-- dump date 20140619_100851 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1009464000001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009464000002 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1009464000003 Walker A motif; other site 1009464000004 ATP binding site [chemical binding]; other site 1009464000005 Walker B motif; other site 1009464000006 arginine finger; other site 1009464000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1009464000008 DnaA box-binding interface [nucleotide binding]; other site 1009464000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1009464000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1009464000011 putative DNA binding surface [nucleotide binding]; other site 1009464000012 dimer interface [polypeptide binding]; other site 1009464000013 beta-clamp/clamp loader binding surface; other site 1009464000014 beta-clamp/translesion DNA polymerase binding surface; other site 1009464000015 Protein of unknown function (DUF721); Region: DUF721; pfam05258 1009464000016 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1009464000017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009464000018 Mg2+ binding site [ion binding]; other site 1009464000019 G-X-G motif; other site 1009464000020 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1009464000021 anchoring element; other site 1009464000022 dimer interface [polypeptide binding]; other site 1009464000023 ATP binding site [chemical binding]; other site 1009464000024 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1009464000025 active site 1009464000026 putative metal-binding site [ion binding]; other site 1009464000027 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1009464000028 DNA gyrase subunit A; Validated; Region: PRK05560 1009464000029 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1009464000030 CAP-like domain; other site 1009464000031 active site 1009464000032 primary dimer interface [polypeptide binding]; other site 1009464000033 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1009464000034 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1009464000035 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1009464000036 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1009464000037 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1009464000038 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1009464000039 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 1009464000040 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1009464000041 active site 1009464000042 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1009464000043 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1009464000044 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1009464000045 phosphopeptide binding site; other site 1009464000046 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1009464000047 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1009464000048 phosphopeptide binding site; other site 1009464000049 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1009464000050 active site 1009464000051 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1009464000052 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1009464000053 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1009464000054 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1009464000055 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1009464000056 active site 1009464000057 ATP binding site [chemical binding]; other site 1009464000058 substrate binding site [chemical binding]; other site 1009464000059 activation loop (A-loop); other site 1009464000060 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1009464000061 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1009464000062 active site 1009464000063 ATP binding site [chemical binding]; other site 1009464000064 substrate binding site [chemical binding]; other site 1009464000065 activation loop (A-loop); other site 1009464000066 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1009464000067 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1009464000068 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1009464000069 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 1009464000070 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 1009464000071 active site 1009464000072 catalytic site [active] 1009464000073 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1009464000074 putative septation inhibitor protein; Reviewed; Region: PRK02251 1009464000075 Rhomboid family; Region: Rhomboid; pfam01694 1009464000076 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1009464000077 homodimer interface [polypeptide binding]; other site 1009464000078 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1009464000079 active site pocket [active] 1009464000080 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1009464000081 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1009464000082 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1009464000083 active site 1009464000084 HIGH motif; other site 1009464000085 dimer interface [polypeptide binding]; other site 1009464000086 KMSKS motif; other site 1009464000087 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1009464000088 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1009464000089 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1009464000090 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1009464000091 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 1009464000092 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1009464000093 active site clefts [active] 1009464000094 zinc binding site [ion binding]; other site 1009464000095 dimer interface [polypeptide binding]; other site 1009464000096 Predicted permease; Region: DUF318; cl17795 1009464000097 TIGR03943 family protein; Region: TIGR03943 1009464000098 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1009464000099 Domain of unknown function DUF21; Region: DUF21; pfam01595 1009464000100 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1009464000101 Transporter associated domain; Region: CorC_HlyC; smart01091 1009464000102 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1009464000103 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1009464000104 dimerization interface [polypeptide binding]; other site 1009464000105 DPS ferroxidase diiron center [ion binding]; other site 1009464000106 ion pore; other site 1009464000107 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1009464000108 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1009464000109 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1009464000110 motif II; other site 1009464000111 ferredoxin-NADP+ reductase; Region: PLN02852 1009464000112 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1009464000113 Peptidase family M48; Region: Peptidase_M48; cl12018 1009464000114 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1009464000115 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1009464000116 Walker A/P-loop; other site 1009464000117 ATP binding site [chemical binding]; other site 1009464000118 Q-loop/lid; other site 1009464000119 ABC transporter signature motif; other site 1009464000120 Walker B; other site 1009464000121 D-loop; other site 1009464000122 H-loop/switch region; other site 1009464000123 Helix-turn-helix domain; Region: HTH_17; pfam12728 1009464000124 Fic family protein [Function unknown]; Region: COG3177 1009464000125 Fic/DOC family; Region: Fic; pfam02661 1009464000126 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1009464000127 AAA domain; Region: AAA_14; pfam13173 1009464000128 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1009464000129 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 1009464000130 nucleophilic elbow; other site 1009464000131 catalytic triad; other site 1009464000132 Runt domain; Region: Runt; pfam00853 1009464000133 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1009464000134 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1009464000135 nucleotide binding site [chemical binding]; other site 1009464000136 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1009464000137 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1009464000138 putative active site cavity [active] 1009464000139 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1009464000140 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1009464000141 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1009464000142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464000143 dimer interface [polypeptide binding]; other site 1009464000144 conserved gate region; other site 1009464000145 putative PBP binding loops; other site 1009464000146 ABC-ATPase subunit interface; other site 1009464000147 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1009464000148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464000149 dimer interface [polypeptide binding]; other site 1009464000150 conserved gate region; other site 1009464000151 putative PBP binding loops; other site 1009464000152 ABC-ATPase subunit interface; other site 1009464000153 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1009464000154 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1009464000155 Walker A/P-loop; other site 1009464000156 ATP binding site [chemical binding]; other site 1009464000157 Q-loop/lid; other site 1009464000158 ABC transporter signature motif; other site 1009464000159 Walker B; other site 1009464000160 D-loop; other site 1009464000161 H-loop/switch region; other site 1009464000162 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1009464000163 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1009464000164 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1009464000165 Walker A/P-loop; other site 1009464000166 ATP binding site [chemical binding]; other site 1009464000167 Q-loop/lid; other site 1009464000168 ABC transporter signature motif; other site 1009464000169 Walker B; other site 1009464000170 D-loop; other site 1009464000171 H-loop/switch region; other site 1009464000172 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1009464000173 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1009464000174 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1009464000175 inhibitor site; inhibition site 1009464000176 active site 1009464000177 dimer interface [polypeptide binding]; other site 1009464000178 catalytic residue [active] 1009464000179 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1009464000180 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1009464000181 active site 1009464000182 trimer interface [polypeptide binding]; other site 1009464000183 allosteric site; other site 1009464000184 active site lid [active] 1009464000185 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1009464000186 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1009464000187 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1009464000188 active site 1009464000189 dimer interface [polypeptide binding]; other site 1009464000190 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1009464000191 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009464000192 DNA-binding site [nucleotide binding]; DNA binding site 1009464000193 FCD domain; Region: FCD; pfam07729 1009464000194 Laminin G domain; Region: Laminin_G_2; pfam02210 1009464000195 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 1009464000196 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 1009464000197 Asp-box motif; other site 1009464000198 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1009464000199 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1009464000200 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1009464000201 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1009464000202 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1009464000203 FMN binding site [chemical binding]; other site 1009464000204 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1009464000205 dimer interface [polypeptide binding]; other site 1009464000206 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1009464000207 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1009464000208 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1009464000209 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1009464000210 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1009464000211 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1009464000212 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1009464000213 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1009464000214 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1009464000215 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1009464000216 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1009464000217 trimer interface [polypeptide binding]; other site 1009464000218 active site 1009464000219 Predicted esterase [General function prediction only]; Region: COG0400 1009464000220 Serine hydrolase (FSH1); Region: FSH1; pfam03959 1009464000221 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1009464000222 nucleoside/Zn binding site; other site 1009464000223 dimer interface [polypeptide binding]; other site 1009464000224 catalytic motif [active] 1009464000225 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1009464000226 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1009464000227 DNA binding site [nucleotide binding] 1009464000228 domain linker motif; other site 1009464000229 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1009464000230 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1009464000231 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1009464000232 Walker A/P-loop; other site 1009464000233 ATP binding site [chemical binding]; other site 1009464000234 Q-loop/lid; other site 1009464000235 ABC transporter signature motif; other site 1009464000236 Walker B; other site 1009464000237 D-loop; other site 1009464000238 H-loop/switch region; other site 1009464000239 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1009464000240 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1009464000241 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1009464000242 TM-ABC transporter signature motif; other site 1009464000243 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1009464000244 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1009464000245 ligand binding site [chemical binding]; other site 1009464000246 dimerization interface [polypeptide binding]; other site 1009464000247 D-ribose pyranase; Provisional; Region: PRK11797 1009464000248 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1009464000249 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1009464000250 substrate binding site [chemical binding]; other site 1009464000251 dimer interface [polypeptide binding]; other site 1009464000252 ATP binding site [chemical binding]; other site 1009464000253 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 1009464000254 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1009464000255 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1009464000256 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1009464000257 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1009464000258 Ca binding site [ion binding]; other site 1009464000259 active site 1009464000260 catalytic site [active] 1009464000261 NAD-dependent deacetylase; Provisional; Region: PRK00481 1009464000262 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1009464000263 NAD+ binding site [chemical binding]; other site 1009464000264 substrate binding site [chemical binding]; other site 1009464000265 Zn binding site [ion binding]; other site 1009464000266 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1009464000267 substrate binding site [chemical binding]; other site 1009464000268 multimerization interface [polypeptide binding]; other site 1009464000269 ATP binding site [chemical binding]; other site 1009464000270 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1009464000271 thiamine phosphate binding site [chemical binding]; other site 1009464000272 active site 1009464000273 pyrophosphate binding site [ion binding]; other site 1009464000274 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1009464000275 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1009464000276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009464000277 active site 1009464000278 phosphorylation site [posttranslational modification] 1009464000279 intermolecular recognition site; other site 1009464000280 dimerization interface [polypeptide binding]; other site 1009464000281 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009464000282 DNA binding residues [nucleotide binding] 1009464000283 dimerization interface [polypeptide binding]; other site 1009464000284 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 1009464000285 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1009464000286 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1009464000287 FtsX-like permease family; Region: FtsX; pfam02687 1009464000288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009464000289 putative substrate translocation pore; other site 1009464000290 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1009464000291 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1009464000292 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1009464000293 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1009464000294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464000295 dimer interface [polypeptide binding]; other site 1009464000296 conserved gate region; other site 1009464000297 putative PBP binding loops; other site 1009464000298 ABC-ATPase subunit interface; other site 1009464000299 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1009464000300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464000301 dimer interface [polypeptide binding]; other site 1009464000302 conserved gate region; other site 1009464000303 putative PBP binding loops; other site 1009464000304 ABC-ATPase subunit interface; other site 1009464000305 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1009464000306 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1009464000307 active site 1009464000308 homodimer interface [polypeptide binding]; other site 1009464000309 catalytic site [active] 1009464000310 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1009464000311 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1009464000312 DNA binding site [nucleotide binding] 1009464000313 domain linker motif; other site 1009464000314 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1009464000315 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 1009464000316 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1009464000317 non-specific DNA binding site [nucleotide binding]; other site 1009464000318 salt bridge; other site 1009464000319 sequence-specific DNA binding site [nucleotide binding]; other site 1009464000320 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1009464000321 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009464000322 homodimer interface [polypeptide binding]; other site 1009464000323 catalytic residue [active] 1009464000324 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1009464000325 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1009464000326 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1009464000327 dimer interface [polypeptide binding]; other site 1009464000328 FMN binding site [chemical binding]; other site 1009464000329 NADPH bind site [chemical binding]; other site 1009464000330 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1009464000331 catalytic core [active] 1009464000332 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1009464000333 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1009464000334 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1009464000335 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1009464000336 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1009464000337 DNA binding site [nucleotide binding] 1009464000338 domain linker motif; other site 1009464000339 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1009464000340 ligand binding site [chemical binding]; other site 1009464000341 dimerization interface [polypeptide binding]; other site 1009464000342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464000343 dimer interface [polypeptide binding]; other site 1009464000344 conserved gate region; other site 1009464000345 putative PBP binding loops; other site 1009464000346 ABC-ATPase subunit interface; other site 1009464000347 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1009464000348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464000349 dimer interface [polypeptide binding]; other site 1009464000350 conserved gate region; other site 1009464000351 putative PBP binding loops; other site 1009464000352 ABC-ATPase subunit interface; other site 1009464000353 Protein of unknown function, DUF624; Region: DUF624; cl02369 1009464000354 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1009464000355 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1009464000356 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1009464000357 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1009464000358 MULE transposase domain; Region: MULE; pfam10551 1009464000359 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1009464000360 non-specific DNA binding site [nucleotide binding]; other site 1009464000361 salt bridge; other site 1009464000362 sequence-specific DNA binding site [nucleotide binding]; other site 1009464000363 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 1009464000364 H+ Antiporter protein; Region: 2A0121; TIGR00900 1009464000365 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 1009464000366 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1009464000367 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1009464000368 active site 1009464000369 DNA binding site [nucleotide binding] 1009464000370 Int/Topo IB signature motif; other site 1009464000371 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1009464000372 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1009464000373 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1009464000374 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1009464000375 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1009464000376 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 1009464000377 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1009464000378 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1009464000379 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1009464000380 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1009464000381 beta subunit interaction interface [polypeptide binding]; other site 1009464000382 Walker A motif; other site 1009464000383 ATP binding site [chemical binding]; other site 1009464000384 Walker B motif; other site 1009464000385 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1009464000386 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1009464000387 core domain interface [polypeptide binding]; other site 1009464000388 delta subunit interface [polypeptide binding]; other site 1009464000389 epsilon subunit interface [polypeptide binding]; other site 1009464000390 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1009464000391 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1009464000392 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1009464000393 alpha subunit interaction interface [polypeptide binding]; other site 1009464000394 Walker A motif; other site 1009464000395 ATP binding site [chemical binding]; other site 1009464000396 Walker B motif; other site 1009464000397 inhibitor binding site; inhibition site 1009464000398 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1009464000399 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1009464000400 gamma subunit interface [polypeptide binding]; other site 1009464000401 LBP interface [polypeptide binding]; other site 1009464000402 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1009464000403 AAA domain; Region: AAA_14; pfam13173 1009464000404 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1009464000405 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1009464000406 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1009464000407 non-specific DNA binding site [nucleotide binding]; other site 1009464000408 salt bridge; other site 1009464000409 sequence-specific DNA binding site [nucleotide binding]; other site 1009464000410 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1009464000411 Fic family protein [Function unknown]; Region: COG3177 1009464000412 Fic/DOC family; Region: Fic; pfam02661 1009464000413 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1009464000414 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1009464000415 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1009464000416 substrate binding site [chemical binding]; other site 1009464000417 dimer interface [polypeptide binding]; other site 1009464000418 ATP binding site [chemical binding]; other site 1009464000419 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 1009464000420 active site 1009464000421 catalytic residues [active] 1009464000422 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1009464000423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009464000424 putative substrate translocation pore; other site 1009464000425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009464000426 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1009464000427 intersubunit interface [polypeptide binding]; other site 1009464000428 active site 1009464000429 catalytic residue [active] 1009464000430 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1009464000431 MarR family; Region: MarR_2; pfam12802 1009464000432 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1009464000433 ApbE family; Region: ApbE; pfam02424 1009464000434 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1009464000435 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1009464000436 dimer interface [polypeptide binding]; other site 1009464000437 phosphorylation site [posttranslational modification] 1009464000438 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009464000439 ATP binding site [chemical binding]; other site 1009464000440 Mg2+ binding site [ion binding]; other site 1009464000441 G-X-G motif; other site 1009464000442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009464000443 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1009464000444 active site 1009464000445 phosphorylation site [posttranslational modification] 1009464000446 intermolecular recognition site; other site 1009464000447 dimerization interface [polypeptide binding]; other site 1009464000448 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1009464000449 DNA binding site [nucleotide binding] 1009464000450 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1009464000451 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1009464000452 Walker A/P-loop; other site 1009464000453 ATP binding site [chemical binding]; other site 1009464000454 Q-loop/lid; other site 1009464000455 ABC transporter signature motif; other site 1009464000456 Walker B; other site 1009464000457 D-loop; other site 1009464000458 H-loop/switch region; other site 1009464000459 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1009464000460 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 1009464000461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 1009464000462 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1009464000463 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 1009464000464 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1009464000465 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1009464000466 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1009464000467 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1009464000468 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1009464000469 Abi-like protein; Region: Abi_2; pfam07751 1009464000470 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1009464000471 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1009464000472 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1009464000473 ATP binding site [chemical binding]; other site 1009464000474 putative Mg++ binding site [ion binding]; other site 1009464000475 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 1009464000476 Fe2+ transport protein; Region: Iron_transport; pfam10634 1009464000477 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 1009464000478 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1009464000479 FtsX-like permease family; Region: FtsX; pfam02687 1009464000480 FtsX-like permease family; Region: FtsX; pfam02687 1009464000481 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1009464000482 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1009464000483 Walker A/P-loop; other site 1009464000484 ATP binding site [chemical binding]; other site 1009464000485 Q-loop/lid; other site 1009464000486 ABC transporter signature motif; other site 1009464000487 Walker B; other site 1009464000488 D-loop; other site 1009464000489 H-loop/switch region; other site 1009464000490 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 1009464000491 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1009464000492 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 1009464000493 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1009464000494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009464000495 active site 1009464000496 phosphorylation site [posttranslational modification] 1009464000497 intermolecular recognition site; other site 1009464000498 dimerization interface [polypeptide binding]; other site 1009464000499 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009464000500 DNA binding residues [nucleotide binding] 1009464000501 dimerization interface [polypeptide binding]; other site 1009464000502 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1009464000503 Histidine kinase; Region: HisKA_3; pfam07730 1009464000504 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1009464000505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009464000506 active site 1009464000507 phosphorylation site [posttranslational modification] 1009464000508 intermolecular recognition site; other site 1009464000509 dimerization interface [polypeptide binding]; other site 1009464000510 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009464000511 