-- dump date 20140619_100819 -- class Genbank::misc_feature -- table misc_feature_note -- id note 525284000001 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 525284000002 gamma subunit interface [polypeptide binding]; other site 525284000003 LBP interface [polypeptide binding]; other site 525284000004 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 525284000005 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 525284000006 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 525284000007 alpha subunit interaction interface [polypeptide binding]; other site 525284000008 Walker A motif; other site 525284000009 ATP binding site [chemical binding]; other site 525284000010 Walker B motif; other site 525284000011 inhibitor binding site; inhibition site 525284000012 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 525284000013 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 525284000014 core domain interface [polypeptide binding]; other site 525284000015 delta subunit interface [polypeptide binding]; other site 525284000016 epsilon subunit interface [polypeptide binding]; other site 525284000017 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 525284000018 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 525284000019 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 525284000020 beta subunit interaction interface [polypeptide binding]; other site 525284000021 Walker A motif; other site 525284000022 ATP binding site [chemical binding]; other site 525284000023 Walker B motif; other site 525284000024 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 525284000025 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 525284000026 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 525284000027 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 525284000028 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 525284000029 ATP synthase subunit C; Region: ATP-synt_C; cl00466 525284000030 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 525284000031 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 525284000032 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 525284000033 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 525284000034 active site 525284000035 DNA binding site [nucleotide binding] 525284000036 Int/Topo IB signature motif; other site 525284000037 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 525284000038 H+ Antiporter protein; Region: 2A0121; TIGR00900 525284000039 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 525284000040 dimer interface [polypeptide binding]; other site 525284000041 ssDNA binding site [nucleotide binding]; other site 525284000042 tetramer (dimer of dimers) interface [polypeptide binding]; other site 525284000043 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 525284000044 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525284000045 non-specific DNA binding site [nucleotide binding]; other site 525284000046 salt bridge; other site 525284000047 sequence-specific DNA binding site [nucleotide binding]; other site 525284000048 phytoene desaturase; Region: crtI_fam; TIGR02734 525284000049 H2-forming N(5),N(10)-methenyltetrahydromethanopterin dehydrogenase-related protein; Region: hmd_rel; TIGR01724 525284000050 Transposase, Mutator family; Region: Transposase_mut; pfam00872 525284000051 MULE transposase domain; Region: MULE; pfam10551 525284000052 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 525284000053 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 525284000054 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525284000055 binding surface 525284000056 TPR motif; other site 525284000057 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 525284000058 hypothetical protein; Provisional; Region: PRK03298 525284000059 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 525284000060 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 525284000061 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 525284000062 FtsX-like permease family; Region: FtsX; pfam02687 525284000063 FtsX-like permease family; Region: FtsX; pfam02687 525284000064 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 525284000065 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525284000066 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 525284000067 Walker A/P-loop; other site 525284000068 ATP binding site [chemical binding]; other site 525284000069 Q-loop/lid; other site 525284000070 ABC transporter signature motif; other site 525284000071 Walker B; other site 525284000072 D-loop; other site 525284000073 H-loop/switch region; other site 525284000074 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 525284000075 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 525284000076 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 525284000077 putative allosteric regulatory site; other site 525284000078 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 525284000079 aspartate kinase; Reviewed; Region: PRK06635 525284000080 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 525284000081 putative nucleotide binding site [chemical binding]; other site 525284000082 putative catalytic residues [active] 525284000083 putative Mg ion binding site [ion binding]; other site 525284000084 putative aspartate binding site [chemical binding]; other site 525284000085 recombination protein RecR; Reviewed; Region: recR; PRK00076 525284000086 RecR protein; Region: RecR; pfam02132 525284000087 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 525284000088 putative active site [active] 525284000089 putative metal-binding site [ion binding]; other site 525284000090 tetramer interface [polypeptide binding]; other site 525284000091 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 525284000092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525284000093 Walker A motif; other site 525284000094 ATP binding site [chemical binding]; other site 525284000095 Walker B motif; other site 525284000096 arginine finger; other site 525284000097 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 525284000098 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 525284000099 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 525284000100 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 525284000101 ATP binding site [chemical binding]; other site 525284000102 Walker A motif; other site 525284000103 hexamer interface [polypeptide binding]; other site 525284000104 Walker B motif; other site 525284000105 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 525284000106 AAA domain; Region: AAA_31; pfam13614 525284000107 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 525284000108 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 525284000109 Cl- selectivity filter; other site 525284000110 Cl- binding residues [ion binding]; other site 525284000111 pore gating glutamate residue; other site 525284000112 dimer interface [polypeptide binding]; other site 525284000113 H+/Cl- coupling transport residue; other site 525284000114 CrcB-like protein; Region: CRCB; pfam02537 525284000115 CrcB-like protein; Region: CRCB; pfam02537 525284000116 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 525284000117 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 525284000118 GDP-binding site [chemical binding]; other site 525284000119 ACT binding site; other site 525284000120 IMP binding site; other site 525284000121 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 525284000122 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 525284000123 active site 525284000124 intersubunit interface [polypeptide binding]; other site 525284000125 zinc binding site [ion binding]; other site 525284000126 Na+ binding site [ion binding]; other site 525284000127 Chorismate mutase type II; Region: CM_2; cl00693 525284000128 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 525284000129 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 525284000130 putative DNA binding site [nucleotide binding]; other site 525284000131 putative Zn2+ binding site [ion binding]; other site 525284000132 AsnC family; Region: AsnC_trans_reg; pfam01037 525284000133 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 525284000134 transcription termination factor Rho; Provisional; Region: PRK12608 525284000135 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 525284000136 RNA binding site [nucleotide binding]; other site 525284000137 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 525284000138 Walker A motif; other site 525284000139 ATP binding site [chemical binding]; other site 525284000140 Walker B motif; other site 525284000141 hypothetical protein; Provisional; Region: PRK07208 525284000142 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 525284000143 UDP-galactopyranose mutase; Region: GLF; pfam03275 525284000144 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 525284000145 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 525284000146 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 525284000147 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 525284000148 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 525284000149 GatB domain; Region: GatB_Yqey; pfam02637 525284000150 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 525284000151 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 525284000152 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 525284000153 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 525284000154 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 525284000155 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 525284000156 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 525284000157 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525284000158 Walker A/P-loop; other site 525284000159 ATP binding site [chemical binding]; other site 525284000160 Q-loop/lid; other site 525284000161 ABC transporter signature motif; other site 525284000162 Walker B; other site 525284000163 D-loop; other site 525284000164 H-loop/switch region; other site 525284000165 potential frameshift: common BLAST hit: gi|283782612|ref|YP_003373366.1| RNA methyltransferase, TrmH family 525284000166 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 525284000167 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 525284000168 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 525284000169 RmuC family; Region: RmuC; pfam02646 525284000170 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525284000171 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 525284000172 Walker A/P-loop; other site 525284000173 ATP binding site [chemical binding]; other site 525284000174 Q-loop/lid; other site 525284000175 ABC transporter signature motif; other site 525284000176 Walker B; other site 525284000177 D-loop; other site 525284000178 H-loop/switch region; other site 525284000179 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 525284000180 Clp amino terminal domain; Region: Clp_N; pfam02861 525284000181 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525284000182 Walker A motif; other site 525284000183 ATP binding site [chemical binding]; other site 525284000184 Walker B motif; other site 525284000185 arginine finger; other site 525284000186 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525284000187 Walker A motif; other site 525284000188 ATP binding site [chemical binding]; other site 525284000189 Walker B motif; other site 525284000190 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 525284000191 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 525284000192 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 525284000193 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 525284000194 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 525284000195 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 525284000196 catalytic residue [active] 525284000197 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 525284000198 active site 525284000199 HIGH motif; other site 525284000200 nucleotide binding site [chemical binding]; other site 525284000201 active site 525284000202 KMSKS motif; other site 525284000203 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 525284000204 amphipathic channel; other site 525284000205 Asn-Pro-Ala signature motifs; other site 525284000206 polyphosphate kinase; Provisional; Region: PRK05443 525284000207 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 525284000208 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 525284000209 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 525284000210 putative domain interface [polypeptide binding]; other site 525284000211 putative active site [active] 525284000212 catalytic site [active] 525284000213 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 525284000214 putative active site [active] 525284000215 catalytic site [active] 525284000216 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525284000217 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 525284000218 Walker A motif; other site 525284000219 ATP binding site [chemical binding]; other site 525284000220 Walker B motif; other site 525284000221 AAA ATPase domain; Region: AAA_15; pfam13175 525284000222 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525284000223 Walker B; other site 525284000224 D-loop; other site 525284000225 H-loop/switch region; other site 525284000226 RloB-like protein; Region: RloB; pfam13707 525284000227 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 525284000228 active site 525284000229 Ap6A binding site [chemical binding]; other site 525284000230 nudix motif; other site 525284000231 metal binding site [ion binding]; metal-binding site 525284000232 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 525284000233 catalytic core [active] 525284000234 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525284000235 active site 525284000236 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 525284000237 catalytic triad [active] 525284000238 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 525284000239 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 525284000240 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 525284000241 replicative DNA helicase; Region: DnaB; TIGR00665 525284000242 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 525284000243 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 525284000244 Walker A motif; other site 525284000245 ATP binding site [chemical binding]; other site 525284000246 Walker B motif; other site 525284000247 DNA binding loops [nucleotide binding] 525284000248 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 525284000249 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 525284000250 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 525284000251 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 525284000252 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 525284000253 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 525284000254 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 525284000255 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 525284000256 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 525284000257 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 525284000258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284000259 dimer interface [polypeptide binding]; other site 525284000260 conserved gate region; other site 525284000261 putative PBP binding loops; other site 525284000262 ABC-ATPase subunit interface; other site 525284000263 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 525284000264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284000265 dimer interface [polypeptide binding]; other site 525284000266 conserved gate region; other site 525284000267 putative PBP binding loops; other site 525284000268 ABC-ATPase subunit interface; other site 525284000269 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 525284000270 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 525284000271 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 525284000272 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 525284000273 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 525284000274 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 525284000275 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 525284000276 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 525284000277 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 525284000278 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 525284000279 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 525284000280 Walker A/P-loop; other site 525284000281 ATP binding site [chemical binding]; other site 525284000282 Q-loop/lid; other site 525284000283 ABC transporter signature motif; other site 525284000284 Walker B; other site 525284000285 D-loop; other site 525284000286 H-loop/switch region; other site 525284000287 TOBE domain; Region: TOBE_2; pfam08402 525284000288 Protein kinase domain; Region: Pkinase; pfam00069 525284000289 Catalytic domain of Protein Kinases; Region: PKc; cd00180 525284000290 active site 525284000291 ATP binding site [chemical binding]; other site 525284000292 substrate binding site [chemical binding]; other site 525284000293 activation loop (A-loop); other site 525284000294 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 525284000295 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 525284000296 catalytic residues [active] 525284000297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 525284000298 Domain of unknown function (DUF348); Region: DUF348; pfam03990 525284000299 G5 domain; Region: G5; pfam07501 525284000300 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 525284000301 N-acetyl-D-glucosamine binding site [chemical binding]; other site 525284000302 catalytic residue [active] 525284000303 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 525284000304 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 525284000305 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 525284000306 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 525284000307 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 525284000308 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 525284000309 active site 525284000310 NTP binding site [chemical binding]; other site 525284000311 metal binding triad [ion binding]; metal-binding site 525284000312 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 525284000313 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525284000314 Zn2+ binding site [ion binding]; other site 525284000315 Mg2+ binding site [ion binding]; other site 525284000316 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 525284000317 active site 525284000318 Ap6A binding site [chemical binding]; other site 525284000319 nudix motif; other site 525284000320 metal binding site [ion binding]; metal-binding site 525284000321 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 525284000322 MviN-like protein; Region: MVIN; pfam03023 525284000323 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 525284000324 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 525284000325 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 525284000326 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 525284000327 ParB-like nuclease domain; Region: ParB; smart00470 525284000328 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 525284000329 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 525284000330 P-loop; other site 525284000331 Magnesium ion binding site [ion binding]; other site 525284000332 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 525284000333 Magnesium ion binding site [ion binding]; other site 525284000334 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 525284000335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525284000336 S-adenosylmethionine binding site [chemical binding]; other site 525284000337 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 525284000338 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 525284000339 G-X-X-G motif; other site 525284000340 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 525284000341 RxxxH motif; other site 525284000342 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 525284000343 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 525284000344 Ribonuclease P; Region: Ribonuclease_P; pfam00825 525284000345 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 525284000346 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525284000347 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 525284000348 Walker A motif; other site 525284000349 ATP binding site [chemical binding]; other site 525284000350 Walker B motif; other site 525284000351 arginine finger; other site 525284000352 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 525284000353 DnaA box-binding interface [nucleotide binding]; other site 525284000354 DNA polymerase III subunit beta; Validated; Region: PRK07761 525284000355 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 525284000356 putative DNA binding surface [nucleotide binding]; other site 525284000357 dimer interface [polypeptide binding]; other site 525284000358 beta-clamp/clamp loader binding surface; other site 525284000359 beta-clamp/translesion DNA polymerase binding surface; other site 525284000360 recombination protein F; Reviewed; Region: recF; PRK00064 525284000361 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525284000362 Walker A/P-loop; other site 525284000363 ATP binding site [chemical binding]; other site 525284000364 Q-loop/lid; other site 525284000365 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525284000366 ABC transporter signature motif; other site 525284000367 Walker B; other site 525284000368 D-loop; other site 525284000369 H-loop/switch region; other site 525284000370 Protein of unknown function (DUF721); Region: DUF721; pfam05258 525284000371 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 525284000372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525284000373 Mg2+ binding site [ion binding]; other site 525284000374 G-X-G motif; other site 525284000375 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 525284000376 anchoring element; other site 525284000377 dimer interface [polypeptide binding]; other site 525284000378 ATP binding site [chemical binding]; other site 525284000379 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 525284000380 active site 525284000381 putative metal-binding site [ion binding]; other site 525284000382 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 525284000383 DNA gyrase subunit A; Validated; Region: PRK05560 525284000384 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 525284000385 CAP-like domain; other site 525284000386 active site 525284000387 primary dimer interface [polypeptide binding]; other site 525284000388 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 525284000389 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 525284000390 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 525284000391 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 525284000392 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 525284000393 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 525284000394 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 525284000395 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 525284000396 active site 525284000397 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 525284000398 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 525284000399 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 525284000400 phosphopeptide binding site; other site 525284000401 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 525284000402 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 525284000403 phosphopeptide binding site; other site 525284000404 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 525284000405 active site 525284000406 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 525284000407 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 525284000408 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 525284000409 potential frameshift: common BLAST hit: gi|283782548|ref|YP_003373302.1| kinase domain protein 525284000410 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 525284000411 active site 525284000412 ATP binding site [chemical binding]; other site 525284000413 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 525284000414 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 525284000415 substrate binding site [chemical binding]; other site 525284000416 activation loop (A-loop); other site 525284000417 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 525284000418 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 525284000419 active site 525284000420 ATP binding site [chemical binding]; other site 525284000421 substrate binding site [chemical binding]; other site 525284000422 activation loop (A-loop); other site 525284000423 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 525284000424 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 525284000425 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 525284000426 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 525284000427 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 525284000428 active site 525284000429 catalytic site [active] 525284000430 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 525284000431 putative septation inhibitor protein; Reviewed; Region: PRK02251 525284000432 Rhomboid family; Region: Rhomboid; pfam01694 525284000433 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 525284000434 homodimer interface [polypeptide binding]; other site 525284000435 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 525284000436 active site pocket [active] 525284000437 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 525284000438 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 525284000439 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 525284000440 active site 525284000441 HIGH motif; other site 525284000442 dimer interface [polypeptide binding]; other site 525284000443 KMSKS motif; other site 525284000444 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 525284000445 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 525284000446 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 525284000447 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 525284000448 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 525284000449 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 525284000450 active site clefts [active] 525284000451 zinc binding site [ion binding]; other site 525284000452 dimer interface [polypeptide binding]; other site 525284000453 Predicted permease; Region: DUF318; cl17795 525284000454 TIGR03943 family protein; Region: TIGR03943 525284000455 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 525284000456 Domain of unknown function DUF21; Region: DUF21; pfam01595 525284000457 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 525284000458 Transporter associated domain; Region: CorC_HlyC; smart01091 525284000459 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 525284000460 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 525284000461 dimerization interface [polypeptide binding]; other site 525284000462 DPS ferroxidase diiron center [ion binding]; other site 525284000463 ion pore; other site 525284000464 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 525284000465 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 525284000466 ferredoxin-NADP+ reductase; Region: PLN02852 525284000467 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 525284000468 Peptidase family M48; Region: Peptidase_M48; cl12018 525284000469 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 525284000470 Helix-turn-helix domain; Region: HTH_17; pfam12728 525284000471 Fic family protein [Function unknown]; Region: COG3177 525284000472 Fic/DOC family; Region: Fic; pfam02661 525284000473 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 525284000474 AAA domain; Region: AAA_14; pfam13173 525284000475 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 525284000476 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 525284000477 nucleophilic elbow; other site 525284000478 catalytic triad; other site 525284000479 Runt domain; Region: Runt; pfam00853 525284000480 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 525284000481 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 525284000482 nucleotide binding site [chemical binding]; other site 525284000483 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 525284000484 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 525284000485 putative active site cavity [active] 525284000486 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 525284000487 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 525284000488 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 525284000489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284000490 dimer interface [polypeptide binding]; other site 525284000491 conserved gate region; other site 525284000492 putative PBP binding loops; other site 525284000493 ABC-ATPase subunit interface; other site 525284000494 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 525284000495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284000496 dimer interface [polypeptide binding]; other site 525284000497 conserved gate region; other site 525284000498 putative PBP binding loops; other site 525284000499 ABC-ATPase subunit interface; other site 525284000500 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 525284000501 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 525284000502 Walker A/P-loop; other site 525284000503 ATP binding site [chemical binding]; other site 525284000504 Q-loop/lid; other site 525284000505 ABC transporter signature motif; other site 525284000506 Walker B; other site 525284000507 D-loop; other site 525284000508 H-loop/switch region; other site 525284000509 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 525284000510 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 525284000511 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 525284000512 Walker A/P-loop; other site 525284000513 ATP binding site [chemical binding]; other site 525284000514 Q-loop/lid; other site 525284000515 ABC transporter signature motif; other site 525284000516 Walker B; other site 525284000517 D-loop; other site 525284000518 H-loop/switch region; other site 525284000519 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 525284000520 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 525284000521 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 525284000522 inhibitor site; inhibition site 525284000523 active site 525284000524 dimer interface [polypeptide binding]; other site 525284000525 catalytic residue [active] 525284000526 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 525284000527 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 525284000528 active site 525284000529 trimer interface [polypeptide binding]; other site 525284000530 allosteric site; other site 525284000531 active site lid [active] 525284000532 hexamer (dimer of trimers) interface [polypeptide binding]; other site 525284000533 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 525284000534 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 525284000535 active site 525284000536 dimer interface [polypeptide binding]; other site 525284000537 Transcriptional regulators [Transcription]; Region: FadR; COG2186 525284000538 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 525284000539 DNA-binding site [nucleotide binding]; DNA binding site 525284000540 FCD domain; Region: FCD; pfam07729 525284000541 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 525284000542 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 525284000543 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 525284000544 Asp-box motif; other site 525284000545 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 525284000546 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 525284000547 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 525284000548 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 525284000549 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 525284000550 FMN binding site [chemical binding]; other site 525284000551 dimer interface [polypeptide binding]; other site 525284000552 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 525284000553 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 525284000554 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 525284000555 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 525284000556 