other site 656024004175 D-loop; other site 656024004176 H-loop/switch region; other site 656024004177 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 656024004178 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 656024004179 active site 656024004180 iron coordination sites [ion binding]; other site 656024004181 substrate binding pocket [chemical binding]; other site 656024004182 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 656024004183 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 656024004184 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 656024004185 NAD binding site [chemical binding]; other site 656024004186 catalytic Zn binding site [ion binding]; other site 656024004187 substrate binding site [chemical binding]; other site 656024004188 structural Zn binding site [ion binding]; other site 656024004189 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 656024004190 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 656024004191 P-loop; other site 656024004192 Magnesium ion binding site [ion binding]; other site 656024004193 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 656024004194 Magnesium ion binding site [ion binding]; other site 656024004195 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 656024004196 active site 656024004197 Peptidase family M50; Region: Peptidase_M50; pfam02163 656024004198 putative substrate binding region [chemical binding]; other site 656024004199 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 656024004200 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 656024004201 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 656024004202 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 656024004203 active site 656024004204 prephenate dehydrogenase; Validated; Region: PRK08507 656024004205 prephenate dehydrogenase; Validated; Region: PRK06545 656024004206 ACT domain; Region: ACT; pfam01842 656024004207 cytidylate kinase; Provisional; Region: cmk; PRK00023 656024004208 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 656024004209 CMP-binding site; other site 656024004210 The sites determining sugar specificity; other site 656024004211 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 656024004212 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 656024004213 putative acyl-acceptor binding pocket; other site 656024004214 GTP-binding protein Der; Reviewed; Region: PRK03003 656024004215 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 656024004216 G1 box; other site 656024004217 GTP/Mg2+ binding site [chemical binding]; other site 656024004218 Switch I region; other site 656024004219 G2 box; other site 656024004220 Switch II region; other site 656024004221 G3 box; other site 656024004222 G4 box; other site 656024004223 G5 box; other site 656024004224 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 656024004225 G1 box; other site 656024004226 GTP/Mg2+ binding site [chemical binding]; other site 656024004227 Switch I region; other site 656024004228 G2 box; other site 656024004229 G3 box; other site 656024004230 Switch II region; other site 656024004231 G4 box; other site 656024004232 G5 box; other site 656024004233 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 656024004234 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 656024004235 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 656024004236 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 656024004237 active site 656024004238 putative catalytic site [active] 656024004239 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 656024004240 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 656024004241 active site 656024004242 HIGH motif; other site 656024004243 nucleotide binding site [chemical binding]; other site 656024004244 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 656024004245 active site 656024004246 KMSKS motif; other site 656024004247 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 656024004248 tRNA binding surface [nucleotide binding]; other site 656024004249 anticodon binding site; other site 656024004250 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 656024004251 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 656024004252 active site 656024004253 dimerization interface [polypeptide binding]; other site 656024004254 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 656024004255 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 656024004256 trimer interface [polypeptide binding]; other site 656024004257 putative metal binding site [ion binding]; other site 656024004258 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 656024004259 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 656024004260 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 656024004261 trimer interface [polypeptide binding]; other site 656024004262 active site 656024004263 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 656024004264 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 656024004265 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 656024004266 TRAM domain; Region: TRAM; pfam01938 656024004267 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 656024004268 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 656024004269 TPP-binding site; other site 656024004270 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 656024004271 PYR/PP interface [polypeptide binding]; other site 656024004272 dimer interface [polypeptide binding]; other site 656024004273 TPP binding site [chemical binding]; other site 656024004274 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 656024004275 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 656024004276 putative hydrophobic ligand binding site [chemical binding]; other site 656024004277 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 656024004278 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 656024004279 substrate binding site [chemical binding]; other site 656024004280 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 656024004281 oxyanion hole (OAH) forming residues; other site 656024004282 trimer interface [polypeptide binding]; other site 656024004283 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 656024004284 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 656024004285 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 656024004286 dimer interface [polypeptide binding]; other site 656024004287 active site 656024004288 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 656024004289 catalytic site [active] 656024004290 putative active site [active] 656024004291 putative substrate binding site [chemical binding]; other site 656024004292 Helicase and RNase D C-terminal; Region: HRDC; smart00341 656024004293 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 656024004294 integral membrane protein; Region: integ_memb_HG; TIGR03954 656024004295 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 656024004296 substrate binding site [chemical binding]; other site 656024004297 active site 656024004298 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 656024004299 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 656024004300 Methyltransferase domain; Region: Methyltransf_23; pfam13489 656024004301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 656024004302 S-adenosylmethionine binding site [chemical binding]; other site 656024004303 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 656024004304 transmembrane helices; other site 656024004305 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 656024004306 potential frameshift: common BLAST hit: gi|315505761|ref|YP_004084648.1| WD40 repeat-containing protein 656024004307 NACHT domain; Region: NACHT; pfam05729 656024004308 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 656024004309 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 656024004310 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 656024004311 structural tetrad; other site 656024004312 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 656024004313 structural tetrad; other site 656024004314 FOG: WD40 repeat [General function prediction only]; Region: COG2319 656024004315 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 656024004316 structural tetrad; other site 656024004317 TIR domain; Region: TIR_2; pfam13676 656024004318 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 656024004319 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 656024004320 SEFIR domain; Region: SEFIR; pfam08357 656024004321 TIR domain; Region: TIR_2; pfam13676 656024004322 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 656024004323 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 656024004324 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 656024004325 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 656024004326 structural tetrad; other site 656024004327 FOG: WD40 repeat [General function prediction only]; Region: COG2319 656024004328 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 656024004329 structural tetrad; other site 656024004330 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 656024004331 structural tetrad; other site 656024004332 FOG: WD40 repeat [General function prediction only]; Region: COG2319 656024004333 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 656024004334 substrate binding site [chemical binding]; other site 656024004335 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 656024004336 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 656024004337 Winged helix-turn helix; Region: HTH_29; pfam13551 656024004338 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024004339 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 656024004340 classical (c) SDRs; Region: SDR_c; cd05233 656024004341 NAD(P) binding site [chemical binding]; other site 656024004342 active site 656024004343 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 656024004344 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 656024004345 ligand-binding site [chemical binding]; other site 656024004346 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 656024004347 active site 656024004348 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 656024004349 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 656024004350 Active Sites [active] 656024004351 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 656024004352 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 656024004353 CysD dimerization site [polypeptide binding]; other site 656024004354 G1 box; other site 656024004355 putative GEF interaction site [polypeptide binding]; other site 656024004356 GTP/Mg2+ binding site [chemical binding]; other site 656024004357 Switch I region; other site 656024004358 G2 box; other site 656024004359 G3 box; other site 656024004360 Switch II region; other site 656024004361 G4 box; other site 656024004362 G5 box; other site 656024004363 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 656024004364 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 656024004365 hypothetical protein; Provisional; Region: PRK14059 656024004366 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 656024004367 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 656024004368 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 656024004369 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 656024004370 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 656024004371 catalytic site [active] 656024004372 active site 656024004373 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 656024004374 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 656024004375 catalytic core [active] 656024004376 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 656024004377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 656024004378 dimer interface [polypeptide binding]; other site 656024004379 conserved gate region; other site 656024004380 putative PBP binding loops; other site 656024004381 ABC-ATPase subunit interface; other site 656024004382 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 656024004383 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 656024004384 membrane-bound complex binding site; other site 656024004385 hinge residues; other site 656024004386 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 656024004387 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 656024004388 Walker A/P-loop; other site 656024004389 ATP binding site [chemical binding]; other site 656024004390 Q-loop/lid; other site 656024004391 ABC transporter signature motif; other site 656024004392 Walker B; other site 656024004393 D-loop; other site 656024004394 H-loop/switch region; other site 656024004395 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 656024004396 active site 656024004397 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 656024004398 catalytic tetrad [active] 656024004399 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 656024004400 diaminopimelate decarboxylase; Region: lysA; TIGR01048 656024004401 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 656024004402 active site 656024004403 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 656024004404 substrate binding site [chemical binding]; other site 656024004405 catalytic residues [active] 656024004406 dimer interface [polypeptide binding]; other site 656024004407 hypothetical protein; Provisional; Region: PRK07206 656024004408 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 656024004409 B12 binding domain; Region: B12-binding; pfam02310 656024004410 B12 binding site [chemical binding]; other site 656024004411 Radical SAM superfamily; Region: Radical_SAM; pfam04055 656024004412 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 656024004413 B12 binding site [chemical binding]; other site 656024004414 Radical SAM superfamily; Region: Radical_SAM; pfam04055 656024004415 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 656024004416 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 656024004417 acyl-activating enzyme (AAE) consensus motif; other site 656024004418 AMP binding site [chemical binding]; other site 656024004419 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 656024004420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656024004421 NAD(P) binding site [chemical binding]; other site 656024004422 active site 656024004423 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 656024004424 active site clefts [active] 656024004425 zinc binding site [ion binding]; other site 656024004426 dimer interface [polypeptide binding]; other site 656024004427 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 656024004428 dinuclear metal binding motif [ion binding]; other site 656024004429 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 656024004430 dinuclear metal binding motif [ion binding]; other site 656024004431 Transcriptional regulators [Transcription]; Region: MarR; COG1846 656024004432 MarR family; Region: MarR_2; pfam12802 656024004433 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 656024004434 dimerization interface [polypeptide binding]; other site 656024004435 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 656024004436 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 656024004437 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 656024004438 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 656024004439 Walker A/P-loop; other site 656024004440 ATP binding site [chemical binding]; other site 656024004441 Q-loop/lid; other site 656024004442 ABC transporter signature motif; other site 656024004443 Walker B; other site 656024004444 D-loop; other site 656024004445 H-loop/switch region; other site 656024004446 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 656024004447 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 656024004448 intersubunit interface [polypeptide binding]; other site 656024004449 H+ Antiporter protein; Region: 2A0121; TIGR00900 656024004450 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 656024004451 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 656024004452 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 656024004453 YcaO-like family; Region: YcaO; pfam02624 656024004454 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 656024004455 YcaO-like family; Region: YcaO; pfam02624 656024004456 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 656024004457 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 656024004458 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 656024004459 active site 656024004460 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 656024004461 putative FMN binding site [chemical binding]; other site 656024004462 NADPH bind site [chemical binding]; other site 656024004463 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 656024004464 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 656024004465 P-loop; other site 656024004466 YibE/F-like protein; Region: YibE_F; pfam07907 656024004467 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 656024004468 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 656024004469 NAD(P) binding site [chemical binding]; other site 656024004470 catalytic residues [active] 656024004471 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 656024004472 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 656024004473 dimer interface [polypeptide binding]; other site 656024004474 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 656024004475 active site 656024004476 Fe binding site [ion binding]; other site 656024004477 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 656024004478 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 656024004479 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 656024004480 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 656024004481 Winged helix-turn helix; Region: HTH_29; pfam13551 656024004482 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024004483 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 656024004484 putative active site [active] 656024004485 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 656024004486 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 656024004487 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 656024004488 TrkA-N domain; Region: TrkA_N; pfam02254 656024004489 TrkA-C domain; Region: TrkA_C; pfam02080 656024004490 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 656024004491 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 656024004492 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 656024004493 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 656024004494 Clp amino terminal domain; Region: Clp_N; pfam02861 656024004495 Clp amino terminal domain; Region: Clp_N; pfam02861 656024004496 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656024004497 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024004498 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 656024004499 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 656024004500 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 656024004501 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 656024004502 FMN-binding pocket [chemical binding]; other site 656024004503 flavin binding motif; other site 656024004504 phosphate binding motif [ion binding]; other site 656024004505 beta-alpha-beta structure motif; other site 656024004506 NAD binding pocket [chemical binding]; other site 656024004507 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 656024004508 catalytic loop [active] 656024004509 iron binding site [ion binding]; other site 656024004510 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 656024004511 active site 656024004512 short chain dehydrogenase; Validated; Region: PRK05855 656024004513 classical (c) SDRs; Region: SDR_c; cd05233 656024004514 NAD(P) binding site [chemical binding]; other site 656024004515 active site 656024004516 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 656024004517 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 656024004518 FAD binding pocket [chemical binding]; other site 656024004519 FAD binding motif [chemical binding]; other site 656024004520 phosphate binding motif [ion binding]; other site 656024004521 beta-alpha-beta structure motif; other site 656024004522 NAD binding pocket [chemical binding]; other site 656024004523 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 656024004524 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 656024004525 catalytic loop [active] 656024004526 iron binding site [ion binding]; other site 656024004527 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 656024004528 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 656024004529 putative di-iron ligands [ion binding]; other site 656024004530 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 656024004531 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 656024004532 classical (c) SDRs; Region: SDR_c; cd05233 656024004533 NAD(P) binding site [chemical binding]; other site 656024004534 active site 656024004535 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 656024004536 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 656024004537 Walker A/P-loop; other site 656024004538 ATP binding site [chemical binding]; other site 656024004539 Q-loop/lid; other site 656024004540 ABC transporter signature motif; other site 656024004541 Walker B; other site 656024004542 D-loop; other site 656024004543 H-loop/switch region; other site 656024004544 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 656024004545 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 656024004546 TM-ABC transporter signature motif; other site 656024004547 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 656024004548 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 656024004549 TM-ABC transporter signature motif; other site 656024004550 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 656024004551 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 656024004552 Walker A/P-loop; other site 656024004553 ATP binding site [chemical binding]; other site 656024004554 Q-loop/lid; other site 656024004555 ABC transporter signature motif; other site 656024004556 Walker B; other site 656024004557 D-loop; other site 656024004558 H-loop/switch region; other site 656024004559 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 656024004560 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 656024004561 putative ligand binding site [chemical binding]; other site 656024004562 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 656024004563 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 656024004564 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 656024004565 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 656024004566 Walker A/P-loop; other site 656024004567 ATP binding site [chemical binding]; other site 656024004568 Q-loop/lid; other site 656024004569 ABC transporter signature motif; other site 656024004570 Walker B; other site 656024004571 D-loop; other site 656024004572 H-loop/switch region; other site 656024004573 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 656024004574 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 656024004575 Walker A/P-loop; other site 656024004576 ATP binding site [chemical binding]; other site 656024004577 Q-loop/lid; other site 656024004578 ABC transporter signature motif; other site 656024004579 Walker B; other site 656024004580 D-loop; other site 656024004581 H-loop/switch region; other site 656024004582 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 656024004583 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 656024004584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 656024004585 dimer interface [polypeptide binding]; other site 656024004586 conserved gate region; other site 656024004587 ABC-ATPase subunit interface; other site 656024004588 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 656024004589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 656024004590 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 656024004591 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 656024004592 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 656024004593 active site 656024004594 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 656024004595 non-prolyl cis peptide bond; other site 656024004596 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 656024004597 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 656024004598 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656024004599 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024004600 Homeodomain-like domain; Region: HTH_23; pfam13384 656024004601 Winged helix-turn helix; Region: HTH_29; pfam13551 656024004602 Homeodomain-like domain; Region: HTH_32; pfam13565 656024004603 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024004604 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 656024004605 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024004606 putative substrate translocation pore; other site 656024004607 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 656024004608 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 656024004609 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 656024004610 Cytochrome P450; Region: p450; cl12078 656024004611 Winged helix-turn helix; Region: HTH_29; pfam13551 656024004612 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024004613 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 656024004614 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 656024004615 Thioesterase domain; Region: Thioesterase; pfam00975 656024004616 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 656024004617 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 656024004618 active site 656024004619 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 656024004620 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 656024004621 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 656024004622 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 656024004623 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 656024004624 active site 656024004625 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 656024004626 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 656024004627 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 656024004628 putative NADP binding site [chemical binding]; other site 656024004629 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 656024004630 active site 656024004631 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 656024004632 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 656024004633 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 656024004634 active site 656024004635 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 656024004636 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 656024004637 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 656024004638 putative NADP binding site [chemical binding]; other site 656024004639 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 656024004640 active site 656024004641 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 656024004642 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 656024004643 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 656024004644 active site 656024004645 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 656024004646 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 656024004647 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 656024004648 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 656024004649 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 656024004650 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 656024004651 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 656024004652 active site 656024004653 hypothetical protein; Provisional; Region: PRK08244 656024004654 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 656024004655 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 656024004656 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 656024004657 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 656024004658 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 656024004659 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 656024004660 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 656024004661 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 656024004662 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 656024004663 DNA binding residues [nucleotide binding] 656024004664 dimerization interface [polypeptide binding]; other site 656024004665 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656024004666 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024004667 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 656024004668 DNA binding residues [nucleotide binding] 656024004669 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 656024004670 DNA binding site [nucleotide binding] 656024004671 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 656024004672 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 656024004673 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 656024004674 active site 656024004675 FMN binding site [chemical binding]; other site 656024004676 substrate binding site [chemical binding]; other site 656024004677 3Fe-4S cluster binding site [ion binding]; other site 656024004678 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 656024004679 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 656024004680 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 656024004681 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 656024004682 Acid Phosphatase; Region: Acid_PPase; cl17256 656024004683 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 656024004684 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 656024004685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024004686 putative substrate translocation pore; other site 656024004687 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656024004688 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024004689 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 656024004690 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 656024004691 active site 656024004692 non-prolyl cis peptide bond; other site 656024004693 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 656024004694 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 656024004695 Walker A/P-loop; other site 656024004696 ATP binding site [chemical binding]; other site 656024004697 Q-loop/lid; other site 656024004698 ABC transporter signature motif; other site 656024004699 Walker B; other site 656024004700 D-loop; other site 656024004701 H-loop/switch region; other site 656024004702 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 656024004703 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 656024004704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 656024004705 dimer interface [polypeptide binding]; other site 656024004706 conserved gate region; other site 656024004707 putative PBP binding loops; other site 656024004708 ABC-ATPase subunit interface; other site 656024004709 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 656024004710 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 656024004711 Walker A/P-loop; other site 656024004712 ATP binding site [chemical binding]; other site 656024004713 Q-loop/lid; other site 656024004714 ABC transporter signature motif; other site 656024004715 Walker B; other site 656024004716 D-loop; other site 656024004717 H-loop/switch region; other site 656024004718 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 656024004719 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 656024004720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 656024004721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 656024004722 putative PBP binding loops; other site 656024004723 dimer interface [polypeptide binding]; other site 656024004724 ABC-ATPase subunit interface; other site 656024004725 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024004726 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024004727 DNA-binding interface [nucleotide binding]; DNA binding site 656024004728 putative transposase OrfB; Reviewed; Region: PHA02517 656024004729 HTH-like domain; Region: HTH_21; pfam13276 656024004730 Integrase core domain; Region: rve; pfam00665 656024004731 Integrase core domain; Region: rve_3; pfam13683 656024004732 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 656024004733 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 656024004734 motif II; other site 656024004735 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 656024004736 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 656024004737 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 656024004738 TMP-binding site; other site 656024004739 ATP-binding site [chemical binding]; other site 656024004740 Helix-turn-helix domain; Region: HTH_17; pfam12728 656024004741 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 656024004742 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 656024004743 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 656024004744 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 656024004745 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 656024004746 dimerization interface [polypeptide binding]; other site 656024004747 NAD binding site [chemical binding]; other site 656024004748 ligand binding site [chemical binding]; other site 656024004749 catalytic site [active] 656024004750 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 656024004751 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 656024004752 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024004753 Walker A/P-loop; other site 656024004754 ATP binding site [chemical binding]; other site 656024004755 Q-loop/lid; other site 656024004756 ABC transporter signature motif; other site 656024004757 Walker B; other site 656024004758 D-loop; other site 656024004759 H-loop/switch region; other site 656024004760 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 656024004761 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 656024004762 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 656024004763 Walker A/P-loop; other site 656024004764 ATP binding site [chemical binding]; other site 656024004765 Q-loop/lid; other site 656024004766 ABC transporter signature motif; other site 656024004767 Walker B; other site 656024004768 D-loop; other site 656024004769 H-loop/switch region; other site 656024004770 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024004771 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024004772 DNA-binding interface [nucleotide binding]; DNA binding site 656024004773 putative transposase OrfB; Reviewed; Region: PHA02517 656024004774 HTH-like domain; Region: HTH_21; pfam13276 656024004775 Integrase core domain; Region: rve; pfam00665 656024004776 Integrase core domain; Region: rve_3; pfam13683 656024004777 TIR domain; Region: TIR_2; pfam13676 656024004778 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 656024004779 nucleotide binding site/active site [active] 656024004780 HIT family signature motif; other site 656024004781 catalytic residue [active] 656024004782 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 656024004783 putative active site [active] 656024004784 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024004785 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024004786 DNA-binding interface [nucleotide binding]; DNA binding site 656024004787 putative transposase OrfB; Reviewed; Region: PHA02517 656024004788 HTH-like domain; Region: HTH_21; pfam13276 656024004789 Integrase core domain; Region: rve; pfam00665 656024004790 Integrase core domain; Region: rve_3; pfam13683 656024004791 putative transposase OrfB; Reviewed; Region: PHA02517 656024004792 HTH-like domain; Region: HTH_21; pfam13276 656024004793 Integrase core domain; Region: rve; pfam00665 656024004794 Integrase core domain; Region: rve_3; pfam13683 656024004795 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024004796 Transposase; Region: HTH_Tnp_1; pfam01527 656024004797 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 656024004798 Clp protease; Region: CLP_protease; pfam00574 656024004799 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 656024004800 oligomer interface [polypeptide binding]; other site 656024004801 active site residues [active] 656024004802 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 656024004803 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 656024004804 sequence-specific DNA binding site [nucleotide binding]; other site 656024004805 salt bridge; other site 656024004806 PAS domain; Region: PAS_9; pfam13426 656024004807 PAS fold; Region: PAS_4; pfam08448 656024004808 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656024004809 putative active site [active] 656024004810 heme pocket [chemical binding]; other site 656024004811 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 656024004812 GAF domain; Region: GAF; pfam01590 656024004813 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 656024004814 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 656024004815 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656024004816 Mg2+ binding site [ion binding]; other site 656024004817 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 656024004818 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 656024004819 active site 656024004820 non-prolyl cis peptide bond; other site 656024004821 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 656024004822 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 656024004823 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 656024004824 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 656024004825 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 656024004826 homodimer interface [polypeptide binding]; other site 656024004827 substrate-cofactor binding pocket; other site 656024004828 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656024004829 catalytic residue [active] 656024004830 hypothetical protein; Provisional; Region: PRK07208 656024004831 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 656024004832 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 656024004833 GAF domain; Region: GAF_2; pfam13185 656024004834 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 656024004835 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 656024004836 DNA binding residues [nucleotide binding] 656024004837 dimerization interface [polypeptide binding]; other site 656024004838 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 656024004839 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 656024004840 dimer interface [polypeptide binding]; other site 656024004841 acyl-activating enzyme (AAE) consensus motif; other site 656024004842 putative active site [active] 656024004843 AMP binding site [chemical binding]; other site 656024004844 putative CoA binding site [chemical binding]; other site 656024004845 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 656024004846 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 656024004847 GAF domain; Region: GAF; pfam01590 656024004848 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 656024004849 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 656024004850 DNA binding residues [nucleotide binding] 656024004851 dimerization interface [polypeptide binding]; other site 656024004852 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 656024004853 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 656024004854 NAD(P) binding site [chemical binding]; other site 656024004855 enoyl-CoA hydratase; Provisional; Region: PRK06688 656024004856 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 656024004857 substrate binding site [chemical binding]; other site 656024004858 oxyanion hole (OAH) forming residues; other site 656024004859 trimer interface [polypeptide binding]; other site 656024004860 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 656024004861 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 656024004862 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 656024004863 acyl-activating enzyme (AAE) consensus motif; other site 656024004864 putative AMP binding site [chemical binding]; other site 656024004865 putative active site [active] 656024004866 putative CoA binding site [chemical binding]; other site 656024004867 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 656024004868 active site 2 [active] 656024004869 active site 1 [active] 656024004870 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 656024004871 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 656024004872 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 656024004873 active site 656024004874 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 656024004875 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 656024004876 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 656024004877 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 656024004878 acyl-activating enzyme (AAE) consensus motif; other site 656024004879 AMP binding site [chemical binding]; other site 656024004880 active site 656024004881 CoA binding site [chemical binding]; other site 656024004882 Transcriptional regulators [Transcription]; Region: FadR; COG2186 656024004883 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 656024004884 DNA-binding site [nucleotide binding]; DNA binding site 656024004885 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 656024004886 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 656024004887 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 656024004888 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 656024004889 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 656024004890 active site 656024004891 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 656024004892 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656024004893 NAD(P) binding site [chemical binding]; other site 656024004894 active site 656024004895 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 656024004896 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 656024004897 dimer interface [polypeptide binding]; other site 656024004898 active site 656024004899 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 656024004900 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 656024004901 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 656024004902 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 656024004903 active site 656024004904 catalytic residues [active] 656024004905 metal binding site [ion binding]; metal-binding site 656024004906 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase; Region: benzo_BadH; TIGR03206 656024004907 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656024004908 NAD(P) binding site [chemical binding]; other site 656024004909 active site 656024004910 enoyl-CoA hydratase; Provisional; Region: PRK07658 656024004911 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 656024004912 substrate binding site [chemical binding]; other site 656024004913 oxyanion hole (OAH) forming residues; other site 656024004914 trimer interface [polypeptide binding]; other site 656024004915 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 656024004916 Homeodomain-like domain; Region: HTH_23; pfam13384 656024004917 Winged helix-turn helix; Region: HTH_29; pfam13551 656024004918 Homeodomain-like domain; Region: HTH_32; pfam13565 656024004919 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 656024004920 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 656024004921 substrate binding site [chemical binding]; other site 656024004922 oxyanion hole (OAH) forming residues; other site 656024004923 trimer interface [polypeptide binding]; other site 656024004924 enoyl-CoA hydratase; Provisional; Region: PRK06688 656024004925 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 656024004926 substrate binding site [chemical binding]; other site 656024004927 oxyanion hole (OAH) forming residues; other site 656024004928 trimer interface [polypeptide binding]; other site 656024004929 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 656024004930 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 656024004931 NAD(P) binding site [chemical binding]; other site 656024004932 short chain dehydrogenase; Provisional; Region: PRK07677 656024004933 substrate binding site [chemical binding]; other site 656024004934 homotetramer interface [polypeptide binding]; other site 656024004935 active site 656024004936 homodimer interface [polypeptide binding]; other site 656024004937 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 656024004938 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 656024004939 substrate binding site [chemical binding]; other site 656024004940 oxyanion hole (OAH) forming residues; other site 656024004941 trimer interface [polypeptide binding]; other site 656024004942 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 656024004943 Cytochrome P450; Region: p450; cl12078 656024004944 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 656024004945 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 656024004946 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 656024004947 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 656024004948 catalytic loop [active] 656024004949 iron binding site [ion binding]; other site 656024004950 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 656024004951 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 656024004952 catalytic Zn binding site [ion binding]; other site 656024004953 NAD binding site [chemical binding]; other site 656024004954 structural Zn binding site [ion binding]; other site 656024004955 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 656024004956 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 656024004957 NAD binding site [chemical binding]; other site 656024004958 catalytic residues [active] 656024004959 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 656024004960 Transcriptional regulators [Transcription]; Region: FadR; COG2186 656024004961 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 656024004962 DNA-binding site [nucleotide binding]; DNA binding site 656024004963 FCD domain; Region: FCD; pfam07729 656024004964 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 656024004965 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 656024004966 active site 656024004967 metal binding site [ion binding]; metal-binding site 656024004968 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 656024004969 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 656024004970 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 656024004971 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 656024004972 [2Fe-2S] cluster binding site [ion binding]; other site 656024004973 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 656024004974 putative alpha subunit interface [polypeptide binding]; other site 656024004975 putative active site [active] 656024004976 putative substrate binding site [chemical binding]; other site 656024004977 Fe binding site [ion binding]; other site 656024004978 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 656024004979 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 656024004980 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656024004981 NAD(P) binding site [chemical binding]; other site 656024004982 active site 656024004983 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 656024004984 acetaldehyde dehydrogenase; Validated; Region: PRK08300 656024004985 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 656024004986 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 656024004987 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 656024004988 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 656024004989 active site 656024004990 catalytic residues [active] 656024004991 metal binding site [ion binding]; metal-binding site 656024004992 DmpG-like communication domain; Region: DmpG_comm; pfam07836 656024004993 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 656024004994 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 656024004995 acyl-activating enzyme (AAE) consensus motif; other site 656024004996 AMP binding site [chemical binding]; other site 656024004997 active site 656024004998 CoA binding site [chemical binding]; other site 656024004999 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 656024005000 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 656024005001 DNA binding residues [nucleotide binding] 656024005002 dimerization interface [polypeptide binding]; other site 656024005003 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 656024005004 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 656024005005 active site 656024005006 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 656024005007 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 656024005008 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 656024005009 Permease; Region: Permease; pfam02405 656024005010 Permease; Region: Permease; pfam02405 656024005011 Homeodomain-like domain; Region: HTH_23; pfam13384 656024005012 Winged helix-turn helix; Region: HTH_29; pfam13551 656024005013 Homeodomain-like domain; Region: HTH_32; pfam13565 656024005014 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024005015 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 656024005016 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 656024005017 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 656024005018 substrate binding site [chemical binding]; other site 656024005019 oxyanion hole (OAH) forming residues; other site 656024005020 trimer interface [polypeptide binding]; other site 656024005021 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024005022 acyl-CoA synthetase; Validated; Region: PRK08316 656024005023 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 656024005024 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 656024005025 acyl-activating enzyme (AAE) consensus motif; other site 656024005026 putative AMP binding site [chemical binding]; other site 656024005027 putative active site [active] 656024005028 putative CoA binding site [chemical binding]; other site 656024005029 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 656024005030 Permease; Region: Permease; pfam02405 656024005031 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 656024005032 Permease; Region: Permease; pfam02405 656024005033 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 656024005034 mce related protein; Region: MCE; pfam02470 656024005035 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 656024005036 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 656024005037 mce related protein; Region: MCE; pfam02470 656024005038 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 656024005039 mce related protein; Region: MCE; pfam02470 656024005040 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 656024005041 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 656024005042 mce related protein; Region: MCE; pfam02470 656024005043 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 656024005044 mce related protein; Region: MCE; pfam02470 656024005045 The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Region: 2A067; TIGR00921 656024005046 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 656024005047 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 656024005048 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 656024005049 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 656024005050 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 656024005051 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656024005052 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024005053 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656024005054 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024005055 GAF domain; Region: GAF; cl17456 656024005056 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 656024005057 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 656024005058 DNA binding residues [nucleotide binding] 656024005059 dimerization interface [polypeptide binding]; other site 656024005060 GAF domain; Region: GAF; pfam01590 656024005061 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 656024005062 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 656024005063 DNA binding residues [nucleotide binding] 656024005064 dimerization interface [polypeptide binding]; other site 656024005065 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 656024005066 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 656024005067 active site 656024005068 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 656024005069 FMN binding site [chemical binding]; other site 656024005070 substrate binding site [chemical binding]; other site 656024005071 putative catalytic residue [active] 656024005072 acyl-CoA synthetase; Validated; Region: PRK06188 656024005073 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 656024005074 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 656024005075 acyl-activating enzyme (AAE) consensus motif; other site 656024005076 putative AMP binding site [chemical binding]; other site 656024005077 putative active site [active] 656024005078 putative CoA binding site [chemical binding]; other site 656024005079 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 656024005080 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 656024005081 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 656024005082 NAD(P) binding site [chemical binding]; other site 656024005083 catalytic residues [active] 656024005084 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 656024005085 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 656024005086 dimer interface [polypeptide binding]; other site 656024005087 active site 656024005088 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 656024005089 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 656024005090 substrate binding site [chemical binding]; other site 656024005091 oxyanion hole (OAH) forming residues; other site 656024005092 trimer interface [polypeptide binding]; other site 656024005093 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 656024005094 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 656024005095 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 656024005096 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 656024005097 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 656024005098 active site 