DNA binding residues [nucleotide binding] 1009464000512 dimerization interface [polypeptide binding]; other site 1009464000513 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1009464000514 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 1009464000515 Archaeal ATPase; Region: Arch_ATPase; pfam01637 1009464000516 AAA ATPase domain; Region: AAA_16; pfam13191 1009464000517 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1009464000518 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 1009464000519 RelB antitoxin; Region: RelB; cl01171 1009464000520 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 1009464000521 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1009464000522 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1009464000523 dimer interface [polypeptide binding]; other site 1009464000524 putative radical transfer pathway; other site 1009464000525 diiron center [ion binding]; other site 1009464000526 tyrosyl radical; other site 1009464000527 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1009464000528 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1009464000529 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 1009464000530 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1009464000531 active site 1009464000532 dimer interface [polypeptide binding]; other site 1009464000533 catalytic residues [active] 1009464000534 effector binding site; other site 1009464000535 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1009464000536 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1009464000537 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1009464000538 catalytic residues [active] 1009464000539 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1009464000540 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1009464000541 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1009464000542 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1009464000543 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1009464000544 putative active site [active] 1009464000545 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1009464000546 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 1009464000547 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1009464000548 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1009464000549 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1009464000550 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1009464000551 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1009464000552 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1009464000553 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1009464000554 catalytic triad [active] 1009464000555 catalytic triad [active] 1009464000556 oxyanion hole [active] 1009464000557 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1009464000558 dimer interface [polypeptide binding]; other site 1009464000559 substrate binding site [chemical binding]; other site 1009464000560 metal binding sites [ion binding]; metal-binding site 1009464000561 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1009464000562 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1009464000563 DNA binding site [nucleotide binding] 1009464000564 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1009464000565 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1009464000566 minor groove reading motif; other site 1009464000567 helix-hairpin-helix signature motif; other site 1009464000568 substrate binding pocket [chemical binding]; other site 1009464000569 active site 1009464000570 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1009464000571 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1009464000572 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 1009464000573 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 1009464000574 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1009464000575 active site 1009464000576 HIGH motif; other site 1009464000577 nucleotide binding site [chemical binding]; other site 1009464000578 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1009464000579 active site 1009464000580 KMSKS motif; other site 1009464000581 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1009464000582 tRNA binding surface [nucleotide binding]; other site 1009464000583 anticodon binding site; other site 1009464000584 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1009464000585 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1009464000586 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1009464000587 active site 1009464000588 HIGH motif; other site 1009464000589 nucleotide binding site [chemical binding]; other site 1009464000590 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1009464000591 KMSK motif region; other site 1009464000592 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1009464000593 tRNA binding surface [nucleotide binding]; other site 1009464000594 anticodon binding site; other site 1009464000595 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1009464000596 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 1009464000597 Predicted membrane protein [Function unknown]; Region: COG2246 1009464000598 GtrA-like protein; Region: GtrA; pfam04138 1009464000599 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1009464000600 catalytic core [active] 1009464000601 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1009464000602 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1009464000603 HIGH motif; other site 1009464000604 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1009464000605 active site 1009464000606 KMSKS motif; other site 1009464000607 Cna protein B-type domain; Region: Cna_B; pfam05738 1009464000608 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1009464000609 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1009464000610 active site 1009464000611 catalytic site [active] 1009464000612 FHA domain; Region: FHA; pfam00498 1009464000613 phosphopeptide binding site; other site 1009464000614 This domain family includes a range of different proteins. Such as antifreeze proteins and flagellar FlgA proteins, and CpaB pilus proteins; Region: SAF; smart00858 1009464000615 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1009464000616 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1009464000617 oligomerisation interface [polypeptide binding]; other site 1009464000618 mobile loop; other site 1009464000619 roof hairpin; other site 1009464000620 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1009464000621 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1009464000622 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009464000623 homodimer interface [polypeptide binding]; other site 1009464000624 catalytic residue [active] 1009464000625 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1009464000626 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1009464000627 FAD binding domain; Region: FAD_binding_4; pfam01565 1009464000628 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1009464000629 amino acid transporter; Region: 2A0306; TIGR00909 1009464000630 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1009464000631 Ferredoxin [Energy production and conversion]; Region: COG1146 1009464000632 4Fe-4S binding domain; Region: Fer4; pfam00037 1009464000633 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1009464000634 active site 1009464000635 DNA polymerase IV; Validated; Region: PRK02406 1009464000636 DNA binding site [nucleotide binding] 1009464000637 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1009464000638 EamA-like transporter family; Region: EamA; cl17759 1009464000639 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1009464000640 putative homodimer interface [polypeptide binding]; other site 1009464000641 putative homotetramer interface [polypeptide binding]; other site 1009464000642 putative allosteric switch controlling residues; other site 1009464000643 putative metal binding site [ion binding]; other site 1009464000644 putative homodimer-homodimer interface [polypeptide binding]; other site 1009464000645 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1009464000646 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1009464000647 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1009464000648 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1009464000649 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1009464000650 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1009464000651 23S rRNA interface [nucleotide binding]; other site 1009464000652 L3 interface [polypeptide binding]; other site 1009464000653 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1009464000654 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1009464000655 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1009464000656 putative catalytic cysteine [active] 1009464000657 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1009464000658 putative active site [active] 1009464000659 metal binding site [ion binding]; metal-binding site 1009464000660 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1009464000661 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1009464000662 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1009464000663 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1009464000664 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1009464000665 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1009464000666 putative translocon binding site; other site 1009464000667 protein-rRNA interface [nucleotide binding]; other site 1009464000668 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1009464000669 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1009464000670 G-X-X-G motif; other site 1009464000671 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1009464000672 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1009464000673 23S rRNA interface [nucleotide binding]; other site 1009464000674 5S rRNA interface [nucleotide binding]; other site 1009464000675 putative antibiotic binding site [chemical binding]; other site 1009464000676 L25 interface [polypeptide binding]; other site 1009464000677 L27 interface [polypeptide binding]; other site 1009464000678 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1009464000679 23S rRNA interface [nucleotide binding]; other site 1009464000680 putative translocon interaction site; other site 1009464000681 signal recognition particle (SRP54) interaction site; other site 1009464000682 L23 interface [polypeptide binding]; other site 1009464000683 trigger factor interaction site; other site 1009464000684 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1009464000685 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1009464000686 RNA binding site [nucleotide binding]; other site 1009464000687 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1009464000688 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1009464000689 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1009464000690 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1009464000691 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1009464000692 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1009464000693 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1009464000694 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1009464000695 23S rRNA interface [nucleotide binding]; other site 1009464000696 5S rRNA interface [nucleotide binding]; other site 1009464000697 L27 interface [polypeptide binding]; other site 1009464000698 L5 interface [polypeptide binding]; other site 1009464000699 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1009464000700 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1009464000701 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1009464000702 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1009464000703 23S rRNA binding site [nucleotide binding]; other site 1009464000704 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1009464000705 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1009464000706 SecY translocase; Region: SecY; pfam00344 1009464000707 adenylate kinase; Reviewed; Region: adk; PRK00279 1009464000708 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1009464000709 AMP-binding site [chemical binding]; other site 1009464000710 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1009464000711 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1009464000712 rRNA binding site [nucleotide binding]; other site 1009464000713 predicted 30S ribosome binding site; other site 1009464000714 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1009464000715 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1009464000716 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1009464000717 30S ribosomal protein S11; Validated; Region: PRK05309 1009464000718 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1009464000719 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1009464000720 alphaNTD homodimer interface [polypeptide binding]; other site 1009464000721 alphaNTD - beta interaction site [polypeptide binding]; other site 1009464000722 alphaNTD - beta' interaction site [polypeptide binding]; other site 1009464000723 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1009464000724 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1009464000725 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 1009464000726 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1009464000727 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1009464000728 dimerization interface 3.5A [polypeptide binding]; other site 1009464000729 active site 1009464000730 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1009464000731 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1009464000732 DNA binding site [nucleotide binding] 1009464000733 domain linker motif; other site 1009464000734 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1009464000735 ligand binding site [chemical binding]; other site 1009464000736 dimerization interface [polypeptide binding]; other site 1009464000737 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1009464000738 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1009464000739 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1009464000740 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464000741 dimer interface [polypeptide binding]; other site 1009464000742 conserved gate region; other site 1009464000743 putative PBP binding loops; other site 1009464000744 ABC-ATPase subunit interface; other site 1009464000745 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1009464000746 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464000747 dimer interface [polypeptide binding]; other site 1009464000748 conserved gate region; other site 1009464000749 putative PBP binding loops; other site 1009464000750 ABC-ATPase subunit interface; other site 1009464000751 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1009464000752 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1009464000753 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1009464000754 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1009464000755 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1009464000756 EamA-like transporter family; Region: EamA; pfam00892 1009464000757 EamA-like transporter family; Region: EamA; pfam00892 1009464000758 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1009464000759 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1009464000760 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 1009464000761 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1009464000762 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1009464000763 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1009464000764 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 1009464000765 Domain of unknown function (DUF386); Region: DUF386; cl01047 1009464000766 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1009464000767 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1009464000768 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1009464000769 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1009464000770 D-xylulose kinase; Region: XylB; TIGR01312 1009464000771 nucleotide binding site [chemical binding]; other site 1009464000772 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1009464000773 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1009464000774 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1009464000775 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1009464000776 Walker A/P-loop; other site 1009464000777 ATP binding site [chemical binding]; other site 1009464000778 Q-loop/lid; other site 1009464000779 ABC transporter signature motif; other site 1009464000780 Walker B; other site 1009464000781 D-loop; other site 1009464000782 H-loop/switch region; other site 1009464000783 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1009464000784 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1009464000785 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1009464000786 TM-ABC transporter signature motif; other site 1009464000787 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1009464000788 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1009464000789 TM-ABC transporter signature motif; other site 1009464000790 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1009464000791 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1009464000792 tetramer interface [polypeptide binding]; other site 1009464000793 active site 1009464000794 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1009464000795 MULE transposase domain; Region: MULE; pfam10551 1009464000796 RES domain; Region: RES; smart00953 1009464000797 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1009464000798 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1009464000799 DNA binding site [nucleotide binding] 1009464000800 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1009464000801 ligand binding site [chemical binding]; other site 1009464000802 dimerization interface [polypeptide binding]; other site 1009464000803 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1009464000804 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1009464000805 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1009464000806 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1009464000807 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1009464000808 active site 1009464000809 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1009464000810 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1009464000811 DNA binding site [nucleotide binding] 1009464000812 domain linker motif; other site 1009464000813 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1009464000814 dimerization interface [polypeptide binding]; other site 1009464000815 ligand binding site [chemical binding]; other site 1009464000816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464000817 dimer interface [polypeptide binding]; other site 1009464000818 conserved gate region; other site 1009464000819 putative PBP binding loops; other site 1009464000820 ABC-ATPase subunit interface; other site 1009464000821 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1009464000822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464000823 dimer interface [polypeptide binding]; other site 1009464000824 conserved gate region; other site 1009464000825 putative PBP binding loops; other site 1009464000826 ABC-ATPase subunit interface; other site 1009464000827 Glycosyl hydrolase family 43; Region: GH43_bXyl_2; cd08991 1009464000828 active site 1009464000829 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1009464000830 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1009464000831 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1009464000832 synthetase active site [active] 1009464000833 NTP binding site [chemical binding]; other site 1009464000834 metal binding site [ion binding]; metal-binding site 1009464000835 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 1009464000836 BioY family; Region: BioY; pfam02632 1009464000837 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1009464000838 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1009464000839 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1009464000840 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1009464000841 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1009464000842 carboxyltransferase (CT) interaction site; other site 1009464000843 biotinylation site [posttranslational modification]; other site 1009464000844 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1009464000845 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1009464000846 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1009464000847 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1009464000848 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1009464000849 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1009464000850 phosphate binding site [ion binding]; other site 1009464000851 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1009464000852 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 1009464000853 putative active site [active] 1009464000854 putative catalytic site [active] 1009464000855 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1009464000856 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1009464000857 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1009464000858 putative NAD(P) binding site [chemical binding]; other site 1009464000859 active site 1009464000860 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1009464000861 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1009464000862 active site 1009464000863 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 1009464000864 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1009464000865 active site 1009464000866 Ca binding site [ion binding]; other site 1009464000867 catalytic site [active] 1009464000868 Aamy_C domain; Region: Aamy_C; smart00632 1009464000869 Carbohydrate binding domain; Region: CBM_25; smart01066 1009464000870 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 1009464000871 carbohydrate binding site [chemical binding]; other site 1009464000872 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 1009464000873 carbohydrate binding site [chemical binding]; other site 1009464000874 pullulanase, type I; Region: pulA_typeI; TIGR02104 1009464000875 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1009464000876 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1009464000877 Ca binding site [ion binding]; other site 1009464000878 active site 1009464000879 catalytic site [active] 1009464000880 Rib/alpha-like repeat; Region: Rib; cl07159 1009464000881 Rib/alpha-like repeat; Region: Rib; cl07159 1009464000882 Rib/alpha-like repeat; Region: Rib; pfam08428 1009464000883 Rib/alpha-like repeat; Region: Rib; cl07159 1009464000884 Rib/alpha-like repeat; Region: Rib; cl07159 1009464000885 Rib/alpha-like repeat; Region: Rib; cl07159 1009464000886 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1009464000887 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1009464000888 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 1009464000889 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1009464000890 active site 1009464000891 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1009464000892 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1009464000893 active site 1009464000894 dimer interface [polypeptide binding]; other site 1009464000895 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1009464000896 dimer interface [polypeptide binding]; other site 1009464000897 active site 1009464000898 ykoK leader 1009464000899 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 1009464000900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464000901 dimer interface [polypeptide binding]; other site 1009464000902 conserved gate region; other site 1009464000903 putative PBP binding loops; other site 1009464000904 ABC-ATPase subunit interface; other site 1009464000905 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464000906 dimer interface [polypeptide binding]; other site 1009464000907 conserved gate region; other site 1009464000908 putative PBP binding loops; other site 1009464000909 ABC-ATPase subunit interface; other site 1009464000910 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1009464000911 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1009464000912 Walker A/P-loop; other site 1009464000913 ATP binding site [chemical binding]; other site 1009464000914 Q-loop/lid; other site 1009464000915 ABC transporter signature motif; other site 1009464000916 Walker B; other site 1009464000917 D-loop; other site 1009464000918 H-loop/switch region; other site 1009464000919 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 1009464000920 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1009464000921 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1009464000922 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1009464000923 Catalytic site [active] 1009464000924 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1009464000925 RNA/DNA hybrid binding site [nucleotide binding]; other site 1009464000926 active site 1009464000927 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009464000928 Q-loop/lid; other site 1009464000929 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1009464000930 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1009464000931 ambiguous bases; G vs T in a repeat region 1009464000932 EamA-like transporter family; Region: EamA; pfam00892 1009464000933 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1009464000934 EamA-like transporter family; Region: EamA; pfam00892 1009464000935 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1009464000936 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1009464000937 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1009464000938 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1009464000939 RPB1 interaction site [polypeptide binding]; other site 1009464000940 RPB10 interaction site [polypeptide binding]; other site 1009464000941 RPB11 interaction site [polypeptide binding]; other site 1009464000942 RPB3 interaction site [polypeptide binding]; other site 1009464000943 RPB12 interaction site [polypeptide binding]; other site 1009464000944 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1009464000945 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1009464000946 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1009464000947 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1009464000948 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1009464000949 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1009464000950 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1009464000951 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1009464000952 DNA binding site [nucleotide binding] 1009464000953 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1009464000954 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1009464000955 AAA domain; Region: AAA_14; pfam13173 1009464000956 Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945 1009464000957 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1009464000958 active site 1009464000959 catalytic site [active] 1009464000960 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 1009464000961 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 1009464000962 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1009464000963 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1009464000964 Part of AAA domain; Region: AAA_19; pfam13245 1009464000965 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 1009464000966 Family description; Region: UvrD_C_2; pfam13538 1009464000967 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1009464000968 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1009464000969 Coenzyme A binding pocket [chemical binding]; other site 1009464000970 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1009464000971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1009464000972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009464000973 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1009464000974 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1009464000975 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1009464000976 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1009464000977 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1009464000978 Zn binding site [ion binding]; other site 1009464000979 proline aminopeptidase P II; Provisional; Region: PRK10879 1009464000980 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 1009464000981 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1009464000982 active site 1009464000983 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1009464000984 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1009464000985 putative substrate binding site [chemical binding]; other site 1009464000986 putative ATP binding site [chemical binding]; other site 1009464000987 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 1009464000988 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1009464000989 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1009464000990 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1009464000991 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1009464000992 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1009464000993 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1009464000994 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1009464000995 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1009464000996 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1009464000997 active site 1009464000998 catalytic site [active] 1009464000999 substrate binding site [chemical binding]; other site 1009464001000 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1009464001001 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1009464001002 dimer interface [polypeptide binding]; other site 1009464001003 active site 1009464001004 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1009464001005 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1009464001006 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1009464001007 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1009464001008 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1009464001009 