-- dump date 20140619_100750 -- class Genbank::misc_feature -- table misc_feature_note -- id note 553190000001 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 553190000002 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 553190000003 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 553190000004 dimerization interface [polypeptide binding]; other site 553190000005 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 553190000006 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 553190000007 catalytic residue [active] 553190000008 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 553190000009 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 553190000010 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 553190000011 peroxiredoxin; Region: AhpC; TIGR03137 553190000012 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 553190000013 decamer (pentamer of dimers) interface [polypeptide binding]; other site 553190000014 catalytic triad [active] 553190000015 dimer interface [polypeptide binding]; other site 553190000016 peroxidatic and resolving cysteines [active] 553190000017 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 553190000018 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 553190000019 nucleophilic elbow; other site 553190000020 catalytic triad; other site 553190000021 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 553190000022 nucleophilic elbow; other site 553190000023 catalytic triad; other site 553190000024 Peptidase family M48; Region: Peptidase_M48; cl12018 553190000025 ferredoxin-NADP+ reductase; Region: PLN02852 553190000026 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 553190000027 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 553190000028 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 553190000029 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 553190000030 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 553190000031 dimerization interface [polypeptide binding]; other site 553190000032 DPS ferroxidase diiron center [ion binding]; other site 553190000033 ion pore; other site 553190000034 Domain of unknown function DUF21; Region: DUF21; pfam01595 553190000035 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 553190000036 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 553190000037 Transporter associated domain; Region: CorC_HlyC; smart01091 553190000038 TIGR03943 family protein; Region: TIGR03943 553190000039 Predicted permease; Region: DUF318; cl17795 553190000040 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 553190000041 active site clefts [active] 553190000042 zinc binding site [ion binding]; other site 553190000043 dimer interface [polypeptide binding]; other site 553190000044 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 553190000045 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 553190000046 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 553190000047 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 553190000048 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 553190000049 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 553190000050 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 553190000051 active site 553190000052 HIGH motif; other site 553190000053 dimer interface [polypeptide binding]; other site 553190000054 KMSKS motif; other site 553190000055 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 553190000056 homodimer interface [polypeptide binding]; other site 553190000057 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 553190000058 active site pocket [active] 553190000059 Rhomboid family; Region: Rhomboid; pfam01694 553190000060 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 553190000061 putative septation inhibitor protein; Reviewed; Region: PRK02251 553190000062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 553190000063 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 553190000064 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 553190000065 active site 553190000066 catalytic site [active] 553190000067 K+-transporting ATPase, c chain; Region: KdpC; cl00944 553190000068 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 553190000069 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 553190000070 active site 553190000071 ATP binding site [chemical binding]; other site 553190000072 substrate binding site [chemical binding]; other site 553190000073 activation loop (A-loop); other site 553190000074 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 553190000075 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 553190000076 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 553190000077 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 553190000078 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 553190000079 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 553190000080 active site 553190000081 ATP binding site [chemical binding]; other site 553190000082 substrate binding site [chemical binding]; other site 553190000083 activation loop (A-loop); other site 553190000084 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 553190000085 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 553190000086 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 553190000087 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 553190000088 active site 553190000089 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 553190000090 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 553190000091 phosphopeptide binding site; other site 553190000092 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 553190000093 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 553190000094 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 553190000095 phosphopeptide binding site; other site 553190000096 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 553190000097 active site 553190000098 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 553190000099 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 553190000100 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 553190000101 DNA gyrase subunit A; Validated; Region: PRK05560 553190000102 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 553190000103 CAP-like domain; other site 553190000104 active site 553190000105 primary dimer interface [polypeptide binding]; other site 553190000106 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 553190000107 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 553190000108 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 553190000109 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 553190000110 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 553190000111 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 553190000112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 553190000113 Mg2+ binding site [ion binding]; other site 553190000114 G-X-G motif; other site 553190000115 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 553190000116 anchoring element; other site 553190000117 dimer interface [polypeptide binding]; other site 553190000118 ATP binding site [chemical binding]; other site 553190000119 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 553190000120 active site 553190000121 putative metal-binding site [ion binding]; other site 553190000122 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 553190000123 Protein of unknown function (DUF721); Region: DUF721; pfam05258 553190000124 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 553190000125 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553190000126 Walker A/P-loop; other site 553190000127 ATP binding site [chemical binding]; other site 553190000128 Q-loop/lid; other site 553190000129 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553190000130 ABC transporter signature motif; other site 553190000131 Walker B; other site 553190000132 D-loop; other site 553190000133 H-loop/switch region; other site 553190000134 DNA polymerase III subunit beta; Validated; Region: PRK07761 553190000135 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 553190000136 putative DNA binding surface [nucleotide binding]; other site 553190000137 dimer interface [polypeptide binding]; other site 553190000138 beta-clamp/clamp loader binding surface; other site 553190000139 beta-clamp/translesion DNA polymerase binding surface; other site 553190000140 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 553190000141 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 553190000142 Walker A motif; other site 553190000143 ATP binding site [chemical binding]; other site 553190000144 Walker B motif; other site 553190000145 arginine finger; other site 553190000146 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 553190000147 DnaA box-binding interface [nucleotide binding]; other site 553190000148 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 553190000149 Ribonuclease P; Region: Ribonuclease_P; pfam00825 553190000150 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 553190000151 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 553190000152 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 553190000153 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 553190000154 G-X-X-G motif; other site 553190000155 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 553190000156 RxxxH motif; other site 553190000157 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 553190000158 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 553190000159 S-adenosylmethionine binding site [chemical binding]; other site 553190000160 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 553190000161 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 553190000162 P-loop; other site 553190000163 Magnesium ion binding site [ion binding]; other site 553190000164 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 553190000165 Magnesium ion binding site [ion binding]; other site 553190000166 ParB-like nuclease domain; Region: ParB; smart00470 553190000167 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 553190000168 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 553190000169 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 553190000170 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 553190000171 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 553190000172 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 553190000173 active site 553190000174 Ap6A binding site [chemical binding]; other site 553190000175 nudix motif; other site 553190000176 metal binding site [ion binding]; metal-binding site 553190000177 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 553190000178 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 553190000179 active site 553190000180 NTP binding site [chemical binding]; other site 553190000181 metal binding triad [ion binding]; metal-binding site 553190000182 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 553190000183 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 553190000184 Zn2+ binding site [ion binding]; other site 553190000185 Mg2+ binding site [ion binding]; other site 553190000186 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 553190000187 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 553190000188 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 553190000189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 553190000190 G5 domain; Region: G5; pfam07501 553190000191 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 553190000192 N-acetyl-D-glucosamine binding site [chemical binding]; other site 553190000193 catalytic residue [active] 553190000194 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 553190000195 Catalytic domain of Protein Kinases; Region: PKc; cd00180 553190000196 active site 553190000197 ATP binding site [chemical binding]; other site 553190000198 substrate binding site [chemical binding]; other site 553190000199 activation loop (A-loop); other site 553190000200 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 553190000201 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 553190000202 catalytic residues [active] 553190000203 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 553190000204 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 553190000205 catalytic residues [active] 553190000206 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 553190000207 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 553190000208 Walker A/P-loop; other site 553190000209 ATP binding site [chemical binding]; other site 553190000210 Q-loop/lid; other site 553190000211 ABC transporter signature motif; other site 553190000212 Walker B; other site 553190000213 D-loop; other site 553190000214 H-loop/switch region; other site 553190000215 TOBE domain; Region: TOBE_2; pfam08402 553190000216 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 553190000217 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 553190000218 catalytic residues [active] 553190000219 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 553190000220 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 553190000221 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 553190000222 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 553190000223 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 553190000224 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 553190000225 putative efflux protein, MATE family; Region: matE; TIGR00797 553190000226 replicative DNA helicase; Region: DnaB; TIGR00665 553190000227 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 553190000228 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 553190000229 Walker A motif; other site 553190000230 ATP binding site [chemical binding]; other site 553190000231 Walker B motif; other site 553190000232 DNA binding loops [nucleotide binding] 553190000233 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 553190000234 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 553190000235 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 553190000236 catalytic triad [active] 553190000237 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 553190000238 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 553190000239 active site 553190000240 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 553190000241 active site 553190000242 Ap6A binding site [chemical binding]; other site 553190000243 nudix motif; other site 553190000244 metal binding site [ion binding]; metal-binding site 553190000245 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 553190000246 catalytic core [active] 553190000247 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 553190000248 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 553190000249 cofactor binding site; other site 553190000250 DNA binding site [nucleotide binding] 553190000251 substrate interaction site [chemical binding]; other site 553190000252 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 553190000253 putative active site [active] 553190000254 polyphosphate kinase; Provisional; Region: PRK05443 553190000255 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 553190000256 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 553190000257 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 553190000258 putative domain interface [polypeptide binding]; other site 553190000259 putative active site [active] 553190000260 catalytic site [active] 553190000261 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 553190000262 putative domain interface [polypeptide binding]; other site 553190000263 putative active site [active] 553190000264 catalytic site [active] 553190000265 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 553190000266 amphipathic channel; other site 553190000267 Asn-Pro-Ala signature motifs; other site 553190000268 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 553190000269 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 553190000270 active site 553190000271 HIGH motif; other site 553190000272 nucleotide binding site [chemical binding]; other site 553190000273 active site 553190000274 KMSKS motif; other site 553190000275 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 553190000276 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 553190000277 catalytic residue [active] 553190000278 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 553190000279 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 553190000280 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 553190000281 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 553190000282 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 553190000283 Clp amino terminal domain; Region: Clp_N; pfam02861 553190000284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 553190000285 Walker A motif; other site 553190000286 ATP binding site [chemical binding]; other site 553190000287 Walker B motif; other site 553190000288 arginine finger; other site 553190000289 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 553190000290 Walker A motif; other site 553190000291 ATP binding site [chemical binding]; other site 553190000292 Walker B motif; other site 553190000293 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 553190000294 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553190000295 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 553190000296 Walker A/P-loop; other site 553190000297 ATP binding site [chemical binding]; other site 553190000298 Q-loop/lid; other site 553190000299 ABC transporter signature motif; other site 553190000300 Walker B; other site 553190000301 D-loop; other site 553190000302 H-loop/switch region; other site 553190000303 RmuC family; Region: RmuC; pfam02646 553190000304 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 553190000305 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 553190000306 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 553190000307 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553190000308 Walker A/P-loop; other site 553190000309 ATP binding site [chemical binding]; other site 553190000310 Q-loop/lid; other site 553190000311 ABC transporter signature motif; other site 553190000312 Walker B; other site 553190000313 D-loop; other site 553190000314 H-loop/switch region; other site 553190000315 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 553190000316 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 553190000317 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 553190000318 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 553190000319 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 553190000320 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 553190000321 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 553190000322 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 553190000323 GatB domain; Region: GatB_Yqey; pfam02637 553190000324 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 553190000325 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 553190000326 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 553190000327 hypothetical protein; Provisional; Region: PRK07208 553190000328 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 553190000329 UDP-galactopyranose mutase; Region: GLF; pfam03275 553190000330 transcription termination factor Rho; Provisional; Region: PRK12678 553190000331 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 553190000332 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 553190000333 RNA binding site [nucleotide binding]; other site 553190000334 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 553190000335 Walker A motif; other site 553190000336 ATP binding site [chemical binding]; other site 553190000337 Walker B motif; other site 553190000338 aspartate aminotransferase; Provisional; Region: PRK05764 553190000339 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 553190000340 pyridoxal 5'-phosphate binding site [chemical binding]; other site 553190000341 homodimer interface [polypeptide binding]; other site 553190000342 catalytic residue [active] 553190000343 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 553190000344 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 553190000345 putative DNA binding site [nucleotide binding]; other site 553190000346 putative Zn2+ binding site [ion binding]; other site 553190000347 AsnC family; Region: AsnC_trans_reg; pfam01037 553190000348 Chorismate mutase type II; Region: CM_2; cl00693 553190000349 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 553190000350 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 553190000351 active site 553190000352 intersubunit interface [polypeptide binding]; other site 553190000353 zinc binding site [ion binding]; other site 553190000354 Na+ binding site [ion binding]; other site 553190000355 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 553190000356 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 553190000357 GDP-binding site [chemical binding]; other site 553190000358 ACT binding site; other site 553190000359 IMP binding site; other site 553190000360 CrcB-like protein; Region: CRCB; pfam02537 553190000361 CrcB-like protein; Region: CRCB; pfam02537 553190000362 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 553190000363 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 553190000364 Cl- selectivity filter; other site 553190000365 Cl- binding residues [ion binding]; other site 553190000366 pore gating glutamate residue; other site 553190000367 dimer interface [polypeptide binding]; other site 553190000368 H+/Cl- coupling transport residue; other site 553190000369 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 553190000370 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 553190000371 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 553190000372 Walker A motif; other site 553190000373 ATP binding site [chemical binding]; other site 553190000374 Walker B motif; other site 553190000375 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 553190000376 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 553190000377 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 553190000378 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 553190000379 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 553190000380 Walker A motif; other site 553190000381 ATP binding site [chemical binding]; other site 553190000382 Walker B motif; other site 553190000383 arginine finger; other site 553190000384 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 553190000385 recombination protein RecR; Reviewed; Region: recR; PRK00076 553190000386 RecR protein; Region: RecR; pfam02132 553190000387 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 553190000388 putative active site [active] 553190000389 putative metal-binding site [ion binding]; other site 553190000390 tetramer interface [polypeptide binding]; other site 553190000391 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 553190000392 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 553190000393 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 553190000394 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 553190000395 Walker A/P-loop; other site 553190000396 ATP binding site [chemical binding]; other site 553190000397 Q-loop/lid; other site 553190000398 ABC transporter signature motif; other site 553190000399 Walker B; other site 553190000400 D-loop; other site 553190000401 H-loop/switch region; other site 553190000402 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 553190000403 FtsX-like permease family; Region: FtsX; pfam02687 553190000404 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 553190000405 FtsX-like permease family; Region: FtsX; pfam02687 553190000406 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 553190000407 hypothetical protein; Provisional; Region: PRK03298 553190000408 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 553190000409 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 553190000410 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 553190000411 homoserine O-succinyltransferase; Provisional; Region: PRK05368 553190000412 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 553190000413 proposed active site lysine [active] 553190000414 conserved cys residue [active] 553190000415 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 553190000416 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 553190000417 ATP synthase subunit C; Region: ATP-synt_C; cl00466 553190000418 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 553190000419 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 553190000420 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 553190000421 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 553190000422 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 553190000423 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 553190000424 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 553190000425 beta subunit interaction interface [polypeptide binding]; other site 553190000426 Walker A motif; other site 553190000427 ATP binding site [chemical binding]; other site 553190000428 Walker B motif; other site 553190000429 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 553190000430 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 553190000431 core domain interface [polypeptide binding]; other site 553190000432 delta subunit interface [polypeptide binding]; other site 553190000433 epsilon subunit interface [polypeptide binding]; other site 553190000434 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 553190000435 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 553190000436 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 553190000437 alpha subunit interaction interface [polypeptide binding]; other site 553190000438 Walker A motif; other site 553190000439 ATP binding site [chemical binding]; other site 553190000440 Walker B motif; other site 553190000441 inhibitor binding site; inhibition site 553190000442 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 553190000443 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cl10033 553190000444 LBP interface [polypeptide binding]; other site 553190000445 gamma subunit interface [polypeptide binding]; other site 553190000446 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 553190000447 FIC domain binding interface [polypeptide binding]; other site 553190000448 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 553190000449 Fic/DOC family; Region: Fic; cl00960 553190000450 Fic family protein [Function unknown]; Region: COG3177 553190000451 Fic/DOC family; Region: Fic; pfam02661 553190000452 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 553190000453 ApbE family; Region: ApbE; pfam02424 553190000454 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 553190000455 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 553190000456 dimer interface [polypeptide binding]; other site 553190000457 phosphorylation site [posttranslational modification] 553190000458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 553190000459 ATP binding site [chemical binding]; other site 553190000460 Mg2+ binding site [ion binding]; other site 553190000461 G-X-G motif; other site 553190000462 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 553190000463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 553190000464 active site 553190000465 phosphorylation site [posttranslational modification] 553190000466 intermolecular recognition site; other site 553190000467 dimerization interface [polypeptide binding]; other site 553190000468 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 553190000469 DNA binding site [nucleotide binding] 553190000470 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 553190000471 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 553190000472 Walker A/P-loop; other site 553190000473 ATP binding site [chemical binding]; other site 553190000474 Q-loop/lid; other site 553190000475 ABC transporter signature motif; other site 553190000476 Walker B; other site 553190000477 D-loop; other site 553190000478 H-loop/switch region; other site 553190000479 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 553190000480 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 553190000481 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 553190000482 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 553190000483 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 553190000484 Iron permease FTR1 family; Region: FTR1; cl00475 553190000485 Fe2+ transport protein; Region: Iron_transport; pfam10634 553190000486 Predicted membrane protein [Function unknown]; Region: COG4393 553190000487 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 553190000488 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 553190000489 FtsX-like permease family; Region: FtsX; pfam02687 553190000490 FtsX-like permease family; Region: FtsX; pfam02687 553190000491 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 553190000492 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 553190000493 Walker A/P-loop; other site 553190000494 ATP binding site [chemical binding]; other site 553190000495 Q-loop/lid; other site 553190000496 ABC transporter signature motif; other site 553190000497 Walker B; other site 553190000498 D-loop; other site 553190000499 H-loop/switch region; other site 553190000500 FMN-binding domain; Region: FMN_bind; pfam04205 553190000501 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 553190000502 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 553190000503 active site 553190000504 phosphorylation site [posttranslational modification] 553190000505 intermolecular recognition site; other site 553190000506 dimerization interface [polypeptide binding]; other site 553190000507 