656024005099 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 656024005100 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 656024005101 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 656024005102 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 656024005103 ATP-grasp domain; Region: ATP-grasp_4; cl17255 656024005104 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 656024005105 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 656024005106 carboxyltransferase (CT) interaction site; other site 656024005107 biotinylation site [posttranslational modification]; other site 656024005108 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 656024005109 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 656024005110 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 656024005111 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 656024005112 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024005113 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656024005114 DNA-binding interface [nucleotide binding]; DNA binding site 656024005115 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 656024005116 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 656024005117 putative transposase OrfB; Reviewed; Region: PHA02517 656024005118 HTH-like domain; Region: HTH_21; pfam13276 656024005119 Integrase core domain; Region: rve; pfam00665 656024005120 Integrase core domain; Region: rve_3; pfam13683 656024005121 N-acyltransferase NodA; Region: nodulat_NodA; TIGR04245 656024005122 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 656024005123 chitooligosaccharide deacetylase NodB; Region: nodulat_NodB; TIGR04243 656024005124 Nodulation protein A (NodA); Region: NodA; cl17421 656024005125 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 656024005126 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 656024005127 inhibitor-cofactor binding pocket; inhibition site 656024005128 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656024005129 catalytic residue [active] 656024005130 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 656024005131 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 656024005132 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 656024005133 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 656024005134 putative active site [active] 656024005135 putative NTP binding site [chemical binding]; other site 656024005136 putative nucleic acid binding site [nucleotide binding]; other site 656024005137 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 656024005138 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024005139 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024005140 DNA-binding interface [nucleotide binding]; DNA binding site 656024005141 putative transposase OrfB; Reviewed; Region: PHA02517 656024005142 HTH-like domain; Region: HTH_21; pfam13276 656024005143 Integrase core domain; Region: rve; pfam00665 656024005144 Integrase core domain; Region: rve_3; pfam13683 656024005145 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024005146 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024005147 DNA-binding interface [nucleotide binding]; DNA binding site 656024005148 putative transposase OrfB; Reviewed; Region: PHA02517 656024005149 HTH-like domain; Region: HTH_21; pfam13276 656024005150 Integrase core domain; Region: rve; pfam00665 656024005151 Integrase core domain; Region: rve_3; pfam13683 656024005152 Homeodomain-like domain; Region: HTH_23; pfam13384 656024005153 Winged helix-turn helix; Region: HTH_29; pfam13551 656024005154 Homeodomain-like domain; Region: HTH_32; pfam13565 656024005155 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024005156 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 656024005157 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 656024005158 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 656024005159 catalytic residues [active] 656024005160 catalytic nucleophile [active] 656024005161 Recombinase; Region: Recombinase; pfam07508 656024005162 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 656024005163 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 656024005164 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 656024005165 active site 656024005166 phosphorylation site [posttranslational modification] 656024005167 intermolecular recognition site; other site 656024005168 dimerization interface [polypeptide binding]; other site 656024005169 ANTAR domain; Region: ANTAR; pfam03861 656024005170 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 656024005171 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 656024005172 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 656024005173 MMPL family; Region: MMPL; pfam03176 656024005174 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656024005175 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024005176 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 656024005177 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 656024005178 active site 656024005179 metal binding site [ion binding]; metal-binding site 656024005180 nudix motif; other site 656024005181 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 656024005182 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 656024005183 substrate binding site [chemical binding]; other site 656024005184 oxyanion hole (OAH) forming residues; other site 656024005185 trimer interface [polypeptide binding]; other site 656024005186 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 656024005187 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 656024005188 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 656024005189 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 656024005190 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 656024005191 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 656024005192 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 656024005193 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 656024005194 GAF domain; Region: GAF_3; pfam13492 656024005195 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 656024005196 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 656024005197 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 656024005198 Mg2+ binding site [ion binding]; other site 656024005199 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656024005200 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024005201 MASE1; Region: MASE1; cl17823 656024005202 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 656024005203 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 656024005204 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 656024005205 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 656024005206 active site 656024005207 metal binding site [ion binding]; metal-binding site 656024005208 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 656024005209 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 656024005210 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 656024005211 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 656024005212 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 656024005213 active site 656024005214 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 656024005215 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 656024005216 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 656024005217 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 656024005218 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 656024005219 dimerization interface [polypeptide binding]; other site 656024005220 ligand binding site [chemical binding]; other site 656024005221 Homeodomain-like domain; Region: HTH_23; pfam13384 656024005222 Winged helix-turn helix; Region: HTH_29; pfam13551 656024005223 Homeodomain-like domain; Region: HTH_32; pfam13565 656024005224 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024005225 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 656024005226 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 656024005227 CoenzymeA binding site [chemical binding]; other site 656024005228 subunit interaction site [polypeptide binding]; other site 656024005229 PHB binding site; other site 656024005230 DNA polymerase I; Provisional; Region: PRK05755 656024005231 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 656024005232 active site 656024005233 metal binding site 1 [ion binding]; metal-binding site 656024005234 putative 5' ssDNA interaction site; other site 656024005235 metal binding site 3; metal-binding site 656024005236 metal binding site 2 [ion binding]; metal-binding site 656024005237 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 656024005238 putative DNA binding site [nucleotide binding]; other site 656024005239 putative metal binding site [ion binding]; other site 656024005240 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 656024005241 active site 656024005242 catalytic site [active] 656024005243 substrate binding site [chemical binding]; other site 656024005244 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 656024005245 active site 656024005246 DNA binding site [nucleotide binding] 656024005247 catalytic site [active] 656024005248 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656024005249 metal binding site [ion binding]; metal-binding site 656024005250 active site 656024005251 I-site; other site 656024005252 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 656024005253 GAF domain; Region: GAF; pfam01590 656024005254 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 656024005255 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 656024005256 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 656024005257 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 656024005258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 656024005259 S-adenosylmethionine binding site [chemical binding]; other site 656024005260 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 656024005261 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 656024005262 RNA binding site [nucleotide binding]; other site 656024005263 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 656024005264 RNA binding site [nucleotide binding]; other site 656024005265 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 656024005266 RNA binding site [nucleotide binding]; other site 656024005267 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 656024005268 RNA binding site [nucleotide binding]; other site 656024005269 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 656024005270 Short C-terminal domain; Region: SHOCT; pfam09851 656024005271 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 656024005272 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 656024005273 CoA-binding site [chemical binding]; other site 656024005274 ATP-binding [chemical binding]; other site 656024005275 excinuclease ABC subunit B; Provisional; Region: PRK05298 656024005276 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 656024005277 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 656024005278 nucleotide binding region [chemical binding]; other site 656024005279 ATP-binding site [chemical binding]; other site 656024005280 Ultra-violet resistance protein B; Region: UvrB; pfam12344 656024005281 UvrB/uvrC motif; Region: UVR; pfam02151 656024005282 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 656024005283 ParB-like nuclease domain; Region: ParB; smart00470 656024005284 Methyltransferase domain; Region: Methyltransf_23; pfam13489 656024005285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 656024005286 S-adenosylmethionine binding site [chemical binding]; other site 656024005287 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 656024005288 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 656024005289 substrate binding site [chemical binding]; other site 656024005290 ATP binding site [chemical binding]; other site 656024005291 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 656024005292 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 656024005293 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 656024005294 Ligand Binding Site [chemical binding]; other site 656024005295 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 656024005296 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 656024005297 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024005298 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 656024005299 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 656024005300 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 656024005301 domain interfaces; other site 656024005302 active site 656024005303 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 656024005304 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 656024005305 Thioredoxin; Region: Thioredoxin_4; pfam13462 656024005306 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 656024005307 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 656024005308 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 656024005309 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 656024005310 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 656024005311 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 656024005312 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 656024005313 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 656024005314 GIY-YIG motif/motif A; other site 656024005315 active site 656024005316 catalytic site [active] 656024005317 putative DNA binding site [nucleotide binding]; other site 656024005318 metal binding site [ion binding]; metal-binding site 656024005319 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 656024005320 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 656024005321 Helix-hairpin-helix motif; Region: HHH; pfam00633 656024005322 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 656024005323 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 656024005324 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 656024005325 phosphate binding site [ion binding]; other site 656024005326 putative substrate binding pocket [chemical binding]; other site 656024005327 dimer interface [polypeptide binding]; other site 656024005328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 656024005329 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 656024005330 aconitate hydratase; Validated; Region: PRK09277 656024005331 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 656024005332 substrate binding site [chemical binding]; other site 656024005333 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 656024005334 ligand binding site [chemical binding]; other site 656024005335 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 656024005336 substrate binding site [chemical binding]; other site 656024005337 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 656024005338 NlpC/P60 family; Region: NLPC_P60; pfam00877 656024005339 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 656024005340 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 656024005341 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 656024005342 active site 656024005343 Substrate binding site; other site 656024005344 Mg++ binding site; other site 656024005345 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 656024005346 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 656024005347 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 656024005348 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 656024005349 lipoyl attachment site [posttranslational modification]; other site 656024005350 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 656024005351 Double zinc ribbon; Region: DZR; pfam12773 656024005352 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 656024005353 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 656024005354 phosphopeptide binding site; other site 656024005355 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 656024005356 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 656024005357 DNA binding residues [nucleotide binding] 656024005358 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 656024005359 Bifunctional nuclease; Region: DNase-RNase; pfam02577 656024005360 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 656024005361 DNA binding residues [nucleotide binding] 656024005362 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 656024005363 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 656024005364 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024005365 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 656024005366 Walker A/P-loop; other site 656024005367 ATP binding site [chemical binding]; other site 656024005368 Q-loop/lid; other site 656024005369 ABC transporter signature motif; other site 656024005370 Walker B; other site 656024005371 D-loop; other site 656024005372 H-loop/switch region; other site 656024005373 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 656024005374 ABC-2 type transporter; Region: ABC2_membrane; cl17235 656024005375 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 656024005376 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 656024005377 Glycosyltransferase family 20; Region: Glyco_transf_20; pfam00982 656024005378 active site 656024005379 homotetramer interface [polypeptide binding]; other site 656024005380 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 656024005381 catalytic core [active] 656024005382 Transcription factor WhiB; Region: Whib; pfam02467 656024005383 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 656024005384 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 656024005385 NlpC/P60 family; Region: NLPC_P60; pfam00877 656024005386 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 656024005387 active site residue [active] 656024005388 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 656024005389 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 656024005390 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 656024005391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024005392 Major Facilitator Superfamily; Region: MFS_1; pfam07690 656024005393 Major Facilitator Superfamily; Region: MFS_1; pfam07690 656024005394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024005395 putative substrate translocation pore; other site 656024005396 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 656024005397 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 656024005398 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 656024005399 active site residue [active] 656024005400 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 656024005401 active site residue [active] 656024005402 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 656024005403 dimerization interface [polypeptide binding]; other site 656024005404 putative DNA binding site [nucleotide binding]; other site 656024005405 putative Zn2+ binding site [ion binding]; other site 656024005406 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 656024005407 active site residue [active] 656024005408 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024005409 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024005410 DNA-binding interface [nucleotide binding]; DNA binding site 656024005411 putative transposase OrfB; Reviewed; Region: PHA02517 656024005412 HTH-like domain; Region: HTH_21; pfam13276 656024005413 Integrase core domain; Region: rve; pfam00665 656024005414 Integrase core domain; Region: rve_3; pfam13683 656024005415 OsmC-like protein; Region: OsmC; pfam02566 656024005416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 656024005417 S-adenosylmethionine binding site [chemical binding]; other site 656024005418 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 656024005419 Cytochrome P450; Region: p450; cl12078 656024005420 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 656024005421 EF-hand domain pair; Region: EF_hand_5; pfam13499 656024005422 Ca2+ binding site [ion binding]; other site 656024005423 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 656024005424 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 656024005425 ATP binding site [chemical binding]; other site 656024005426 putative Mg++ binding site [ion binding]; other site 656024005427 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 656024005428 nucleotide binding region [chemical binding]; other site 656024005429 ATP-binding site [chemical binding]; other site 656024005430 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 656024005431 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 656024005432 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 656024005433 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 656024005434 Uncharacterized conserved protein [Function unknown]; Region: COG1262 656024005435 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 656024005436 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 656024005437 Sulfatase; Region: Sulfatase; pfam00884 656024005438 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 656024005439 Sulfatase; Region: Sulfatase; pfam00884 656024005440 Predicted transcriptional regulator [Transcription]; Region: COG2378 656024005441 WYL domain; Region: WYL; pfam13280 656024005442 Predicted transcriptional regulator [Transcription]; Region: COG2378 656024005443 WYL domain; Region: WYL; pfam13280 656024005444 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 656024005445 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 656024005446 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 656024005447 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 656024005448 active site 656024005449 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 656024005450 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 656024005451 active site 656024005452 Pup-like protein; Region: Pup; pfam05639 656024005453 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 656024005454 proteasome ATPase; Region: pup_AAA; TIGR03689 656024005455 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 656024005456 Walker A motif; other site 656024005457 ATP binding site [chemical binding]; other site 656024005458 Walker B motif; other site 656024005459 arginine finger; other site 656024005460 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 656024005461 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 656024005462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 656024005463 S-adenosylmethionine binding site [chemical binding]; other site 656024005464 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 656024005465 active site 656024005466 putative substrate binding region [chemical binding]; other site 656024005467 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 656024005468 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 656024005469 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 656024005470 Walker A/P-loop; other site 656024005471 ATP binding site [chemical binding]; other site 656024005472 Q-loop/lid; other site 656024005473 ABC transporter signature motif; other site 656024005474 Walker B; other site 656024005475 D-loop; other site 656024005476 H-loop/switch region; other site 656024005477 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 656024005478 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 656024005479 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 656024005480 FtsX-like permease family; Region: FtsX; pfam02687 656024005481 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 656024005482 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 656024005483 sequence-specific DNA binding site [nucleotide binding]; other site 656024005484 salt bridge; other site 656024005485 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 656024005486 active site 656024005487 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024005488 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024005489 DNA-binding interface [nucleotide binding]; DNA binding site 656024005490 putative transposase OrfB; Reviewed; Region: PHA02517 656024005491 HTH-like domain; Region: HTH_21; pfam13276 656024005492 Integrase core domain; Region: rve; pfam00665 656024005493 Integrase core domain; Region: rve_3; pfam13683 656024005494 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 656024005495 DNA binding site [nucleotide binding] 656024005496 dimer interface [polypeptide binding]; other site 656024005497 active site 656024005498 Int/Topo IB signature motif; other site 656024005499 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 656024005500 FAD binding site [chemical binding]; other site 656024005501 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 656024005502 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 656024005503 putative DNA binding site [nucleotide binding]; other site 656024005504 putative Zn2+ binding site [ion binding]; other site 656024005505 AsnC family; Region: AsnC_trans_reg; pfam01037 656024005506 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 656024005507 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 656024005508 homodimer interface [polypeptide binding]; other site 656024005509 substrate-cofactor binding pocket; other site 656024005510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656024005511 catalytic residue [active] 656024005512 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 656024005513 nudix motif; other site 656024005514 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 656024005515 N-acetyl-D-glucosamine binding site [chemical binding]; other site 656024005516 catalytic residue [active] 656024005517 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 656024005518 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 656024005519 active site 656024005520 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 656024005521 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 656024005522 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 656024005523 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 656024005524 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 656024005525 active site 656024005526 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 656024005527 dimerization interface [polypeptide binding]; other site 656024005528 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 656024005529 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 656024005530 hypothetical protein; Provisional; Region: PRK07208 656024005531 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 656024005532 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 656024005533 AAA domain; Region: AAA_30; pfam13604 656024005534 Family description; Region: UvrD_C_2; pfam13538 656024005535 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 656024005536 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 656024005537 catalytic core [active] 656024005538 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 656024005539 conserved hypothetical protein; Region: TIGR03843 656024005540 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 656024005541 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 656024005542 active site 656024005543 HIGH motif; other site 656024005544 nucleotide binding site [chemical binding]; other site 656024005545 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 656024005546 active site 656024005547 KMSKS motif; other site 656024005548 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 656024005549 tRNA binding surface [nucleotide binding]; other site 656024005550 anticodon binding site; other site 656024005551 PAC2 family; Region: PAC2; pfam09754 656024005552 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 656024005553 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 656024005554 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 656024005555 substrate binding pocket [chemical binding]; other site 656024005556 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 656024005557 B12 binding site [chemical binding]; other site 656024005558 cobalt ligand [ion binding]; other site 656024005559 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 656024005560 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 656024005561 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 656024005562 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 656024005563 motif II; other site 656024005564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024005565 Major Facilitator Superfamily; Region: MFS_1; pfam07690 656024005566 putative substrate translocation pore; other site 656024005567 Predicted transcriptional regulators [Transcription]; Region: COG1733 656024005568 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 656024005569 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 656024005570 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 656024005571 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 656024005572 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 656024005573 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 656024005574 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 656024005575 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 656024005576 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 656024005577 dimerization interface [polypeptide binding]; other site 656024005578 putative DNA binding site [nucleotide binding]; other site 656024005579 putative Zn2+ binding site [ion binding]; other site 656024005580 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024005581 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024005582 DNA-binding interface [nucleotide binding]; DNA binding site 656024005583 putative transposase OrfB; Reviewed; Region: PHA02517 656024005584 HTH-like domain; Region: HTH_21; pfam13276 656024005585 Integrase core domain; Region: rve; pfam00665 656024005586 Integrase core domain; Region: rve_3; pfam13683 656024005587 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 656024005588 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024005589 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024005590 DNA-binding interface [nucleotide binding]; DNA binding site 656024005591 putative transposase OrfB; Reviewed; Region: PHA02517 656024005592 HTH-like domain; Region: HTH_21; pfam13276 656024005593 Integrase core domain; Region: rve; pfam00665 656024005594 Integrase core domain; Region: rve_3; pfam13683 656024005595 acyltransferase PapA5; Provisional; Region: PRK09294 656024005596 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 656024005597 Resolvase, N terminal domain; Region: Resolvase; pfam00239 656024005598 catalytic residues [active] 656024005599 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024005600 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024005601 DNA-binding interface [nucleotide binding]; DNA binding site 656024005602 putative transposase OrfB; Reviewed; Region: PHA02517 656024005603 HTH-like domain; Region: HTH_21; pfam13276 656024005604 Integrase core domain; Region: rve; pfam00665 656024005605 Integrase core domain; Region: rve_3; pfam13683 656024005606 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 656024005607 cobyric acid synthase; Provisional; Region: PRK00784 656024005608 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 656024005609 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 656024005610 catalytic triad [active] 656024005611 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 656024005612 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 656024005613 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 656024005614 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 656024005615 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 656024005616 DNA binding residues [nucleotide binding] 656024005617 dimerization interface [polypeptide binding]; other site 656024005618 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 656024005619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 656024005620 active site 656024005621 phosphorylation site [posttranslational modification] 656024005622 intermolecular recognition site; other site 656024005623 dimerization interface [polypeptide binding]; other site 656024005624 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 656024005625 DNA binding residues [nucleotide binding] 656024005626 Predicted transcriptional regulators [Transcription]; Region: COG1733 656024005627 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 656024005628 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 656024005629 Methyltransferase domain; Region: Methyltransf_11; pfam08241 656024005630 S-adenosylmethionine binding site [chemical binding]; other site 656024005631 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 656024005632 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 656024005633 Ligand binding site; other site 656024005634 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 656024005635 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 656024005636 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 656024005637 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 656024005638 Bacterial sugar transferase; Region: Bac_transf; cl00939 656024005639 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 656024005640 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 656024005641 active site 656024005642 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 656024005643 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 656024005644 inhibitor-cofactor binding pocket; inhibition site 656024005645 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656024005646 catalytic residue [active] 656024005647 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 656024005648 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 656024005649 NAD binding site [chemical binding]; other site 656024005650 substrate binding site [chemical binding]; other site 656024005651 active site 656024005652 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 656024005653 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 656024005654 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 656024005655 active site 656024005656 dimer interface [polypeptide binding]; other site 656024005657 motif 1; other site 656024005658 motif 2; other site 656024005659 motif 3; other site 656024005660 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 656024005661 anticodon binding site; other site 656024005662 O-Antigen ligase; Region: Wzy_C; pfam04932 656024005663 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 656024005664 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 656024005665 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 656024005666 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 656024005667 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656024005668 TIGR01777 family protein; Region: yfcH 656024005669 NAD(P) binding site [chemical binding]; other site 656024005670 active site 656024005671 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 656024005672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024005673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024005674 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 656024005675 apolar tunnel; other site 656024005676 heme binding site [chemical binding]; other site 656024005677 dimerization interface [polypeptide binding]; other site 656024005678 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 656024005679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 656024005680 active site 656024005681 phosphorylation site [posttranslational modification] 656024005682 intermolecular recognition site; other site 656024005683 dimerization interface [polypeptide binding]; other site 656024005684 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 656024005685 DNA binding residues [nucleotide binding] 656024005686 dimerization interface [polypeptide binding]; other site 656024005687 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 656024005688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 656024005689 active site 656024005690 phosphorylation site [posttranslational modification] 656024005691 intermolecular recognition site; other site 656024005692 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 656024005693 DNA binding residues [nucleotide binding] 656024005694 dimerization interface [polypeptide binding]; other site 656024005695 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673 656024005696 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 656024005697 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 656024005698 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 656024005699 carboxyltransferase (CT) interaction site; other site 656024005700 biotinylation site [posttranslational modification]; other site 656024005701 N-terminal aromatase/cyclase domain of the multifunctional protein tetracenomycin (TcmN) and related domains; Region: TcmN_ARO-CYC_like; cd08860 656024005702 putative hydrophobic ligand binding site [chemical binding]; other site 656024005703 active site 656024005704 catalytic residues_2 [active] 656024005705 catalytic residues_1 [active] 656024005706 Cupin domain; Region: Cupin_2; pfam07883 656024005707 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 656024005708 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 656024005709 dimer interface [polypeptide binding]; other site 656024005710 active site 656024005711 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 656024005712 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 656024005713 active site 656024005714 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 656024005715 putative Zn2+ binding site [ion binding]; other site 656024005716 putative DNA binding site [nucleotide binding]; other site 656024005717 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 656024005718 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 656024005719 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 656024005720 metal ion-dependent adhesion site (MIDAS); other site 656024005721 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 656024005722 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 656024005723 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 656024005724 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 656024005725 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 656024005726 catalytic triad [active] 656024005727 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 656024005728 homodimer interface [polypeptide binding]; other site 656024005729 active site 656024005730 SAM binding site [chemical binding]; other site 656024005731 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 656024005732 active site 656024005733 SAM binding site [chemical binding]; other site 656024005734 homodimer interface [polypeptide binding]; other site 656024005735 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 656024005736 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 656024005737 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 656024005738 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 656024005739 active site 656024005740 homodimer interface [polypeptide binding]; other site 656024005741 SAM binding site [chemical binding]; other site 656024005742 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 656024005743 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 656024005744 putative active site [active] 656024005745 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 656024005746 putative active site [active] 656024005747 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 656024005748 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 656024005749 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 656024005750 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 656024005751 putative active site [active] 656024005752 putative transposase OrfB; Reviewed; Region: PHA02517 656024005753 HTH-like domain; Region: HTH_21; pfam13276 656024005754 Integrase core domain; Region: rve; pfam00665 656024005755 Integrase core domain; Region: rve_3; pfam13683 656024005756 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024005757 Transposase; Region: HTH_Tnp_1; pfam01527 656024005758 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 656024005759 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 656024005760 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 656024005761 putative acyl-acceptor binding pocket; other site 656024005762 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 656024005763 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 656024005764 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 656024005765 NAD(P) binding site [chemical binding]; other site 656024005766 fatty acyl-CoA reductase; Region: PLN02996 656024005767 Male sterility protein; Region: NAD_binding_4; pfam07993 656024005768 NAD(P) binding site [chemical binding]; other site 656024005769 active site 656024005770 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656024005771 active site 656024005772 C-terminal domain of fatty acyl CoA reductases; Region: FAR_C; cd09071 656024005773 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 656024005774 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 656024005775 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 656024005776 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 656024005777 active site 656024005778 metal binding site 1 [ion binding]; metal-binding site 656024005779 putative 5' ssDNA interaction site; other site 656024005780 metal binding site 3; metal-binding site 656024005781 metal binding site 2 [ion binding]; metal-binding site 656024005782 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 656024005783 putative DNA binding site [nucleotide binding]; other site 656024005784 putative metal binding site [ion binding]; other site 656024005785 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 656024005786 dimerization interface [polypeptide binding]; other site 656024005787 putative DNA binding site [nucleotide binding]; other site 656024005788 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 656024005789 putative Zn2+ binding site [ion binding]; other site 656024005790 AsnC family; Region: AsnC_trans_reg; pfam01037 656024005791 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 656024005792 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 656024005793 active site 656024005794 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 656024005795 Winged helix-turn helix; Region: HTH_29; pfam13551 656024005796 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024005797 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 656024005798 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 656024005799 putative active site [active] 656024005800 catalytic triad [active] 656024005801 putative dimer interface [polypeptide binding]; other site 656024005802 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 656024005803 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 656024005804 Ligand binding site; other site 656024005805 Putative Catalytic site; other site 656024005806 DXD motif; other site 656024005807 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 656024005808 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 656024005809 methionine sulfoxide reductase B; Provisional; Region: PRK00222 656024005810 SelR domain; Region: SelR; pfam01641 656024005811 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 656024005812 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 656024005813 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 656024005814 active site 656024005815 CoA binding site [chemical binding]; other site 656024005816 AMP binding site [chemical binding]; other site 656024005817 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 656024005818 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 656024005819 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 656024005820 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 656024005821 NAD(P) binding pocket [chemical binding]; other site 656024005822 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 656024005823 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656024005824 metal binding site [ion binding]; metal-binding site 656024005825 active site 656024005826 I-site; other site 656024005827 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 656024005828 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 656024005829 inhibitor-cofactor binding pocket; inhibition site 656024005830 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656024005831 catalytic residue [active] 656024005832 Predicted membrane protein [Function unknown]; Region: COG2261 656024005833 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 656024005834 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 656024005835 pyruvate carboxylase; Reviewed; Region: PRK12999 656024005836 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 656024005837 ATP-grasp domain; Region: ATP-grasp_4; cl17255 656024005838 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 656024005839 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 656024005840 active site 656024005841 catalytic residues [active] 656024005842 metal binding site [ion binding]; metal-binding site 656024005843 homodimer binding site [polypeptide binding]; other site 656024005844 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 656024005845 carboxyltransferase (CT) interaction site; other site 656024005846 biotinylation site [posttranslational modification]; other site 656024005847 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 656024005848 DNA binding site [nucleotide binding] 656024005849 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 656024005850 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 656024005851 Ligand Binding Site [chemical binding]; other site 656024005852 Molecular Tunnel; other site 656024005853 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 656024005854 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 656024005855 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 656024005856 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024005857 Walker A/P-loop; other site 656024005858 ATP binding site [chemical binding]; other site 656024005859 Q-loop/lid; other site 656024005860 ABC transporter signature motif; other site 656024005861 Walker B; other site 656024005862 D-loop; other site 656024005863 H-loop/switch region; other site 656024005864 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 656024005865 Homeodomain-like domain; Region: HTH_23; pfam13384 656024005866 Winged helix-turn helix; Region: HTH_29; pfam13551 656024005867 Homeodomain-like domain; Region: HTH_32; pfam13565 656024005868 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024005869 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 656024005870 hypothetical protein; Provisional; Region: PRK07906 656024005871 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 656024005872 putative metal binding site [ion binding]; other site 656024005873 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 656024005874 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 656024005875 DNA binding residues [nucleotide binding] 656024005876 dimer interface [polypeptide binding]; other site 656024005877 [2Fe-2S] cluster binding site [ion binding]; other site 656024005878 Winged helix-turn helix; Region: HTH_29; pfam13551 656024005879 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024005880 Homeodomain-like domain; Region: HTH_23; pfam13384 656024005881 Winged helix-turn helix; Region: HTH_29; pfam13551 656024005882 Homeodomain-like domain; Region: HTH_32; pfam13565 656024005883 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024005884 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 656024005885 Homeodomain-like domain; Region: HTH_23; pfam13384 656024005886 Winged helix-turn helix; Region: HTH_29; pfam13551 656024005887 Homeodomain-like domain; Region: HTH_32; pfam13565 656024005888 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024005889 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 656024005890 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024005891 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 656024005892 putative substrate translocation pore; other site 656024005893 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 656024005894 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024005895 Walker A/P-loop; other site 656024005896 ATP binding site [chemical binding]; other site 656024005897 Q-loop/lid; other site 656024005898 ABC transporter signature motif; other site 656024005899 Walker B; other site 656024005900 D-loop; other site 656024005901 H-loop/switch region; other site 656024005902 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 656024005903 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 656024005904 active site 656024005905 phosphorylation site [posttranslational modification] 656024005906 intermolecular recognition site; other site 656024005907 dimerization interface [polypeptide binding]; other site 656024005908 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 656024005909 DNA binding residues [nucleotide binding] 656024005910 dimerization interface [polypeptide binding]; other site 656024005911 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 656024005912 Histidine kinase; Region: HisKA_3; pfam07730 656024005913 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 656024005914 putative homodimer interface [polypeptide binding]; other site 656024005915 putative homotetramer interface [polypeptide binding]; other site 656024005916 putative allosteric switch controlling residues; other site 656024005917 putative metal binding site [ion binding]; other site 656024005918 putative homodimer-homodimer interface [polypeptide binding]; other site 656024005919 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 656024005920 metal-binding site [ion binding] 656024005921 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 656024005922 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 656024005923 metal-binding site [ion binding] 656024005924 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 656024005925 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 656024005926 Homeodomain-like domain; Region: HTH_23; pfam13384 656024005927 Winged helix-turn helix; Region: HTH_29; pfam13551 656024005928 Homeodomain-like domain; Region: HTH_32; pfam13565 656024005929 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024005930 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 656024005931 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 656024005932 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 656024005933 Radical SAM superfamily; Region: Radical_SAM; pfam04055 656024005934 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 656024005935 FeS/SAM binding site; other site 656024005936 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 656024005937 Dienelactone hydrolase family; Region: DLH; pfam01738 656024005938 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 656024005939 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 656024005940 inhibitor-cofactor binding pocket; inhibition site 656024005941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656024005942 catalytic residue [active] 656024005943 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 656024005944 AMP-binding enzyme; Region: AMP-binding; pfam00501 656024005945 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 656024005946 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 656024005947 Protein of unknown function DUF72; Region: DUF72; pfam01904 656024005948 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 656024005949 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 656024005950 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 656024005951 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 656024005952 protein binding site [polypeptide binding]; other site 656024005953 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 656024005954 N-acetyl-D-glucosamine binding site [chemical binding]; other site 656024005955 catalytic residue [active] 656024005956 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 656024005957 NlpC/P60 family; Region: NLPC_P60; pfam00877 656024005958 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 656024005959 DNA-binding site [nucleotide binding]; DNA binding site 656024005960 RNA-binding motif; other site 656024005961 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 656024005962 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 656024005963 TPP-binding site [chemical binding]; other site 656024005964 dimer interface [polypeptide binding]; other site 656024005965 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 656024005966 PYR/PP interface [polypeptide binding]; other site 656024005967 dimer interface [polypeptide binding]; other site 656024005968 TPP binding site [chemical binding]; other site 656024005969 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 656024005970 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 656024005971 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 656024005972 Iron permease FTR1 family; Region: FTR1; pfam03239 656024005973 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 656024005974 Imelysin; Region: Peptidase_M75; cl09159 656024005975 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 656024005976 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024005977 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024005978 DNA-binding interface [nucleotide binding]; DNA binding site 656024005979 putative transposase OrfB; Reviewed; Region: PHA02517 656024005980 HTH-like domain; Region: HTH_21; pfam13276 656024005981 Integrase core domain; Region: rve; pfam00665 656024005982 Integrase core domain; Region: rve_3; pfam13683 656024005983 Winged helix-turn helix; Region: HTH_29; pfam13551 656024005984 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024005985 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024005986 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024005987 DNA-binding interface [nucleotide binding]; DNA binding site 656024005988 putative transposase OrfB; Reviewed; Region: PHA02517 656024005989 HTH-like domain; Region: HTH_21; pfam13276 656024005990 Integrase core domain; Region: rve; pfam00665 656024005991 Integrase core domain; Region: rve_3; pfam13683 656024005992 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 656024005993 