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 525284000557 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 525284000558 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 525284000559 Soluble P-type ATPase [General function prediction only]; Region: COG4087 525284000560 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 525284000561 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 525284000562 trimer interface [polypeptide binding]; other site 525284000563 active site 525284000564 Predicted esterase [General function prediction only]; Region: COG0400 525284000565 Serine hydrolase (FSH1); Region: FSH1; pfam03959 525284000566 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 525284000567 nucleoside/Zn binding site; other site 525284000568 dimer interface [polypeptide binding]; other site 525284000569 catalytic motif [active] 525284000570 Transcriptional regulators [Transcription]; Region: PurR; COG1609 525284000571 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 525284000572 DNA binding site [nucleotide binding] 525284000573 domain linker motif; other site 525284000574 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 525284000575 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 525284000576 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 525284000577 Walker A/P-loop; other site 525284000578 ATP binding site [chemical binding]; other site 525284000579 Q-loop/lid; other site 525284000580 ABC transporter signature motif; other site 525284000581 Walker B; other site 525284000582 D-loop; other site 525284000583 H-loop/switch region; other site 525284000584 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 525284000585 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 525284000586 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 525284000587 TM-ABC transporter signature motif; other site 525284000588 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 525284000589 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 525284000590 ligand binding site [chemical binding]; other site 525284000591 dimerization interface [polypeptide binding]; other site 525284000592 D-ribose pyranase; Provisional; Region: PRK11797 525284000593 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 525284000594 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 525284000595 substrate binding site [chemical binding]; other site 525284000596 dimer interface [polypeptide binding]; other site 525284000597 ATP binding site [chemical binding]; other site 525284000598 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 525284000599 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 525284000600 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 525284000601 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 525284000602 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 525284000603 Ca binding site [ion binding]; other site 525284000604 active site 525284000605 catalytic site [active] 525284000606 NAD-dependent deacetylase; Provisional; Region: PRK00481 525284000607 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 525284000608 NAD+ binding site [chemical binding]; other site 525284000609 substrate binding site [chemical binding]; other site 525284000610 Zn binding site [ion binding]; other site 525284000611 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 525284000612 substrate binding site [chemical binding]; other site 525284000613 multimerization interface [polypeptide binding]; other site 525284000614 ATP binding site [chemical binding]; other site 525284000615 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 525284000616 thiamine phosphate binding site [chemical binding]; other site 525284000617 active site 525284000618 pyrophosphate binding site [ion binding]; other site 525284000619 multifunctional hydroxymethylpyrimidine phosphokinase/4-amino-5-aminomethyl-2-methylpyrimidine hydrolase; Provisional; Region: PRK14713 525284000620 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 525284000621 dimer interface [polypeptide binding]; other site 525284000622 substrate binding site [chemical binding]; other site 525284000623 ATP binding site [chemical binding]; other site 525284000624 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 525284000625 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 525284000626 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 525284000627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525284000628 active site 525284000629 phosphorylation site [posttranslational modification] 525284000630 intermolecular recognition site; other site 525284000631 dimerization interface [polypeptide binding]; other site 525284000632 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 525284000633 DNA binding residues [nucleotide binding] 525284000634 dimerization interface [polypeptide binding]; other site 525284000635 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 525284000636 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525284000637 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 525284000638 Walker A/P-loop; other site 525284000639 ATP binding site [chemical binding]; other site 525284000640 Q-loop/lid; other site 525284000641 ABC transporter signature motif; other site 525284000642 Walker B; other site 525284000643 D-loop; other site 525284000644 H-loop/switch region; other site 525284000645 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 525284000646 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 525284000647 FtsX-like permease family; Region: FtsX; pfam02687 525284000648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525284000649 putative substrate translocation pore; other site 525284000650 Major Facilitator Superfamily; Region: MFS_1; pfam07690 525284000651 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 525284000652 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 525284000653 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 525284000654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284000655 dimer interface [polypeptide binding]; other site 525284000656 conserved gate region; other site 525284000657 putative PBP binding loops; other site 525284000658 ABC-ATPase subunit interface; other site 525284000659 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 525284000660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284000661 dimer interface [polypeptide binding]; other site 525284000662 conserved gate region; other site 525284000663 putative PBP binding loops; other site 525284000664 ABC-ATPase subunit interface; other site 525284000665 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 525284000666 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 525284000667 active site 525284000668 homodimer interface [polypeptide binding]; other site 525284000669 catalytic site [active] 525284000670 Transcriptional regulators [Transcription]; Region: PurR; COG1609 525284000671 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 525284000672 DNA binding site [nucleotide binding] 525284000673 domain linker motif; other site 525284000674 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 525284000675 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 525284000676 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525284000677 non-specific DNA binding site [nucleotide binding]; other site 525284000678 salt bridge; other site 525284000679 sequence-specific DNA binding site [nucleotide binding]; other site 525284000680 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 525284000681 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525284000682 homodimer interface [polypeptide binding]; other site 525284000683 catalytic residue [active] 525284000684 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 525284000685 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 525284000686 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 525284000687 dimer interface [polypeptide binding]; other site 525284000688 FMN binding site [chemical binding]; other site 525284000689 NADPH bind site [chemical binding]; other site 525284000690 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 525284000691 catalytic core [active] 525284000692 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 525284000693 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 525284000694 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 525284000695 Transcriptional regulators [Transcription]; Region: PurR; COG1609 525284000696 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 525284000697 DNA binding site [nucleotide binding] 525284000698 domain linker motif; other site 525284000699 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 525284000700 ligand binding site [chemical binding]; other site 525284000701 dimerization interface [polypeptide binding]; other site 525284000702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284000703 dimer interface [polypeptide binding]; other site 525284000704 conserved gate region; other site 525284000705 putative PBP binding loops; other site 525284000706 ABC-ATPase subunit interface; other site 525284000707 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 525284000708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284000709 dimer interface [polypeptide binding]; other site 525284000710 conserved gate region; other site 525284000711 putative PBP binding loops; other site 525284000712 ABC-ATPase subunit interface; other site 525284000713 Protein of unknown function, DUF624; Region: DUF624; pfam04854 525284000714 Protein of unknown function, DUF624; Region: DUF624; cl02369 525284000715 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 525284000716 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 525284000717 endonuclease subunit; Provisional; Region: 46; PHA02562 525284000718 V-type ATP synthase subunit I; Validated; Region: PRK05771 525284000719 pullulanase, type I; Region: pulA_typeI; TIGR02104 525284000720 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 525284000721 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 525284000722 Ca binding site [ion binding]; other site 525284000723 active site 525284000724 catalytic site [active] 525284000725 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 525284000726 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284000727 dimer interface [polypeptide binding]; other site 525284000728 conserved gate region; other site 525284000729 putative PBP binding loops; other site 525284000730 ABC-ATPase subunit interface; other site 525284000731 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 525284000732 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284000733 dimer interface [polypeptide binding]; other site 525284000734 conserved gate region; other site 525284000735 putative PBP binding loops; other site 525284000736 ABC-ATPase subunit interface; other site 525284000737 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 525284000738 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 525284000739 trehalose synthase; Region: treS_nterm; TIGR02456 525284000740 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_2; cd11348 525284000741 active site 525284000742 catalytic site [active] 525284000743 Transcriptional regulators [Transcription]; Region: PurR; COG1609 525284000744 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 525284000745 DNA binding site [nucleotide binding] 525284000746 domain linker motif; other site 525284000747 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 525284000748 ligand binding site [chemical binding]; other site 525284000749 dimerization interface [polypeptide binding]; other site 525284000750 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 525284000751 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 525284000752 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284000753 dimer interface [polypeptide binding]; other site 525284000754 conserved gate region; other site 525284000755 putative PBP binding loops; other site 525284000756 ABC-ATPase subunit interface; other site 525284000757 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 525284000758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284000759 dimer interface [polypeptide binding]; other site 525284000760 conserved gate region; other site 525284000761 putative PBP binding loops; other site 525284000762 ABC-ATPase subunit interface; other site 525284000763 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 525284000764 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 525284000765 putative active site [active] 525284000766 putative catalytic site [active] 525284000767 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 525284000768 MAEBL; Provisional; Region: PTZ00121 525284000769 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 525284000770 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 525284000771 thiS-thiF/thiG interaction site; other site 525284000772 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 525284000773 ThiS interaction site; other site 525284000774 putative active site [active] 525284000775 tetramer interface [polypeptide binding]; other site 525284000776 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 525284000777 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 525284000778 ATP binding site [chemical binding]; other site 525284000779 substrate interface [chemical binding]; other site 525284000780 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 525284000781 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 525284000782 nucleotide binding site [chemical binding]; other site 525284000783 NEF interaction site [polypeptide binding]; other site 525284000784 SBD interface [polypeptide binding]; other site 525284000785 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 525284000786 dimer interface [polypeptide binding]; other site 525284000787 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 525284000788 chaperone protein DnaJ; Provisional; Region: PRK14286 525284000789 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 525284000790 HSP70 interaction site [polypeptide binding]; other site 525284000791 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 525284000792 substrate binding site [polypeptide binding]; other site 525284000793 dimer interface [polypeptide binding]; other site 525284000794 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 525284000795 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 525284000796 DNA binding residues [nucleotide binding] 525284000797 putative dimer interface [polypeptide binding]; other site 525284000798 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 525284000799 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 525284000800 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525284000801 motif II; other site 525284000802 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 525284000803 Transglycosylase; Region: Transgly; pfam00912 525284000804 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 525284000805 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 525284000806 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 525284000807 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 525284000808 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 525284000809 active site 525284000810 interdomain interaction site; other site 525284000811 putative metal-binding site [ion binding]; other site 525284000812 nucleotide binding site [chemical binding]; other site 525284000813 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 525284000814 domain I; other site 525284000815 DNA binding groove [nucleotide binding] 525284000816 phosphate binding site [ion binding]; other site 525284000817 domain II; other site 525284000818 domain III; other site 525284000819 nucleotide binding site [chemical binding]; other site 525284000820 catalytic site [active] 525284000821 domain IV; other site 525284000822 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 525284000823 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 525284000824 thymidylate kinase; Validated; Region: tmk; PRK00698 525284000825 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 525284000826 TMP-binding site; other site 525284000827 ATP-binding site [chemical binding]; other site 525284000828 DNA polymerase III subunit delta'; Validated; Region: PRK07940 525284000829 DNA polymerase III subunit delta'; Validated; Region: PRK08485 525284000830 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 525284000831 substrate binding site [chemical binding]; other site 525284000832 Peptidase family C69; Region: Peptidase_C69; pfam03577 525284000833 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 525284000834 Cna protein B-type domain; Region: Cna_B; pfam05738 525284000835 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 525284000836 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 525284000837 Predicted methyltransferases [General function prediction only]; Region: COG0313 525284000838 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 525284000839 putative SAM binding site [chemical binding]; other site 525284000840 putative homodimer interface [polypeptide binding]; other site 525284000841 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 525284000842 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 525284000843 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 525284000844 active site 525284000845 HIGH motif; other site 525284000846 KMSKS motif; other site 525284000847 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 525284000848 tRNA binding surface [nucleotide binding]; other site 525284000849 anticodon binding site; other site 525284000850 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 525284000851 trimer interface [polypeptide binding]; other site 525284000852 active site 525284000853 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 525284000854 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284000855 dimer interface [polypeptide binding]; other site 525284000856 conserved gate region; other site 525284000857 putative PBP binding loops; other site 525284000858 ABC-ATPase subunit interface; other site 525284000859 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 525284000860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284000861 dimer interface [polypeptide binding]; other site 525284000862 conserved gate region; other site 525284000863 putative PBP binding loops; other site 525284000864 ABC-ATPase subunit interface; other site 525284000865 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 525284000866 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 525284000867 Walker A/P-loop; other site 525284000868 ATP binding site [chemical binding]; other site 525284000869 Q-loop/lid; other site 525284000870 ABC transporter signature motif; other site 525284000871 Walker B; other site 525284000872 D-loop; other site 525284000873 H-loop/switch region; other site 525284000874 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 525284000875 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 525284000876 Walker A/P-loop; other site 525284000877 ATP binding site [chemical binding]; other site 525284000878 Q-loop/lid; other site 525284000879 ABC transporter signature motif; other site 525284000880 Walker B; other site 525284000881 D-loop; other site 525284000882 H-loop/switch region; other site 525284000883 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 525284000884 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 525284000885 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 525284000886 potential frameshift: common BLAST hit: gi|283783686|ref|YP_003374440.1| ABC transporter, ATP-binding protein 525284000887 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525284000888 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 525284000889 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 525284000890 Walker A/P-loop; other site 525284000891 ATP binding site [chemical binding]; other site 525284000892 Q-loop/lid; other site 525284000893 ABC transporter signature motif; other site 525284000894 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525284000895 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525284000896 ABC transporter signature motif; other site 525284000897 Walker B; other site 525284000898 D-loop; other site 525284000899 H-loop/switch region; other site 525284000900 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525284000901 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 525284000902 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 525284000903 Walker A/P-loop; other site 525284000904 ATP binding site [chemical binding]; other site 525284000905 Q-loop/lid; other site 525284000906 ABC transporter signature motif; other site 525284000907 Walker B; other site 525284000908 D-loop; other site 525284000909 H-loop/switch region; other site 525284000910 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 525284000911 active site 525284000912 K+ potassium transporter; Region: K_trans; pfam02705 525284000913 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525284000914 Zn2+ binding site [ion binding]; other site 525284000915 Mg2+ binding site [ion binding]; other site 525284000916 Transcriptional regulators [Transcription]; Region: FadR; COG2186 525284000917 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 525284000918 DNA-binding site [nucleotide binding]; DNA binding site 525284000919 FCD domain; Region: FCD; pfam07729 525284000920 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 525284000921 AAA domain; Region: AAA_33; pfam13671 525284000922 ATP-binding site [chemical binding]; other site 525284000923 Gluconate-6-phosphate binding site [chemical binding]; other site 525284000924 fructuronate transporter; Provisional; Region: PRK10034; cl15264 525284000925 GntP family permease; Region: GntP_permease; pfam02447 525284000926 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 525284000927 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 525284000928 Isochorismatase family; Region: Isochorismatase; pfam00857 525284000929 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 525284000930 catalytic triad [active] 525284000931 conserved cis-peptide bond; other site 525284000932 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 525284000933 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 525284000934 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 525284000935 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 525284000936 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 525284000937 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 525284000938 intersubunit interface [polypeptide binding]; other site 525284000939 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 525284000940 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 525284000941 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 525284000942 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 525284000943 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 525284000944 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 525284000945 ABC-ATPase subunit interface; other site 525284000946 dimer interface [polypeptide binding]; other site 525284000947 putative PBP binding regions; other site 525284000948 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 525284000949 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 525284000950 putative acyl-acceptor binding pocket; other site 525284000951 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 525284000952 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 525284000953 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 525284000954 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 525284000955 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 525284000956 ATP-grasp domain; Region: ATP-grasp_4; cl17255 525284000957 CAAX protease self-immunity; Region: Abi; pfam02517 525284000958 homoserine dehydrogenase; Provisional; Region: PRK06349 525284000959 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 525284000960 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 525284000961 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 525284000962 homoserine kinase; Provisional; Region: PRK01212 525284000963 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 525284000964 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 525284000965 putative active site [active] 525284000966 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 525284000967 dimer interface [polypeptide binding]; other site 525284000968 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 525284000969 nudix motif; other site 525284000970 Predicted permeases [General function prediction only]; Region: COG0679 525284000971 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 525284000972 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 525284000973 homodimer interface [polypeptide binding]; other site 525284000974 oligonucleotide binding site [chemical binding]; other site 525284000975 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 525284000976 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 525284000977 GTPase CgtA; Reviewed; Region: obgE; PRK12296 525284000978 GTP1/OBG; Region: GTP1_OBG; pfam01018 525284000979 Obg GTPase; Region: Obg; cd01898 525284000980 G1 box; other site 525284000981 GTP/Mg2+ binding site [chemical binding]; other site 525284000982 Switch I region; other site 525284000983 G2 box; other site 525284000984 G3 box; other site 525284000985 Switch II region; other site 525284000986 G4 box; other site 525284000987 G5 box; other site 525284000988 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 525284000989 gamma-glutamyl kinase; Provisional; Region: PRK05429 525284000990 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 525284000991 nucleotide binding site [chemical binding]; other site 525284000992 homotetrameric interface [polypeptide binding]; other site 525284000993 putative phosphate binding site [ion binding]; other site 525284000994 putative allosteric binding site; other site 525284000995 PUA domain; Region: PUA; pfam01472 525284000996 aspartate aminotransferase; Provisional; Region: PRK05764 525284000997 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 525284000998 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525284000999 homodimer interface [polypeptide binding]; other site 525284001000 catalytic residue [active] 525284001001 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 525284001002 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 525284001003 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 525284001004 putative homodimer interface [polypeptide binding]; other site 525284001005 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 525284001006 heterodimer interface [polypeptide binding]; other site 525284001007 homodimer interface [polypeptide binding]; other site 525284001008 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 525284001009 putative active site [active] 525284001010 putative metal binding site [ion binding]; other site 525284001011 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 525284001012 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 525284001013 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 525284001014 hinge; other site 525284001015 active site 525284001016 potential frameshift: common BLAST hit: gi|283782715|ref|YP_003373469.1| kinase domain protein 525284001017 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 525284001018 Catalytic domain of Protein Kinases; Region: PKc; cd00180 525284001019 active site 525284001020 ATP binding site [chemical binding]; other site 525284001021 substrate binding site [chemical binding]; other site 525284001022 activation loop (A-loop); other site 525284001023 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 525284001024 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 525284001025 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 525284001026 16S/18S rRNA binding site [nucleotide binding]; other site 525284001027 S13e-L30e interaction site [polypeptide binding]; other site 525284001028 25S rRNA binding site [nucleotide binding]; other site 525284001029 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 525284001030 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 525284001031 oligomer interface [polypeptide binding]; other site 525284001032 RNA binding site [nucleotide binding]; other site 525284001033 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 525284001034 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 525284001035 RNase E interface [polypeptide binding]; other site 525284001036 trimer interface [polypeptide binding]; other site 525284001037 active site 525284001038 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 525284001039 putative nucleic acid binding region [nucleotide binding]; other site 525284001040 G-X-X-G motif; other site 525284001041 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 525284001042 RNA binding site [nucleotide binding]; other site 525284001043 domain interface; other site 525284001044 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 525284001045 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 525284001046 active site 525284001047 catalytic tetrad [active] 525284001048 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 525284001049 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 525284001050 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 525284001051 putative substrate binding pocket [chemical binding]; other site 525284001052 AC domain interface; other site 525284001053 catalytic triad [active] 525284001054 AB domain interface; other site 525284001055 interchain disulfide; other site 525284001056 putative mechanosensitive channel protein; Provisional; Region: PRK10929 525284001057 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 525284001058 trimer interface [polypeptide binding]; other site 525284001059 active site 525284001060 G bulge; other site 525284001061 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 525284001062 NusA N-terminal domain; Region: NusA_N; pfam08529 525284001063 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 525284001064 RNA binding site [nucleotide binding]; other site 525284001065 homodimer interface [polypeptide binding]; other site 525284001066 NusA-like KH domain; Region: KH_5; pfam13184 525284001067 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 525284001068 G-X-X-G motif; other site 525284001069 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 525284001070 Rubella capsid protein; Region: Rubella_Capsid; pfam05750 525284001071 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 525284001072 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 525284001073 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 525284001074 G1 box; other site 525284001075 putative GEF interaction site [polypeptide binding]; other site 525284001076 GTP/Mg2+ binding site [chemical binding]; other site 525284001077 Switch I region; other site 525284001078 G2 box; other site 525284001079 G3 box; other site 525284001080 Switch II region; other site 525284001081 G4 box; other site 525284001082 G5 box; other site 525284001083 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 525284001084 Translation-initiation factor 2; Region: IF-2; pfam11987 525284001085 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 525284001086 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 525284001087 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 525284001088 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 525284001089 RNA binding site [nucleotide binding]; other site 525284001090 active site 525284001091 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 525284001092 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 525284001093 active site 525284001094 Riboflavin kinase; Region: Flavokinase; pfam01687 525284001095 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 525284001096 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 525284001097 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 525284001098 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 525284001099 PBP superfamily domain; Region: PBP_like_2; cl17296 525284001100 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 525284001101 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284001102 dimer interface [polypeptide binding]; other site 525284001103 conserved gate region; other site 525284001104 putative PBP binding loops; other site 525284001105 ABC-ATPase subunit interface; other site 525284001106 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 