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1009464001010 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1009464001011 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1009464001012 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1009464001013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464001014 dimer interface [polypeptide binding]; other site 1009464001015 conserved gate region; other site 1009464001016 putative PBP binding loops; other site 1009464001017 ABC-ATPase subunit interface; other site 1009464001018 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1009464001019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464001020 dimer interface [polypeptide binding]; other site 1009464001021 conserved gate region; other site 1009464001022 putative PBP binding loops; other site 1009464001023 ABC-ATPase subunit interface; other site 1009464001024 MarR family; Region: MarR_2; pfam12802 1009464001025 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1009464001026 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1009464001027 nucleotide binding site [chemical binding]; other site 1009464001028 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1009464001029 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009464001030 NAD(P) binding site [chemical binding]; other site 1009464001031 active site 1009464001032 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1009464001033 non-specific DNA binding site [nucleotide binding]; other site 1009464001034 salt bridge; other site 1009464001035 sequence-specific DNA binding site [nucleotide binding]; other site 1009464001036 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1009464001037 Zeta toxin; Region: Zeta_toxin; pfam06414 1009464001038 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1009464001039 active site 1009464001040 catalytic residues [active] 1009464001041 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1009464001042 putative deacylase active site [active] 1009464001043 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1009464001044 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1009464001045 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1009464001046 Thiamine pyrophosphokinase; Region: TPK; cd07995 1009464001047 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1009464001048 active site 1009464001049 dimerization interface [polypeptide binding]; other site 1009464001050 thiamine binding site [chemical binding]; other site 1009464001051 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1009464001052 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1009464001053 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1009464001054 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1009464001055 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1009464001056 23S rRNA binding site [nucleotide binding]; other site 1009464001057 L21 binding site [polypeptide binding]; other site 1009464001058 L13 binding site [polypeptide binding]; other site 1009464001059 hypothetical protein; Validated; Region: PRK00194 1009464001060 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 1009464001061 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1009464001062 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1009464001063 substrate binding site [chemical binding]; other site 1009464001064 dimer interface [polypeptide binding]; other site 1009464001065 ATP binding site [chemical binding]; other site 1009464001066 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1009464001067 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1009464001068 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1009464001069 active site 1009464001070 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1009464001071 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1009464001072 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1009464001073 dimer interface [polypeptide binding]; other site 1009464001074 ssDNA binding site [nucleotide binding]; other site 1009464001075 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1009464001076 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1009464001077 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1009464001078 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1009464001079 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1009464001080 mevalonate kinase; Region: mevalon_kin; TIGR00549 1009464001081 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1009464001082 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 1009464001083 diphosphomevalonate decarboxylase; Region: PLN02407 1009464001084 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 1009464001085 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1009464001086 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1009464001087 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1009464001088 homotetramer interface [polypeptide binding]; other site 1009464001089 FMN binding site [chemical binding]; other site 1009464001090 homodimer contacts [polypeptide binding]; other site 1009464001091 putative active site [active] 1009464001092 putative substrate binding site [chemical binding]; other site 1009464001093 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1009464001094 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1009464001095 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1009464001096 generic binding surface I; other site 1009464001097 generic binding surface II; other site 1009464001098 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1009464001099 ATP binding site [chemical binding]; other site 1009464001100 putative Mg++ binding site [ion binding]; other site 1009464001101 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1009464001102 nucleotide binding region [chemical binding]; other site 1009464001103 ATP-binding site [chemical binding]; other site 1009464001104 putative kinase; Provisional; Region: PRK09954 1009464001105 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1009464001106 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 1009464001107 substrate binding site [chemical binding]; other site 1009464001108 ATP binding site [chemical binding]; other site 1009464001109 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1009464001110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009464001111 putative substrate translocation pore; other site 1009464001112 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1009464001113 active site 1009464001114 tetramer interface [polypeptide binding]; other site 1009464001115 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1009464001116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009464001117 S-adenosylmethionine binding site [chemical binding]; other site 1009464001118 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1009464001119 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1009464001120 RimM N-terminal domain; Region: RimM; pfam01782 1009464001121 hypothetical protein; Provisional; Region: PRK02821 1009464001122 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1009464001123 G-X-X-G motif; other site 1009464001124 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1009464001125 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1009464001126 putative catalytic site [active] 1009464001127 putative metal binding site [ion binding]; other site 1009464001128 putative phosphate binding site [ion binding]; other site 1009464001129 signal recognition particle protein; Provisional; Region: PRK10867 1009464001130 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1009464001131 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1009464001132 P loop; other site 1009464001133 GTP binding site [chemical binding]; other site 1009464001134 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1009464001135 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1009464001136 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1009464001137 active site 1009464001138 HIGH motif; other site 1009464001139 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1009464001140 KMSKS motif; other site 1009464001141 tRNA binding surface [nucleotide binding]; other site 1009464001142 anticodon binding site; other site 1009464001143 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 1009464001144 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1009464001145 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1009464001146 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1009464001147 active site 1009464001148 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1009464001149 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1009464001150 active site 1009464001151 (T/H)XGH motif; other site 1009464001152 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1009464001153 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1009464001154 ribonuclease III; Reviewed; Region: rnc; PRK00102 1009464001155 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1009464001156 dimerization interface [polypeptide binding]; other site 1009464001157 active site 1009464001158 metal binding site [ion binding]; metal-binding site 1009464001159 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1009464001160 dsRNA binding site [nucleotide binding]; other site 1009464001161 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1009464001162 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1009464001163 active site 1009464001164 DNA binding site [nucleotide binding] 1009464001165 Int/Topo IB signature motif; other site 1009464001166 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 1009464001167 RelB antitoxin; Region: RelB; cl01171 1009464001168 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1009464001169 FeS assembly protein SufB; Region: sufB; TIGR01980 1009464001170 FeS assembly protein SufD; Region: sufD; TIGR01981 1009464001171 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1009464001172 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1009464001173 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1009464001174 Walker A/P-loop; other site 1009464001175 ATP binding site [chemical binding]; other site 1009464001176 Q-loop/lid; other site 1009464001177 ABC transporter signature motif; other site 1009464001178 Walker B; other site 1009464001179 D-loop; other site 1009464001180 H-loop/switch region; other site 1009464001181 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1009464001182 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 1009464001183 G1 box; other site 1009464001184 putative GEF interaction site [polypeptide binding]; other site 1009464001185 GTP/Mg2+ binding site [chemical binding]; other site 1009464001186 Switch I region; other site 1009464001187 G2 box; other site 1009464001188 G3 box; other site 1009464001189 Switch II region; other site 1009464001190 G4 box; other site 1009464001191 G5 box; other site 1009464001192 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1009464001193 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1009464001194 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1009464001195 Prephenate dehydratase; Region: PDT; pfam00800 1009464001196 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1009464001197 putative L-Phe binding site [chemical binding]; other site 1009464001198 Prephenate dehydrogenase; Region: PDH; pfam02153 1009464001199 prephenate dehydrogenase; Validated; Region: PRK08507 1009464001200 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1009464001201 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1009464001202 active site 1009464001203 DNA binding site [nucleotide binding] 1009464001204 Int/Topo IB signature motif; other site 1009464001205 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1009464001206 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1009464001207 P-loop; other site 1009464001208 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1009464001209 Magnesium ion binding site [ion binding]; other site 1009464001210 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1009464001211 Magnesium ion binding site [ion binding]; other site 1009464001212 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1009464001213 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1009464001214 active site 1009464001215 catalytic site [active] 1009464001216 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1009464001217 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1009464001218 synthetase active site [active] 1009464001219 NTP binding site [chemical binding]; other site 1009464001220 metal binding site [ion binding]; metal-binding site 1009464001221 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1009464001222 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1009464001223 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1009464001224 MULE transposase domain; Region: MULE; pfam10551 1009464001225 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1009464001226 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1009464001227 dimer interface [polypeptide binding]; other site 1009464001228 active site 1009464001229 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 1009464001230 homodimer interface [polypeptide binding]; other site 1009464001231 helix swapped region; other site 1009464001232 substrate binding pocket [chemical binding]; other site 1009464001233 catalytic residues [active] 1009464001234 NADH/NADPH cofactor binding site [chemical binding]; other site 1009464001235 putative acyltransferase; Provisional; Region: PRK05790 1009464001236 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1009464001237 dimer interface [polypeptide binding]; other site 1009464001238 active site 1009464001239 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1009464001240 active site 1009464001241 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1009464001242 Part of AAA domain; Region: AAA_19; pfam13245 1009464001243 Family description; Region: UvrD_C_2; pfam13538 1009464001244 Domain of unknown function (DUF4418); Region: DUF4418; pfam14387 1009464001245 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1009464001246 FtsX-like permease family; Region: FtsX; pfam02687 1009464001247 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1009464001248 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1009464001249 Walker A/P-loop; other site 1009464001250 ATP binding site [chemical binding]; other site 1009464001251 Q-loop/lid; other site 1009464001252 ABC transporter signature motif; other site 1009464001253 Walker B; other site 1009464001254 D-loop; other site 1009464001255 H-loop/switch region; other site 1009464001256 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1009464001257 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1009464001258 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1009464001259 RNA binding surface [nucleotide binding]; other site 1009464001260 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1009464001261 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1009464001262 dimer interface [polypeptide binding]; other site 1009464001263 active site 1009464001264 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1009464001265 catalytic core [active] 1009464001266 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 1009464001267 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 1009464001268 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1009464001269 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1009464001270 motif 1; other site 1009464001271 active site 1009464001272 motif 2; other site 1009464001273 motif 3; other site 1009464001274 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1009464001275 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1009464001276 YceG-like family; Region: YceG; pfam02618 1009464001277 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 1009464001278 dimerization interface [polypeptide binding]; other site 1009464001279 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1009464001280 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1009464001281 Tetramer interface [polypeptide binding]; other site 1009464001282 active site 1009464001283 FMN-binding site [chemical binding]; other site 1009464001284 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 1009464001285 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1009464001286 ADP binding site [chemical binding]; other site 1009464001287 magnesium binding site [ion binding]; other site 1009464001288 putative shikimate binding site; other site 1009464001289 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1009464001290 active site 1009464001291 dimer interface [polypeptide binding]; other site 1009464001292 metal binding site [ion binding]; metal-binding site 1009464001293 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1009464001294 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1009464001295 trimer interface [polypeptide binding]; other site 1009464001296 active site 1009464001297 dimer interface [polypeptide binding]; other site 1009464001298 CTP synthetase; Validated; Region: pyrG; PRK05380 1009464001299 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1009464001300 Catalytic site [active] 1009464001301 active site 1009464001302 UTP binding site [chemical binding]; other site 1009464001303 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1009464001304 active site 1009464001305 putative oxyanion hole; other site 1009464001306 catalytic triad [active] 1009464001307 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1009464001308 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1009464001309 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1009464001310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464001311 dimer interface [polypeptide binding]; other site 1009464001312 conserved gate region; other site 1009464001313 putative PBP binding loops; other site 1009464001314 ABC-ATPase subunit interface; other site 1009464001315 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1009464001316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464001317 dimer interface [polypeptide binding]; other site 1009464001318 conserved gate region; other site 1009464001319 putative PBP binding loops; other site 1009464001320 ABC-ATPase subunit interface; other site 1009464001321 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1009464001322 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1009464001323 Walker A/P-loop; other site 1009464001324 ATP binding site [chemical binding]; other site 1009464001325 Q-loop/lid; other site 1009464001326 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1009464001327 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1009464001328 ABC transporter signature motif; other site 1009464001329 Walker B; other site 1009464001330 D-loop; other site 1009464001331 H-loop/switch region; other site 1009464001332 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1009464001333 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1009464001334 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1009464001335 Walker A/P-loop; other site 1009464001336 ATP binding site [chemical binding]; other site 1009464001337 Q-loop/lid; other site 1009464001338 ABC transporter signature motif; other site 1009464001339 Walker B; other site 1009464001340 D-loop; other site 1009464001341 H-loop/switch region; other site 1009464001342 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1009464001343 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1009464001344 putative active site [active] 1009464001345 putative catalytic site [active] 1009464001346 putative DNA binding site [nucleotide binding]; other site 1009464001347 putative phosphate binding site [ion binding]; other site 1009464001348 metal binding site A [ion binding]; metal-binding site 1009464001349 putative AP binding site [nucleotide binding]; other site 1009464001350 putative metal binding site B [ion binding]; other site 1009464001351 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1009464001352 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1009464001353 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1009464001354 TRAM domain; Region: TRAM; pfam01938 1009464001355 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1009464001356 putative active site [active] 1009464001357 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1009464001358 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1009464001359 Walker A/P-loop; other site 1009464001360 ATP binding site [chemical binding]; other site 1009464001361 Q-loop/lid; other site 1009464001362 ABC transporter signature motif; other site 1009464001363 Walker B; other site 1009464001364 D-loop; other site 1009464001365 H-loop/switch region; other site 1009464001366 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009464001367 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1009464001368 Walker A/P-loop; other site 1009464001369 ATP binding site [chemical binding]; other site 1009464001370 Q-loop/lid; other site 1009464001371 ABC transporter signature motif; other site 1009464001372 Walker B; other site 1009464001373 D-loop; other site 1009464001374 H-loop/switch region; other site 1009464001375 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1009464001376 catalytic residues [active] 1009464001377 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1009464001378 Integrase core domain; Region: rve_3; cl15866 1009464001379 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 1009464001380 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1009464001381 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1009464001382 DNA binding residues [nucleotide binding] 1009464001383 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 1009464001384 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 1009464001385 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 1009464001386 active site 1009464001387 DNA binding site [nucleotide binding] 1009464001388 catalytic site [active] 1009464001389 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 1009464001390 hypothetical protein; Provisional; Region: PRK14709 1009464001391 D5 N terminal like; Region: D5_N; pfam08706 1009464001392 VRR-NUC domain; Region: VRR_NUC; pfam08774 1009464001393 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1009464001394 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1009464001395 ATP binding site [chemical binding]; other site 1009464001396 putative Mg++ binding site [ion binding]; other site 1009464001397 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1009464001398 DNA binding residues [nucleotide binding] 1009464001399 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1009464001400 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 1009464001401 active site 1009464001402 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1009464001403 active site 1009464001404 Phage terminase, small subunit; Region: Terminase_4; cl01525 1009464001405 S-adenosylmethionine synthetase; Provisional; Region: PRK12459 1009464001406 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1009464001407 ParB-like nuclease domain; Region: ParBc; pfam02195 1009464001408 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1009464001409 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1009464001410 DNA methylase; Region: N6_N4_Mtase; pfam01555 1009464001411 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1009464001412 Phage-related protein [Function unknown]; Region: COG4695 1009464001413 Phage portal protein; Region: Phage_portal; pfam04860 1009464001414 Clp protease; Region: CLP_protease; pfam00574 1009464001415 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1009464001416 oligomer interface [polypeptide binding]; other site 1009464001417 active site residues [active] 1009464001418 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1009464001419 Phage capsid family; Region: Phage_capsid; pfam05065 1009464001420 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1009464001421 oligomerization interface [polypeptide binding]; other site 1009464001422 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1009464001423 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1009464001424 Phage-related protein [Function unknown]; Region: COG5412 1009464001425 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cl10033 1009464001426 epsilon subunit interface [polypeptide binding]; other site 1009464001427 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1009464001428 Holin family; Region: Phage_holin_4; pfam05105 1009464001429 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 1009464001430 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1009464001431 active site 1009464001432 Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; pfam08230 1009464001433 Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; pfam08230 1009464001434 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1009464001435 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1009464001436 catalytic residues [active] 1009464001437 catalytic nucleophile [active] 1009464001438 Recombinase; Region: Recombinase; pfam07508 1009464001439 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1009464001440 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1009464001441 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1009464001442 Coenzyme A binding pocket [chemical binding]; other site 1009464001443 RelB antitoxin; Region: RelB; cl01171 1009464001444 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1009464001445 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1009464001446 non-specific DNA binding site [nucleotide binding]; other site 1009464001447 salt bridge; other site 1009464001448 sequence-specific DNA binding site [nucleotide binding]; other site 1009464001449 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1009464001450 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1009464001451 non-specific DNA binding site [nucleotide binding]; other site 1009464001452 salt bridge; other site 1009464001453 sequence-specific DNA binding site [nucleotide binding]; other site 1009464001454 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1009464001455 non-specific DNA binding site [nucleotide binding]; other site 1009464001456 salt bridge; other site 1009464001457 sequence-specific DNA binding site [nucleotide binding]; other site 1009464001458 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1009464001459 RelB antitoxin; Region: RelB; cl01171 1009464001460 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1009464001461 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1009464001462 potential frameshift: common BLAST hit: gi|311114929|ref|YP_003986150.1| iron (Fe3+) ABC transporter ATP-binding protein 1009464001463 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009464001464 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009464001465 ABC transporter signature motif; other site 1009464001466 ABC transporter signature motif; other site 1009464001467 Walker B; other site 1009464001468 Walker B; other site 1009464001469 D-loop; other site 1009464001470 H-loop/switch region; other site 1009464001471 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1009464001472 RelB antitoxin; Region: RelB; cl01171 1009464001473 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1009464001474 AAA domain; Region: AAA_14; pfam13173 1009464001475 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1009464001476 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1009464001477 ligand binding site [chemical binding]; other site 1009464001478 flexible hinge region; other site 1009464001479 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1009464001480 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1009464001481 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1009464001482 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1009464001483 Walker A/P-loop; other site 1009464001484 ATP binding site [chemical binding]; other site 1009464001485 Q-loop/lid; other site 1009464001486 ABC transporter signature motif; other site 1009464001487 Walker B; other site 1009464001488 D-loop; other site 1009464001489 H-loop/switch region; other site 1009464001490 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1009464001491 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1009464001492 Walker A/P-loop; other site 1009464001493 ATP binding site [chemical binding]; other site 1009464001494 Q-loop/lid; other site 1009464001495 ABC transporter signature motif; other site 1009464001496 Walker B; other site 1009464001497 D-loop; other site 1009464001498 H-loop/switch region; other site 1009464001499 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1009464001500 active site 1009464001501 tetramer interface [polypeptide binding]; other site 1009464001502 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1009464001503 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009464001504 Walker A/P-loop; other site 1009464001505 ATP binding site [chemical binding]; other site 1009464001506 Q-loop/lid; other site 1009464001507 ABC transporter signature motif; other site 1009464001508 Walker B; other site 1009464001509 D-loop; other site 1009464001510 H-loop/switch region; other site 1009464001511 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1009464001512 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1009464001513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009464001514 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1009464001515 serine/threonine transporter SstT; Provisional; Region: PRK13628 1009464001516 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1009464001517 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1009464001518 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1009464001519 Coenzyme A binding pocket [chemical binding]; other site 1009464001520 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1009464001521 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1009464001522 serine O-acetyltransferase; Region: cysE; TIGR01172 1009464001523 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1009464001524 trimer interface [polypeptide binding]; other site 1009464001525 active site 1009464001526 substrate binding site [chemical binding]; other site 1009464001527 CoA binding site [chemical binding]; other site 1009464001528 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1009464001529 