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 553190000508 DNA binding residues [nucleotide binding] 553190000509 dimerization interface [polypeptide binding]; other site 553190000510 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 553190000511 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 553190000512 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 553190000513 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 553190000514 dimer interface [polypeptide binding]; other site 553190000515 putative radical transfer pathway; other site 553190000516 diiron center [ion binding]; other site 553190000517 tyrosyl radical; other site 553190000518 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 553190000519 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 553190000520 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 553190000521 Class I ribonucleotide reductase; Region: RNR_I; cd01679 553190000522 active site 553190000523 dimer interface [polypeptide binding]; other site 553190000524 catalytic residues [active] 553190000525 effector binding site; other site 553190000526 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 553190000527 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 553190000528 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 553190000529 catalytic residues [active] 553190000530 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 553190000531 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 553190000532 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 553190000533 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 553190000534 Walker A motif; other site 553190000535 ATP binding site [chemical binding]; other site 553190000536 Walker B motif; other site 553190000537 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 553190000538 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 553190000539 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 553190000540 putative active site [active] 553190000541 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 553190000542 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 553190000543 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 553190000544 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 553190000545 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 553190000546 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 553190000547 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 553190000548 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 553190000549 catalytic triad [active] 553190000550 catalytic triad [active] 553190000551 oxyanion hole [active] 553190000552 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 553190000553 dimer interface [polypeptide binding]; other site 553190000554 substrate binding site [chemical binding]; other site 553190000555 metal binding sites [ion binding]; metal-binding site 553190000556 oligosaccharyl transferase, archaeosortase A system-associated; Region: archaeo_STT3; TIGR04154 553190000557 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 553190000558 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 553190000559 DNA binding site [nucleotide binding] 553190000560 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 553190000561 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 553190000562 minor groove reading motif; other site 553190000563 helix-hairpin-helix signature motif; other site 553190000564 substrate binding pocket [chemical binding]; other site 553190000565 active site 553190000566 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 553190000567 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 553190000568 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 553190000569 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 553190000570 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 553190000571 active site 553190000572 HIGH motif; other site 553190000573 nucleotide binding site [chemical binding]; other site 553190000574 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 553190000575 active site 553190000576 KMSKS motif; other site 553190000577 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 553190000578 tRNA binding surface [nucleotide binding]; other site 553190000579 anticodon binding site; other site 553190000580 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 553190000581 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 553190000582 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 553190000583 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 553190000584 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 553190000585 active site 553190000586 HIGH motif; other site 553190000587 KMSK motif region; other site 553190000588 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 553190000589 tRNA binding surface [nucleotide binding]; other site 553190000590 anticodon binding site; other site 553190000591 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 553190000592 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 553190000593 GtrA-like protein; Region: GtrA; pfam04138 553190000594 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 553190000595 catalytic core [active] 553190000596 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 553190000597 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 553190000598 HIGH motif; other site 553190000599 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 553190000600 active site 553190000601 KMSKS motif; other site 553190000602 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 553190000603 active site 553190000604 metal binding site [ion binding]; metal-binding site 553190000605 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 553190000606 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 553190000607 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 553190000608 hinge; other site 553190000609 active site 553190000610 Catalytic domain of Protein Kinases; Region: PKc; cd00180 553190000611 active site 553190000612 ATP binding site [chemical binding]; other site 553190000613 substrate binding site [chemical binding]; other site 553190000614 activation loop (A-loop); other site 553190000615 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 553190000616 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 553190000617 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 553190000618 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 553190000619 16S/18S rRNA binding site [nucleotide binding]; other site 553190000620 S13e-L30e interaction site [polypeptide binding]; other site 553190000621 25S rRNA binding site [nucleotide binding]; other site 553190000622 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 553190000623 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 553190000624 oligomer interface [polypeptide binding]; other site 553190000625 RNA binding site [nucleotide binding]; other site 553190000626 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 553190000627 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 553190000628 RNase E interface [polypeptide binding]; other site 553190000629 trimer interface [polypeptide binding]; other site 553190000630 active site 553190000631 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 553190000632 putative nucleic acid binding region [nucleotide binding]; other site 553190000633 G-X-X-G motif; other site 553190000634 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 553190000635 RNA binding site [nucleotide binding]; other site 553190000636 domain interface; other site 553190000637 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 553190000638 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 553190000639 active site 553190000640 catalytic tetrad [active] 553190000641 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 553190000642 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 553190000643 DivIVA protein; Region: DivIVA; pfam05103 553190000644 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 553190000645 trimer interface [polypeptide binding]; other site 553190000646 active site 553190000647 G bulge; other site 553190000648 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 553190000649 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 553190000650 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 553190000651 PBP superfamily domain; Region: PBP_like_2; cl17296 553190000652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553190000653 dimer interface [polypeptide binding]; other site 553190000654 conserved gate region; other site 553190000655 putative PBP binding loops; other site 553190000656 ABC-ATPase subunit interface; other site 553190000657 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 553190000658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553190000659 dimer interface [polypeptide binding]; other site 553190000660 conserved gate region; other site 553190000661 putative PBP binding loops; other site 553190000662 ABC-ATPase subunit interface; other site 553190000663 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 553190000664 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 553190000665 Walker A/P-loop; other site 553190000666 ATP binding site [chemical binding]; other site 553190000667 Q-loop/lid; other site 553190000668 ABC transporter signature motif; other site 553190000669 Walker B; other site 553190000670 D-loop; other site 553190000671 H-loop/switch region; other site 553190000672 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 553190000673 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 553190000674 23S rRNA interface [nucleotide binding]; other site 553190000675 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 553190000676 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 553190000677 core dimer interface [polypeptide binding]; other site 553190000678 peripheral dimer interface [polypeptide binding]; other site 553190000679 L10 interface [polypeptide binding]; other site 553190000680 L11 interface [polypeptide binding]; other site 553190000681 putative EF-Tu interaction site [polypeptide binding]; other site 553190000682 putative EF-G interaction site [polypeptide binding]; other site 553190000683 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 553190000684 phosphopeptide binding site; other site 553190000685 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 553190000686 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 553190000687 oligomerisation interface [polypeptide binding]; other site 553190000688 mobile loop; other site 553190000689 roof hairpin; other site 553190000690 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 553190000691 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 553190000692 pyridoxal 5'-phosphate binding site [chemical binding]; other site 553190000693 homodimer interface [polypeptide binding]; other site 553190000694 catalytic residue [active] 553190000695 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 553190000696 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 553190000697 FAD binding domain; Region: FAD_binding_4; pfam01565 553190000698 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 553190000699 amino acid transporter; Region: 2A0306; TIGR00909 553190000700 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 553190000701 Ferredoxin [Energy production and conversion]; Region: COG1146 553190000702 4Fe-4S binding domain; Region: Fer4; pfam00037 553190000703 DNA polymerase IV; Validated; Region: PRK02406 553190000704 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 553190000705 active site 553190000706 DNA binding site [nucleotide binding] 553190000707 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 553190000708 F0F1 ATP synthase subunit alpha; Validated; Region: PRK07165 553190000709 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 553190000710 putative homodimer interface [polypeptide binding]; other site 553190000711 putative homotetramer interface [polypeptide binding]; other site 553190000712 putative allosteric switch controlling residues; other site 553190000713 putative metal binding site [ion binding]; other site 553190000714 putative homodimer-homodimer interface [polypeptide binding]; other site 553190000715 Uncharacterized conserved protein [Function unknown]; Region: COG1739 553190000716 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 553190000717 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 553190000718 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 553190000719 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 553190000720 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 553190000721 23S rRNA interface [nucleotide binding]; other site 553190000722 L3 interface [polypeptide binding]; other site 553190000723 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 553190000724 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 553190000725 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 553190000726 putative catalytic cysteine [active] 553190000727 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 553190000728 putative active site [active] 553190000729 metal binding site [ion binding]; metal-binding site 553190000730 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 553190000731 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 553190000732 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 553190000733 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 553190000734 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 553190000735 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 553190000736 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 553190000737 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 553190000738 putative translocon binding site; other site 553190000739 protein-rRNA interface [nucleotide binding]; other site 553190000740 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 553190000741 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 553190000742 G-X-X-G motif; other site 553190000743 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 553190000744 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 553190000745 23S rRNA interface [nucleotide binding]; other site 553190000746 5S rRNA interface [nucleotide binding]; other site 553190000747 putative antibiotic binding site [chemical binding]; other site 553190000748 L25 interface [polypeptide binding]; other site 553190000749 L27 interface [polypeptide binding]; other site 553190000750 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 553190000751 23S rRNA interface [nucleotide binding]; other site 553190000752 putative translocon interaction site; other site 553190000753 signal recognition particle (SRP54) interaction site; other site 553190000754 L23 interface [polypeptide binding]; other site 553190000755 trigger factor interaction site; other site 553190000756 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 553190000757 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 553190000758 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 553190000759 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 553190000760 RNA binding site [nucleotide binding]; other site 553190000761 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 553190000762 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 553190000763 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 553190000764 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 553190000765 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 553190000766 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 553190000767 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 553190000768 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 553190000769 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 553190000770 5S rRNA interface [nucleotide binding]; other site 553190000771 23S rRNA interface [nucleotide binding]; other site 553190000772 L5 interface [polypeptide binding]; other site 553190000773 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 553190000774 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 553190000775 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 553190000776 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 553190000777 23S rRNA binding site [nucleotide binding]; other site 553190000778 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 553190000779 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 553190000780 SecY translocase; Region: SecY; pfam00344 553190000781 adenylate kinase; Reviewed; Region: adk; PRK00279 553190000782 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 553190000783 AMP-binding site [chemical binding]; other site 553190000784 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 553190000785 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 553190000786 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 553190000787 30S ribosomal protein S13; Region: bact_S13; TIGR03631 553190000788 30S ribosomal protein S11; Validated; Region: PRK05309 553190000789 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 553190000790 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 553190000791 alphaNTD homodimer interface [polypeptide binding]; other site 553190000792 alphaNTD - beta interaction site [polypeptide binding]; other site 553190000793 alphaNTD - beta' interaction site [polypeptide binding]; other site 553190000794 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 553190000795 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 553190000796 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 553190000797 nucleophilic elbow; other site 553190000798 catalytic triad; other site 553190000799 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 553190000800 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 553190000801 dimerization interface 3.5A [polypeptide binding]; other site 553190000802 active site 553190000803 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 553190000804 NusA N-terminal domain; Region: NusA_N; pfam08529 553190000805 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 553190000806 RNA binding site [nucleotide binding]; other site 553190000807 homodimer interface [polypeptide binding]; other site 553190000808 NusA-like KH domain; Region: KH_5; pfam13184 553190000809 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 553190000810 G-X-X-G motif; other site 553190000811 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 553190000812 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 553190000813 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 553190000814 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 553190000815 G1 box; other site 553190000816 putative GEF interaction site [polypeptide binding]; other site 553190000817 GTP/Mg2+ binding site [chemical binding]; other site 553190000818 Switch I region; other site 553190000819 G2 box; other site 553190000820 G3 box; other site 553190000821 Switch II region; other site 553190000822 G4 box; other site 553190000823 G5 box; other site 553190000824 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 553190000825 Translation-initiation factor 2; Region: IF-2; pfam11987 553190000826 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 553190000827 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 553190000828 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 553190000829 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 553190000830 RNA binding site [nucleotide binding]; other site 553190000831 active site 553190000832 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 553190000833 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 553190000834 active site 553190000835 Riboflavin kinase; Region: Flavokinase; smart00904 553190000836 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 553190000837 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 553190000838 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 553190000839 substrate binding site [chemical binding]; other site 553190000840 ATP binding site [chemical binding]; other site 553190000841 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 553190000842 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 553190000843 Isochorismatase family; Region: Isochorismatase; pfam00857 553190000844 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 553190000845 catalytic triad [active] 553190000846 conserved cis-peptide bond; other site 553190000847 DNA repair protein RadA; Provisional; Region: PRK11823 553190000848 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 553190000849 Walker A motif; other site 553190000850 ATP binding site [chemical binding]; other site 553190000851 Walker B motif; other site 553190000852 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 553190000853 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 553190000854 tetramer (dimer of dimers) interface [polypeptide binding]; other site 553190000855 active site 553190000856 dimer interface [polypeptide binding]; other site 553190000857 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 553190000858 RNA/DNA hybrid binding site [nucleotide binding]; other site 553190000859 active site 553190000860 phosphoglucomutase; Validated; Region: PRK07564 553190000861 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 553190000862 active site 553190000863 substrate binding site [chemical binding]; other site 553190000864 metal binding site [ion binding]; metal-binding site 553190000865 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 553190000866 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 553190000867 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 553190000868 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 553190000869 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 553190000870 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 553190000871 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 553190000872 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 553190000873 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 553190000874 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 553190000875 ligand binding site [chemical binding]; other site 553190000876 flexible hinge region; other site 553190000877 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 553190000878 putative switch regulator; other site 553190000879 non-specific DNA interactions [nucleotide binding]; other site 553190000880 DNA binding site [nucleotide binding] 553190000881 sequence specific DNA binding site [nucleotide binding]; other site 553190000882 putative cAMP binding site [chemical binding]; other site 553190000883 Transglycosylase; Region: Transgly; pfam00912 553190000884 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 553190000885 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 553190000886 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 553190000887 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 553190000888 quinone interaction residues [chemical binding]; other site 553190000889 active site 553190000890 catalytic residues [active] 553190000891 FMN binding site [chemical binding]; other site 553190000892 substrate binding site [chemical binding]; other site 553190000893 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 553190000894 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 553190000895 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 553190000896 dimer interface [polypeptide binding]; other site 553190000897 ssDNA binding site [nucleotide binding]; other site 553190000898 tetramer (dimer of dimers) interface [polypeptide binding]; other site 553190000899 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 553190000900 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 553190000901 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 553190000902 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 553190000903 mevalonate kinase; Region: mevalon_kin; TIGR00549 553190000904 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 553190000905 diphosphomevalonate decarboxylase; Region: PLN02407 553190000906 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 553190000907 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 553190000908 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 553190000909 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 553190000910 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 553190000911 homotetramer interface [polypeptide binding]; other site 553190000912 FMN binding site [chemical binding]; other site 553190000913 homodimer contacts [polypeptide binding]; other site 553190000914 putative active site [active] 553190000915 putative substrate binding site [chemical binding]; other site 553190000916 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 553190000917 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 553190000918 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 553190000919 ATP binding site [chemical binding]; other site 553190000920 putative Mg++ binding site [ion binding]; other site 553190000921 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 553190000922 nucleotide binding region [chemical binding]; other site 553190000923 ATP-binding site [chemical binding]; other site 553190000924 putative kinase; Provisional; Region: PRK09954 553190000925 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 553190000926 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 553190000927 substrate binding site [chemical binding]; other site 553190000928 ATP binding site [chemical binding]; other site 553190000929 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 553190000930 active site 553190000931 tetramer interface [polypeptide binding]; other site 553190000932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553190000933 Major Facilitator Superfamily; Region: MFS_1; pfam07690 553190000934 putative substrate translocation pore; other site 553190000935 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 553190000936 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 553190000937 S-adenosylmethionine binding site [chemical binding]; other site 553190000938 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 553190000939 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 553190000940 RimM N-terminal domain; Region: RimM; pfam01782 553190000941 hypothetical protein; Provisional; Region: PRK02821 553190000942 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 553190000943 G-X-X-G motif; other site 553190000944 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 553190000945 signal recognition particle protein; Provisional; Region: PRK10867 553190000946 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 553190000947 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 553190000948 P loop; other site 553190000949 GTP binding site [chemical binding]; other site 553190000950 Signal peptide binding domain; Region: SRP_SPB; pfam02978 553190000951 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 553190000952 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 553190000953 active site 553190000954 HIGH motif; other site 553190000955 nucleotide binding site [chemical binding]; other site 553190000956 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 553190000957 KMSKS motif; other site 553190000958 tRNA binding surface [nucleotide binding]; other site 553190000959 anticodon binding site; other site 553190000960 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 553190000961 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 553190000962 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 553190000963 active site 553190000964 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 553190000965 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 553190000966 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 553190000967 active site 553190000968 (T/H)XGH motif; other site 553190000969 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 553190000970 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 553190000971 ribonuclease III; Reviewed; Region: rnc; PRK00102 553190000972 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 553190000973 dimerization interface [polypeptide binding]; other site 553190000974 active site 553190000975 metal binding site [ion binding]; metal-binding site 553190000976 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 553190000977 dsRNA binding site [nucleotide binding]; other site 553190000978 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 553190000979 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 553190000980 ABC transporter; Region: ABC_tran_2; pfam12848 553190000981 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 553190000982 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 553190000983 ribonuclease PH; Reviewed; Region: rph; PRK00173 553190000984 Ribonuclease PH; Region: RNase_PH_bact; cd11362 553190000985 hexamer interface [polypeptide binding]; other site 553190000986 active site 553190000987 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 553190000988 active site 553190000989 dimerization interface [polypeptide binding]; other site 553190000990 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 553190000991 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 553190000992 active site 553190000993 dimer interface [polypeptide binding]; other site 553190000994 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 553190000995 dimer interface [polypeptide binding]; other site 553190000996 active site 553190000997 ykoK leader 553190000998 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 553190000999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553190001000 dimer interface [polypeptide binding]; other site 553190001001 conserved gate region; other site 553190001002 putative PBP binding loops; other site 553190001003 ABC-ATPase subunit interface; other site 553190001004 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 553190001005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553190001006 dimer interface [polypeptide binding]; other site 553190001007 conserved gate region; other site 553190001008 putative PBP binding loops; other site 553190001009 ABC-ATPase subunit interface; other site 553190001010 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 553190001011 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 553190001012 Walker A/P-loop; other site 553190001013 ATP binding site [chemical binding]; other site 553190001014 Q-loop/lid; other site 553190001015 ABC transporter signature motif; other site 553190001016 Walker B; other site 553190001017 D-loop; other site 553190001018 H-loop/switch region; other site 553190001019 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 553190001020 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 553190001021 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 553190001022 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 553190001023 Catalytic site [active] 553190001024 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 553190001025 RNA/DNA hybrid binding site [nucleotide binding]; other site 553190001026 active site 553190001027 Transcriptional regulators [Transcription]; Region: PurR; COG1609 553190001028 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 553190001029 DNA binding site [nucleotide binding] 553190001030 domain linker motif; other site 553190001031 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 553190001032 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553190001033 Q-loop/lid; other site 553190001034 ABC transporter signature motif; other site 553190001035 Walker B; other site 553190001036 D-loop; other site 553190001037 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 553190001038 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 553190001039 Major Facilitator Superfamily; Region: MFS_1; pfam07690 553190001040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553190001041 putative substrate translocation pore; other site 553190001042 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553190001043 putative substrate translocation pore; other site 553190001044 Domain of unknown function (DUF348); Region: DUF348; pfam03990 553190001045 G5 domain; Region: G5; pfam07501 553190001046 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 553190001047 catalytic residue [active] 553190001048 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 553190001049 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 553190001050 catalytic residues [active] 553190001051 seryl-tRNA synthetase; Provisional; Region: PRK05431 553190001052 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 553190001053 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 553190001054 dimer interface [polypeptide binding]; other site 553190001055 active site 553190001056 motif 1; other site 553190001057 motif 2; other site 553190001058 motif 3; other site 553190001059 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 553190001060 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 553190001061 dimer interface [polypeptide binding]; other site 553190001062 active site 553190001063 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 553190001064 homodimer interface [polypeptide binding]; other site 553190001065 helix swapped region; other site 553190001066 substrate binding pocket [chemical binding]; other site 553190001067 catalytic residues [active] 553190001068 NADH/NADPH cofactor binding site [chemical binding]; other site 553190001069 putative acyltransferase; Provisional; Region: PRK05790 553190001070 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 553190001071 dimer interface [polypeptide binding]; other site 553190001072 active site 553190001073 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 553190001074 active site 553190001075 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 553190001076 Part of AAA domain; Region: AAA_19; pfam13245 553190001077 Family description; Region: UvrD_C_2; pfam13538 553190001078 Domain of unknown function (DUF4418); Region: DUF4418; pfam14387 553190001079 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 553190001080 FtsX-like permease family; Region: FtsX; pfam02687 553190001081 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 553190001082 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 553190001083 Walker A/P-loop; other site 553190001084 ATP binding site [chemical binding]; other site 553190001085 Q-loop/lid; other site 553190001086 ABC transporter signature motif; other site 553190001087 Walker B; other site 553190001088 D-loop; other site 553190001089 H-loop/switch region; other site 553190001090 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 553190001091 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 553190001092 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 553190001093 RNA binding surface [nucleotide binding]; other site 553190001094 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 553190001095 catalytic core [active] 553190001096 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 553190001097 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 553190001098 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 553190001099 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 553190001100 motif 1; other site 553190001101 active site 553190001102 motif 2; other site 553190001103 motif 3; other site 553190001104 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 553190001105 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 553190001106 YceG-like family; Region: YceG; pfam02618 553190001107 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 553190001108 dimerization interface [polypeptide binding]; other site 553190001109 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 553190001110 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 553190001111 Tetramer interface [polypeptide binding]; other site 553190001112 active site 553190001113 FMN-binding site [chemical binding]; other site 553190001114 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 553190001115 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 553190001116 ADP binding site [chemical binding]; other site 553190001117 magnesium binding site [ion binding]; other site 553190001118 putative shikimate binding site; other site 553190001119 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 553190001120 active site 553190001121 dimer interface [polypeptide binding]; other site 553190001122 metal binding site [ion binding]; metal-binding site 553190001123 Dehydroquinase class II; Region: DHquinase_II; pfam01220 553190001124 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 553190001125 trimer interface [polypeptide binding]; other site 553190001126 active site 553190001127 dimer interface [polypeptide binding]; other site 553190001128 CTP synthetase; Validated; Region: pyrG; PRK05380 553190001129 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 553190001130 Catalytic site [active] 553190001131 active site 553190001132 UTP binding site [chemical binding]; other site 553190001133 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 553190001134 active site 553190001135 putative oxyanion hole; other site 553190001136 catalytic triad [active] 553190001137 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 553190001138 FeS assembly protein SufB; Region: sufB; TIGR01980 553190001139 FeS assembly protein SufD; Region: sufD; TIGR01981 553190001140 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 553190001141 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 553190001142 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 553190001143 Walker A/P-loop; other site 553190001144 ATP binding site [chemical binding]; other site 553190001145 Q-loop/lid; other site 553190001146 ABC transporter signature motif; other site 553190001147 Walker B; other site 553190001148 D-loop; other site 553190001149 H-loop/switch region; other site 553190001150 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 553190001151 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 553190001152 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 553190001153 catalytic residue [active] 553190001154 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 553190001155 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 553190001156 active site 553190001157 trimerization site [polypeptide binding]; other site 553190001158 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 553190001159 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 553190001160 Protein of unknown function (DUF4125); Region: DUF4125; pfam13526 553190001161 Tetratricopeptide repeat; Region: TPR_12; pfam13424 553190001162 Tetratricopeptide repeat; Region: TPR_12; pfam13424 553190001163 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 553190001164 binding surface 553190001165 TPR motif; other site 553190001166 Tetratricopeptide repeat; Region: TPR_12; pfam13424 553190001167 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 553190001168 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 553190001169 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 553190001170 dimer interface [polypeptide binding]; other site 553190001171 putative anticodon binding site; other site 553190001172 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 553190001173 motif 1; other site 553190001174 dimer interface [polypeptide binding]; other site 553190001175 active site 553190001176 motif 2; other site 553190001177 motif 3; other site 553190001178 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 553190001179 catalytic core [active] 553190001180 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 553190001181 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 553190001182 PhoU domain; Region: PhoU; pfam01895 553190001183 PhoU domain; Region: PhoU; pfam01895 553190001184 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 553190001185 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 553190001186 dimer interface [polypeptide binding]; other site 553190001187 phosphorylation site [posttranslational modification] 553190001188 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 553190001189 ATP binding site [chemical binding]; other site 553190001190 Mg2+ binding site [ion binding]; other site 553190001191 G-X-G motif; other site 553190001192 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 553190001193 Surface antigen [General function prediction only]; Region: COG3942 553190001194 CHAP domain; Region: CHAP; pfam05257 553190001195 NlpC/P60 family; Region: NLPC_P60; pfam00877 553190001196 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 553190001197 Ligand Binding Site [chemical binding]; other site 553190001198 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 553190001199 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 553190001200 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 553190001201 OsmC-like protein; Region: OsmC; pfam02566 553190001202 thymidylate synthase; Reviewed; Region: thyA; PRK01827 553190001203 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 553190001204 dimerization interface [polypeptide binding]; other site 553190001205 active site 553190001206 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 553190001207 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 553190001208 folate binding site [chemical binding]; other site 553190001209 NADP+ binding site [chemical binding]; other site 553190001210 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 553190001211 Low molecular weight phosphatase family; Region: LMWPc; cl00105 553190001212 active site 553190001213 hypothetical protein; Provisional; Region: PRK07907 553190001214 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 553190001215 active site 553190001216 metal binding site [ion binding]; metal-binding site 553190001217 dimer interface [polypeptide binding]; other site 553190001218 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 553190001219 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 553190001220 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 553190001221 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 553190001222 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 553190001223 Walker A/P-loop; other site 553190001224 ATP binding site [chemical binding]; other site 553190001225 Q-loop/lid; other site 553190001226 ABC transporter signature motif; other site 553190001227 Walker B; other site 553190001228 D-loop; other site 553190001229 H-loop/switch region; other site 553190001230 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 553190001231 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 553190001232 Walker A/P-loop; other site 553190001233 ATP binding site [chemical binding]; other site 553190001234 Q-loop/lid; other site 553190001235 ABC transporter signature motif; other site 553190001236 Walker B; other site 553190001237 D-loop; other site 553190001238 H-loop/switch region; other site 553190001239 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 553190001240 Abi-like protein; Region: Abi_2; pfam07751 553190001241 Cna protein B-type domain; Region: Cna_B; pfam05738 553190001242 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 553190001243 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 553190001244 active site 553190001245 catalytic site [active] 553190001246 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 553190001247 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 553190001248 putative active site [active] 553190001249 catalytic triad [active] 553190001250 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 553190001251 PA/protease or protease-like domain interface [polypeptide binding]; other site 553190001252 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 553190001253 catalytic residues [active] 553190001254 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 553190001255 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 553190001256 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 553190001257 active site 553190001258 catalytic site [active] 553190001259 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 553190001260 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 553190001261 generic binding surface II; other site 553190001262 generic binding surface I; other site 553190001263 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 553190001264 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 553190001265 Abi-like protein; Region: Abi_2; pfam07751 553190001266 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 553190001267 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 553190001268 HIGH motif; other site 553190001269 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 553190001270 active site 553190001271 KMSKS motif; other site 553190001272 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 553190001273 tRNA binding surface [nucleotide binding]; other site 553190001274 anticodon binding site; other site 553190001275 Protein of unknown function (DUF497); Region: DUF497; pfam04365 553190001276 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 553190001277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553190001278 dimer interface [polypeptide binding]; other site 553190001279 conserved gate region; other site 553190001280 putative PBP binding loops; other site 553190001281 ABC-ATPase subunit interface; other site 553190001282 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 553190001283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553190001284 dimer interface [polypeptide binding]; other site 553190001285 conserved gate region; other site 553190001286 ABC-ATPase subunit interface; other site 553190001287 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 553190001288 peptide binding site [polypeptide binding]; other site 553190001289 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 553190001290 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 553190001291 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 553190001292 Walker A/P-loop; other site 553190001293 ATP binding site [chemical binding]; other site 553190001294 Q-loop/lid; other site 553190001295 ABC transporter signature motif; other site 553190001296 Walker B; other site 553190001297 D-loop; other site 553190001298 H-loop/switch region; other site 553190001299 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 553190001300 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 553190001301 Walker A/P-loop; other site 553190001302 ATP binding site [chemical binding]; other site 553190001303 Q-loop/lid; other site 553190001304 ABC transporter signature motif; other site 553190001305 Walker B; other site 553190001306 D-loop; other site 553190001307 H-loop/switch region; other site 553190001308 glutamate racemase; Provisional; Region: PRK00865 553190001309 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 553190001310 putative active site [active] 553190001311 redox center [active] 553190001312 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 553190001313 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 553190001314 active site 553190001315 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 553190001316 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 553190001317 Phosphotransferase enzyme family; Region: APH; pfam01636 553190001318 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 553190001319 active site 553190001320 ATP binding site [chemical binding]; other site 553190001321 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 553190001322 Part of AAA domain; Region: AAA_19; pfam13245 553190001323 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 553190001324 Family description; Region: UvrD_C_2; pfam13538 553190001325 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 553190001326 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 553190001327 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 553190001328 DivIVA domain; Region: DivI1A_domain; TIGR03544 553190001329 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 553190001330 Recombination protein O N terminal; Region: RecO_N; pfam11967 553190001331 Recombination protein O C terminal; Region: RecO_C; pfam02565 553190001332 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829 553190001333 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 553190001334 catalytic residue [active] 553190001335 putative FPP diphosphate binding site; other site 553190001336 putative FPP binding hydrophobic cleft; other site 553190001337 dimer interface [polypeptide binding]; other site 553190001338 putative IPP diphosphate binding site; other site 553190001339 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 553190001340 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 553190001341 metal binding site [ion binding]; metal-binding site 553190001342 putative dimer interface [polypeptide binding]; other site 553190001343 Domain of unknown function DUF77; Region: DUF77; pfam01910 553190001344 glycyl-tRNA synthetase; Provisional; Region: PRK04173 553190001345 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 553190001346 motif 1; other site 553190001347 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 553190001348 active site 553190001349 motif 2; other site 553190001350 motif 3; other site 553190001351 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 553190001352 anticodon binding site; other site 553190001353 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 553190001354 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 553190001355 FMN binding site [chemical binding]; other site 553190001356 active site 553190001357 catalytic residues [active] 553190001358 substrate binding site [chemical binding]; other site 553190001359 cell division protein FtsZ; Validated; Region: PRK09330 553190001360 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 553190001361 nucleotide binding site [chemical binding]; other site 553190001362 SulA interaction site; other site 553190001363 Protein of unknown function (DUF552); Region: DUF552; pfam04472 553190001364 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 553190001365 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 553190001366 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 553190001367 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 553190001368 putative substrate binding site [chemical binding]; other site 553190001369 putative ATP binding site [chemical binding]; other site 553190001370 proline aminopeptidase P II; Provisional; Region: PRK10879 553190001371 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 553190001372 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 553190001373 active site 553190001374 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 553190001375 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 553190001376 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 553190001377 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 553190001378 aspartate racemase; Region: asp_race; TIGR00035 553190001379 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 553190001380 ATP-grasp domain; Region: ATP-grasp_4; cl17255 553190001381 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 553190001382 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 553190001383 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 553190001384 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 553190001385 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 553190001386 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 553190001387 active site 553190001388 catalytic site [active] 553190001389 substrate binding site [chemical binding]; other site 553190001390 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 553190001391 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 553190001392 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 553190001393 DNA binding residues [nucleotide binding] 553190001394 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 553190001395 putative deacylase active site [active] 553190001396 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 553190001397 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 553190001398 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 553190001399 Thiamine pyrophosphokinase; Region: TPK; cd07995 553190001400 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 553190001401 active site 553190001402 dimerization interface [polypeptide binding]; other site 553190001403 thiamine binding site [chemical binding]; other site 553190001404 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 553190001405 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 553190001406 active site 553190001407 dimer interface [polypeptide binding]; other site 553190001408 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 553190001409 Ligand Binding Site [chemical binding]; other site 553190001410 Molecular Tunnel; other site 553190001411 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 553190001412 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 553190001413 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 553190001414 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 553190001415 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 553190001416 23S rRNA binding site [nucleotide binding]; other site 553190001417 L21 binding site [polypeptide binding]; other site 553190001418 L13 binding site [polypeptide binding]; other site 553190001419 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 553190001420 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 553190001421 active site 553190001422 DNA binding site [nucleotide binding] 553190001423 Int/Topo IB signature motif; other site 553190001424 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 553190001425 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 553190001426 P-loop; other site 553190001427 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 553190001428 Magnesium ion binding site [ion binding]; other site 553190001429 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 553190001430 Magnesium ion binding site [ion binding]; other site 553190001431 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 553190001432 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 553190001433 G1 box; other site 553190001434 putative GEF interaction site [polypeptide binding]; other site 553190001435 GTP/Mg2+ binding site [chemical binding]; other site 553190001436 Switch I region; other site 553190001437 G2 box; other site 553190001438 G3 box; other site 553190001439 Switch II region; other site 553190001440 G4 box; other site 553190001441 G5 box; other site 553190001442 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 553190001443 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 553190001444 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 553190001445 Prephenate dehydratase; Region: PDT; pfam00800 553190001446 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 553190001447 putative L-Phe binding site [chemical binding]; other site 553190001448 prephenate dehydrogenase; Validated; Region: PRK06545 553190001449 prephenate dehydrogenase; Validated; Region: PRK08507 553190001450 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 553190001451 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 553190001452 active site 553190001453 DNA binding site [nucleotide binding] 553190001454 Int/Topo IB signature motif; other site 553190001455 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 553190001456 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 553190001457 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 553190001458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553190001459 dimer interface [polypeptide binding]; other site 553190001460 conserved gate region; other site 553190001461 putative PBP binding loops; other site 553190001462 ABC-ATPase subunit interface; other site 553190001463 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 553190001464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553190001465 dimer interface [polypeptide binding]; other site 553190001466 conserved gate region; other site 553190001467 putative PBP binding loops; other site 553190001468 ABC-ATPase subunit interface; other site 553190001469 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 553190001470 AAA domain; Region: AAA_21; pfam13304 553190001471 Walker A/P-loop; other site 553190001472 ATP binding site [chemical binding]; other site 553190001473 Q-loop/lid; other site 553190001474 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 553190001475 ABC transporter signature motif; other site 553190001476 Walker B; other site 553190001477 D-loop; other site 553190001478 H-loop/switch region; other site 553190001479 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 553190001480 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 553190001481 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 553190001482 Walker A/P-loop; other site 553190001483 ATP binding site [chemical binding]; other site 553190001484 Q-loop/lid; other site 553190001485 ABC transporter signature motif; other site 553190001486 Walker B; other site 553190001487 D-loop; other site 553190001488 H-loop/switch region; other site 553190001489 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 553190001490 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 553190001491 putative active site [active] 553190001492 putative catalytic site [active] 553190001493 putative DNA binding site [nucleotide binding]; other site 553190001494 putative phosphate binding site [ion binding]; other site 553190001495 metal binding site A [ion binding]; metal-binding site 553190001496 putative AP binding site [nucleotide binding]; other site 553190001497 putative metal binding site B [ion binding]; other site 553190001498 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 553190001499 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 553190001500 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 553190001501 TRAM domain; Region: TRAM; pfam01938 553190001502 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 553190001503 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 553190001504 catalytic residues [active] 553190001505 catalytic nucleophile [active] 553190001506 Recombinase; Region: Recombinase; pfam07508 553190001507 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 553190001508 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 553190001509 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 553190001510 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 553190001511 active site 553190001512 catalytic motif [active] 553190001513 Zn binding site [ion binding]; other site 553190001514 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 553190001515 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 553190001516 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 553190001517 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 553190001518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 553190001519 active site 553190001520 phosphorylation site [posttranslational modification] 553190001521 intermolecular recognition site; other site 553190001522 dimerization interface [polypeptide binding]; other site 553190001523 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 553190001524 DNA binding residues [nucleotide binding] 553190001525 dimerization interface [polypeptide binding]; other site 553190001526 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 553190001527 RelB antitoxin; Region: RelB; cl01171 553190001528 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 553190001529 Integrase core domain; Region: rve; pfam00665 553190001530 Integrase core domain; Region: rve_2; pfam13333 553190001531 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 553190001532 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 553190001533 non-specific DNA binding site [nucleotide binding]; other site 553190001534 salt bridge; other site 553190001535 sequence-specific DNA binding site [nucleotide binding]; other site 553190001536 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 553190001537 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 553190001538 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 553190001539 non-specific DNA binding site [nucleotide binding]; other site 553190001540 salt bridge; other site 553190001541 sequence-specific DNA binding site [nucleotide binding]; other site 553190001542 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 553190001543 non-specific DNA binding site [nucleotide binding]; other site 553190001544 salt bridge; other site 553190001545 sequence-specific DNA binding site [nucleotide binding]; other site 553190001546 addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384 553190001547 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 553190001548 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553190001549 Walker A/P-loop; other site 553190001550 ATP binding site [chemical binding]; other site 553190001551 Q-loop/lid; other site 553190001552 ABC transporter signature motif; other site 553190001553 Walker B; other site 553190001554 D-loop; other site 553190001555 H-loop/switch region; other site 553190001556 ABC-2 type transporter; Region: ABC2_membrane; cl17235 553190001557 RelB antitoxin; Region: RelB; cl01171 553190001558 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 553190001559 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 553190001560 catalytic residues [active] 553190001561 Helix-turn-helix domain; Region: HTH_17; pfam12728 553190001562 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 553190001563 DNA methylase; Region: N6_N4_Mtase; pfam01555 553190001564 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 553190001565 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 553190001566 cofactor binding site; other site 553190001567 DNA binding site [nucleotide binding] 553190001568 substrate interaction site [chemical binding]; other site 553190001569 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 553190001570 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 553190001571 LlaJI restriction endonuclease; Region: RE_LlaJI; pfam09563 553190001572 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 553190001573 YcaO-like family; Region: YcaO; pfam02624 553190001574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553190001575 Major Facilitator Superfamily; Region: MFS_1; pfam07690 553190001576 GA module; Region: GA; smart00844 553190001577 Predicted membrane protein [Function unknown]; Region: COG1511 553190001578 serine/threonine transporter SstT; Provisional; Region: PRK13628 553190001579 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 553190001580 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 553190001581 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 553190001582 dimer interface [polypeptide binding]; other site 553190001583 pyridoxal 5'-phosphate binding site [chemical binding]; other site 553190001584 catalytic residue [active] 553190001585 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 553190001586 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 553190001587 Coenzyme A binding pocket [chemical binding]; other site 553190001588 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 553190001589 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 553190001590 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 553190001591 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 553190001592 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553190001593 Walker A/P-loop; other site 553190001594 ATP binding site [chemical binding]; other site 553190001595 Q-loop/lid; other site 553190001596 ABC transporter signature motif; other site 553190001597 Walker B; other site 553190001598 D-loop; other site 553190001599 H-loop/switch region; other site 553190001600 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 553190001601 LemA family; Region: LemA; cl00742 553190001602 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 553190001603 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 553190001604 Predicted permease [General function prediction only]; Region: COG2056 553190001605 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 553190001606 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 553190001607 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553190001608 Q-loop/lid; other site 553190001609 ABC transporter signature motif; other site 553190001610 Walker B; other site 553190001611 H-loop/switch region; other site 553190001612 Predicted membrane protein [Function unknown]; Region: COG1511 553190001613 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 553190001614 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 553190001615 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 553190001616 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 553190001617 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 553190001618 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 553190001619 active site 553190001620 NAD binding site [chemical binding]; other site 553190001621 metal binding site [ion binding]; metal-binding site 553190001622 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 553190001623 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 553190001624 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 553190001625 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 553190001626 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 553190001627 putative substrate binding pocket [chemical binding]; other site 553190001628 AC domain interface; other site 553190001629 catalytic triad [active] 553190001630 AB domain interface; other site 553190001631 interchain disulfide; other site 553190001632 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 553190001633 HicB family; Region: HicB; pfam05534 553190001634 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 553190001635 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 553190001636 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 553190001637 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 553190001638 Soluble P-type ATPase [General function prediction only]; Region: COG4087 553190001639 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 553190001640 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 553190001641 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 553190001642 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 553190001643 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 553190001644 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 553190001645 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 553190001646 LexA repressor; Validated; Region: PRK00215 553190001647 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 553190001648 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 553190001649 Catalytic site [active] 553190001650 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 553190001651 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 553190001652 ATP cone domain; Region: ATP-cone; pfam03477 553190001653 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 553190001654 Part of AAA domain; Region: AAA_19; pfam13245 553190001655 Family description; Region: UvrD_C_2; pfam13538 553190001656 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 553190001657 active site 553190001658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553190001659 Major Facilitator Superfamily; Region: MFS_1; pfam07690 553190001660 putative substrate translocation pore; other site 553190001661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553190001662 Major Facilitator Superfamily; Region: MFS_1; pfam07690 553190001663 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 553190001664 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 553190001665 ATP binding site [chemical binding]; other site 553190001666 putative Mg++ binding site [ion binding]; other site 553190001667 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 553190001668 nucleotide binding region [chemical binding]; other site 553190001669 ATP-binding site [chemical binding]; other site 553190001670 Helicase associated domain (HA2); Region: HA2; pfam04408 553190001671 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 553190001672 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 553190001673 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 553190001674 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 553190001675 S-adenosylmethionine binding site [chemical binding]; other site 553190001676 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 553190001677 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 553190001678 HflX GTPase family; Region: HflX; cd01878 553190001679 G1 box; other site 553190001680 GTP/Mg2+ binding site [chemical binding]; other site 553190001681 Switch I region; other site 553190001682 G2 box; other site 553190001683 G3 box; other site 553190001684 Switch II region; other site 553190001685 G4 box; other site 553190001686 G5 box; other site 553190001687 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 553190001688 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 553190001689 NAD binding site [chemical binding]; other site 553190001690 dimer interface [polypeptide binding]; other site 553190001691 substrate binding site [chemical binding]; other site 553190001692 tetramer (dimer of dimers) interface [polypeptide binding]; other site 553190001693 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 553190001694 PAS fold; Region: PAS_4; pfam08448 553190001695 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 553190001696 Histidine kinase; Region: HisKA_2; pfam07568 553190001697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 553190001698 ATP binding site [chemical binding]; other site 553190001699 Mg2+ binding site [ion binding]; other site 553190001700 G-X-G motif; other site 553190001701 Transcription factor WhiB; Region: Whib; pfam02467 553190001702 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 553190001703 Transcriptional regulator [Transcription]; Region: LytR; COG1316 553190001704 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 553190001705 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 553190001706 Eukaryotic phosphomannomutase; Region: PMM; cl17107 553190001707 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 553190001708 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 553190001709 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 553190001710 active site 553190001711 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 553190001712 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 553190001713 dimerization interface [polypeptide binding]; other site 553190001714 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 553190001715 dimer interface [polypeptide binding]; other site 553190001716 phosphorylation site [posttranslational modification] 553190001717 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 553190001718 ATP binding site [chemical binding]; other site 553190001719 Mg2+ binding site [ion binding]; other site 553190001720 G-X-G motif; other site 553190001721 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 553190001722 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 553190001723 active site 553190001724 phosphorylation site [posttranslational modification] 553190001725 intermolecular recognition site; other site 553190001726 dimerization interface [polypeptide binding]; other site 553190001727 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 553190001728 DNA binding site [nucleotide binding] 553190001729 glycogen branching enzyme; Provisional; Region: PRK05402 553190001730 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 553190001731 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 553190001732 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 553190001733 active site 553190001734 catalytic site [active] 553190001735 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 553190001736 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 553190001737 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 553190001738 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 553190001739 intersubunit interface [polypeptide binding]; other site 553190001740 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 553190001741 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 553190001742 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 553190001743 homodimer interface [polypeptide binding]; other site 553190001744 NADP binding site [chemical binding]; other site 553190001745 substrate binding site [chemical binding]; other site 553190001746 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 553190001747 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 553190001748 RNA binding site [nucleotide binding]; other site 553190001749 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 553190001750 RNA binding site [nucleotide binding]; other site 553190001751 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 553190001752 RNA binding site [nucleotide binding]; other site 553190001753 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 553190001754 RNA binding site [nucleotide binding]; other site 553190001755 TM2 domain; Region: TM2; pfam05154 553190001756 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 553190001757 active site 553190001758 TM2 domain; Region: TM2; pfam05154 553190001759 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 553190001760 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 553190001761 CoA-binding site [chemical binding]; other site 553190001762 ATP-binding [chemical binding]; other site 553190001763 excinuclease ABC subunit B; Provisional; Region: PRK05298 553190001764 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 553190001765 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 553190001766 nucleotide binding region [chemical binding]; other site 553190001767 ATP-binding site [chemical binding]; other site 553190001768 Ultra-violet resistance protein B; Region: UvrB; pfam12344 553190001769 UvrB/uvrC motif; Region: UVR; pfam02151 553190001770 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 553190001771 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 553190001772 domain interfaces; other site 553190001773 active site 553190001774 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 553190001775 active site 553190001776 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 553190001777 Ca binding site [ion binding]; other site 553190001778 catalytic site [active] 553190001779 Aamy_C domain; Region: Aamy_C; smart00632 553190001780 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 553190001781 active site 553190001782 Ca binding site [ion binding]; other site 553190001783 catalytic site [active] 553190001784 Aamy_C domain; Region: Aamy_C; smart00632 553190001785 Carbohydrate binding domain (family 25); Region: CBM_25; cl04060 553190001786 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 553190001787 carbohydrate binding site [chemical binding]; other site 553190001788 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 553190001789 carbohydrate binding site [chemical binding]; other site 553190001790 pullulanase, type I; Region: pulA_typeI; TIGR02104 553190001791 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 553190001792 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 553190001793 Ca binding site [ion binding]; other site 553190001794 active site 553190001795 catalytic site [active] 553190001796 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 553190001797 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 553190001798 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 553190001799 Walker A/P-loop; other site 553190001800 ATP binding site [chemical binding]; other site 553190001801 Q-loop/lid; other site 553190001802 ABC transporter signature motif; other site 553190001803 Walker B; other site 553190001804 D-loop; other site 553190001805 H-loop/switch region; other site 553190001806 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 553190001807 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 553190001808 Walker A/P-loop; other site 553190001809 ATP binding site [chemical binding]; other site 553190001810 Q-loop/lid; other site 553190001811 ABC transporter signature motif; other site 553190001812 Walker B; other site 553190001813 D-loop; other site 553190001814 H-loop/switch region; other site 553190001815 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 553190001816 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 553190001817 UbiA prenyltransferase family; Region: UbiA; pfam01040 553190001818 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 553190001819 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 553190001820 active site 553190001821 phosphorylation site [posttranslational modification] 553190001822 intermolecular recognition site; other site 553190001823 dimerization interface [polypeptide binding]; other site 553190001824 ANTAR domain; Region: ANTAR; pfam03861 553190001825 5'-3' exonuclease; Region: 53EXOc; smart00475 553190001826 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 553190001827 active site 553190001828 metal binding site 1 [ion binding]; metal-binding site 553190001829 putative 5' ssDNA interaction site; other site 553190001830 metal binding site 3; metal-binding site 553190001831 metal binding site 2 [ion binding]; metal-binding site 553190001832 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 553190001833 putative DNA binding site [nucleotide binding]; other site 553190001834 putative metal binding site [ion binding]; other site 553190001835 DNA polymerase I; Provisional; Region: PRK05755 553190001836 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 553190001837 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 553190001838 active site 553190001839 DNA binding site [nucleotide binding] 553190001840 catalytic site [active] 553190001841 Uncharacterized conserved protein [Function unknown]; Region: COG0327 553190001842 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 553190001843 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 553190001844 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 553190001845 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 553190001846 active site 553190001847 catalytic site [active] 553190001848 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 553190001849 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 553190001850 hinge; other site 553190001851 active site 553190001852 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 553190001853 propionate/acetate kinase; Provisional; Region: PRK12379 553190001854 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 553190001855 putative phosphoketolase; Provisional; Region: PRK05261 553190001856 XFP N-terminal domain; Region: XFP_N; pfam09364 553190001857 XFP C-terminal domain; Region: XFP_C; pfam09363 553190001858 GMP synthase; Reviewed; Region: guaA; PRK00074 553190001859 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 553190001860 AMP/PPi binding site [chemical binding]; other site 553190001861 candidate oxyanion hole; other site 553190001862 catalytic triad [active] 553190001863 potential glutamine specificity residues [chemical binding]; other site 553190001864 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 553190001865 ATP Binding subdomain [chemical binding]; other site 553190001866 Ligand Binding sites [chemical binding]; other site 553190001867 Dimerization subdomain; other site 553190001868 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 553190001869 Penicillinase repressor; Region: Pencillinase_R; pfam03965 553190001870 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 553190001871 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 553190001872 Soluble P-type ATPase [General function prediction only]; Region: COG4087 553190001873 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 553190001874 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 553190001875 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 553190001876 DNA-binding site [nucleotide binding]; DNA binding site 553190001877 UTRA domain; Region: UTRA; pfam07702 553190001878 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 553190001879 L-aspartate oxidase; Provisional; Region: PRK06175 553190001880 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 553190001881 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 553190001882 DNA protecting protein DprA; Region: dprA; TIGR00732 553190001883 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 553190001884 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 553190001885 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 553190001886 Walker A motif; other site 553190001887 ATP binding site [chemical binding]; other site 553190001888 Walker B motif; other site 553190001889 arginine finger; other site 553190001890 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 553190001891 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 553190001892 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 553190001893 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 553190001894 homodimer interface [polypeptide binding]; other site 553190001895 substrate-cofactor binding pocket; other site 553190001896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 553190001897 catalytic residue [active] 553190001898 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 553190001899 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 553190001900 Walker A/P-loop; other site 553190001901 ATP binding site [chemical binding]; other site 553190001902 Q-loop/lid; other site 553190001903 ABC transporter signature motif; other site 553190001904 Walker B; other site 553190001905 D-loop; other site 553190001906 H-loop/switch region; other site 553190001907 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 553190001908 FtsX-like permease family; Region: FtsX; pfam02687 553190001909 FtsX-like permease family; Region: FtsX; pfam02687 553190001910 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 553190001911 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 553190001912 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 553190001913 active site 553190001914 phosphorylation site [posttranslational modification] 553190001915 intermolecular recognition site; other site 553190001916 dimerization interface [polypeptide binding]; other site 553190001917 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 553190001918 DNA binding residues [nucleotide binding] 553190001919 dimerization interface [polypeptide binding]; other site 553190001920 Histidine kinase; Region: HisKA_3; pfam07730 553190001921 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 553190001922 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 553190001923 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 553190001924 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 553190001925 GTP-binding protein YchF; Reviewed; Region: PRK09601 553190001926 YchF GTPase; Region: YchF; cd01900 553190001927 G1 box; other site 553190001928 GTP/Mg2+ binding site [chemical binding]; other site 553190001929 Switch I region; other site 553190001930 G2 box; other site 553190001931 Switch II region; other site 553190001932 G3 box; other site 553190001933 G4 box; other site 553190001934 G5 box; other site 553190001935 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 553190001936 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 553190001937 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 553190001938 Predicted membrane protein [Function unknown]; Region: COG2855 553190001939 Uncharacterized conserved protein [Function unknown]; Region: COG3189 553190001940 uracil transporter; Provisional; Region: PRK10720 553190001941 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 553190001942 Uncharacterized conserved protein [Function unknown]; Region: COG1615 553190001943 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 553190001944 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553190001945 dimer interface [polypeptide binding]; other site 553190001946 conserved gate region; other site 553190001947 putative PBP binding loops; other site 553190001948 ABC-ATPase subunit interface; other site 553190001949 NMT1/THI5 like; Region: NMT1; pfam09084 553190001950 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 553190001951 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 553190001952 putative active site [active] 553190001953 catalytic residue [active] 553190001954 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 553190001955 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 553190001956 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 553190001957 ATP binding site [chemical binding]; other site 553190001958 putative Mg++ binding site [ion binding]; other site 553190001959 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 553190001960 nucleotide binding region [chemical binding]; other site 553190001961 ATP-binding site [chemical binding]; other site 553190001962 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 553190001963 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 553190001964 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 553190001965 Walker A/P-loop; other site 553190001966 ATP binding site [chemical binding]; other site 553190001967 Q-loop/lid; other site 553190001968 ABC transporter signature motif; other site 553190001969 Walker B; other site 553190001970 D-loop; other site 553190001971 H-loop/switch region; other site 553190001972 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 553190001973 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 553190001974 substrate binding pocket [chemical binding]; other site 553190001975 membrane-bound complex binding site; other site 553190001976 hinge residues; other site 553190001977 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 553190001978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553190001979 putative PBP binding loops; other site 553190001980 dimer interface [polypeptide binding]; other site 553190001981 ABC-ATPase subunit interface; other site 553190001982 enolase; Provisional; Region: eno; PRK00077 553190001983 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 553190001984 dimer interface [polypeptide binding]; other site 553190001985 metal binding site [ion binding]; metal-binding site 553190001986 substrate binding pocket [chemical binding]; other site 553190001987 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 553190001988 tetramer (dimer of dimers) interface [polypeptide binding]; other site 553190001989 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 553190001990 NAD binding site [chemical binding]; other site 553190001991 dimer interface [polypeptide binding]; other site 553190001992 substrate binding site [chemical binding]; other site 553190001993 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 553190001994 catalytic center binding site [active] 553190001995 ATP binding site [chemical binding]; other site 553190001996 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 553190001997 dihydropteroate synthase; Region: DHPS; TIGR01496 553190001998 substrate binding pocket [chemical binding]; other site 553190001999 dimer interface [polypeptide binding]; other site 553190002000 inhibitor binding site; inhibition site 553190002001 Septum formation initiator; Region: DivIC; pfam04977 553190002002 Protein of unknown function (DUF501); Region: DUF501; pfam04417 553190002003 exopolyphosphatase; Region: exo_poly_only; TIGR03706 553190002004 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 553190002005 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 553190002006 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 553190002007 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 553190002008 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 553190002009 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 553190002010 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 553190002011 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 553190002012 dimer interface [polypeptide binding]; other site 553190002013 motif 1; other site 553190002014 active site 553190002015 motif 2; other site 553190002016 motif 3; other site 553190002017 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 553190002018 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 553190002019 putative tRNA-binding site [nucleotide binding]; other site 553190002020 B3/4 domain; Region: B3_4; pfam03483 553190002021 tRNA synthetase B5 domain; Region: B5; pfam03484 553190002022 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 553190002023 dimer interface [polypeptide binding]; other site 553190002024 motif 1; other site 553190002025 motif 3; other site 553190002026 motif 2; other site 553190002027 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 