525284001107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284001108 dimer interface [polypeptide binding]; other site 525284001109 conserved gate region; other site 525284001110 putative PBP binding loops; other site 525284001111 ABC-ATPase subunit interface; other site 525284001112 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 525284001113 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 525284001114 Walker A/P-loop; other site 525284001115 ATP binding site [chemical binding]; other site 525284001116 Q-loop/lid; other site 525284001117 ABC transporter signature motif; other site 525284001118 Walker B; other site 525284001119 D-loop; other site 525284001120 H-loop/switch region; other site 525284001121 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 525284001122 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 525284001123 23S rRNA interface [nucleotide binding]; other site 525284001124 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 525284001125 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 525284001126 core dimer interface [polypeptide binding]; other site 525284001127 peripheral dimer interface [polypeptide binding]; other site 525284001128 L10 interface [polypeptide binding]; other site 525284001129 L11 interface [polypeptide binding]; other site 525284001130 putative EF-Tu interaction site [polypeptide binding]; other site 525284001131 putative EF-G interaction site [polypeptide binding]; other site 525284001132 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 525284001133 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 525284001134 L7/L12 interface [polypeptide binding]; other site 525284001135 23S rRNA interface [nucleotide binding]; other site 525284001136 L25 interface [polypeptide binding]; other site 525284001137 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 525284001138 mRNA/rRNA interface [nucleotide binding]; other site 525284001139 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 525284001140 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 525284001141 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 525284001142 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 525284001143 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 525284001144 Walker A/P-loop; other site 525284001145 ATP binding site [chemical binding]; other site 525284001146 ABC transporter signature motif; other site 525284001147 Walker B; other site 525284001148 D-loop; other site 525284001149 H-loop/switch region; other site 525284001150 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 525284001151 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 525284001152 nucleotide binding site [chemical binding]; other site 525284001153 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 525284001154 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 525284001155 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 525284001156 putative ligand binding site [chemical binding]; other site 525284001157 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 525284001158 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 525284001159 Walker A/P-loop; other site 525284001160 ATP binding site [chemical binding]; other site 525284001161 Q-loop/lid; other site 525284001162 ABC transporter signature motif; other site 525284001163 Walker B; other site 525284001164 D-loop; other site 525284001165 H-loop/switch region; other site 525284001166 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 525284001167 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 525284001168 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 525284001169 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 525284001170 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 525284001171 TM-ABC transporter signature motif; other site 525284001172 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 525284001173 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 525284001174 putative N- and C-terminal domain interface [polypeptide binding]; other site 525284001175 putative active site [active] 525284001176 MgATP binding site [chemical binding]; other site 525284001177 catalytic site [active] 525284001178 metal binding site [ion binding]; metal-binding site 525284001179 putative carbohydrate binding site [chemical binding]; other site 525284001180 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 525284001181 intersubunit interface [polypeptide binding]; other site 525284001182 active site 525284001183 Zn2+ binding site [ion binding]; other site 525284001184 L-arabinose isomerase; Provisional; Region: PRK02929 525284001185 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 525284001186 hexamer (dimer of trimers) interface [polypeptide binding]; other site 525284001187 trimer interface [polypeptide binding]; other site 525284001188 substrate binding site [chemical binding]; other site 525284001189 Mn binding site [ion binding]; other site 525284001190 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 525284001191 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 525284001192 active site 525284001193 catalytic tetrad [active] 525284001194 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 525284001195 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 525284001196 Walker A/P-loop; other site 525284001197 ATP binding site [chemical binding]; other site 525284001198 Q-loop/lid; other site 525284001199 ABC transporter signature motif; other site 525284001200 Walker B; other site 525284001201 D-loop; other site 525284001202 H-loop/switch region; other site 525284001203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284001204 dimer interface [polypeptide binding]; other site 525284001205 conserved gate region; other site 525284001206 putative PBP binding loops; other site 525284001207 ABC-ATPase subunit interface; other site 525284001208 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 525284001209 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 525284001210 substrate binding pocket [chemical binding]; other site 525284001211 membrane-bound complex binding site; other site 525284001212 hinge residues; other site 525284001213 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 525284001214 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 525284001215 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 525284001216 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 525284001217 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 525284001218 active site 525284001219 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 525284001220 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 525284001221 NAD binding site [chemical binding]; other site 525284001222 DNA repair protein RadA; Provisional; Region: PRK11823 525284001223 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 525284001224 Walker A motif; other site 525284001225 ATP binding site [chemical binding]; other site 525284001226 Walker B motif; other site 525284001227 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 525284001228 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 525284001229 tetramer (dimer of dimers) interface [polypeptide binding]; other site 525284001230 active site 525284001231 dimer interface [polypeptide binding]; other site 525284001232 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 525284001233 RNA/DNA hybrid binding site [nucleotide binding]; other site 525284001234 active site 525284001235 phosphoglucomutase; Validated; Region: PRK07564 525284001236 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 525284001237 active site 525284001238 substrate binding site [chemical binding]; other site 525284001239 metal binding site [ion binding]; metal-binding site 525284001240 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 525284001241 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 525284001242 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 525284001243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 525284001244 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 525284001245 Uncharacterized conserved protein [Function unknown]; Region: COG4850 525284001246 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 525284001247 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 525284001248 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 525284001249 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 525284001250 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 525284001251 ligand binding site [chemical binding]; other site 525284001252 flexible hinge region; other site 525284001253 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 525284001254 putative switch regulator; other site 525284001255 non-specific DNA interactions [nucleotide binding]; other site 525284001256 DNA binding site [nucleotide binding] 525284001257 sequence specific DNA binding site [nucleotide binding]; other site 525284001258 putative cAMP binding site [chemical binding]; other site 525284001259 Transglycosylase; Region: Transgly; pfam00912 525284001260 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 525284001261 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 525284001262 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 525284001263 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 525284001264 quinone interaction residues [chemical binding]; other site 525284001265 active site 525284001266 catalytic residues [active] 525284001267 FMN binding site [chemical binding]; other site 525284001268 substrate binding site [chemical binding]; other site 525284001269 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 525284001270 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 525284001271 ABC transporter; Region: ABC_tran_2; pfam12848 525284001272 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 525284001273 ribonuclease PH; Reviewed; Region: rph; PRK00173 525284001274 Ribonuclease PH; Region: RNase_PH_bact; cd11362 525284001275 hexamer interface [polypeptide binding]; other site 525284001276 active site 525284001277 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 525284001278 active site 525284001279 dimerization interface [polypeptide binding]; other site 525284001280 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 525284001281 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 525284001282 substrate binding site; other site 525284001283 tetramer interface; other site 525284001284 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 525284001285 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 525284001286 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 525284001287 NADP binding site [chemical binding]; other site 525284001288 active site 525284001289 putative substrate binding site [chemical binding]; other site 525284001290 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 525284001291 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 525284001292 NAD binding site [chemical binding]; other site 525284001293 substrate binding site [chemical binding]; other site 525284001294 homodimer interface [polypeptide binding]; other site 525284001295 active site 525284001296 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 525284001297 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 525284001298 Walker A/P-loop; other site 525284001299 ATP binding site [chemical binding]; other site 525284001300 Q-loop/lid; other site 525284001301 ABC transporter signature motif; other site 525284001302 Walker B; other site 525284001303 D-loop; other site 525284001304 H-loop/switch region; other site 525284001305 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 525284001306 ABC-2 type transporter; Region: ABC2_membrane; cl17235 525284001307 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 525284001308 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525284001309 NAD(P) binding site [chemical binding]; other site 525284001310 active site 525284001311 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525284001312 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 525284001313 active site 525284001314 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 525284001315 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 525284001316 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 525284001317 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 525284001318 active site 525284001319 Rhamnan synthesis protein F; Region: RgpF; pfam05045 525284001320 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 525284001321 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 525284001322 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525284001323 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 525284001324 active site 525284001325 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 525284001326 active site 525284001327 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 525284001328 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 525284001329 UDP-galactopyranose mutase; Region: GLF; pfam03275 525284001330 seryl-tRNA synthetase; Provisional; Region: PRK05431 525284001331 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 525284001332 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 525284001333 dimer interface [polypeptide binding]; other site 525284001334 active site 525284001335 motif 1; other site 525284001336 motif 2; other site 525284001337 motif 3; other site 525284001338 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 525284001339 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 525284001340 catalytic residues [active] 525284001341 Domain of unknown function (DUF348); Region: DUF348; pfam03990 525284001342 G5 domain; Region: G5; pfam07501 525284001343 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 525284001344 N-acetyl-D-glucosamine binding site [chemical binding]; other site 525284001345 catalytic residue [active] 525284001346 Major Facilitator Superfamily; Region: MFS_1; pfam07690 525284001347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525284001348 putative substrate translocation pore; other site 525284001349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525284001350 putative substrate translocation pore; other site 525284001351 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 525284001352 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 525284001353 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 525284001354 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 525284001355 DEAD-like helicases superfamily; Region: DEXDc; smart00487 525284001356 ATP binding site [chemical binding]; other site 525284001357 putative Mg++ binding site [ion binding]; other site 525284001358 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525284001359 nucleotide binding region [chemical binding]; other site 525284001360 ATP-binding site [chemical binding]; other site 525284001361 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 525284001362 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 525284001363 ATP cone domain; Region: ATP-cone; pfam03477 525284001364 Class III ribonucleotide reductase; Region: RNR_III; cd01675 525284001365 effector binding site; other site 525284001366 active site 525284001367 Zn binding site [ion binding]; other site 525284001368 glycine loop; other site 525284001369 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 525284001370 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525284001371 FeS/SAM binding site; other site 525284001372 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525284001373 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 525284001374 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525284001375 Walker A/P-loop; other site 525284001376 ATP binding site [chemical binding]; other site 525284001377 Q-loop/lid; other site 525284001378 ABC transporter signature motif; other site 525284001379 Walker B; other site 525284001380 D-loop; other site 525284001381 H-loop/switch region; other site 525284001382 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525284001383 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 525284001384 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 525284001385 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 525284001386 Walker A/P-loop; other site 525284001387 ATP binding site [chemical binding]; other site 525284001388 Q-loop/lid; other site 525284001389 ABC transporter signature motif; other site 525284001390 Walker B; other site 525284001391 D-loop; other site 525284001392 H-loop/switch region; other site 525284001393 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 525284001394 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 525284001395 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 525284001396 active site 525284001397 substrate binding site [chemical binding]; other site 525284001398 metal binding site [ion binding]; metal-binding site 525284001399 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 525284001400 active site 525284001401 catalytic residues [active] 525284001402 metal binding site [ion binding]; metal-binding site 525284001403 glutamine synthetase, type I; Region: GlnA; TIGR00653 525284001404 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 525284001405 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 525284001406 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 525284001407 Domain of unknown function DUF20; Region: UPF0118; pfam01594 525284001408 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 525284001409 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 525284001410 DXD motif; other site 525284001411 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525284001412 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 525284001413 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 525284001414 Walker A/P-loop; other site 525284001415 ATP binding site [chemical binding]; other site 525284001416 Q-loop/lid; other site 525284001417 ABC transporter signature motif; other site 525284001418 Walker B; other site 525284001419 D-loop; other site 525284001420 H-loop/switch region; other site 525284001421 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 525284001422 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 525284001423 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 525284001424 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 525284001425 Ligand Binding Site [chemical binding]; other site 525284001426 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525284001427 active site 525284001428 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 525284001429 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525284001430 Walker A motif; other site 525284001431 ATP binding site [chemical binding]; other site 525284001432 Walker B motif; other site 525284001433 arginine finger; other site 525284001434 Peptidase family M41; Region: Peptidase_M41; pfam01434 525284001435 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 525284001436 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 525284001437 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 525284001438 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525284001439 Walker A/P-loop; other site 525284001440 ATP binding site [chemical binding]; other site 525284001441 Q-loop/lid; other site 525284001442 ABC transporter signature motif; other site 525284001443 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 525284001444 ABC transporter; Region: ABC_tran_2; pfam12848 525284001445 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 525284001446 FemAB family; Region: FemAB; pfam02388 525284001447 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 525284001448 GA module; Region: GA; pfam01468 525284001449 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 525284001450 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 525284001451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284001452 dimer interface [polypeptide binding]; other site 525284001453 conserved gate region; other site 525284001454 putative PBP binding loops; other site 525284001455 ABC-ATPase subunit interface; other site 525284001456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284001457 dimer interface [polypeptide binding]; other site 525284001458 conserved gate region; other site 525284001459 putative PBP binding loops; other site 525284001460 ABC-ATPase subunit interface; other site 525284001461 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 525284001462 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 525284001463 KIAA1161 is an uncharacterized Homo sapiens protein with a glycosyl hydrolase family 31 (GH31) domain that is homologous to the Escherichia coli YihQ glucosidase. Orthologs of KIA1161 are found in eukaryotes and prokaryotes. In bacteria, YihQ (along with...; Region: GH31_glucosidase_KIAA1161; cd06592 525284001464 putative active site [active] 525284001465 putative catalytic site [active] 525284001466 Transcriptional regulators [Transcription]; Region: PurR; COG1609 525284001467 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 525284001468 DNA binding site [nucleotide binding] 525284001469 domain linker motif; other site 525284001470 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 525284001471 dimerization interface [polypeptide binding]; other site 525284001472 ligand binding site [chemical binding]; other site 525284001473 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 525284001474 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 525284001475 Soluble P-type ATPase [General function prediction only]; Region: COG4087 525284001476 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 525284001477 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 525284001478 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 525284001479 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 525284001480 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 525284001481 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 525284001482 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 525284001483 LexA repressor; Validated; Region: PRK00215 525284001484 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 525284001485 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 525284001486 Catalytic site [active] 525284001487 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 525284001488 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 525284001489 ATP cone domain; Region: ATP-cone; pfam03477 525284001490 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 525284001491 Part of AAA domain; Region: AAA_19; pfam13245 525284001492 Family description; Region: UvrD_C_2; pfam13538 525284001493 MraZ protein; Region: MraZ; pfam02381 525284001494 cell division protein MraZ; Reviewed; Region: PRK00326 525284001495 MraZ protein; Region: MraZ; pfam02381 525284001496 MraW methylase family; Region: Methyltransf_5; cl17771 525284001497 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 525284001498 potential frameshift: common BLAST hit: gi|283783554|ref|YP_003374308.1| penicillin-binding protein, transpeptidase domain protein 525284001499 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 525284001500 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 525284001501 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 525284001502 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 525284001503 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 525284001504 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 525284001505 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 525284001506 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 525284001507 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 525284001508 Mg++ binding site [ion binding]; other site 525284001509 putative catalytic motif [active] 525284001510 putative substrate binding site [chemical binding]; other site 525284001511 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 525284001512 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 525284001513 cell division protein FtsW; Region: ftsW; TIGR02614 525284001514 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 525284001515 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 525284001516 active site 525284001517 homodimer interface [polypeptide binding]; other site 525284001518 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 525284001519 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 525284001520 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 525284001521 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 525284001522 cell division protein FtsQ; Provisional; Region: PRK05529 525284001523 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 525284001524 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 525284001525 S17 interaction site [polypeptide binding]; other site 525284001526 S8 interaction site; other site 525284001527 16S rRNA interaction site [nucleotide binding]; other site 525284001528 streptomycin interaction site [chemical binding]; other site 525284001529 23S rRNA interaction site [nucleotide binding]; other site 525284001530 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 525284001531 30S ribosomal protein S7; Validated; Region: PRK05302 525284001532 elongation factor G; Reviewed; Region: PRK00007 525284001533 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 525284001534 G1 box; other site 525284001535 putative GEF interaction site [polypeptide binding]; other site 525284001536 GTP/Mg2+ binding site [chemical binding]; other site 525284001537 Switch I region; other site 525284001538 G2 box; other site 525284001539 G3 box; other site 525284001540 Switch II region; other site 525284001541 G4 box; other site 525284001542 G5 box; other site 525284001543 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 525284001544 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 525284001545 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 525284001546 elongation factor Tu; Reviewed; Region: PRK00049 525284001547 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 525284001548 G1 box; other site 525284001549 GEF interaction site [polypeptide binding]; other site 525284001550 GTP/Mg2+ binding site [chemical binding]; other site 525284001551 Switch I region; other site 525284001552 G2 box; other site 525284001553 G3 box; other site 525284001554 Switch II region; other site 525284001555 G4 box; other site 525284001556 G5 box; other site 525284001557 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 525284001558 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 525284001559 Antibiotic Binding Site [chemical binding]; other site 525284001560 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 525284001561 putative active site [active] 525284001562 catalytic triad [active] 525284001563 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 525284001564 PA/protease or protease-like domain interface [polypeptide binding]; other site 525284001565 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 525284001566 catalytic residues [active] 525284001567 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 525284001568 potential frameshift: common BLAST hit: gi|283782921|ref|YP_003373675.1| exodeoxyribonuclease VII, large subunit 525284001569 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 525284001570 generic binding surface II; other site 525284001571 generic binding surface I; other site 525284001572 Exonuclease VII, large subunit; Region: Exonuc_VII_L; pfam02601 525284001573 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 525284001574 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 525284001575 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 525284001576 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 525284001577 HIGH motif; other site 525284001578 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 525284001579 active site 525284001580 KMSKS motif; other site 525284001581 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 525284001582 tRNA binding surface [nucleotide binding]; other site 525284001583 anticodon binding site; other site 525284001584 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 525284001585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284001586 dimer interface [polypeptide binding]; other site 525284001587 conserved gate region; other site 525284001588 putative PBP binding loops; other site 525284001589 ABC-ATPase subunit interface; other site 525284001590 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 525284001591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284001592 dimer interface [polypeptide binding]; other site 525284001593 conserved gate region; other site 525284001594 putative PBP binding loops; other site 525284001595 ABC-ATPase subunit interface; other site 525284001596 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 525284001597 peptide binding site [polypeptide binding]; other site 525284001598 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 525284001599 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 525284001600 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 525284001601 Walker A/P-loop; other site 525284001602 ATP binding site [chemical binding]; other site 525284001603 Q-loop/lid; other site 525284001604 ABC transporter signature motif; other site 525284001605 Walker B; other site 525284001606 D-loop; other site 525284001607 H-loop/switch region; other site 525284001608 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 525284001609 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 525284001610 Walker A/P-loop; other site 525284001611 ATP binding site [chemical binding]; other site 525284001612 Q-loop/lid; other site 525284001613 ABC transporter signature motif; other site 525284001614 Walker B; other site 525284001615 D-loop; other site 525284001616 H-loop/switch region; other site 525284001617 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 525284001618 glutamate racemase; Provisional; Region: PRK00865 525284001619 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 525284001620 putative active site [active] 525284001621 redox center [active] 525284001622 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 525284001623 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 525284001624 active site 525284001625 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 525284001626 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 525284001627 Phosphotransferase enzyme family; Region: APH; pfam01636 525284001628 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 525284001629 substrate binding site [chemical binding]; other site 525284001630 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 525284001631 Part of AAA domain; Region: AAA_19; pfam13245 525284001632 Family description; Region: UvrD_C_2; pfam13538 525284001633 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 525284001634 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 525284001635 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 525284001636 Cna protein B-type domain; Region: Cna_B; pfam05738 525284001637 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 525284001638 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 525284001639 active site 525284001640 catalytic site [active] 525284001641 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 525284001642 DivIVA domain; Region: DivI1A_domain; TIGR03544 525284001643 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 525284001644 Recombination protein O N terminal; Region: RecO_N; pfam11967 525284001645 Recombination protein O C terminal; Region: RecO_C; pfam02565 525284001646 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 525284001647 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 525284001648 NMT1/THI5 like; Region: NMT1; pfam09084 525284001649 Phosphotransferase enzyme family; Region: APH; pfam01636 525284001650 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 525284001651 substrate binding site [chemical binding]; other site 525284001652 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829 525284001653 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 525284001654 catalytic residue [active] 525284001655 putative FPP diphosphate binding site; other site 525284001656 putative FPP binding hydrophobic cleft; other site 525284001657 dimer interface [polypeptide binding]; other site 525284001658 putative IPP diphosphate binding site; other site 525284001659 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 525284001660 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 525284001661 metal binding site [ion binding]; metal-binding site 525284001662 putative dimer