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 656024005994 putative active site [active] 656024005995 putative NTP binding site [chemical binding]; other site 656024005996 putative nucleic acid binding site [nucleotide binding]; other site 656024005997 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 656024005998 FOG: WD40 repeat [General function prediction only]; Region: COG2319 656024005999 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 656024006000 structural tetrad; other site 656024006001 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656024006002 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024006003 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 656024006004 DNA binding site [nucleotide binding] 656024006005 Bacterial transcriptional activator domain; Region: BTAD; smart01043 656024006006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024006007 Major Facilitator Superfamily; Region: MFS_1; pfam07690 656024006008 putative substrate translocation pore; other site 656024006009 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656024006010 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024006011 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 656024006012 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 656024006013 active site 656024006014 non-prolyl cis peptide bond; other site 656024006015 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 656024006016 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 656024006017 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 656024006018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 656024006019 ABC-ATPase subunit interface; other site 656024006020 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 656024006021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 656024006022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 656024006023 dimer interface [polypeptide binding]; other site 656024006024 conserved gate region; other site 656024006025 putative PBP binding loops; other site 656024006026 ABC-ATPase subunit interface; other site 656024006027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 656024006028 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 656024006029 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 656024006030 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 656024006031 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 656024006032 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 656024006033 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 656024006034 HupF/HypC family; Region: HupF_HypC; pfam01455 656024006035 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 656024006036 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 656024006037 dimerization interface [polypeptide binding]; other site 656024006038 ATP binding site [chemical binding]; other site 656024006039 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 656024006040 dimer interface [polypeptide binding]; other site 656024006041 active site 656024006042 HupF/HypC family; Region: HupF_HypC; cl00394 656024006043 HupF/HypC family; Region: HupF_HypC; pfam01455 656024006044 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 656024006045 Acylphosphatase; Region: Acylphosphatase; pfam00708 656024006046 HypF finger; Region: zf-HYPF; pfam07503 656024006047 HypF finger; Region: zf-HYPF; pfam07503 656024006048 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 656024006049 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 656024006050 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 656024006051 nickel binding site [ion binding]; other site 656024006052 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 656024006053 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 656024006054 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 656024006055 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 656024006056 Homeodomain-like domain; Region: HTH_23; pfam13384 656024006057 Winged helix-turn helix; Region: HTH_29; pfam13551 656024006058 Homeodomain-like domain; Region: HTH_32; pfam13565 656024006059 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024006060 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 656024006061 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024006062 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 656024006063 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 656024006064 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 656024006065 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 656024006066 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 656024006067 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 656024006068 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 656024006069 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 656024006070 oligomer interface [polypeptide binding]; other site 656024006071 active site residues [active] 656024006072 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 656024006073 homodimer interface [polypeptide binding]; other site 656024006074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656024006075 catalytic residue [active] 656024006076 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 656024006077 substrate-cofactor binding pocket; other site 656024006078 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 656024006079 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 656024006080 non-specific DNA binding site [nucleotide binding]; other site 656024006081 salt bridge; other site 656024006082 sequence-specific DNA binding site [nucleotide binding]; other site 656024006083 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 656024006084 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 656024006085 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 656024006086 Ligand Binding Site [chemical binding]; other site 656024006087 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 656024006088 Ligand Binding Site [chemical binding]; other site 656024006089 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 656024006090 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 656024006091 putative dimer interface [polypeptide binding]; other site 656024006092 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 656024006093 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 656024006094 putative active site [active] 656024006095 oxyanion strand; other site 656024006096 catalytic triad [active] 656024006097 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 656024006098 putative active site pocket [active] 656024006099 4-fold oligomerization interface [polypeptide binding]; other site 656024006100 metal binding residues [ion binding]; metal-binding site 656024006101 3-fold/trimer interface [polypeptide binding]; other site 656024006102 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 656024006103 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 656024006104 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656024006105 homodimer interface [polypeptide binding]; other site 656024006106 catalytic residue [active] 656024006107 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 656024006108 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 656024006109 NAD binding site [chemical binding]; other site 656024006110 dimerization interface [polypeptide binding]; other site 656024006111 product binding site; other site 656024006112 substrate binding site [chemical binding]; other site 656024006113 zinc binding site [ion binding]; other site 656024006114 catalytic residues [active] 656024006115 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 656024006116 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 656024006117 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 656024006118 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 656024006119 Protein of unknown function N-terminus (DUF3323); Region: DUF3323; pfam11796 656024006120 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 656024006121 TIGR02680 family protein; Region: TIGR02680 656024006122 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 656024006123 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 656024006124 TIGR02677 family protein; Region: TIGR02677 656024006125 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 656024006126 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 656024006127 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024006128 WHG domain; Region: WHG; pfam13305 656024006129 SnoaL-like domain; Region: SnoaL_2; pfam12680 656024006130 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 656024006131 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 656024006132 dimer interface [polypeptide binding]; other site 656024006133 catalytic triad [active] 656024006134 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 656024006135 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 656024006136 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 656024006137 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 656024006138 dimer interface [polypeptide binding]; other site 656024006139 TPP-binding site [chemical binding]; other site 656024006140 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 656024006141 Pirin; Region: Pirin; pfam02678 656024006142 Pirin-related protein [General function prediction only]; Region: COG1741 656024006143 CoA binding domain; Region: CoA_binding; cl17356 656024006144 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 656024006145 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 656024006146 HypX protein, N-terminal hydrolase domain; Region: FMT_core_HypX_N; cd08650 656024006147 putative active site [active] 656024006148 putative substrate binding site [chemical binding]; other site 656024006149 putative cosubstrate binding site; other site 656024006150 catalytic site [active] 656024006151 C-terminal subdomain of the Formyltransferase-like domain found in HypX-like proteins; Region: FMT_C_HypX; cd08701 656024006152 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 656024006153 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 656024006154 substrate binding site [chemical binding]; other site 656024006155 oxyanion hole (OAH) forming residues; other site 656024006156 trimer interface [polypeptide binding]; other site 656024006157 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 656024006158 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 656024006159 putative metal binding site [ion binding]; other site 656024006160 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 656024006161 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 656024006162 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 656024006163 Soluble P-type ATPase [General function prediction only]; Region: COG4087 656024006164 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 656024006165 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 656024006166 active site 656024006167 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 656024006168 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 656024006169 ATP binding site [chemical binding]; other site 656024006170 putative Mg++ binding site [ion binding]; other site 656024006171 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 656024006172 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 656024006173 Zn2+ binding site [ion binding]; other site 656024006174 Mg2+ binding site [ion binding]; other site 656024006175 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 656024006176 synthetase active site [active] 656024006177 NTP binding site [chemical binding]; other site 656024006178 metal binding site [ion binding]; metal-binding site 656024006179 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 656024006180 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 656024006181 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 656024006182 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 656024006183 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 656024006184 Zn2+ binding site [ion binding]; other site 656024006185 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 656024006186 synthetase active site [active] 656024006187 NTP binding site [chemical binding]; other site 656024006188 metal binding site [ion binding]; metal-binding site 656024006189 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 656024006190 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 656024006191 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 656024006192 active site 656024006193 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 656024006194 Protein export membrane protein; Region: SecD_SecF; pfam02355 656024006195 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 656024006196 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 656024006197 Preprotein translocase subunit; Region: YajC; pfam02699 656024006198 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 656024006199 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 656024006200 Walker A motif; other site 656024006201 ATP binding site [chemical binding]; other site 656024006202 Walker B motif; other site 656024006203 arginine finger; other site 656024006204 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 656024006205 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 656024006206 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 656024006207 active site 656024006208 putative DNA-binding cleft [nucleotide binding]; other site 656024006209 dimer interface [polypeptide binding]; other site 656024006210 hypothetical protein; Validated; Region: PRK00110 656024006211 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 656024006212 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13143 656024006213 predicted active site [active] 656024006214 catalytic triad [active] 656024006215 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 656024006216 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 656024006217 active site 656024006218 multimer interface [polypeptide binding]; other site 656024006219 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 656024006220 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 656024006221 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 656024006222 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 656024006223 putative acyl-acceptor binding pocket; other site 656024006224 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 656024006225 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 656024006226 elongation factor G; Reviewed; Region: PRK12740 656024006227 G1 box; other site 656024006228 GTP/Mg2+ binding site [chemical binding]; other site 656024006229 G2 box; other site 656024006230 Switch I region; other site 656024006231 G3 box; other site 656024006232 Switch II region; other site 656024006233 G4 box; other site 656024006234 G5 box; other site 656024006235 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 656024006236 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 656024006237 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 656024006238 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 656024006239 nucleotide binding site/active site [active] 656024006240 HIT family signature motif; other site 656024006241 catalytic residue [active] 656024006242 Cytochrome P450; Region: p450; cl12078 656024006243 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 656024006244 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 656024006245 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 656024006246 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 656024006247 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656024006248 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024006249 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 656024006250 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 656024006251 active site 656024006252 metal binding site [ion binding]; metal-binding site 656024006253 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 656024006254 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 656024006255 Isochorismatase family; Region: Isochorismatase; pfam00857 656024006256 catalytic triad [active] 656024006257 conserved cis-peptide bond; other site 656024006258 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 656024006259 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 656024006260 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 656024006261 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 656024006262 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 656024006263 active site 656024006264 catalytic site [active] 656024006265 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 656024006266 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 656024006267 active site 656024006268 catalytic site [active] 656024006269 potential frameshift: common BLAST hit: gi|159037594|ref|YP_001536847.1| CRISPR-associated helicase Cas3 656024006270 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 656024006271 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 656024006272 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 656024006273 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 656024006274 Walker A/P-loop; other site 656024006275 ATP binding site [chemical binding]; other site 656024006276 Q-loop/lid; other site 656024006277 ABC transporter signature motif; other site 656024006278 Walker B; other site 656024006279 H-loop/switch region; other site 656024006280 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 656024006281 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 656024006282 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024006283 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024006284 DNA-binding interface [nucleotide binding]; DNA binding site 656024006285 putative transposase OrfB; Reviewed; Region: PHA02517 656024006286 HTH-like domain; Region: HTH_21; pfam13276 656024006287 Integrase core domain; Region: rve; pfam00665 656024006288 Integrase core domain; Region: rve_3; pfam13683 656024006289 Htaa; Region: HtaA; pfam04213 656024006290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024006291 Major Facilitator Superfamily; Region: MFS_1; pfam07690 656024006292 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 656024006293 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 656024006294 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 656024006295 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 656024006296 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 656024006297 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 656024006298 putative acyl-acceptor binding pocket; other site 656024006299 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 656024006300 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 656024006301 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 656024006302 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 656024006303 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 656024006304 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 656024006305 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 656024006306 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 656024006307 Serine hydrolase; Region: Ser_hydrolase; cl17834 656024006308 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 656024006309 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 656024006310 DNA-binding site [nucleotide binding]; DNA binding site 656024006311 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 656024006312 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 656024006313 malonyl-CoA binding site [chemical binding]; other site 656024006314 dimer interface [polypeptide binding]; other site 656024006315 active site 656024006316 product binding site; other site 656024006317 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 656024006318 Cytochrome P450; Region: p450; cl12078 656024006319 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 656024006320 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 656024006321 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 656024006322 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 656024006323 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 656024006324 Phosphopantetheine attachment site; Region: PP-binding; cl09936 656024006325 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 656024006326 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 656024006327 FMN binding site [chemical binding]; other site 656024006328 substrate binding site [chemical binding]; other site 656024006329 putative catalytic residue [active] 656024006330 hypothetical protein; Validated; Region: PRK07080 656024006331 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 656024006332 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 656024006333 active site 656024006334 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 656024006335 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 656024006336 inhibitor-cofactor binding pocket; inhibition site 656024006337 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656024006338 catalytic residue [active] 656024006339 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cd00421 656024006340 active site 656024006341 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 656024006342 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 656024006343 NAD(P) binding site [chemical binding]; other site 656024006344 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 656024006345 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 656024006346 Phosphotransferase enzyme family; Region: APH; pfam01636 656024006347 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 656024006348 putative active site [active] 656024006349 putative substrate binding site [chemical binding]; other site 656024006350 ATP binding site [chemical binding]; other site 656024006351 short chain dehydrogenase; Provisional; Region: PRK06172 656024006352 classical (c) SDRs; Region: SDR_c; cd05233 656024006353 NAD(P) binding site [chemical binding]; other site 656024006354 active site 656024006355 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 656024006356 Amidinotransferase; Region: Amidinotransf; cl12043 656024006357 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 656024006358 Walker A motif; other site 656024006359 ATP binding site [chemical binding]; other site 656024006360 PAS fold; Region: PAS_4; pfam08448 656024006361 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656024006362 metal binding site [ion binding]; metal-binding site 656024006363 active site 656024006364 I-site; other site 656024006365 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 656024006366 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 656024006367 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 656024006368 DNA binding residues [nucleotide binding] 656024006369 dimerization interface [polypeptide binding]; other site 656024006370 AAA ATPase domain; Region: AAA_16; pfam13191 656024006371 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 656024006372 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 656024006373 Walker A/P-loop; other site 656024006374 ATP binding site [chemical binding]; other site 656024006375 Q-loop/lid; other site 656024006376 ABC transporter signature motif; other site 656024006377 Walker B; other site 656024006378 D-loop; other site 656024006379 H-loop/switch region; other site 656024006380 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 656024006381 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 656024006382 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 656024006383 Walker A/P-loop; other site 656024006384 ATP binding site [chemical binding]; other site 656024006385 Q-loop/lid; other site 656024006386 ABC transporter signature motif; other site 656024006387 Walker B; other site 656024006388 D-loop; other site 656024006389 H-loop/switch region; other site 656024006390 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 656024006391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 656024006392 ABC-ATPase subunit interface; other site 656024006393 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 656024006394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 656024006395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024006396 putative substrate translocation pore; other site 656024006397 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656024006398 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024006399 Thioesterase domain; Region: Thioesterase; pfam00975 656024006400 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 656024006401 nucleophilic elbow; other site 656024006402 catalytic triad; other site 656024006403 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 656024006404 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 656024006405 active site 656024006406 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 656024006407 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 656024006408 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 656024006409 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 656024006410 classical (c) SDRs; Region: SDR_c; cd05233 656024006411 NAD(P) binding site [chemical binding]; other site 656024006412 active site 656024006413 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 656024006414 SnoaL-like domain; Region: SnoaL_4; pfam13577 656024006415 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 656024006416 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 656024006417 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656024006418 WHG domain; Region: WHG; pfam13305 656024006419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024006420 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 656024006421 putative substrate translocation pore; other site 656024006422 malate synthase A; Region: malate_syn_A; TIGR01344 656024006423 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 656024006424 active site 656024006425 FOG: WD40 repeat [General function prediction only]; Region: COG2319 656024006426 WD domain, G-beta repeat; Region: WD40; pfam00400 656024006427 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024006428 Transposase; Region: HTH_Tnp_1; pfam01527 656024006429 putative transposase OrfB; Reviewed; Region: PHA02517 656024006430 HTH-like domain; Region: HTH_21; pfam13276 656024006431 Integrase core domain; Region: rve; pfam00665 656024006432 Integrase core domain; Region: rve_3; pfam13683 656024006433 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 656024006434 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 656024006435 putative active site [active] 656024006436 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 656024006437 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 656024006438 Walker A motif; other site 656024006439 ATP binding site [chemical binding]; other site 656024006440 Walker B motif; other site 656024006441 arginine finger; other site 656024006442 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 656024006443 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 656024006444 Walker A motif; other site 656024006445 ATP binding site [chemical binding]; other site 656024006446 Walker B motif; other site 656024006447 arginine finger; other site 656024006448 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 656024006449 Prostaglandin dehydrogenases; Region: PGDH; cd05288 656024006450 NAD(P) binding site [chemical binding]; other site 656024006451 substrate binding site [chemical binding]; other site 656024006452 dimer interface [polypeptide binding]; other site 656024006453 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 656024006454 ferredoxin-like protein FixX; Provisional; Region: PRK15449 656024006455 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 656024006456 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 656024006457 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 656024006458 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 656024006459 putative active site [active] 656024006460 putative FMN binding site [chemical binding]; other site 656024006461 putative substrate binding site [chemical binding]; other site 656024006462 putative catalytic residue [active] 656024006463 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 656024006464 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 656024006465 phosphate binding site [ion binding]; other site 656024006466 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 656024006467 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 656024006468 FeS/SAM binding site; other site 656024006469 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 656024006470 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 656024006471 mycofactocin precursor; Region: mycofactocin; TIGR03969 656024006472 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656024006473 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024006474 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 656024006475 CoA-transferase family III; Region: CoA_transf_3; pfam02515 656024006476 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 656024006477 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 656024006478 putative ligand binding site [chemical binding]; other site 656024006479 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 656024006480 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 656024006481 putative ligand binding site [chemical binding]; other site 656024006482 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 656024006483 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 656024006484 putative ligand binding site [chemical binding]; other site 656024006485 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 656024006486 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 656024006487 Walker A/P-loop; other site 656024006488 ATP binding site [chemical binding]; other site 656024006489 Q-loop/lid; other site 656024006490 ABC transporter signature motif; other site 656024006491 Walker B; other site 656024006492 D-loop; other site 656024006493 H-loop/switch region; other site 656024006494 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 656024006495 TM-ABC transporter signature motif; other site 656024006496 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 656024006497 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 656024006498 TM-ABC transporter signature motif; other site 656024006499 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 656024006500 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 656024006501 Walker A/P-loop; other site 656024006502 ATP binding site [chemical binding]; other site 656024006503 Q-loop/lid; other site 656024006504 ABC transporter signature motif; other site 656024006505 Walker B; other site 656024006506 D-loop; other site 656024006507 H-loop/switch region; other site 656024006508 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024006509 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024006510 DNA-binding interface [nucleotide binding]; DNA binding site 656024006511 putative transposase OrfB; Reviewed; Region: PHA02517 656024006512 HTH-like domain; Region: HTH_21; pfam13276 656024006513 Integrase core domain; Region: rve; pfam00665 656024006514 Integrase core domain; Region: rve_3; pfam13683 656024006515 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 656024006516 mce related protein; Region: MCE; pfam02470 656024006517 mce related protein; Region: MCE; pfam02470 656024006518 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 656024006519 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 656024006520 mce related protein; Region: MCE; pfam02470 656024006521 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 656024006522 Winged helix-turn helix; Region: HTH_29; pfam13551 656024006523 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024006524 Homeodomain-like domain; Region: HTH_23; pfam13384 656024006525 Winged helix-turn helix; Region: HTH_29; pfam13551 656024006526 Homeodomain-like domain; Region: HTH_32; pfam13565 656024006527 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024006528 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 656024006529 Homeodomain-like domain; Region: HTH_23; pfam13384 656024006530 Winged helix-turn helix; Region: HTH_29; pfam13551 656024006531 Homeodomain-like domain; Region: HTH_32; pfam13565 656024006532 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024006533 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 656024006534 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 656024006535 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 656024006536 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 656024006537 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 656024006538 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 656024006539 Walker A motif; other site 656024006540 ATP binding site [chemical binding]; other site 656024006541 Walker B motif; other site 656024006542 arginine finger; other site 656024006543 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 656024006544 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 656024006545 DNA binding residues [nucleotide binding] 656024006546 dimerization interface [polypeptide binding]; other site 656024006547 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 656024006548 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 656024006549 DNA binding residues [nucleotide binding] 656024006550 dimerization interface [polypeptide binding]; other site 656024006551 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 656024006552 active site 656024006553 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 656024006554 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 656024006555 tetramer interface [polypeptide binding]; other site 656024006556 active site 656024006557 Mg2+/Mn2+ binding site [ion binding]; other site 656024006558 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 656024006559 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 656024006560 Subunit I/III interface [polypeptide binding]; other site 656024006561 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 656024006562 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 656024006563 classical (c) SDRs; Region: SDR_c; cd05233 656024006564 NAD(P) binding site [chemical binding]; other site 656024006565 active site 656024006566 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 656024006567 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 656024006568 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 656024006569 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 656024006570 acyl-activating enzyme (AAE) consensus motif; other site 656024006571 AMP binding site [chemical binding]; other site 656024006572 active site 656024006573 CoA binding site [chemical binding]; other site 656024006574 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 656024006575 Cytochrome P450; Region: p450; cl12078 656024006576 DUF35 OB-fold domain; Region: DUF35; pfam01796 656024006577 lipid-transfer protein; Provisional; Region: PRK07855 656024006578 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 656024006579 active site 656024006580 Phosphotransferase enzyme family; Region: APH; pfam01636 656024006581 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 656024006582 putative active site [active] 656024006583 putative substrate binding site [chemical binding]; other site 656024006584 ATP binding site [chemical binding]; other site 656024006585 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 656024006586 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 656024006587 NAD(P) binding site [chemical binding]; other site 656024006588 catalytic residues [active] 656024006589 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 656024006590 Strictosidine synthase; Region: Str_synth; pfam03088 656024006591 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 656024006592 Catalytic domain of Protein Kinases; Region: PKc; cd00180 656024006593 active site 656024006594 ATP binding site [chemical binding]; other site 656024006595 substrate binding site [chemical binding]; other site 656024006596 activation loop (A-loop); other site 656024006597 AAA ATPase domain; Region: AAA_16; pfam13191 656024006598 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 656024006599 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 656024006600 Histidine kinase; Region: HisKA_3; pfam07730 656024006601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656024006602 ATP binding site [chemical binding]; other site 656024006603 Mg2+ binding site [ion binding]; other site 656024006604 G-X-G motif; other site 656024006605 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 656024006606 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 656024006607 active site 656024006608 phosphorylation site [posttranslational modification] 656024006609 intermolecular recognition site; other site 656024006610 dimerization interface [polypeptide binding]; other site 656024006611 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 656024006612 dimerization interface [polypeptide binding]; other site 656024006613 DNA binding residues [nucleotide binding] 656024006614 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 656024006615 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 656024006616 Fic family protein [Function unknown]; Region: COG3177 656024006617 Fic/DOC family; Region: Fic; pfam02661 656024006618 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 656024006619 nudix motif; other site 656024006620 tellurite resistance protein terB; Region: terB; cd07176 656024006621 putative metal binding site [ion binding]; other site 656024006622 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 656024006623 nudix motif; other site 656024006624 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 656024006625 Coenzyme A binding pocket [chemical binding]; other site 656024006626 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 656024006627 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 656024006628 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 656024006629 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 656024006630 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 656024006631 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 656024006632 RNA binding site [nucleotide binding]; other site 656024006633 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 656024006634 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 656024006635 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 656024006636 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 656024006637 putative active site [active] 656024006638 putative NTP binding site [chemical binding]; other site 656024006639 putative nucleic acid binding site [nucleotide binding]; other site 656024006640 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 656024006641 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 656024006642 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024006643 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024006644 DNA-binding interface [nucleotide binding]; DNA binding site 656024006645 putative transposase OrfB; Reviewed; Region: PHA02517 656024006646 HTH-like domain; Region: HTH_21; pfam13276 656024006647 Integrase core domain; Region: rve; pfam00665 656024006648 Integrase core domain; Region: rve_3; pfam13683 656024006649 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 656024006650 S-adenosylmethionine binding site [chemical binding]; other site 656024006651 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 656024006652 Mechanosensitive ion channel; Region: MS_channel; pfam00924 656024006653 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 656024006654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 656024006655 S-adenosylmethionine binding site [chemical binding]; other site 656024006656 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 656024006657 active site 656024006658 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024006659 Transposase; Region: HTH_Tnp_1; pfam01527 656024006660 putative transposase OrfB; Reviewed; Region: PHA02517 656024006661 HTH-like domain; Region: HTH_21; pfam13276 656024006662 Integrase core domain; Region: rve; pfam00665 656024006663 Integrase core domain; Region: rve_3; pfam13683 656024006664 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 656024006665 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 656024006666 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 656024006667 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 656024006668 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 656024006669 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024006670 Walker A/P-loop; other site 656024006671 ATP binding site [chemical binding]; other site 656024006672 Q-loop/lid; other site 656024006673 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024006674 ABC transporter signature motif; other site 656024006675 Walker B; other site 656024006676 D-loop; other site 656024006677 H-loop/switch region; other site 656024006678 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024006679 Walker A/P-loop; other site 656024006680 ATP binding site [chemical binding]; other site 656024006681 Q-loop/lid; other site 656024006682 ABC transporter signature motif; other site 656024006683 Walker B; other site 656024006684 D-loop; other site 656024006685 H-loop/switch region; other site 656024006686 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 656024006687 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 656024006688 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 656024006689 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 656024006690 active site 656024006691 non-prolyl cis peptide bond; other site 656024006692 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_9; cd08496 656024006693 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 656024006694 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 656024006695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 656024006696 dimer interface [polypeptide binding]; other site 656024006697 conserved gate region; other site 656024006698 putative PBP binding loops; other site 656024006699 ABC-ATPase subunit interface; other site 656024006700 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 656024006701 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 656024006702 active site 656024006703 non-prolyl cis peptide bond; other site 656024006704 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 656024006705 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 656024006706 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024006707 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024006708 DNA-binding interface [nucleotide binding]; DNA binding site 656024006709 putative transposase OrfB; Reviewed; Region: PHA02517 656024006710 HTH-like domain; Region: HTH_21; pfam13276 656024006711 Integrase core domain; Region: rve; pfam00665 656024006712 Integrase core domain; Region: rve_3; pfam13683 656024006713 Bacteriophage lambda tail assembly protein I; Region: Lambda_tail_I; cl01945 656024006714 Nuclease-related domain; Region: NERD; pfam08378 656024006715 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 656024006716 ATP binding site [chemical binding]; other site 656024006717 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 656024006718 Protein kinase domain; Region: Pkinase; pfam00069 656024006719 Catalytic domain of Protein Kinases; Region: PKc; cd00180 656024006720 active site 656024006721 ATP binding site [chemical binding]; other site 656024006722 substrate binding site [chemical binding]; other site 656024006723 activation loop (A-loop); other site 656024006724 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 656024006725 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 656024006726 putative active site [active] 656024006727 TIR domain; Region: TIR_2; pfam13676 656024006728 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 656024006729 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 656024006730 active site 656024006731 metal binding site [ion binding]; metal-binding site 656024006732 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 656024006733 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 656024006734 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 656024006735 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 656024006736 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 656024006737 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 656024006738 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 656024006739 hypothetical protein; Provisional; Region: PRK06184 656024006740 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 656024006741 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 656024006742 Chain-length factor (CLF) is a factor required for polyketide chain initiation of aromatic antibiotic-producing polyketide synthases (PKSs) of filamentous bacteria. CLFs have been shown to have decarboxylase activity towards malonyl-acyl carrier protein; Region: CLF; cd00832 656024006743 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 656024006744 active site 656024006745 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 656024006746 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 656024006747 dimer interface [polypeptide binding]; other site 656024006748 active site 656024006749 Cupin domain; Region: Cupin_2; cl17218 656024006750 N-terminal aromatase/cyclase domain of the multifunctional protein tetracenomycin (TcmN) and related domains; Region: TcmN_ARO-CYC_like; cd08860 656024006751 putative hydrophobic ligand binding site [chemical binding]; other site 656024006752 active site 656024006753 catalytic residues_2 [active] 656024006754 catalytic residues_1 [active] 656024006755 Phosphopantetheine attachment site; Region: PP-binding; cl09936 656024006756 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 656024006757 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 656024006758 ATP-grasp domain; Region: ATP-grasp_4; cl17255 656024006759 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 656024006760 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 656024006761 carboxyltransferase (CT) interaction site; other site 656024006762 biotinylation site [posttranslational modification]; other site 656024006763 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 656024006764 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 656024006765 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 656024006766 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673 656024006767 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 656024006768 AAA domain; Region: AAA_30; pfam13604 656024006769 Family description; Region: UvrD_C_2; pfam13538 656024006770 Creatinine amidohydrolase; Region: Creatininase; cl00618 656024006771 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 656024006772 active site 656024006773 classical (c) SDRs; Region: SDR_c; cd05233 656024006774 NAD(P) binding site [chemical binding]; other site 656024006775 active site 656024006776 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 656024006777 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024006778 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 656024006779 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 656024006780 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 656024006781 reverse gyrase; Reviewed; Region: PRK09401 656024006782 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 656024006783 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 656024006784 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 656024006785 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 656024006786 non-specific DNA binding site [nucleotide binding]; other site 656024006787 salt bridge; other site 656024006788 sequence-specific DNA binding site [nucleotide binding]; other site 656024006789 Uncharacterized conserved protein [Function unknown]; Region: COG1359 656024006790 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 656024006791 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 656024006792 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 656024006793 catalytic residue [active] 656024006794 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 656024006795 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 656024006796 ATP binding site [chemical binding]; other site 656024006797 substrate interface [chemical binding]; other site 656024006798 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 656024006799 NifU-like domain; Region: NifU; cl00484 656024006800 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 656024006801 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 656024006802 NifU-like domain; Region: NifU; pfam01106 656024006803 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 656024006804 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 656024006805 FeS/SAM binding site; other site 656024006806 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 656024006807 NifZ domain; Region: NifZ; pfam04319 656024006808 Nitrogen fixation protein NifW; Region: NifW; pfam03206 656024006809 Rop-like; Region: Rop-like; pfam05082 656024006810 Protein of unknown function, DUF269; Region: DUF269; pfam03270 656024006811 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 656024006812 nitrogenase molybdenum-cofactor biosynthesis protein NifN; Provisional; Region: PRK14476 656024006813 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 656024006814 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 656024006815 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 656024006816 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 656024006817 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 656024006818 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 656024006819 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 656024006820 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 656024006821 MoFe protein alpha/beta subunit interactions; other site 656024006822 Alpha subunit P cluster binding residues; other site 656024006823 FeMoco binding residues [chemical binding]; other site 656024006824 MoFe protein alpha subunit/Fe protein contacts; other site 656024006825 MoFe protein dimer/ dimer interactions; other site 656024006826 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 656024006827 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 656024006828 Nucleotide-binding sites [chemical binding]; other site 656024006829 Walker A motif; other site 656024006830 Switch I region of nucleotide binding site; other site 656024006831 Fe4S4 binding sites [ion binding]; other site 656024006832 Switch II region of nucleotide binding site; other site 656024006833 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 656024006834 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 656024006835 active site 656024006836 catalytic residues [active] 656024006837 metal binding site [ion binding]; metal-binding site 656024006838 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 656024006839 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 656024006840 TPP-binding site [chemical binding]; other site 656024006841 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 656024006842 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 656024006843 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 656024006844 dimer interface [polypeptide binding]; other site 656024006845 PYR/PP interface [polypeptide binding]; other site 656024006846 TPP binding site [chemical binding]; other site 656024006847 substrate binding site [chemical binding]; other site 656024006848 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 656024006849 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 656024006850 putative active site [active] 656024006851 seryl-tRNA synthetase; Provisional; Region: PRK05431 656024006852 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 656024006853 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 656024006854 dimer interface [polypeptide binding]; other site 656024006855 active site 656024006856 motif 1; other site 656024006857 motif 2; other site 656024006858 motif 3; other site 656024006859 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 656024006860 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 656024006861 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 656024006862 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 656024006863 active site 656024006864 dimer interface [polypeptide binding]; other site 656024006865 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 656024006866 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 656024006867 active site 656024006868 FMN binding site [chemical binding]; other site 656024006869 substrate binding site [chemical binding]; other site 656024006870 3Fe-4S cluster binding site [ion binding]; other site 656024006871 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 656024006872 domain interface; other site 656024006873 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 656024006874 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 656024006875 substrate binding site [chemical binding]; other site 656024006876 active site 656024006877 catalytic residues [active] 656024006878 heterodimer interface [polypeptide binding]; other site 656024006879 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 656024006880 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 656024006881 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656024006882 catalytic residue [active] 656024006883 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 656024006884 active site 656024006885 ribulose/triose binding site [chemical binding]; other site 656024006886 phosphate binding site [ion binding]; other site 656024006887 substrate (anthranilate) binding pocket [chemical binding]; other site 656024006888 product (indole) binding pocket [chemical binding]; other site 656024006889 anthranilate synthase component I; Provisional; Region: PRK13571 656024006890 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 656024006891 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 656024006892 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 656024006893 