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1009464001530 dimer interface [polypeptide binding]; other site 1009464001531 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009464001532 catalytic residue [active] 1009464001533 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 1009464001534 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1009464001535 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1009464001536 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009464001537 Walker A/P-loop; other site 1009464001538 ATP binding site [chemical binding]; other site 1009464001539 Q-loop/lid; other site 1009464001540 ABC transporter signature motif; other site 1009464001541 Walker B; other site 1009464001542 D-loop; other site 1009464001543 H-loop/switch region; other site 1009464001544 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1009464001545 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1009464001546 Walker A/P-loop; other site 1009464001547 ATP binding site [chemical binding]; other site 1009464001548 Q-loop/lid; other site 1009464001549 ABC transporter signature motif; other site 1009464001550 Walker B; other site 1009464001551 D-loop; other site 1009464001552 H-loop/switch region; other site 1009464001553 Cobalt transport protein; Region: CbiQ; cl00463 1009464001554 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 1009464001555 LemA family; Region: LemA; cl00742 1009464001556 ambiguous bases; low coverage region 1009464001557 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1009464001558 classical (c) SDRs; Region: SDR_c; cd05233 1009464001559 NAD(P) binding site [chemical binding]; other site 1009464001560 active site 1009464001561 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 1009464001562 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1009464001563 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009464001564 Walker A/P-loop; other site 1009464001565 ATP binding site [chemical binding]; other site 1009464001566 Q-loop/lid; other site 1009464001567 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009464001568 ABC transporter signature motif; other site 1009464001569 Walker B; other site 1009464001570 D-loop; other site 1009464001571 H-loop/switch region; other site 1009464001572 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1009464001573 Predicted membrane protein [Function unknown]; Region: COG1511 1009464001574 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1009464001575 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1009464001576 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1009464001577 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1009464001578 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1009464001579 active site 1009464001580 NAD binding site [chemical binding]; other site 1009464001581 metal binding site [ion binding]; metal-binding site 1009464001582 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1009464001583 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1009464001584 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1009464001585 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1009464001586 HicB family; Region: HicB; pfam05534 1009464001587 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1009464001588 PAS fold; Region: PAS_4; pfam08448 1009464001589 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1009464001590 Histidine kinase; Region: HisKA_2; pfam07568 1009464001591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009464001592 ATP binding site [chemical binding]; other site 1009464001593 Mg2+ binding site [ion binding]; other site 1009464001594 G-X-G motif; other site 1009464001595 Transcription factor WhiB; Region: Whib; pfam02467 1009464001596 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1009464001597 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1009464001598 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1009464001599 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1009464001600 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1009464001601 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1009464001602 Eukaryotic phosphomannomutase; Region: PMM; cl17107 1009464001603 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1009464001604 active site 1009464001605 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1009464001606 dimerization interface [polypeptide binding]; other site 1009464001607 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1009464001608 dimer interface [polypeptide binding]; other site 1009464001609 phosphorylation site [posttranslational modification] 1009464001610 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009464001611 ATP binding site [chemical binding]; other site 1009464001612 Mg2+ binding site [ion binding]; other site 1009464001613 G-X-G motif; other site 1009464001614 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1009464001615 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009464001616 active site 1009464001617 phosphorylation site [posttranslational modification] 1009464001618 intermolecular recognition site; other site 1009464001619 dimerization interface [polypeptide binding]; other site 1009464001620 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1009464001621 DNA binding site [nucleotide binding] 1009464001622 glycogen branching enzyme; Provisional; Region: PRK05402 1009464001623 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1009464001624 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1009464001625 active site 1009464001626 catalytic site [active] 1009464001627 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1009464001628 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1009464001629 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1009464001630 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1009464001631 intersubunit interface [polypeptide binding]; other site 1009464001632 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1009464001633 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1009464001634 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1009464001635 homodimer interface [polypeptide binding]; other site 1009464001636 NADP binding site [chemical binding]; other site 1009464001637 substrate binding site [chemical binding]; other site 1009464001638 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1009464001639 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1009464001640 RNA binding site [nucleotide binding]; other site 1009464001641 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1009464001642 RNA binding site [nucleotide binding]; other site 1009464001643 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1009464001644 RNA binding site [nucleotide binding]; other site 1009464001645 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1009464001646 RNA binding site [nucleotide binding]; other site 1009464001647 TM2 domain; Region: TM2; pfam05154 1009464001648 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1009464001649 active site 1009464001650 TM2 domain; Region: TM2; pfam05154 1009464001651 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1009464001652 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1009464001653 CoA-binding site [chemical binding]; other site 1009464001654 ATP-binding [chemical binding]; other site 1009464001655 excinuclease ABC subunit B; Provisional; Region: PRK05298 1009464001656 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1009464001657 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1009464001658 nucleotide binding region [chemical binding]; other site 1009464001659 ATP-binding site [chemical binding]; other site 1009464001660 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1009464001661 UvrB/uvrC motif; Region: UVR; pfam02151 1009464001662 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 1009464001663 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1009464001664 domain interfaces; other site 1009464001665 active site 1009464001666 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1009464001667 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1009464001668 Substrate binding site; other site 1009464001669 Mg++ binding site; other site 1009464001670 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1009464001671 active site 1009464001672 substrate binding site [chemical binding]; other site 1009464001673 CoA binding site [chemical binding]; other site 1009464001674 Oligomerisation domain; Region: Oligomerisation; pfam02410 1009464001675 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1009464001676 catalytic core [active] 1009464001677 LytTr DNA-binding domain; Region: LytTR; pfam04397 1009464001678 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1009464001679 EamA-like transporter family; Region: EamA; pfam00892 1009464001680 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1009464001681 EamA-like transporter family; Region: EamA; pfam00892 1009464001682 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1009464001683 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1009464001684 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1009464001685 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 1009464001686 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1009464001687 catalytic loop [active] 1009464001688 iron binding site [ion binding]; other site 1009464001689 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1009464001690 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1009464001691 nucleotide binding site/active site [active] 1009464001692 HIT family signature motif; other site 1009464001693 catalytic residue [active] 1009464001694 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1009464001695 PhoH-like protein; Region: PhoH; pfam02562 1009464001696 metal-binding heat shock protein; Provisional; Region: PRK00016 1009464001697 FOG: CBS domain [General function prediction only]; Region: COG0517 1009464001698 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1009464001699 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1009464001700 GTPase Era; Reviewed; Region: era; PRK00089 1009464001701 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1009464001702 G1 box; other site 1009464001703 GTP/Mg2+ binding site [chemical binding]; other site 1009464001704 Switch I region; other site 1009464001705 G2 box; other site 1009464001706 Switch II region; other site 1009464001707 G3 box; other site 1009464001708 G4 box; other site 1009464001709 G5 box; other site 1009464001710 KH domain; Region: KH_2; pfam07650 1009464001711 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1009464001712 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1009464001713 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1009464001714 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1009464001715 acyl-activating enzyme (AAE) consensus motif; other site 1009464001716 putative AMP binding site [chemical binding]; other site 1009464001717 putative active site [active] 1009464001718 putative CoA binding site [chemical binding]; other site 1009464001719 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1009464001720 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1009464001721 5S rRNA interface [nucleotide binding]; other site 1009464001722 CTC domain interface [polypeptide binding]; other site 1009464001723 L16 interface [polypeptide binding]; other site 1009464001724 ambiguous bases; G vs T in a non-repeat region 1009464001725 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1009464001726 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1009464001727 PCRF domain; Region: PCRF; pfam03462 1009464001728 RF-1 domain; Region: RF-1; pfam00472 1009464001729 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1009464001730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009464001731 S-adenosylmethionine binding site [chemical binding]; other site 1009464001732 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1009464001733 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1009464001734 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1009464001735 Mg++ binding site [ion binding]; other site 1009464001736 putative catalytic motif [active] 1009464001737 substrate binding site [chemical binding]; other site 1009464001738 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1009464001739 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1009464001740 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1009464001741 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1009464001742 active site 1009464001743 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1009464001744 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1009464001745 catalytic site [active] 1009464001746 putative active site [active] 1009464001747 putative substrate binding site [chemical binding]; other site 1009464001748 dimer interface [polypeptide binding]; other site 1009464001749 PIF1-like helicase; Region: PIF1; pfam05970 1009464001750 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009464001751 Walker A motif; other site 1009464001752 ATP binding site [chemical binding]; other site 1009464001753 Walker B motif; other site 1009464001754 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1009464001755 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1009464001756 dimer interface [polypeptide binding]; other site 1009464001757 motif 1; other site 1009464001758 active site 1009464001759 motif 2; other site 1009464001760 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1009464001761 putative deacylase active site [active] 1009464001762 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1009464001763 active site 1009464001764 motif 3; other site 1009464001765 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1009464001766 anticodon binding site; other site 1009464001767 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1009464001768 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1009464001769 dimer interface [polypeptide binding]; other site 1009464001770 ssDNA binding site [nucleotide binding]; other site 1009464001771 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1009464001772 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1009464001773 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1009464001774 active site 1009464001775 Zn binding site [ion binding]; other site 1009464001776 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1009464001777 active site 1009464001778 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1009464001779 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1009464001780 RF-1 domain; Region: RF-1; pfam00472 1009464001781 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1009464001782 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009464001783 Walker A/P-loop; other site 1009464001784 ATP binding site [chemical binding]; other site 1009464001785 Q-loop/lid; other site 1009464001786 ABC transporter signature motif; other site 1009464001787 Walker B; other site 1009464001788 D-loop; other site 1009464001789 H-loop/switch region; other site 1009464001790 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1009464001791 FtsX-like permease family; Region: FtsX; pfam02687 1009464001792 CHAP domain; Region: CHAP; pfam05257 1009464001793 Surface antigen [General function prediction only]; Region: COG3942 1009464001794 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1009464001795 SmpB-tmRNA interface; other site 1009464001796 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009464001797 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1009464001798 substrate binding pocket [chemical binding]; other site 1009464001799 membrane-bound complex binding site; other site 1009464001800 hinge residues; other site 1009464001801 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1009464001802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464001803 dimer interface [polypeptide binding]; other site 1009464001804 conserved gate region; other site 1009464001805 putative PBP binding loops; other site 1009464001806 ABC-ATPase subunit interface; other site 1009464001807 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1009464001808 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1009464001809 Walker A/P-loop; other site 1009464001810 ATP binding site [chemical binding]; other site 1009464001811 Q-loop/lid; other site 1009464001812 ABC transporter signature motif; other site 1009464001813 Walker B; other site 1009464001814 D-loop; other site 1009464001815 H-loop/switch region; other site 1009464001816 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1009464001817 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1009464001818 glutaminase active site [active] 1009464001819 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1009464001820 dimer interface [polypeptide binding]; other site 1009464001821 active site 1009464001822 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1009464001823 dimer interface [polypeptide binding]; other site 1009464001824 active site 1009464001825 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1009464001826 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1009464001827 pantothenate kinase; Reviewed; Region: PRK13318 1009464001828 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1009464001829 homodimer interface [polypeptide binding]; other site 1009464001830 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1009464001831 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1009464001832 active site 1009464001833 homodimer interface [polypeptide binding]; other site 1009464001834 catalytic site [active] 1009464001835 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1009464001836 predicted active site [active] 1009464001837 catalytic triad [active] 1009464001838 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1009464001839 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1009464001840 active site 1009464001841 multimer interface [polypeptide binding]; other site 1009464001842 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1009464001843 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 1009464001844 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1009464001845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464001846 dimer interface [polypeptide binding]; other site 1009464001847 conserved gate region; other site 1009464001848 putative PBP binding loops; other site 1009464001849 ABC-ATPase subunit interface; other site 1009464001850 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1009464001851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464001852 dimer interface [polypeptide binding]; other site 1009464001853 conserved gate region; other site 1009464001854 putative PBP binding loops; other site 1009464001855 ABC-ATPase subunit interface; other site 1009464001856 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1009464001857 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1009464001858 Walker A/P-loop; other site 1009464001859 ATP binding site [chemical binding]; other site 1009464001860 Q-loop/lid; other site 1009464001861 ABC transporter signature motif; other site 1009464001862 Walker B; other site 1009464001863 D-loop; other site 1009464001864 H-loop/switch region; other site 1009464001865 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1009464001866 Walker A/P-loop; other site 1009464001867 ATP binding site [chemical binding]; other site 1009464001868 Q-loop/lid; other site 1009464001869 ABC transporter signature motif; other site 1009464001870 Walker B; other site 1009464001871 D-loop; other site 1009464001872 H-loop/switch region; other site 1009464001873 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1009464001874 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1009464001875 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1009464001876 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1009464001877 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1009464001878 active site 1009464001879 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1009464001880 dimer interface [polypeptide binding]; other site 1009464001881 substrate binding site [chemical binding]; other site 1009464001882 catalytic residues [active] 1009464001883 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1009464001884 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1009464001885 Zn2+ binding site [ion binding]; other site 1009464001886 Mg2+ binding site [ion binding]; other site 1009464001887 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1009464001888 DNA primase, catalytic core; Region: dnaG; TIGR01391 1009464001889 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1009464001890 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1009464001891 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1009464001892 active site 1009464001893 metal binding site [ion binding]; metal-binding site 1009464001894 interdomain interaction site; other site 1009464001895 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1009464001896 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 1009464001897 putative active cleft [active] 1009464001898 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 1009464001899 active site 1009464001900 catalytic site [active] 1009464001901 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 1009464001902 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 1009464001903 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1009464001904 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1009464001905 Walker A/P-loop; other site 1009464001906 ATP binding site [chemical binding]; other site 1009464001907 Q-loop/lid; other site 1009464001908 ABC transporter signature motif; other site 1009464001909 Walker B; other site 1009464001910 D-loop; other site 1009464001911 H-loop/switch region; other site 1009464001912 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1009464001913 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1009464001914 Walker A/P-loop; other site 1009464001915 ATP binding site [chemical binding]; other site 1009464001916 Q-loop/lid; other site 1009464001917 ABC transporter signature motif; other site 1009464001918 Walker B; other site 1009464001919 D-loop; other site 1009464001920 H-loop/switch region; other site 1009464001921 Cobalt transport protein; Region: CbiQ; cl00463 1009464001922 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1009464001923 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1009464001924 ligand binding site [chemical binding]; other site 1009464001925 flexible hinge region; other site 1009464001926 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1009464001927 non-specific DNA interactions [nucleotide binding]; other site 1009464001928 DNA binding site [nucleotide binding] 1009464001929 sequence specific DNA binding site [nucleotide binding]; other site 1009464001930 putative cAMP binding site [chemical binding]; other site 1009464001931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009464001932 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1009464001933 putative substrate translocation pore; other site 1009464001934 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 1009464001935 active site 1009464001936 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1009464001937 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 1009464001938 putative active site [active] 1009464001939 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1009464001940 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1009464001941 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1009464001942 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1009464001943 nucleotide binding site [chemical binding]; other site 1009464001944 acetolactate synthase; Reviewed; Region: PRK08322 1009464001945 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1009464001946 PYR/PP interface [polypeptide binding]; other site 1009464001947 dimer interface [polypeptide binding]; other site 1009464001948 TPP binding site [chemical binding]; other site 1009464001949 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1009464001950 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1009464001951 TPP-binding site [chemical binding]; other site 1009464001952 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1009464001953 transmembrane helices; other site 1009464001954 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1009464001955 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1009464001956 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1009464001957 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009464001958 DNA-binding site [nucleotide binding]; DNA binding site 1009464001959 UTRA domain; Region: UTRA; pfam07702 1009464001960 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1009464001961 GTP-binding protein LepA; Provisional; Region: PRK05433 1009464001962 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1009464001963 G1 box; other site 1009464001964 putative GEF interaction site [polypeptide binding]; other site 1009464001965 GTP/Mg2+ binding site [chemical binding]; other site 1009464001966 Switch I region; other site 1009464001967 G2 box; other site 1009464001968 G3 box; other site 1009464001969 Switch II region; other site 1009464001970 G4 box; other site 1009464001971 G5 box; other site 1009464001972 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1009464001973 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1009464001974 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1009464001975 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1009464001976 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1009464001977 FeS/SAM binding site; other site 1009464001978 HemN C-terminal domain; Region: HemN_C; pfam06969 1009464001979 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1009464001980 FtsX-like permease family; Region: FtsX; pfam02687 1009464001981 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1009464001982 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1009464001983 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1009464001984 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1009464001985 Walker A/P-loop; other site 1009464001986 ATP binding site [chemical binding]; other site 1009464001987 Q-loop/lid; other site 1009464001988 ABC transporter signature motif; other site 1009464001989 Walker B; other site 1009464001990 D-loop; other site 1009464001991 H-loop/switch region; other site 1009464001992 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1009464001993 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1009464001994 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1009464001995 NAD binding site [chemical binding]; other site 1009464001996 ATP-grasp domain; Region: ATP-grasp; pfam02222 1009464001997 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1009464001998 metal binding site 2 [ion binding]; metal-binding site 1009464001999 putative DNA binding helix; other site 1009464002000 metal binding site 1 [ion binding]; metal-binding site 1009464002001 dimer interface [polypeptide binding]; other site 1009464002002 structural Zn2+ binding site [ion binding]; other site 1009464002003 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1009464002004 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 1009464002005 Sulfatase; Region: Sulfatase; pfam00884 1009464002006 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1009464002007 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1009464002008 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1009464002009 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1009464002010 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1009464002011 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1009464002012 dimerization interface [polypeptide binding]; other site 1009464002013 putative ATP binding site [chemical binding]; other site 1009464002014 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1009464002015 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1009464002016 active site 1009464002017 tetramer interface [polypeptide binding]; other site 1009464002018 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1009464002019 active site 1009464002020 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 1009464002021 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1009464002022 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1009464002023 dimerization interface [polypeptide binding]; other site 1009464002024 ATP binding site [chemical binding]; other site 1009464002025 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1009464002026 dimerization interface [polypeptide binding]; other site 1009464002027 ATP binding site [chemical binding]; other site 1009464002028 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1009464002029 putative active site [active] 1009464002030 catalytic triad [active] 1009464002031 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1009464002032 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1009464002033 ATP binding site [chemical binding]; other site 1009464002034 active site 1009464002035 substrate binding site [chemical binding]; other site 1009464002036 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1009464002037 ATP-grasp domain; Region: ATP-grasp; pfam02222 1009464002038 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1009464002039 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1009464002040 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1009464002041 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1009464002042 Competence-damaged protein; Region: CinA; pfam02464 1009464002043 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1009464002044 recombinase A; Provisional; Region: recA; PRK09354 1009464002045 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1009464002046 hexamer interface [polypeptide binding]; other site 1009464002047 Walker A motif; other site 1009464002048 ATP binding site [chemical binding]; other site 1009464002049 Walker B motif; other site 1009464002050 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1009464002051 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1009464002052 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1009464002053 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009464002054 catalytic residue [active] 1009464002055 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1009464002056 