interface [polypeptide binding]; other site 525284001663 Domain of unknown function DUF77; Region: DUF77; pfam01910 525284001664 glycyl-tRNA synthetase; Provisional; Region: PRK04173 525284001665 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 525284001666 motif 1; other site 525284001667 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 525284001668 active site 525284001669 motif 2; other site 525284001670 motif 3; other site 525284001671 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 525284001672 anticodon binding site; other site 525284001673 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 525284001674 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 525284001675 FMN binding site [chemical binding]; other site 525284001676 active site 525284001677 catalytic residues [active] 525284001678 substrate binding site [chemical binding]; other site 525284001679 cell division protein FtsZ; Validated; Region: PRK09330 525284001680 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 525284001681 nucleotide binding site [chemical binding]; other site 525284001682 SulA interaction site; other site 525284001683 Protein of unknown function (DUF552); Region: DUF552; pfam04472 525284001684 YGGT family; Region: YGGT; cl00508 525284001685 DivIVA protein; Region: DivIVA; pfam05103 525284001686 DivIVA domain; Region: DivI1A_domain; TIGR03544 525284001687 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 525284001688 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 525284001689 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 525284001690 active site 525284001691 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 525284001692 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 525284001693 active site 525284001694 PHP Thumb interface [polypeptide binding]; other site 525284001695 metal binding site [ion binding]; metal-binding site 525284001696 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 525284001697 generic binding surface II; other site 525284001698 generic binding surface I; other site 525284001699 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 525284001700 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 525284001701 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 525284001702 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 525284001703 active site 525284001704 Major Facilitator Superfamily; Region: MFS_1; pfam07690 525284001705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525284001706 putative substrate translocation pore; other site 525284001707 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 525284001708 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525284001709 ATP binding site [chemical binding]; other site 525284001710 putative Mg++ binding site [ion binding]; other site 525284001711 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525284001712 nucleotide binding region [chemical binding]; other site 525284001713 ATP-binding site [chemical binding]; other site 525284001714 Helicase associated domain (HA2); Region: HA2; pfam04408 525284001715 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 525284001716 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 525284001717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525284001718 S-adenosylmethionine binding site [chemical binding]; other site 525284001719 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 525284001720 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 525284001721 HflX GTPase family; Region: HflX; cd01878 525284001722 G1 box; other site 525284001723 GTP/Mg2+ binding site [chemical binding]; other site 525284001724 Switch I region; other site 525284001725 G2 box; other site 525284001726 G3 box; other site 525284001727 Switch II region; other site 525284001728 G4 box; other site 525284001729 G5 box; other site 525284001730 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 525284001731 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 525284001732 NAD binding site [chemical binding]; other site 525284001733 dimer interface [polypeptide binding]; other site 525284001734 substrate binding site [chemical binding]; other site 525284001735 tetramer (dimer of dimers) interface [polypeptide binding]; other site 525284001736 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 525284001737 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 525284001738 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 525284001739 catalytic residue [active] 525284001740 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 525284001741 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 525284001742 active site 525284001743 trimerization site [polypeptide binding]; other site 525284001744 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 525284001745 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 525284001746 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 525284001747 Protein of unknown function (DUF4125); Region: DUF4125; pfam13526 525284001748 potential frameshift: common BLAST hit: gi|283782887|ref|YP_003373641.1| tetratricopeptide repeat protein 525284001749 Tetratricopeptide repeat; Region: TPR_12; pfam13424 525284001750 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525284001751 binding surface 525284001752 TPR motif; other site 525284001753 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 525284001754 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 525284001755 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 525284001756 dimer interface [polypeptide binding]; other site 525284001757 putative anticodon binding site; other site 525284001758 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 525284001759 motif 1; other site 525284001760 dimer interface [polypeptide binding]; other site 525284001761 active site 525284001762 motif 2; other site 525284001763 motif 3; other site 525284001764 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 525284001765 catalytic core [active] 525284001766 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 525284001767 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 525284001768 PhoU domain; Region: PhoU; pfam01895 525284001769 PhoU domain; Region: PhoU; pfam01895 525284001770 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525284001771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525284001772 ATP binding site [chemical binding]; other site 525284001773 Mg2+ binding site [ion binding]; other site 525284001774 G-X-G motif; other site 525284001775 Surface antigen [General function prediction only]; Region: COG3942 525284001776 CHAP domain; Region: CHAP; pfam05257 525284001777 NlpC/P60 family; Region: NLPC_P60; pfam00877 525284001778 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 525284001779 Ligand Binding Site [chemical binding]; other site 525284001780 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 525284001781 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525284001782 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 525284001783 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 525284001784 thymidylate synthase; Reviewed; Region: thyA; PRK01827 525284001785 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 525284001786 dimerization interface [polypeptide binding]; other site 525284001787 active site 525284001788 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 525284001789 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 525284001790 folate binding site [chemical binding]; other site 525284001791 NADP+ binding site [chemical binding]; other site 525284001792 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 525284001793 Low molecular weight phosphatase family; Region: LMWPc; cd00115 525284001794 active site 525284001795 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 525284001796 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 525284001797 hypothetical protein; Provisional; Region: PRK07907 525284001798 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 525284001799 active site 525284001800 metal binding site [ion binding]; metal-binding site 525284001801 dimer interface [polypeptide binding]; other site 525284001802 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 525284001803 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 525284001804 Walker A/P-loop; other site 525284001805 ATP binding site [chemical binding]; other site 525284001806 Q-loop/lid; other site 525284001807 ABC transporter signature motif; other site 525284001808 Walker B; other site 525284001809 D-loop; other site 525284001810 H-loop/switch region; other site 525284001811 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 525284001812 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 525284001813 Walker A/P-loop; other site 525284001814 ATP binding site [chemical binding]; other site 525284001815 Q-loop/lid; other site 525284001816 ABC transporter signature motif; other site 525284001817 Walker B; other site 525284001818 D-loop; other site 525284001819 H-loop/switch region; other site 525284001820 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 525284001821 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 525284001822 substrate binding site [chemical binding]; other site 525284001823 multimerization interface [polypeptide binding]; other site 525284001824 ATP binding site [chemical binding]; other site 525284001825 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 525284001826 thiamine phosphate binding site [chemical binding]; other site 525284001827 active site 525284001828 pyrophosphate binding site [ion binding]; other site 525284001829 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 525284001830 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 525284001831 Walker A/P-loop; other site 525284001832 ATP binding site [chemical binding]; other site 525284001833 Q-loop/lid; other site 525284001834 ABC transporter signature motif; other site 525284001835 Walker B; other site 525284001836 D-loop; other site 525284001837 H-loop/switch region; other site 525284001838 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 525284001839 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 525284001840 Walker A/P-loop; other site 525284001841 ATP binding site [chemical binding]; other site 525284001842 Q-loop/lid; other site 525284001843 ABC transporter signature motif; other site 525284001844 Walker B; other site 525284001845 D-loop; other site 525284001846 H-loop/switch region; other site 525284001847 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 525284001848 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 525284001849 UbiA prenyltransferase family; Region: UbiA; pfam01040 525284001850 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 525284001851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525284001852 active site 525284001853 phosphorylation site [posttranslational modification] 525284001854 intermolecular recognition site; other site 525284001855 dimerization interface [polypeptide binding]; other site 525284001856 ANTAR domain; Region: ANTAR; pfam03861 525284001857 5'-3' exonuclease; Region: 53EXOc; smart00475 525284001858 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 525284001859 active site 525284001860 metal binding site 1 [ion binding]; metal-binding site 525284001861 putative 5' ssDNA interaction site; other site 525284001862 metal binding site 3; metal-binding site 525284001863 metal binding site 2 [ion binding]; metal-binding site 525284001864 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 525284001865 putative DNA binding site [nucleotide binding]; other site 525284001866 putative metal binding site [ion binding]; other site 525284001867 DNA polymerase I; Provisional; Region: PRK05755 525284001868 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 525284001869 active site 525284001870 substrate binding site [chemical binding]; other site 525284001871 catalytic site [active] 525284001872 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 525284001873 active site 525284001874 DNA binding site [nucleotide binding] 525284001875 catalytic site [active] 525284001876 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 525284001877 Uncharacterized conserved protein [Function unknown]; Region: COG0327 525284001878 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 525284001879 L-aspartate oxidase; Provisional; Region: PRK06175 525284001880 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 525284001881 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 525284001882 DNA protecting protein DprA; Region: dprA; TIGR00732 525284001883 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 525284001884 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 525284001885 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 525284001886 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 525284001887 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 525284001888 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 525284001889 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 525284001890 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 525284001891 active site 525284001892 catalytic site [active] 525284001893 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 525284001894 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 525284001895 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 525284001896 Walker A/P-loop; other site 525284001897 ATP binding site [chemical binding]; other site 525284001898 Q-loop/lid; other site 525284001899 ABC transporter signature motif; other site 525284001900 Walker B; other site 525284001901 D-loop; other site 525284001902 H-loop/switch region; other site 525284001903 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 525284001904 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 525284001905 Walker A/P-loop; other site 525284001906 ATP binding site [chemical binding]; other site 525284001907 Q-loop/lid; other site 525284001908 ABC transporter signature motif; other site 525284001909 Walker B; other site 525284001910 D-loop; other site 525284001911 H-loop/switch region; other site 525284001912 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 525284001913 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 525284001914 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 525284001915 hinge; other site 525284001916 active site 525284001917 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 525284001918 propionate/acetate kinase; Provisional; Region: PRK12379 525284001919 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 525284001920 putative phosphoketolase; Provisional; Region: PRK05261 525284001921 XFP N-terminal domain; Region: XFP_N; pfam09364 525284001922 XFP C-terminal domain; Region: XFP_C; pfam09363 525284001923 GMP synthase; Reviewed; Region: guaA; PRK00074 525284001924 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 525284001925 AMP/PPi binding site [chemical binding]; other site 525284001926 candidate oxyanion hole; other site 525284001927 catalytic triad [active] 525284001928 potential glutamine specificity residues [chemical binding]; other site 525284001929 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 525284001930 ATP Binding subdomain [chemical binding]; other site 525284001931 Ligand Binding sites [chemical binding]; other site 525284001932 Dimerization subdomain; other site 525284001933 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 525284001934 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 525284001935 active site 525284001936 Ca binding site [ion binding]; other site 525284001937 catalytic site [active] 525284001938 Aamy_C domain; Region: Aamy_C; smart00632 525284001939 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 525284001940 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 525284001941 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 525284001942 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 525284001943 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 525284001944 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 525284001945 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 525284001946 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 525284001947 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 525284001948 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 525284001949 dimer interface [polypeptide binding]; other site 525284001950 motif 1; other site 525284001951 active site 525284001952 motif 2; other site 525284001953 motif 3; other site 525284001954 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 525284001955 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 525284001956 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 525284001957 putative tRNA-binding site [nucleotide binding]; other site 525284001958 B3/4 domain; Region: B3_4; pfam03483 525284001959 tRNA synthetase B5 domain; Region: B5; pfam03484 525284001960 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 525284001961 dimer interface [polypeptide binding]; other site 525284001962 motif 1; other site 525284001963 motif 3; other site 525284001964 motif 2; other site 525284001965 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 525284001966 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 525284001967 Arginine repressor [Transcription]; Region: ArgR; COG1438 525284001968 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 525284001969 argininosuccinate synthase; Provisional; Region: PRK13820 525284001970 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 525284001971 ANP binding site [chemical binding]; other site 525284001972 Substrate Binding Site II [chemical binding]; other site 525284001973 Substrate Binding Site I [chemical binding]; other site 525284001974 argininosuccinate lyase; Provisional; Region: PRK00855 525284001975 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 525284001976 active sites [active] 525284001977 tetramer interface [polypeptide binding]; other site 525284001978 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 525284001979 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 525284001980 active site 525284001981 HIGH motif; other site 525284001982 dimer interface [polypeptide binding]; other site 525284001983 KMSKS motif; other site 525284001984 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 525284001985 RNA binding surface [nucleotide binding]; other site 525284001986 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 525284001987 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525284001988 active site 525284001989 motif I; other site 525284001990 motif II; other site 525284001991 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 525284001992 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 525284001993 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 525284001994 RNA binding surface [nucleotide binding]; other site 525284001995 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 525284001996 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 525284001997 ATP-NAD kinase; Region: NAD_kinase; pfam01513 525284001998 potential frameshift: common BLAST hit: gi|283783155|ref|YP_003373909.1| DNA repair protein RecN 525284001999 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525284002000 Walker A/P-loop; other site 525284002001 ATP binding site [chemical binding]; other site 525284002002 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 525284002003 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525284002004 Q-loop/lid; other site 525284002005 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 525284002006 ABC transporter signature motif; other site 525284002007 Walker B; other site 525284002008 D-loop; other site 525284002009 H-loop/switch region; other site 525284002010 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 525284002011 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525284002012 motif II; other site 525284002013 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 525284002014 30S subunit binding site; other site 525284002015 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 525284002016 DEAD/DEAH box helicase; Region: DEAD; pfam00270 525284002017 ATP binding site [chemical binding]; other site 525284002018 putative Mg++ binding site [ion binding]; other site 525284002019 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 525284002020 SEC-C motif; Region: SEC-C; pfam02810 525284002021 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 525284002022 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 525284002023 putative acyl-acceptor binding pocket; other site 525284002024 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 525284002025 Catalytic domain of Protein Kinases; Region: PKc; cd00180 525284002026 active site 525284002027 ATP binding site [chemical binding]; other site 525284002028 substrate binding site [chemical binding]; other site 525284002029 activation loop (A-loop); other site 525284002030 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 525284002031 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 525284002032 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 525284002033 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 525284002034 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 525284002035 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 525284002036 substrate binding pocket [chemical binding]; other site 525284002037 chain length determination region; other site 525284002038 substrate-Mg2+ binding site; other site 525284002039 catalytic residues [active] 525284002040 aspartate-rich region 1; other site 525284002041 active site lid residues [active] 525284002042 aspartate-rich region 2; other site 525284002043 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 525284002044 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 525284002045 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 525284002046 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 525284002047 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 525284002048 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 525284002049 DNA binding residues [nucleotide binding] 525284002050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525284002051 ATP binding site [chemical binding]; other site 525284002052 Mg2+ binding site [ion binding]; other site 525284002053 G-X-G motif; other site 525284002054 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 525284002055 anchoring element; other site 525284002056 dimer interface [polypeptide binding]; other site 525284002057 ATP binding site [chemical binding]; other site 525284002058 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 525284002059 active site 525284002060 putative metal-binding site [ion binding]; other site 525284002061 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 525284002062 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 525284002063 Protein of unknown function (DUF3791); Region: DUF3791; pfam12668 525284002064 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 525284002065 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 525284002066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525284002067 Major Facilitator Superfamily; Region: MFS_1; pfam07690 525284002068 putative substrate translocation pore; other site 525284002069 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 525284002070 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 525284002071 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 525284002072 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 525284002073 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 525284002074 CAP-like domain; other site 525284002075 active site 525284002076 primary dimer interface [polypeptide binding]; other site 525284002077 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 525284002078 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 525284002079 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 525284002080 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 525284002081 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 525284002082 trimer interface [polypeptide binding]; other site 525284002083 active site 525284002084 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 525284002085 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525284002086 Zn2+ binding site [ion binding]; other site 525284002087 Mg2+ binding site [ion binding]; other site 525284002088 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 525284002089 synthetase active site [active] 525284002090 NTP binding site [chemical binding]; other site 525284002091 metal binding site [ion binding]; metal-binding site 525284002092 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 525284002093 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 525284002094 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 525284002095 active site 525284002096 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 525284002097 thiamine phosphate binding site [chemical binding]; other site 525284002098 active site 525284002099 pyrophosphate binding site [ion binding]; other site 525284002100 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 525284002101 ThiC-associated domain; Region: ThiC-associated; pfam13667 525284002102 ThiC family; Region: ThiC; pfam01964 525284002103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284002104 dimer interface [polypeptide binding]; other site 525284002105 conserved gate region; other site 525284002106 putative PBP binding loops; other site 525284002107 ABC-ATPase subunit interface; other site 525284002108 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 525284002109 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 525284002110 Walker A/P-loop; other site 525284002111 ATP binding site [chemical binding]; other site 525284002112 Q-loop/lid; other site 525284002113 ABC transporter signature motif; other site 525284002114 Walker B; other site 525284002115 D-loop; other site 525284002116 H-loop/switch region; other site 525284002117 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 525284002118 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 525284002119 NAD synthetase; Provisional; Region: PRK13981 525284002120 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 525284002121 multimer interface [polypeptide binding]; other site 525284002122 active site 525284002123 catalytic triad [active] 525284002124 protein interface 1 [polypeptide binding]; other site 525284002125 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 525284002126 homodimer interface [polypeptide binding]; other site 525284002127 NAD binding pocket [chemical binding]; other site 525284002128 ATP binding pocket [chemical binding]; other site 525284002129 Mg binding site [ion binding]; other site 525284002130 active-site loop [active] 525284002131 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 525284002132 Pyruvate formate lyase 1; Region: PFL1; cd01678 525284002133 coenzyme A binding site [chemical binding]; other site 525284002134 active site 525284002135 catalytic residues [active] 525284002136 glycine loop; other site 525284002137 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 525284002138 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525284002139 FeS/SAM binding site; other site 525284002140 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 525284002141 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 525284002142 active site 525284002143 catalytic site [active] 525284002144 substrate binding site [chemical binding]; other site 525284002145 HRDC domain; Region: HRDC; pfam00570 525284002146 trigger factor; Provisional; Region: tig; PRK01490 525284002147 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 525284002148 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 525284002149 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 525284002150 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 525284002151 Cl- selectivity filter; other site 525284002152 Cl- binding residues [ion binding]; other site 525284002153 pore gating glutamate residue; other site 525284002154 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 525284002155 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 525284002156 dimer interface [polypeptide binding]; other site 525284002157 Clp protease; Region: CLP_protease; pfam00574 525284002158 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 525284002159 oligomer interface [polypeptide binding]; other site 525284002160 active site residues [active] 525284002161 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 525284002162 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 525284002163 oligomer interface [polypeptide binding]; other site 525284002164 active site residues [active] 525284002165 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 525284002166 IHF dimer interface [polypeptide binding]; other site 525284002167 IHF - DNA interface [nucleotide binding]; other site 525284002168 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 525284002169 adenylosuccinate lyase; Provisional; Region: PRK09285 525284002170 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 525284002171 tetramer interface [polypeptide binding]; other site 525284002172 active site 525284002173 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 525284002174 PGAP1-like protein; Region: PGAP1; pfam07819 525284002175 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 525284002176 metal ion-dependent adhesion site (MIDAS); other site 525284002177 von Willebrand factor type A domain; Region: VWA_2; pfam13519 525284002178 metal ion-dependent adhesion site (MIDAS); other site 525284002179 enhanced disease resistance protein (EDR2); Provisional; Region: PLN00188 525284002180 Protein of unknown function DUF58; Region: DUF58; pfam01882 525284002181 MoxR-like ATPases [General function prediction only]; Region: COG0714 525284002182 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 525284002183 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 525284002184 ligand binding site [chemical binding]; other site 525284002185 active site 525284002186 UGI interface [polypeptide binding]; other site 525284002187 catalytic site [active] 525284002188 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 525284002189 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 525284002190 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 525284002191 ring oligomerisation interface [polypeptide binding]; other site 525284002192 ATP/Mg binding site [chemical binding]; other site 525284002193 stacking interactions; other site 525284002194 hinge regions; other site 525284002195 Proteins of 100 residues with WXG; Region: WXG100; cl02005 525284002196 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 525284002197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525284002198 active site 525284002199 phosphorylation site [posttranslational modification] 525284002200 intermolecular recognition site; other site 525284002201 dimerization interface [polypeptide binding]; other site 525284002202 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 525284002203 DNA binding site [nucleotide binding] 525284002204 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525284002205 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 525284002206 dimerization interface [polypeptide binding]; other site 525284002207 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525284002208 dimer interface [polypeptide binding]; other site 525284002209 phosphorylation site [posttranslational modification] 525284002210 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525284002211 ATP binding site [chemical binding]; other site 525284002212 Mg2+ binding site [ion binding]; other site 525284002213 G-X-G motif; other site 525284002214 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 525284002215 DNA-binding site [nucleotide binding]; DNA binding site 525284002216 RNA-binding motif; other site 525284002217 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 525284002218 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 525284002219 Clp amino terminal domain; Region: Clp_N; pfam02861 525284002220 Clp amino terminal domain; Region: Clp_N; pfam02861 525284002221 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525284002222 Walker A motif; other site 525284002223 ATP binding site [chemical binding]; other site 525284002224 Walker B motif; other site 525284002225 arginine finger; other site 525284002226 UvrB/uvrC motif; Region: UVR; pfam02151 525284002227 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525284002228 Walker A motif; other site 525284002229 ATP binding site [chemical binding]; other