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 656024006894 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 656024006895 substrate binding pocket [chemical binding]; other site 656024006896 membrane-bound complex binding site; other site 656024006897 hinge residues; other site 656024006898 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 656024006899 Catalytic domain of Protein Kinases; Region: PKc; cd00180 656024006900 active site 656024006901 ATP binding site [chemical binding]; other site 656024006902 substrate binding site [chemical binding]; other site 656024006903 activation loop (A-loop); other site 656024006904 Double zinc ribbon; Region: DZR; pfam12773 656024006905 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 656024006906 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 656024006907 metal ion-dependent adhesion site (MIDAS); other site 656024006908 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 656024006909 phosphopeptide binding site; other site 656024006910 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 656024006911 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024006912 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 656024006913 Walker A/P-loop; other site 656024006914 ATP binding site [chemical binding]; other site 656024006915 Q-loop/lid; other site 656024006916 ABC transporter signature motif; other site 656024006917 Walker B; other site 656024006918 D-loop; other site 656024006919 H-loop/switch region; other site 656024006920 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 656024006921 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 656024006922 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024006923 Walker A/P-loop; other site 656024006924 ATP binding site [chemical binding]; other site 656024006925 Q-loop/lid; other site 656024006926 ABC transporter signature motif; other site 656024006927 Walker B; other site 656024006928 D-loop; other site 656024006929 H-loop/switch region; other site 656024006930 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 656024006931 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 656024006932 substrate binding site [chemical binding]; other site 656024006933 glutamase interaction surface [polypeptide binding]; other site 656024006934 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 656024006935 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 656024006936 catalytic residues [active] 656024006937 YceI-like domain; Region: YceI; pfam04264 656024006938 H+ Antiporter protein; Region: 2A0121; TIGR00900 656024006939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024006940 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 656024006941 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 656024006942 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024006943 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024006944 DNA-binding interface [nucleotide binding]; DNA binding site 656024006945 putative transposase OrfB; Reviewed; Region: PHA02517 656024006946 HTH-like domain; Region: HTH_21; pfam13276 656024006947 Integrase core domain; Region: rve; pfam00665 656024006948 Integrase core domain; Region: rve_3; pfam13683 656024006949 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 656024006950 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 656024006951 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 656024006952 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 656024006953 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 656024006954 Phosphotransferase enzyme family; Region: APH; pfam01636 656024006955 putative active site [active] 656024006956 putative substrate binding site [chemical binding]; other site 656024006957 ATP binding site [chemical binding]; other site 656024006958 GAF domain; Region: GAF; cl17456 656024006959 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 656024006960 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 656024006961 DNA binding residues [nucleotide binding] 656024006962 dimerization interface [polypeptide binding]; other site 656024006963 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 656024006964 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 656024006965 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 656024006966 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 656024006967 Cytochrome P450; Region: p450; cl12078 656024006968 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 656024006969 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 656024006970 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 656024006971 Soluble P-type ATPase [General function prediction only]; Region: COG4087 656024006972 Transcriptional regulator [Transcription]; Region: LysR; COG0583 656024006973 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 656024006974 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 656024006975 dimerization interface [polypeptide binding]; other site 656024006976 substrate binding pocket [chemical binding]; other site 656024006977 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 656024006978 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 656024006979 FMN-binding pocket [chemical binding]; other site 656024006980 flavin binding motif; other site 656024006981 phosphate binding motif [ion binding]; other site 656024006982 beta-alpha-beta structure motif; other site 656024006983 NAD binding pocket [chemical binding]; other site 656024006984 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 656024006985 catalytic loop [active] 656024006986 iron binding site [ion binding]; other site 656024006987 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 656024006988 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024006989 Walker A/P-loop; other site 656024006990 ATP binding site [chemical binding]; other site 656024006991 Q-loop/lid; other site 656024006992 ABC transporter signature motif; other site 656024006993 Walker B; other site 656024006994 D-loop; other site 656024006995 H-loop/switch region; other site 656024006996 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 656024006997 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 656024006998 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 656024006999 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 656024007000 active site 656024007001 metal binding site [ion binding]; metal-binding site 656024007002 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 656024007003 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024007004 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024007005 DNA-binding interface [nucleotide binding]; DNA binding site 656024007006 putative transposase OrfB; Reviewed; Region: PHA02517 656024007007 HTH-like domain; Region: HTH_21; pfam13276 656024007008 Integrase core domain; Region: rve; pfam00665 656024007009 Integrase core domain; Region: rve_3; pfam13683 656024007010 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 656024007011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 656024007012 dimer interface [polypeptide binding]; other site 656024007013 conserved gate region; other site 656024007014 putative PBP binding loops; other site 656024007015 ABC-ATPase subunit interface; other site 656024007016 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 656024007017 Transposase; Region: DDE_Tnp_ISL3; pfam01610 656024007018 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 656024007019 SnoaL-like domain; Region: SnoaL_2; pfam12680 656024007020 Cytochrome P450; Region: p450; cl12078 656024007021 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 656024007022 Homeodomain-like domain; Region: HTH_23; pfam13384 656024007023 Winged helix-turn helix; Region: HTH_29; pfam13551 656024007024 Homeodomain-like domain; Region: HTH_32; pfam13565 656024007025 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024007026 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 656024007027 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 656024007028 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 656024007029 NAD(P) binding site [chemical binding]; other site 656024007030 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 656024007031 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 656024007032 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 656024007033 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 656024007034 acyl-activating enzyme (AAE) consensus motif; other site 656024007035 AMP binding site [chemical binding]; other site 656024007036 active site 656024007037 CoA binding site [chemical binding]; other site 656024007038 Cupin domain; Region: Cupin_2; cl17218 656024007039 Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: MetG; COG0143 656024007040 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 656024007041 active site 656024007042 HIGH motif; other site 656024007043 nucleotide binding site [chemical binding]; other site 656024007044 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 656024007045 active site 656024007046 KMSKS motif; other site 656024007047 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 656024007048 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 656024007049 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 656024007050 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 656024007051 active site 656024007052 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 656024007053 active site 656024007054 catalytic triad [active] 656024007055 oxyanion hole [active] 656024007056 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 656024007057 dinuclear metal binding motif [ion binding]; other site 656024007058 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 656024007059 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 656024007060 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 656024007061 acyl-activating enzyme (AAE) consensus motif; other site 656024007062 active site 656024007063 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 656024007064 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 656024007065 ATP-grasp domain; Region: ATP-grasp_4; cl17255 656024007066 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 656024007067 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 656024007068 carboxyltransferase (CT) interaction site; other site 656024007069 biotinylation site [posttranslational modification]; other site 656024007070 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 656024007071 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 656024007072 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 656024007073 FMN binding site [chemical binding]; other site 656024007074 substrate binding site [chemical binding]; other site 656024007075 putative catalytic residue [active] 656024007076 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 656024007077 active site 1 [active] 656024007078 dimer interface [polypeptide binding]; other site 656024007079 active site 2 [active] 656024007080 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 656024007081 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 656024007082 active site 656024007083 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 656024007084 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 656024007085 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 656024007086 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 656024007087 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 656024007088 putative NADP binding site [chemical binding]; other site 656024007089 active site 656024007090 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 656024007091 active site 656024007092 catalytic triad [active] 656024007093 oxyanion hole [active] 656024007094 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 656024007095 CoenzymeA binding site [chemical binding]; other site 656024007096 subunit interaction site [polypeptide binding]; other site 656024007097 PHB binding site; other site 656024007098 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024007099 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024007100 DNA-binding interface [nucleotide binding]; DNA binding site 656024007101 putative transposase OrfB; Reviewed; Region: PHA02517 656024007102 HTH-like domain; Region: HTH_21; pfam13276 656024007103 Integrase core domain; Region: rve; pfam00665 656024007104 Integrase core domain; Region: rve_3; pfam13683 656024007105 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 656024007106 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 656024007107 active site 656024007108 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 656024007109 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 656024007110 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 656024007111 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 656024007112 acyl-activating enzyme (AAE) consensus motif; other site 656024007113 putative AMP binding site [chemical binding]; other site 656024007114 putative active site [active] 656024007115 putative CoA binding site [chemical binding]; other site 656024007116 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 656024007117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024007118 putative substrate translocation pore; other site 656024007119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 656024007120 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 656024007121 Coenzyme A binding pocket [chemical binding]; other site 656024007122 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 656024007123 CoenzymeA binding site [chemical binding]; other site 656024007124 subunit interaction site [polypeptide binding]; other site 656024007125 PHB binding site; other site 656024007126 epoxide hydrolase N-terminal domain-like phosphatase; Region: HAD-1A3-hyp; TIGR02247 656024007127 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 656024007128 motif II; other site 656024007129 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 656024007130 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 656024007131 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 656024007132 acyl-activating enzyme (AAE) consensus motif; other site 656024007133 active site 656024007134 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 656024007135 dinuclear metal binding motif [ion binding]; other site 656024007136 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 656024007137 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 656024007138 dinuclear metal binding motif [ion binding]; other site 656024007139 MarR family; Region: MarR; pfam01047 656024007140 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 656024007141 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656024007142 PAS fold; Region: PAS_3; pfam08447 656024007143 putative active site [active] 656024007144 heme pocket [chemical binding]; other site 656024007145 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656024007146 PAS domain; Region: PAS_9; pfam13426 656024007147 putative active site [active] 656024007148 heme pocket [chemical binding]; other site 656024007149 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 656024007150 GAF domain; Region: GAF; pfam01590 656024007151 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 656024007152 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 656024007153 Protein of unknown function (DUF445); Region: DUF445; pfam04286 656024007154 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 656024007155 DEAD-like helicases superfamily; Region: DEXDc; smart00487 656024007156 ATP binding site [chemical binding]; other site 656024007157 Mg++ binding site [ion binding]; other site 656024007158 motif III; other site 656024007159 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 656024007160 nucleotide binding region [chemical binding]; other site 656024007161 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 656024007162 putative active site [active] 656024007163 L-lysine aminotransferase; Provisional; Region: PRK08297 656024007164 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 656024007165 inhibitor-cofactor binding pocket; inhibition site 656024007166 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656024007167 catalytic residue [active] 656024007168 Protein kinase domain; Region: Pkinase; pfam00069 656024007169 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 656024007170 active site 656024007171 ATP binding site [chemical binding]; other site 656024007172 substrate binding site [chemical binding]; other site 656024007173 activation loop (A-loop); other site 656024007174 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 656024007175 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656024007176 active site 656024007177 Fic/DOC family; Region: Fic; cl00960 656024007178 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 656024007179 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 656024007180 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 656024007181 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024007182 Walker B; other site 656024007183 D-loop; other site 656024007184 H-loop/switch region; other site 656024007185 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 656024007186 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 656024007187 putative active site [active] 656024007188 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 656024007189 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 656024007190 DNA binding residues [nucleotide binding] 656024007191 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 656024007192 Prostaglandin dehydrogenases; Region: PGDH; cd05288 656024007193 NAD(P) binding site [chemical binding]; other site 656024007194 substrate binding site [chemical binding]; other site 656024007195 dimer interface [polypeptide binding]; other site 656024007196 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 656024007197 putative active site [active] 656024007198 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 656024007199 Uncharacterized conserved protein [Function unknown]; Region: COG1262 656024007200 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 656024007201 Archaeal ATPase; Region: Arch_ATPase; pfam01637 656024007202 Fic family protein [Function unknown]; Region: COG3177 656024007203 Fic/DOC family; Region: Fic; pfam02661 656024007204 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 656024007205 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 656024007206 oligomeric interface; other site 656024007207 putative active site [active] 656024007208 homodimer interface [polypeptide binding]; other site 656024007209 NmrA-like family; Region: NmrA; pfam05368 656024007210 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 656024007211 NADP binding site [chemical binding]; other site 656024007212 active site 656024007213 regulatory binding site [polypeptide binding]; other site 656024007214 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 656024007215 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 656024007216 conserved cys residue [active] 656024007217 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 656024007218 YcfA-like protein; Region: YcfA; cl00752 656024007219 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 656024007220 active site 656024007221 NTP binding site [chemical binding]; other site 656024007222 metal binding triad [ion binding]; metal-binding site 656024007223 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 656024007224 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 656024007225 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 656024007226 putative active site [active] 656024007227 homotetrameric interface [polypeptide binding]; other site 656024007228 metal binding site [ion binding]; metal-binding site 656024007229 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 656024007230 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 656024007231 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 656024007232 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 656024007233 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 656024007234 putative metal binding site [ion binding]; other site 656024007235 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 656024007236 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 656024007237 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 656024007238 active site 656024007239 catalytic tetrad [active] 656024007240 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 656024007241 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 656024007242 SpoOM protein; Region: Spo0M; pfam07070 656024007243 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 656024007244 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 656024007245 Catalytic domain of Protein Kinases; Region: PKc; cd00180 656024007246 active site 656024007247 ATP binding site [chemical binding]; other site 656024007248 substrate binding site [chemical binding]; other site 656024007249 activation loop (A-loop); other site 656024007250 NHL repeat; Region: NHL; pfam01436 656024007251 NHL repeat; Region: NHL; pfam01436 656024007252 NHL repeat; Region: NHL; pfam01436 656024007253 NHL repeat; Region: NHL; pfam01436 656024007254 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 656024007255 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 656024007256 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 656024007257 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 656024007258 Catalytic domain of Protein Kinases; Region: PKc; cd00180 656024007259 active site 656024007260 ATP binding site [chemical binding]; other site 656024007261 substrate binding site [chemical binding]; other site 656024007262 activation loop (A-loop); other site 656024007263 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 656024007264 active site 656024007265 FOG: WD40-like repeat [Function unknown]; Region: COG1520 656024007266 Trp docking motif [polypeptide binding]; other site 656024007267 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 656024007268 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 656024007269 active site 656024007270 metal binding site [ion binding]; metal-binding site 656024007271 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 656024007272 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 656024007273 Transcriptional regulators [Transcription]; Region: FadR; COG2186 656024007274 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 656024007275 DNA-binding site [nucleotide binding]; DNA binding site 656024007276 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 656024007277 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 656024007278 active site 656024007279 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 656024007280 catalytic triad [active] 656024007281 dimer interface [polypeptide binding]; other site 656024007282 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 656024007283 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 656024007284 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 656024007285 Soluble P-type ATPase [General function prediction only]; Region: COG4087 656024007286 K+-transporting ATPase, c chain; Region: KdpC; cl00944 656024007287 K+-transporting ATPase, c chain; Region: KdpC; cl00944 656024007288 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 656024007289 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 656024007290 active site 656024007291 phosphorylation site [posttranslational modification] 656024007292 intermolecular recognition site; other site 656024007293 dimerization interface [polypeptide binding]; other site 656024007294 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 656024007295 DNA binding site [nucleotide binding] 656024007296 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 656024007297 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 656024007298 [2Fe-2S] cluster binding site [ion binding]; other site 656024007299 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 656024007300 alpha subunit interface [polypeptide binding]; other site 656024007301 active site 656024007302 substrate binding site [chemical binding]; other site 656024007303 Fe binding site [ion binding]; other site 656024007304 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 656024007305 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 656024007306 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 656024007307 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 656024007308 active site 656024007309 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 656024007310 CoA-transferase family III; Region: CoA_transf_3; pfam02515 656024007311 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 656024007312 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 656024007313 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 656024007314 acyl-activating enzyme (AAE) consensus motif; other site 656024007315 putative AMP binding site [chemical binding]; other site 656024007316 putative active site [active] 656024007317 putative CoA binding site [chemical binding]; other site 656024007318 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 656024007319 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 656024007320 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 656024007321 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656024007322 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024007323 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 656024007324 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 656024007325 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 656024007326 acyl-activating enzyme (AAE) consensus motif; other site 656024007327 acyl-activating enzyme (AAE) consensus motif; other site 656024007328 putative AMP binding site [chemical binding]; other site 656024007329 putative active site [active] 656024007330 putative CoA binding site [chemical binding]; other site 656024007331 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 656024007332 Amidohydrolase; Region: Amidohydro_2; pfam04909 656024007333 Domain of unknown function DUF59; Region: DUF59; pfam01883 656024007334 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 656024007335 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 656024007336 substrate binding site [chemical binding]; other site 656024007337 oxyanion hole (OAH) forming residues; other site 656024007338 trimer interface [polypeptide binding]; other site 656024007339 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 656024007340 active site 2 [active] 656024007341 active site 1 [active] 656024007342 thiolase; Provisional; Region: PRK06158 656024007343 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 656024007344 active site 656024007345 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 656024007346 DUF35 OB-fold domain; Region: DUF35; pfam01796 656024007347 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 656024007348 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 656024007349 active site 656024007350 enoyl-CoA hydratase; Provisional; Region: PRK09245 656024007351 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 656024007352 substrate binding site [chemical binding]; other site 656024007353 oxyanion hole (OAH) forming residues; other site 656024007354 trimer interface [polypeptide binding]; other site 656024007355 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 656024007356 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 656024007357 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 656024007358 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 656024007359 Ligand Binding Site [chemical binding]; other site 656024007360 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 656024007361 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 656024007362 dimer interface [polypeptide binding]; other site 656024007363 phosphorylation site [posttranslational modification] 656024007364 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656024007365 ATP binding site [chemical binding]; other site 656024007366 Mg2+ binding site [ion binding]; other site 656024007367 G-X-G motif; other site 656024007368 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 656024007369 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 656024007370 Walker A/P-loop; other site 656024007371 ATP binding site [chemical binding]; other site 656024007372 Q-loop/lid; other site 656024007373 ABC transporter signature motif; other site 656024007374 Walker B; other site 656024007375 D-loop; other site 656024007376 H-loop/switch region; other site 656024007377 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 656024007378 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 656024007379 Walker A/P-loop; other site 656024007380 ATP binding site [chemical binding]; other site 656024007381 Q-loop/lid; other site 656024007382 ABC transporter signature motif; other site 656024007383 Walker B; other site 656024007384 D-loop; other site 656024007385 H-loop/switch region; other site 656024007386 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 656024007387 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656024007388 PAS fold; Region: PAS_3; pfam08447 656024007389 putative active site [active] 656024007390 heme pocket [chemical binding]; other site 656024007391 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 656024007392 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656024007393 metal binding site [ion binding]; metal-binding site 656024007394 active site 656024007395 I-site; other site 656024007396 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 656024007397 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 656024007398 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 656024007399 heme binding site [chemical binding]; other site 656024007400 ferroxidase pore; other site 656024007401 ferroxidase diiron center [ion binding]; other site 656024007402 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 656024007403 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 656024007404 active site 656024007405 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 656024007406 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 656024007407 ligand binding site [chemical binding]; other site 656024007408 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 656024007409 active site 656024007410 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 656024007411 Fatty acid desaturase; Region: FA_desaturase; pfam00487 656024007412 Di-iron ligands [ion binding]; other site 656024007413 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 656024007414 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 656024007415 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 656024007416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 656024007417 S-adenosylmethionine binding site [chemical binding]; other site 656024007418 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 656024007419 Cytochrome P450; Region: p450; cl12078 656024007420 acyl-CoA synthetase; Validated; Region: PRK05850 656024007421 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 656024007422 acyl-activating enzyme (AAE) consensus motif; other site 656024007423 active site 656024007424 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 656024007425 CoenzymeA binding site [chemical binding]; other site 656024007426 subunit interaction site [polypeptide binding]; other site 656024007427 PHB binding site; other site 656024007428 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 656024007429 Cytochrome P450; Region: p450; cl12078 656024007430 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 656024007431 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 656024007432 nucleophilic elbow; other site 656024007433 catalytic triad; other site 656024007434 TAP-like protein; Region: Abhydrolase_4; pfam08386 656024007435 Tetratricopeptide repeat; Region: TPR_10; cl17452 656024007436 Predicted transcriptional regulators [Transcription]; Region: COG1695 656024007437 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 656024007438 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 656024007439 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 656024007440 RNA/DNA hybrid binding site [nucleotide binding]; other site 656024007441 active site 656024007442 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 656024007443 catalytic core [active] 656024007444 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 656024007445 Putative zinc ribbon domain; Region: DUF164; pfam02591 656024007446 Uncharacterized conserved protein [Function unknown]; Region: COG0327 656024007447 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 656024007448 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 656024007449 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 656024007450 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 656024007451 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024007452 Walker A/P-loop; other site 656024007453 ATP binding site [chemical binding]; other site 656024007454 Q-loop/lid; other site 656024007455 ABC transporter signature motif; other site 656024007456 Walker B; other site 656024007457 D-loop; other site 656024007458 H-loop/switch region; other site 656024007459 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 656024007460 Ligand binding site; other site 656024007461 Putative Catalytic site; other site 656024007462 DXD motif; other site 656024007463 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 656024007464 active site 656024007465 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 656024007466 DNA binding site [nucleotide binding] 656024007467 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 656024007468 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 656024007469 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 656024007470 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 656024007471 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 656024007472 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 656024007473 active site 656024007474 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 656024007475 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 656024007476 dimer interface [polypeptide binding]; other site 656024007477 active site 656024007478 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 656024007479 active site 656024007480 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 656024007481 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 656024007482 dimer interface [polypeptide binding]; other site 656024007483 active site 656024007484 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 656024007485 active site 2 [active] 656024007486 active site 1 [active] 656024007487 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 656024007488 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 656024007489 dimer interface [polypeptide binding]; other site 656024007490 active site 656024007491 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 656024007492 active site 2 [active] 656024007493 active site 1 [active] 656024007494 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 656024007495 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656024007496 NAD(P) binding site [chemical binding]; other site 656024007497 active site 656024007498 Phosphopantetheine attachment site; Region: PP-binding; cl09936 656024007499 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 656024007500 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 656024007501 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 656024007502 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 656024007503 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 656024007504 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 656024007505 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 656024007506 RNA binding surface [nucleotide binding]; other site 656024007507 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 656024007508 active site 656024007509 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 656024007510 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 656024007511 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 656024007512 active site 656024007513 HIGH motif; other site 656024007514 nucleotide binding site [chemical binding]; other site 656024007515 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 656024007516 active site 656024007517 KMSKS motif; other site 656024007518 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 656024007519 tRNA binding surface [nucleotide binding]; other site 656024007520 anticodon binding site; other site 656024007521 DivIVA protein; Region: DivIVA; pfam05103 656024007522 DivIVA domain; Region: DivI1A_domain; TIGR03544 656024007523 Protein of unknown function (DUF552); Region: DUF552; pfam04472 656024007524 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 656024007525 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 656024007526 catalytic residue [active] 656024007527 cell division protein FtsZ; Validated; Region: PRK09330 656024007528 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 656024007529 nucleotide binding site [chemical binding]; other site 656024007530 SulA interaction site; other site 656024007531 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 656024007532 cyclase homology domain; Region: CHD; cd07302 656024007533 nucleotidyl binding site; other site 656024007534 metal binding site [ion binding]; metal-binding site 656024007535 dimer interface [polypeptide binding]; other site 656024007536 Archaeal ATPase; Region: Arch_ATPase; pfam01637 656024007537 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 656024007538 Walker A motif; other site 656024007539 ATP binding site [chemical binding]; other site 656024007540 Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism]; Region: PhaC; COG3243 656024007541 PemK-like protein; Region: PemK; pfam02452 656024007542 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 656024007543 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 656024007544 phosphopeptide binding site; other site 656024007545 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 656024007546 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 656024007547 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 656024007548 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 656024007549 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 656024007550 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024007551 Transposase; Region: HTH_Tnp_1; pfam01527 656024007552 HTH-like domain; Region: HTH_21; pfam13276 656024007553 Integrase core domain; Region: rve; pfam00665 656024007554 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 656024007555 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 656024007556 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 656024007557 Putative catalytic domain of rhizobial NodB chitooligosaccharide N-deacetylase and its bacterial homologs; Region: CE4_NodB; cd10943 656024007558 NodB motif; other site 656024007559 putative active site [active] 656024007560 putative catalytic site [active] 656024007561 putative Zn binding site [ion binding]; other site 656024007562 chitooligosaccharide synthase NodC; Region: nodulat_NodC; TIGR04242 656024007563 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 656024007564 DXD motif; other site 656024007565 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024007566 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 656024007567 Walker A/P-loop; other site 656024007568 ATP binding site [chemical binding]; other site 656024007569 Q-loop/lid; other site 656024007570 ABC transporter signature motif; other site 656024007571 Walker B; other site 656024007572 D-loop; other site 656024007573 H-loop/switch region; other site 656024007574 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 656024007575 ABC-2 type transporter; Region: ABC2_membrane; cl17235 656024007576 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 656024007577 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 656024007578 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 656024007579 RHS Repeat; Region: RHS_repeat; pfam05593 656024007580 RHS Repeat; Region: RHS_repeat; cl11982 656024007581 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 656024007582 RHS Repeat; Region: RHS_repeat; pfam05593 656024007583 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 656024007584 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 656024007585 RHS Repeat; Region: RHS_repeat; pfam05593 656024007586 RHS Repeat; Region: RHS_repeat; pfam05593 656024007587 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 656024007588 RHS Repeat; Region: RHS_repeat; cl11982 656024007589 RHS Repeat; Region: RHS_repeat; cl11982 656024007590 RHS protein; Region: RHS; pfam03527 656024007591 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 656024007592 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 656024007593 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 656024007594 Catalytic domain of Protein Kinases; Region: PKc; cd00180 656024007595 active site 656024007596 ATP binding site [chemical binding]; other site 656024007597 substrate binding site [chemical binding]; other site 656024007598 activation loop (A-loop); other site 656024007599 Domain of unknown function (DUF385); Region: DUF385; cl04387 656024007600 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 656024007601 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 656024007602 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 656024007603 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 656024007604 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 656024007605 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 656024007606 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 656024007607 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 656024007608 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 656024007609 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 656024007610 active site 656024007611 homodimer interface [polypeptide binding]; other site 656024007612 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_15; cd12180 656024007613 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 656024007614 putative ligand binding site [chemical binding]; other site 656024007615 putative NAD binding site [chemical binding]; other site 656024007616 catalytic site [active] 656024007617 cell division protein FtsW; Region: ftsW; TIGR02614 656024007618 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 656024007619 FAD binding domain; Region: FAD_binding_4; pfam01565 656024007620 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 656024007621 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 656024007622 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 656024007623 Ligand Binding Site [chemical binding]; other site 656024007624 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK04690 656024007625 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 656024007626 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 656024007627 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 656024007628 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 656024007629 Mg++ binding site [ion binding]; other site 656024007630 putative catalytic motif [active] 656024007631 putative substrate binding site [chemical binding]; other site 656024007632 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 656024007633 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 656024007634 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 656024007635 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 656024007636 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 656024007637 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 656024007638 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 656024007639 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 656024007640 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 656024007641 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 656024007642 MraW methylase family; Region: Methyltransf_5; cl17771 656024007643 cell division protein MraZ; Reviewed; Region: PRK00326 656024007644 MraZ protein; Region: MraZ; pfam02381 656024007645 MraZ protein; Region: MraZ; pfam02381 656024007646 MoxR-like ATPases [General function prediction only]; Region: COG0714 656024007647 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 656024007648 Walker A motif; other site 656024007649 ATP binding site [chemical binding]; other site 656024007650 Walker B motif; other site 656024007651 arginine finger; other site 656024007652 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 656024007653 Protein of unknown function DUF58; Region: DUF58; pfam01882 656024007654 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 656024007655 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 656024007656 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 656024007657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 656024007658 S-adenosylmethionine binding site [chemical binding]; other site 656024007659 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 656024007660 Coenzyme A binding pocket [chemical binding]; other site 656024007661 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 656024007662 FAD binding site [chemical binding]; other site 656024007663 MoxR-like ATPases [General function prediction only]; Region: COG0714 656024007664 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 656024007665 Walker A motif; other site 656024007666 ATP binding site [chemical binding]; other site 656024007667 Walker B motif; other site 656024007668 arginine finger; other site 656024007669 Protein of unknown function DUF58; Region: DUF58; pfam01882 656024007670 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 656024007671 von Willebrand factor type A domain; Region: VWA_2; pfam13519 656024007672 metal ion-dependent adhesion site (MIDAS); other site 656024007673 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 656024007674 DNA-binding site [nucleotide binding]; DNA binding site 656024007675 RNA-binding motif; other site 656024007676 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 656024007677 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024007678 Walker A/P-loop; other site 656024007679 ATP binding site [chemical binding]; other site 656024007680 Q-loop/lid; other site 656024007681 ABC transporter signature motif; other site 656024007682 Walker B; other site 656024007683 D-loop; other site 656024007684 H-loop/switch region; other site 656024007685 TOBE domain; Region: TOBE; pfam03459 656024007686 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 656024007687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 656024007688 dimer interface [polypeptide binding]; other site 656024007689 conserved gate region; other site 656024007690 putative PBP binding loops; other site 656024007691 ABC-ATPase subunit interface; other site 656024007692 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 656024007693 DNA binding residues [nucleotide binding] 656024007694 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 656024007695 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 656024007696 thiamine phosphate binding site [chemical binding]; other site 656024007697 active site 656024007698 pyrophosphate binding site [ion binding]; other site 656024007699 Helix-turn-helix domain; Region: HTH_17; pfam12728 656024007700 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 656024007701 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 656024007702 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 656024007703 Protein of unknown function, DUF393; Region: DUF393; cl01136 656024007704 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 656024007705 Catalytic domain of Protein Kinases; Region: PKc; cd00180 656024007706 active site 656024007707 ATP binding site [chemical binding]; other site 656024007708 substrate binding site [chemical binding]; other site 656024007709 activation loop (A-loop); other site 656024007710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 656024007711 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 656024007712 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 656024007713 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 656024007714 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 656024007715 phosphofructokinase; Region: PFK_mixed; TIGR02483 656024007716 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 656024007717 active site 656024007718 ADP/pyrophosphate binding site [chemical binding]; other site 656024007719 dimerization interface [polypeptide binding]; other site 656024007720 allosteric effector site; other site 656024007721 fructose-1,6-bisphosphate binding site; other site 656024007722 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 656024007723 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 656024007724 putative acyl-acceptor binding pocket; other site 656024007725 Esterase/lipase [General function prediction only]; Region: COG1647 656024007726 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144 656024007727 Uncharacterized conserved protein [Function unknown]; Region: COG1915 656024007728 homodimer interface [polypeptide binding]; other site 656024007729 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 656024007730 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 656024007731 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 656024007732 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 656024007733 DTAP/Switch II; other site 656024007734 Switch I; other site 656024007735 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 656024007736 putative hydrophobic ligand binding site [chemical binding]; other site 656024007737 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 656024007738 active site 656024007739 metal binding site [ion binding]; metal-binding site 656024007740 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 656024007741 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 656024007742 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 656024007743 Respiratory burst NADPH oxidase; Region: NADPH_Ox; pfam08414 656024007744 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 656024007745 putative active site [active] 656024007746 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304 656024007747 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 656024007748 putative active site [active] 656024007749 homotetrameric interface [polypeptide binding]; other site 656024007750 metal binding site [ion binding]; metal-binding site 656024007751 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 656024007752 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 656024007753 non-specific DNA binding site [nucleotide binding]; other site 656024007754 salt bridge; other site 656024007755 sequence-specific DNA binding site [nucleotide binding]; other site 656024007756 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 656024007757 YacP-like NYN domain; Region: NYN_YacP; cl01491 656024007758 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 656024007759 nucleotide binding site/active site [active] 656024007760 HIT family signature motif; other site 656024007761 catalytic residue [active] 656024007762 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 656024007763 active site 656024007764 hypothetical protein; Validated; Region: PRK07883 656024007765 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 656024007766 active site 656024007767 catalytic site [active] 656024007768 substrate binding site [chemical binding]; other site 656024007769 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 656024007770 GIY-YIG motif/motif A; other site 656024007771 active site 656024007772 catalytic site [active] 656024007773 putative DNA binding site [nucleotide binding]; other site 656024007774 metal binding site [ion binding]; metal-binding site 656024007775 ABC-2 type transporter; Region: ABC2_membrane; cl17235 656024007776 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 656024007777 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 656024007778 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024007779 Walker A/P-loop; other site 656024007780 ATP binding site [chemical binding]; other site 656024007781 Q-loop/lid; other site 656024007782 ABC transporter signature motif; other site 656024007783 Walker B; other site 656024007784 D-loop; other site 656024007785 H-loop/switch region; other site 656024007786 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 656024007787 intrachain domain interface; other site 656024007788 heme bH binding site [chemical binding]; other site 656024007789 heme bL binding site [chemical binding]; other site 656024007790 interchain domain interface [polypeptide binding]; other site 656024007791 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 656024007792 Qo binding site; other site 656024007793 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 656024007794 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 656024007795 iron-sulfur cluster [ion binding]; other site 656024007796 [2Fe-2S] cluster binding site [ion binding]; other site 656024007797 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 656024007798 Cytochrome c; Region: Cytochrom_C; pfam00034 656024007799 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 656024007800 Subunit I/III interface [polypeptide binding]; other site 656024007801 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 656024007802 Protein of unknown function (DUF3501); Region: DUF3501; pfam12007 656024007803 Rubrerythrin [Energy production and conversion]; Region: COG1592 656024007804 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 656024007805 binuclear metal center [ion binding]; other site 656024007806 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 656024007807 metal binding site 2 [ion binding]; metal-binding site 656024007808 putative DNA binding helix; other site 656024007809 metal binding site 1 [ion binding]; metal-binding site 656024007810 dimer interface [polypeptide binding]; other site 656024007811 structural Zn2+ binding site [ion binding]; other site 656024007812 Response regulator receiver domain; Region: Response_reg; pfam00072 656024007813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 656024007814 