553190002028 Arginine repressor [Transcription]; Region: ArgR; COG1438 553190002029 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 553190002030 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 553190002031 argininosuccinate synthase; Provisional; Region: PRK13820 553190002032 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 553190002033 ANP binding site [chemical binding]; other site 553190002034 Substrate Binding Site II [chemical binding]; other site 553190002035 Substrate Binding Site I [chemical binding]; other site 553190002036 argininosuccinate lyase; Provisional; Region: PRK00855 553190002037 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 553190002038 active sites [active] 553190002039 tetramer interface [polypeptide binding]; other site 553190002040 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 553190002041 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 553190002042 active site 553190002043 HIGH motif; other site 553190002044 dimer interface [polypeptide binding]; other site 553190002045 KMSKS motif; other site 553190002046 S4 RNA-binding domain; Region: S4; smart00363 553190002047 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 553190002048 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 553190002049 active site 553190002050 motif I; other site 553190002051 motif II; other site 553190002052 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 553190002053 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 553190002054 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 553190002055 RNA binding surface [nucleotide binding]; other site 553190002056 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 553190002057 S-adenosylmethionine binding site [chemical binding]; other site 553190002058 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 553190002059 ATP-NAD kinase; Region: NAD_kinase; pfam01513 553190002060 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 553190002061 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 553190002062 Walker A/P-loop; other site 553190002063 ATP binding site [chemical binding]; other site 553190002064 Q-loop/lid; other site 553190002065 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 553190002066 ABC transporter signature motif; other site 553190002067 Walker B; other site 553190002068 D-loop; other site 553190002069 H-loop/switch region; other site 553190002070 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 553190002071 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 553190002072 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 553190002073 motif II; other site 553190002074 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 553190002075 30S subunit binding site; other site 553190002076 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 553190002077 DEAD/DEAH box helicase; Region: DEAD; pfam00270 553190002078 ATP binding site [chemical binding]; other site 553190002079 putative Mg++ binding site [ion binding]; other site 553190002080 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 553190002081 SEC-C motif; Region: SEC-C; pfam02810 553190002082 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 553190002083 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 553190002084 putative acyl-acceptor binding pocket; other site 553190002085 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 553190002086 Catalytic domain of Protein Kinases; Region: PKc; cd00180 553190002087 active site 553190002088 ATP binding site [chemical binding]; other site 553190002089 substrate binding site [chemical binding]; other site 553190002090 activation loop (A-loop); other site 553190002091 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 553190002092 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 553190002093 PASTA domain; Region: PASTA; pfam03793 553190002094 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 553190002095 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 553190002096 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 553190002097 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 553190002098 substrate binding pocket [chemical binding]; other site 553190002099 chain length determination region; other site 553190002100 substrate-Mg2+ binding site; other site 553190002101 catalytic residues [active] 553190002102 aspartate-rich region 1; other site 553190002103 active site lid residues [active] 553190002104 aspartate-rich region 2; other site 553190002105 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 553190002106 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 553190002107 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 553190002108 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 553190002109 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 553190002110 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 553190002111 DNA binding residues [nucleotide binding] 553190002112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 553190002113 ATP binding site [chemical binding]; other site 553190002114 Mg2+ binding site [ion binding]; other site 553190002115 G-X-G motif; other site 553190002116 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 553190002117 anchoring element; other site 553190002118 dimer interface [polypeptide binding]; other site 553190002119 ATP binding site [chemical binding]; other site 553190002120 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 553190002121 active site 553190002122 metal binding site [ion binding]; metal-binding site 553190002123 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 553190002124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553190002125 Major Facilitator Superfamily; Region: MFS_1; pfam07690 553190002126 putative substrate translocation pore; other site 553190002127 Protein of unknown function (DUF3791); Region: DUF3791; pfam12668 553190002128 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 553190002129 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 553190002130 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 553190002131 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 553190002132 CAP-like domain; other site 553190002133 active site 553190002134 primary dimer interface [polypeptide binding]; other site 553190002135 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 553190002136 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 553190002137 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 553190002138 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 553190002139 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 553190002140 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 553190002141 trimer interface [polypeptide binding]; other site 553190002142 active site 553190002143 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 553190002144 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 553190002145 Zn2+ binding site [ion binding]; other site 553190002146 Mg2+ binding site [ion binding]; other site 553190002147 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 553190002148 synthetase active site [active] 553190002149 NTP binding site [chemical binding]; other site 553190002150 metal binding site [ion binding]; metal-binding site 553190002151 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 553190002152 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 553190002153 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 553190002154 IHF dimer interface [polypeptide binding]; other site 553190002155 IHF - DNA interface [nucleotide binding]; other site 553190002156 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 553190002157 adenylosuccinate lyase; Provisional; Region: PRK09285 553190002158 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 553190002159 tetramer interface [polypeptide binding]; other site 553190002160 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 553190002161 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 553190002162 nucleophilic elbow; other site 553190002163 catalytic triad; other site 553190002164 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 553190002165 metal ion-dependent adhesion site (MIDAS); other site 553190002166 von Willebrand factor type A domain; Region: VWA_2; pfam13519 553190002167 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 553190002168 Protein of unknown function DUF58; Region: DUF58; pfam01882 553190002169 MoxR-like ATPases [General function prediction only]; Region: COG0714 553190002170 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 553190002171 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 553190002172 ligand binding site [chemical binding]; other site 553190002173 active site 553190002174 UGI interface [polypeptide binding]; other site 553190002175 catalytic site [active] 553190002176 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 553190002177 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 553190002178 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 553190002179 ring oligomerisation interface [polypeptide binding]; other site 553190002180 ATP/Mg binding site [chemical binding]; other site 553190002181 stacking interactions; other site 553190002182 hinge regions; other site 553190002183 Proteins of 100 residues with WXG; Region: WXG100; cl02005 553190002184 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 553190002185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 553190002186 active site 553190002187 phosphorylation site [posttranslational modification] 553190002188 intermolecular recognition site; other site 553190002189 dimerization interface [polypeptide binding]; other site 553190002190 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 553190002191 DNA binding site [nucleotide binding] 553190002192 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 553190002193 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 553190002194 dimerization interface [polypeptide binding]; other site 553190002195 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 553190002196 dimer interface [polypeptide binding]; other site 553190002197 phosphorylation site [posttranslational modification] 553190002198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 553190002199 ATP binding site [chemical binding]; other site 553190002200 Mg2+ binding site [ion binding]; other site 553190002201 G-X-G motif; other site 553190002202 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 553190002203 DNA-binding site [nucleotide binding]; DNA binding site 553190002204 RNA-binding motif; other site 553190002205 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 553190002206 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 553190002207 Clp amino terminal domain; Region: Clp_N; pfam02861 553190002208 Clp amino terminal domain; Region: Clp_N; pfam02861 553190002209 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 553190002210 Walker A motif; other site 553190002211 ATP binding site [chemical binding]; other site 553190002212 Walker B motif; other site 553190002213 arginine finger; other site 553190002214 UvrB/uvrC motif; Region: UVR; pfam02151 553190002215 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 553190002216 Walker A motif; other site 553190002217 ATP binding site [chemical binding]; other site 553190002218 Walker B motif; other site 553190002219 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 553190002220 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 553190002221 NUDIX domain; Region: NUDIX; pfam00293 553190002222 nudix motif; other site 553190002223 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 553190002224 active site 553190002225 catalytic motif [active] 553190002226 Zn binding site [ion binding]; other site 553190002227 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 553190002228 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 553190002229 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 553190002230 catalytic residues [active] 553190002231 AAA domain; Region: AAA_14; pfam13173 553190002232 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 553190002233 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 553190002234 RelB antitoxin; Region: RelB; cl01171 553190002235 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 553190002236 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 553190002237 active site 553190002238 NTP binding site [chemical binding]; other site 553190002239 metal binding triad [ion binding]; metal-binding site 553190002240 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 553190002241 MULE transposase domain; Region: MULE; pfam10551 553190002242 helicase Cas3; Provisional; Region: PRK09694 553190002243 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 553190002244 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 553190002245 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 553190002246 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 553190002247 CT1975-like protein; Region: Cas_CT1975; pfam09344 553190002248 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 553190002249 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 553190002250 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 553190002251 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 553190002252 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 553190002253 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 553190002254 active site 553190002255 catalytic site [active] 553190002256 substrate binding site [chemical binding]; other site 553190002257 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 553190002258 allantoate amidohydrolase; Region: AllC; TIGR03176 553190002259 active site 553190002260 metal binding site [ion binding]; metal-binding site 553190002261 dimer interface [polypeptide binding]; other site 553190002262 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 553190002263 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 553190002264 Na binding site [ion binding]; other site 553190002265 putative substrate binding site [chemical binding]; other site 553190002266 allantoinase; Provisional; Region: PRK08044 553190002267 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 553190002268 active site 553190002269 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 553190002270 thiS-thiF/thiG interaction site; other site 553190002271 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 553190002272 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 553190002273 ATP binding site [chemical binding]; other site 553190002274 substrate interface [chemical binding]; other site 553190002275 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 553190002276 ThiS interaction site; other site 553190002277 putative active site [active] 553190002278 tetramer interface [polypeptide binding]; other site 553190002279 TPR repeat; Region: TPR_11; pfam13414 553190002280 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 553190002281 binding surface 553190002282 TPR motif; other site 553190002283 Ligase N family; Region: LIGANc; smart00532 553190002284 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 553190002285 nucleotide binding pocket [chemical binding]; other site 553190002286 K-X-D-G motif; other site 553190002287 catalytic site [active] 553190002288 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 553190002289 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 553190002290 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 553190002291 Helix-hairpin-helix motif; Region: HHH; pfam00633 553190002292 helix-hairpin-helix signature motif; other site 553190002293 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 553190002294 Dimer interface [polypeptide binding]; other site 553190002295 antiporter inner membrane protein; Provisional; Region: PRK11670 553190002296 Domain of unknown function DUF59; Region: DUF59; cl00941 553190002297 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 553190002298 Walker A motif; other site 553190002299 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 553190002300 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 553190002301 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 553190002302 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 553190002303 dimer interface [polypeptide binding]; other site 553190002304 motif 1; other site 553190002305 active site 553190002306 motif 2; other site 553190002307 motif 3; other site 553190002308 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 553190002309 anticodon binding site; other site 553190002310 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 553190002311 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 553190002312 dimer interface [polypeptide binding]; other site 553190002313 anticodon binding site; other site 553190002314 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 553190002315 motif 1; other site 553190002316 dimer interface [polypeptide binding]; other site 553190002317 active site 553190002318 motif 2; other site 553190002319 GAD domain; Region: GAD; pfam02938 553190002320 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 553190002321 active site 553190002322 motif 3; other site 553190002323 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 553190002324 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 553190002325 Walker A/P-loop; other site 553190002326 ATP binding site [chemical binding]; other site 553190002327 Q-loop/lid; other site 553190002328 ABC transporter signature motif; other site 553190002329 Walker B; other site 553190002330 D-loop; other site 553190002331 H-loop/switch region; other site 553190002332 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 553190002333 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 553190002334 substrate binding pocket [chemical binding]; other site 553190002335 membrane-bound complex binding site; other site 553190002336 hinge residues; other site 553190002337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553190002338 dimer interface [polypeptide binding]; other site 553190002339 conserved gate region; other site 553190002340 ABC-ATPase subunit interface; other site 553190002341 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 553190002342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553190002343 dimer interface [polypeptide binding]; other site 553190002344 conserved gate region; other site 553190002345 putative PBP binding loops; other site 553190002346 ABC-ATPase subunit interface; other site 553190002347 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 553190002348 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 553190002349 active site 553190002350 Predicted transcriptional regulator [Transcription]; Region: COG2378 553190002351 WYL domain; Region: WYL; pfam13280 553190002352 DEAD-like helicases superfamily; Region: DEXDc; smart00487 553190002353 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 553190002354 ATP binding site [chemical binding]; other site 553190002355 putative Mg++ binding site [ion binding]; other site 553190002356 helicase superfamily c-terminal domain; Region: HELICc; smart00490 553190002357 nucleotide binding region [chemical binding]; other site 553190002358 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 553190002359 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 553190002360 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 553190002361 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 553190002362 motif II; other site 553190002363 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 553190002364 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 553190002365 DNA binding residues [nucleotide binding] 553190002366 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 553190002367 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 553190002368 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 553190002369 phosphopeptide binding site; other site 553190002370 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 553190002371 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 553190002372 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 553190002373 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 553190002374 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 553190002375 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 553190002376 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 553190002377 substrate binding site [chemical binding]; other site 553190002378 hexamer interface [polypeptide binding]; other site 553190002379 metal binding site [ion binding]; metal-binding site 553190002380 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 553190002381 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 553190002382 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 553190002383 ribosome recycling factor; Reviewed; Region: frr; PRK00083 553190002384 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 553190002385 hinge region; other site 553190002386 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 553190002387 putative nucleotide binding site [chemical binding]; other site 553190002388 uridine monophosphate binding site [chemical binding]; other site 553190002389 homohexameric interface [polypeptide binding]; other site 553190002390 elongation factor Ts; Provisional; Region: tsf; PRK09377 553190002391 UBA/TS-N domain; Region: UBA; pfam00627 553190002392 Elongation factor TS; Region: EF_TS; pfam00889 553190002393 Elongation factor TS; Region: EF_TS; pfam00889 553190002394 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 553190002395 rRNA interaction site [nucleotide binding]; other site 553190002396 S8 interaction site; other site 553190002397 putative laminin-1 binding site; other site 553190002398 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 553190002399 active site 553190002400 catalytic residues [active] 553190002401 metal binding site [ion binding]; metal-binding site 553190002402 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 553190002403 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 553190002404 acyl-activating enzyme (AAE) consensus motif; other site 553190002405 putative AMP binding site [chemical binding]; other site 553190002406 putative active site [active] 553190002407 putative CoA binding site [chemical binding]; other site 553190002408 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 553190002409 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 553190002410 active site 553190002411 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 553190002412 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 553190002413 GIY-YIG motif/motif A; other site 553190002414 active site 553190002415 catalytic site [active] 553190002416 putative DNA binding site [nucleotide binding]; other site 553190002417 metal binding site [ion binding]; metal-binding site 553190002418 UvrB/uvrC motif; Region: UVR; pfam02151 553190002419 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 553190002420 Helix-hairpin-helix motif; Region: HHH; pfam00633 553190002421 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 553190002422 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 553190002423 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 553190002424 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 553190002425 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 553190002426 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553190002427 Walker A/P-loop; other site 553190002428 ATP binding site [chemical binding]; other site 553190002429 Q-loop/lid; other site 553190002430 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 553190002431 ABC transporter signature motif; other site 553190002432 Walker B; other site 553190002433 D-loop; other site 553190002434 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 553190002435 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 553190002436 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 553190002437 pyridoxal 5'-phosphate binding site [chemical binding]; other site 553190002438 homodimer interface [polypeptide binding]; other site 553190002439 catalytic residue [active] 553190002440 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 553190002441 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 553190002442 nucleotide binding site [chemical binding]; other site 553190002443 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 553190002444 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 553190002445 active site 553190002446 Predicted membrane protein [Function unknown]; Region: COG3601 553190002447 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 553190002448 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 553190002449 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 553190002450 Walker A/P-loop; other site 553190002451 ATP binding site [chemical binding]; other site 553190002452 Q-loop/lid; other site 553190002453 ABC transporter signature motif; other site 553190002454 Walker B; other site 553190002455 D-loop; other site 553190002456 H-loop/switch region; other site 553190002457 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 553190002458 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 553190002459 Walker A/P-loop; other site 553190002460 ATP binding site [chemical binding]; other site 553190002461 Q-loop/lid; other site 553190002462 ABC transporter signature motif; other site 553190002463 Walker B; other site 553190002464 D-loop; other site 553190002465 H-loop/switch region; other site 553190002466 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 553190002467 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 553190002468 recombination factor protein RarA; Reviewed; Region: PRK13342 553190002469 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 553190002470 Walker A motif; other site 553190002471 ATP binding site [chemical binding]; other site 553190002472 Walker B motif; other site 553190002473 arginine finger; other site 553190002474 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 553190002475 DEAD-like helicases superfamily; Region: DEXDc; smart00487 553190002476 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 553190002477 ATP binding site [chemical binding]; other site 553190002478 putative Mg++ binding site [ion binding]; other site 553190002479 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 553190002480 nucleotide binding region [chemical binding]; other site 553190002481 ATP-binding site [chemical binding]; other site 553190002482 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 553190002483 bifunctional cytidylate kinase/GTPase Der; Reviewed; Region: PRK09518 553190002484 AAA domain; Region: AAA_17; pfam13207 553190002485 Cytidylate kinase; Region: Cytidylate_kin; pfam02224 553190002486 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 553190002487 G1 box; other site 553190002488 GTP/Mg2+ binding site [chemical binding]; other site 553190002489 Switch I region; other site 553190002490 G2 box; other site 553190002491 Switch II region; other site 553190002492 G3 box; other site 553190002493 G4 box; other site 553190002494 G5 box; other site 553190002495 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 553190002496 G1 box; other site 553190002497 GTP/Mg2+ binding site [chemical binding]; other site 553190002498 Switch I region; other site 553190002499 G2 box; other site 553190002500 G3 box; other site 553190002501 Switch II region; other site 553190002502 G4 box; other site 553190002503 G5 box; other site 553190002504 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 553190002505 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 553190002506 RNA binding surface [nucleotide binding]; other site 553190002507 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 553190002508 active site 553190002509 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 553190002510 amphipathic channel; other site 553190002511 Asn-Pro-Ala signature motifs; other site 553190002512 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 553190002513 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 553190002514 purine monophosphate binding site [chemical binding]; other site 553190002515 dimer interface [polypeptide binding]; other site 553190002516 putative catalytic residues [active] 553190002517 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 553190002518 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 553190002519 active site 553190002520 Preprotein translocase subunit; Region: YajC; cl00806 553190002521 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 553190002522 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 553190002523 Walker A motif; other site 553190002524 ATP binding site [chemical binding]; other site 553190002525 Walker B motif; other site 553190002526 arginine finger; other site 553190002527 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 553190002528 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 553190002529 RuvA N terminal domain; Region: RuvA_N; pfam01330 553190002530 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 553190002531 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 553190002532 active site 553190002533 putative DNA-binding cleft [nucleotide binding]; other site 553190002534 dimer interface [polypeptide binding]; other site 553190002535 hypothetical protein; Validated; Region: PRK00110 553190002536 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 553190002537 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 553190002538 thiS-thiF/thiG interaction site; other site 553190002539 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 553190002540 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 553190002541 