site 525284002230 Walker B motif; other site 525284002231 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 525284002232 GIY-YIG domain of uncharacterized bacterial protein structurally related to COG3410; Region: GIY-YIG_COG3410; cd10439 525284002233 GIY-YIG motif/motif A; other site 525284002234 putative active site [active] 525284002235 putative metal binding site [ion binding]; other site 525284002236 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 525284002237 Uncharacterized conserved protein [Function unknown]; Region: COG3410 525284002238 potential frameshift: common BLAST hit: gi|283783229|ref|YP_003373983.1| CRISPR-associated helicase Cas3 525284002239 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 525284002240 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 525284002241 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 525284002242 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 525284002243 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 525284002244 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 525284002245 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 525284002246 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 525284002247 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 525284002248 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 525284002249 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 525284002250 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 525284002251 active site 525284002252 catalytic site [active] 525284002253 substrate binding site [chemical binding]; other site 525284002254 Transcriptional regulator [Transcription]; Region: LysR; COG0583 525284002255 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 525284002256 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 525284002257 dimerization interface [polypeptide binding]; other site 525284002258 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 525284002259 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525284002260 motif II; other site 525284002261 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 525284002262 putative substrate binding site [chemical binding]; other site 525284002263 putative ATP binding site [chemical binding]; other site 525284002264 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 525284002265 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 525284002266 intersubunit interface [polypeptide binding]; other site 525284002267 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 525284002268 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 525284002269 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 525284002270 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 525284002271 ABC-ATPase subunit interface; other site 525284002272 dimer interface [polypeptide binding]; other site 525284002273 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 525284002274 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 525284002275 ABC-ATPase subunit interface; other site 525284002276 dimer interface [polypeptide binding]; other site 525284002277 putative PBP binding regions; other site 525284002278 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 525284002279 thiS-thiF/thiG interaction site; other site 525284002280 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 525284002281 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 525284002282 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 525284002283 active site 525284002284 dimer interface [polypeptide binding]; other site 525284002285 motif 1; other site 525284002286 motif 2; other site 525284002287 motif 3; other site 525284002288 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 525284002289 anticodon binding site; other site 525284002290 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 525284002291 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 525284002292 inhibitor site; inhibition site 525284002293 active site 525284002294 dimer interface [polypeptide binding]; other site 525284002295 catalytic residue [active] 525284002296 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 525284002297 Amidohydrolase; Region: Amidohydro_2; pfam04909 525284002298 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 525284002299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525284002300 putative substrate translocation pore; other site 525284002301 short chain dehydrogenase; Provisional; Region: PRK08628 525284002302 classical (c) SDRs; Region: SDR_c; cd05233 525284002303 NAD(P) binding site [chemical binding]; other site 525284002304 active site 525284002305 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 525284002306 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 525284002307 metal binding site [ion binding]; metal-binding site 525284002308 substrate binding pocket [chemical binding]; other site 525284002309 Transcriptional regulators [Transcription]; Region: PurR; COG1609 525284002310 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 525284002311 DNA binding site [nucleotide binding] 525284002312 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 525284002313 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 525284002314 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 525284002315 dimer interface [polypeptide binding]; other site 525284002316 active site 525284002317 metal binding site [ion binding]; metal-binding site 525284002318 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525284002319 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 525284002320 Walker A/P-loop; other site 525284002321 ATP binding site [chemical binding]; other site 525284002322 Q-loop/lid; other site 525284002323 ABC transporter signature motif; other site 525284002324 Walker B; other site 525284002325 D-loop; other site 525284002326 H-loop/switch region; other site 525284002327 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 525284002328 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 525284002329 FtsX-like permease family; Region: FtsX; pfam02687 525284002330 FtsX-like permease family; Region: FtsX; pfam02687 525284002331 Spc7 kinetochore protein; Region: Spc7; smart00787 525284002332 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 525284002333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525284002334 active site 525284002335 phosphorylation site [posttranslational modification] 525284002336 intermolecular recognition site; other site 525284002337 dimerization interface [polypeptide binding]; other site 525284002338 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 525284002339 DNA binding residues [nucleotide binding] 525284002340 dimerization interface [polypeptide binding]; other site 525284002341 Histidine kinase; Region: HisKA_3; pfam07730 525284002342 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 525284002343 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 525284002344 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 525284002345 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 525284002346 GTP-binding protein YchF; Reviewed; Region: PRK09601 525284002347 YchF GTPase; Region: YchF; cd01900 525284002348 G1 box; other site 525284002349 GTP/Mg2+ binding site [chemical binding]; other site 525284002350 Switch I region; other site 525284002351 G2 box; other site 525284002352 Switch II region; other site 525284002353 G3 box; other site 525284002354 G4 box; other site 525284002355 G5 box; other site 525284002356 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 525284002357 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 525284002358 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 525284002359 Predicted membrane protein [Function unknown]; Region: COG2855 525284002360 Protein of unknown function, DUF488; Region: DUF488; cl01246 525284002361 uracil transporter; Provisional; Region: PRK10720 525284002362 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 525284002363 Uncharacterized conserved protein [Function unknown]; Region: COG1615 525284002364 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 525284002365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284002366 dimer interface [polypeptide binding]; other site 525284002367 conserved gate region; other site 525284002368 putative PBP binding loops; other site 525284002369 ABC-ATPase subunit interface; other site 525284002370 NMT1/THI5 like; Region: NMT1; pfam09084 525284002371 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 525284002372 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 525284002373 putative active site [active] 525284002374 catalytic residue [active] 525284002375 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 525284002376 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 525284002377 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525284002378 ATP binding site [chemical binding]; other site 525284002379 putative Mg++ binding site [ion binding]; other site 525284002380 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525284002381 nucleotide binding region [chemical binding]; other site 525284002382 ATP-binding site [chemical binding]; other site 525284002383 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 525284002384 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 525284002385 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525284002386 Walker A/P-loop; other site 525284002387 ATP binding site [chemical binding]; other site 525284002388 Q-loop/lid; other site 525284002389 ABC transporter signature motif; other site 525284002390 Walker B; other site 525284002391 D-loop; other site 525284002392 H-loop/switch region; other site 525284002393 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 525284002394 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 525284002395 membrane-bound complex binding site; other site 525284002396 hinge residues; other site 525284002397 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 525284002398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284002399 dimer interface [polypeptide binding]; other site 525284002400 conserved gate region; other site 525284002401 putative PBP binding loops; other site 525284002402 ABC-ATPase subunit interface; other site 525284002403 enolase; Provisional; Region: eno; PRK00077 525284002404 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 525284002405 dimer interface [polypeptide binding]; other site 525284002406 metal binding site [ion binding]; metal-binding site 525284002407 substrate binding pocket [chemical binding]; other site 525284002408 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 525284002409 tetramer (dimer of dimers) interface [polypeptide binding]; other site 525284002410 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 525284002411 NAD binding site [chemical binding]; other site 525284002412 dimer interface [polypeptide binding]; other site 525284002413 substrate binding site [chemical binding]; other site 525284002414 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 525284002415 Septum formation initiator; Region: DivIC; pfam04977 525284002416 Protein of unknown function (DUF501); Region: DUF501; pfam04417 525284002417 exopolyphosphatase; Region: exo_poly_only; TIGR03706 525284002418 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 525284002419 nucleotide binding site [chemical binding]; other site 525284002420 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 525284002421 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 525284002422 homodimer interface [polypeptide binding]; other site 525284002423 substrate-cofactor binding pocket; other site 525284002424 catalytic residue [active] 525284002425 Predicted membrane protein [Function unknown]; Region: COG2860 525284002426 UPF0126 domain; Region: UPF0126; pfam03458 525284002427 UPF0126 domain; Region: UPF0126; pfam03458 525284002428 lysine transporter; Provisional; Region: PRK10836 525284002429 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 525284002430 Peptidase family M23; Region: Peptidase_M23; pfam01551 525284002431 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 525284002432 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 525284002433 acyl-activating enzyme (AAE) consensus motif; other site 525284002434 putative AMP binding site [chemical binding]; other site 525284002435 putative active site [active] 525284002436 putative CoA binding site [chemical binding]; other site 525284002437 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 525284002438 Fructosamine kinase; Region: Fructosamin_kin; cl17579 525284002439 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 525284002440 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 525284002441 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 525284002442 HIGH motif; other site 525284002443 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 525284002444 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 525284002445 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 525284002446 active site 525284002447 KMSKS motif; other site 525284002448 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 525284002449 tRNA binding surface [nucleotide binding]; other site 525284002450 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 525284002451 Helix-hairpin-helix motif; Region: HHH; pfam00633 525284002452 Competence protein; Region: Competence; pfam03772 525284002453 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 525284002454 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 525284002455 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 525284002456 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 525284002457 Glycoprotease family; Region: Peptidase_M22; pfam00814 525284002458 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 525284002459 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525284002460 Coenzyme A binding pocket [chemical binding]; other site 525284002461 UGMP family protein; Validated; Region: PRK09604 525284002462 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 525284002463 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 525284002464 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525284002465 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 525284002466 catalytic core [active] 525284002467 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 525284002468 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 525284002469 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 525284002470 THF binding site; other site 525284002471 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 525284002472 substrate binding site [chemical binding]; other site 525284002473 THF binding site; other site 525284002474 zinc-binding site [ion binding]; other site 525284002475 potential frameshift: common BLAST hit: gi|283783392|ref|YP_003374146.1| methylenetetrahydrofolate reductase (NAD(P)H) 525284002476 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 525284002477 FAD binding site [chemical binding]; other site 525284002478 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 525284002479 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 525284002480 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 525284002481 metal binding triad; other site 525284002482 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 525284002483 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 525284002484 metal binding triad; other site 525284002485 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 525284002486 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 525284002487 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 525284002488 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 525284002489 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 525284002490 dihydroorotase; Validated; Region: pyrC; PRK09357 525284002491 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 525284002492 active site 525284002493 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 525284002494 active site 525284002495 dimer interface [polypeptide binding]; other site 525284002496 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 525284002497 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 525284002498 FAD binding pocket [chemical binding]; other site 525284002499 FAD binding motif [chemical binding]; other site 525284002500 phosphate binding motif [ion binding]; other site 525284002501 beta-alpha-beta structure motif; other site 525284002502 NAD binding pocket [chemical binding]; other site 525284002503 Iron coordination center [ion binding]; other site 525284002504 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 525284002505 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 525284002506 heterodimer interface [polypeptide binding]; other site 525284002507 active site 525284002508 FMN binding site [chemical binding]; other site 525284002509 homodimer interface [polypeptide binding]; other site 525284002510 substrate binding site [chemical binding]; other site 525284002511 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525284002512 active site 525284002513 elongation factor P; Validated; Region: PRK00529 525284002514 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 525284002515 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 525284002516 RNA binding site [nucleotide binding]; other site 525284002517 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 525284002518 RNA binding site [nucleotide binding]; other site 525284002519 transcription antitermination factor NusB; Region: nusB; TIGR01951 525284002520 putative RNA binding site [nucleotide binding]; other site 525284002521 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 525284002522 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 525284002523 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 525284002524 catalytic site [active] 525284002525 subunit interface [polypeptide binding]; other site 525284002526 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 525284002527 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 525284002528 ATP-grasp domain; Region: ATP-grasp_4; cl17255 525284002529 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 525284002530 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 525284002531 ATP-grasp domain; Region: ATP-grasp_4; cl17255 525284002532 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 525284002533 IMP binding site; other site 525284002534 dimer interface [polypeptide binding]; other site 525284002535 partial ornithine binding site; other site 525284002536 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 525284002537 active site 525284002538 dimer interface [polypeptide binding]; other site 525284002539 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 525284002540 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 525284002541 catalytic site [active] 525284002542 G-X2-G-X-G-K; other site 525284002543 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 525284002544 S-adenosylmethionine synthetase; Validated; Region: PRK05250 525284002545 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 525284002546 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 525284002547 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 525284002548 primosome assembly protein PriA; Provisional; Region: PRK14873 525284002549 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 525284002550 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 525284002551 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 525284002552 shikimate binding site; other site 525284002553 NAD(P) binding site [chemical binding]; other site 525284002554 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 525284002555 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 525284002556 Phosphoglycerate kinase; Region: PGK; pfam00162 525284002557 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 525284002558 substrate binding site [chemical binding]; other site 525284002559 hinge regions; other site 525284002560 ADP binding site [chemical binding]; other site 525284002561 catalytic site [active] 525284002562 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 525284002563 triosephosphate isomerase; Provisional; Region: PRK14565 525284002564 substrate binding site [chemical binding]; other site 525284002565 dimer interface [polypeptide binding]; other site 525284002566 catalytic triad [active] 525284002567 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525284002568 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 525284002569 active site 525284002570 motif I; other site 525284002571 motif II; other site 525284002572 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525284002573 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525284002574 salt bridge; other site 525284002575 non-specific DNA binding site [nucleotide binding]; other site 525284002576 sequence-specific DNA binding site [nucleotide binding]; other site 525284002577 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 525284002578 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 525284002579 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 525284002580 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 525284002581 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 525284002582 active site 525284002583 catalytic site [active] 525284002584 substrate binding site [chemical binding]; other site 525284002585 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 525284002586 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 525284002587 Dimer interface [polypeptide binding]; other site 525284002588 KilA-N domain; Region: KilA-N; pfam04383 525284002589 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 525284002590 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 525284002591 Cadmium resistance transporter; Region: Cad; pfam03596 525284002592 Fic/DOC family; Region: Fic; cl00960 525284002593 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 525284002594 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 525284002595 DNA binding residues [nucleotide binding] 525284002596 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 525284002597 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 525284002598 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 525284002599 putative active site [active] 525284002600 transaldolase; Provisional; Region: PRK03903 525284002601 catalytic residue [active] 525284002602 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 525284002603 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 525284002604 TPP-binding site [chemical binding]; other site 525284002605 dimer interface [polypeptide binding]; other site 525284002606 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 525284002607 PYR/PP interface [polypeptide binding]; other site 525284002608 dimer interface [polypeptide binding]; other site 525284002609 TPP binding site [chemical binding]; other site 525284002610 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 525284002611 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 525284002612 HTH domain; Region: HTH_11; pfam08279 525284002613 chaperone protein DnaJ; Provisional; Region: PRK14278 525284002614 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 525284002615 HSP70 interaction site [polypeptide binding]; other site 525284002616 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 525284002617 Zn binding sites [ion binding]; other site 525284002618 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 525284002619 dimer interface [polypeptide binding]; other site 525284002620 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 525284002621 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 525284002622 putative active site [active] 525284002623 substrate binding site [chemical binding]; other site 525284002624 putative cosubstrate binding site; other site 525284002625 catalytic site [active] 525284002626 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 525284002627 substrate binding site [chemical binding]; other site 525284002628 phosphoserine phosphatase SerB; Region: serB; TIGR00338 525284002629 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525284002630 motif II; other site 525284002631 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 525284002632 active site 525284002633 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 525284002634 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 525284002635 nucleotide binding site [chemical binding]; other site 525284002636 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 525284002637 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 525284002638 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525284002639 homodimer interface [polypeptide binding]; other site 525284002640 catalytic residue [active] 525284002641 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 525284002642 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525284002643 Walker A/P-loop; other site 525284002644 ATP binding site [chemical binding]; other site 525284002645 Q-loop/lid; other site 525284002646 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 525284002647 ABC transporter signature motif; other site 525284002648 Walker B; other site 525284002649 D-loop; other site 525284002650 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 525284002651 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 525284002652 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 525284002653 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 525284002654 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 525284002655 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14671 525284002656 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 525284002657 GIY-YIG motif/motif A; other site 525284002658 active site 525284002659 catalytic site [active] 525284002660 putative DNA binding site [nucleotide binding]; other site 525284002661 metal binding site [ion binding]; metal-binding site 525284002662 UvrB/uvrC motif; Region: UVR; pfam02151 525284002663 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 525284002664 Helix-hairpin-helix motif; Region: HHH; pfam00633 525284002665 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 525284002666 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 525284002667 active site 525284002668 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 525284002669 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 525284002670 acyl-activating enzyme (AAE) consensus motif; other site 525284002671 putative AMP binding site [chemical binding]; other site 525284002672 putative active site [active] 525284002673 putative CoA binding site [chemical binding]; other site 525284002674 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 525284002675 active site 525284002676 catalytic residues [active] 525284002677 metal binding site [ion binding]; metal-binding site 525284002678 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 525284002679 rRNA interaction site [nucleotide binding]; other site 525284002680 S8 interaction site; other site 525284002681 putative laminin-1 binding site; other site 525284002682 elongation factor Ts; Provisional; Region: tsf; PRK09377 525284002683 UBA/TS-N domain; Region: UBA; pfam00627 525284002684 Elongation factor TS; Region: EF_TS; pfam00889 525284002685 Elongation factor TS; Region: EF_TS; pfam00889 525284002686 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 525284002687 putative nucleotide binding site [chemical binding]; other site 525284002688 uridine monophosphate binding site [chemical binding]; other site 525284002689 homohexameric interface [polypeptide binding]; other site 525284002690 ribosome recycling factor; Reviewed; Region: frr; PRK00083 525284002691 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 525284002692 hinge region; other site 525284002693 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 525284002694 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 525284002695 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 525284002696 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 525284002697 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 525284002698 substrate binding site [chemical binding]; other site 525284002699 hexamer interface [polypeptide binding]; other site 525284002700 metal binding site [ion binding]; metal-binding site 525284002701 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 525284002702 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 525284002703 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 525284002704 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 525284002705 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 525284002706 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 525284002707 phosphopeptide binding site; other site 525284002708 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 525284002709 DNA binding residues [nucleotide binding] 525284002710 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 525284002711 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 525284002712 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525284002713 motif II; other site 525284002714 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 525284002715 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 525284002716 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 525284002717 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525284002718 ATP binding site [chemical binding]; other site 525284002719 putative Mg++ binding site [ion binding]; other site 525284002720 helicase superfamily c-terminal domain; Region: HELICc; smart00490 525284002721 nucleotide binding region [chemical binding]; other site 525284002722 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 525284002723 WYL domain; Region: WYL; pfam13280 525284002724 potential frameshift: common BLAST hit: gi|283783254|ref|YP_003374008.1| UTP--glucose-1-phosphate uridylyltransferase 525284002725 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525284002726 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525284002727 active site 525284002728 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 525284002729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284002730 dimer interface [polypeptide binding]; other site 525284002731 conserved gate region; other site 525284002732 putative PBP binding loops; other site 525284002733 ABC-ATPase subunit interface; other site 525284002734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284002735 dimer interface [polypeptide binding]; other site 525284002736 conserved gate region; other site 525284002737 ABC-ATPase subunit interface; other site 525284002738 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 525284002739 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 525284002740 substrate binding pocket [chemical binding]; other site 525284002741 membrane-bound complex binding site; other site 525284002742 hinge residues; other site 525284002743 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 525284002744 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 525284002745 Walker A/P-loop; other site 525284002746 ATP binding site [chemical binding]; other site 525284002747 Q-loop/lid; other site 525284002748 ABC transporter signature motif; other site 525284002749 Walker B; other site 525284002750 D-loop; other site 525284002751 H-loop/switch region; other site 525284002752 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 525284002753 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 525284002754 dimer interface [polypeptide binding]; other site 525284002755 anticodon binding site; other site 525284002756 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 525284002757 motif 1; other site 525284002758 dimer interface [polypeptide binding]; other site 525284002759 active site 525284002760 motif 2; other site 525284002761 GAD domain; Region: GAD; pfam02938 525284002762 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 525284002763 active site 525284002764 motif 3; other site 525284002765 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 525284002766 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 525284002767 dimer interface [polypeptide binding]; other site 525284002768 motif 1; other site 525284002769 active site 525284002770 motif 2; other site 525284002771 motif 3; other site 525284002772 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 525284002773 anticodon binding site; other site 525284002774 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 525284002775 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 525284002776 Domain of unknown function DUF59; Region: DUF59; pfam01883 