active site 656024007815 phosphorylation site [posttranslational modification] 656024007816 intermolecular recognition site; other site 656024007817 dimerization interface [polypeptide binding]; other site 656024007818 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 656024007819 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 656024007820 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 656024007821 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 656024007822 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 656024007823 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 656024007824 D-pathway; other site 656024007825 Putative ubiquinol binding site [chemical binding]; other site 656024007826 Low-spin heme (heme b) binding site [chemical binding]; other site 656024007827 Putative water exit pathway; other site 656024007828 Binuclear center (heme o3/CuB) [ion binding]; other site 656024007829 K-pathway; other site 656024007830 Putative proton exit pathway; other site 656024007831 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 656024007832 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 656024007833 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 656024007834 putative active site [active] 656024007835 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 656024007836 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 656024007837 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 656024007838 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 656024007839 catalytic residue [active] 656024007840 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 656024007841 CPxP motif; other site 656024007842 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 656024007843 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 656024007844 substrate binding site [chemical binding]; other site 656024007845 ATP binding site [chemical binding]; other site 656024007846 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 656024007847 quinolinate synthetase; Provisional; Region: PRK09375 656024007848 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 656024007849 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 656024007850 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 656024007851 active site 656024007852 catalytic tetrad [active] 656024007853 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 656024007854 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 656024007855 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 656024007856 homotrimer interface [polypeptide binding]; other site 656024007857 Walker A motif; other site 656024007858 GTP binding site [chemical binding]; other site 656024007859 Walker B motif; other site 656024007860 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 656024007861 nucleoside/Zn binding site; other site 656024007862 dimer interface [polypeptide binding]; other site 656024007863 catalytic motif [active] 656024007864 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 656024007865 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 656024007866 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 656024007867 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 656024007868 active site 656024007869 non-prolyl cis peptide bond; other site 656024007870 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 656024007871 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 656024007872 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 656024007873 non-specific DNA binding site [nucleotide binding]; other site 656024007874 salt bridge; other site 656024007875 sequence-specific DNA binding site [nucleotide binding]; other site 656024007876 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656024007877 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 656024007878 NAD(P) binding site [chemical binding]; other site 656024007879 active site 656024007880 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656024007881 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024007882 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 656024007883 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 656024007884 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cl11435 656024007885 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 656024007886 active site pocket [active] 656024007887 cobalamin synthase; Reviewed; Region: cobS; PRK00235 656024007888 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 656024007889 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 656024007890 Cytosol aminopeptidase family, N-terminal domain; Region: Peptidase_M17_N; pfam02789 656024007891 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 656024007892 multifunctional aminopeptidase A; Provisional; Region: PRK00913 656024007893 interface (dimer of trimers) [polypeptide binding]; other site 656024007894 Substrate-binding/catalytic site; other site 656024007895 Zn-binding sites [ion binding]; other site 656024007896 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 656024007897 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 656024007898 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 656024007899 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 656024007900 E3 interaction surface; other site 656024007901 lipoyl attachment site [posttranslational modification]; other site 656024007902 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 656024007903 e3 binding domain; Region: E3_binding; pfam02817 656024007904 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 656024007905 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656024007906 TIGR01777 family protein; Region: yfcH 656024007907 NAD(P) binding site [chemical binding]; other site 656024007908 active site 656024007909 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 656024007910 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 656024007911 active site pocket [active] 656024007912 oxyanion hole [active] 656024007913 catalytic triad [active] 656024007914 active site nucleophile [active] 656024007915 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 656024007916 lipoyl synthase; Provisional; Region: PRK05481 656024007917 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 656024007918 FeS/SAM binding site; other site 656024007919 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 656024007920 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 656024007921 RDD family; Region: RDD; pfam06271 656024007922 glutamine synthetase, type I; Region: GlnA; TIGR00653 656024007923 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 656024007924 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 656024007925 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 656024007926 glutamine synthetase; Region: PLN02284 656024007927 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 656024007928 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 656024007929 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 656024007930 metal binding triad; other site 656024007931 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 656024007932 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 656024007933 metal binding triad; other site 656024007934 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 656024007935 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 656024007936 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 656024007937 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 656024007938 NAD synthetase; Provisional; Region: PRK13981 656024007939 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 656024007940 multimer interface [polypeptide binding]; other site 656024007941 active site 656024007942 catalytic triad [active] 656024007943 protein interface 1 [polypeptide binding]; other site 656024007944 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 656024007945 homodimer interface [polypeptide binding]; other site 656024007946 NAD binding pocket [chemical binding]; other site 656024007947 ATP binding pocket [chemical binding]; other site 656024007948 Mg binding site [ion binding]; other site 656024007949 active-site loop [active] 656024007950 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656024007951 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024007952 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 656024007953 oligomerization interface [polypeptide binding]; other site 656024007954 active site 656024007955 metal binding site [ion binding]; metal-binding site 656024007956 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 656024007957 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024007958 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024007959 DNA-binding interface [nucleotide binding]; DNA binding site 656024007960 putative transposase OrfB; Reviewed; Region: PHA02517 656024007961 HTH-like domain; Region: HTH_21; pfam13276 656024007962 Integrase core domain; Region: rve; pfam00665 656024007963 Integrase core domain; Region: rve_3; pfam13683 656024007964 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024007965 Transposase; Region: HTH_Tnp_1; pfam01527 656024007966 putative transposase OrfB; Reviewed; Region: PHA02517 656024007967 HTH-like domain; Region: HTH_21; pfam13276 656024007968 Integrase core domain; Region: rve; pfam00665 656024007969 Integrase core domain; Region: rve_3; pfam13683 656024007970 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 656024007971 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 656024007972 intersubunit interface [polypeptide binding]; other site 656024007973 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 656024007974 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 656024007975 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 656024007976 active site 656024007977 DNA binding site [nucleotide binding] 656024007978 Int/Topo IB signature motif; other site 656024007979 PKD domain; Region: PKD; pfam00801 656024007980 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 656024007981 dimer interface [polypeptide binding]; other site 656024007982 ADP-ribose binding site [chemical binding]; other site 656024007983 active site 656024007984 nudix motif; other site 656024007985 metal binding site [ion binding]; metal-binding site 656024007986 CTP synthetase; Validated; Region: pyrG; PRK05380 656024007987 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 656024007988 Catalytic site [active] 656024007989 active site 656024007990 UTP binding site [chemical binding]; other site 656024007991 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 656024007992 active site 656024007993 putative oxyanion hole; other site 656024007994 catalytic triad [active] 656024007995 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 656024007996 putative FMN binding site [chemical binding]; other site 656024007997 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 656024007998 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 656024007999 Walker A/P-loop; other site 656024008000 ATP binding site [chemical binding]; other site 656024008001 Q-loop/lid; other site 656024008002 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 656024008003 ABC transporter signature motif; other site 656024008004 Walker B; other site 656024008005 D-loop; other site 656024008006 H-loop/switch region; other site 656024008007 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 656024008008 ATP-NAD kinase; Region: NAD_kinase; pfam01513 656024008009 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 656024008010 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 656024008011 RNA binding surface [nucleotide binding]; other site 656024008012 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 656024008013 S-adenosylmethionine binding site [chemical binding]; other site 656024008014 SCP-2 sterol transfer family; Region: SCP2; pfam02036 656024008015 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 656024008016 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 656024008017 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 656024008018 Tetratricopeptide repeat; Region: TPR_16; pfam13432 656024008019 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 656024008020 TPR motif; other site 656024008021 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 656024008022 Uncharacterized conserved protein [Function unknown]; Region: COG4198 656024008023 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 656024008024 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 656024008025 putative NAD(P) binding site [chemical binding]; other site 656024008026 Predicted transcriptional regulators [Transcription]; Region: COG1733 656024008027 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 656024008028 Predicted transcriptional regulators [Transcription]; Region: COG1733 656024008029 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 656024008030 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 656024008031 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 656024008032 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 656024008033 argininosuccinate lyase; Provisional; Region: PRK00855 656024008034 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 656024008035 active sites [active] 656024008036 tetramer interface [polypeptide binding]; other site 656024008037 argininosuccinate synthase; Provisional; Region: PRK13820 656024008038 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 656024008039 ANP binding site [chemical binding]; other site 656024008040 Substrate Binding Site II [chemical binding]; other site 656024008041 Substrate Binding Site I [chemical binding]; other site 656024008042 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 656024008043 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 656024008044 ornithine carbamoyltransferase; Provisional; Region: PRK00779 656024008045 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 656024008046 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 656024008047 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 656024008048 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 656024008049 inhibitor-cofactor binding pocket; inhibition site 656024008050 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656024008051 catalytic residue [active] 656024008052 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 656024008053 feedback inhibition sensing region; other site 656024008054 homohexameric interface [polypeptide binding]; other site 656024008055 nucleotide binding site [chemical binding]; other site 656024008056 N-acetyl-L-glutamate binding site [chemical binding]; other site 656024008057 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 656024008058 heterotetramer interface [polypeptide binding]; other site 656024008059 active site pocket [active] 656024008060 cleavage site 656024008061 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 656024008062 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 656024008063 FOG: WD40 repeat [General function prediction only]; Region: COG2319 656024008064 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 656024008065 TIGR04222 domain; Region: near_uncomplex 656024008066 hypothetical protein; Provisional; Region: PRK05409 656024008067 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 656024008068 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 656024008069 putative tRNA-binding site [nucleotide binding]; other site 656024008070 B3/4 domain; Region: B3_4; pfam03483 656024008071 tRNA synthetase B5 domain; Region: B5; smart00874 656024008072 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 656024008073 dimer interface [polypeptide binding]; other site 656024008074 motif 1; other site 656024008075 motif 3; other site 656024008076 motif 2; other site 656024008077 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 656024008078 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 656024008079 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 656024008080 dimer interface [polypeptide binding]; other site 656024008081 motif 1; other site 656024008082 active site 656024008083 motif 2; other site 656024008084 motif 3; other site 656024008085 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 656024008086 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656024008087 putative active site [active] 656024008088 heme pocket [chemical binding]; other site 656024008089 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 656024008090 dimer interface [polypeptide binding]; other site 656024008091 phosphorylation site [posttranslational modification] 656024008092 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656024008093 ATP binding site [chemical binding]; other site 656024008094 Mg2+ binding site [ion binding]; other site 656024008095 G-X-G motif; other site 656024008096 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 656024008097 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 656024008098 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 656024008099 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 656024008100 23S rRNA binding site [nucleotide binding]; other site 656024008101 L21 binding site [polypeptide binding]; other site 656024008102 L13 binding site [polypeptide binding]; other site 656024008103 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 656024008104 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 656024008105 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 656024008106 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 656024008107 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 656024008108 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 656024008109 Sulfatase; Region: Sulfatase; pfam00884 656024008110 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 656024008111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024008112 D-galactonate transporter; Region: 2A0114; TIGR00893 656024008113 putative substrate translocation pore; other site 656024008114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024008115 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656024008116 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024008117 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 656024008118 homopentamer interface [polypeptide binding]; other site 656024008119 active site 656024008120 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 656024008121 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 656024008122 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 656024008123 dimerization interface [polypeptide binding]; other site 656024008124 active site 656024008125 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 656024008126 Lumazine binding domain; Region: Lum_binding; pfam00677 656024008127 Lumazine binding domain; Region: Lum_binding; pfam00677 656024008128 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 656024008129 catalytic motif [active] 656024008130 Zn binding site [ion binding]; other site 656024008131 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 656024008132 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 656024008133 substrate binding site [chemical binding]; other site 656024008134 hexamer interface [polypeptide binding]; other site 656024008135 metal binding site [ion binding]; metal-binding site 656024008136 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 656024008137 NusB family; Region: NusB; pfam01029 656024008138 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 656024008139 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 656024008140 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 656024008141 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 656024008142 putative active site [active] 656024008143 substrate binding site [chemical binding]; other site 656024008144 putative cosubstrate binding site; other site 656024008145 catalytic site [active] 656024008146 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 656024008147 substrate binding site [chemical binding]; other site 656024008148 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 656024008149 active site 656024008150 catalytic residues [active] 656024008151 metal binding site [ion binding]; metal-binding site 656024008152 primosome assembly protein PriA; Provisional; Region: PRK14873 656024008153 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 656024008154 S-adenosylmethionine synthetase; Validated; Region: PRK05250 656024008155 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 656024008156 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 656024008157 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 656024008158 Flavoprotein; Region: Flavoprotein; pfam02441 656024008159 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 656024008160 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 656024008161 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 656024008162 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 656024008163 catalytic site [active] 656024008164 G-X2-G-X-G-K; other site 656024008165 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 656024008166 active site 656024008167 dimer interface [polypeptide binding]; other site 656024008168 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 656024008169 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 656024008170 ATP-grasp domain; Region: ATP-grasp_4; cl17255 656024008171 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 656024008172 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 656024008173 ATP-grasp domain; Region: ATP-grasp_4; cl17255 656024008174 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 656024008175 IMP binding site; other site 656024008176 dimer interface [polypeptide binding]; other site 656024008177 interdomain contacts; other site 656024008178 partial ornithine binding site; other site 656024008179 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 656024008180 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 656024008181 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 656024008182 catalytic site [active] 656024008183 subunit interface [polypeptide binding]; other site 656024008184 dihydroorotase; Provisional; Region: PRK04250 656024008185 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 656024008186 active site 656024008187 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 656024008188 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 656024008189 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 656024008190 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 656024008191 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 656024008192 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 656024008193 active site 656024008194 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 656024008195 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 656024008196 non-specific DNA binding site [nucleotide binding]; other site 656024008197 salt bridge; other site 656024008198 sequence-specific DNA binding site [nucleotide binding]; other site 656024008199 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 656024008200 putative RNA binding site [nucleotide binding]; other site 656024008201 elongation factor P; Validated; Region: PRK00529 656024008202 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 656024008203 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 656024008204 RNA binding site [nucleotide binding]; other site 656024008205 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 656024008206 RNA binding site [nucleotide binding]; other site 656024008207 Dehydroquinase class II; Region: DHquinase_II; pfam01220 656024008208 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 656024008209 trimer interface [polypeptide binding]; other site 656024008210 active site 656024008211 dimer interface [polypeptide binding]; other site 656024008212 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 656024008213 active site 656024008214 dimer interface [polypeptide binding]; other site 656024008215 metal binding site [ion binding]; metal-binding site 656024008216 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 656024008217 shikimate kinase; Reviewed; Region: aroK; PRK00131 656024008218 ADP binding site [chemical binding]; other site 656024008219 magnesium binding site [ion binding]; other site 656024008220 putative shikimate binding site; other site 656024008221 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 656024008222 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 656024008223 Tetramer interface [polypeptide binding]; other site 656024008224 active site 656024008225 FMN-binding site [chemical binding]; other site 656024008226 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 656024008227 YceG-like family; Region: YceG; pfam02618 656024008228 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 656024008229 dimerization interface [polypeptide binding]; other site 656024008230 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 656024008231 recombination factor protein RarA; Reviewed; Region: PRK13342 656024008232 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 656024008233 Walker A motif; other site 656024008234 ATP binding site [chemical binding]; other site 656024008235 Walker B motif; other site 656024008236 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 656024008237 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 656024008238 Predicted transcriptional regulators [Transcription]; Region: COG1733 656024008239 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 656024008240 dimerization interface [polypeptide binding]; other site 656024008241 putative DNA binding site [nucleotide binding]; other site 656024008242 putative Zn2+ binding site [ion binding]; other site 656024008243 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 656024008244 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 656024008245 FMN-binding pocket [chemical binding]; other site 656024008246 flavin binding motif; other site 656024008247 phosphate binding motif [ion binding]; other site 656024008248 beta-alpha-beta structure motif; other site 656024008249 NAD binding pocket [chemical binding]; other site 656024008250 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 656024008251 catalytic loop [active] 656024008252 iron binding site [ion binding]; other site 656024008253 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 656024008254 putative active site [active] 656024008255 putative substrate binding site [chemical binding]; other site 656024008256 ATP binding site [chemical binding]; other site 656024008257 Phosphotransferase enzyme family; Region: APH; pfam01636 656024008258 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 656024008259 classical (c) SDRs; Region: SDR_c; cd05233 656024008260 NAD(P) binding site [chemical binding]; other site 656024008261 active site 656024008262 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 656024008263 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 656024008264 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 656024008265 acyl-activating enzyme (AAE) consensus motif; other site 656024008266 putative AMP binding site [chemical binding]; other site 656024008267 putative active site [active] 656024008268 putative CoA binding site [chemical binding]; other site 656024008269 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 656024008270 Cytochrome P450; Region: p450; cl12078 656024008271 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 656024008272 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 656024008273 Tellurite resistance protein TerB; Region: TerB; cl17311 656024008274 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 656024008275 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 656024008276 active site 656024008277 Winged helix-turn helix; Region: HTH_29; pfam13551 656024008278 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024008279 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 656024008280 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 656024008281 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 656024008282 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 656024008283 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 656024008284 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 656024008285 ligand binding site [chemical binding]; other site 656024008286 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 656024008287 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 656024008288 Walker A/P-loop; other site 656024008289 ATP binding site [chemical binding]; other site 656024008290 Q-loop/lid; other site 656024008291 ABC transporter signature motif; other site 656024008292 Walker B; other site 656024008293 D-loop; other site 656024008294 H-loop/switch region; other site 656024008295 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 656024008296 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 656024008297 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 656024008298 TM-ABC transporter signature motif; other site 656024008299 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 656024008300 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 656024008301 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 656024008302 active site 656024008303 PHP Thumb interface [polypeptide binding]; other site 656024008304 metal binding site [ion binding]; metal-binding site 656024008305 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 656024008306 generic binding surface I; other site 656024008307 generic binding surface II; other site 656024008308 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 656024008309 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656024008310 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 656024008311 NAD(P) binding site [chemical binding]; other site 656024008312 active site 656024008313 Archaeal ATPase; Region: Arch_ATPase; pfam01637 656024008314 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 656024008315 Response regulator receiver domain; Region: Response_reg; pfam00072 656024008316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 656024008317 active site 656024008318 phosphorylation site [posttranslational modification] 656024008319 intermolecular recognition site; other site 656024008320 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 656024008321 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 656024008322 active site 656024008323 phosphorylation site [posttranslational modification] 656024008324 intermolecular recognition site; other site 656024008325 dimerization interface [polypeptide binding]; other site 656024008326 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 656024008327 DNA binding residues [nucleotide binding] 656024008328 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656024008329 ATP binding site [chemical binding]; other site 656024008330 Mg2+ binding site [ion binding]; other site 656024008331 G-X-G motif; other site 656024008332 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 656024008333 Sulfatase; Region: Sulfatase; pfam00884 656024008334 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 656024008335 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 656024008336 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 656024008337 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 656024008338 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 656024008339 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656024008340 NAD(P) binding site [chemical binding]; other site 656024008341 active site 656024008342 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 656024008343 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 656024008344 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 656024008345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 656024008346 dimer interface [polypeptide binding]; other site 656024008347 conserved gate region; other site 656024008348 putative PBP binding loops; other site 656024008349 ABC-ATPase subunit interface; other site 656024008350 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 656024008351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 656024008352 dimer interface [polypeptide binding]; other site 656024008353 conserved gate region; other site 656024008354 putative PBP binding loops; other site 656024008355 ABC-ATPase subunit interface; other site 656024008356 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 656024008357 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 656024008358 Walker A/P-loop; other site 656024008359 ATP binding site [chemical binding]; other site 656024008360 Q-loop/lid; other site 656024008361 ABC transporter signature motif; other site 656024008362 Walker B; other site 656024008363 D-loop; other site 656024008364 H-loop/switch region; other site 656024008365 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 656024008366 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 656024008367 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 656024008368 Walker A/P-loop; other site 656024008369 ATP binding site [chemical binding]; other site 656024008370 Q-loop/lid; other site 656024008371 ABC transporter signature motif; other site 656024008372 Walker B; other site 656024008373 D-loop; other site 656024008374 H-loop/switch region; other site 656024008375 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 656024008376 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 656024008377 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 656024008378 putative NAD(P) binding site [chemical binding]; other site 656024008379 Cation efflux family; Region: Cation_efflux; cl00316 656024008380 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 656024008381 putative DNA binding site [nucleotide binding]; other site 656024008382 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 656024008383 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 656024008384 intersubunit interface [polypeptide binding]; other site 656024008385 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 656024008386 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024008387 Walker A/P-loop; other site 656024008388 ATP binding site [chemical binding]; other site 656024008389 Q-loop/lid; other site 656024008390 ABC transporter signature motif; other site 656024008391 Walker B; other site 656024008392 D-loop; other site 656024008393 H-loop/switch region; other site 656024008394 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 656024008395 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 656024008396 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 656024008397 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 656024008398 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024008399 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024008400 DNA-binding interface [nucleotide binding]; DNA binding site 656024008401 putative transposase OrfB; Reviewed; Region: PHA02517 656024008402 HTH-like domain; Region: HTH_21; pfam13276 656024008403 Integrase core domain; Region: rve; pfam00665 656024008404 Integrase core domain; Region: rve_3; pfam13683 656024008405 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 656024008406 putative DNA binding helix; other site 656024008407 metal binding site 2 [ion binding]; metal-binding site 656024008408 metal binding site 1 [ion binding]; metal-binding site 656024008409 structural Zn2+ binding site [ion binding]; other site 656024008410 Transposase, Mutator family; Region: Transposase_mut; pfam00872 656024008411 MULE transposase domain; Region: MULE; pfam10551 656024008412 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 656024008413 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 656024008414 structural tetrad; other site 656024008415 FOG: WD40 repeat [General function prediction only]; Region: COG2319 656024008416 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 656024008417 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 656024008418 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 656024008419 P-loop, Walker A motif; other site 656024008420 Base recognition motif; other site 656024008421 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 656024008422 PemK-like protein; Region: PemK; pfam02452 656024008423 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 656024008424 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 656024008425 active site 656024008426 dimer interface [polypeptide binding]; other site 656024008427 non-prolyl cis peptide bond; other site 656024008428 insertion regions; other site 656024008429 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 656024008430 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 656024008431 active site 656024008432 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 656024008433 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 656024008434 active site 656024008435 Homeodomain-like domain; Region: HTH_23; pfam13384 656024008436 Winged helix-turn helix; Region: HTH_29; pfam13551 656024008437 Homeodomain-like domain; Region: HTH_32; pfam13565 656024008438 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024008439 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 656024008440 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 656024008441 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 656024008442 active site 656024008443 dimer interface [polypeptide binding]; other site 656024008444 non-prolyl cis peptide bond; other site 656024008445 insertion regions; other site 656024008446 Transcriptional regulator [Transcription]; Region: LysR; COG0583 656024008447 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 656024008448 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 656024008449 dimerization interface [polypeptide binding]; other site 656024008450 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 656024008451 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656024008452 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024008453 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 656024008454 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 656024008455 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 656024008456 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 656024008457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 656024008458 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 656024008459 ATP binding site [chemical binding]; other site 656024008460 Mg2+ binding site [ion binding]; other site 656024008461 G-X-G motif; other site 656024008462 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 656024008463 anti sigma factor interaction site; other site 656024008464 regulatory phosphorylation site [posttranslational modification]; other site 656024008465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024008466 putative substrate translocation pore; other site 656024008467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024008468 putative substrate translocation pore; other site 656024008469 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 656024008470 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 656024008471 Probable transposase; Region: OrfB_IS605; pfam01385 656024008472 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 656024008473 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 656024008474 MarR family; Region: MarR; pfam01047 656024008475 TIR domain; Region: TIR_2; pfam13676 656024008476 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 656024008477 Transcriptional regulators [Transcription]; Region: MarR; COG1846 656024008478 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 656024008479 putative DNA binding site [nucleotide binding]; other site 656024008480 putative Zn2+ binding site [ion binding]; other site 656024008481 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024008482 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 656024008483 Walker A/P-loop; other site 656024008484 ATP binding site [chemical binding]; other site 656024008485 Q-loop/lid; other site 656024008486 ABC transporter signature motif; other site 656024008487 Walker B; other site 656024008488 D-loop; other site 656024008489 H-loop/switch region; other site 656024008490 ABC-2 type transporter; Region: ABC2_membrane; cl17235 656024008491 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 656024008492 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 656024008493 Predicted ATPase [General function prediction only]; Region: COG3903 656024008494 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 656024008495 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 656024008496 active site 656024008497 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 656024008498 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 656024008499 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 656024008500 putative active site [active] 656024008501 putative substrate binding site [chemical binding]; other site 656024008502 putative cosubstrate binding site; other site 656024008503 catalytic site [active] 656024008504 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 656024008505 active site 656024008506 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 656024008507 PemK-like protein; Region: PemK; pfam02452 656024008508 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 656024008509 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 656024008510 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 656024008511 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 656024008512 Catalytic domain of Protein Kinases; Region: PKc; cd00180 656024008513 active site 656024008514 ATP binding site [chemical binding]; other site 656024008515 substrate binding site [chemical binding]; other site 656024008516 activation loop (A-loop); other site 656024008517 RDD family; Region: RDD; pfam06271 656024008518 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 656024008519 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 656024008520 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 656024008521 putative active site [active] 656024008522 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 656024008523 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024008524 Walker A/P-loop; other site 656024008525 ATP binding site [chemical binding]; other site 656024008526 Q-loop/lid; other site 656024008527 ABC transporter signature motif; other site 656024008528 Walker B; other site 656024008529 D-loop; other site 656024008530 H-loop/switch region; other site 656024008531 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 656024008532 dimerization interface [polypeptide binding]; other site 656024008533 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 656024008534 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 656024008535 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 656024008536 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 656024008537 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 656024008538 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 656024008539 active site 656024008540 metal binding site [ion binding]; metal-binding site 656024008541 hexamer interface [polypeptide binding]; other site 656024008542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 656024008543 dimer interface [polypeptide binding]; other site 656024008544 conserved gate region; other site 656024008545 ABC-ATPase subunit interface; other site 656024008546 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 656024008547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 656024008548 dimer interface [polypeptide binding]; other site 656024008549 conserved gate region; other site 656024008550 putative PBP binding loops; other site 656024008551 ABC-ATPase subunit interface; other site 656024008552 Helix-turn-helix domain; Region: HTH_20; pfam12840 656024008553 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 656024008554 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 656024008555 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 656024008556 putative active site [active] 656024008557 putative FMN binding site [chemical binding]; other site 656024008558 putative substrate binding site [chemical binding]; other site 656024008559 putative catalytic residue [active] 656024008560 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 656024008561 Signal peptidase subunit; Region: SPC22; cl04601 656024008562 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 656024008563 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 656024008564 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 656024008565 Protein of unknown function DUF72; Region: DUF72; pfam01904 656024008566 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 656024008567 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 656024008568 dimer interface [polypeptide binding]; other site 656024008569 active site 656024008570 heme binding site [chemical binding]; other site 656024008571 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 656024008572 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 656024008573 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024008574 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656024008575 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 656024008576 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 656024008577 NAD binding site [chemical binding]; other site 656024008578 homodimer interface [polypeptide binding]; other site 656024008579 homotetramer interface [polypeptide binding]; other site 656024008580 active site 656024008581 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 656024008582 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 656024008583 dimer interface [polypeptide binding]; other site 656024008584 active site 656024008585 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 656024008586 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 656024008587 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 656024008588 Protein of unknown function (DUF779); Region: DUF779; pfam05610 656024008589 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 656024008590 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 656024008591 NAD(P) binding site [chemical binding]; other site 656024008592 catalytic residues [active] 656024008593 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 656024008594 TIR domain; Region: TIR_2; pfam13676 656024008595 AAA ATPase domain; Region: AAA_16; pfam13191 656024008596 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 656024008597 binding surface 656024008598 TPR motif; other site 656024008599 Tetratricopeptide repeat; Region: TPR_12; pfam13424 656024008600 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 656024008601 binding surface 656024008602 TPR motif; other site 656024008603 Tetratricopeptide repeat; Region: TPR_12; pfam13424 656024008604 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 656024008605 binding surface 656024008606 TPR motif; other site 656024008607 Tetratricopeptide repeat; Region: TPR_12; pfam13424 656024008608 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 656024008609 binding surface 656024008610 TPR motif; other site 656024008611 Tetratricopeptide repeat; Region: TPR_12; pfam13424 656024008612 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 656024008613 binding surface 656024008614 TPR motif; other site 656024008615 Tetratricopeptide repeat; Region: TPR_12; pfam13424 656024008616 Tetratricopeptide repeat; Region: TPR_12; pfam13424 656024008617 Tetratricopeptide repeat; Region: TPR_12; pfam13424 656024008618 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 656024008619 binding surface 656024008620 TPR motif; other site 656024008621 Tetratricopeptide repeat; Region: TPR_12; pfam13424 656024008622 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 656024008623 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024008624 Walker A/P-loop; other site 656024008625 ATP binding site [chemical binding]; other site 656024008626 Q-loop/lid; other site 656024008627 ABC transporter signature motif; other site 656024008628 Walker B; other site 656024008629 D-loop; other site 656024008630 H-loop/switch region; other site 656024008631 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 656024008632 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 656024008633 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024008634 Walker A/P-loop; other site 656024008635 ATP binding site [chemical binding]; other site 656024008636 Q-loop/lid; other site 656024008637 ABC transporter signature motif; other site 656024008638 Walker B; other site 656024008639 D-loop; other site 656024008640 H-loop/switch region; other site 656024008641 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 656024008642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 656024008643 active site 656024008644 phosphorylation site [posttranslational modification] 656024008645 intermolecular recognition site; other site 656024008646 dimerization interface [polypeptide binding]; other site 656024008647 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 656024008648 DNA binding site [nucleotide binding] 656024008649 Putative esterase; Region: Esterase; pfam00756 656024008650 Uncharacterized conserved protein [Function unknown]; Region: COG2898 656024008651 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 656024008652 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 656024008653 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 656024008654 Homeodomain-like domain; Region: HTH_23; pfam13384 656024008655 Winged helix-turn helix; Region: HTH_29; pfam13551 656024008656 Homeodomain-like domain; Region: HTH_32; pfam13565 656024008657 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024008658 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 656024008659 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 656024008660 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 656024008661 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 656024008662 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 656024008663 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 656024008664 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 656024008665 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 656024008666 N-acetyl-D-glucosamine binding site [chemical binding]; other site 656024008667 catalytic residue [active] 656024008668 Protein of unknown function DUF86; Region: DUF86; cl01031 656024008669 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 656024008670 active site 656024008671 NTP binding site [chemical binding]; other site 656024008672 metal binding triad [ion binding]; metal-binding site 656024008673 antibiotic binding site [chemical binding]; other site 656024008674 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 656024008675 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 656024008676 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 656024008677 non-specific DNA binding site [nucleotide binding]; other site 656024008678 salt bridge; other site 656024008679 sequence-specific DNA binding site [nucleotide binding]; other site 656024008680 Pleckstrin homology-like domain; Region: PH-like; cl17171 656024008681 SnoaL-like domain; Region: SnoaL_2; pfam12680 656024008682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024008683 Major Facilitator Superfamily; Region: MFS_1; pfam07690 656024008684 putative substrate translocation pore; other site 656024008685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024008686 Helix-turn-helix domain; Region: HTH_18; pfam12833 656024008687 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 656024008688 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 656024008689 Protein of unknown function DUF86; Region: DUF86; cl01031 656024008690 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 656024008691 metal binding triad [ion binding]; metal-binding site 656024008692 putative transposase OrfB; Reviewed; Region: PHA02517 656024008693 HTH-like domain; Region: HTH_21; pfam13276 656024008694 Integrase core domain; Region: rve; pfam00665 656024008695 Integrase core domain; Region: rve_3; pfam13683 656024008696 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024008697 Transposase; Region: HTH_Tnp_1; pfam01527 656024008698 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 656024008699 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 656024008700 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 656024008701 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 656024008702 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 656024008703 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 656024008704 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 656024008705 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 656024008706 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 656024008707 nudix motif; other site 656024008708 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 656024008709 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 656024008710 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 656024008711 CoenzymeA binding site [chemical binding]; other site 656024008712 subunit interaction site [polypeptide binding]; other site 656024008713 PHB binding site; other site 656024008714 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 656024008715 dimerization interface [polypeptide binding]; other site 656024008716 putative DNA binding site [nucleotide binding]; other site 656024008717 putative Zn2+ binding site [ion binding]; other site 656024008718 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 656024008719 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 656024008720 PBP superfamily domain; Region: PBP_like_2; cl17296 656024008721 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656024008722 PAS domain; Region: PAS_9; pfam13426 656024008723 putative active site [active] 656024008724 PAS fold; Region: PAS_4; pfam08448 656024008725 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656024008726 putative active site [active] 656024008727 heme pocket [chemical binding]; other site 656024008728 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 656024008729 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 656024008730 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 656024008731 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 656024008732 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 