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1009464002057 putative catalytic cysteine [active] 1009464002058 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1009464002059 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1009464002060 active site 1009464002061 (T/H)XGH motif; other site 1009464002062 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1009464002063 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1009464002064 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1009464002065 active site 1009464002066 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1009464002067 hypothetical protein; Validated; Region: PRK00110 1009464002068 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 1009464002069 active site 1009464002070 putative DNA-binding cleft [nucleotide binding]; other site 1009464002071 dimer interface [polypeptide binding]; other site 1009464002072 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1009464002073 RuvA N terminal domain; Region: RuvA_N; pfam01330 1009464002074 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1009464002075 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1009464002076 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009464002077 Walker A motif; other site 1009464002078 ATP binding site [chemical binding]; other site 1009464002079 Walker B motif; other site 1009464002080 arginine finger; other site 1009464002081 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1009464002082 Preprotein translocase subunit; Region: YajC; cl00806 1009464002083 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1009464002084 active site 1009464002085 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1009464002086 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1009464002087 purine monophosphate binding site [chemical binding]; other site 1009464002088 dimer interface [polypeptide binding]; other site 1009464002089 putative catalytic residues [active] 1009464002090 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1009464002091 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 1009464002092 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 1009464002093 amphipathic channel; other site 1009464002094 Asn-Pro-Ala signature motifs; other site 1009464002095 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1009464002096 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1009464002097 RNA binding surface [nucleotide binding]; other site 1009464002098 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1009464002099 active site 1009464002100 bifunctional cytidylate kinase/GTPase Der; Reviewed; Region: PRK09518 1009464002101 AAA domain; Region: AAA_17; pfam13207 1009464002102 Cytidylate kinase; Region: Cytidylate_kin; pfam02224 1009464002103 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1009464002104 G1 box; other site 1009464002105 GTP/Mg2+ binding site [chemical binding]; other site 1009464002106 Switch I region; other site 1009464002107 G2 box; other site 1009464002108 Switch II region; other site 1009464002109 G3 box; other site 1009464002110 G4 box; other site 1009464002111 G5 box; other site 1009464002112 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1009464002113 G1 box; other site 1009464002114 GTP/Mg2+ binding site [chemical binding]; other site 1009464002115 Switch I region; other site 1009464002116 G2 box; other site 1009464002117 G3 box; other site 1009464002118 Switch II region; other site 1009464002119 G4 box; other site 1009464002120 G5 box; other site 1009464002121 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1009464002122 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1009464002123 ATP binding site [chemical binding]; other site 1009464002124 putative Mg++ binding site [ion binding]; other site 1009464002125 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1009464002126 nucleotide binding region [chemical binding]; other site 1009464002127 ATP-binding site [chemical binding]; other site 1009464002128 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1009464002129 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 1009464002130 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1009464002131 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1009464002132 Walker A/P-loop; other site 1009464002133 ATP binding site [chemical binding]; other site 1009464002134 Q-loop/lid; other site 1009464002135 ABC transporter signature motif; other site 1009464002136 Walker B; other site 1009464002137 D-loop; other site 1009464002138 H-loop/switch region; other site 1009464002139 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1009464002140 Walker A/P-loop; other site 1009464002141 ATP binding site [chemical binding]; other site 1009464002142 Q-loop/lid; other site 1009464002143 ABC transporter signature motif; other site 1009464002144 Walker B; other site 1009464002145 D-loop; other site 1009464002146 H-loop/switch region; other site 1009464002147 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1009464002148 Predicted membrane protein [Function unknown]; Region: COG3601 1009464002149 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1009464002150 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1009464002151 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1009464002152 active site 1009464002153 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1009464002154 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1009464002155 NAD binding site [chemical binding]; other site 1009464002156 substrate binding site [chemical binding]; other site 1009464002157 catalytic Zn binding site [ion binding]; other site 1009464002158 tetramer interface [polypeptide binding]; other site 1009464002159 structural Zn binding site [ion binding]; other site 1009464002160 peroxiredoxin; Region: AhpC; TIGR03137 1009464002161 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1009464002162 dimer interface [polypeptide binding]; other site 1009464002163 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1009464002164 catalytic triad [active] 1009464002165 peroxidatic and resolving cysteines [active] 1009464002166 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1009464002167 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1009464002168 catalytic residue [active] 1009464002169 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1009464002170 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1009464002171 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009464002172 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1009464002173 dimerization interface [polypeptide binding]; other site 1009464002174 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1009464002175 binding surface 1009464002176 TPR motif; other site 1009464002177 Ligase N family; Region: LIGANc; smart00532 1009464002178 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1009464002179 nucleotide binding pocket [chemical binding]; other site 1009464002180 K-X-D-G motif; other site 1009464002181 catalytic site [active] 1009464002182 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1009464002183 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1009464002184 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 1009464002185 Helix-hairpin-helix motif; Region: HHH; pfam00633 1009464002186 helix-hairpin-helix signature motif; other site 1009464002187 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1009464002188 Dimer interface [polypeptide binding]; other site 1009464002189 Domain of unknown function DUF59; Region: DUF59; pfam01883 1009464002190 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1009464002191 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1009464002192 Walker A motif; other site 1009464002193 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1009464002194 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1009464002195 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1009464002196 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1009464002197 dimer interface [polypeptide binding]; other site 1009464002198 motif 1; other site 1009464002199 active site 1009464002200 motif 2; other site 1009464002201 motif 3; other site 1009464002202 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1009464002203 anticodon binding site; other site 1009464002204 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1009464002205 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1009464002206 dimer interface [polypeptide binding]; other site 1009464002207 anticodon binding site; other site 1009464002208 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1009464002209 motif 1; other site 1009464002210 dimer interface [polypeptide binding]; other site 1009464002211 active site 1009464002212 motif 2; other site 1009464002213 GAD domain; Region: GAD; pfam02938 1009464002214 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1009464002215 active site 1009464002216 motif 3; other site 1009464002217 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1009464002218 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1009464002219 Walker A/P-loop; other site 1009464002220 ATP binding site [chemical binding]; other site 1009464002221 Q-loop/lid; other site 1009464002222 ABC transporter signature motif; other site 1009464002223 Walker B; other site 1009464002224 D-loop; other site 1009464002225 H-loop/switch region; other site 1009464002226 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009464002227 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1009464002228 substrate binding pocket [chemical binding]; other site 1009464002229 membrane-bound complex binding site; other site 1009464002230 hinge residues; other site 1009464002231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464002232 dimer interface [polypeptide binding]; other site 1009464002233 conserved gate region; other site 1009464002234 ABC-ATPase subunit interface; other site 1009464002235 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1009464002236 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464002237 dimer interface [polypeptide binding]; other site 1009464002238 conserved gate region; other site 1009464002239 putative PBP binding loops; other site 1009464002240 ABC-ATPase subunit interface; other site 1009464002241 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1009464002242 active site 1009464002243 WYL domain; Region: WYL; pfam13280 1009464002244 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1009464002245 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1009464002246 ATP binding site [chemical binding]; other site 1009464002247 putative Mg++ binding site [ion binding]; other site 1009464002248 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1009464002249 nucleotide binding region [chemical binding]; other site 1009464002250 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1009464002251 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1009464002252 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1009464002253 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1009464002254 motif II; other site 1009464002255 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1009464002256 DNA binding residues [nucleotide binding] 1009464002257 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1009464002258 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1009464002259 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1009464002260 phosphopeptide binding site; other site 1009464002261 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1009464002262 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 1009464002263 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1009464002264 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1009464002265 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1009464002266 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1009464002267 substrate binding site [chemical binding]; other site 1009464002268 hexamer interface [polypeptide binding]; other site 1009464002269 metal binding site [ion binding]; metal-binding site 1009464002270 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1009464002271 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1009464002272 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1009464002273 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1009464002274 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1009464002275 hinge region; other site 1009464002276 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1009464002277 putative nucleotide binding site [chemical binding]; other site 1009464002278 uridine monophosphate binding site [chemical binding]; other site 1009464002279 homohexameric interface [polypeptide binding]; other site 1009464002280 elongation factor Ts; Provisional; Region: tsf; PRK09377 1009464002281 UBA/TS-N domain; Region: UBA; pfam00627 1009464002282 Elongation factor TS; Region: EF_TS; pfam00889 1009464002283 Elongation factor TS; Region: EF_TS; pfam00889 1009464002284 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1009464002285 rRNA interaction site [nucleotide binding]; other site 1009464002286 S8 interaction site; other site 1009464002287 putative laminin-1 binding site; other site 1009464002288 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1009464002289 active site 1009464002290 catalytic residues [active] 1009464002291 metal binding site [ion binding]; metal-binding site 1009464002292 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1009464002293 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1009464002294 acyl-activating enzyme (AAE) consensus motif; other site 1009464002295 putative AMP binding site [chemical binding]; other site 1009464002296 putative active site [active] 1009464002297 putative CoA binding site [chemical binding]; other site 1009464002298 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1009464002299 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1009464002300 active site 1009464002301 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14671 1009464002302 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1009464002303 GIY-YIG motif/motif A; other site 1009464002304 active site 1009464002305 catalytic site [active] 1009464002306 putative DNA binding site [nucleotide binding]; other site 1009464002307 metal binding site [ion binding]; metal-binding site 1009464002308 UvrB/uvrC motif; Region: UVR; pfam02151 1009464002309 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1009464002310 Helix-hairpin-helix motif; Region: HHH; pfam00633 1009464002311 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1009464002312 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1009464002313 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1009464002314 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1009464002315 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1009464002316 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009464002317 Walker A/P-loop; other site 1009464002318 ATP binding site [chemical binding]; other site 1009464002319 Q-loop/lid; other site 1009464002320 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1009464002321 ABC transporter signature motif; other site 1009464002322 Walker B; other site 1009464002323 D-loop; other site 1009464002324 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1009464002325 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1009464002326 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1009464002327 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009464002328 homodimer interface [polypeptide binding]; other site 1009464002329 catalytic residue [active] 1009464002330 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1009464002331 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1009464002332 nucleotide binding site [chemical binding]; other site 1009464002333 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1009464002334 active site 1009464002335 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1009464002336 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1009464002337 motif II; other site 1009464002338 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1009464002339 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1009464002340 putative active site [active] 1009464002341 substrate binding site [chemical binding]; other site 1009464002342 putative cosubstrate binding site; other site 1009464002343 catalytic site [active] 1009464002344 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1009464002345 substrate binding site [chemical binding]; other site 1009464002346 chaperone protein DnaJ; Provisional; Region: PRK14278 1009464002347 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1009464002348 HSP70 interaction site [polypeptide binding]; other site 1009464002349 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1009464002350 Zn binding sites [ion binding]; other site 1009464002351 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1009464002352 dimer interface [polypeptide binding]; other site 1009464002353 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1009464002354 HTH domain; Region: HTH_11; pfam08279 1009464002355 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1009464002356 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1009464002357 TPP-binding site [chemical binding]; other site 1009464002358 dimer interface [polypeptide binding]; other site 1009464002359 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1009464002360 PYR/PP interface [polypeptide binding]; other site 1009464002361 dimer interface [polypeptide binding]; other site 1009464002362 TPP binding site [chemical binding]; other site 1009464002363 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1009464002364 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1009464002365 putative active site [active] 1009464002366 transaldolase; Provisional; Region: PRK03903 1009464002367 catalytic residue [active] 1009464002368 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1009464002369 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1009464002370 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1009464002371 DNA binding residues [nucleotide binding] 1009464002372 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1009464002373 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 1009464002374 Cadmium resistance transporter; Region: Cad; pfam03596 1009464002375 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1009464002376 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1009464002377 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1009464002378 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1009464002379 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1009464002380 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1009464002381 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1009464002382 salt bridge; other site 1009464002383 non-specific DNA binding site [nucleotide binding]; other site 1009464002384 sequence-specific DNA binding site [nucleotide binding]; other site 1009464002385 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1009464002386 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1009464002387 active site 1009464002388 motif I; other site 1009464002389 motif II; other site 1009464002390 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1009464002391 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1009464002392 triosephosphate isomerase; Provisional; Region: PRK14565 1009464002393 substrate binding site [chemical binding]; other site 1009464002394 dimer interface [polypeptide binding]; other site 1009464002395 catalytic triad [active] 1009464002396 Phosphoglycerate kinase; Region: PGK; pfam00162 1009464002397 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1009464002398 substrate binding site [chemical binding]; other site 1009464002399 hinge regions; other site 1009464002400 ADP binding site [chemical binding]; other site 1009464002401 catalytic site [active] 1009464002402 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 1009464002403 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1009464002404 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1009464002405 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1009464002406 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1009464002407 shikimate binding site; other site 1009464002408 NAD(P) binding site [chemical binding]; other site 1009464002409 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1009464002410 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1009464002411 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1009464002412 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1009464002413 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1009464002414 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1009464002415 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1009464002416 catalytic site [active] 1009464002417 G-X2-G-X-G-K; other site 1009464002418 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1009464002419 active site 1009464002420 dimer interface [polypeptide binding]; other site 1009464002421 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1009464002422 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1009464002423 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1009464002424 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1009464002425 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1009464002426 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1009464002427 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1009464002428 IMP binding site; other site 1009464002429 dimer interface [polypeptide binding]; other site 1009464002430 partial ornithine binding site; other site 1009464002431 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1009464002432 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1009464002433 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1009464002434 catalytic site [active] 1009464002435 subunit interface [polypeptide binding]; other site 1009464002436 transcription antitermination factor NusB; Region: nusB; TIGR01951 1009464002437 putative RNA binding site [nucleotide binding]; other site 1009464002438 elongation factor P; Validated; Region: PRK00529 1009464002439 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1009464002440 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1009464002441 RNA binding site [nucleotide binding]; other site 1009464002442 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1009464002443 RNA binding site [nucleotide binding]; other site 1009464002444 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1009464002445 active site 1009464002446 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1009464002447 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1009464002448 heterodimer interface [polypeptide binding]; other site 1009464002449 active site 1009464002450 FMN binding site [chemical binding]; other site 1009464002451 homodimer interface [polypeptide binding]; other site 1009464002452 substrate binding site [chemical binding]; other site 1009464002453 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1009464002454 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1009464002455 FAD binding pocket [chemical binding]; other site 1009464002456 FAD binding motif [chemical binding]; other site 1009464002457 phosphate binding motif [ion binding]; other site 1009464002458 beta-alpha-beta structure motif; other site 1009464002459 NAD binding pocket [chemical binding]; other site 1009464002460 Iron coordination center [ion binding]; other site 1009464002461 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1009464002462 active site 1009464002463 dimer interface [polypeptide binding]; other site 1009464002464 dihydroorotase; Validated; Region: pyrC; PRK09357 1009464002465 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1009464002466 active site 1009464002467 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1009464002468 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1009464002469 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1009464002470 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 1009464002471 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1009464002472 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1009464002473 metal binding triad; other site 1009464002474 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1009464002475 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1009464002476 metal binding triad; other site 1009464002477 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1009464002478 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1009464002479 FAD binding site [chemical binding]; other site 1009464002480 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1009464002481 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1009464002482 THF binding site; other site 1009464002483 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1009464002484 substrate binding site [chemical binding]; other site 1009464002485 THF binding site; other site 1009464002486 zinc-binding site [ion binding]; other site 1009464002487 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1009464002488 catalytic core [active] 1009464002489 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1009464002490 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009464002491 UGMP family protein; Validated; Region: PRK09604 1009464002492 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1009464002493 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1009464002494 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1009464002495 Coenzyme A binding pocket [chemical binding]; other site 1009464002496 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1009464002497 Glycoprotease family; Region: Peptidase_M22; pfam00814 1009464002498 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1009464002499 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 1009464002500 Competence protein; Region: Competence; pfam03772 1009464002501 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1009464002502 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1009464002503 Helix-hairpin-helix motif; Region: HHH; pfam00633 1009464002504 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1009464002505 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1009464002506 HIGH motif; other site 1009464002507 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1009464002508 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1009464002509 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1009464002510 active site 1009464002511 KMSKS motif; other site 1009464002512 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1009464002513 tRNA binding surface [nucleotide binding]; other site 1009464002514 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 1009464002515 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1009464002516 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1009464002517 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1009464002518 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1009464002519 acyl-activating enzyme (AAE) consensus motif; other site 1009464002520 putative AMP binding site [chemical binding]; other site 1009464002521 putative active site [active] 1009464002522 putative CoA binding site [chemical binding]; other site 1009464002523 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1009464002524 Peptidase family M23; Region: Peptidase_M23; pfam01551 1009464002525 lysine transporter; Provisional; Region: PRK10836 1009464002526 Predicted membrane protein [Function unknown]; Region: COG2860 1009464002527 UPF0126 domain; Region: UPF0126; pfam03458 1009464002528 UPF0126 domain; Region: UPF0126; pfam03458 1009464002529 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1009464002530 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1009464002531 homodimer interface [polypeptide binding]; other site 1009464002532 substrate-cofactor binding pocket; other site 1009464002533 catalytic residue [active] 1009464002534 Protein of unknown function (DUF501); Region: DUF501; pfam04417 1009464002535 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1009464002536 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1009464002537 nucleotide binding site [chemical binding]; other site 1009464002538 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1009464002539 Septum formation initiator; Region: DivIC; pfam04977 1009464002540 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1009464002541 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1009464002542 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1009464002543 NAD binding site [chemical binding]; other site 1009464002544 dimer interface [polypeptide binding]; other site 1009464002545 substrate binding site [chemical binding]; other site 1009464002546 enolase; Provisional; Region: eno; PRK00077 1009464002547 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1009464002548 dimer interface [polypeptide binding]; other site 1009464002549 metal binding site [ion binding]; metal-binding site 1009464002550 substrate binding pocket [chemical binding]; other site 1009464002551 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1009464002552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464002553 dimer interface [polypeptide binding]; other site 1009464002554 conserved gate region; other site 1009464002555 putative PBP binding loops; other site 1009464002556 ABC-ATPase subunit interface; other site 1009464002557 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1009464002558 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1009464002559 membrane-bound complex binding site; other site 1009464002560 hinge residues; other site 1009464002561 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1009464002562 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1009464002563 Walker A/P-loop; other site 1009464002564 ATP binding site [chemical binding]; other site 1009464002565 Q-loop/lid; other site 1009464002566 ABC transporter signature motif; other site 1009464002567 Walker B; other site 1009464002568 D-loop; other site 1009464002569 H-loop/switch region; other site 1009464002570 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1009464002571 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1009464002572 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1009464002573 ATP