525284002777 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 525284002778 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 525284002779 Walker A motif; other site 525284002780 Ligase N family; Region: LIGANc; smart00532 525284002781 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 525284002782 nucleotide binding pocket [chemical binding]; other site 525284002783 K-X-D-G motif; other site 525284002784 catalytic site [active] 525284002785 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 525284002786 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 525284002787 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 525284002788 Helix-hairpin-helix motif; Region: HHH; pfam00633 525284002789 helix-hairpin-helix signature motif; other site 525284002790 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 525284002791 Dimer interface [polypeptide binding]; other site 525284002792 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525284002793 binding surface 525284002794 TPR motif; other site 525284002795 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 525284002796 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 525284002797 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 525284002798 dimerization interface [polypeptide binding]; other site 525284002799 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 525284002800 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 525284002801 catalytic residue [active] 525284002802 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 525284002803 peroxiredoxin; Region: AhpC; TIGR03137 525284002804 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 525284002805 dimer interface [polypeptide binding]; other site 525284002806 decamer (pentamer of dimers) interface [polypeptide binding]; other site 525284002807 catalytic triad [active] 525284002808 peroxidatic and resolving cysteines [active] 525284002809 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 525284002810 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 525284002811 NAD binding site [chemical binding]; other site 525284002812 substrate binding site [chemical binding]; other site 525284002813 catalytic Zn binding site [ion binding]; other site 525284002814 tetramer interface [polypeptide binding]; other site 525284002815 structural Zn binding site [ion binding]; other site 525284002816 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 525284002817 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525284002818 active site 525284002819 Predicted membrane protein [Function unknown]; Region: COG3601 525284002820 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 525284002821 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 525284002822 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 525284002823 Walker A/P-loop; other site 525284002824 ATP binding site [chemical binding]; other site 525284002825 Q-loop/lid; other site 525284002826 ABC transporter signature motif; other site 525284002827 Walker B; other site 525284002828 D-loop; other site 525284002829 H-loop/switch region; other site 525284002830 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 525284002831 Walker A/P-loop; other site 525284002832 ATP binding site [chemical binding]; other site 525284002833 Q-loop/lid; other site 525284002834 ABC transporter signature motif; other site 525284002835 Walker B; other site 525284002836 D-loop; other site 525284002837 H-loop/switch region; other site 525284002838 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 525284002839 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 525284002840 recombination factor protein RarA; Reviewed; Region: PRK13342 525284002841 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525284002842 Walker A motif; other site 525284002843 ATP binding site [chemical binding]; other site 525284002844 Walker B motif; other site 525284002845 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 525284002846 DEAD-like helicases superfamily; Region: DEXDc; smart00487 525284002847 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525284002848 ATP binding site [chemical binding]; other site 525284002849 putative Mg++ binding site [ion binding]; other site 525284002850 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525284002851 nucleotide binding region [chemical binding]; other site 525284002852 ATP-binding site [chemical binding]; other site 525284002853 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 525284002854 bifunctional cytidylate kinase/GTPase Der; Reviewed; Region: PRK09518 525284002855 AAA domain; Region: AAA_17; pfam13207 525284002856 Cytidylate kinase; Region: Cytidylate_kin; pfam02224 525284002857 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 525284002858 G1 box; other site 525284002859 GTP/Mg2+ binding site [chemical binding]; other site 525284002860 Switch I region; other site 525284002861 G2 box; other site 525284002862 Switch II region; other site 525284002863 G3 box; other site 525284002864 G4 box; other site 525284002865 G5 box; other site 525284002866 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 525284002867 G1 box; other site 525284002868 GTP/Mg2+ binding site [chemical binding]; other site 525284002869 Switch I region; other site 525284002870 G2 box; other site 525284002871 G3 box; other site 525284002872 Switch II region; other site 525284002873 G4 box; other site 525284002874 G5 box; other site 525284002875 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 525284002876 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 525284002877 RNA binding surface [nucleotide binding]; other site 525284002878 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 525284002879 active site 525284002880 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 525284002881 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 525284002882 amphipathic channel; other site 525284002883 Asn-Pro-Ala signature motifs; other site 525284002884 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 525284002885 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 525284002886 purine monophosphate binding site [chemical binding]; other site 525284002887 dimer interface [polypeptide binding]; other site 525284002888 putative catalytic residues [active] 525284002889 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 525284002890 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525284002891 active site 525284002892 Preprotein translocase subunit; Region: YajC; cl00806 525284002893 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 525284002894 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525284002895 Walker A motif; other site 525284002896 ATP binding site [chemical binding]; other site 525284002897 Walker B motif; other site 525284002898 arginine finger; other site 525284002899 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 525284002900 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 525284002901 RuvA N terminal domain; Region: RuvA_N; pfam01330 525284002902 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 525284002903 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 525284002904 active site 525284002905 putative DNA-binding cleft [nucleotide binding]; other site 525284002906 dimer interface [polypeptide binding]; other site 525284002907 hypothetical protein; Validated; Region: PRK00110 525284002908 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 525284002909 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 525284002910 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 525284002911 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525284002912 active site 525284002913 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 525284002914 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 525284002915 active site 525284002916 (T/H)XGH motif; other site 525284002917 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 525284002918 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 525284002919 putative catalytic cysteine [active] 525284002920 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 525284002921 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 525284002922 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525284002923 catalytic residue [active] 525284002924 recombination regulator RecX; Reviewed; Region: recX; PRK00117 525284002925 recombinase A; Provisional; Region: recA; PRK09354 525284002926 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 525284002927 hexamer interface [polypeptide binding]; other site 525284002928 Walker A motif; other site 525284002929 ATP binding site [chemical binding]; other site 525284002930 Walker B motif; other site 525284002931 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 525284002932 Competence-damaged protein; Region: CinA; pfam02464 525284002933 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 525284002934 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 525284002935 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 525284002936 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 525284002937 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 525284002938 ATP-grasp domain; Region: ATP-grasp; pfam02222 525284002939 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 525284002940 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 525284002941 ATP binding site [chemical binding]; other site 525284002942 active site 525284002943 substrate binding site [chemical binding]; other site 525284002944 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 525284002945 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 525284002946 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 525284002947 dimerization interface [polypeptide binding]; other site 525284002948 ATP binding site [chemical binding]; other site 525284002949 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 525284002950 dimerization interface [polypeptide binding]; other site 525284002951 ATP binding site [chemical binding]; other site 525284002952 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 525284002953 putative active site [active] 525284002954 catalytic triad [active] 525284002955 amidophosphoribosyltransferase; Provisional; Region: PRK07272 525284002956 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 525284002957 active site 525284002958 tetramer interface [polypeptide binding]; other site 525284002959 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525284002960 active site 525284002961 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 525284002962 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 525284002963 dimerization interface [polypeptide binding]; other site 525284002964 putative ATP binding site [chemical binding]; other site 525284002965 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 525284002966 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 525284002967 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 525284002968 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 525284002969 Sulfatase; Region: Sulfatase; pfam00884 525284002970 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 525284002971 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 525284002972 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 525284002973 metal binding site 2 [ion binding]; metal-binding site 525284002974 putative DNA binding helix; other site 525284002975 metal binding site 1 [ion binding]; metal-binding site 525284002976 dimer interface [polypeptide binding]; other site 525284002977 structural Zn2+ binding site [ion binding]; other site 525284002978 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 525284002979 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 525284002980 NAD binding site [chemical binding]; other site 525284002981 ATP-grasp domain; Region: ATP-grasp; pfam02222 525284002982 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 525284002983 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525284002984 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 525284002985 Walker A/P-loop; other site 525284002986 ATP binding site [chemical binding]; other site 525284002987 Q-loop/lid; other site 525284002988 ABC transporter signature motif; other site 525284002989 Walker B; other site 525284002990 D-loop; other site 525284002991 H-loop/switch region; other site 525284002992 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 525284002993 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 525284002994 FtsX-like permease family; Region: FtsX; pfam02687 525284002995 potential frameshift: common BLAST hit: gi|283783315|ref|YP_003374069.1| putative oxygen-independent coproporphyrinogen III oxidase 525284002996 HemN C-terminal domain; Region: HemN_C; pfam06969 525284002997 Radical SAM superfamily; Region: Radical_SAM; pfam04055 525284002998 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525284002999 FeS/SAM binding site; other site 525284003000 GTP-binding protein LepA; Provisional; Region: PRK05433 525284003001 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 525284003002 G1 box; other site 525284003003 putative GEF interaction site [polypeptide binding]; other site 525284003004 GTP/Mg2+ binding site [chemical binding]; other site 525284003005 Switch I region; other site 525284003006 G2 box; other site 525284003007 G3 box; other site 525284003008 Switch II region; other site 525284003009 G4 box; other site 525284003010 G5 box; other site 525284003011 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 525284003012 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 525284003013 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 525284003014 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 525284003015 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 525284003016 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 525284003017 DNA-binding site [nucleotide binding]; DNA binding site 525284003018 UTRA domain; Region: UTRA; pfam07702 525284003019 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 525284003020 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 525284003021 transmembrane helices; other site 525284003022 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 525284003023 acetolactate synthase; Reviewed; Region: PRK08322 525284003024 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 525284003025 PYR/PP interface [polypeptide binding]; other site 525284003026 dimer interface [polypeptide binding]; other site 525284003027 TPP binding site [chemical binding]; other site 525284003028 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 525284003029 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 525284003030 TPP-binding site [chemical binding]; other site 525284003031 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 525284003032 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 525284003033 nucleotide binding site [chemical binding]; other site 525284003034 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 525284003035 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 525284003036 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 525284003037 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 525284003038 putative active site [active] 525284003039 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 525284003040 active site 525284003041 putative transporter; Provisional; Region: PRK03699 525284003042 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525284003043 putative substrate translocation pore; other site 525284003044 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 525284003045 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 525284003046 ligand binding site [chemical binding]; other site 525284003047 flexible hinge region; other site 525284003048 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 525284003049 non-specific DNA interactions [nucleotide binding]; other site 525284003050 DNA binding site [nucleotide binding] 525284003051 sequence specific DNA binding site [nucleotide binding]; other site 525284003052 putative cAMP binding site [chemical binding]; other site 525284003053 Cobalt transport protein; Region: CbiQ; cl00463 525284003054 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 525284003055 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 525284003056 Walker A/P-loop; other site 525284003057 ATP binding site [chemical binding]; other site 525284003058 Q-loop/lid; other site 525284003059 ABC transporter signature motif; other site 525284003060 Walker B; other site 525284003061 D-loop; other site 525284003062 H-loop/switch region; other site 525284003063 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 525284003064 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 525284003065 Walker A/P-loop; other site 525284003066 ATP binding site [chemical binding]; other site 525284003067 Q-loop/lid; other site 525284003068 ABC transporter signature motif; other site 525284003069 Walker B; other site 525284003070 D-loop; other site 525284003071 H-loop/switch region; other site 525284003072 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 525284003073 active site 525284003074 catalytic site [active] 525284003075 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 525284003076 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 525284003077 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 525284003078 putative active cleft [active] 525284003079 DNA primase, catalytic core; Region: dnaG; TIGR01391 525284003080 CHC2 zinc finger; Region: zf-CHC2; cl17510 525284003081 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 525284003082 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 525284003083 active site 525284003084 metal binding site [ion binding]; metal-binding site 525284003085 interdomain interaction site; other site 525284003086 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 525284003087 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 525284003088 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525284003089 Zn2+ binding site [ion binding]; other site 525284003090 Mg2+ binding site [ion binding]; other site 525284003091 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 525284003092 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 525284003093 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 525284003094 active site 525284003095 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 525284003096 dimer interface [polypeptide binding]; other site 525284003097 substrate binding site [chemical binding]; other site 525284003098 catalytic residues [active] 525284003099 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 525284003100 S-ribosylhomocysteinase; Provisional; Region: PRK02260 525284003101 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 525284003102 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 525284003103 Walker A/P-loop; other site 525284003104 ATP binding site [chemical binding]; other site 525284003105 Q-loop/lid; other site 525284003106 ABC transporter signature motif; other site 525284003107 Walker B; other site 525284003108 D-loop; other site 525284003109 H-loop/switch region; other site 525284003110 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 525284003111 Walker A/P-loop; other site 525284003112 ATP binding site [chemical binding]; other site 525284003113 Q-loop/lid; other site 525284003114 ABC transporter signature motif; other site 525284003115 Walker B; other site 525284003116 D-loop; other site 525284003117 H-loop/switch region; other site 525284003118 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 525284003119 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 525284003120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284003121 dimer interface [polypeptide binding]; other site 525284003122 conserved gate region; other site 525284003123 putative PBP binding loops; other site 525284003124 ABC-ATPase subunit interface; other site 525284003125 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 525284003126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284003127 dimer interface [polypeptide binding]; other site 525284003128 conserved gate region; other site 525284003129 putative PBP binding loops; other site 525284003130 ABC-ATPase subunit interface; other site 525284003131 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 525284003132 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 525284003133 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 525284003134 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 525284003135 active site 525284003136 multimer interface [polypeptide binding]; other site 525284003137 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 525284003138 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13152 525284003139 predicted active site [active] 525284003140 catalytic triad [active] 525284003141 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 525284003142 homodimer interface [polypeptide binding]; other site 525284003143 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 525284003144 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 525284003145 active site 525284003146 homodimer interface [polypeptide binding]; other site 525284003147 catalytic site [active] 525284003148 pantothenate kinase; Reviewed; Region: PRK13318 525284003149 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 525284003150 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 525284003151 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 525284003152 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 525284003153 glutaminase active site [active] 525284003154 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 525284003155 dimer interface [polypeptide binding]; other site 525284003156 active site 525284003157 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 525284003158 dimer interface [polypeptide binding]; other site 525284003159 active site 525284003160 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 525284003161 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 525284003162 Walker A/P-loop; other site 525284003163 ATP binding site [chemical binding]; other site 525284003164 Q-loop/lid; other site 525284003165 ABC transporter signature motif; other site 525284003166 Walker B; other site 525284003167 D-loop; other site 525284003168 H-loop/switch region; other site 525284003169 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 525284003170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284003171 dimer interface [polypeptide binding]; other site 525284003172 conserved gate region; other site 525284003173 putative PBP binding loops; other site 525284003174 ABC-ATPase subunit interface; other site 525284003175 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 525284003176 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 525284003177 substrate binding pocket [chemical binding]; other site 525284003178 membrane-bound complex binding site; other site 525284003179 hinge residues; other site 525284003180 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 525284003181 SmpB-tmRNA interface; other site 525284003182 CHAP domain; Region: CHAP; pfam05257 525284003183 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 525284003184 FtsX-like permease family; Region: FtsX; pfam02687 525284003185 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 525284003186 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525284003187 Walker A/P-loop; other site 525284003188 ATP binding site [chemical binding]; other site 525284003189 Q-loop/lid; other site 525284003190 ABC transporter signature motif; other site 525284003191 Walker B; other site 525284003192 D-loop; other site 525284003193 H-loop/switch region; other site 525284003194 peptide chain release factor 2; Validated; Region: prfB; PRK00578 525284003195 This domain is found in peptide chain release factors; Region: PCRF; smart00937 525284003196 RF-1 domain; Region: RF-1; pfam00472 525284003197 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 525284003198 active site 525284003199 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 525284003200 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 525284003201 active site 525284003202 Zn binding site [ion binding]; other site 525284003203 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 525284003204 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 525284003205 dimer interface [polypeptide binding]; other site 525284003206 ssDNA binding site [nucleotide binding]; other site 525284003207 tetramer (dimer of dimers) interface [polypeptide binding]; other site 525284003208 prolyl-tRNA synthetase; Provisional; Region: PRK09194 525284003209 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 525284003210 dimer interface [polypeptide binding]; other site 525284003211 motif 1; other site 525284003212 active site 525284003213 motif 2; other site 525284003214 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 525284003215 putative deacylase active site [active] 525284003216 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 525284003217 active site 525284003218 motif 3; other site 525284003219 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 525284003220 anticodon binding site; other site 525284003221 PIF1-like helicase; Region: PIF1; pfam05970 525284003222 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525284003223 Walker A motif; other site 525284003224 ATP binding site [chemical binding]; other site 525284003225 Walker B motif; other site 525284003226 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 525284003227 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 525284003228 catalytic site [active] 525284003229 putative active site [active] 525284003230 putative substrate binding site [chemical binding]; other site 525284003231 dimer interface [polypeptide binding]; other site 525284003232 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 525284003233 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 525284003234 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 525284003235 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 525284003236 active site 525284003237 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 525284003238 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 525284003239 Mg++ binding site [ion binding]; other site 525284003240 putative catalytic motif [active] 525284003241 substrate binding site [chemical binding]; other site 525284003242 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 525284003243 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 525284003244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525284003245 S-adenosylmethionine binding site [chemical binding]; other site 525284003246 peptide chain release factor 1; Validated; Region: prfA; PRK00591 525284003247 PCRF domain; Region: PCRF; pfam03462 525284003248 RF-1 domain; Region: RF-1; pfam00472 525284003249 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 525284003250 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 525284003251 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 525284003252 5S rRNA interface [nucleotide binding]; other site 525284003253 CTC domain interface [polypeptide binding]; other site 525284003254 L16 interface [polypeptide binding]; other site 525284003255 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 525284003256 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 525284003257 acyl-activating enzyme (AAE) consensus motif; other site 525284003258 putative AMP binding site [chemical binding]; other site 525284003259 putative active site [active] 525284003260 putative CoA binding site [chemical binding]; other site 525284003261 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 525284003262 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 525284003263 GTPase Era; Reviewed; Region: era; PRK00089 525284003264 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 525284003265 G1 box; other site 525284003266 GTP/Mg2+ binding site [chemical binding]; other site 525284003267 Switch I region; other site 525284003268 G2 box; other site 525284003269 Switch II region; other site 525284003270 G3 box; other site 525284003271 G4 box; other site 525284003272 G5 box; other site 525284003273 KH domain; Region: KH_2; pfam07650 525284003274 FOG: CBS domain [General function prediction only]; Region: COG0517 525284003275 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 525284003276 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 525284003277 metal-binding heat shock protein; Provisional; Region: PRK00016 525284003278 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 525284003279 PhoH-like protein; Region: PhoH; pfam02562 525284003280 potential frameshift: common BLAST hit: gi|283783328|ref|YP_003374082.1| histidine triad domain protein 525284003281 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 525284003282 nucleotide binding site/active site [active] 525284003283 HIT family signature motif; other site 525284003284 catalytic residue [active] 525284003285 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 525284003286 nucleotide binding site/active site [active] 525284003287 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 525284003288 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 525284003289 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 525284003290 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 525284003291 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 525284003292 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 525284003293 EamA-like transporter family; Region: EamA; pfam00892 525284003294 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 525284003295 EamA-like transporter family; Region: EamA; pfam00892 525284003296 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 525284003297 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 525284003298 LytTr DNA-binding domain; Region: LytTR; pfam04397 525284003299 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 525284003300 catalytic core [active] 525284003301 Oligomerisation domain; Region: Oligomerisation; pfam02410 525284003302 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 525284003303 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 525284003304 Substrate binding site; other site 525284003305 Mg++ binding site; other site 525284003306 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 525284003307 active site 525284003308 substrate binding site [chemical binding]; other site 525284003309 CoA binding site [chemical binding]; other site 525284003310 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 525284003311 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 525284003312 domain interfaces; other site 525284003313 active site 525284003314 excinuclease ABC subunit B; Provisional; Region: PRK05298 525284003315 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525284003316 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525284003317 nucleotide binding region [chemical binding]; other site 525284003318 ATP-binding site [chemical binding]; other site 525284003319 Ultra-violet resistance protein B; Region: UvrB; pfam12344 525284003320 UvrB/uvrC motif; Region: UVR; pfam02151 525284003321 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 525284003322 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 525284003323 CoA-binding site [chemical binding]; other site 525284003324 ATP-binding [chemical binding]; other site 525284003325 TM2 domain; Region: TM2; pfam05154 525284003326 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 525284003327 active site 525284003328 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525284003329 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 525284003330 Coenzyme A binding pocket [chemical binding]; other site 525284003331 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 525284003332 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 525284003333 RNA binding site [nucleotide binding]; other site 525284003334 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 525284003335 RNA binding site [nucleotide binding]; other site 525284003336 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 525284003337 RNA binding site [nucleotide binding]; other site 525284003338 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 525284003339 RNA binding site [nucleotide binding]; other site 525284003340 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 525284003341 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 525284003342 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 525284003343 homodimer interface [polypeptide binding]; other site 525284003344 NADP binding site [chemical binding]; other site 