656024008733 ATP binding site [chemical binding]; other site 656024008734 putative Mg++ binding site [ion binding]; other site 656024008735 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 656024008736 nucleotide binding region [chemical binding]; other site 656024008737 ATP-binding site [chemical binding]; other site 656024008738 Helicase associated domain (HA2); Region: HA2; pfam04408 656024008739 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 656024008740 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 656024008741 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 656024008742 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 656024008743 active site 656024008744 catalytic tetrad [active] 656024008745 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 656024008746 putative active site [active] 656024008747 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 656024008748 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 656024008749 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 656024008750 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 656024008751 putative active site [active] 656024008752 putative metal binding site [ion binding]; other site 656024008753 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 656024008754 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 656024008755 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 656024008756 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 656024008757 non-specific DNA binding site [nucleotide binding]; other site 656024008758 salt bridge; other site 656024008759 sequence-specific DNA binding site [nucleotide binding]; other site 656024008760 TIGR03085 family protein; Region: TIGR03085 656024008761 RNA binding activity-knot of a chromodomain; Region: Tudor-knot; pfam11717 656024008762 CCC1-related family of proteins; Region: CCC1_like; cl00278 656024008763 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 656024008764 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 656024008765 active site 656024008766 metal binding site [ion binding]; metal-binding site 656024008767 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 656024008768 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 656024008769 active site 656024008770 short chain dehydrogenase; Provisional; Region: PRK07062 656024008771 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656024008772 NAD(P) binding site [chemical binding]; other site 656024008773 active site 656024008774 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 656024008775 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 656024008776 HSP70 interaction site [polypeptide binding]; other site 656024008777 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 656024008778 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 656024008779 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 656024008780 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 656024008781 Sulfate transporter family; Region: Sulfate_transp; pfam00916 656024008782 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 656024008783 active site clefts [active] 656024008784 zinc binding site [ion binding]; other site 656024008785 dimer interface [polypeptide binding]; other site 656024008786 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 656024008787 putative active site [active] 656024008788 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 656024008789 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 656024008790 motif 1; other site 656024008791 active site 656024008792 motif 2; other site 656024008793 motif 3; other site 656024008794 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 656024008795 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 656024008796 Chain length determinant protein; Region: Wzz; cl15801 656024008797 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 656024008798 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 656024008799 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 656024008800 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 656024008801 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 656024008802 NAD(P) binding site [chemical binding]; other site 656024008803 homodimer interface [polypeptide binding]; other site 656024008804 substrate binding site [chemical binding]; other site 656024008805 active site 656024008806 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 656024008807 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 656024008808 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 656024008809 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 656024008810 N-acetyl-D-glucosamine binding site [chemical binding]; other site 656024008811 catalytic residue [active] 656024008812 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 656024008813 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 656024008814 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 656024008815 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 656024008816 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 656024008817 dimer interface [polypeptide binding]; other site 656024008818 active site 656024008819 CoA binding pocket [chemical binding]; other site 656024008820 acyl carrier protein; Provisional; Region: acpP; PRK00982 656024008821 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 656024008822 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 656024008823 dimer interface [polypeptide binding]; other site 656024008824 active site 656024008825 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 656024008826 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 656024008827 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 656024008828 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 656024008829 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 656024008830 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 656024008831 homodimer interface [polypeptide binding]; other site 656024008832 substrate-cofactor binding pocket; other site 656024008833 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656024008834 catalytic residue [active] 656024008835 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 656024008836 Walker A motif; other site 656024008837 ATP binding site [chemical binding]; other site 656024008838 Walker B motif; other site 656024008839 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 656024008840 Peptidase family M41; Region: Peptidase_M41; pfam01434 656024008841 Winged helix-turn helix; Region: HTH_29; pfam13551 656024008842 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024008843 PAS fold; Region: PAS; pfam00989 656024008844 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656024008845 putative active site [active] 656024008846 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 656024008847 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656024008848 metal binding site [ion binding]; metal-binding site 656024008849 active site 656024008850 I-site; other site 656024008851 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 656024008852 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 656024008853 active site 656024008854 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 656024008855 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 656024008856 FeS/SAM binding site; other site 656024008857 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 656024008858 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 656024008859 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 656024008860 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 656024008861 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 656024008862 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 656024008863 putative CoA-transferase; Provisional; Region: PRK11430 656024008864 CoA-transferase family III; Region: CoA_transf_3; pfam02515 656024008865 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 656024008866 proline aminopeptidase P II; Provisional; Region: PRK10879 656024008867 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 656024008868 active site 656024008869 Lsr2; Region: Lsr2; pfam11774 656024008870 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 656024008871 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024008872 Walker A/P-loop; other site 656024008873 ATP binding site [chemical binding]; other site 656024008874 Q-loop/lid; other site 656024008875 ABC transporter signature motif; other site 656024008876 Walker B; other site 656024008877 D-loop; other site 656024008878 H-loop/switch region; other site 656024008879 PAS fold; Region: PAS_4; pfam08448 656024008880 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656024008881 PAS fold; Region: PAS_3; pfam08447 656024008882 putative active site [active] 656024008883 heme pocket [chemical binding]; other site 656024008884 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 656024008885 GAF domain; Region: GAF_3; pfam13492 656024008886 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 656024008887 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 656024008888 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 656024008889 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 656024008890 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 656024008891 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 656024008892 acyl-activating enzyme (AAE) consensus motif; other site 656024008893 AMP binding site [chemical binding]; other site 656024008894 active site 656024008895 CoA binding site [chemical binding]; other site 656024008896 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 656024008897 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 656024008898 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 656024008899 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 656024008900 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 656024008901 DNA binding residues [nucleotide binding] 656024008902 Trehalase; Region: Trehalase; cl17346 656024008903 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 656024008904 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 656024008905 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 656024008906 active site 656024008907 dimer interface [polypeptide binding]; other site 656024008908 effector binding site; other site 656024008909 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 656024008910 TSCPD domain; Region: TSCPD; pfam12637 656024008911 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 656024008912 ATP cone domain; Region: ATP-cone; pfam03477 656024008913 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 656024008914 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 656024008915 LexA repressor; Validated; Region: PRK00215 656024008916 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 656024008917 Catalytic site [active] 656024008918 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 656024008919 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 656024008920 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 656024008921 GTPases [General function prediction only]; Region: HflX; COG2262 656024008922 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 656024008923 HflX GTPase family; Region: HflX; cd01878 656024008924 G1 box; other site 656024008925 GTP/Mg2+ binding site [chemical binding]; other site 656024008926 Switch I region; other site 656024008927 G2 box; other site 656024008928 G3 box; other site 656024008929 Switch II region; other site 656024008930 G4 box; other site 656024008931 G5 box; other site 656024008932 PGAP1-like protein; Region: PGAP1; pfam07819 656024008933 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 656024008934 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 656024008935 active site 656024008936 metal binding site [ion binding]; metal-binding site 656024008937 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 656024008938 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 656024008939 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 656024008940 FeS/SAM binding site; other site 656024008941 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 656024008942 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 656024008943 Zn2+ binding site [ion binding]; other site 656024008944 Mg2+ binding site [ion binding]; other site 656024008945 recombination regulator RecX; Reviewed; Region: recX; PRK00117 656024008946 recombinase A; Provisional; Region: recA; PRK09354 656024008947 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 656024008948 hexamer interface [polypeptide binding]; other site 656024008949 Walker A motif; other site 656024008950 ATP binding site [chemical binding]; other site 656024008951 Walker B motif; other site 656024008952 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 656024008953 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 656024008954 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 656024008955 ATP binding site [chemical binding]; other site 656024008956 putative Mg++ binding site [ion binding]; other site 656024008957 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 656024008958 nucleotide binding region [chemical binding]; other site 656024008959 ATP-binding site [chemical binding]; other site 656024008960 DEAD/H associated; Region: DEAD_assoc; pfam08494 656024008961 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 656024008962 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 656024008963 sequence-specific DNA binding site [nucleotide binding]; other site 656024008964 salt bridge; other site 656024008965 competence damage-inducible protein A; Provisional; Region: PRK00549 656024008966 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 656024008967 putative MPT binding site; other site 656024008968 Competence-damaged protein; Region: CinA; pfam02464 656024008969 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 656024008970 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 656024008971 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 656024008972 Helix-turn-helix domain; Region: HTH_25; pfam13413 656024008973 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 656024008974 Winged helix-turn helix; Region: HTH_29; pfam13551 656024008975 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024008976 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 656024008977 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 656024008978 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 656024008979 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 656024008980 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 656024008981 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 656024008982 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 656024008983 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 656024008984 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 656024008985 dimer interface [polypeptide binding]; other site 656024008986 active site 656024008987 catalytic residue [active] 656024008988 Domain of unknown function (DUF222); Region: DUF222; pfam02720 656024008989 Acetokinase family; Region: Acetate_kinase; cl17229 656024008990 propionate/acetate kinase; Provisional; Region: PRK12379 656024008991 putative phosphoketolase; Provisional; Region: PRK05261 656024008992 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 656024008993 TPP-binding site; other site 656024008994 XFP C-terminal domain; Region: XFP_C; pfam09363 656024008995 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 656024008996 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 656024008997 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 656024008998 nucleotide binding site [chemical binding]; other site 656024008999 putative NEF/HSP70 interaction site [polypeptide binding]; other site 656024009000 SBD interface [polypeptide binding]; other site 656024009001 dihydrodipicolinate reductase; Provisional; Region: PRK00048 656024009002 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 656024009003 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 656024009004 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 656024009005 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 656024009006 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 656024009007 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 656024009008 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 656024009009 RNase E interface [polypeptide binding]; other site 656024009010 trimer interface [polypeptide binding]; other site 656024009011 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 656024009012 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 656024009013 RNase E interface [polypeptide binding]; other site 656024009014 trimer interface [polypeptide binding]; other site 656024009015 active site 656024009016 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 656024009017 putative nucleic acid binding region [nucleotide binding]; other site 656024009018 G-X-X-G motif; other site 656024009019 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 656024009020 RNA binding site [nucleotide binding]; other site 656024009021 domain interface; other site 656024009022 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 656024009023 16S/18S rRNA binding site [nucleotide binding]; other site 656024009024 S13e-L30e interaction site [polypeptide binding]; other site 656024009025 25S rRNA binding site [nucleotide binding]; other site 656024009026 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 656024009027 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 656024009028 active site 656024009029 Riboflavin kinase; Region: Flavokinase; pfam01687 656024009030 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 656024009031 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 656024009032 RNA binding site [nucleotide binding]; other site 656024009033 active site 656024009034 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 656024009035 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 656024009036 DHH family; Region: DHH; pfam01368 656024009037 DHHA1 domain; Region: DHHA1; pfam02272 656024009038 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 656024009039 Protein of unknown function (DUF503); Region: DUF503; pfam04456 656024009040 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 656024009041 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 656024009042 G1 box; other site 656024009043 putative GEF interaction site [polypeptide binding]; other site 656024009044 GTP/Mg2+ binding site [chemical binding]; other site 656024009045 Switch I region; other site 656024009046 G2 box; other site 656024009047 G3 box; other site 656024009048 Switch II region; other site 656024009049 G4 box; other site 656024009050 G5 box; other site 656024009051 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 656024009052 Translation-initiation factor 2; Region: IF-2; pfam11987 656024009053 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 656024009054 Protein of unknown function (DUF448); Region: DUF448; pfam04296 656024009055 putative RNA binding cleft [nucleotide binding]; other site 656024009056 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 656024009057 NusA N-terminal domain; Region: NusA_N; pfam08529 656024009058 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 656024009059 RNA binding site [nucleotide binding]; other site 656024009060 homodimer interface [polypeptide binding]; other site 656024009061 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 656024009062 G-X-X-G motif; other site 656024009063 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 656024009064 G-X-X-G motif; other site 656024009065 ribosome maturation protein RimP; Reviewed; Region: PRK00092 656024009066 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 656024009067 putative oligomer interface [polypeptide binding]; other site 656024009068 putative RNA binding site [nucleotide binding]; other site 656024009069 Predicted transcriptional regulator [Transcription]; Region: COG1959 656024009070 Transcriptional regulator; Region: Rrf2; pfam02082 656024009071 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 656024009072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 656024009073 dimer interface [polypeptide binding]; other site 656024009074 conserved gate region; other site 656024009075 putative PBP binding loops; other site 656024009076 ABC-ATPase subunit interface; other site 656024009077 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 656024009078 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 656024009079 Walker A/P-loop; other site 656024009080 ATP binding site [chemical binding]; other site 656024009081 Q-loop/lid; other site 656024009082 ABC transporter signature motif; other site 656024009083 Walker B; other site 656024009084 D-loop; other site 656024009085 H-loop/switch region; other site 656024009086 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 656024009087 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 656024009088 substrate binding pocket [chemical binding]; other site 656024009089 membrane-bound complex binding site; other site 656024009090 Predicted acetyltransferase [General function prediction only]; Region: COG3393 656024009091 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 656024009092 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 656024009093 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 656024009094 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 656024009095 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 656024009096 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 656024009097 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 656024009098 active site 656024009099 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 656024009100 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 656024009101 putative substrate binding region [chemical binding]; other site 656024009102 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 656024009103 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 656024009104 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 656024009105 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 656024009106 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 656024009107 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 656024009108 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 656024009109 FeS/SAM binding site; other site 656024009110 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 656024009111 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 656024009112 ribosome recycling factor; Reviewed; Region: frr; PRK00083 656024009113 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 656024009114 hinge region; other site 656024009115 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 656024009116 putative nucleotide binding site [chemical binding]; other site 656024009117 uridine monophosphate binding site [chemical binding]; other site 656024009118 homohexameric interface [polypeptide binding]; other site 656024009119 elongation factor Ts; Reviewed; Region: tsf; PRK12332 656024009120 UBA/TS-N domain; Region: UBA; pfam00627 656024009121 Elongation factor TS; Region: EF_TS; pfam00889 656024009122 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 656024009123 rRNA interaction site [nucleotide binding]; other site 656024009124 S8 interaction site; other site 656024009125 putative laminin-1 binding site; other site 656024009126 Peptidase family M23; Region: Peptidase_M23; pfam01551 656024009127 Winged helix-turn helix; Region: HTH_29; pfam13551 656024009128 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024009129 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 656024009130 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 656024009131 active site 656024009132 DNA binding site [nucleotide binding] 656024009133 Int/Topo IB signature motif; other site 656024009134 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 656024009135 DNA protecting protein DprA; Region: dprA; TIGR00732 656024009136 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 656024009137 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 656024009138 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 656024009139 Walker A motif; other site 656024009140 ATP binding site [chemical binding]; other site 656024009141 Walker B motif; other site 656024009142 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 656024009143 hypothetical protein; Reviewed; Region: PRK12497 656024009144 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 656024009145 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 656024009146 RNA/DNA hybrid binding site [nucleotide binding]; other site 656024009147 active site 656024009148 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 656024009149 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 656024009150 Catalytic site [active] 656024009151 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 656024009152 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 656024009153 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 656024009154 RimM N-terminal domain; Region: RimM; pfam01782 656024009155 hypothetical protein; Provisional; Region: PRK02821 656024009156 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 656024009157 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 656024009158 signal recognition particle protein; Provisional; Region: PRK10867 656024009159 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 656024009160 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 656024009161 Signal peptide binding domain; Region: SRP_SPB; pfam02978 656024009162 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 656024009163 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 656024009164 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 656024009165 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 656024009166 Walker A/P-loop; other site 656024009167 ATP binding site [chemical binding]; other site 656024009168 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 656024009169 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024009170 ABC transporter signature motif; other site 656024009171 Walker B; other site 656024009172 D-loop; other site 656024009173 H-loop/switch region; other site 656024009174 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 656024009175 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 656024009176 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 656024009177 DNA binding site [nucleotide binding] 656024009178 catalytic residue [active] 656024009179 H2TH interface [polypeptide binding]; other site 656024009180 putative catalytic residues [active] 656024009181 turnover-facilitating residue; other site 656024009182 intercalation triad [nucleotide binding]; other site 656024009183 8OG recognition residue [nucleotide binding]; other site 656024009184 putative reading head residues; other site 656024009185 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 656024009186 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 656024009187 ribonuclease III; Reviewed; Region: rnc; PRK00102 656024009188 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 656024009189 dimerization interface [polypeptide binding]; other site 656024009190 active site 656024009191 metal binding site [ion binding]; metal-binding site 656024009192 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 656024009193 dsRNA binding site [nucleotide binding]; other site 656024009194 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 656024009195 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 656024009196 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 656024009197 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 656024009198 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 656024009199 ATP binding site [chemical binding]; other site 656024009200 Mg2+ binding site [ion binding]; other site 656024009201 G-X-G motif; other site 656024009202 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 656024009203 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 656024009204 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 656024009205 active site 656024009206 (T/H)XGH motif; other site 656024009207 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 656024009208 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 656024009209 S-adenosylmethionine binding site [chemical binding]; other site 656024009210 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 656024009211 generic binding surface II; other site 656024009212 ssDNA binding site; other site 656024009213 DEAD-like helicases superfamily; Region: DEXDc; smart00487 656024009214 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 656024009215 ATP binding site [chemical binding]; other site 656024009216 putative Mg++ binding site [ion binding]; other site 656024009217 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 656024009218 nucleotide binding region [chemical binding]; other site 656024009219 ATP-binding site [chemical binding]; other site 656024009220 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 656024009221 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 656024009222 dimer interface [polypeptide binding]; other site 656024009223 substrate binding site [chemical binding]; other site 656024009224 ATP binding site [chemical binding]; other site 656024009225 thiamine monophosphate kinase; Provisional; Region: PRK05731 656024009226 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 656024009227 dimerization interface [polypeptide binding]; other site 656024009228 ATP binding site [chemical binding]; other site 656024009229 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 656024009230 AsnC family; Region: AsnC_trans_reg; pfam01037 656024009231 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 656024009232 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 656024009233 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 656024009234 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 656024009235 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 656024009236 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 656024009237 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 656024009238 Guanylyl transferase CofC like; Region: CofC; cl17472 656024009239 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 656024009240 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 656024009241 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 656024009242 polyphosphate kinase; Provisional; Region: PRK05443 656024009243 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 656024009244 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 656024009245 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 656024009246 putative domain interface [polypeptide binding]; other site 656024009247 putative active site [active] 656024009248 catalytic site [active] 656024009249 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 656024009250 putative active site [active] 656024009251 catalytic site [active] 656024009252 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 656024009253 IHF dimer interface [polypeptide binding]; other site 656024009254 IHF - DNA interface [nucleotide binding]; other site 656024009255 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 656024009256 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 656024009257 substrate binding site [chemical binding]; other site 656024009258 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 656024009259 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 656024009260 substrate binding site [chemical binding]; other site 656024009261 ligand binding site [chemical binding]; other site 656024009262 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 656024009263 Transcriptional regulator [Transcription]; Region: IclR; COG1414 656024009264 Bacterial transcriptional regulator; Region: IclR; pfam01614 656024009265 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 656024009266 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 656024009267 ligand binding site [chemical binding]; other site 656024009268 flexible hinge region; other site 656024009269 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 656024009270 non-specific DNA interactions [nucleotide binding]; other site 656024009271 DNA binding site [nucleotide binding] 656024009272 sequence specific DNA binding site [nucleotide binding]; other site 656024009273 putative cAMP binding site [chemical binding]; other site 656024009274 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 656024009275 Catalytic domain of Protein Kinases; Region: PKc; cd00180 656024009276 active site 656024009277 ATP binding site [chemical binding]; other site 656024009278 substrate binding site [chemical binding]; other site 656024009279 activation loop (A-loop); other site 656024009280 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 656024009281 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 656024009282 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 656024009283 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 656024009284 dimer interface [polypeptide binding]; other site 656024009285 phosphorylation site [posttranslational modification] 656024009286 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656024009287 ATP binding site [chemical binding]; other site 656024009288 Mg2+ binding site [ion binding]; other site 656024009289 G-X-G motif; other site 656024009290 Winged helix-turn helix; Region: HTH_29; pfam13551 656024009291 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024009292 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 656024009293 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 656024009294 DNA-binding site [nucleotide binding]; DNA binding site 656024009295 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 656024009296 DNA-binding site [nucleotide binding]; DNA binding site 656024009297 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 656024009298 Zn2+ binding site [ion binding]; other site 656024009299 Mg2+ binding site [ion binding]; other site 656024009300 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 656024009301 nudix motif; other site 656024009302 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 656024009303 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 656024009304 non-specific DNA binding site [nucleotide binding]; other site 656024009305 salt bridge; other site 656024009306 sequence-specific DNA binding site [nucleotide binding]; other site 656024009307 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 656024009308 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 656024009309 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 656024009310 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 656024009311 dimer interface [polypeptide binding]; other site 656024009312 ssDNA binding site [nucleotide binding]; other site 656024009313 tetramer (dimer of dimers) interface [polypeptide binding]; other site 656024009314 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 656024009315 beta-clamp/clamp loader binding surface; other site 656024009316 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 656024009317 nucleotide binding site [chemical binding]; other site 656024009318 polymerase nucleotide-binding site; other site 656024009319 primase nucleotide-binding site [nucleotide binding]; other site 656024009320 DNA-binding residues [nucleotide binding]; DNA binding site 656024009321 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 656024009322 active site 656024009323 catalytic site [active] 656024009324 substrate binding site [chemical binding]; other site 656024009325 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 656024009326 active site 656024009327 DNA binding site [nucleotide binding] 656024009328 catalytic site [active] 656024009329 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 656024009330 Helix-turn-helix domain; Region: HTH_17; pfam12728 656024009331 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 656024009332 active site 656024009333 catalytic residues [active] 656024009334 DNA binding site [nucleotide binding] 656024009335 Int/Topo IB signature motif; other site 656024009336 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 656024009337 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 656024009338 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 656024009339 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 656024009340 Helix-turn-helix domain; Region: HTH_31; pfam13560 656024009341 Phosphotransferase enzyme family; Region: APH; pfam01636 656024009342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 656024009343 S-adenosylmethionine binding site [chemical binding]; other site 656024009344 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 656024009345 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 656024009346 active site 656024009347 catalytic residues [active] 656024009348 metal binding site [ion binding]; metal-binding site 656024009349 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 656024009350 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 656024009351 Peptidase family M48; Region: Peptidase_M48; cl12018 656024009352 Penicillinase repressor; Region: Pencillinase_R; cl17580 656024009353 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 656024009354 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024009355 Walker A/P-loop; other site 656024009356 ATP binding site [chemical binding]; other site 656024009357 Q-loop/lid; other site 656024009358 ABC transporter signature motif; other site 656024009359 Walker B; other site 656024009360 D-loop; other site 656024009361 H-loop/switch region; other site 656024009362 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 656024009363 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 656024009364 Bacitracin resistance protein BacA; Region: BacA; cl00858 656024009365 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 656024009366 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 656024009367 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 656024009368 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 656024009369 ligand binding site [chemical binding]; other site 656024009370 flexible hinge region; other site 656024009371 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 656024009372 putative switch regulator; other site 656024009373 non-specific DNA interactions [nucleotide binding]; other site 656024009374 DNA binding site [nucleotide binding] 656024009375 sequence specific DNA binding site [nucleotide binding]; other site 656024009376 putative cAMP binding site [chemical binding]; other site 656024009377 FOG: CBS domain [General function prediction only]; Region: COG0517 656024009378 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_11; cd04624 656024009379 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 656024009380 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 656024009381 homodimer interface [polypeptide binding]; other site 656024009382 substrate-cofactor binding pocket; other site 656024009383 catalytic residue [active] 656024009384 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 656024009385 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 656024009386 2-isopropylmalate synthase; Validated; Region: PRK03739 656024009387 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 656024009388 active site 656024009389 catalytic residues [active] 656024009390 metal binding site [ion binding]; metal-binding site 656024009391 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 656024009392 Septum formation; Region: Septum_form; pfam13845 656024009393 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 656024009394 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 656024009395 ligand binding site [chemical binding]; other site 656024009396 NAD binding site [chemical binding]; other site 656024009397 dimerization interface [polypeptide binding]; other site 656024009398 catalytic site [active] 656024009399 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 656024009400 putative L-serine binding site [chemical binding]; other site 656024009401 ketol-acid reductoisomerase; Provisional; Region: PRK05479 656024009402 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 656024009403 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 656024009404 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 656024009405 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 656024009406 putative valine binding site [chemical binding]; other site 656024009407 dimer interface [polypeptide binding]; other site 656024009408 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 656024009409 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 656024009410 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 656024009411 PYR/PP interface [polypeptide binding]; other site 656024009412 dimer interface [polypeptide binding]; other site 656024009413 TPP binding site [chemical binding]; other site 656024009414 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 656024009415 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 656024009416 TPP-binding site [chemical binding]; other site 656024009417 dimer interface [polypeptide binding]; other site 656024009418 Transposase, Mutator family; Region: Transposase_mut; pfam00872 656024009419 MULE transposase domain; Region: MULE; pfam10551 656024009420 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 656024009421 oligomeric interface; other site 656024009422 putative active site [active] 656024009423 homodimer interface [polypeptide binding]; other site 656024009424 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 656024009425 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 656024009426 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 656024009427 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 656024009428 GatB domain; Region: GatB_Yqey; smart00845 656024009429 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 656024009430 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 656024009431 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 656024009432 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 656024009433 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 656024009434 active site 656024009435 HIGH motif; other site 656024009436 nucleotide binding site [chemical binding]; other site 656024009437 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 656024009438 active site 656024009439 KMSKS motif; other site 656024009440 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 656024009441 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 656024009442 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 656024009443 nucleotide binding pocket [chemical binding]; other site 656024009444 K-X-D-G motif; other site 656024009445 catalytic site [active] 656024009446 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 656024009447 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 656024009448 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 656024009449 Dimer interface [polypeptide binding]; other site 656024009450 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 656024009451 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 656024009452 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 656024009453 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 656024009454 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 656024009455 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 656024009456 catalytic residue [active] 656024009457 Archaeal ATPase; Region: Arch_ATPase; pfam01637 656024009458 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 656024009459 nudix motif; other site 656024009460 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 656024009461 UTRA domain; Region: UTRA; pfam07702 656024009462 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 656024009463 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 656024009464 MarR family; Region: MarR; pfam01047 656024009465 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 656024009466 B12 binding site [chemical binding]; other site 656024009467 cobalt ligand [ion binding]; other site 656024009468 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 656024009469 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 656024009470 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 656024009471 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 656024009472 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 656024009473 Ligand Binding Site [chemical binding]; other site 656024009474 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 656024009475 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 656024009476 Ligand binding site [chemical binding]; other site 656024009477 Electron transfer flavoprotein domain; Region: ETF; pfam01012 656024009478 Methyltransferase domain; Region: Methyltransf_11; pfam08241 656024009479 Uncharacterized conserved protein [Function unknown]; Region: COG1543 656024009480 N-terminal catalytic domain of heat stable retaining glycoside hydrolase family 57; Region: GH57N_like; cd01022 656024009481 active site 656024009482 catalytic site [active] 656024009483 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 656024009484 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 656024009485 putative catalytic site [active] 656024009486 putative metal binding site [ion binding]; other site 656024009487 putative phosphate binding site [ion binding]; other site 656024009488 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 656024009489 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 656024009490 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 656024009491 trimer interface [polypeptide binding]; other site 656024009492 active site 656024009493 substrate binding site [chemical binding]; other site 656024009494 CoA binding site [chemical binding]; other site 656024009495 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 656024009496 Methyltransferase domain; Region: Methyltransf_31; pfam13847 656024009497 S-adenosylmethionine binding site [chemical binding]; other site 656024009498 enoyl-CoA hydratase; Provisional; Region: PRK05862 656024009499 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 656024009500 substrate binding site [chemical binding]; other site 656024009501 oxyanion hole (OAH) forming residues; other site 656024009502 trimer interface [polypeptide binding]; other site 656024009503 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 656024009504 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 656024009505 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 656024009506 active site 656024009507 catalytic site [active] 656024009508 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 656024009509 Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910 656024009510 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 656024009511 putative homodimer interface [polypeptide binding]; other site 656024009512 putative active site pocket [active] 656024009513 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 656024009514 acetyl-CoA synthetase; Provisional; Region: PRK00174 656024009515 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 656024009516 active site 656024009517 CoA binding site [chemical binding]; other site 656024009518 acyl-activating enzyme (AAE) consensus motif; other site 656024009519 AMP binding site [chemical binding]; other site 656024009520 acetate binding site [chemical binding]; other site 656024009521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024009522 putative substrate translocation pore; other site 656024009523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024009524 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024009525 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 656024009526 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 656024009527 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 656024009528 Double zinc ribbon; Region: DZR; pfam12773 656024009529 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 656024009530 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 656024009531 nucleotide binding site [chemical binding]; other site 656024009532 putative NEF/HSP70 interaction site [polypeptide binding]; other site 656024009533 SBD interface [polypeptide binding]; other site 656024009534 GrpE; Region: GrpE; pfam01025 656024009535 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 656024009536 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 656024009537 putative metal binding site [ion binding]; other site 656024009538 hypothetical protein; Provisional; Region: PRK14013 656024009539 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 656024009540 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 656024009541 putative metal binding site [ion binding]; other site 656024009542 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 656024009543 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 656024009544 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 656024009545 active site 656024009546 homodimer interface [polypeptide binding]; other site 656024009547 catalytic site [active] 656024009548 acceptor binding site [chemical binding]; other site 656024009549 trehalose synthase; Region: treS_nterm; TIGR02456 656024009550 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 656024009551 active site 656024009552 catalytic site [active] 656024009553 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 656024009554 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 656024009555 glycogen branching enzyme; Provisional; Region: PRK05402 656024009556 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 656024009557 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 656024009558 active site 656024009559 catalytic site [active] 656024009560 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 656024009561 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 656024009562 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 656024009563 Domain of unknown function DUF77; Region: DUF77; pfam01910 656024009564 PAS domain; Region: PAS_9; pfam13426 656024009565 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 656024009566 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 656024009567 dimer interface [polypeptide binding]; other site 656024009568 phosphorylation site [posttranslational modification] 656024009569 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656024009570 ATP binding site [chemical binding]; other site 656024009571 Mg2+ binding site [ion binding]; other site 656024009572 G-X-G motif; other site 656024009573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 656024009574 Response regulator receiver domain; Region: Response_reg; pfam00072 656024009575 active site 656024009576 phosphorylation site [posttranslational modification] 656024009577 intermolecular recognition site; other site 656024009578 dimerization interface [polypeptide binding]; other site 656024009579 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 656024009580 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 656024009581 Walker A; other site 656024009582 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 656024009583 Switch II region; other site 656024009584 G4 box; other site 656024009585 G5 box; other site 656024009586 putative acyltransferase; Provisional; Region: PRK05790 656024009587 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 656024009588 dimer interface [polypeptide binding]; other site 656024009589 active site 656024009590 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 656024009591 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 656024009592 dimer interface [polypeptide binding]; other site 656024009593 substrate binding site [chemical binding]; other site 656024009594 metal binding site [ion binding]; metal-binding site 656024009595 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 656024009596 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 656024009597 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 656024009598 DNA binding residues [nucleotide binding] 656024009599 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 656024009600 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 656024009601 NAD(P) binding site [chemical binding]; other site 656024009602 Uncharacterized conserved protein [Function unknown]; Region: COG3339 656024009603 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 656024009604 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 656024009605 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 656024009606 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 656024009607 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 656024009608 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 656024009609 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 656024009610 putative active site [active] 656024009611 hypothetical protein; Provisional; Region: PRK03298 656024009612 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 656024009613 HD domain; Region: HD_4; pfam13328 656024009614 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 656024009615 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 656024009616 B12 binding site [chemical binding]; other site 656024009617 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 656024009618 anti sigma factor interaction site; other site 656024009619 regulatory phosphorylation site [posttranslational modification]; other site 656024009620 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 656024009621 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 656024009622 hinge; other site 656024009623 active site 656024009624 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 656024009625 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 656024009626 gamma subunit interface [polypeptide binding]; other site 656024009627 epsilon subunit interface [polypeptide binding]; other site 656024009628 LBP interface [polypeptide binding]; other site 656024009629 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 656024009630 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 656024009631 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 656024009632 alpha subunit interaction interface [polypeptide binding]; other site 656024009633 Walker A motif; other