binding site [chemical binding]; other site 1009464002574 putative Mg++ binding site [ion binding]; other site 1009464002575 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1009464002576 nucleotide binding region [chemical binding]; other site 1009464002577 ATP-binding site [chemical binding]; other site 1009464002578 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1009464002579 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1009464002580 putative active site [active] 1009464002581 catalytic residue [active] 1009464002582 NMT1/THI5 like; Region: NMT1; pfam09084 1009464002583 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 1009464002584 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1009464002585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464002586 dimer interface [polypeptide binding]; other site 1009464002587 conserved gate region; other site 1009464002588 putative PBP binding loops; other site 1009464002589 ABC-ATPase subunit interface; other site 1009464002590 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 1009464002591 Uncharacterized conserved protein [Function unknown]; Region: COG1615 1009464002592 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1009464002593 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1009464002594 Predicted membrane protein [Function unknown]; Region: COG2855 1009464002595 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1009464002596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1009464002597 GTP-binding protein YchF; Reviewed; Region: PRK09601 1009464002598 YchF GTPase; Region: YchF; cd01900 1009464002599 G1 box; other site 1009464002600 GTP/Mg2+ binding site [chemical binding]; other site 1009464002601 Switch I region; other site 1009464002602 G2 box; other site 1009464002603 Switch II region; other site 1009464002604 G3 box; other site 1009464002605 G4 box; other site 1009464002606 G5 box; other site 1009464002607 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1009464002608 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1009464002609 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1009464002610 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1009464002611 Histidine kinase; Region: HisKA_3; pfam07730 1009464002612 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1009464002613 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1009464002614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009464002615 active site 1009464002616 phosphorylation site [posttranslational modification] 1009464002617 intermolecular recognition site; other site 1009464002618 dimerization interface [polypeptide binding]; other site 1009464002619 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009464002620 DNA binding residues [nucleotide binding] 1009464002621 dimerization interface [polypeptide binding]; other site 1009464002622 Spc7 kinetochore protein; Region: Spc7; smart00787 1009464002623 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1009464002624 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1009464002625 FtsX-like permease family; Region: FtsX; pfam02687 1009464002626 FtsX-like permease family; Region: FtsX; pfam02687 1009464002627 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1009464002628 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1009464002629 Walker A/P-loop; other site 1009464002630 ATP binding site [chemical binding]; other site 1009464002631 Q-loop/lid; other site 1009464002632 ABC transporter signature motif; other site 1009464002633 Walker B; other site 1009464002634 D-loop; other site 1009464002635 H-loop/switch region; other site 1009464002636 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 1009464002637 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1009464002638 dimer interface [polypeptide binding]; other site 1009464002639 active site 1009464002640 metal binding site [ion binding]; metal-binding site 1009464002641 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1009464002642 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1009464002643 DNA binding site [nucleotide binding] 1009464002644 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1009464002645 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1009464002646 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1009464002647 metal binding site [ion binding]; metal-binding site 1009464002648 substrate binding pocket [chemical binding]; other site 1009464002649 short chain dehydrogenase; Provisional; Region: PRK08628 1009464002650 classical (c) SDRs; Region: SDR_c; cd05233 1009464002651 NAD(P) binding site [chemical binding]; other site 1009464002652 active site 1009464002653 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1009464002654 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009464002655 putative substrate translocation pore; other site 1009464002656 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1009464002657 Amidohydrolase; Region: Amidohydro_2; pfam04909 1009464002658 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1009464002659 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1009464002660 inhibitor site; inhibition site 1009464002661 active site 1009464002662 dimer interface [polypeptide binding]; other site 1009464002663 catalytic residue [active] 1009464002664 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1009464002665 thiS-thiF/thiG interaction site; other site 1009464002666 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1009464002667 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1009464002668 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1009464002669 active site 1009464002670 dimer interface [polypeptide binding]; other site 1009464002671 motif 1; other site 1009464002672 motif 2; other site 1009464002673 motif 3; other site 1009464002674 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1009464002675 anticodon binding site; other site 1009464002676 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1009464002677 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1009464002678 ABC-ATPase subunit interface; other site 1009464002679 dimer interface [polypeptide binding]; other site 1009464002680 putative PBP binding regions; other site 1009464002681 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1009464002682 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1009464002683 ABC-ATPase subunit interface; other site 1009464002684 dimer interface [polypeptide binding]; other site 1009464002685 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1009464002686 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1009464002687 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1009464002688 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1009464002689 intersubunit interface [polypeptide binding]; other site 1009464002690 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1009464002691 putative substrate binding site [chemical binding]; other site 1009464002692 putative ATP binding site [chemical binding]; other site 1009464002693 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1009464002694 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1009464002695 motif II; other site 1009464002696 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009464002697 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009464002698 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1009464002699 dimerization interface [polypeptide binding]; other site 1009464002700 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1009464002701 Helix-turn-helix domain; Region: HTH_17; pfam12728 1009464002702 GIY-YIG domain of uncharacterized bacterial protein structurally related to COG3410; Region: GIY-YIG_COG3410; cd10439 1009464002703 GIY-YIG motif/motif A; other site 1009464002704 putative active site [active] 1009464002705 putative metal binding site [ion binding]; other site 1009464002706 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 1009464002707 Uncharacterized conserved protein [Function unknown]; Region: COG3410 1009464002708 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1009464002709 Clp amino terminal domain; Region: Clp_N; pfam02861 1009464002710 Clp amino terminal domain; Region: Clp_N; pfam02861 1009464002711 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009464002712 Walker A motif; other site 1009464002713 ATP binding site [chemical binding]; other site 1009464002714 Walker B motif; other site 1009464002715 arginine finger; other site 1009464002716 UvrB/uvrC motif; Region: UVR; pfam02151 1009464002717 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009464002718 Walker A motif; other site 1009464002719 ATP binding site [chemical binding]; other site 1009464002720 Walker B motif; other site 1009464002721 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1009464002722 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1009464002723 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1009464002724 DNA-binding site [nucleotide binding]; DNA binding site 1009464002725 RNA-binding motif; other site 1009464002726 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1009464002727 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1009464002728 dimerization interface [polypeptide binding]; other site 1009464002729 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1009464002730 dimer interface [polypeptide binding]; other site 1009464002731 phosphorylation site [posttranslational modification] 1009464002732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009464002733 ATP binding site [chemical binding]; other site 1009464002734 Mg2+ binding site [ion binding]; other site 1009464002735 G-X-G motif; other site 1009464002736 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1009464002737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009464002738 active site 1009464002739 phosphorylation site [posttranslational modification] 1009464002740 intermolecular recognition site; other site 1009464002741 dimerization interface [polypeptide binding]; other site 1009464002742 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1009464002743 DNA binding site [nucleotide binding] 1009464002744 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1009464002745 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1009464002746 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1009464002747 ring oligomerisation interface [polypeptide binding]; other site 1009464002748 ATP/Mg binding site [chemical binding]; other site 1009464002749 stacking interactions; other site 1009464002750 hinge regions; other site 1009464002751 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1009464002752 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1009464002753 ligand binding site [chemical binding]; other site 1009464002754 active site 1009464002755 UGI interface [polypeptide binding]; other site 1009464002756 catalytic site [active] 1009464002757 MoxR-like ATPases [General function prediction only]; Region: COG0714 1009464002758 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1009464002759 Protein of unknown function DUF58; Region: DUF58; pfam01882 1009464002760 enhanced disease resistance protein (EDR2); Provisional; Region: PLN00188 1009464002761 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1009464002762 metal ion-dependent adhesion site (MIDAS); other site 1009464002763 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1009464002764 metal ion-dependent adhesion site (MIDAS); other site 1009464002765 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1009464002766 PGAP1-like protein; Region: PGAP1; pfam07819 1009464002767 adenylosuccinate lyase; Provisional; Region: PRK09285 1009464002768 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1009464002769 tetramer interface [polypeptide binding]; other site 1009464002770 active site 1009464002771 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1009464002772 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1009464002773 IHF dimer interface [polypeptide binding]; other site 1009464002774 IHF - DNA interface [nucleotide binding]; other site 1009464002775 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1009464002776 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1009464002777 oligomer interface [polypeptide binding]; other site 1009464002778 active site residues [active] 1009464002779 Clp protease; Region: CLP_protease; pfam00574 1009464002780 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1009464002781 oligomer interface [polypeptide binding]; other site 1009464002782 active site residues [active] 1009464002783 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1009464002784 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 1009464002785 Cl- selectivity filter; other site 1009464002786 Cl- binding residues [ion binding]; other site 1009464002787 pore gating glutamate residue; other site 1009464002788 dimer interface [polypeptide binding]; other site 1009464002789 trigger factor; Provisional; Region: tig; PRK01490 1009464002790 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1009464002791 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1009464002792 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1009464002793 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1009464002794 active site 1009464002795 catalytic site [active] 1009464002796 substrate binding site [chemical binding]; other site 1009464002797 HRDC domain; Region: HRDC; pfam00570 1009464002798 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1009464002799 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1009464002800 FeS/SAM binding site; other site 1009464002801 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1009464002802 Pyruvate formate lyase 1; Region: PFL1; cd01678 1009464002803 coenzyme A binding site [chemical binding]; other site 1009464002804 active site 1009464002805 catalytic residues [active] 1009464002806 glycine loop; other site 1009464002807 NAD synthetase; Provisional; Region: PRK13981 1009464002808 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1009464002809 multimer interface [polypeptide binding]; other site 1009464002810 active site 1009464002811 catalytic triad [active] 1009464002812 protein interface 1 [polypeptide binding]; other site 1009464002813 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1009464002814 homodimer interface [polypeptide binding]; other site 1009464002815 NAD binding pocket [chemical binding]; other site 1009464002816 ATP binding pocket [chemical binding]; other site 1009464002817 Mg binding site [ion binding]; other site 1009464002818 active-site loop [active] 1009464002819 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1009464002820 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1009464002821 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1009464002822 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1009464002823 Walker A/P-loop; other site 1009464002824 ATP binding site [chemical binding]; other site 1009464002825 Q-loop/lid; other site 1009464002826 ABC transporter signature motif; other site 1009464002827 Walker B; other site 1009464002828 D-loop; other site 1009464002829 H-loop/switch region; other site 1009464002830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464002831 dimer interface [polypeptide binding]; other site 1009464002832 conserved gate region; other site 1009464002833 putative PBP binding loops; other site 1009464002834 ABC-ATPase subunit interface; other site 1009464002835 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1009464002836 thiamine phosphate binding site [chemical binding]; other site 1009464002837 active site 1009464002838 pyrophosphate binding site [ion binding]; other site 1009464002839 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1009464002840 ThiC-associated domain; Region: ThiC-associated; pfam13667 1009464002841 ThiC family; Region: ThiC; pfam01964 1009464002842 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1009464002843 active site 1009464002844 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1009464002845 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1009464002846 Zn2+ binding site [ion binding]; other site 1009464002847 Mg2+ binding site [ion binding]; other site 1009464002848 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1009464002849 synthetase active site [active] 1009464002850 NTP binding site [chemical binding]; other site 1009464002851 metal binding site [ion binding]; metal-binding site 1009464002852 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1009464002853 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1009464002854 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1009464002855 trimer interface [polypeptide binding]; other site 1009464002856 active site 1009464002857 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1009464002858 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1009464002859 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1009464002860 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1009464002861 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1009464002862 CAP-like domain; other site 1009464002863 active site 1009464002864 primary dimer interface [polypeptide binding]; other site 1009464002865 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1009464002866 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1009464002867 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 1009464002868 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1009464002869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009464002870 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1009464002871 putative substrate translocation pore; other site 1009464002872 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 1009464002873 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 1009464002874 Protein of unknown function (DUF3791); Region: DUF3791; pfam12668 1009464002875 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1009464002876 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009464002877 ATP binding site [chemical binding]; other site 1009464002878 Mg2+ binding site [ion binding]; other site 1009464002879 G-X-G motif; other site 1009464002880 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1009464002881 anchoring element; other site 1009464002882 dimer interface [polypeptide binding]; other site 1009464002883 ATP binding site [chemical binding]; other site 1009464002884 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1009464002885 active site 1009464002886 putative metal-binding site [ion binding]; other site 1009464002887 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1009464002888 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1009464002889 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1009464002890 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1009464002891 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1009464002892 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1009464002893 DNA binding residues [nucleotide binding] 1009464002894 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1009464002895 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1009464002896 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1009464002897 substrate binding pocket [chemical binding]; other site 1009464002898 chain length determination region; other site 1009464002899 substrate-Mg2+ binding site; other site 1009464002900 catalytic residues [active] 1009464002901 aspartate-rich region 1; other site 1009464002902 active site lid residues [active] 1009464002903 aspartate-rich region 2; other site 1009464002904 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1009464002905 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1009464002906 active site 1009464002907 ATP binding site [chemical binding]; other site 1009464002908 substrate binding site [chemical binding]; other site 1009464002909 activation loop (A-loop); other site 1009464002910 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 1009464002911 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1009464002912 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1009464002913 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1009464002914 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1009464002915 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1009464002916 putative acyl-acceptor binding pocket; other site 1009464002917 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1009464002918 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1009464002919 ATP binding site [chemical binding]; other site 1009464002920 putative Mg++ binding site [ion binding]; other site 1009464002921 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1009464002922 SEC-C motif; Region: SEC-C; pfam02810 1009464002923 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1009464002924 30S subunit binding site; other site 1009464002925 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1009464002926 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1009464002927 motif II; other site 1009464002928 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1009464002929 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1009464002930 Walker A/P-loop; other site 1009464002931 ATP binding site [chemical binding]; other site 1009464002932 Q-loop/lid; other site 1009464002933 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1009464002934 ABC transporter signature motif; other site 1009464002935 Walker B; other site 1009464002936 D-loop; other site 1009464002937 H-loop/switch region; other site 1009464002938 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1009464002939 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1009464002940 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1009464002941 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1009464002942 RNA binding surface [nucleotide binding]; other site 1009464002943 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1009464002944 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1009464002945 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1009464002946 active site 1009464002947 motif I; other site 1009464002948 motif II; other site 1009464002949 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1009464002950 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1009464002951 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1009464002952 active site 1009464002953 HIGH motif; other site 1009464002954 dimer interface [polypeptide binding]; other site 1009464002955 KMSKS motif; other site 1009464002956 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1009464002957 RNA binding surface [nucleotide binding]; other site 1009464002958 argininosuccinate lyase; Provisional; Region: PRK00855 1009464002959 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1009464002960 active sites [active] 1009464002961 tetramer interface [polypeptide binding]; other site 1009464002962 argininosuccinate synthase; Provisional; Region: PRK13820 1009464002963 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1009464002964 ANP binding site [chemical binding]; other site 1009464002965 Substrate Binding Site II [chemical binding]; other site 1009464002966 Substrate Binding Site I [chemical binding]; other site 1009464002967 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1009464002968 Arginine repressor [Transcription]; Region: ArgR; COG1438 1009464002969 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1009464002970 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1009464002971 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1009464002972 putative tRNA-binding site [nucleotide binding]; other site 1009464002973 B3/4 domain; Region: B3_4; pfam03483 1009464002974 tRNA synthetase B5 domain; Region: B5; pfam03484 1009464002975 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1009464002976 dimer interface [polypeptide binding]; other site 1009464002977 motif 1; other site 1009464002978 motif 3; other site 1009464002979 motif 2; other site 1009464002980 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1009464002981 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1009464002982 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1009464002983 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1009464002984 dimer interface [polypeptide binding]; other site 1009464002985 motif 1; other site 1009464002986 active site 1009464002987 motif 2; other site 1009464002988 motif 3; other site 1009464002989 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1009464002990 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1009464002991 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1009464002992 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1009464002993 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1009464002994 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1009464002995 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 1009464002996 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 1009464002997 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1009464002998 active site 1009464002999 Ca binding site [ion binding]; other site 1009464003000 catalytic site [active] 1009464003001 Aamy_C domain; Region: Aamy_C; smart00632 1009464003002 GMP synthase; Reviewed; Region: guaA; PRK00074 1009464003003 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1009464003004 AMP/PPi binding site [chemical binding]; other site 1009464003005 candidate oxyanion hole; other site 1009464003006 catalytic triad [active] 1009464003007 potential glutamine specificity residues [chemical binding]; other site 1009464003008 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1009464003009 ATP Binding subdomain [chemical binding]; other site 1009464003010 Ligand Binding sites [chemical binding]; other site 1009464003011 Dimerization subdomain; other site 1009464003012 putative phosphoketolase; Provisional; Region: PRK05261 1009464003013 XFP N-terminal domain; Region: XFP_N; pfam09364 1009464003014 XFP C-terminal domain; Region: XFP_C; pfam09363 1009464003015 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1009464003016 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1009464003017 propionate/acetate kinase; Provisional; Region: PRK12379 1009464003018 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1009464003019 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1009464003020 hinge; other site 1009464003021 active site 1009464003022 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1009464003023 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1009464003024 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1009464003025 Walker A/P-loop; other site 1009464003026 ATP binding site [chemical binding]; other site 1009464003027 Q-loop/lid; other site 1009464003028 ABC transporter signature motif; other site 1009464003029 Walker B; other site 1009464003030 D-loop; other site 1009464003031 H-loop/switch region; other site 1009464003032 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1009464003033 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1009464003034 Walker A/P-loop; other site 1009464003035 ATP binding site [chemical binding]; other site 1009464003036 Q-loop/lid; other site 1009464003037 ABC transporter signature motif; other site 1009464003038 Walker B; other site 1009464003039 D-loop; other site 1009464003040 H-loop/switch region; other site 1009464003041 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 1009464003042 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1009464003043 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1009464003044 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1009464003045 active site 1009464003046 catalytic site [active] 1009464003047 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 1009464003048 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1009464003049 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1009464003050 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1009464003051 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1009464003052 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1009464003053 DNA protecting protein DprA; Region: dprA; TIGR00732 1009464003054 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 1009464003055 L-aspartate oxidase; Provisional; Region: PRK06175 1009464003056 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1009464003057 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1009464003058 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1009464003059 5'-3' exonuclease; Region: 53EXOc; smart00475 1009464003060 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1009464003061 active site 1009464003062 metal binding site 1 [ion binding]; metal-binding site 1009464003063 putative 5' ssDNA interaction site; other site 1009464003064 metal binding site 3; metal-binding site 1009464003065 metal binding site 2 [ion binding]; metal-binding site 1009464003066 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1009464003067 putative DNA binding site [nucleotide binding]; other site 1009464003068 putative metal binding site [ion binding]; other site 1009464003069 DNA polymerase I; Provisional; Region: PRK05755 1009464003070 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1009464003071 active site 1009464003072 substrate binding site [chemical binding]; other site 1009464003073 catalytic site [active] 1009464003074 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1009464003075 active site 1009464003076 DNA binding site [nucleotide binding] 1009464003077 catalytic site [active] 1009464003078 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1009464003079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009464003080 active site 1009464003081 phosphorylation site [posttranslational modification] 1009464003082 intermolecular recognition site; other site 1009464003083 dimerization interface [polypeptide binding]; other site 1009464003084 ANTAR domain; Region: ANTAR; pfam03861 1009464003085 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1009464003086 UbiA prenyltransferase family; Region: UbiA; pfam01040 1009464003087 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1009464003088 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1009464003089 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1009464003090 Walker A/P-loop; other site 1009464003091 ATP binding site [chemical binding]; other site 1009464003092 Q-loop/lid; other site 1009464003093 ABC