525284003345 substrate binding site [chemical binding]; other site 525284003346 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 525284003347 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 525284003348 intersubunit interface [polypeptide binding]; other site 525284003349 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 525284003350 glycogen branching enzyme; Provisional; Region: PRK05402 525284003351 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 525284003352 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 525284003353 active site 525284003354 catalytic site [active] 525284003355 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 525284003356 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 525284003357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525284003358 active site 525284003359 phosphorylation site [posttranslational modification] 525284003360 intermolecular recognition site; other site 525284003361 dimerization interface [polypeptide binding]; other site 525284003362 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 525284003363 DNA binding site [nucleotide binding] 525284003364 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525284003365 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 525284003366 dimerization interface [polypeptide binding]; other site 525284003367 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525284003368 dimer interface [polypeptide binding]; other site 525284003369 phosphorylation site [posttranslational modification] 525284003370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525284003371 ATP binding site [chemical binding]; other site 525284003372 Mg2+ binding site [ion binding]; other site 525284003373 G-X-G motif; other site 525284003374 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525284003375 active site 525284003376 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 525284003377 Eukaryotic phosphomannomutase; Region: PMM; cl17107 525284003378 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 525284003379 potential frameshift: common BLAST hit: gi|283783072|ref|YP_003373826.1| putative ATP synthase F0, A subunit 525284003380 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525284003381 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 525284003382 Transcriptional regulator [Transcription]; Region: LytR; COG1316 525284003383 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 525284003384 Transcription factor WhiB; Region: Whib; pfam02467 525284003385 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 525284003386 PAS fold; Region: PAS_4; pfam08448 525284003387 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 525284003388 Histidine kinase; Region: HisKA_2; pfam07568 525284003389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525284003390 ATP binding site [chemical binding]; other site 525284003391 Mg2+ binding site [ion binding]; other site 525284003392 G-X-G motif; other site 525284003393 YcfA-like protein; Region: YcfA; cl00752 525284003394 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 525284003395 HicB family; Region: HicB; pfam05534 525284003396 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 525284003397 putative substrate binding pocket [chemical binding]; other site 525284003398 AC domain interface; other site 525284003399 catalytic triad [active] 525284003400 AB domain interface; other site 525284003401 interchain disulfide; other site 525284003402 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 525284003403 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 525284003404 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 525284003405 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 525284003406 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 525284003407 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 525284003408 active site 525284003409 NAD binding site [chemical binding]; other site 525284003410 metal binding site [ion binding]; metal-binding site 525284003411 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 525284003412 Predicted membrane protein [Function unknown]; Region: COG1511 525284003413 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 525284003414 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 525284003415 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 525284003416 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 525284003417 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525284003418 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525284003419 Walker A/P-loop; other site 525284003420 ATP binding site [chemical binding]; other site 525284003421 Q-loop/lid; other site 525284003422 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 525284003423 classical (c) SDRs; Region: SDR_c; cd05233 525284003424 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 525284003425 NAD(P) binding site [chemical binding]; other site 525284003426 active site 525284003427 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525284003428 Predicted permease [General function prediction only]; Region: COG2056 525284003429 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 525284003430 LemA family; Region: LemA; cl00742 525284003431 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 525284003432 potential frameshift: common BLAST hit: gi|146320586|ref|YP_001200297.1| cobalt ABC transporter permease protein 525284003433 Cobalt transport protein; Region: CbiQ; cl00463 525284003434 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 525284003435 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 525284003436 Walker A/P-loop; other site 525284003437 ATP binding site [chemical binding]; other site 525284003438 Q-loop/lid; other site 525284003439 ABC transporter signature motif; other site 525284003440 Walker B; other site 525284003441 D-loop; other site 525284003442 H-loop/switch region; other site 525284003443 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 525284003444 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 525284003445 Walker A/P-loop; other site 525284003446 ATP binding site [chemical binding]; other site 525284003447 Q-loop/lid; other site 525284003448 ABC transporter signature motif; other site 525284003449 Walker B; other site 525284003450 D-loop; other site 525284003451 H-loop/switch region; other site 525284003452 potential frameshift: common BLAST hit: gi|283783035|ref|YP_003373789.1| ABC transporter, ATP-binding protein 525284003453 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 525284003454 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525284003455 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525284003456 Walker A/P-loop; other site 525284003457 ATP binding site [chemical binding]; other site 525284003458 Q-loop/lid; other site 525284003459 ABC transporter signature motif; other site 525284003460 Walker B; other site 525284003461 D-loop; other site 525284003462 H-loop/switch region; other site 525284003463 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 525284003464 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 525284003465 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 525284003466 dimer interface [polypeptide binding]; other site 525284003467 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525284003468 catalytic residue [active] 525284003469 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 525284003470 serine O-acetyltransferase; Region: cysE; TIGR01172 525284003471 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 525284003472 trimer interface [polypeptide binding]; other site 525284003473 active site 525284003474 substrate binding site [chemical binding]; other site 525284003475 CoA binding site [chemical binding]; other site 525284003476 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 525284003477 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525284003478 Coenzyme A binding pocket [chemical binding]; other site 525284003479 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 525284003480 serine/threonine transporter SstT; Provisional; Region: PRK13628 525284003481 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 525284003482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525284003483 Major Facilitator Superfamily; Region: MFS_1; pfam07690 525284003484 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 525284003485 ABC-2 type transporter; Region: ABC2_membrane; cl17235 525284003486 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525284003487 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 525284003488 Walker A/P-loop; other site 525284003489 ATP binding site [chemical binding]; other site 525284003490 Q-loop/lid; other site 525284003491 ABC transporter signature motif; other site 525284003492 Walker B; other site 525284003493 D-loop; other site 525284003494 H-loop/switch region; other site 525284003495 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 525284003496 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 525284003497 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 525284003498 AAA domain; Region: AAA_14; pfam13173 525284003499 RelB antitoxin; Region: RelB; cl01171 525284003500 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525284003501 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525284003502 ABC transporter signature motif; other site 525284003503 ABC transporter signature motif; other site 525284003504 Walker B; other site 525284003505 Walker B; other site 525284003506 D-loop; other site 525284003507 H-loop/switch region; other site 525284003508 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525284003509 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 525284003510 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 525284003511 RelB antitoxin; Region: RelB; cl01171 525284003512 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 525284003513 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525284003514 non-specific DNA binding site [nucleotide binding]; other site 525284003515 salt bridge; other site 525284003516 sequence-specific DNA binding site [nucleotide binding]; other site 525284003517 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 525284003518 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 525284003519 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525284003520 non-specific DNA binding site [nucleotide binding]; other site 525284003521 salt bridge; other site 525284003522 sequence-specific DNA binding site [nucleotide binding]; other site 525284003523 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525284003524 Coenzyme A binding pocket [chemical binding]; other site 525284003525 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 525284003526 nudix motif; other site 525284003527 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 525284003528 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 525284003529 putative active site [active] 525284003530 putative NTP binding site [chemical binding]; other site 525284003531 putative nucleic acid binding site [nucleotide binding]; other site 525284003532 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 525284003533 Divergent AAA domain; Region: AAA_4; pfam04326 525284003534 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 525284003535 HTH domain; Region: HTH_11; cl17392 525284003536 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 525284003537 RelB antitoxin; Region: RelB; cl01171 525284003538 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 525284003539 Cadmium resistance transporter; Region: Cad; pfam03596 525284003540 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 525284003541 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 525284003542 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 525284003543 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 525284003544 TRAM domain; Region: TRAM; pfam01938 525284003545 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 525284003546 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 525284003547 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 525284003548 putative active site [active] 525284003549 putative catalytic site [active] 525284003550 putative DNA binding site [nucleotide binding]; other site 525284003551 putative phosphate binding site [ion binding]; other site 525284003552 metal binding site A [ion binding]; metal-binding site 525284003553 putative AP binding site [nucleotide binding]; other site 525284003554 putative metal binding site B [ion binding]; other site 525284003555 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 525284003556 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 525284003557 Walker A/P-loop; other site 525284003558 ATP binding site [chemical binding]; other site 525284003559 Q-loop/lid; other site 525284003560 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 525284003561 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 525284003562 ABC transporter signature motif; other site 525284003563 Walker B; other site 525284003564 D-loop; other site 525284003565 H-loop/switch region; other site 525284003566 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 525284003567 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 525284003568 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 525284003569 Walker A/P-loop; other site 525284003570 ATP binding site [chemical binding]; other site 525284003571 Q-loop/lid; other site 525284003572 ABC transporter signature motif; other site 525284003573 Walker B; other site 525284003574 D-loop; other site 525284003575 H-loop/switch region; other site 525284003576 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 525284003577 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 525284003578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284003579 dimer interface [polypeptide binding]; other site 525284003580 conserved gate region; other site 525284003581 putative PBP binding loops; other site 525284003582 ABC-ATPase subunit interface; other site 525284003583 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 525284003584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284003585 dimer interface [polypeptide binding]; other site 525284003586 conserved gate region; other site 525284003587 putative PBP binding loops; other site 525284003588 ABC-ATPase subunit interface; other site 525284003589 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 525284003590 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 525284003591 CTP synthetase; Validated; Region: pyrG; PRK05380 525284003592 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 525284003593 Catalytic site [active] 525284003594 active site 525284003595 UTP binding site [chemical binding]; other site 525284003596 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 525284003597 active site 525284003598 putative oxyanion hole; other site 525284003599 catalytic triad [active] 525284003600 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 525284003601 Dehydroquinase class II; Region: DHquinase_II; pfam01220 525284003602 trimer interface [polypeptide binding]; other site 525284003603 active site 525284003604 dimer interface [polypeptide binding]; other site 525284003605 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 525284003606 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 525284003607 ADP binding site [chemical binding]; other site 525284003608 magnesium binding site [ion binding]; other site 525284003609 putative shikimate binding site; other site 525284003610 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 525284003611 active site 525284003612 dimer interface [polypeptide binding]; other site 525284003613 metal binding site [ion binding]; metal-binding site 525284003614 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 525284003615 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 525284003616 Tetramer interface [polypeptide binding]; other site 525284003617 active site 525284003618 FMN-binding site [chemical binding]; other site 525284003619 YceG-like family; Region: YceG; pfam02618 525284003620 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 525284003621 dimerization interface [polypeptide binding]; other site 525284003622 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 525284003623 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 525284003624 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 525284003625 motif 1; other site 525284003626 active site 525284003627 motif 2; other site 525284003628 motif 3; other site 525284003629 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 525284003630 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 525284003631 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 525284003632 catalytic core [active] 525284003633 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 525284003634 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 525284003635 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 525284003636 dimer interface [polypeptide binding]; other site 525284003637 active site 525284003638 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 525284003639 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 525284003640 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 525284003641 RNA binding surface [nucleotide binding]; other site 525284003642 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525284003643 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 525284003644 Walker A/P-loop; other site 525284003645 ATP binding site [chemical binding]; other site 525284003646 Q-loop/lid; other site 525284003647 ABC transporter signature motif; other site 525284003648 Walker B; other site 525284003649 D-loop; other site 525284003650 H-loop/switch region; other site 525284003651 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 525284003652 FtsX-like permease family; Region: FtsX; pfam02687 525284003653 Domain of unknown function (DUF4418); Region: DUF4418; pfam14387 525284003654 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 525284003655 Part of AAA domain; Region: AAA_19; pfam13245 525284003656 Family description; Region: UvrD_C_2; pfam13538 525284003657 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525284003658 active site 525284003659 putative acyltransferase; Provisional; Region: PRK05790 525284003660 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 525284003661 dimer interface [polypeptide binding]; other site 525284003662 active site 525284003663 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 525284003664 homodimer interface [polypeptide binding]; other site 525284003665 catalytic residues [active] 525284003666 NAD binding site [chemical binding]; other site 525284003667 substrate binding pocket [chemical binding]; other site 525284003668 flexible flap; other site 525284003669 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 525284003670 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 525284003671 dimer interface [polypeptide binding]; other site 525284003672 active site 525284003673 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 525284003674 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 525284003675 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 525284003676 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 525284003677 synthetase active site [active] 525284003678 NTP binding site [chemical binding]; other site 525284003679 metal binding site [ion binding]; metal-binding site 525284003680 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 525284003681 active site 525284003682 catalytic site [active] 525284003683 Cna protein B-type domain; Region: Cna_B; pfam05738 525284003684 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 525284003685 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 525284003686 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 525284003687 P-loop; other site 525284003688 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 525284003689 Magnesium ion binding site [ion binding]; other site 525284003690 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 525284003691 Magnesium ion binding site [ion binding]; other site 525284003692 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 525284003693 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 525284003694 active site 525284003695 DNA binding site [nucleotide binding] 525284003696 Int/Topo IB signature motif; other site 525284003697 Prephenate dehydrogenase; Region: PDH; pfam02153 525284003698 prephenate dehydrogenase; Validated; Region: PRK08507 525284003699 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 525284003700 Prephenate dehydratase; Region: PDT; pfam00800 525284003701 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 525284003702 putative L-Phe binding site [chemical binding]; other site 525284003703 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 525284003704 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 525284003705 G1 box; other site 525284003706 putative GEF interaction site [polypeptide binding]; other site 525284003707 GTP/Mg2+ binding site [chemical binding]; other site 525284003708 Switch I region; other site 525284003709 G2 box; other site 525284003710 G3 box; other site 525284003711 Switch II region; other site 525284003712 G4 box; other site 525284003713 G5 box; other site 525284003714 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 525284003715 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 525284003716 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 525284003717 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 525284003718 Walker A/P-loop; other site 525284003719 ATP binding site [chemical binding]; other site 525284003720 Q-loop/lid; other site 525284003721 ABC transporter signature motif; other site 525284003722 Walker B; other site 525284003723 D-loop; other site 525284003724 H-loop/switch region; other site 525284003725 FeS assembly protein SufD; Region: sufD; TIGR01981 525284003726 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 525284003727 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 525284003728 FeS assembly protein SufB; Region: sufB; TIGR01980 525284003729 RelB antitoxin; Region: RelB; cl01171 525284003730 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 525284003731 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 525284003732 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 525284003733 active site 525284003734 DNA binding site [nucleotide binding] 525284003735 Int/Topo IB signature motif; other site 525284003736 ribonuclease III; Reviewed; Region: rnc; PRK00102 525284003737 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 525284003738 dimerization interface [polypeptide binding]; other site 525284003739 active site 525284003740 metal binding site [ion binding]; metal-binding site 525284003741 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 525284003742 dsRNA binding site [nucleotide binding]; other site 525284003743 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 525284003744 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 525284003745 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 525284003746 active site 525284003747 KMSKS motif; other site 525284003748 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 525284003749 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 525284003750 active site 525284003751 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 525284003752 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 525284003753 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 525284003754 active site 525284003755 HIGH motif; other site 525284003756 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 525284003757 KMSKS motif; other site 525284003758 tRNA binding surface [nucleotide binding]; other site 525284003759 anticodon binding site; other site 525284003760 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 525284003761 signal recognition particle protein; Provisional; Region: PRK10867 525284003762 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 525284003763 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 525284003764 P loop; other site 525284003765 GTP binding site [chemical binding]; other site 525284003766 Signal peptide binding domain; Region: SRP_SPB; pfam02978 525284003767 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 525284003768 putative catalytic site [active] 525284003769 putative metal binding site [ion binding]; other site 525284003770 putative phosphate binding site [ion binding]; other site 525284003771 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 525284003772 hypothetical protein; Provisional; Region: PRK02821 525284003773 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 525284003774 G-X-X-G motif; other site 525284003775 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 525284003776 RimM N-terminal domain; Region: RimM; pfam01782 525284003777 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 525284003778 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 525284003779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525284003780 S-adenosylmethionine binding site [chemical binding]; other site 525284003781 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 525284003782 active site 525284003783 tetramer interface [polypeptide binding]; other site 525284003784 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 525284003785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525284003786 putative substrate translocation pore; other site 525284003787 putative kinase; Provisional; Region: PRK09954 525284003788 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 525284003789 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 525284003790 substrate binding site [chemical binding]; other site 525284003791 ATP binding site [chemical binding]; other site 525284003792 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 525284003793 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 525284003794 generic binding surface I; other site 525284003795 generic binding surface II; other site 525284003796 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525284003797 ATP binding site [chemical binding]; other site 525284003798 putative Mg++ binding site [ion binding]; other site 525284003799 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525284003800 nucleotide binding region [chemical binding]; other site 525284003801 ATP-binding site [chemical binding]; other site 525284003802 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 525284003803 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 525284003804 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 525284003805 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 525284003806 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 525284003807 homotetramer interface [polypeptide binding]; other site 525284003808 FMN binding site [chemical binding]; other site 525284003809 homodimer contacts [polypeptide binding]; other site 525284003810 putative active site [active] 525284003811 putative substrate binding site [chemical binding]; other site 525284003812 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 525284003813 diphosphomevalonate decarboxylase; Region: PLN02407 525284003814 mevalonate kinase; Region: mevalon_kin; TIGR00549 525284003815 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 525284003816 amidase; Validated; Region: PRK06565 525284003817 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 525284003818 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 525284003819 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 525284003820 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 525284003821 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 525284003822 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 525284003823 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 525284003824 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 525284003825 dimer interface [polypeptide binding]; other site 525284003826 ssDNA binding site [nucleotide binding]; other site 525284003827 tetramer (dimer of dimers) interface [polypeptide binding]; other site 525284003828 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 525284003829 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 525284003830 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 525284003831 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525284003832 active site 525284003833 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 525284003834 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 525284003835 substrate binding site [chemical binding]; other site 525284003836 dimer interface [polypeptide binding]; other site 525284003837 ATP binding site [chemical binding]; other site 525284003838 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 525284003839 hypothetical protein; Validated; Region: PRK00194 525284003840 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 525284003841 23S rRNA binding site [nucleotide binding]; other site 525284003842 L21 binding site [polypeptide binding]; other site 525284003843 L13 binding site [polypeptide binding]; other site 525284003844 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 525284003845 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 525284003846 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 525284003847 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 525284003848 Thiamine pyrophosphokinase; Region: TPK; cd07995 525284003849 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 525284003850 active site 525284003851 dimerization interface [polypeptide binding]; other site 525284003852 thiamine binding site [chemical binding]; other site 525284003853 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 525284003854 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 525284003855 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 525284003856 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 525284003857 putative deacylase active site [active] 525284003858 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 525284003859 active site 525284003860 catalytic residues [active] 525284003861 P-loop containing region of AAA domain; Region: AAA_29; cl17516 525284003862 Zeta toxin; Region: Zeta_toxin; pfam06414 525284003863 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525284003864 non-specific DNA binding site [nucleotide binding]; other site 525284003865 salt bridge; other site 525284003866 sequence-specific DNA binding site [nucleotide binding]; other site 525284003867 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 525284003868 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525284003869 NAD(P) binding site [chemical binding]; other site 525284003870 active site 525284003871 MarR family; Region: MarR_2; pfam12802 525284003872 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 525284003873 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 525284003874 nucleotide binding site [chemical binding]; other site 525284003875 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 525284003876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284003877 dimer interface [polypeptide binding]; other site 525284003878 conserved gate region; other site 525284003879 putative PBP binding loops; other site 525284003880 ABC-ATPase subunit interface; other site 525284003881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284003882 dimer interface [polypeptide binding]; other site 525284003883 conserved gate region; other site 525284003884 putative PBP binding loops; other site 525284003885 ABC-ATPase subunit interface; other site 525284003886 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 525284003887 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 525284003888 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 525284003889 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 525284003890 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 525284003891 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 525284003892 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 525284003893 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 525284003894 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 525284003895 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 525284003896 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 525284003897 dimer interface [polypeptide binding]; other site 525284003898 active site 525284003899 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 525284003900 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 525284003901 active site 525284003902 catalytic site [active] 525284003903 substrate binding site [chemical