site 656024009634 ATP binding site [chemical binding]; other site 656024009635 Walker B motif; other site 656024009636 inhibitor binding site; inhibition site 656024009637 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 656024009638 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 656024009639 core domain interface [polypeptide binding]; other site 656024009640 delta subunit interface [polypeptide binding]; other site 656024009641 epsilon subunit interface [polypeptide binding]; other site 656024009642 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 656024009643 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 656024009644 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 656024009645 beta subunit interaction interface [polypeptide binding]; other site 656024009646 Walker A motif; other site 656024009647 ATP binding site [chemical binding]; other site 656024009648 Walker B motif; other site 656024009649 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 656024009650 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 656024009651 ATP synthase CF0 B' subunit; Validated; Region: atpG; CHL00118 656024009652 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 656024009653 ATP synthase subunit C; Region: ATP-synt_C; cl00466 656024009654 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 656024009655 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 656024009656 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 656024009657 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 656024009658 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 656024009659 Mg++ binding site [ion binding]; other site 656024009660 putative catalytic motif [active] 656024009661 substrate binding site [chemical binding]; other site 656024009662 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 656024009663 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 656024009664 dimer interface [polypeptide binding]; other site 656024009665 active site 656024009666 glycine-pyridoxal phosphate binding site [chemical binding]; other site 656024009667 folate binding site [chemical binding]; other site 656024009668 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 656024009669 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 656024009670 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 656024009671 S-adenosylmethionine binding site [chemical binding]; other site 656024009672 peptide chain release factor 1; Validated; Region: prfA; PRK00591 656024009673 This domain is found in peptide chain release factors; Region: PCRF; smart00937 656024009674 RF-1 domain; Region: RF-1; pfam00472 656024009675 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 656024009676 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 656024009677 transcription termination factor Rho; Provisional; Region: PRK12608 656024009678 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 656024009679 RNA binding site [nucleotide binding]; other site 656024009680 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 656024009681 Walker A motif; other site 656024009682 ATP binding site [chemical binding]; other site 656024009683 Walker B motif; other site 656024009684 homoserine kinase; Provisional; Region: PRK01212 656024009685 threonine synthase; Reviewed; Region: PRK06721 656024009686 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 656024009687 homodimer interface [polypeptide binding]; other site 656024009688 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656024009689 catalytic residue [active] 656024009690 homoserine dehydrogenase; Provisional; Region: PRK06349 656024009691 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 656024009692 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 656024009693 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 656024009694 tRNA binding surface [nucleotide binding]; other site 656024009695 DALR anticodon binding domain; Region: DALR_1; smart00836 656024009696 anticodon binding site; other site 656024009697 Response regulator receiver domain; Region: Response_reg; pfam00072 656024009698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 656024009699 active site 656024009700 phosphorylation site [posttranslational modification] 656024009701 intermolecular recognition site; other site 656024009702 dimerization interface [polypeptide binding]; other site 656024009703 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 656024009704 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 656024009705 Walker A/P-loop; other site 656024009706 ATP binding site [chemical binding]; other site 656024009707 Q-loop/lid; other site 656024009708 ABC transporter signature motif; other site 656024009709 Walker B; other site 656024009710 D-loop; other site 656024009711 H-loop/switch region; other site 656024009712 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 656024009713 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 656024009714 EamA-like transporter family; Region: EamA; pfam00892 656024009715 EamA-like transporter family; Region: EamA; pfam00892 656024009716 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 656024009717 Radical SAM superfamily; Region: Radical_SAM; pfam04055 656024009718 FeS/SAM binding site; other site 656024009719 Agmatinase-like family; Region: Agmatinase-like; cd09990 656024009720 agmatinase; Region: agmatinase; TIGR01230 656024009721 active site 656024009722 oligomer interface [polypeptide binding]; other site 656024009723 Mn binding site [ion binding]; other site 656024009724 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 656024009725 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 656024009726 active site 656024009727 catalytic residues [active] 656024009728 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 656024009729 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 656024009730 Homeodomain-like domain; Region: HTH_23; pfam13384 656024009731 Winged helix-turn helix; Region: HTH_29; pfam13551 656024009732 Homeodomain-like domain; Region: HTH_32; pfam13565 656024009733 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024009734 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 656024009735 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 656024009736 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 656024009737 putative metal binding site [ion binding]; other site 656024009738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 656024009739 S-adenosylmethionine binding site [chemical binding]; other site 656024009740 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 656024009741 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 656024009742 PHP-associated; Region: PHP_C; pfam13263 656024009743 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 656024009744 Part of AAA domain; Region: AAA_19; pfam13245 656024009745 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 656024009746 potential frameshift: common BLAST hit: gi|312194713|ref|YP_004014774.1| DNA helicase 656024009747 Part of AAA domain; Region: AAA_19; pfam13245 656024009748 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 656024009749 AAA domain; Region: AAA_12; pfam13087 656024009750 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 656024009751 putative active site [active] 656024009752 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 656024009753 dimer interface [polypeptide binding]; other site 656024009754 putative anticodon binding site; other site 656024009755 tRNA synthetases class II (D, K and N); Region: tRNA-synt_2; pfam00152 656024009756 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 656024009757 motif 1; other site 656024009758 dimer interface [polypeptide binding]; other site 656024009759 active site 656024009760 motif 2; other site 656024009761 motif 3; other site 656024009762 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 656024009763 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 656024009764 Beta-lactamase; Region: Beta-lactamase; pfam00144 656024009765 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 656024009766 malate dehydrogenase; Reviewed; Region: PRK06223 656024009767 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 656024009768 NAD(P) binding site [chemical binding]; other site 656024009769 dimer interface [polypeptide binding]; other site 656024009770 tetramer (dimer of dimers) interface [polypeptide binding]; other site 656024009771 substrate binding site [chemical binding]; other site 656024009772 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 656024009773 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 656024009774 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 656024009775 purine monophosphate binding site [chemical binding]; other site 656024009776 dimer interface [polypeptide binding]; other site 656024009777 putative catalytic residues [active] 656024009778 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 656024009779 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 656024009780 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 656024009781 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 656024009782 active site 656024009783 substrate binding site [chemical binding]; other site 656024009784 cosubstrate binding site; other site 656024009785 catalytic site [active] 656024009786 Helix-turn-helix; Region: HTH_3; pfam01381 656024009787 salt bridge; other site 656024009788 non-specific DNA binding site [nucleotide binding]; other site 656024009789 sequence-specific DNA binding site [nucleotide binding]; other site 656024009790 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 656024009791 CoA binding domain; Region: CoA_binding; smart00881 656024009792 CoA-ligase; Region: Ligase_CoA; pfam00549 656024009793 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 656024009794 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 656024009795 CoA-ligase; Region: Ligase_CoA; pfam00549 656024009796 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 656024009797 B12 binding site [chemical binding]; other site 656024009798 cobalt ligand [ion binding]; other site 656024009799 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 656024009800 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 656024009801 Putative serine esterase (DUF676); Region: DUF676; pfam05057 656024009802 nucleophilic elbow; other site 656024009803 catalytic triad; other site 656024009804 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 656024009805 Peptidase family M23; Region: Peptidase_M23; pfam01551 656024009806 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 656024009807 Part of AAA domain; Region: AAA_19; pfam13245 656024009808 Family description; Region: UvrD_C_2; pfam13538 656024009809 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 656024009810 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 656024009811 tetramer interface [polypeptide binding]; other site 656024009812 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656024009813 catalytic residue [active] 656024009814 GMP synthase; Reviewed; Region: guaA; PRK00074 656024009815 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 656024009816 AMP/PPi binding site [chemical binding]; other site 656024009817 candidate oxyanion hole; other site 656024009818 catalytic triad [active] 656024009819 potential glutamine specificity residues [chemical binding]; other site 656024009820 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 656024009821 ATP Binding subdomain [chemical binding]; other site 656024009822 Ligand Binding sites [chemical binding]; other site 656024009823 Dimerization subdomain; other site 656024009824 Nitrate and nitrite sensing; Region: NIT; pfam08376 656024009825 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 656024009826 HAMP domain; Region: HAMP; pfam00672 656024009827 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656024009828 ATP binding site [chemical binding]; other site 656024009829 Mg2+ binding site [ion binding]; other site 656024009830 G-X-G motif; other site 656024009831 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 656024009832 Protein of unknown function (DUF742); Region: DUF742; pfam05331 656024009833 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 656024009834 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 656024009835 G1 box; other site 656024009836 GTP/Mg2+ binding site [chemical binding]; other site 656024009837 G2 box; other site 656024009838 Switch I region; other site 656024009839 G3 box; other site 656024009840 Switch II region; other site 656024009841 G4 box; other site 656024009842 G5 box; other site 656024009843 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 656024009844 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_4; cd06337 656024009845 putative ligand binding site [chemical binding]; other site 656024009846 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 656024009847 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 656024009848 phosphate binding site [ion binding]; other site 656024009849 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 656024009850 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 656024009851 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 656024009852 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 656024009853 active site 656024009854 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 656024009855 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 656024009856 DNA binding residues [nucleotide binding] 656024009857 B12 binding domain; Region: B12-binding_2; pfam02607 656024009858 Transcription factor WhiB; Region: Whib; pfam02467 656024009859 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 656024009860 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 656024009861 ring oligomerisation interface [polypeptide binding]; other site 656024009862 ATP/Mg binding site [chemical binding]; other site 656024009863 stacking interactions; other site 656024009864 hinge regions; other site 656024009865 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 656024009866 oligomerisation interface [polypeptide binding]; other site 656024009867 mobile loop; other site 656024009868 roof hairpin; other site 656024009869 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 656024009870 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 656024009871 NAD binding site [chemical binding]; other site 656024009872 putative substrate binding site 2 [chemical binding]; other site 656024009873 putative substrate binding site 1 [chemical binding]; other site 656024009874 active site 656024009875 UGMP family protein; Validated; Region: PRK09604 656024009876 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 656024009877 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 656024009878 Coenzyme A binding pocket [chemical binding]; other site 656024009879 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 656024009880 Glycoprotease family; Region: Peptidase_M22; pfam00814 656024009881 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 656024009882 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 656024009883 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 656024009884 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 656024009885 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 656024009886 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 656024009887 alanine racemase; Reviewed; Region: alr; PRK00053 656024009888 active site 656024009889 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 656024009890 dimer interface [polypeptide binding]; other site 656024009891 substrate binding site [chemical binding]; other site 656024009892 catalytic residues [active] 656024009893 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 656024009894 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 656024009895 putative substrate binding site [chemical binding]; other site 656024009896 putative ATP binding site [chemical binding]; other site 656024009897 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 656024009898 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 656024009899 glutaminase active site [active] 656024009900 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 656024009901 dimer interface [polypeptide binding]; other site 656024009902 active site 656024009903 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 656024009904 dimer interface [polypeptide binding]; other site 656024009905 active site 656024009906 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 656024009907 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 656024009908 active site 656024009909 substrate binding site [chemical binding]; other site 656024009910 metal binding site [ion binding]; metal-binding site 656024009911 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 656024009912 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 656024009913 23S rRNA interface [nucleotide binding]; other site 656024009914 L3 interface [polypeptide binding]; other site 656024009915 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 656024009916 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 656024009917 dimerization interface 3.5A [polypeptide binding]; other site 656024009918 active site 656024009919 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 656024009920 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 656024009921 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 656024009922 alphaNTD homodimer interface [polypeptide binding]; other site 656024009923 alphaNTD - beta interaction site [polypeptide binding]; other site 656024009924 alphaNTD - beta' interaction site [polypeptide binding]; other site 656024009925 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 656024009926 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 656024009927 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 656024009928 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 656024009929 RNA binding surface [nucleotide binding]; other site 656024009930 30S ribosomal protein S11; Validated; Region: PRK05309 656024009931 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 656024009932 30S ribosomal protein S13; Region: bact_S13; TIGR03631 656024009933 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 656024009934 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 656024009935 rRNA binding site [nucleotide binding]; other site 656024009936 predicted 30S ribosome binding site; other site 656024009937 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 656024009938 active site 656024009939 adenylate kinase; Reviewed; Region: adk; PRK00279 656024009940 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 656024009941 AMP-binding site [chemical binding]; other site 656024009942 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 656024009943 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 656024009944 SecY translocase; Region: SecY; pfam00344 656024009945 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 656024009946 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 656024009947 23S rRNA binding site [nucleotide binding]; other site 656024009948 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 656024009949 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 656024009950 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 656024009951 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 656024009952 23S rRNA interface [nucleotide binding]; other site 656024009953 L21e interface [polypeptide binding]; other site 656024009954 5S rRNA interface [nucleotide binding]; other site 656024009955 L27 interface [polypeptide binding]; other site 656024009956 L5 interface [polypeptide binding]; other site 656024009957 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 656024009958 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 656024009959 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 656024009960 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 656024009961 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 656024009962 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 656024009963 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 656024009964 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 656024009965 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 656024009966 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 656024009967 RNA binding site [nucleotide binding]; other site 656024009968 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 656024009969 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 656024009970 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 656024009971 putative translocon interaction site; other site 656024009972 23S rRNA interface [nucleotide binding]; other site 656024009973 signal recognition particle (SRP54) interaction site; other site 656024009974 L23 interface [polypeptide binding]; other site 656024009975 trigger factor interaction site; other site 656024009976 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 656024009977 23S rRNA interface [nucleotide binding]; other site 656024009978 5S rRNA interface [nucleotide binding]; other site 656024009979 putative antibiotic binding site [chemical binding]; other site 656024009980 L25 interface [polypeptide binding]; other site 656024009981 L27 interface [polypeptide binding]; other site 656024009982 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 656024009983 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 656024009984 G-X-X-G motif; other site 656024009985 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 656024009986 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 656024009987 protein-rRNA interface [nucleotide binding]; other site 656024009988 putative translocon binding site; other site 656024009989 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 656024009990 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 656024009991 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 656024009992 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 656024009993 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 656024009994 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 656024009995 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 656024009996 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 656024009997 elongation factor Tu; Reviewed; Region: PRK00049 656024009998 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 656024009999 G1 box; other site 656024010000 GEF interaction site [polypeptide binding]; other site 656024010001 GTP/Mg2+ binding site [chemical binding]; other site 656024010002 Switch I region; other site 656024010003 G2 box; other site 656024010004 G3 box; other site 656024010005 Switch II region; other site 656024010006 G4 box; other site 656024010007 G5 box; other site 656024010008 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 656024010009 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 656024010010 Antibiotic Binding Site [chemical binding]; other site 656024010011 elongation factor G; Reviewed; Region: PRK00007 656024010012 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 656024010013 G1 box; other site 656024010014 putative GEF interaction site [polypeptide binding]; other site 656024010015 GTP/Mg2+ binding site [chemical binding]; other site 656024010016 Switch I region; other site 656024010017 G2 box; other site 656024010018 G3 box; other site 656024010019 Switch II region; other site 656024010020 G4 box; other site 656024010021 G5 box; other site 656024010022 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 656024010023 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 656024010024 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 656024010025 30S ribosomal protein S7; Validated; Region: PRK05302 656024010026 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 656024010027 S17 interaction site [polypeptide binding]; other site 656024010028 S8 interaction site; other site 656024010029 16S rRNA interaction site [nucleotide binding]; other site 656024010030 streptomycin interaction site [chemical binding]; other site 656024010031 23S rRNA interaction site [nucleotide binding]; other site 656024010032 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 656024010033 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 656024010034 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 656024010035 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 656024010036 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 656024010037 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024010038 Walker A/P-loop; other site 656024010039 ATP binding site [chemical binding]; other site 656024010040 Q-loop/lid; other site 656024010041 ABC transporter signature motif; other site 656024010042 Walker B; other site 656024010043 D-loop; other site 656024010044 H-loop/switch region; other site 656024010045 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 656024010046 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 656024010047 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 656024010048 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 656024010049 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 656024010050 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 656024010051 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 656024010052 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 656024010053 G-loop; other site 656024010054 DNA binding site [nucleotide binding] 656024010055 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 656024010056 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 656024010057 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 656024010058 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 656024010059 RPB1 interaction site [polypeptide binding]; other site 656024010060 RPB10 interaction site [polypeptide binding]; other site 656024010061 RPB11 interaction site [polypeptide binding]; other site 656024010062 RPB3 interaction site [polypeptide binding]; other site 656024010063 RPB12 interaction site [polypeptide binding]; other site 656024010064 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 656024010065 core dimer interface [polypeptide binding]; other site 656024010066 peripheral dimer interface [polypeptide binding]; other site 656024010067 L10 interface [polypeptide binding]; other site 656024010068 L11 interface [polypeptide binding]; other site 656024010069 putative EF-Tu interaction site [polypeptide binding]; other site 656024010070 putative EF-G interaction site [polypeptide binding]; other site 656024010071 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 656024010072 23S rRNA interface [nucleotide binding]; other site 656024010073 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 656024010074 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 656024010075 mRNA/rRNA interface [nucleotide binding]; other site 656024010076 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 656024010077 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 656024010078 putative thiostrepton binding site; other site 656024010079 23S rRNA interface [nucleotide binding]; other site 656024010080 L7/L12 interface [polypeptide binding]; other site 656024010081 L25 interface [polypeptide binding]; other site 656024010082 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 656024010083 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 656024010084 putative homodimer interface [polypeptide binding]; other site 656024010085 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 656024010086 heterodimer interface [polypeptide binding]; other site 656024010087 homodimer interface [polypeptide binding]; other site 656024010088 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 656024010089 aspartate aminotransferase; Provisional; Region: PRK05764 656024010090 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 656024010091 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656024010092 homodimer interface [polypeptide binding]; other site 656024010093 catalytic residue [active] 656024010094 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 656024010095 active site 2 [active] 656024010096 active site 1 [active] 656024010097 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 656024010098 active site 656024010099 catalytic site [active] 656024010100 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 656024010101 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 656024010102 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 656024010103 active site 656024010104 LGFP repeat; Region: LGFP; pfam08310 656024010105 LGFP repeat; Region: LGFP; pfam08310 656024010106 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 656024010107 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 656024010108 putative active site pocket [active] 656024010109 dimerization interface [polypeptide binding]; other site 656024010110 putative catalytic residue [active] 656024010111 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 656024010112 active site 656024010113 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 656024010114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 656024010115 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 656024010116 heat shock protein HtpX; Provisional; Region: PRK03072 656024010117 Rossmann-like domain; Region: Rossmann-like; pfam10727 656024010118 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 656024010119 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 656024010120 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 656024010121 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 656024010122 dimer interface [polypeptide binding]; other site 656024010123 PYR/PP interface [polypeptide binding]; other site 656024010124 TPP binding site [chemical binding]; other site 656024010125 substrate binding site [chemical binding]; other site 656024010126 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 656024010127 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 656024010128 TPP-binding site [chemical binding]; other site 656024010129 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 656024010130 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 656024010131 substrate binding pocket [chemical binding]; other site 656024010132 chain length determination region; other site 656024010133 substrate-Mg2+ binding site; other site 656024010134 catalytic residues [active] 656024010135 aspartate-rich region 1; other site 656024010136 active site lid residues [active] 656024010137 aspartate-rich region 2; other site 656024010138 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 656024010139 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 656024010140 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 656024010141 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 656024010142 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 656024010143 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 656024010144 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 656024010145 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 656024010146 NADH-ubiquinone/plastoquinone oxidoreductase chain 6; Region: Oxidored_q3; pfam00499 656024010147 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 656024010148 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 656024010149 4Fe-4S binding domain; Region: Fer4; pfam00037 656024010150 4Fe-4S binding domain; Region: Fer4; pfam00037 656024010151 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 656024010152 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 656024010153 NADH dehydrogenase subunit G; Validated; Region: PRK07860 656024010154 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 656024010155 catalytic loop [active] 656024010156 iron binding site [ion binding]; other site 656024010157 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 656024010158 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 656024010159 molybdopterin cofactor binding site; other site 656024010160 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 656024010161 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 656024010162 SLBB domain; Region: SLBB; pfam10531 656024010163 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 656024010164 NADH dehydrogenase subunit E; Validated; Region: PRK07539 656024010165 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 656024010166 putative dimer interface [polypeptide binding]; other site 656024010167 [2Fe-2S] cluster binding site [ion binding]; other site 656024010168 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 656024010169 NADH dehydrogenase subunit D; Validated; Region: PRK06075 656024010170 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 656024010171 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 656024010172 NADH dehydrogenase subunit B; Validated; Region: PRK06411 656024010173 NADH dehydrogenase subunit A; Validated; Region: PRK07928 656024010174 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 656024010175 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 656024010176 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 656024010177 S-adenosylmethionine binding site [chemical binding]; other site 656024010178 adenosine deaminase; Provisional; Region: PRK09358 656024010179 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 656024010180 active site 656024010181 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 656024010182 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 656024010183 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 656024010184 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 656024010185 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 656024010186 putative active site [active] 656024010187 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 656024010188 active site 656024010189 SAM binding site [chemical binding]; other site 656024010190 homodimer interface [polypeptide binding]; other site 656024010191 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 656024010192 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 656024010193 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 656024010194 Active Sites [active] 656024010195 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 656024010196 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 656024010197 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 656024010198 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 656024010199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 656024010200 active site 656024010201 phosphorylation site [posttranslational modification] 656024010202 intermolecular recognition site; other site 656024010203 dimerization interface [polypeptide binding]; other site 656024010204 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 656024010205 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 656024010206 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 656024010207 FeS/SAM binding site; other site 656024010208 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 656024010209 DNA binding residues [nucleotide binding] 656024010210 Flavoprotein; Region: Flavoprotein; pfam02441 656024010211 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 656024010212 prenyltransferase; Reviewed; Region: ubiA; PRK12888 656024010213 UbiA prenyltransferase family; Region: UbiA; pfam01040 656024010214 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 656024010215 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 656024010216 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 656024010217 ResB-like family; Region: ResB; pfam05140 656024010218 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 656024010219 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 656024010220 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 656024010221 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 656024010222 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 656024010223 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 656024010224 catalytic residues [active] 656024010225 Domain of unknown function (DUF222); Region: DUF222; pfam02720 656024010226 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 656024010227 active site 656024010228 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024010229 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024010230 DNA-binding interface [nucleotide binding]; DNA binding site 656024010231 putative transposase OrfB; Reviewed; Region: PHA02517 656024010232 HTH-like domain; Region: HTH_21; pfam13276 656024010233 Integrase core domain; Region: rve; pfam00665 656024010234 Integrase core domain; Region: rve_3; pfam13683 656024010235 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 656024010236 catalytic core [active] 656024010237 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 656024010238 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 656024010239 inhibitor-cofactor binding pocket; inhibition site 656024010240 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656024010241 catalytic residue [active] 656024010242 Predicted transcriptional regulators [Transcription]; Region: COG1695 656024010243 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 656024010244 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024010245 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 656024010246 Walker A/P-loop; other site 656024010247 ATP binding site [chemical binding]; other site 656024010248 Q-loop/lid; other site 656024010249 ABC transporter signature motif; other site 656024010250 Walker B; other site 656024010251 D-loop; other site 656024010252 H-loop/switch region; other site 656024010253 ABC-2 type transporter; Region: ABC2_membrane; cl17235 656024010254 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 656024010255 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 656024010256 dimer interface [polypeptide binding]; other site 656024010257 active site 656024010258 Schiff base residues; other site 656024010259 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 656024010260 homodimer interface [polypeptide binding]; other site 656024010261 active site 656024010262 SAM binding site [chemical binding]; other site 656024010263 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 656024010264 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 656024010265 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 656024010266 active site 656024010267 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 656024010268 Glutamyl-tRNAGlu reductase, N-terminal domain; Region: GlutR_N; pfam05201 656024010269 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 656024010270 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 656024010271 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 656024010272 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 656024010273 CoA binding domain; Region: CoA_binding; smart00881 656024010274 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 656024010275 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 656024010276 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 656024010277 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 656024010278 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 656024010279 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 656024010280 DNA binding residues [nucleotide binding] 656024010281 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 656024010282 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 656024010283 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 656024010284 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 656024010285 putative acyl-acceptor binding pocket; other site 656024010286 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 656024010287 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 656024010288 putative NAD(P) binding site [chemical binding]; other site 656024010289 active site 656024010290 putative substrate binding site [chemical binding]; other site 656024010291 pyrroline-5-carboxylate reductase; Region: PLN02688 656024010292 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 656024010293 Proline dehydrogenase; Region: Pro_dh; cl03282 656024010294 Proline dehydrogenase; Region: Pro_dh; cl03282 656024010295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 656024010296 S-adenosylmethionine binding site [chemical binding]; other site 656024010297 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 656024010298 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 656024010299 exopolyphosphatase; Region: exo_poly_only; TIGR03706 656024010300 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 656024010301 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 656024010302 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 656024010303 active site 656024010304 phosphorylation site [posttranslational modification] 656024010305 intermolecular recognition site; other site 656024010306 dimerization interface [polypeptide binding]; other site 656024010307 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 656024010308 DNA binding site [nucleotide binding] 656024010309 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 656024010310 PAS domain; Region: PAS; smart00091 656024010311 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 656024010312 dimer interface [polypeptide binding]; other site 656024010313 phosphorylation site [posttranslational modification] 656024010314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656024010315 ATP binding site [chemical binding]; other site 656024010316 Mg2+ binding site [ion binding]; other site 656024010317 G-X-G motif; other site 656024010318 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 656024010319 PhoU domain; Region: PhoU; pfam01895 656024010320 PhoU domain; Region: PhoU; pfam01895 656024010321 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 656024010322 catalytic core [active] 656024010323 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 656024010324 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 656024010325 metal binding site 2 [ion binding]; metal-binding site 656024010326 putative DNA binding helix; other site 656024010327 metal binding site 1 [ion binding]; metal-binding site 656024010328 dimer interface [polypeptide binding]; other site 656024010329 structural Zn2+ binding site [ion binding]; other site 656024010330 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 656024010331 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 656024010332 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 656024010333 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 656024010334 binding surface 656024010335 TPR motif; other site 656024010336 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 656024010337 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 656024010338 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 656024010339 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 656024010340 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 656024010341 non-specific DNA binding site [nucleotide binding]; other site 656024010342 salt bridge; other site 656024010343 sequence-specific DNA binding site [nucleotide binding]; other site 656024010344 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 656024010345 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 656024010346 active site 656024010347 catalytic tetrad [active] 656024010348 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 656024010349 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 656024010350 putative ADP-binding pocket [chemical binding]; other site 656024010351 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 656024010352 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 656024010353 heme-binding site [chemical binding]; other site 656024010354 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 656024010355 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 656024010356 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 656024010357 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 656024010358 active site residue [active] 656024010359 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 656024010360 active site residue [active] 656024010361 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 656024010362 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 656024010363 catalytic residues [active] 656024010364 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 656024010365 MoaE interaction surface [polypeptide binding]; other site 656024010366 MoeB interaction surface [polypeptide binding]; other site 656024010367 thiocarboxylated glycine; other site 656024010368 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 656024010369 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 656024010370 DNA binding site [nucleotide binding] 656024010371 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 656024010372 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 656024010373 Coenzyme A binding pocket [chemical binding]; other site 656024010374 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 656024010375 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 656024010376 DNA binding site [nucleotide binding] 656024010377 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 656024010378 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 656024010379 Walker A/P-loop; other site 656024010380 ATP binding site [chemical binding]; other site 656024010381 Q-loop/lid; other site 656024010382 ABC transporter signature motif; other site 656024010383 Walker B; other site 656024010384 D-loop; other site 656024010385 H-loop/switch region; other site 656024010386 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 656024010387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 656024010388 dimer interface [polypeptide binding]; other site 656024010389 conserved gate region; other site 656024010390 putative PBP binding loops; other site 656024010391 ABC-ATPase subunit interface; other site 656024010392 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 656024010393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 656024010394 dimer interface [polypeptide binding]; other site 656024010395 conserved gate region; other site 656024010396 putative PBP binding loops; other site 656024010397 ABC-ATPase subunit interface; other site 656024010398 PBP superfamily domain; Region: PBP_like_2; cl17296 656024010399 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 656024010400 anti sigma factor interaction site; other site 656024010401 regulatory phosphorylation site [posttranslational modification]; other site 656024010402 Frankia-40 domain; Region: Frankia_40_dom; TIGR03917 656024010403 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 656024010404 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 656024010405 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 656024010406 Ferritin-like domain; Region: Ferritin; pfam00210 656024010407 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 656024010408 dimerization interface [polypeptide binding]; other site 656024010409 DPS ferroxidase diiron center [ion binding]; other site 656024010410 ion pore; other site 656024010411 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 656024010412 metal binding site 2 [ion binding]; metal-binding site 656024010413 putative DNA binding helix; other site 656024010414 metal binding site 1 [ion binding]; metal-binding site 656024010415 dimer interface [polypeptide binding]; other site 656024010416 structural Zn2+ binding site [ion binding]; other site 656024010417 Penicillinase repressor; Region: Pencillinase_R; cl17580 656024010418 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 656024010419 putative active site [active] 656024010420 putative metal binding residues [ion binding]; other site 656024010421 signature motif; other site 656024010422 putative triphosphate binding site [ion binding]; other site 656024010423 dimer interface [polypeptide binding]; other site 656024010424 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 656024010425 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 656024010426 CHASE3 domain; Region: CHASE3; cl05000 656024010427 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 656024010428 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 656024010429 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 656024010430 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 656024010431 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 656024010432 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 656024010433 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 656024010434 Histidine kinase; Region: HisKA_3; pfam07730 656024010435 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656024010436 ATP binding site [chemical binding]; other site 656024010437 Mg2+ binding site [ion binding]; other site 656024010438 G-X-G motif; other site 656024010439 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 656024010440 AAA domain; Region: AAA_33; pfam13671 656024010441 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 656024010442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 656024010443 active site 656024010444 phosphorylation site [posttranslational modification] 656024010445 intermolecular recognition site; other site 656024010446 dimerization interface [polypeptide binding]; other site 656024010447 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 656024010448 DNA binding residues [nucleotide binding] 656024010449 dimerization interface [polypeptide binding]; other site 656024010450 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 656024010451 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 656024010452 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 656024010453 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024010454 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024010455 DNA-binding interface [nucleotide binding]; DNA binding site 656024010456 putative transposase OrfB; Reviewed; Region: PHA02517 656024010457 HTH-like domain; Region: HTH_21; pfam13276 656024010458 Integrase core domain; Region: rve; pfam00665 656024010459 Integrase core domain; Region: rve_3; pfam13683 656024010460 histidyl-tRNA synthetase; Region: hisS; TIGR00442 656024010461 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 656024010462 dimer interface [polypeptide binding]; other site 656024010463 motif 1; other site 656024010464 active site 656024010465 motif 2; other site 656024010466 motif 3; other site 656024010467 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 656024010468 anticodon binding site; other site 656024010469 adenylate kinase; Reviewed; Region: adk; PRK00279 656024010470 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 656024010471 AMP-binding site [chemical binding]; other site 656024010472 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 656024010473 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 656024010474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 656024010475 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 656024010476 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 656024010477 active site 656024010478 tetramer interface; other site 656024010479 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 656024010480 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 656024010481 dimer interface [polypeptide binding]; other site 656024010482 putative functional site; other site 656024010483 putative MPT binding site; other site 656024010484 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 656024010485 trimer interface [polypeptide binding]; other site 656024010486 dimer interface [polypeptide binding]; other site 656024010487 putative active site [active] 656024010488 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 656024010489 MPT binding site; other site 656024010490 trimer interface [polypeptide binding]; other site 656024010491 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 656024010492 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 656024010493 Predicted transcriptional regulators [Transcription]; Region: COG1725 656024010494 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 656024010495 DNA-binding site [nucleotide binding]; DNA binding site 656024010496 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 656024010497 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 656024010498 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 656024010499 dimerization interface [polypeptide binding]; other site 656024010500 putative DNA binding site [nucleotide binding]; other site 656024010501 putative Zn2+ binding site [ion binding]; other site 656024010502 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 656024010503 active site 656024010504 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 656024010505 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 656024010506 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 656024010507 Winged helix-turn helix; Region: HTH_33; pfam13592 656024010508 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024010509 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 656024010510 Right handed beta helix region; Region: Beta_helix; pfam13229 656024010511 Homeodomain-like domain; Region: HTH_23; pfam13384 656024010512 Winged helix-turn helix; Region: HTH_29; pfam13551 656024010513 Homeodomain-like domain; Region: HTH_32; pfam13565 656024010514 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024010515 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 656024010516 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 656024010517 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 656024010518 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024010519 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024010520 DNA-binding interface [nucleotide binding]; DNA binding site 656024010521 putative transposase OrfB; Reviewed; Region: PHA02517 656024010522 HTH-like domain; Region: HTH_21; pfam13276 656024010523 Integrase core domain; Region: rve; pfam00665 656024010524 Integrase core domain; Region: rve_3; pfam13683 656024010525 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 656024010526 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 656024010527 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 656024010528 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 656024010529 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 656024010530 oligomeric interface; other site 656024010531 putative active site [active] 