transporter signature motif; other site 1009464003094 Walker B; other site 1009464003095 D-loop; other site 1009464003096 H-loop/switch region; other site 1009464003097 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1009464003098 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1009464003099 Walker A/P-loop; other site 1009464003100 ATP binding site [chemical binding]; other site 1009464003101 Q-loop/lid; other site 1009464003102 ABC transporter signature motif; other site 1009464003103 Walker B; other site 1009464003104 D-loop; other site 1009464003105 H-loop/switch region; other site 1009464003106 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1009464003107 substrate binding site [chemical binding]; other site 1009464003108 multimerization interface [polypeptide binding]; other site 1009464003109 ATP binding site [chemical binding]; other site 1009464003110 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1009464003111 thiamine phosphate binding site [chemical binding]; other site 1009464003112 active site 1009464003113 pyrophosphate binding site [ion binding]; other site 1009464003114 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1009464003115 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1009464003116 Walker A/P-loop; other site 1009464003117 ATP binding site [chemical binding]; other site 1009464003118 Q-loop/lid; other site 1009464003119 ABC transporter signature motif; other site 1009464003120 Walker B; other site 1009464003121 D-loop; other site 1009464003122 H-loop/switch region; other site 1009464003123 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1009464003124 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1009464003125 Walker A/P-loop; other site 1009464003126 ATP binding site [chemical binding]; other site 1009464003127 Q-loop/lid; other site 1009464003128 ABC transporter signature motif; other site 1009464003129 Walker B; other site 1009464003130 D-loop; other site 1009464003131 H-loop/switch region; other site 1009464003132 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1009464003133 hypothetical protein; Provisional; Region: PRK07907 1009464003134 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1009464003135 active site 1009464003136 metal binding site [ion binding]; metal-binding site 1009464003137 dimer interface [polypeptide binding]; other site 1009464003138 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1009464003139 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1009464003140 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1009464003141 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1009464003142 active site 1009464003143 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1009464003144 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1009464003145 folate binding site [chemical binding]; other site 1009464003146 NADP+ binding site [chemical binding]; other site 1009464003147 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1009464003148 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1009464003149 dimerization interface [polypeptide binding]; other site 1009464003150 active site 1009464003151 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1009464003152 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1009464003153 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1009464003154 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1009464003155 Ligand Binding Site [chemical binding]; other site 1009464003156 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1009464003157 NlpC/P60 family; Region: NLPC_P60; pfam00877 1009464003158 Surface antigen [General function prediction only]; Region: COG3942 1009464003159 CHAP domain; Region: CHAP; pfam05257 1009464003160 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1009464003161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009464003162 ATP binding site [chemical binding]; other site 1009464003163 Mg2+ binding site [ion binding]; other site 1009464003164 G-X-G motif; other site 1009464003165 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1009464003166 PhoU domain; Region: PhoU; pfam01895 1009464003167 PhoU domain; Region: PhoU; pfam01895 1009464003168 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1009464003169 catalytic core [active] 1009464003170 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1009464003171 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1009464003172 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1009464003173 dimer interface [polypeptide binding]; other site 1009464003174 putative anticodon binding site; other site 1009464003175 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1009464003176 motif 1; other site 1009464003177 dimer interface [polypeptide binding]; other site 1009464003178 active site 1009464003179 motif 2; other site 1009464003180 motif 3; other site 1009464003181 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1009464003182 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1009464003183 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1009464003184 binding surface 1009464003185 TPR motif; other site 1009464003186 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 1009464003187 Protein of unknown function (DUF4125); Region: DUF4125; pfam13526 1009464003188 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1009464003189 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1009464003190 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1009464003191 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1009464003192 active site 1009464003193 trimerization site [polypeptide binding]; other site 1009464003194 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1009464003195 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1009464003196 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1009464003197 catalytic residue [active] 1009464003198 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 1009464003199 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1009464003200 NAD binding site [chemical binding]; other site 1009464003201 dimer interface [polypeptide binding]; other site 1009464003202 substrate binding site [chemical binding]; other site 1009464003203 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1009464003204 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1009464003205 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1009464003206 HflX GTPase family; Region: HflX; cd01878 1009464003207 G1 box; other site 1009464003208 GTP/Mg2+ binding site [chemical binding]; other site 1009464003209 Switch I region; other site 1009464003210 G2 box; other site 1009464003211 G3 box; other site 1009464003212 Switch II region; other site 1009464003213 G4 box; other site 1009464003214 G5 box; other site 1009464003215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009464003216 S-adenosylmethionine binding site [chemical binding]; other site 1009464003217 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1009464003218 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1009464003219 ATP binding site [chemical binding]; other site 1009464003220 putative Mg++ binding site [ion binding]; other site 1009464003221 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1009464003222 nucleotide binding region [chemical binding]; other site 1009464003223 ATP-binding site [chemical binding]; other site 1009464003224 Helicase associated domain (HA2); Region: HA2; pfam04408 1009464003225 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1009464003226 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1009464003227 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1009464003228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009464003229 putative substrate translocation pore; other site 1009464003230 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1009464003231 active site 1009464003232 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1009464003233 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1009464003234 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1009464003235 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1009464003236 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1009464003237 active site 1009464003238 PHP Thumb interface [polypeptide binding]; other site 1009464003239 metal binding site [ion binding]; metal-binding site 1009464003240 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1009464003241 generic binding surface II; other site 1009464003242 generic binding surface I; other site 1009464003243 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1009464003244 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1009464003245 active site 1009464003246 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1009464003247 DivIVA protein; Region: DivIVA; pfam05103 1009464003248 DivIVA domain; Region: DivI1A_domain; TIGR03544 1009464003249 YGGT family; Region: YGGT; cl00508 1009464003250 Protein of unknown function (DUF552); Region: DUF552; pfam04472 1009464003251 cell division protein FtsZ; Validated; Region: PRK09330 1009464003252 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1009464003253 nucleotide binding site [chemical binding]; other site 1009464003254 SulA interaction site; other site 1009464003255 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1009464003256 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1009464003257 FMN binding site [chemical binding]; other site 1009464003258 active site 1009464003259 catalytic residues [active] 1009464003260 substrate binding site [chemical binding]; other site 1009464003261 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1009464003262 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1009464003263 motif 1; other site 1009464003264 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1009464003265 active site 1009464003266 motif 2; other site 1009464003267 motif 3; other site 1009464003268 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1009464003269 anticodon binding site; other site 1009464003270 Domain of unknown function DUF77; Region: DUF77; pfam01910 1009464003271 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1009464003272 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1009464003273 metal binding site [ion binding]; metal-binding site 1009464003274 putative dimer interface [polypeptide binding]; other site 1009464003275 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829 1009464003276 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1009464003277 catalytic residue [active] 1009464003278 putative FPP diphosphate binding site; other site 1009464003279 putative FPP binding hydrophobic cleft; other site 1009464003280 dimer interface [polypeptide binding]; other site 1009464003281 putative IPP diphosphate binding site; other site 1009464003282 Phosphotransferase enzyme family; Region: APH; pfam01636 1009464003283 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1009464003284 substrate binding site [chemical binding]; other site 1009464003285 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1009464003286 NMT1/THI5 like; Region: NMT1; pfam09084 1009464003287 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 1009464003288 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1009464003289 Recombination protein O N terminal; Region: RecO_N; pfam11967 1009464003290 Recombination protein O C terminal; Region: RecO_C; pfam02565 1009464003291 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 1009464003292 DivIVA domain; Region: DivI1A_domain; TIGR03544 1009464003293 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1009464003294 active site 1009464003295 catalytic site [active] 1009464003296 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1009464003297 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1009464003298 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1009464003299 Part of AAA domain; Region: AAA_19; pfam13245 1009464003300 Family description; Region: UvrD_C_2; pfam13538 1009464003301 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1009464003302 Phosphotransferase enzyme family; Region: APH; pfam01636 1009464003303 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1009464003304 substrate binding site [chemical binding]; other site 1009464003305 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1009464003306 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1009464003307 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1009464003308 active site 1009464003309 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1009464003310 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1009464003311 putative active site [active] 1009464003312 redox center [active] 1009464003313 glutamate racemase; Provisional; Region: PRK00865 1009464003314 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1009464003315 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1009464003316 Walker A/P-loop; other site 1009464003317 ATP binding site [chemical binding]; other site 1009464003318 Q-loop/lid; other site 1009464003319 ABC transporter signature motif; other site 1009464003320 Walker B; other site 1009464003321 D-loop; other site 1009464003322 H-loop/switch region; other site 1009464003323 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1009464003324 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1009464003325 Walker A/P-loop; other site 1009464003326 ATP binding site [chemical binding]; other site 1009464003327 Q-loop/lid; other site 1009464003328 ABC transporter signature motif; other site 1009464003329 Walker B; other site 1009464003330 D-loop; other site 1009464003331 H-loop/switch region; other site 1009464003332 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1009464003333 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 1009464003334 peptide binding site [polypeptide binding]; other site 1009464003335 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1009464003336 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1009464003337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464003338 dimer interface [polypeptide binding]; other site 1009464003339 conserved gate region; other site 1009464003340 putative PBP binding loops; other site 1009464003341 ABC-ATPase subunit interface; other site 1009464003342 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1009464003343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464003344 dimer interface [polypeptide binding]; other site 1009464003345 conserved gate region; other site 1009464003346 putative PBP binding loops; other site 1009464003347 ABC-ATPase subunit interface; other site 1009464003348 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 1009464003349 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1009464003350 HIGH motif; other site 1009464003351 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1009464003352 active site 1009464003353 KMSKS motif; other site 1009464003354 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1009464003355 tRNA binding surface [nucleotide binding]; other site 1009464003356 anticodon binding site; other site 1009464003357 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1009464003358 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1009464003359 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1009464003360 generic binding surface II; other site 1009464003361 generic binding surface I; other site 1009464003362 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 1009464003363 putative active site [active] 1009464003364 catalytic triad [active] 1009464003365 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 1009464003366 PA/protease or protease-like domain interface [polypeptide binding]; other site 1009464003367 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1009464003368 catalytic residues [active] 1009464003369 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 1009464003370 elongation factor Tu; Reviewed; Region: PRK00049 1009464003371 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1009464003372 G1 box; other site 1009464003373 GEF interaction site [polypeptide binding]; other site 1009464003374 GTP/Mg2+ binding site [chemical binding]; other site 1009464003375 Switch I region; other site 1009464003376 G2 box; other site 1009464003377 G3 box; other site 1009464003378 Switch II region; other site 1009464003379 G4 box; other site 1009464003380 G5 box; other site 1009464003381 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1009464003382 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1009464003383 Antibiotic Binding Site [chemical binding]; other site 1009464003384 elongation factor G; Reviewed; Region: PRK00007 1009464003385 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1009464003386 G1 box; other site 1009464003387 putative GEF interaction site [polypeptide binding]; other site 1009464003388 GTP/Mg2+ binding site [chemical binding]; other site 1009464003389 Switch I region; other site 1009464003390 G2 box; other site 1009464003391 G3 box; other site 1009464003392 Switch II region; other site 1009464003393 G4 box; other site 1009464003394 G5 box; other site 1009464003395 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1009464003396 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1009464003397 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1009464003398 30S ribosomal protein S7; Validated; Region: PRK05302 1009464003399 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1009464003400 S17 interaction site [polypeptide binding]; other site 1009464003401 S8 interaction site; other site 1009464003402 16S rRNA interaction site [nucleotide binding]; other site 1009464003403 streptomycin interaction site [chemical binding]; other site 1009464003404 23S rRNA interaction site [nucleotide binding]; other site 1009464003405 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1009464003406 cell division protein FtsQ; Provisional; Region: PRK05529 1009464003407 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1009464003408 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1009464003409 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1009464003410 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1009464003411 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1009464003412 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1009464003413 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1009464003414 active site 1009464003415 homodimer interface [polypeptide binding]; other site 1009464003416 cell division protein FtsW; Region: ftsW; TIGR02614 1009464003417 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 1009464003418 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1009464003419 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1009464003420 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1009464003421 Mg++ binding site [ion binding]; other site 1009464003422 putative catalytic motif [active] 1009464003423 putative substrate binding site [chemical binding]; other site 1009464003424 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1009464003425 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 1009464003426 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1009464003427 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1009464003428 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1009464003429 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1009464003430 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1009464003431 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1009464003432 MraW methylase family; Region: Methyltransf_5; cl17771 1009464003433 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1009464003434 MraZ protein; Region: MraZ; pfam02381 1009464003435 cell division protein MraZ; Reviewed; Region: PRK00326 1009464003436 MraZ protein; Region: MraZ; pfam02381 1009464003437 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1009464003438 Part of AAA domain; Region: AAA_19; pfam13245 1009464003439 Family description; Region: UvrD_C_2; pfam13538 1009464003440 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1009464003441 ATP cone domain; Region: ATP-cone; pfam03477 1009464003442 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1009464003443 LexA repressor; Validated; Region: PRK00215 1009464003444 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1009464003445 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1009464003446 Catalytic site [active] 1009464003447 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1009464003448 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1009464003449 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1009464003450 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1009464003451 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1009464003452 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1009464003453 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1009464003454 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1009464003455 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1009464003456 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1009464003457 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1009464003458 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1009464003459 DNA binding site [nucleotide binding] 1009464003460 domain linker motif; other site 1009464003461 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1009464003462 dimerization interface [polypeptide binding]; other site 1009464003463 ligand binding site [chemical binding]; other site 1009464003464 KIAA1161 is an uncharacterized Homo sapiens protein with a glycosyl hydrolase family 31 (GH31) domain that is homologous to the Escherichia coli YihQ glucosidase. Orthologs of KIA1161 are found in eukaryotes and prokaryotes. In bacteria, YihQ (along with...; Region: GH31_glucosidase_KIAA1161; cd06592 1009464003465 putative active site [active] 1009464003466 putative catalytic site [active] 1009464003467 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1009464003468 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1009464003469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464003470 dimer interface [polypeptide binding]; other site 1009464003471 conserved gate region; other site 1009464003472 putative PBP binding loops; other site 1009464003473 ABC-ATPase subunit interface; other site 1009464003474 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1009464003475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464003476 dimer interface [polypeptide binding]; other site 1009464003477 conserved gate region; other site 1009464003478 putative PBP binding loops; other site 1009464003479 ABC-ATPase subunit interface; other site 1009464003480 GA module; Region: GA; smart00844 1009464003481 FemAB family; Region: FemAB; pfam02388 1009464003482 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1009464003483 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1009464003484 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009464003485 Walker A/P-loop; other site 1009464003486 ATP binding site [chemical binding]; other site 1009464003487 Q-loop/lid; other site 1009464003488 ABC transporter signature motif; other site 1009464003489 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1009464003490 ABC transporter; Region: ABC_tran_2; pfam12848 1009464003491 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1009464003492 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1009464003493 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1009464003494 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1009464003495 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009464003496 Walker A motif; other site 1009464003497 ATP binding site [chemical binding]; other site 1009464003498 Walker B motif; other site 1009464003499 arginine finger; other site 1009464003500 Peptidase family M41; Region: Peptidase_M41; pfam01434 1009464003501 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1009464003502 active site 1009464003503 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1009464003504 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1009464003505 Ligand Binding Site [chemical binding]; other site 1009464003506 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1009464003507 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1009464003508 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1009464003509 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1009464003510 Walker A/P-loop; other site 1009464003511 ATP binding site [chemical binding]; other site 1009464003512 Q-loop/lid; other site 1009464003513 ABC transporter signature motif; other site 1009464003514 Walker B; other site 1009464003515 D-loop; other site 1009464003516 H-loop/switch region; other site 1009464003517 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1009464003518 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 1009464003519 DXD motif; other site 1009464003520 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1009464003521 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1009464003522 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1009464003523 glutamine synthetase, type I; Region: GlnA; TIGR00653 1009464003524 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1009464003525 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1009464003526 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1009464003527 active site 1009464003528 catalytic residues [active] 1009464003529 metal binding site [ion binding]; metal-binding site 1009464003530 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1009464003531 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1009464003532 active site 1009464003533 substrate binding site [chemical binding]; other site 1009464003534 metal binding site [ion binding]; metal-binding site 1009464003535 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1009464003536 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1009464003537 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1009464003538 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1009464003539 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1009464003540 Walker A/P-loop; other site 1009464003541 ATP binding site [chemical binding]; other site 1009464003542 Q-loop/lid; other site 1009464003543 ABC transporter signature motif; other site 1009464003544 Walker B; other site 1009464003545 D-loop; other site 1009464003546 H-loop/switch region; other site 1009464003547 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1009464003548 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1009464003549 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009464003550 Walker A/P-loop; other site 1009464003551 ATP binding site [chemical binding]; other site 1009464003552 Q-loop/lid; other site 1009464003553 ABC transporter signature motif; other site 1009464003554 Walker B; other site 1009464003555 D-loop; other site 1009464003556 H-loop/switch region; other site 1009464003557 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1009464003558 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1009464003559 FeS/SAM binding site; other site 1009464003560 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1009464003561 ATP cone domain; Region: ATP-cone; pfam03477 1009464003562 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1009464003563 effector binding site; other site 1009464003564 active site 1009464003565 Zn binding site [ion binding]; other site 1009464003566 glycine loop; other site 1009464003567 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1009464003568 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1009464003569 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1009464003570 ATP binding site [chemical binding]; other site 1009464003571 putative Mg++ binding site [ion binding]; other site 1009464003572 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1009464003573 nucleotide binding region [chemical binding]; other site 1009464003574 ATP-binding site [chemical binding]; other site 1009464003575 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1009464003576 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1009464003577 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1009464003578 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1009464003579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009464003580 putative substrate translocation pore; other site 1009464003581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009464003582 putative substrate translocation pore; other site 1009464003583 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1009464003584 G5 domain; Region: G5; pfam07501 1009464003585 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1009464003586 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1009464003587 catalytic residue [active] 1009464003588 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1009464003589 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1009464003590 catalytic residues [active] 1009464003591 seryl-tRNA synthetase; Provisional; Region: PRK05431 1009464003592 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1009464003593 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1009464003594 dimer interface [polypeptide binding]; other site 1009464003595 active site 1009464003596 motif 1; other site 1009464003597 motif 2; other site 1009464003598 motif 3; other site 1009464003599 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1009464003600 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1009464003601 UDP-galactopyranose mutase; Region: GLF; pfam03275 1009464003602 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1009464003603 active site 1009464003604 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1009464003605 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 1009464003606 active site 1009464003607 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1009464003608 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1009464003609 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1009464003610 active site 1009464003611 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 1009464003612 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1009464003613 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1009464003614 active site 1009464003615 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1009464003616 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009464003617 NAD(P) binding site [chemical binding]; other site 