binding]; other site 525284003904 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 525284003905 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 525284003906 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 525284003907 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 525284003908 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 525284003909 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 525284003910 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 525284003911 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 525284003912 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 525284003913 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 525284003914 putative substrate binding site [chemical binding]; other site 525284003915 putative ATP binding site [chemical binding]; other site 525284003916 proline aminopeptidase P II; Provisional; Region: PRK10879 525284003917 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 525284003918 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 525284003919 active site 525284003920 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 525284003921 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 525284003922 Zn binding site [ion binding]; other site 525284003923 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 525284003924 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 525284003925 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 525284003926 Major Facilitator Superfamily; Region: MFS_1; pfam07690 525284003927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 525284003928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525284003929 GA module; Region: GA; pfam01468 525284003930 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525284003931 Coenzyme A binding pocket [chemical binding]; other site 525284003932 Part of AAA domain; Region: AAA_19; pfam13245 525284003933 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 525284003934 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 525284003935 Family description; Region: UvrD_C_2; pfam13538 525284003936 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 525284003937 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 525284003938 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 525284003939 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 525284003940 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 525284003941 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 525284003942 active site 525284003943 catalytic site [active] 525284003944 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 525284003945 AAA domain; Region: AAA_14; pfam13173 525284003946 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 525284003947 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 525284003948 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 525284003949 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 525284003950 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 525284003951 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 525284003952 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 525284003953 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 525284003954 DNA binding site [nucleotide binding] 525284003955 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 525284003956 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 525284003957 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 525284003958 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 525284003959 RPB1 interaction site [polypeptide binding]; other site 525284003960 RPB10 interaction site [polypeptide binding]; other site 525284003961 RPB11 interaction site [polypeptide binding]; other site 525284003962 RPB3 interaction site [polypeptide binding]; other site 525284003963 RPB12 interaction site [polypeptide binding]; other site 525284003964 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 525284003965 EamA-like transporter family; Region: EamA; pfam00892 525284003966 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 525284003967 EamA-like transporter family; Region: EamA; pfam00892 525284003968 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 525284003969 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525284003970 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525284003971 Q-loop/lid; other site 525284003972 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 525284003973 RNA/DNA hybrid binding site [nucleotide binding]; other site 525284003974 active site 525284003975 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 525284003976 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 525284003977 Catalytic site [active] 525284003978 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 525284003979 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 525284003980 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 525284003981 Walker A/P-loop; other site 525284003982 ATP binding site [chemical binding]; other site 525284003983 Q-loop/lid; other site 525284003984 ABC transporter signature motif; other site 525284003985 Walker B; other site 525284003986 D-loop; other site 525284003987 H-loop/switch region; other site 525284003988 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 525284003989 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 525284003990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284003991 dimer interface [polypeptide binding]; other site 525284003992 conserved gate region; other site 525284003993 putative PBP binding loops; other site 525284003994 ABC-ATPase subunit interface; other site 525284003995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284003996 dimer interface [polypeptide binding]; other site 525284003997 conserved gate region; other site 525284003998 putative PBP binding loops; other site 525284003999 ABC-ATPase subunit interface; other site 525284004000 ykoK leader; HMPREF0421_nc20012 525284004001 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 525284004002 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 525284004003 active site 525284004004 dimer interface [polypeptide binding]; other site 525284004005 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 525284004006 dimer interface [polypeptide binding]; other site 525284004007 active site 525284004008 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 525284004009 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 525284004010 active site 525284004011 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 525284004012 Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E; Region: Flavi_E_C; cl17686 525284004013 homodimer interface [polypeptide binding]; other site 525284004014 low pH domain interface [polypeptide binding]; other site 525284004015 low pH trimer interface [polypeptide binding]; other site 525284004016 Rib/alpha-like repeat; Region: Rib; cl07159 525284004017 Rib/alpha-like repeat; Region: Rib; pfam08428 525284004018 Rib/alpha-like repeat; Region: Rib; cl07159 525284004019 Rib/alpha-like repeat; Region: Rib; pfam08428 525284004020 Rib/alpha-like repeat; Region: Rib; cl07159 525284004021 Rib/alpha-like repeat; Region: Rib; cl07159 525284004022 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 525284004023 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 525284004024 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 525284004025 active site 525284004026 Ca binding site [ion binding]; other site 525284004027 catalytic site [active] 525284004028 Aamy_C domain; Region: Aamy_C; smart00632 525284004029 Carbohydrate binding domain; Region: CBM_25; smart01066 525284004030 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 525284004031 carbohydrate binding site [chemical binding]; other site 525284004032 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 525284004033 carbohydrate binding site [chemical binding]; other site 525284004034 pullulanase, type I; Region: pulA_typeI; TIGR02104 525284004035 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 525284004036 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 525284004037 Ca binding site [ion binding]; other site 525284004038 active site 525284004039 catalytic site [active] 525284004040 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 525284004041 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 525284004042 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 525284004043 phosphate binding site [ion binding]; other site 525284004044 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 525284004045 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 525284004046 putative active site [active] 525284004047 putative catalytic site [active] 525284004048 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 525284004049 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 525284004050 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 525284004051 putative NAD(P) binding site [chemical binding]; other site 525284004052 active site 525284004053 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 525284004054 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 525284004055 active site 525284004056 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 525284004057 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 525284004058 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 525284004059 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 525284004060 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 525284004061 ATP-grasp domain; Region: ATP-grasp_4; cl17255 525284004062 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 525284004063 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 525284004064 carboxyltransferase (CT) interaction site; other site 525284004065 biotinylation site [posttranslational modification]; other site 525284004066 BioY family; Region: BioY; pfam02632 525284004067 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 525284004068 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 525284004069 active site 525284004070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 525284004071 Protein of unknown function, DUF606; Region: DUF606; pfam04657 525284004072 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 525284004073 Transcriptional regulators [Transcription]; Region: PurR; COG1609 525284004074 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 525284004075 DNA binding site [nucleotide binding] 525284004076 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 525284004077 ligand binding site [chemical binding]; other site 525284004078 dimerization interface [polypeptide binding]; other site 525284004079 AIPR protein; Region: AIPR; pfam10592 525284004080 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 525284004081 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 525284004082 tetramer interface [polypeptide binding]; other site 525284004083 active site 525284004084 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 525284004085 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 525284004086 TM-ABC transporter signature motif; other site 525284004087 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 525284004088 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 525284004089 TM-ABC transporter signature motif; other site 525284004090 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 525284004091 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 525284004092 Walker A/P-loop; other site 525284004093 ATP binding site [chemical binding]; other site 525284004094 Q-loop/lid; other site 525284004095 ABC transporter signature motif; other site 525284004096 Walker B; other site 525284004097 D-loop; other site 525284004098 H-loop/switch region; other site 525284004099 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 525284004100 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 525284004101 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 525284004102 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 525284004103 D-xylulose kinase; Region: XylB; TIGR01312 525284004104 nucleotide binding site [chemical binding]; other site 525284004105 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 525284004106 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 525284004107 Domain of unknown function (DUF386); Region: DUF386; cl01047 525284004108 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 525284004109 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 525284004110 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 525284004111 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 525284004112 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 525284004113 beta-phosphoglucomutase; Region: bPGM; TIGR01990 525284004114 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525284004115 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 525284004116 EamA-like transporter family; Region: EamA; pfam00892 525284004117 EamA-like transporter family; Region: EamA; pfam00892 525284004118 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 525284004119 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 525284004120 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 525284004121 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 525284004122 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 525284004123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284004124 dimer interface [polypeptide binding]; other site 525284004125 conserved gate region; other site 525284004126 putative PBP binding loops; other site 525284004127 ABC-ATPase subunit interface; other site 525284004128 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 525284004129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525284004130 dimer interface [polypeptide binding]; other site 525284004131 conserved gate region; other site 525284004132 putative PBP binding loops; other site 525284004133 ABC-ATPase subunit interface; other site 525284004134 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 525284004135 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 525284004136 Transcriptional regulators [Transcription]; Region: PurR; COG1609 525284004137 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 525284004138 DNA binding site [nucleotide binding] 525284004139 domain linker motif; other site 525284004140 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 525284004141 ligand binding site [chemical binding]; other site 525284004142 dimerization interface [polypeptide binding]; other site 525284004143 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 525284004144 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 525284004145 dimerization interface 3.5A [polypeptide binding]; other site 525284004146 active site 525284004147 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 525284004148 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 525284004149 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 525284004150 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 525284004151 alphaNTD homodimer interface [polypeptide binding]; other site 525284004152 alphaNTD - beta interaction site [polypeptide binding]; other site 525284004153 alphaNTD - beta' interaction site [polypeptide binding]; other site 525284004154 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 525284004155 30S ribosomal protein S11; Validated; Region: PRK05309 525284004156 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 525284004157 30S ribosomal protein S13; Region: bact_S13; TIGR03631 525284004158 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 525284004159 rRNA binding site [nucleotide binding]; other site 525284004160 predicted 30S ribosome binding site; other site 525284004161 adenylate kinase; Reviewed; Region: adk; PRK00279 525284004162 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 525284004163 AMP-binding site [chemical binding]; other site 525284004164 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 525284004165 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 525284004166 SecY translocase; Region: SecY; pfam00344 525284004167 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 525284004168 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 525284004169 23S rRNA binding site [nucleotide binding]; other site 525284004170 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 525284004171 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 525284004172 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 525284004173 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 525284004174 23S rRNA interface [nucleotide binding]; other site 525284004175 5S rRNA interface [nucleotide binding]; other site 525284004176 L27 interface [polypeptide binding]; other site 525284004177 L5 interface [polypeptide binding]; other site 525284004178 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 525284004179 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 525284004180 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 525284004181 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 525284004182 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 525284004183 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 525284004184 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 525284004185 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 525284004186 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 525284004187 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 525284004188 RNA binding site [nucleotide binding]; other site 525284004189 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 525284004190 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 525284004191 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 525284004192 23S rRNA interface [nucleotide binding]; other site 525284004193 putative translocon interaction site; other site 525284004194 signal recognition particle (SRP54) interaction site; other site 525284004195 L23 interface [polypeptide binding]; other site 525284004196 trigger factor interaction site; other site 525284004197 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 525284004198 23S rRNA interface [nucleotide binding]; other site 525284004199 5S rRNA interface [nucleotide binding]; other site 525284004200 putative antibiotic binding site [chemical binding]; other site 525284004201 L25 interface [polypeptide binding]; other site 525284004202 L27 interface [polypeptide binding]; other site 525284004203 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 525284004204 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 525284004205 G-X-X-G motif; other site 525284004206 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 525284004207 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 525284004208 putative translocon binding site; other site 525284004209 protein-rRNA interface [nucleotide binding]; other site 525284004210 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 525284004211 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 525284004212 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 525284004213 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 525284004214 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 525284004215 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 525284004216 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 525284004217 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 525284004218 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 525284004219 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 525284004220 putative catalytic cysteine [active] 525284004221 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 525284004222 putative active site [active] 525284004223 metal binding site [ion binding]; metal-binding site 525284004224 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 525284004225 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 525284004226 23S rRNA interface [nucleotide binding]; other site 525284004227 L3 interface [polypeptide binding]; other site 525284004228 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 525284004229 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 525284004230 Uncharacterized conserved protein [Function unknown]; Region: COG1739 525284004231 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 525284004232 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 525284004233 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 525284004234 putative homodimer interface [polypeptide binding]; other site 525284004235 putative homotetramer interface [polypeptide binding]; other site 525284004236 putative allosteric switch controlling residues; other site 525284004237 putative metal binding site [ion binding]; other site 525284004238 putative homodimer-homodimer interface [polypeptide binding]; other site 525284004239 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 525284004240 EamA-like transporter family; Region: EamA; cl17759 525284004241 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 525284004242 active site 525284004243 DNA polymerase IV; Validated; Region: PRK02406 525284004244 DNA binding site [nucleotide binding] 525284004245 Ferredoxin [Energy production and conversion]; Region: COG1146 525284004246 4Fe-4S binding domain; Region: Fer4; pfam00037 525284004247 amino acid transporter; Region: 2A0306; TIGR00909 525284004248 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 525284004249 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 525284004250 FAD binding domain; Region: FAD_binding_4; pfam01565 525284004251 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 525284004252 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 525284004253 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 525284004254 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 525284004255 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525284004256 homodimer interface [polypeptide binding]; other site 525284004257 catalytic residue [active] 525284004258 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 525284004259 oligomerisation interface [polypeptide binding]; other site 525284004260 mobile loop; other site 525284004261 roof hairpin; other site 525284004262 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 525284004263 This domain family includes a range of different proteins. Such as antifreeze proteins and flagellar FlgA proteins, and CpaB pilus proteins; Region: SAF; smart00858 525284004264 FHA domain; Region: FHA; pfam00498 525284004265 phosphopeptide binding site; other site 525284004266 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 525284004267 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 525284004268 HIGH motif; other site 525284004269 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 525284004270 active site 525284004271 KMSKS motif; other site 525284004272 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 525284004273 catalytic core [active] 525284004274 Predicted membrane protein [Function unknown]; Region: COG2246 525284004275 GtrA-like protein; Region: GtrA; pfam04138 525284004276 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 525284004277 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 525284004278 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 525284004279 cofactor binding site; other site 525284004280 DNA binding site [nucleotide binding] 525284004281 substrate interaction site [chemical binding]; other site 525284004282 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525284004283 non-specific DNA binding site [nucleotide binding]; other site 525284004284 salt bridge; other site 525284004285 sequence-specific DNA binding site [nucleotide binding]; other site 525284004286 BRO family, N-terminal domain; Region: Bro-N; cl10591 525284004287 BRO family, N-terminal domain; Region: Bro-N; cl10591 525284004288 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 525284004289 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 525284004290 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 525284004291 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 525284004292 active site 525284004293 HIGH motif; other site 525284004294 nucleotide binding site [chemical binding]; other site 525284004295 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 525284004296 KMSK motif region; other site 525284004297 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 525284004298 tRNA binding surface [nucleotide binding]; other site 525284004299 anticodon binding site; other site 525284004300 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 525284004301 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 525284004302 active site 525284004303 HIGH motif; other site 525284004304 nucleotide binding site [chemical binding]; other site 525284004305 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 525284004306 active site 525284004307 KMSKS motif; other site 525284004308 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 525284004309 tRNA binding surface [nucleotide binding]; other site 525284004310 anticodon binding site; other site 525284004311 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 525284004312 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 525284004313 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 525284004314 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 525284004315 minor groove reading motif; other site 525284004316 helix-hairpin-helix signature motif; other site 525284004317 substrate binding pocket [chemical binding]; other site 525284004318 active site 525284004319 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 525284004320 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 525284004321 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 525284004322 DNA binding site [nucleotide binding] 525284004323 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 525284004324 dimer interface [polypeptide binding]; other site 525284004325 substrate binding site [chemical binding]; other site 525284004326 metal binding sites [ion binding]; metal-binding site 525284004327 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 525284004328 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 525284004329 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 525284004330 catalytic triad [active] 525284004331 catalytic triad [active] 525284004332 oxyanion hole [active] 525284004333 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 525284004334 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 525284004335 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 525284004336 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 525284004337 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 525284004338 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 525284004339 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 525284004340 putative active site [active] 525284004341 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 525284004342 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 525284004343 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 525284004344 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 525284004345 catalytic residues [active] 525284004346 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 525284004347 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 525284004348 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 525284004349 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 525284004350 Class I ribonucleotide reductase; Region: RNR_I; cd01679 525284004351 active site 525284004352 dimer interface [polypeptide binding]; other site 525284004353 catalytic residues [active] 525284004354 effector binding site; other site 525284004355 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 525284004356 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 525284004357 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 525284004358 dimer interface [polypeptide binding]; other site 525284004359 putative radical transfer pathway; other site 525284004360 diiron center [ion binding]; other site 525284004361 tyrosyl radical; other site 525284004362 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 525284004363 RelB antitoxin; Region: RelB; cl01171 525284004364 Archaeal ATPase; Region: Arch_ATPase; pfam01637 525284004365 AAA ATPase domain; Region: AAA_16; pfam13191 525284004366 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 525284004367 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 525284004368 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 525284004369 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 525284004370 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 525284004371 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 525284004372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525284004373 active site 525284004374 phosphorylation site [posttranslational modification] 525284004375 intermolecular recognition site; other site 525284004376 dimerization interface [polypeptide binding]; other site 525284004377 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 525284004378 DNA binding residues [nucleotide binding] 525284004379 dimerization interface [polypeptide binding]; other site 525284004380 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 525284004381 Histidine kinase; Region: HisKA_3; pfam07730 525284004382 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 525284004383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525284004384 active site 525284004385 phosphorylation site [posttranslational modification] 525284004386 intermolecular recognition site; other site 525284004387 dimerization interface [polypeptide binding]; other site 525284004388 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 525284004389 DNA binding residues [nucleotide binding] 525284004390 dimerization interface [polypeptide binding]; other site 525284004391 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 525284004392 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 525284004393 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 525284004394 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525284004395 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 525284004396 Walker A/P-loop; other site 525284004397 ATP binding site [chemical binding]; other site 525284004398 Q-loop/lid; other site 525284004399 ABC transporter signature motif; other site 525284004400 Walker B; other site 525284004401 D-loop; other site 525284004402 H-loop/switch region; other site 525284004403 FtsX-like permease family; Region: FtsX; pfam02687 525284004404 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 525284004405 FtsX-like permease family; Region: FtsX; pfam02687 525284004406 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 525284004407 Fe2+ transport protein; Region: Iron_transport; pfam10634 525284004408 Iron permease FTR1 family; Region: FTR1; cl00475 525284004409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 525284004410 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 525284004411 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 525284004412 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 525284004413 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 525284004414 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 525284004415 Walker A/P-loop; other site 525284004416 ATP binding site [chemical binding]; other site 525284004417 Q-loop/lid; other site 525284004418 ABC transporter signature motif; other site 525284004419 Walker B; other site 525284004420 D-loop; other site 525284004421 H-loop/switch region; other site 525284004422 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525284004423 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 525284004424 active site 525284004425 phosphorylation site [posttranslational modification] 525284004426 intermolecular recognition site; other site 525284004427 dimerization interface [polypeptide binding]; other site 525284004428 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 525284004429 DNA binding site [nucleotide binding] 525284004430 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525284004431 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525284004432 dimer interface [polypeptide binding]; other site 525284004433 phosphorylation site [posttranslational modification] 525284004434 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525284004435 ATP binding site [chemical binding]; other site 525284004436 Mg2+ binding site [ion binding]; other site 525284004437 G-X-G motif; other site 525284004438 ApbE family; Region: ApbE; pfam02424 525284004439 Fic family protein [Function unknown]; Region: COG3177 525284004440 Fic/DOC family; Region: Fic; pfam02661