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 553190002542 active site 553190002543 dimer interface [polypeptide binding]; other site 553190002544 motif 1; other site 553190002545 motif 2; other site 553190002546 motif 3; other site 553190002547 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 553190002548 anticodon binding site; other site 553190002549 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 553190002550 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 553190002551 ABC-ATPase subunit interface; other site 553190002552 dimer interface [polypeptide binding]; other site 553190002553 putative PBP binding regions; other site 553190002554 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 553190002555 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 553190002556 ABC-ATPase subunit interface; other site 553190002557 dimer interface [polypeptide binding]; other site 553190002558 putative PBP binding regions; other site 553190002559 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 553190002560 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 553190002561 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 553190002562 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 553190002563 intersubunit interface [polypeptide binding]; other site 553190002564 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 553190002565 putative substrate binding site [chemical binding]; other site 553190002566 putative ATP binding site [chemical binding]; other site 553190002567 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 553190002568 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 553190002569 motif II; other site 553190002570 Transcriptional regulator [Transcription]; Region: LysR; COG0583 553190002571 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 553190002572 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 553190002573 dimerization interface [polypeptide binding]; other site 553190002574 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 553190002575 coproporphyrinogen III oxidase; Validated; Region: PRK05628 553190002576 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 553190002577 FeS/SAM binding site; other site 553190002578 HemN C-terminal domain; Region: HemN_C; pfam06969 553190002579 GTP-binding protein LepA; Provisional; Region: PRK05433 553190002580 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 553190002581 G1 box; other site 553190002582 putative GEF interaction site [polypeptide binding]; other site 553190002583 GTP/Mg2+ binding site [chemical binding]; other site 553190002584 Switch I region; other site 553190002585 G2 box; other site 553190002586 G3 box; other site 553190002587 Switch II region; other site 553190002588 G4 box; other site 553190002589 G5 box; other site 553190002590 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 553190002591 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 553190002592 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 553190002593 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 553190002594 Predicted membrane protein [Function unknown]; Region: COG2860 553190002595 UPF0126 domain; Region: UPF0126; pfam03458 553190002596 UPF0126 domain; Region: UPF0126; pfam03458 553190002597 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 553190002598 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 553190002599 homodimer interface [polypeptide binding]; other site 553190002600 substrate-cofactor binding pocket; other site 553190002601 catalytic residue [active] 553190002602 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 553190002603 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 553190002604 5S rRNA interface [nucleotide binding]; other site 553190002605 CTC domain interface [polypeptide binding]; other site 553190002606 L16 interface [polypeptide binding]; other site 553190002607 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 553190002608 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 553190002609 acyl-activating enzyme (AAE) consensus motif; other site 553190002610 putative AMP binding site [chemical binding]; other site 553190002611 putative active site [active] 553190002612 putative CoA binding site [chemical binding]; other site 553190002613 GTPase Era; Reviewed; Region: era; PRK00089 553190002614 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 553190002615 G1 box; other site 553190002616 GTP/Mg2+ binding site [chemical binding]; other site 553190002617 Switch I region; other site 553190002618 G2 box; other site 553190002619 Switch II region; other site 553190002620 G3 box; other site 553190002621 G4 box; other site 553190002622 G5 box; other site 553190002623 KH domain; Region: KH_2; pfam07650 553190002624 FOG: CBS domain [General function prediction only]; Region: COG0517 553190002625 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 553190002626 Transporter associated domain; Region: CorC_HlyC; smart01091 553190002627 metal-binding heat shock protein; Provisional; Region: PRK00016 553190002628 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 553190002629 PhoH-like protein; Region: PhoH; pfam02562 553190002630 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 553190002631 nucleotide binding site/active site [active] 553190002632 HIT family signature motif; other site 553190002633 catalytic residue [active] 553190002634 RNA methyltransferase, RsmE family; Region: TIGR00046 553190002635 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 553190002636 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 553190002637 succinate dehydrogenase and fumarate reductase iron-sulfur protein; Region: dhsB; TIGR00384 553190002638 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 553190002639 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 553190002640 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 553190002641 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 553190002642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553190002643 H+ Antiporter protein; Region: 2A0121; TIGR00900 553190002644 putative substrate translocation pore; other site 553190002645 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 553190002646 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 553190002647 ABC transporter; Region: ABC_tran_2; pfam12848 553190002648 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 553190002649 Uncharacterized conserved protein [Function unknown]; Region: COG4983 553190002650 D5 N terminal like; Region: D5_N; smart00885 553190002651 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 553190002652 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 553190002653 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 553190002654 Phage capsid family; Region: Phage_capsid; pfam05065 553190002655 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 553190002656 Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770 553190002657 putative catalytic residues [active] 553190002658 catalytic nucleophile [active] 553190002659 Recombinase; Region: Recombinase; pfam07508 553190002660 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 553190002661 Domain of unknown function (DUF4200); Region: DUF4200; pfam13863 553190002662 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 553190002663 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 553190002664 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 553190002665 oligomer interface [polypeptide binding]; other site 553190002666 active site residues [active] 553190002667 Clp protease; Region: CLP_protease; pfam00574 553190002668 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 553190002669 oligomer interface [polypeptide binding]; other site 553190002670 active site residues [active] 553190002671 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 553190002672 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 553190002673 Cl- selectivity filter; other site 553190002674 Cl- binding residues [ion binding]; other site 553190002675 pore gating glutamate residue; other site 553190002676 dimer interface [polypeptide binding]; other site 553190002677 trigger factor; Provisional; Region: tig; PRK01490 553190002678 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 553190002679 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 553190002680 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 553190002681 active site 553190002682 catalytic site [active] 553190002683 substrate binding site [chemical binding]; other site 553190002684 HRDC domain; Region: HRDC; pfam00570 553190002685 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 553190002686 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 553190002687 FeS/SAM binding site; other site 553190002688 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 553190002689 Pyruvate formate lyase 1; Region: PFL1; cd01678 553190002690 coenzyme A binding site [chemical binding]; other site 553190002691 active site 553190002692 catalytic residues [active] 553190002693 glycine loop; other site 553190002694 NAD synthetase; Provisional; Region: PRK13981 553190002695 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 553190002696 multimer interface [polypeptide binding]; other site 553190002697 active site 553190002698 catalytic triad [active] 553190002699 protein interface 1 [polypeptide binding]; other site 553190002700 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 553190002701 homodimer interface [polypeptide binding]; other site 553190002702 NAD binding pocket [chemical binding]; other site 553190002703 ATP binding pocket [chemical binding]; other site 553190002704 Mg binding site [ion binding]; other site 553190002705 active-site loop [active] 553190002706 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 553190002707 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 553190002708 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 553190002709 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 553190002710 Walker A/P-loop; other site 553190002711 ATP binding site [chemical binding]; other site 553190002712 Q-loop/lid; other site 553190002713 ABC transporter signature motif; other site 553190002714 Walker B; other site 553190002715 D-loop; other site 553190002716 H-loop/switch region; other site 553190002717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553190002718 dimer interface [polypeptide binding]; other site 553190002719 conserved gate region; other site 553190002720 putative PBP binding loops; other site 553190002721 ABC-ATPase subunit interface; other site 553190002722 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 553190002723 thiamine phosphate binding site [chemical binding]; other site 553190002724 active site 553190002725 pyrophosphate binding site [ion binding]; other site 553190002726 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 553190002727 ThiC-associated domain; Region: ThiC-associated; pfam13667 553190002728 ThiC family; Region: ThiC; pfam01964 553190002729 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 553190002730 active site 553190002731 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 553190002732 active site 553190002733 phosphoserine phosphatase SerB; Region: serB; TIGR00338 553190002734 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 553190002735 motif II; other site 553190002736 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 553190002737 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 553190002738 putative active site [active] 553190002739 substrate binding site [chemical binding]; other site 553190002740 putative cosubstrate binding site; other site 553190002741 catalytic site [active] 553190002742 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 553190002743 substrate binding site [chemical binding]; other site 553190002744 chaperone protein DnaJ; Provisional; Region: PRK14278 553190002745 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 553190002746 HSP70 interaction site [polypeptide binding]; other site 553190002747 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 553190002748 Zn binding sites [ion binding]; other site 553190002749 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 553190002750 dimer interface [polypeptide binding]; other site 553190002751 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 553190002752 HTH domain; Region: HTH_11; pfam08279 553190002753 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 553190002754 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 553190002755 TPP-binding site [chemical binding]; other site 553190002756 dimer interface [polypeptide binding]; other site 553190002757 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 553190002758 PYR/PP interface [polypeptide binding]; other site 553190002759 dimer interface [polypeptide binding]; other site 553190002760 TPP binding site [chemical binding]; other site 553190002761 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 553190002762 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 553190002763 putative active site [active] 553190002764 transaldolase; Provisional; Region: PRK03903 553190002765 catalytic residue [active] 553190002766 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 553190002767 Divergent AAA domain; Region: AAA_4; pfam04326 553190002768 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 553190002769 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 553190002770 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 553190002771 active site 553190002772 motif I; other site 553190002773 motif II; other site 553190002774 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 553190002775 triosephosphate isomerase; Provisional; Region: PRK14567 553190002776 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 553190002777 substrate binding site [chemical binding]; other site 553190002778 dimer interface [polypeptide binding]; other site 553190002779 catalytic triad [active] 553190002780 Phosphoglycerate kinase; Region: PGK; pfam00162 553190002781 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 553190002782 substrate binding site [chemical binding]; other site 553190002783 hinge regions; other site 553190002784 ADP binding site [chemical binding]; other site 553190002785 catalytic site [active] 553190002786 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 553190002787 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 553190002788 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 553190002789 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 553190002790 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 553190002791 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 553190002792 NAD(P) binding site [chemical binding]; other site 553190002793 shikimate binding site; other site 553190002794 primosome assembly protein PriA; Provisional; Region: PRK14873 553190002795 S-adenosylmethionine synthetase; Validated; Region: PRK05250 553190002796 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 553190002797 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 553190002798 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 553190002799 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 553190002800 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 553190002801 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 553190002802 catalytic site [active] 553190002803 G-X2-G-X-G-K; other site 553190002804 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 553190002805 active site 553190002806 dimer interface [polypeptide binding]; other site 553190002807 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 553190002808 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 553190002809 ATP-grasp domain; Region: ATP-grasp_4; cl17255 553190002810 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 553190002811 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 553190002812 ATP-grasp domain; Region: ATP-grasp_4; cl17255 553190002813 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 553190002814 IMP binding site; other site 553190002815 dimer interface [polypeptide binding]; other site 553190002816 partial ornithine binding site; other site 553190002817 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 553190002818 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 553190002819 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 553190002820 catalytic site [active] 553190002821 subunit interface [polypeptide binding]; other site 553190002822 transcription antitermination factor NusB; Region: nusB; TIGR01951 553190002823 putative RNA binding site [nucleotide binding]; other site 553190002824 elongation factor P; Validated; Region: PRK00529 553190002825 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 553190002826 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 553190002827 RNA binding site [nucleotide binding]; other site 553190002828 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 553190002829 RNA binding site [nucleotide binding]; other site 553190002830 hypothetical protein; Provisional; Region: PRK11770 553190002831 Domain of unknown function (DUF307); Region: DUF307; pfam03733 553190002832 Domain of unknown function (DUF307); Region: DUF307; pfam03733 553190002833 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 553190002834 active site 553190002835 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 553190002836 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 553190002837 heterodimer interface [polypeptide binding]; other site 553190002838 active site 553190002839 FMN binding site [chemical binding]; other site 553190002840 homodimer interface [polypeptide binding]; other site 553190002841 substrate binding site [chemical binding]; other site 553190002842 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 553190002843 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 553190002844 FAD binding pocket [chemical binding]; other site 553190002845 FAD binding motif [chemical binding]; other site 553190002846 phosphate binding motif [ion binding]; other site 553190002847 beta-alpha-beta structure motif; other site 553190002848 NAD binding pocket [chemical binding]; other site 553190002849 Iron coordination center [ion binding]; other site 553190002850 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 553190002851 active site 553190002852 dimer interface [polypeptide binding]; other site 553190002853 dihydroorotase; Validated; Region: pyrC; PRK09357 553190002854 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 553190002855 active site 553190002856 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 553190002857 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 553190002858 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 553190002859 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 553190002860 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 553190002861 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 553190002862 metal binding triad; other site 553190002863 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 553190002864 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 553190002865 metal binding triad; other site 553190002866 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 553190002867 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 553190002868 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 553190002869 FAD binding site [chemical binding]; other site 553190002870 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 553190002871 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 553190002872 THF binding site; other site 553190002873 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 553190002874 substrate binding site [chemical binding]; other site 553190002875 THF binding site; other site 553190002876 zinc-binding site [ion binding]; other site 553190002877 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 553190002878 catalytic core [active] 553190002879 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 553190002880 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 553190002881 UGMP family protein; Validated; Region: PRK09604 553190002882 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 553190002883 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 553190002884 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 553190002885 Coenzyme A binding pocket [chemical binding]; other site 553190002886 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 553190002887 Glycoprotease family; Region: Peptidase_M22; pfam00814 553190002888 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 553190002889 hypothetical protein; Reviewed; Region: PRK07914 553190002890 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 553190002891 Competence protein; Region: Competence; pfam03772 553190002892 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 553190002893 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 553190002894 Helix-hairpin-helix motif; Region: HHH; pfam00633 553190002895 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 553190002896 DNA binding site [nucleotide binding] 553190002897 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 553190002898 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 553190002899 active site 553190002900 HIGH motif; other site 553190002901 nucleotide binding site [chemical binding]; other site 553190002902 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 553190002903 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 553190002904 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 553190002905 active site 553190002906 KMSKS motif; other site 553190002907 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 553190002908 tRNA binding surface [nucleotide binding]; other site 553190002909 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 553190002910 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 553190002911 Fructosamine kinase; Region: Fructosamin_kin; cl17579 553190002912 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 553190002913 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 553190002914 acyl-activating enzyme (AAE) consensus motif; other site 553190002915 putative AMP binding site [chemical binding]; other site 553190002916 putative active site [active] 553190002917 putative CoA binding site [chemical binding]; other site 553190002918 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 553190002919 Peptidase family M23; Region: Peptidase_M23; pfam01551 553190002920 lysine transporter; Provisional; Region: PRK10836 553190002921 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 553190002922 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 553190002923 active site 553190002924 catalytic residues [active] 553190002925 DNA binding site [nucleotide binding] 553190002926 Int/Topo IB signature motif; other site 553190002927 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 553190002928 non-specific DNA binding site [nucleotide binding]; other site 553190002929 salt bridge; other site 553190002930 sequence-specific DNA binding site [nucleotide binding]; other site 553190002931 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 553190002932 DivIVA domain; Region: DivI1A_domain; TIGR03544 553190002933 RecT family; Region: RecT; cl04285 553190002934 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 553190002935 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 553190002936 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 553190002937 Phage Terminase; Region: Terminase_1; pfam03354 553190002938 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 553190002939 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 553190002940 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 553190002941 tail fiber protein; Region: PHA00430 553190002942 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 553190002943 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 553190002944 active site 553190002945 Holin family; Region: Phage_holin_4; cl01989 553190002946 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 553190002947 EamA-like transporter family; Region: EamA; pfam00892 553190002948 EamA-like transporter family; Region: EamA; pfam00892 553190002949 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 553190002950 LytTr DNA-binding domain; Region: LytTR; pfam04397 553190002951 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 553190002952 catalytic core [active] 553190002953 Oligomerisation domain; Region: Oligomerisation; pfam02410 553190002954 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 553190002955 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 553190002956 Substrate binding site; other site 553190002957 Mg++ binding site; other site 553190002958 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 553190002959 active site 553190002960 substrate binding site [chemical binding]; other site 553190002961 CoA binding site [chemical binding]; other site 553190002962 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 553190002963 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 553190002964 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 553190002965 active site 553190002966 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 553190002967 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 553190002968 active site 553190002969 (T/H)XGH motif; other site 553190002970 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 553190002971 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 553190002972 putative catalytic cysteine [active] 553190002973 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 553190002974 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 553190002975 pyridoxal 5'-phosphate binding site [chemical binding]; other site 553190002976 catalytic residue [active] 553190002977 recombination regulator RecX; Reviewed; Region: recX; PRK00117 553190002978 recombinase A; Provisional; Region: recA; PRK09354 553190002979 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 553190002980 hexamer interface [polypeptide binding]; other site 553190002981 Walker A motif; other site 553190002982 ATP binding site [chemical binding]; other site 553190002983 Walker B motif; other site 553190002984 Competence-damaged protein; Region: CinA; pfam02464 553190002985 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 553190002986 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 553190002987 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 553190002988 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 553190002989 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 553190002990 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 553190002991 active site 553190002992 catalytic site [active] 553190002993 Cna protein B-type domain; Region: Cna_B; pfam05738 553190002994 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 553190002995 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 553190002996 ATP-grasp domain; Region: ATP-grasp; pfam02222 553190002997 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 553190002998 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 553190002999 ATP binding site [chemical binding]; other site 553190003000 active site 553190003001 substrate binding site [chemical binding]; other site 553190003002 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 553190003003 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 553190003004 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 553190003005 dimerization interface [polypeptide binding]; other site 553190003006 ATP binding site [chemical binding]; other site 553190003007 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 553190003008 dimerization interface [polypeptide binding]; other site 553190003009 ATP binding site [chemical binding]; other site 553190003010 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 553190003011 putative active site [active] 553190003012 catalytic triad [active] 553190003013 amidophosphoribosyltransferase; Provisional; Region: PRK07272 553190003014 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 553190003015 active site 553190003016 tetramer interface [polypeptide binding]; other site 553190003017 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 553190003018 active site 553190003019 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 553190003020 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 553190003021 dimerization interface [polypeptide binding]; other site 553190003022 putative ATP binding site [chemical binding]; other site 553190003023 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 553190003024 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 553190003025 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 553190003026 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 553190003027 Sulfatase; Region: Sulfatase; pfam00884 553190003028 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 553190003029 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 553190003030 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 553190003031 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 553190003032 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 553190003033 NAD binding site [chemical binding]; other site 553190003034 ATP-grasp domain; Region: ATP-grasp; pfam02222 553190003035 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 553190003036 metal binding site 2 [ion binding]; metal-binding site 553190003037 putative DNA binding helix; other site 553190003038 metal binding site 1 [ion binding]; metal-binding site 553190003039 dimer interface [polypeptide binding]; other site 553190003040 structural Zn2+ binding site [ion binding]; other site 553190003041 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 