656024010532 homodimer interface [polypeptide binding]; other site 656024010533 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 656024010534 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 656024010535 putative active site [active] 656024010536 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 656024010537 Methyltransferase domain; Region: Methyltransf_26; pfam13659 656024010538 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 656024010539 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 656024010540 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 656024010541 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 656024010542 Transposase; Region: DDE_Tnp_ISL3; pfam01610 656024010543 Fic family protein [Function unknown]; Region: COG3177 656024010544 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 656024010545 Methyltransferase domain; Region: Methyltransf_23; pfam13489 656024010546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 656024010547 S-adenosylmethionine binding site [chemical binding]; other site 656024010548 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 656024010549 dimerization interface [polypeptide binding]; other site 656024010550 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 656024010551 dimer interface [polypeptide binding]; other site 656024010552 phosphorylation site [posttranslational modification] 656024010553 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656024010554 ATP binding site [chemical binding]; other site 656024010555 Mg2+ binding site [ion binding]; other site 656024010556 G-X-G motif; other site 656024010557 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 656024010558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 656024010559 active site 656024010560 phosphorylation site [posttranslational modification] 656024010561 intermolecular recognition site; other site 656024010562 dimerization interface [polypeptide binding]; other site 656024010563 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 656024010564 DNA binding site [nucleotide binding] 656024010565 ApbE family; Region: ApbE; pfam02424 656024010566 FMN-binding domain; Region: FMN_bind; cl01081 656024010567 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 656024010568 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 656024010569 FAD binding pocket [chemical binding]; other site 656024010570 FAD binding motif [chemical binding]; other site 656024010571 phosphate binding motif [ion binding]; other site 656024010572 beta-alpha-beta structure motif; other site 656024010573 NAD binding pocket [chemical binding]; other site 656024010574 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 656024010575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 656024010576 S-adenosylmethionine binding site [chemical binding]; other site 656024010577 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 656024010578 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 656024010579 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 656024010580 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656024010581 NAD(P) binding site [chemical binding]; other site 656024010582 active site 656024010583 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 656024010584 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 656024010585 inhibitor-cofactor binding pocket; inhibition site 656024010586 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656024010587 catalytic residue [active] 656024010588 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 656024010589 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 656024010590 PGAP1-like protein; Region: PGAP1; pfam07819 656024010591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024010592 putative substrate translocation pore; other site 656024010593 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 656024010594 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830 656024010595 6-phosphofructokinase; Region: PLN02884 656024010596 active site 656024010597 ADP/pyrophosphate binding site [chemical binding]; other site 656024010598 dimerization interface [polypeptide binding]; other site 656024010599 allosteric effector site; other site 656024010600 fructose-1,6-bisphosphate binding site; other site 656024010601 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 656024010602 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 656024010603 Coenzyme A binding pocket [chemical binding]; other site 656024010604 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 656024010605 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 656024010606 Walker A motif; other site 656024010607 ATP binding site [chemical binding]; other site 656024010608 Walker B motif; other site 656024010609 arginine finger; other site 656024010610 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 656024010611 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 656024010612 Transcription factor WhiB; Region: Whib; pfam02467 656024010613 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 656024010614 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 656024010615 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024010616 Walker A/P-loop; other site 656024010617 ATP binding site [chemical binding]; other site 656024010618 Q-loop/lid; other site 656024010619 ABC transporter signature motif; other site 656024010620 Walker B; other site 656024010621 D-loop; other site 656024010622 H-loop/switch region; other site 656024010623 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 656024010624 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 656024010625 Walker A/P-loop; other site 656024010626 ATP binding site [chemical binding]; other site 656024010627 Q-loop/lid; other site 656024010628 ABC transporter signature motif; other site 656024010629 Walker B; other site 656024010630 D-loop; other site 656024010631 H-loop/switch region; other site 656024010632 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 656024010633 TM-ABC transporter signature motif; other site 656024010634 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 656024010635 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 656024010636 TM-ABC transporter signature motif; other site 656024010637 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 656024010638 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 656024010639 putative ligand binding site [chemical binding]; other site 656024010640 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 656024010641 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 656024010642 ABC-ATPase subunit interface; other site 656024010643 dimer interface [polypeptide binding]; other site 656024010644 putative PBP binding regions; other site 656024010645 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 656024010646 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 656024010647 dimer interface [polypeptide binding]; other site 656024010648 ABC-ATPase subunit interface; other site 656024010649 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 656024010650 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 656024010651 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 656024010652 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 656024010653 intersubunit interface [polypeptide binding]; other site 656024010654 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 656024010655 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 656024010656 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656024010657 NAD(P) binding site [chemical binding]; other site 656024010658 active site 656024010659 Predicted transcriptional regulators [Transcription]; Region: COG1733 656024010660 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 656024010661 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 656024010662 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 656024010663 malonyl-CoA binding site [chemical binding]; other site 656024010664 dimer interface [polypeptide binding]; other site 656024010665 active site 656024010666 product binding site; other site 656024010667 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 656024010668 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 656024010669 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 656024010670 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 656024010671 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 656024010672 DNA-binding interface [nucleotide binding]; DNA binding site 656024010673 putative transposase OrfB; Reviewed; Region: PHA02517 656024010674 HTH-like domain; Region: HTH_21; pfam13276 656024010675 Integrase core domain; Region: rve; pfam00665 656024010676 Integrase core domain; Region: rve_3; pfam13683 656024010677 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 656024010678 Cytochrome P450; Region: p450; cl12078 656024010679 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 656024010680 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 656024010681 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656024010682 PAS domain; Region: PAS_9; pfam13426 656024010683 putative active site [active] 656024010684 heme pocket [chemical binding]; other site 656024010685 PAS fold; Region: PAS_4; pfam08448 656024010686 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 656024010687 GAF domain; Region: GAF_2; pfam13185 656024010688 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 656024010689 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 656024010690 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656024010691 Mg2+ binding site [ion binding]; other site 656024010692 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 656024010693 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 656024010694 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 656024010695 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 656024010696 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 656024010697 active site 656024010698 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656024010699 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024010700 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 656024010701 Catalytic domain of Protein Kinases; Region: PKc; cd00180 656024010702 active site 656024010703 ATP binding site [chemical binding]; other site 656024010704 substrate binding site [chemical binding]; other site 656024010705 activation loop (A-loop); other site 656024010706 Domain of unknown function (DUF427); Region: DUF427; pfam04248 656024010707 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 656024010708 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 656024010709 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 656024010710 Walker A/P-loop; other site 656024010711 ATP binding site [chemical binding]; other site 656024010712 Q-loop/lid; other site 656024010713 ABC transporter signature motif; other site 656024010714 Walker B; other site 656024010715 D-loop; other site 656024010716 H-loop/switch region; other site 656024010717 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 656024010718 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 656024010719 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 656024010720 Walker A/P-loop; other site 656024010721 ATP binding site [chemical binding]; other site 656024010722 Q-loop/lid; other site 656024010723 ABC transporter signature motif; other site 656024010724 Walker B; other site 656024010725 D-loop; other site 656024010726 H-loop/switch region; other site 656024010727 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 656024010728 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 656024010729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 656024010730 dimer interface [polypeptide binding]; other site 656024010731 conserved gate region; other site 656024010732 putative PBP binding loops; other site 656024010733 ABC-ATPase subunit interface; other site 656024010734 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 656024010735 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 656024010736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 656024010737 putative PBP binding loops; other site 656024010738 dimer interface [polypeptide binding]; other site 656024010739 ABC-ATPase subunit interface; other site 656024010740 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 656024010741 active site 656024010742 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 656024010743 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 656024010744 Survival protein SurE; Region: SurE; pfam01975 656024010745 Uncharacterized conserved protein [Function unknown]; Region: COG3391 656024010746 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 656024010747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024010748 D-galactonate transporter; Region: 2A0114; TIGR00893 656024010749 putative substrate translocation pore; other site 656024010750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024010751 Transcriptional regulators [Transcription]; Region: MarR; COG1846 656024010752 Major Facilitator Superfamily; Region: MFS_1; pfam07690 656024010753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024010754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024010755 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656024010756 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024010757 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 656024010758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024010759 putative substrate translocation pore; other site 656024010760 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656024010761 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024010762 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 656024010763 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656024010764 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656024010765 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 656024010766 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656024010767 NAD(P) binding site [chemical binding]; other site 656024010768 active site 656024010769 Homeodomain-like domain; Region: HTH_23; pfam13384 656024010770 Winged helix-turn helix; Region: HTH_29; pfam13551 656024010771 Homeodomain-like domain; Region: HTH_32; pfam13565 656024010772 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024010773 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 656024010774 Phosphoesterase family; Region: Phosphoesterase; pfam04185 656024010775 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 656024010776 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 656024010777 Walker A/P-loop; other site 656024010778 ATP binding site [chemical binding]; other site 656024010779 Q-loop/lid; other site 656024010780 ABC transporter signature motif; other site 656024010781 Walker B; other site 656024010782 D-loop; other site 656024010783 H-loop/switch region; other site 656024010784 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 656024010785 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 656024010786 substrate binding pocket [chemical binding]; other site 656024010787 membrane-bound complex binding site; other site 656024010788 hinge residues; other site 656024010789 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 656024010790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 656024010791 dimer interface [polypeptide binding]; other site 656024010792 conserved gate region; other site 656024010793 putative PBP binding loops; other site 656024010794 ABC-ATPase subunit interface; other site 656024010795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 656024010796 dimer interface [polypeptide binding]; other site 656024010797 conserved gate region; other site 656024010798 putative PBP binding loops; other site 656024010799 ABC-ATPase subunit interface; other site 656024010800 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 656024010801 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 656024010802 active site 656024010803 iron coordination sites [ion binding]; other site 656024010804 MarR family; Region: MarR_2; pfam12802 656024010805 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 656024010806 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 656024010807 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 656024010808 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 656024010809 Walker A/P-loop; other site 656024010810 ATP binding site [chemical binding]; other site 656024010811 Q-loop/lid; other site 656024010812 ABC transporter signature motif; other site 656024010813 Walker B; other site 656024010814 D-loop; other site 656024010815 H-loop/switch region; other site 656024010816 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 656024010817 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 656024010818 FtsX-like permease family; Region: FtsX; pfam02687 656024010819 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 656024010820 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 656024010821 HlyD family secretion protein; Region: HlyD_3; pfam13437 656024010822 Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755 656024010823 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 656024010824 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 656024010825 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 656024010826 putative NAD(P) binding site [chemical binding]; other site 656024010827 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 656024010828 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 656024010829 Cysteine-rich domain; Region: CCG; pfam02754 656024010830 Cysteine-rich domain; Region: CCG; pfam02754 656024010831 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 656024010832 Double zinc ribbon; Region: DZR; pfam12773 656024010833 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 656024010834 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 656024010835 metal ion-dependent adhesion site (MIDAS); other site 656024010836 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 656024010837 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 656024010838 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 656024010839 phosphopeptide binding site; other site 656024010840 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 656024010841 tRNA synthetases class I (C) catalytic domain; Region: tRNA-synt_1e; pfam01406 656024010842 active site 656024010843 HIGH motif; other site 656024010844 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 656024010845 KMSKS motif; other site 656024010846 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 656024010847 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 656024010848 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 656024010849 homotrimer interaction site [polypeptide binding]; other site 656024010850 zinc binding site [ion binding]; other site 656024010851 CDP-binding sites; other site 656024010852 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 656024010853 substrate binding site; other site 656024010854 dimer interface; other site 656024010855 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 656024010856 Protein of unknown function (DUF461); Region: DUF461; cl01071 656024010857 DNA repair protein RadA; Provisional; Region: PRK11823 656024010858 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 656024010859 Walker A motif; other site 656024010860 ATP binding site [chemical binding]; other site 656024010861 Walker B motif; other site 656024010862 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 656024010863 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 656024010864 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 656024010865 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 656024010866 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 656024010867 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 656024010868 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 656024010869 minor groove reading motif; other site 656024010870 helix-hairpin-helix signature motif; other site 656024010871 active site 656024010872 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 656024010873 Frankia-40 domain; Region: Frankia_40_dom; TIGR03917 656024010874 prolyl-tRNA synthetase; Provisional; Region: PRK08661 656024010875 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 656024010876 dimer interface [polypeptide binding]; other site 656024010877 motif 1; other site 656024010878 active site 656024010879 motif 2; other site 656024010880 motif 3; other site 656024010881 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 656024010882 anticodon binding site; other site 656024010883 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 656024010884 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 656024010885 active site 656024010886 ATP binding site [chemical binding]; other site 656024010887 substrate binding site [chemical binding]; other site 656024010888 activation loop (A-loop); other site 656024010889 Ion channel; Region: Ion_trans_2; pfam07885 656024010890 Homeodomain-like domain; Region: HTH_23; pfam13384 656024010891 Winged helix-turn helix; Region: HTH_29; pfam13551 656024010892 Homeodomain-like domain; Region: HTH_32; pfam13565 656024010893 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024010894 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 656024010895 Winged helix-turn helix; Region: HTH_29; pfam13551 656024010896 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024010897 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 656024010898 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 656024010899 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 656024010900 nucleotide binding region [chemical binding]; other site 656024010901 ATP-binding site [chemical binding]; other site 656024010902 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 656024010903 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 656024010904 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 656024010905 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 656024010906 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 656024010907 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 656024010908 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 656024010909 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 656024010910 ATP binding site [chemical binding]; other site 656024010911 Walker A motif; other site 656024010912 hexamer interface [polypeptide binding]; other site 656024010913 Walker B motif; other site 656024010914 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 656024010915 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 656024010916 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 656024010917 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 656024010918 Colicin V production protein; Region: Colicin_V; pfam02674 656024010919 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 656024010920 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 656024010921 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 656024010922 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 656024010923 putative active site [active] 656024010924 putative CoA binding site [chemical binding]; other site 656024010925 nudix motif; other site 656024010926 metal binding site [ion binding]; metal-binding site 656024010927 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 656024010928 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 656024010929 minor groove reading motif; other site 656024010930 helix-hairpin-helix signature motif; other site 656024010931 substrate binding pocket [chemical binding]; other site 656024010932 active site 656024010933 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 656024010934 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 656024010935 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 656024010936 ligand binding site [chemical binding]; other site 656024010937 flexible hinge region; other site 656024010938 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 656024010939 putative switch regulator; other site 656024010940 non-specific DNA interactions [nucleotide binding]; other site 656024010941 DNA binding site [nucleotide binding] 656024010942 sequence specific DNA binding site [nucleotide binding]; other site 656024010943 putative cAMP binding site [chemical binding]; other site 656024010944 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 656024010945 Double zinc ribbon; Region: DZR; pfam12773 656024010946 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 656024010947 cyclase homology domain; Region: CHD; cd07302 656024010948 nucleotidyl binding site; other site 656024010949 metal binding site [ion binding]; metal-binding site 656024010950 dimer interface [polypeptide binding]; other site 656024010951 AAA ATPase domain; Region: AAA_16; pfam13191 656024010952 Tetratricopeptide repeat; Region: TPR_12; pfam13424 656024010953 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 656024010954 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 656024010955 homotrimer interaction site [polypeptide binding]; other site 656024010956 putative active site [active] 656024010957 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 656024010958 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 656024010959 DTAP/Switch II; other site 656024010960 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 656024010961 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 656024010962 P loop; other site 656024010963 Nucleotide binding site [chemical binding]; other site 656024010964 DTAP/Switch II; other site 656024010965 Switch I; other site 656024010966 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 656024010967 Transcription factor WhiB; Region: Whib; pfam02467 656024010968 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 656024010969 Transglycosylase; Region: Transgly; pfam00912 656024010970 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 656024010971 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 656024010972 Yqey-like protein; Region: YqeY; cl17540 656024010973 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 656024010974 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 656024010975 putative active site [active] 656024010976 putative metal binding site [ion binding]; other site 656024010977 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 656024010978 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 656024010979 S-adenosylmethionine binding site [chemical binding]; other site 656024010980 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 656024010981 Winged helix-turn helix; Region: HTH_29; pfam13551 656024010982 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024010983 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 656024010984 anti sigma factor interaction site; other site 656024010985 regulatory phosphorylation site [posttranslational modification]; other site 656024010986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 656024010987 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 656024010988 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 656024010989 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 656024010990 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 656024010991 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 656024010992 active site 656024010993 interdomain interaction site; other site 656024010994 putative metal-binding site [ion binding]; other site 656024010995 nucleotide binding site [chemical binding]; other site 656024010996 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 656024010997 domain I; other site 656024010998 phosphate binding site [ion binding]; other site 656024010999 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 656024011000 domain II; other site 656024011001 domain III; other site 656024011002 nucleotide binding site [chemical binding]; other site 656024011003 DNA binding groove [nucleotide binding] 656024011004 catalytic site [active] 656024011005 domain IV; other site 656024011006 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 656024011007 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 656024011008 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 656024011009 H+ Antiporter protein; Region: 2A0121; TIGR00900 656024011010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656024011011 putative substrate translocation pore; other site 656024011012 thymidylate kinase; Validated; Region: tmk; PRK00698 656024011013 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 656024011014 TMP-binding site; other site 656024011015 ATP-binding site [chemical binding]; other site 656024011016 thymidylate kinase; Provisional; Region: PRK13975; cl17243 656024011017 DNA polymerase III subunit delta'; Validated; Region: PRK07940 656024011018 DNA polymerase III subunit delta'; Validated; Region: PRK08485 656024011019 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 656024011020 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 656024011021 dimer interface [polypeptide binding]; other site 656024011022 active site 656024011023 CoA binding pocket [chemical binding]; other site 656024011024 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 656024011025 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 656024011026 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 656024011027 oligomer interface [polypeptide binding]; other site 656024011028 metal binding site [ion binding]; metal-binding site 656024011029 metal binding site [ion binding]; metal-binding site 656024011030 putative Cl binding site [ion binding]; other site 656024011031 basic sphincter; other site 656024011032 hydrophobic gate; other site 656024011033 periplasmic entrance; other site 656024011034 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 656024011035 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 656024011036 NlpC/P60 family; Region: NLPC_P60; pfam00877 656024011037 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 656024011038 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 656024011039 MarR family; Region: MarR; pfam01047 656024011040 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 656024011041 catalytic triad [active] 656024011042 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 656024011043 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 656024011044 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 656024011045 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 656024011046 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 656024011047 nucleoside/Zn binding site; other site 656024011048 dimer interface [polypeptide binding]; other site 656024011049 catalytic motif [active] 656024011050 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 656024011051 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 656024011052 active site 656024011053 Int/Topo IB signature motif; other site 656024011054 DNA binding site [nucleotide binding] 656024011055 Helix-turn-helix domain; Region: HTH_17; cl17695 656024011056 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 656024011057 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 656024011058 nucleotide binding site [chemical binding]; other site 656024011059 polymerase nucleotide-binding site; other site 656024011060 primase nucleotide-binding site [nucleotide binding]; other site 656024011061 DNA-binding residues [nucleotide binding]; DNA binding site 656024011062 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 656024011063 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 656024011064 dimer interface [polypeptide binding]; other site 656024011065 ssDNA binding site [nucleotide binding]; other site 656024011066 tetramer (dimer of dimers) interface [polypeptide binding]; other site 656024011067 nuclear protein UL24; Provisional; Region: PHA03215 656024011068 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 656024011069 nudix motif; other site 656024011070 chaperone protein DnaJ; Provisional; Region: PRK14277 656024011071 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 656024011072 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 656024011073 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 656024011074 DNA-binding site [nucleotide binding]; DNA binding site 656024011075 UTRA domain; Region: UTRA; cl17743 656024011076 Isochorismatase family; Region: Isochorismatase; pfam00857 656024011077 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 656024011078 catalytic triad [active] 656024011079 conserved cis-peptide bond; other site 656024011080 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 656024011081 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 656024011082 catalytic residue [active] 656024011083 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 656024011084 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 656024011085 GDP-binding site [chemical binding]; other site 656024011086 ACT binding site; other site 656024011087 IMP binding site; other site 656024011088 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 656024011089 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 656024011090 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 656024011091 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 656024011092 AIR carboxylase; Region: AIRC; pfam00731 656024011093 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 656024011094 adenylosuccinate lyase; Region: purB; TIGR00928 656024011095 tetramer interface [polypeptide binding]; other site 656024011096 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 656024011097 ATP binding site [chemical binding]; other site 656024011098 active site 656024011099 substrate binding site [chemical binding]; other site 656024011100 Pantoate-beta-alanine ligase; Region: PanC; cd00560 656024011101 pantoate--beta-alanine ligase; Region: panC; TIGR00018 656024011102 active site 656024011103 ATP-binding site [chemical binding]; other site 656024011104 pantoate-binding site; other site 656024011105 HXXH motif; other site 656024011106 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 656024011107 tetramerization interface [polypeptide binding]; other site 656024011108 active site 656024011109 L-aspartate oxidase; Provisional; Region: PRK07804 656024011110 L-aspartate oxidase; Provisional; Region: PRK06175 656024011111 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 656024011112 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 656024011113 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 656024011114 dimerization interface [polypeptide binding]; other site 656024011115 active site 656024011116 pantothenate kinase; Reviewed; Region: PRK13318 656024011117 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 656024011118 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 656024011119 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 656024011120 DXD motif; other site 656024011121 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 656024011122 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 656024011123 PA14 domain; Region: PA14; cl08459 656024011124 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 656024011125 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 656024011126 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 656024011127 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 656024011128 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 656024011129 Ligand binding site; other site 656024011130 Putative Catalytic site; other site 656024011131 DXD motif; other site 656024011132 Predicted membrane protein [Function unknown]; Region: COG2246 656024011133 GtrA-like protein; Region: GtrA; pfam04138 656024011134 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 656024011135 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 656024011136 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 656024011137 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 656024011138 catalytic residue [active] 656024011139 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 656024011140 Clp protease ATP binding subunit; Region: clpC; CHL00095 656024011141 Clp amino terminal domain; Region: Clp_N; pfam02861 656024011142 Clp amino terminal domain; Region: Clp_N; pfam02861 656024011143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 656024011144 Walker A motif; other site 656024011145 ATP binding site [chemical binding]; other site 656024011146 Walker B motif; other site 656024011147 arginine finger; other site 656024011148 UvrB/uvrC motif; Region: UVR; pfam02151 656024011149 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 656024011150 Walker A motif; other site 656024011151 ATP binding site [chemical binding]; other site 656024011152 Walker B motif; other site 656024011153 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 656024011154 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 656024011155 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 656024011156 active site 656024011157 metal binding site [ion binding]; metal-binding site 656024011158 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 656024011159 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 656024011160 metal ion-dependent adhesion site (MIDAS); other site 656024011161 Winged helix-turn helix; Region: HTH_29; pfam13551 656024011162 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024011163 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 656024011164 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 656024011165 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 656024011166 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 656024011167 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 656024011168 RNHCP domain; Region: RNHCP; pfam12647 656024011169 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 656024011170 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 656024011171 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 656024011172 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 656024011173 Winged helix-turn helix; Region: HTH_29; pfam13551 656024011174 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024011175 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 656024011176 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 656024011177 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 656024011178 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 656024011179 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 656024011180 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 656024011181 active site 656024011182 motif I; other site 656024011183 motif II; other site 656024011184 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 656024011185 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 656024011186 threonine synthase; Validated; Region: PRK07591 656024011187 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 656024011188 homodimer interface [polypeptide binding]; other site 656024011189 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656024011190 catalytic residue [active] 656024011191 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 656024011192 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 656024011193 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 656024011194 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 656024011195 ring oligomerisation interface [polypeptide binding]; other site 656024011196 ATP/Mg binding site [chemical binding]; other site 656024011197 stacking interactions; other site 656024011198 hinge regions; other site 656024011199 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 656024011200 Scramblase; Region: Scramblase; pfam03803 656024011201 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 656024011202 putative active site [active] 656024011203 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 656024011204 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 656024011205 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 656024011206 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 656024011207 ATP binding site [chemical binding]; other site 656024011208 putative Mg++ binding site [ion binding]; other site 656024011209 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 656024011210 nucleotide binding region [chemical binding]; other site 656024011211 ATP-binding site [chemical binding]; other site 656024011212 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 656024011213 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 656024011214 active site 656024011215 Predicted membrane protein [Function unknown]; Region: COG2246 656024011216 GtrA-like protein; Region: GtrA; pfam04138 656024011217 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 656024011218 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 656024011219 protein binding site [polypeptide binding]; other site 656024011220 CopC domain; Region: CopC; pfam04234 656024011221 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 656024011222 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 656024011223 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 656024011224 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 656024011225 MOSC domain; Region: MOSC; pfam03473 656024011226 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 656024011227 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 656024011228 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 656024011229 ligand binding site [chemical binding]; other site 656024011230 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 656024011231 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 656024011232 aminotransferase AlaT; Validated; Region: PRK09265 656024011233 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 656024011234 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656024011235 homodimer interface [polypeptide binding]; other site 656024011236 catalytic residue [active] 656024011237 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 656024011238 metal binding site 2 [ion binding]; metal-binding site 656024011239 putative DNA binding helix; other site 656024011240 metal binding site 1 [ion binding]; metal-binding site 656024011241 dimer interface [polypeptide binding]; other site 656024011242 structural Zn2+ binding site [ion binding]; other site 656024011243 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 656024011244 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 656024011245 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 656024011246 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 656024011247 TPP-binding site [chemical binding]; other site 656024011248 tetramer interface [polypeptide binding]; other site 656024011249 heterodimer interface [polypeptide binding]; other site 656024011250 phosphorylation loop region [posttranslational modification] 656024011251 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 656024011252 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 656024011253 alpha subunit interface [polypeptide binding]; other site 656024011254 TPP binding site [chemical binding]; other site 656024011255 heterodimer interface [polypeptide binding]; other site 656024011256 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 656024011257 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 656024011258 E3 interaction surface; other site 656024011259 lipoyl attachment site [posttranslational modification]; other site 656024011260 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 656024011261 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 656024011262 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 656024011263 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 656024011264 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 656024011265 FAD binding site [chemical binding]; other site 656024011266 substrate binding site [chemical binding]; other site 656024011267 catalytic residues [active] 656024011268 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 656024011269 Double zinc ribbon; Region: DZR; pfam12773 656024011270 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 656024011271 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 656024011272 cyclase homology domain; Region: CHD; cd07302 656024011273 nucleotidyl binding site; other site 656024011274 metal binding site [ion binding]; metal-binding site 656024011275 dimer interface [polypeptide binding]; other site 656024011276 Predicted ATPase [General function prediction only]; Region: COG3899 656024011277 AAA ATPase domain; Region: AAA_16; pfam13191 656024011278 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 656024011279 anti sigma factor interaction site; other site 656024011280 regulatory phosphorylation site [posttranslational modification]; other site 656024011281 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 656024011282 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 656024011283 active site 656024011284 dimer interface [polypeptide binding]; other site 656024011285 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 656024011286 dimer interface [polypeptide binding]; other site 656024011287 active site 656024011288 NHL repeat; Region: NHL; pfam01436 656024011289 NHL repeat; Region: NHL; pfam01436 656024011290 NHL repeat; Region: NHL; pfam01436 656024011291 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 656024011292 Catalytic domain of Protein Kinases; Region: PKc; cd00180 656024011293 active site 656024011294 ATP binding site [chemical binding]; other site 656024011295 substrate binding site [chemical binding]; other site 656024011296 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 656024011297 substrate binding site [chemical binding]; other site 656024011298 activation loop (A-loop); other site 656024011299 activation loop (A-loop); other site 656024011300 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 656024011301 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 656024011302 N-acetyl-D-glucosamine binding site [chemical binding]; other site 656024011303 catalytic residue [active] 656024011304 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 656024011305 NlpC/P60 family; Region: NLPC_P60; pfam00877 656024011306 Helix-turn-helix domain; Region: HTH_17; cl17695 656024011307 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 656024011308 AAA-like domain; Region: AAA_10; pfam12846 656024011309 Catalytic domain of Protein Kinases; Region: PKc; cd00180 656024011310 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 656024011311 active site 656024011312 ATP binding site [chemical binding]; other site 656024011313 substrate binding site [chemical binding]; other site 656024011314 activation loop (A-loop); other site 656024011315 Nuclease-related domain; Region: NERD; pfam08378 656024011316 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 656024011317 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 656024011318 DNA replication factor Dna2; Region: Dna2; pfam08696 656024011319 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 656024011320 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 656024011321 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 656024011322 putative active site [active] 656024011323 putative dimer interface [polypeptide binding]; other site 656024011324 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 656024011325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 656024011326 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 656024011327 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 656024011328 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 656024011329 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 656024011330 non-specific DNA binding site [nucleotide binding]; other site 656024011331 salt bridge; other site 656024011332 sequence-specific DNA binding site [nucleotide binding]; other site 656024011333 Uncharacterized conserved protein [Function unknown]; Region: COG2128 656024011334 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 656024011335 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 656024011336 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 656024011337 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 656024011338 DNA binding residues [nucleotide binding] 656024011339 AAA domain; Region: AAA_14; pfam13173 656024011340 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 656024011341 replicative DNA helicase; Region: DnaB; TIGR00665 656024011342 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 656024011343 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 656024011344 Walker A motif; other site 656024011345 ATP binding site [chemical binding]; other site 656024011346 Walker B motif; other site 656024011347 DNA binding loops [nucleotide binding] 656024011348 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 656024011349 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 656024011350 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 656024011351 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 656024011352 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 656024011353 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 656024011354 dimer interface [polypeptide binding]; other site 656024011355 ssDNA binding site [nucleotide binding]; other site 656024011356 tetramer (dimer of dimers) interface [polypeptide binding]; other site 656024011357 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 656024011358 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 656024011359 active site 656024011360 metal binding site [ion binding]; metal-binding site 656024011361 Winged helix-turn helix; Region: HTH_29; pfam13551 656024011362 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024011363 Predicted integral membrane protein [Function unknown]; Region: COG5650 656024011364 Predicted integral membrane protein [Function unknown]; Region: COG5650 656024011365 Transglycosylase; Region: Transgly; pfam00912 656024011366 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 656024011367 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 656024011368 Predicted transcriptional regulators [Transcription]; Region: COG1695 656024011369 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 656024011370 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 656024011371 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 656024011372 Winged helix-turn helix; Region: HTH_29; pfam13551 656024011373 DDE superfamily endonuclease; Region: DDE_3; pfam13358 656024011374 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 656024011375 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 656024011376 active site 656024011377 NTP binding site [chemical binding]; other site 656024011378 metal binding triad [ion binding]; metal-binding site 656024011379 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 656024011380 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 656024011381 Zn2+ binding site [ion binding]; other site 656024011382 Mg2+ binding site [ion binding]; other site 656024011383 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 656024011384 active site 656024011385 Ap6A binding site [chemical binding]; other site 656024011386 nudix motif; other site 656024011387 metal binding site [ion binding]; metal-binding site 656024011388 integral membrane protein MviN; Region: mviN; TIGR01695 656024011389 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 656024011390 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 656024011391 active site 656024011392 ATP binding site [chemical binding]; other site 656024011393 substrate binding site [chemical binding]; other site 656024011394 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 656024011395 substrate binding site [chemical binding]; other site 656024011396 activation loop (A-loop); other site 656024011397 activation loop (A-loop); other site 656024011398 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 656024011399 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 656024011400 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 656024011401 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 656024011402 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 656024011403 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 656024011404 catalytic residues [active] 656024011405 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 656024011406 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 656024011407 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 656024011408 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 656024011409 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 656024011410 active site 656024011411 metal binding site [ion binding]; metal-binding site 656024011412 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 656024011413 ParB-like nuclease domain; Region: ParBc; pfam02195 656024011414 KorB domain; Region: KorB; pfam08535 656024011415 ParA-like protein; Provisional; Region: PHA02518 656024011416 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 656024011417 Magnesium ion binding site [ion binding]; other site 656024011418 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 656024011419 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 656024011420 uridine kinase; Validated; Region: PRK06696 656024011421 active site 656024011422 gag-polypeptide of LTR copia-type; Region: UBN2; cl15874 656024011423 GAG-pre-integrase domain; Region: gag_pre-integrs; pfam13976 656024011424 Integrase core domain; Region: rve; pfam00665 656024011425 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_2; pfam07727 656024011426 Ty1/Copia family of RNase HI in long-term repeat retroelements; Region: RNase_HI_RT_Ty1; cd09272 656024011427 RNA/DNA hybrid binding site [nucleotide binding]; other site 656024011428 active site 656024011429 AAA-like domain; Region: AAA_10; pfam12846 656024011430 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 656024011431 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 656024011432 dimer interface [polypeptide binding]; other site 656024011433 ssDNA binding site [nucleotide binding]; other site 656024011434 tetramer (dimer of dimers) interface [polypeptide binding]; other site 656024011435 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 656024011436 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 656024011437 P-loop; other site 656024011438 Magnesium ion binding site [ion binding]; other site