553190003042 transmembrane helices; other site 553190003043 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 553190003044 acetolactate synthase; Reviewed; Region: PRK08322 553190003045 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 553190003046 PYR/PP interface [polypeptide binding]; other site 553190003047 dimer interface [polypeptide binding]; other site 553190003048 TPP binding site [chemical binding]; other site 553190003049 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 553190003050 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 553190003051 TPP-binding site [chemical binding]; other site 553190003052 dimer interface [polypeptide binding]; other site 553190003053 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 553190003054 active site 553190003055 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 553190003056 Cobalt transport protein; Region: CbiQ; cl00463 553190003057 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 553190003058 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 553190003059 Walker A/P-loop; other site 553190003060 ATP binding site [chemical binding]; other site 553190003061 Q-loop/lid; other site 553190003062 ABC transporter signature motif; other site 553190003063 Walker B; other site 553190003064 D-loop; other site 553190003065 H-loop/switch region; other site 553190003066 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 553190003067 active site 553190003068 catalytic site [active] 553190003069 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 553190003070 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 553190003071 DNA primase; Validated; Region: dnaG; PRK05667 553190003072 CHC2 zinc finger; Region: zf-CHC2; pfam01807 553190003073 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 553190003074 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 553190003075 active site 553190003076 metal binding site [ion binding]; metal-binding site 553190003077 interdomain interaction site; other site 553190003078 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 553190003079 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 553190003080 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 553190003081 Zn2+ binding site [ion binding]; other site 553190003082 Mg2+ binding site [ion binding]; other site 553190003083 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 553190003084 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 553190003085 alanine racemase; Reviewed; Region: alr; PRK00053 553190003086 active site 553190003087 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 553190003088 dimer interface [polypeptide binding]; other site 553190003089 substrate binding site [chemical binding]; other site 553190003090 catalytic residues [active] 553190003091 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 553190003092 S-ribosylhomocysteinase; Provisional; Region: PRK02260 553190003093 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 553190003094 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 553190003095 Walker A/P-loop; other site 553190003096 ATP binding site [chemical binding]; other site 553190003097 Q-loop/lid; other site 553190003098 ABC transporter signature motif; other site 553190003099 Walker B; other site 553190003100 D-loop; other site 553190003101 H-loop/switch region; other site 553190003102 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 553190003103 Walker A/P-loop; other site 553190003104 ATP binding site [chemical binding]; other site 553190003105 Q-loop/lid; other site 553190003106 ABC transporter signature motif; other site 553190003107 Walker B; other site 553190003108 D-loop; other site 553190003109 H-loop/switch region; other site 553190003110 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 553190003111 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 553190003112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553190003113 dimer interface [polypeptide binding]; other site 553190003114 conserved gate region; other site 553190003115 putative PBP binding loops; other site 553190003116 ABC-ATPase subunit interface; other site 553190003117 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 553190003118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553190003119 dimer interface [polypeptide binding]; other site 553190003120 conserved gate region; other site 553190003121 putative PBP binding loops; other site 553190003122 ABC-ATPase subunit interface; other site 553190003123 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 553190003124 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 553190003125 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 553190003126 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 553190003127 active site 553190003128 multimer interface [polypeptide binding]; other site 553190003129 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 553190003130 predicted active site [active] 553190003131 catalytic triad [active] 553190003132 RelB antitoxin; Region: RelB; cl01171 553190003133 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 553190003134 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 553190003135 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 553190003136 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 553190003137 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 553190003138 pantothenate kinase; Reviewed; Region: PRK13318 553190003139 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 553190003140 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 553190003141 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 553190003142 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 553190003143 glutaminase active site [active] 553190003144 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 553190003145 dimer interface [polypeptide binding]; other site 553190003146 active site 553190003147 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 553190003148 dimer interface [polypeptide binding]; other site 553190003149 active site 553190003150 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 553190003151 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 553190003152 Walker A/P-loop; other site 553190003153 ATP binding site [chemical binding]; other site 553190003154 Q-loop/lid; other site 553190003155 ABC transporter signature motif; other site 553190003156 Walker B; other site 553190003157 D-loop; other site 553190003158 H-loop/switch region; other site 553190003159 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 553190003160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553190003161 dimer interface [polypeptide binding]; other site 553190003162 conserved gate region; other site 553190003163 putative PBP binding loops; other site 553190003164 ABC-ATPase subunit interface; other site 553190003165 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 553190003166 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 553190003167 substrate binding pocket [chemical binding]; other site 553190003168 membrane-bound complex binding site; other site 553190003169 hinge residues; other site 553190003170 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 553190003171 SmpB-tmRNA interface; other site 553190003172 CHAP domain; Region: CHAP; pfam05257 553190003173 Surface antigen [General function prediction only]; Region: COG3942 553190003174 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 553190003175 FtsX-like permease family; Region: FtsX; pfam02687 553190003176 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 553190003177 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553190003178 Walker A/P-loop; other site 553190003179 ATP binding site [chemical binding]; other site 553190003180 Q-loop/lid; other site 553190003181 ABC transporter signature motif; other site 553190003182 Walker B; other site 553190003183 D-loop; other site 553190003184 H-loop/switch region; other site 553190003185 peptide chain release factor 2; Validated; Region: prfB; PRK00578 553190003186 This domain is found in peptide chain release factors; Region: PCRF; smart00937 553190003187 RF-1 domain; Region: RF-1; pfam00472 553190003188 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 553190003189 active site 553190003190 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 553190003191 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 553190003192 active site 553190003193 Zn binding site [ion binding]; other site 553190003194 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 553190003195 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 553190003196 dimer interface [polypeptide binding]; other site 553190003197 ssDNA binding site [nucleotide binding]; other site 553190003198 tetramer (dimer of dimers) interface [polypeptide binding]; other site 553190003199 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 553190003200 prolyl-tRNA synthetase; Provisional; Region: PRK09194 553190003201 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 553190003202 dimer interface [polypeptide binding]; other site 553190003203 motif 1; other site 553190003204 active site 553190003205 motif 2; other site 553190003206 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 553190003207 putative deacylase active site [active] 553190003208 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 553190003209 active site 553190003210 motif 3; other site 553190003211 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 553190003212 anticodon binding site; other site 553190003213 AAA domain; Region: AAA_30; pfam13604 553190003214 PIF1-like helicase; Region: PIF1; pfam05970 553190003215 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 553190003216 catalytic site [active] 553190003217 putative active site [active] 553190003218 putative substrate binding site [chemical binding]; other site 553190003219 dimer interface [polypeptide binding]; other site 553190003220 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 553190003221 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 553190003222 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 553190003223 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 553190003224 active site 553190003225 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 553190003226 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 553190003227 Mg++ binding site [ion binding]; other site 553190003228 putative catalytic motif [active] 553190003229 substrate binding site [chemical binding]; other site 553190003230 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 553190003231 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 553190003232 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 553190003233 peptide chain release factor 1; Validated; Region: prfA; PRK00591 553190003234 PCRF domain; Region: PCRF; pfam03462 553190003235 RF-1 domain; Region: RF-1; pfam00472 553190003236 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 553190003237 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 553190003238 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 553190003239 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 553190003240 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 553190003241 synthetase active site [active] 553190003242 NTP binding site [chemical binding]; other site 553190003243 metal binding site [ion binding]; metal-binding site 553190003244 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 553190003245 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 553190003246 elongation factor Tu; Reviewed; Region: PRK00049 553190003247 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 553190003248 G1 box; other site 553190003249 GEF interaction site [polypeptide binding]; other site 553190003250 GTP/Mg2+ binding site [chemical binding]; other site 553190003251 Switch I region; other site 553190003252 G2 box; other site 553190003253 G3 box; other site 553190003254 Switch II region; other site 553190003255 G4 box; other site 553190003256 G5 box; other site 553190003257 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 553190003258 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 553190003259 Antibiotic Binding Site [chemical binding]; other site 553190003260 elongation factor G; Reviewed; Region: PRK00007 553190003261 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 553190003262 G1 box; other site 553190003263 putative GEF interaction site [polypeptide binding]; other site 553190003264 GTP/Mg2+ binding site [chemical binding]; other site 553190003265 Switch I region; other site 553190003266 G2 box; other site 553190003267 G3 box; other site 553190003268 Switch II region; other site 553190003269 G4 box; other site 553190003270 G5 box; other site 553190003271 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 553190003272 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 553190003273 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 553190003274 30S ribosomal protein S7; Validated; Region: PRK05302 553190003275 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 553190003276 S17 interaction site [polypeptide binding]; other site 553190003277 S8 interaction site; other site 553190003278 16S rRNA interaction site [nucleotide binding]; other site 553190003279 streptomycin interaction site [chemical binding]; other site 553190003280 23S rRNA interaction site [nucleotide binding]; other site 553190003281 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 553190003282 cell division protein FtsQ; Provisional; Region: PRK05529 553190003283 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 553190003284 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 553190003285 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 553190003286 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 553190003287 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 553190003288 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 553190003289 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 553190003290 active site 553190003291 homodimer interface [polypeptide binding]; other site 553190003292 cell division protein FtsW; Region: ftsW; TIGR02614 553190003293 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 553190003294 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 553190003295 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 553190003296 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 553190003297 Mg++ binding site [ion binding]; other site 553190003298 putative catalytic motif [active] 553190003299 putative substrate binding site [chemical binding]; other site 553190003300 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 553190003301 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 553190003302 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 553190003303 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 553190003304 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 553190003305 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 553190003306 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 553190003307 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 553190003308 MraW methylase family; Region: Methyltransf_5; cl17771 553190003309 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 553190003310 MraZ protein; Region: MraZ; pfam02381 553190003311 cell division protein MraZ; Reviewed; Region: PRK00326 553190003312 MraZ protein; Region: MraZ; pfam02381 553190003313 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 553190003314 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 553190003315 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 553190003316 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 553190003317 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 553190003318 active site 553190003319 PHP Thumb interface [polypeptide binding]; other site 553190003320 metal binding site [ion binding]; metal-binding site 553190003321 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 553190003322 generic binding surface II; other site 553190003323 generic binding surface I; other site 553190003324 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 553190003325 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 553190003326 active site 553190003327 lipoprotein signal peptidase; Provisional; Region: PRK14771 553190003328 DivIVA protein; Region: DivIVA; pfam05103 553190003329 DivIVA domain; Region: DivI1A_domain; TIGR03544 553190003330 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 553190003331 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 553190003332 NAD(P) binding site [chemical binding]; other site 553190003333 active site 553190003334 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 553190003335 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 553190003336 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 553190003337 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 553190003338 Walker A/P-loop; other site 553190003339 ATP binding site [chemical binding]; other site 553190003340 Q-loop/lid; other site 553190003341 ABC transporter signature motif; other site 553190003342 Walker B; other site 553190003343 D-loop; other site 553190003344 H-loop/switch region; other site 553190003345 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 553190003346 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 553190003347 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553190003348 Walker A/P-loop; other site 553190003349 ATP binding site [chemical binding]; other site 553190003350 Q-loop/lid; other site 553190003351 ABC transporter signature motif; other site 553190003352 Walker B; other site 553190003353 D-loop; other site 553190003354 H-loop/switch region; other site 553190003355 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 553190003356 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 553190003357 FeS/SAM binding site; other site 553190003358 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 553190003359 ATP cone domain; Region: ATP-cone; pfam03477 553190003360 Class III ribonucleotide reductase; Region: RNR_III; cd01675 553190003361 effector binding site; other site 553190003362 active site 553190003363 Zn binding site [ion binding]; other site 553190003364 glycine loop; other site 553190003365 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 553190003366 helicase 45; Provisional; Region: PTZ00424 553190003367 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 553190003368 ATP binding site [chemical binding]; other site 553190003369 putative Mg++ binding site [ion binding]; other site 553190003370 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 553190003371 nucleotide binding region [chemical binding]; other site 553190003372 ATP-binding site [chemical binding]; other site 553190003373 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 553190003374 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553190003375 Walker A/P-loop; other site 553190003376 ATP binding site [chemical binding]; other site 553190003377 Q-loop/lid; other site 553190003378 ABC transporter signature motif; other site 553190003379 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 553190003380 ABC transporter; Region: ABC_tran_2; pfam12848 553190003381 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 553190003382 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 553190003383 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 553190003384 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 553190003385 Walker A motif; other site 553190003386 ATP binding site [chemical binding]; other site 553190003387 Walker B motif; other site 553190003388 arginine finger; other site 553190003389 Peptidase family M41; Region: Peptidase_M41; pfam01434 553190003390 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 553190003391 active site 553190003392 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 553190003393 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 553190003394 Ligand Binding Site [chemical binding]; other site 553190003395 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 553190003396 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 553190003397 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 553190003398 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 553190003399 Walker A/P-loop; other site 553190003400 ATP binding site [chemical binding]; other site 553190003401 Q-loop/lid; other site 553190003402 ABC transporter signature motif; other site 553190003403 Walker B; other site 553190003404 D-loop; other site 553190003405 H-loop/switch region; other site 553190003406 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 553190003407 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 553190003408 DXD motif; other site 553190003409 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 553190003410 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 553190003411 Domain of unknown function DUF20; Region: UPF0118; pfam01594 553190003412 glutamine synthetase, type I; Region: GlnA; TIGR00653 553190003413 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 553190003414 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 553190003415 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 553190003416 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 553190003417 Walker A/P-loop; other site 553190003418 ATP binding site [chemical binding]; other site 553190003419 Q-loop/lid; other site 553190003420 ABC transporter signature motif; other site 553190003421 Walker B; other site 553190003422 D-loop; other site 553190003423 H-loop/switch region; other site 553190003424 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 553190003425 FtsX-like permease family; Region: FtsX; pfam02687 553190003426 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 553190003427 FtsX-like permease family; Region: FtsX; pfam02687 553190003428 Replication factor C C-terminal domain; Region: Rep_fac_C; pfam08542 553190003429 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 553190003430 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 553190003431 Double zinc ribbon; Region: DZR; pfam12773 553190003432 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 553190003433 active site 553190003434 catalytic residues [active] 553190003435 metal binding site [ion binding]; metal-binding site 553190003436 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 553190003437 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 553190003438 active site 553190003439 substrate binding site [chemical binding]; other site 553190003440 metal binding site [ion binding]; metal-binding site 553190003441 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 553190003442 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 553190003443 Zn binding site [ion binding]; other site 553190003444 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 553190003445 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 553190003446 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 553190003447 Major Facilitator Superfamily; Region: MFS_1; pfam07690 553190003448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553190003449 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 553190003450 Coenzyme A binding pocket [chemical binding]; other site 553190003451 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 553190003452 Part of AAA domain; Region: AAA_19; pfam13245 553190003453 Family description; Region: UvrD_C_2; pfam13538 553190003454 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 553190003455 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 553190003456 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 553190003457 substrate binding site [chemical binding]; other site 553190003458 multimerization interface [polypeptide binding]; other site 553190003459 ATP binding site [chemical binding]; other site 553190003460 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 553190003461 thiamine phosphate binding site [chemical binding]; other site 553190003462 active site 553190003463 pyrophosphate binding site [ion binding]; other site 553190003464 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 553190003465 dimer interface [polypeptide binding]; other site 553190003466 substrate binding site [chemical binding]; other site 553190003467 ATP binding site [chemical binding]; other site 553190003468 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 553190003469 active site 553190003470 catalytic site [active] 553190003471 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 553190003472 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 553190003473 salt bridge; other site 553190003474 non-specific DNA binding site [nucleotide binding]; other site 553190003475 sequence-specific DNA binding site [nucleotide binding]; other site 553190003476 ORF6N domain; Region: ORF6N; pfam10543 553190003477 RNA polymerase beta' subunit; Region: rpoC1; CHL00018 553190003478 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 553190003479 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 553190003480 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 553190003481 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 553190003482 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 553190003483 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 553190003484 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 553190003485 DNA binding site [nucleotide binding] 553190003486 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 553190003487 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 553190003488 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 553190003489 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 553190003490 RPB1 interaction site [polypeptide binding]; other site 553190003491 RPB10 interaction site [polypeptide binding]; other site 553190003492 RPB11 interaction site [polypeptide binding]; other site 553190003493 RPB3 interaction site [polypeptide binding]; other site 553190003494 RPB12 interaction site [polypeptide binding]; other site 553190003495 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 553190003496 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 553190003497 endonuclease III; Region: ENDO3c; smart00478 553190003498 minor groove reading motif; other site 553190003499 helix-hairpin-helix signature motif; other site 553190003500 substrate binding pocket [chemical binding]; other site 553190003501 active site 553190003502 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 553190003503 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 553190003504 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 553190003505 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 553190003506 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 553190003507 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 553190003508 active site 553190003509 EamA-like transporter family; Region: EamA; pfam00892 553190003510 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 553190003511 EamA-like transporter family; Region: EamA; pfam00892 553190003512 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 553190003513 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 553190003514 NAD binding site [chemical binding]; other site 553190003515 substrate binding site [chemical binding]; other site 553190003516 homodimer interface [polypeptide binding]; other site 553190003517 active site 553190003518 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 553190003519 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 553190003520 UDP-galactopyranose mutase; Region: GLF; pfam03275 553190003521 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 553190003522 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 553190003523 Probable Catalytic site; other site 553190003524 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 553190003525 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 553190003526 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 553190003527 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 553190003528 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 553190003529 Walker A/P-loop; other site 553190003530 ATP binding site [chemical binding]; other site 553190003531 Q-loop/lid; other site 553190003532 ABC transporter signature motif; other site 553190003533 Walker B; other site 553190003534 D-loop; other site 553190003535 H-loop/switch region; other site 553190003536 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 553190003537 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 553190003538 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 553190003539 Acyltransferase family; Region: Acyl_transf_3; pfam01757 553190003540 LicD family; Region: LicD; pfam04991 553190003541 Transcriptional regulators [Transcription]; Region: MarR; COG1846 553190003542 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 553190003543 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 553190003544 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 553190003545 active site 553190003546 metal-binding site 553190003547 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 553190003548 Phosphotransferase enzyme family; Region: APH; pfam01636 553190003549 active site 553190003550 ATP binding site [chemical binding]; other site 553190003551 substrate binding site [chemical binding]; other site 553190003552 dimer interface [polypeptide binding]; other site 553190003553 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 553190003554 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 553190003555 Ligand binding site; other site 553190003556 Putative Catalytic site; other site 553190003557 DXD motif; other site 553190003558 Bacitracin resistance protein BacA; Region: BacA; cl00858 553190003559 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 553190003560 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 553190003561 active site 553190003562 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 553190003563 Rib/alpha-like repeat; Region: Rib; cl07159 553190003564 Rib/alpha-like repeat; Region: Rib; cl07159 553190003565 Rib/alpha-like repeat; Region: Rib; pfam08428 553190003566 Rib/alpha-like repeat; Region: Rib; cl07159 553190003567 Rib/alpha-like repeat; Region: Rib; cl07159 553190003568 Rib/alpha-like repeat; Region: Rib; cl07159 553190003569 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 553190003570 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 553190003571 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 553190003572 phosphate binding site [ion binding]; other site 553190003573 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 553190003574 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 553190003575 active site 2 [active] 553190003576 active site 1 [active] 553190003577 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 553190003578 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 553190003579 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 553190003580 putative NAD(P) binding site [chemical binding]; other site 553190003581 active site 553190003582 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 553190003583 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 553190003584 active site 553190003585 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 553190003586 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 553190003587 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 553190003588 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 553190003589 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 553190003590 ATP-grasp domain; Region: ATP-grasp_4; cl17255 553190003591 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 553190003592 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 553190003593 carboxyltransferase (CT) interaction site; other site 553190003594 biotinylation site [posttranslational modification]; other site 553190003595 BioY family; Region: BioY; pfam02632 553190003596 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 553190003597 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 553190003598 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 553190003599 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 553190003600 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 553190003601 mRNA/rRNA interface [nucleotide binding]; other site 553190003602 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 553190003603 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 553190003604 L7/L12 interface [polypeptide binding]; other site 553190003605 23S rRNA interface [nucleotide binding]; other site 553190003606 L25 interface [polypeptide binding]; other site 553190003607 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 553190003608 ORF6N domain; Region: ORF6N; pfam10543 553190003609 AAA domain; Region: AAA_14; pfam13173 553190003610 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 553190003611 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 553190003612 active site 553190003613 catalytic site [active] 553190003614 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 553190003615 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 553190003616 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 553190003617 putative homodimer interface [polypeptide binding]; other site 553190003618 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 553190003619 heterodimer interface [polypeptide binding]; other site 553190003620 homodimer interface [polypeptide binding]; other site 553190003621 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 553190003622 aspartate aminotransferase; Provisional; Region: PRK05764 553190003623 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 553190003624 pyridoxal 5'-phosphate binding site [chemical binding]; other site 553190003625 homodimer interface [polypeptide binding]; other site 553190003626 catalytic residue [active] 553190003627 gamma-glutamyl kinase; Provisional; Region: PRK05429 553190003628 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 553190003629 nucleotide binding site [chemical binding]; other site 553190003630 homotetrameric interface [polypeptide binding]; other site 553190003631 putative phosphate binding site [ion binding]; other site 553190003632 putative allosteric binding site; other site 553190003633 PUA domain; Region: PUA; pfam01472 553190003634 GTPase CgtA; Reviewed; Region: obgE; PRK12296 553190003635 GTP1/OBG; Region: GTP1_OBG; pfam01018 553190003636 Obg GTPase; Region: Obg; cd01898 553190003637 G1 box; other site 553190003638 GTP/Mg2+ binding site [chemical binding]; other site 553190003639 Switch I region; other site 553190003640 G2 box; other site 553190003641 G3 box; other site 553190003642 Switch II region; other site 553190003643 G4 box; other site 553190003644 G5 box; other site 553190003645 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 553190003646 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 553190003647 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 553190003648 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 553190003649 homodimer interface [polypeptide binding]; other site 553190003650 oligonucleotide binding site [chemical binding]; other site 553190003651 Predicted permeases [General function prediction only]; Region: COG0679 553190003652 KilA-N domain; Region: KilA-N; pfam04383 553190003653 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 553190003654 putative active site [active] 553190003655 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 553190003656 dimer interface [polypeptide binding]; other site 553190003657 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 553190003658 nudix motif; other site 553190003659 homoserine kinase; Provisional; Region: PRK01212 553190003660 homoserine dehydrogenase; Provisional; Region: PRK06349 553190003661 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 553190003662 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 553190003663 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 553190003664 CAAX protease self-immunity; Region: Abi; pfam02517 553190003665 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 553190003666 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 553190003667 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 553190003668 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 553190003669 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 553190003670 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 553190003671 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 553190003672 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 553190003673 putative acyl-acceptor binding pocket; other site 553190003674 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 553190003675 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 553190003676 ABC-ATPase subunit interface; other site 553190003677 dimer interface [polypeptide binding]; other site 553190003678 putative PBP binding regions; other site 553190003679 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 553190003680 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 553190003681 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 553190003682 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 553190003683 intersubunit interface [polypeptide binding]; other site 553190003684 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 553190003685 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 553190003686 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 553190003687 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 553190003688 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 553190003689 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 553190003690 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 553190003691 Isochorismatase family; Region: Isochorismatase; pfam00857 553190003692 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 553190003693 catalytic triad [active] 553190003694 conserved cis-peptide bond; other site 553190003695 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 553190003696 Zn2+ binding site [ion binding]; other site 553190003697 Mg2+ binding site [ion binding]; other site 553190003698 K+ potassium transporter; Region: K_trans; pfam02705 553190003699 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 553190003700 active site 553190003701 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 553190003702 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 553190003703 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 553190003704 Walker A/P-loop; other site 553190003705 ATP binding site [chemical binding]; other site 553190003706 Q-loop/lid; other site 553190003707 ABC transporter signature motif; other site 553190003708 Walker B; other site 553190003709 D-loop; other site 553190003710 H-loop/switch region; other site 553190003711 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 553190003712 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 553190003713 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553190003714 Walker A/P-loop; other site 553190003715 ATP binding site [chemical binding]; other site 553190003716 Q-loop/lid; other site 553190003717 ABC transporter signature motif; other site 553190003718 Walker B; other site 553190003719 D-loop; other site 553190003720 H-loop/switch region; other site 553190003721 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 553190003722 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 553190003723 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 553190003724 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 553190003725 Walker A/P-loop; other site 553190003726 ATP binding site [chemical binding]; other site 553190003727 Q-loop/lid; other site 553190003728 ABC transporter signature motif; other site 553190003729 Walker B; other site 553190003730 D-loop; other site 553190003731 H-loop/switch region; other site 553190003732 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 553190003733 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 553190003734 Walker A/P-loop; other site 553190003735 ATP binding site [chemical binding]; other site 553190003736 Q-loop/lid; other site 553190003737 ABC transporter signature motif; other site 553190003738 Walker B; other site 553190003739 D-loop; other site 553190003740 H-loop/switch region; other site 553190003741 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 553190003742 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 553190003743 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553190003744 dimer interface [polypeptide binding]; other site 553190003745 conserved gate region; other site 553190003746 putative PBP binding loops; other site 553190003747 ABC-ATPase subunit interface; other site 553190003748 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 553190003749 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553190003750 putative PBP binding loops; other site 553190003751 dimer interface [polypeptide binding]; other site 553190003752 ABC-ATPase subunit interface; other site 553190003753 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 553190003754 trimer interface [polypeptide binding]; other site 553190003755 active site 553190003756 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 553190003757 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 553190003758 active site 553190003759 HIGH motif; other site 553190003760 KMSKS motif; other site 553190003761 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 553190003762 tRNA binding surface [nucleotide binding]; other site 553190003763 anticodon binding site; other site 553190003764 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 553190003765 Predicted methyltransferases [General function prediction only]; Region: COG0313 553190003766 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 553190003767 putative SAM binding site [chemical binding]; other site 553190003768 putative homodimer interface [polypeptide binding]; other site 553190003769 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 553190003770 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 553190003771 formate--tetrahydrofolate ligase; Provisional; Region: PRK13506 553190003772 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 553190003773 Peptidase family C69; Region: Peptidase_C69; pfam03577 553190003774 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 553190003775 substrate binding site [chemical binding]; other site 553190003776 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 553190003777 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 553190003778 active site 553190003779 P-loop; other site 553190003780 phosphorylation site [posttranslational modification] 553190003781 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 553190003782 active site 553190003783 phosphorylation site [posttranslational modification] 553190003784 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 553190003785 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 553190003786 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 553190003787 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 553190003788 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 553190003789 dimerization domain swap beta strand [polypeptide binding]; other site 553190003790 regulatory protein interface [polypeptide binding]; other site 553190003791 active site 553190003792 regulatory phosphorylation site [posttranslational modification]; other site 553190003793 Transcriptional regulators [Transcription]; Region: PurR; COG1609 553190003794 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 553190003795 DNA binding site [nucleotide binding] 553190003796 domain linker motif; other site 553190003797 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 553190003798 dimerization interface [polypeptide binding]; other site 553190003799 ligand binding site [chemical binding]; other site 553190003800 DNA polymerase III subunit delta'; Validated; Region: PRK07940 553190003801 DNA polymerase III subunit delta'; Validated; Region: PRK08485 553190003802 thymidylate kinase; Validated; Region: tmk; PRK00698 553190003803 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 553190003804 TMP-binding site; other site 553190003805 ATP-binding site [chemical binding]; other site 553190003806 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 553190003807 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 553190003808 active site 553190003809 interdomain interaction site; other site 553190003810 putative metal-binding site [ion binding]; other site 553190003811 nucleotide binding site [chemical binding]; other site 553190003812 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 553190003813 domain I; other site 553190003814 phosphate binding site [ion binding]; other site 553190003815 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 553190003816 domain II; other site 553190003817 domain III; other site 553190003818 nucleotide binding site [chemical binding]; other site 553190003819 DNA binding groove [nucleotide binding] 553190003820 catalytic site [active] 553190003821 domain IV; other site 553190003822 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 553190003823 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 553190003824 active site 553190003825 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 553190003826 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 553190003827 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 553190003828 Transglycosylase; Region: Transgly; pfam00912 553190003829 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 553190003830 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 553190003831 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 553190003832 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 553190003833 motif II; other site 553190003834 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 553190003835 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 553190003836 DNA binding residues [nucleotide binding] 553190003837 putative dimer interface [polypeptide binding]; other site 553190003838 chaperone protein DnaJ; Provisional; Region: PRK14299 553190003839 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 553190003840 HSP70 interaction site [polypeptide binding]; other site 553190003841 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 553190003842 substrate binding site [polypeptide binding]; other site 553190003843 dimer interface [polypeptide binding]; other site 553190003844 GrpE; Region: GrpE; pfam01025 553190003845 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 553190003846 dimer interface [polypeptide binding]; other site 553190003847 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 553190003848 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 553190003849 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 553190003850 nucleotide binding site [chemical binding]; other site 553190003851 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 553190003852 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 553190003853 ATP binding site [chemical binding]; other site 553190003854 substrate interface [chemical binding]; other site 553190003855 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 553190003856 ThiS interaction site; other site 553190003857 putative active site [active] 553190003858 tetramer interface [polypeptide binding]; other site 553190003859 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 553190003860 thiS-thiF/thiG interaction site; other site 553190003861 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 553190003862 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 553190003863 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 553190003864 putative active site [active] 553190003865 putative catalytic site [active] 553190003866 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 553190003867 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553190003868 dimer interface [polypeptide binding]; other site 553190003869 conserved gate region; other site 553190003870 putative PBP binding loops; other site 553190003871 ABC-ATPase subunit interface; other site 553190003872 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 553190003873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553190003874 dimer interface [polypeptide binding]; other site 553190003875 conserved gate region; other site 553190003876 putative PBP binding loops; other site 553190003877 ABC-ATPase subunit interface; other site 553190003878 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 553190003879 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 553190003880 Transcriptional regulators [Transcription]; Region: PurR; COG1609 553190003881 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 553190003882 DNA binding site [nucleotide binding] 553190003883 domain linker motif; other site 553190003884 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 553190003885 ligand binding site [chemical binding]; other site 553190003886 dimerization interface [polypeptide binding]; other site 553190003887 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 553190003888 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_2; cd11348 553190003889 active site 553190003890 catalytic site [active] 553190003891 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 553190003892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553190003893 dimer interface [polypeptide binding]; other site 553190003894 conserved gate region; other site 553190003895 putative PBP binding loops; other site 553190003896 ABC-ATPase subunit interface; other site 553190003897 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 553190003898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553190003899 dimer interface [polypeptide binding]; other site 553190003900 conserved gate region; other site 553190003901 putative PBP binding loops; other site 553190003902 ABC-ATPase subunit interface; other site 553190003903 pullulanase, type I; Region: pulA_typeI; TIGR02104 553190003904 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 553190003905 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 553190003906 Ca binding site [ion binding]; other site 553190003907 active site 553190003908 catalytic site [active] 553190003909 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 553190003910 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 553190003911 Protein of unknown function, DUF624; Region: DUF624; cl02369 553190003912 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 553190003913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553190003914 dimer interface [polypeptide binding]; other site 553190003915 conserved gate region; other site 553190003916 putative PBP binding loops; other site 553190003917 ABC-ATPase subunit interface; other site 553190003918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553190003919 dimer interface [polypeptide binding]; other site 553190003920 conserved gate region; other site 553190003921 putative PBP binding loops; other site 553190003922 ABC-ATPase subunit interface; other site 553190003923 Transcriptional regulators [Transcription]; Region: PurR; COG1609 553190003924 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 553190003925 DNA binding site [nucleotide binding] 553190003926 domain linker motif; other site 553190003927 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 553190003928 ligand binding site [chemical binding]; other site 553190003929 dimerization interface [polypeptide binding]; other site 553190003930 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 553190003931 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 553190003932 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 553190003933 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 553190003934 catalytic core [active] 553190003935 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 553190003936 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 553190003937 dimer interface [polypeptide binding]; other site 553190003938 FMN binding site [chemical binding]; other site 553190003939 NADPH bind site [chemical binding]; other site 553190003940 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 553190003941 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 553190003942 non-specific DNA binding site [nucleotide binding]; other site 553190003943 salt bridge; other site 553190003944 sequence-specific DNA binding site [nucleotide binding]; other site 553190003945 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 553190003946 pyridoxal 5'-phosphate binding site [chemical binding]; other site 553190003947 homodimer interface [polypeptide binding]; other site 553190003948 catalytic residue [active] 553190003949 Transcriptional regulators [Transcription]; Region: PurR; COG1609 553190003950 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 553190003951 DNA binding site [nucleotide binding] 553190003952 domain linker motif; other site 553190003953 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 553190003954 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 553190003955 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 553190003956 active site 553190003957 homodimer interface [polypeptide binding]; other site 553190003958 catalytic site [active] 553190003959 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 553190003960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553190003961 dimer interface [polypeptide binding]; other site 553190003962 conserved gate region; other site 553190003963 putative PBP binding loops; other site 553190003964 ABC-ATPase subunit interface; other site 553190003965 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 553190003966 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553190003967 dimer interface [polypeptide binding]; other site 553190003968 conserved gate region; other site 553190003969 putative PBP binding loops; other site 553190003970 ABC-ATPase subunit interface; other site 553190003971 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 553190003972 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 553190003973 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 553190003974 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 553190003975 active site 553190003976 catalytic site [active] 553190003977 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553190003978 putative substrate translocation pore; other site 553190003979 Major Facilitator Superfamily; Region: MFS_1; pfam07690 553190003980 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 553190003981 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 553190003982 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 553190003983 active site 553190003984 phosphorylation site [posttranslational modification] 553190003985 intermolecular recognition site; other site 553190003986 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 553190003987 DNA binding residues [nucleotide binding] 553190003988 dimerization interface [polypeptide binding]; other site 553190003989 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 553190003990 AAA domain; Region: AAA_14; pfam13173 553190003991 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 553190003992 FMN binding site [chemical binding]; other site 553190003993 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 553190003994 dimer interface [polypeptide binding]; other site 553190003995 NAD-dependent deacetylase; Provisional; Region: PRK00481 553190003996 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 553190003997 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 553190003998 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 553190003999 Ca binding site [ion binding]; other site 553190004000 active site 553190004001 catalytic site [active] 553190004002 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 553190004003 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 553190004004 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 553190004005 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 553190004006 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 553190004007 substrate binding site [chemical binding]; other site 553190004008 dimer interface [polypeptide binding]; other site 553190004009 ATP binding site [chemical binding]; other site 553190004010 D-ribose pyranase; Provisional; Region: PRK11797 553190004011 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 553190004012 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 553190004013 ligand binding site [chemical binding]; other site 553190004014 dimerization interface [polypeptide binding]; other site 553190004015 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 553190004016 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 553190004017 TM-ABC transporter signature motif; other site 553190004018 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 553190004019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553190004020 Walker A/P-loop; other site 553190004021 ATP binding site [chemical binding]; other site 553190004022 Q-loop/lid; other site 553190004023 ABC transporter signature motif; other site 553190004024 Walker B; other site 553190004025 D-loop; other site 553190004026 H-loop/switch region; other site 553190004027 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 553190004028 Transcriptional regulators [Transcription]; Region: PurR; COG1609 553190004029 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 553190004030 DNA binding site [nucleotide binding] 553190004031 domain linker motif; other site 553190004032 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 553190004033 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 553190004034 nucleoside/Zn binding site; other site 553190004035 dimer interface [polypeptide binding]; other site 553190004036 catalytic motif [active] 553190004037 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 553190004038 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 553190004039 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 553190004040 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 553190004041 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 553190004042 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 553190004043 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 553190004044 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 553190004045 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 553190004046 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 553190004047 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 553190004048 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 553190004049 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 553190004050 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 553190004051 motif II; other site 553190004052 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 553190004053 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 553190004054 trimer interface [polypeptide binding]; other site 553190004055 active site 553190004056 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 553190004057 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 553190004058 pyridoxal 5'-phosphate binding site [chemical binding]; other site 553190004059 catalytic residue [active] 553190004060 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398