1009464003618 active site 1009464003619 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1009464003620 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1009464003621 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1009464003622 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1009464003623 Walker A/P-loop; other site 1009464003624 ATP binding site [chemical binding]; other site 1009464003625 Q-loop/lid; other site 1009464003626 ABC transporter signature motif; other site 1009464003627 Walker B; other site 1009464003628 D-loop; other site 1009464003629 H-loop/switch region; other site 1009464003630 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1009464003631 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1009464003632 NAD binding site [chemical binding]; other site 1009464003633 substrate binding site [chemical binding]; other site 1009464003634 homodimer interface [polypeptide binding]; other site 1009464003635 active site 1009464003636 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1009464003637 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 1009464003638 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1009464003639 NADP binding site [chemical binding]; other site 1009464003640 active site 1009464003641 putative substrate binding site [chemical binding]; other site 1009464003642 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1009464003643 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1009464003644 substrate binding site; other site 1009464003645 tetramer interface; other site 1009464003646 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1009464003647 active site 1009464003648 dimerization interface [polypeptide binding]; other site 1009464003649 ribonuclease PH; Reviewed; Region: rph; PRK00173 1009464003650 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1009464003651 hexamer interface [polypeptide binding]; other site 1009464003652 active site 1009464003653 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1009464003654 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1009464003655 ABC transporter; Region: ABC_tran_2; pfam12848 1009464003656 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1009464003657 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1009464003658 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1009464003659 quinone interaction residues [chemical binding]; other site 1009464003660 active site 1009464003661 catalytic residues [active] 1009464003662 FMN binding site [chemical binding]; other site 1009464003663 substrate binding site [chemical binding]; other site 1009464003664 Transglycosylase; Region: Transgly; pfam00912 1009464003665 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1009464003666 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1009464003667 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1009464003668 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1009464003669 ligand binding site [chemical binding]; other site 1009464003670 flexible hinge region; other site 1009464003671 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1009464003672 putative switch regulator; other site 1009464003673 non-specific DNA interactions [nucleotide binding]; other site 1009464003674 DNA binding site [nucleotide binding] 1009464003675 sequence specific DNA binding site [nucleotide binding]; other site 1009464003676 putative cAMP binding site [chemical binding]; other site 1009464003677 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1009464003678 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1009464003679 Uncharacterized conserved protein [Function unknown]; Region: COG4850 1009464003680 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 1009464003681 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1009464003682 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1009464003683 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1009464003684 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1009464003685 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1009464003686 phosphoglucomutase; Validated; Region: PRK07564 1009464003687 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1009464003688 active site 1009464003689 substrate binding site [chemical binding]; other site 1009464003690 metal binding site [ion binding]; metal-binding site 1009464003691 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1009464003692 RNA/DNA hybrid binding site [nucleotide binding]; other site 1009464003693 active site 1009464003694 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1009464003695 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1009464003696 active site 1009464003697 dimer interface [polypeptide binding]; other site 1009464003698 DNA repair protein RadA; Provisional; Region: PRK11823 1009464003699 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1009464003700 Walker A motif; other site 1009464003701 ATP binding site [chemical binding]; other site 1009464003702 Walker B motif; other site 1009464003703 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1009464003704 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1009464003705 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1009464003706 NAD binding site [chemical binding]; other site 1009464003707 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 1009464003708 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1009464003709 active site 1009464003710 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 1009464003711 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1009464003712 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1009464003713 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009464003714 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1009464003715 substrate binding pocket [chemical binding]; other site 1009464003716 membrane-bound complex binding site; other site 1009464003717 hinge residues; other site 1009464003718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464003719 dimer interface [polypeptide binding]; other site 1009464003720 conserved gate region; other site 1009464003721 putative PBP binding loops; other site 1009464003722 ABC-ATPase subunit interface; other site 1009464003723 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1009464003724 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1009464003725 Walker A/P-loop; other site 1009464003726 ATP binding site [chemical binding]; other site 1009464003727 Q-loop/lid; other site 1009464003728 ABC transporter signature motif; other site 1009464003729 Walker B; other site 1009464003730 D-loop; other site 1009464003731 H-loop/switch region; other site 1009464003732 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1009464003733 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1009464003734 active site 1009464003735 catalytic tetrad [active] 1009464003736 L-arabinose isomerase; Provisional; Region: PRK02929 1009464003737 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1009464003738 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1009464003739 trimer interface [polypeptide binding]; other site 1009464003740 substrate binding site [chemical binding]; other site 1009464003741 Mn binding site [ion binding]; other site 1009464003742 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 1009464003743 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1009464003744 intersubunit interface [polypeptide binding]; other site 1009464003745 active site 1009464003746 Zn2+ binding site [ion binding]; other site 1009464003747 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 1009464003748 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1009464003749 putative N- and C-terminal domain interface [polypeptide binding]; other site 1009464003750 putative active site [active] 1009464003751 MgATP binding site [chemical binding]; other site 1009464003752 catalytic site [active] 1009464003753 metal binding site [ion binding]; metal-binding site 1009464003754 putative carbohydrate binding site [chemical binding]; other site 1009464003755 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1009464003756 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1009464003757 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1009464003758 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1009464003759 TM-ABC transporter signature motif; other site 1009464003760 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1009464003761 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1009464003762 Walker A/P-loop; other site 1009464003763 ATP binding site [chemical binding]; other site 1009464003764 Q-loop/lid; other site 1009464003765 ABC transporter signature motif; other site 1009464003766 Walker B; other site 1009464003767 D-loop; other site 1009464003768 H-loop/switch region; other site 1009464003769 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1009464003770 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 1009464003771 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1009464003772 putative ligand binding site [chemical binding]; other site 1009464003773 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1009464003774 putative DNA binding site [nucleotide binding]; other site 1009464003775 putative Zn2+ binding site [ion binding]; other site 1009464003776 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1009464003777 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1009464003778 nucleotide binding site [chemical binding]; other site 1009464003779 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1009464003780 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1009464003781 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1009464003782 Walker A/P-loop; other site 1009464003783 ATP binding site [chemical binding]; other site 1009464003784 ABC transporter signature motif; other site 1009464003785 Walker B; other site 1009464003786 D-loop; other site 1009464003787 H-loop/switch region; other site 1009464003788 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1009464003789 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1009464003790 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1009464003791 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1009464003792 mRNA/rRNA interface [nucleotide binding]; other site 1009464003793 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1009464003794 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1009464003795 L7/L12 interface [polypeptide binding]; other site 1009464003796 23S rRNA interface [nucleotide binding]; other site 1009464003797 L25 interface [polypeptide binding]; other site 1009464003798 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1009464003799 core dimer interface [polypeptide binding]; other site 1009464003800 peripheral dimer interface [polypeptide binding]; other site 1009464003801 L10 interface [polypeptide binding]; other site 1009464003802 L11 interface [polypeptide binding]; other site 1009464003803 putative EF-Tu interaction site [polypeptide binding]; other site 1009464003804 putative EF-G interaction site [polypeptide binding]; other site 1009464003805 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1009464003806 23S rRNA interface [nucleotide binding]; other site 1009464003807 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1009464003808 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1009464003809 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1009464003810 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1009464003811 Walker A/P-loop; other site 1009464003812 ATP binding site [chemical binding]; other site 1009464003813 Q-loop/lid; other site 1009464003814 ABC transporter signature motif; other site 1009464003815 Walker B; other site 1009464003816 D-loop; other site 1009464003817 H-loop/switch region; other site 1009464003818 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1009464003819 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464003820 dimer interface [polypeptide binding]; other site 1009464003821 conserved gate region; other site 1009464003822 putative PBP binding loops; other site 1009464003823 ABC-ATPase subunit interface; other site 1009464003824 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1009464003825 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464003826 dimer interface [polypeptide binding]; other site 1009464003827 conserved gate region; other site 1009464003828 putative PBP binding loops; other site 1009464003829 ABC-ATPase subunit interface; other site 1009464003830 PBP superfamily domain; Region: PBP_like_2; cl17296 1009464003831 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1009464003832 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1009464003833 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1009464003834 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1009464003835 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1009464003836 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1009464003837 active site 1009464003838 Riboflavin kinase; Region: Flavokinase; pfam01687 1009464003839 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1009464003840 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 1009464003841 RNA binding site [nucleotide binding]; other site 1009464003842 active site 1009464003843 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1009464003844 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1009464003845 Rubella capsid protein; Region: Rubella_Capsid; pfam05750 1009464003846 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1009464003847 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1009464003848 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1009464003849 G1 box; other site 1009464003850 putative GEF interaction site [polypeptide binding]; other site 1009464003851 GTP/Mg2+ binding site [chemical binding]; other site 1009464003852 Switch I region; other site 1009464003853 G2 box; other site 1009464003854 G3 box; other site 1009464003855 Switch II region; other site 1009464003856 G4 box; other site 1009464003857 G5 box; other site 1009464003858 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1009464003859 Translation-initiation factor 2; Region: IF-2; pfam11987 1009464003860 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1009464003861 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1009464003862 NusA N-terminal domain; Region: NusA_N; pfam08529 1009464003863 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1009464003864 RNA binding site [nucleotide binding]; other site 1009464003865 homodimer interface [polypeptide binding]; other site 1009464003866 NusA-like KH domain; Region: KH_5; pfam13184 1009464003867 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1009464003868 G-X-X-G motif; other site 1009464003869 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1009464003870 trimer interface [polypeptide binding]; other site 1009464003871 active site 1009464003872 G bulge; other site 1009464003873 putative mechanosensitive channel protein; Provisional; Region: PRK10929 1009464003874 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1009464003875 putative substrate binding pocket [chemical binding]; other site 1009464003876 AC domain interface; other site 1009464003877 catalytic triad [active] 1009464003878 AB domain interface; other site 1009464003879 interchain disulfide; other site 1009464003880 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1009464003881 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1009464003882 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1009464003883 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1009464003884 active site 1009464003885 catalytic tetrad [active] 1009464003886 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1009464003887 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1009464003888 oligomer interface [polypeptide binding]; other site 1009464003889 RNA binding site [nucleotide binding]; other site 1009464003890 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1009464003891 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1009464003892 RNase E interface [polypeptide binding]; other site 1009464003893 trimer interface [polypeptide binding]; other site 1009464003894 active site 1009464003895 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1009464003896 putative nucleic acid binding region [nucleotide binding]; other site 1009464003897 G-X-X-G motif; other site 1009464003898 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1009464003899 RNA binding site [nucleotide binding]; other site 1009464003900 domain interface; other site 1009464003901 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1009464003902 16S/18S rRNA binding site [nucleotide binding]; other site 1009464003903 S13e-L30e interaction site [polypeptide binding]; other site 1009464003904 25S rRNA binding site [nucleotide binding]; other site 1009464003905 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1009464003906 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1009464003907 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1009464003908 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1009464003909 active site 1009464003910 ATP binding site [chemical binding]; other site 1009464003911 substrate binding site [chemical binding]; other site 1009464003912 activation loop (A-loop); other site 1009464003913 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1009464003914 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1009464003915 hinge; other site 1009464003916 active site 1009464003917 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 1009464003918 putative active site [active] 1009464003919 putative metal binding site [ion binding]; other site 1009464003920 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1009464003921 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1009464003922 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1009464003923 putative homodimer interface [polypeptide binding]; other site 1009464003924 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1009464003925 heterodimer interface [polypeptide binding]; other site 1009464003926 homodimer interface [polypeptide binding]; other site 1009464003927 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1009464003928 aspartate aminotransferase; Provisional; Region: PRK05764 1009464003929 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1009464003930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009464003931 homodimer interface [polypeptide binding]; other site 1009464003932 catalytic residue [active] 1009464003933 gamma-glutamyl kinase; Provisional; Region: PRK05429 1009464003934 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1009464003935 nucleotide binding site [chemical binding]; other site 1009464003936 homotetrameric interface [polypeptide binding]; other site 1009464003937 putative phosphate binding site [ion binding]; other site 1009464003938 putative allosteric binding site; other site 1009464003939 PUA domain; Region: PUA; pfam01472 1009464003940 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1009464003941 GTP1/OBG; Region: GTP1_OBG; pfam01018 1009464003942 Obg GTPase; Region: Obg; cd01898 1009464003943 G1 box; other site 1009464003944 GTP/Mg2+ binding site [chemical binding]; other site 1009464003945 Switch I region; other site 1009464003946 G2 box; other site 1009464003947 G3 box; other site 1009464003948 Switch II region; other site 1009464003949 G4 box; other site 1009464003950 G5 box; other site 1009464003951 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1009464003952 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1009464003953 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1009464003954 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1009464003955 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1009464003956 homodimer interface [polypeptide binding]; other site 1009464003957 oligonucleotide binding site [chemical binding]; other site 1009464003958 Predicted permeases [General function prediction only]; Region: COG0679 1009464003959 KilA-N domain; Region: KilA-N; pfam04383 1009464003960 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 1009464003961 putative active site [active] 1009464003962 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1009464003963 dimer interface [polypeptide binding]; other site 1009464003964 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1009464003965 nudix motif; other site 1009464003966 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 1009464003967 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1009464003968 homoserine dehydrogenase; Provisional; Region: PRK06349 1009464003969 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1009464003970 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1009464003971 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1009464003972 CAAX protease self-immunity; Region: Abi; pfam02517 1009464003973 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1009464003974 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1009464003975 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1009464003976 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1009464003977 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1009464003978 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1009464003979 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1009464003980 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1009464003981 putative acyl-acceptor binding pocket; other site 1009464003982 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1009464003983 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1009464003984 ABC-ATPase subunit interface; other site 1009464003985 dimer interface [polypeptide binding]; other site 1009464003986 putative PBP binding regions; other site 1009464003987 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1009464003988 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 1009464003989 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1009464003990 intersubunit interface [polypeptide binding]; other site 1009464003991 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1009464003992 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1009464003993 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1009464003994 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1009464003995 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 1009464003996 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1009464003997 Isochorismatase family; Region: Isochorismatase; pfam00857 1009464003998 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1009464003999 catalytic triad [active] 1009464004000 conserved cis-peptide bond; other site 1009464004001 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1009464004002 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 1009464004003 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1009464004004 GntP family permease; Region: GntP_permease; pfam02447 1009464004005 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1009464004006 AAA domain; Region: AAA_33; pfam13671 1009464004007 ATP-binding site [chemical binding]; other site 1009464004008 Gluconate-6-phosphate binding site [chemical binding]; other site 1009464004009 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1009464004010 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009464004011 DNA-binding site [nucleotide binding]; DNA binding site 1009464004012 FCD domain; Region: FCD; pfam07729 1009464004013 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1009464004014 Zn2+ binding site [ion binding]; other site 1009464004015 Mg2+ binding site [ion binding]; other site 1009464004016 K+ potassium transporter; Region: K_trans; pfam02705 1009464004017 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1009464004018 active site 1009464004019 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1009464004020 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1009464004021 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1009464004022 Walker A/P-loop; other site 1009464004023 ATP binding site [chemical binding]; other site 1009464004024 Q-loop/lid; other site 1009464004025 ABC transporter signature motif; other site 1009464004026 Walker B; other site 1009464004027 D-loop; other site 1009464004028 H-loop/switch region; other site 1009464004029 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1009464004030 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1009464004031 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009464004032 Walker A/P-loop; other site 1009464004033 ATP binding site [chemical binding]; other site 1009464004034 Q-loop/lid; other site 1009464004035 ABC transporter signature motif; other site 1009464004036 Walker B; other site 1009464004037 D-loop; other site 1009464004038 H-loop/switch region; other site 1009464004039 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1009464004040 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1009464004041 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1009464004042 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1009464004043 Walker A/P-loop; other site 1009464004044 ATP binding site [chemical binding]; other site 1009464004045 Q-loop/lid; other site 1009464004046 ABC transporter signature motif; other site 1009464004047 Walker B; other site 1009464004048 D-loop; other site 1009464004049 H-loop/switch region; other site 1009464004050 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1009464004051 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1009464004052 Walker A/P-loop; other site 1009464004053 ATP binding site [chemical binding]; other site 1009464004054 Q-loop/lid; other site 1009464004055 ABC transporter signature motif; other site 1009464004056 Walker B; other site 1009464004057 D-loop; other site 1009464004058 H-loop/switch region; other site 1009464004059 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1009464004060 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1009464004061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464004062 dimer interface [polypeptide binding]; other site 1009464004063 conserved gate region; other site 1009464004064 putative PBP binding loops; other site 1009464004065 ABC-ATPase subunit interface; other site 1009464004066 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1009464004067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464004068 dimer interface [polypeptide binding]; other site 1009464004069 conserved gate region; other site 1009464004070 putative PBP binding loops; other site 1009464004071 ABC-ATPase subunit interface; other site 1009464004072 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1009464004073 trimer interface [polypeptide binding]; other site 1009464004074 active site 1009464004075 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1009464004076 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1009464004077 active site 1009464004078 HIGH motif; other site 1009464004079 KMSKS motif; other site 1009464004080 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1009464004081 tRNA binding surface [nucleotide binding]; other site 1009464004082 anticodon binding site; other site 1009464004083 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1009464004084 Predicted methyltransferases [General function prediction only]; Region: COG0313 1009464004085 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1009464004086 putative SAM binding site [chemical binding]; other site 1009464004087 putative homodimer interface [polypeptide binding]; other site 1009464004088 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1009464004089 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1009464004090 Cna protein B-type domain; Region: Cna_B; pfam05738 1009464004091 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1009464004092 Peptidase family C69; Region: Peptidase_C69; pfam03577 1009464004093 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1009464004094 substrate binding site [chemical binding]; other site 1009464004095 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1009464004096 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1009464004097 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1009464004098 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1009464004099 TMP-binding site; other site 1009464004100 ATP-binding site [chemical binding]; other site 1009464004101 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1009464004102 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1009464004103 active site 1009464004104 interdomain interaction site; other site 1009464004105 putative metal-binding site [ion binding]; other site 1009464004106 nucleotide binding site [chemical binding]; other site 1009464004107 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1009464004108 domain I; other site 1009464004109 DNA binding groove [nucleotide binding] 1009464004110 phosphate binding site [ion binding]; other site 1009464004111 domain II; other site 1009464004112 domain III; other site 1009464004113 nucleotide binding site [chemical binding]; other site 1009464004114 catalytic site [active] 1009464004115 domain IV; other site 1009464004116 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1009464004117 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1009464004118 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1009464004119 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1009464004120 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1009464004121 Transglycosylase; Region: Transgly; pfam00912 1009464004122 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1009464004123 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1009464004124 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1009464004125 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1009464004126 motif II; other site 1009464004127 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1009464004128 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1009464004129 DNA binding residues [nucleotide binding] 1009464004130 putative dimer interface [polypeptide binding]; other site 1009464004131 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1009464004132 HSP70 interaction site [polypeptide binding]; other site 1009464004133 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1009464004134 substrate binding site [polypeptide binding]; other site 1009464004135 dimer interface [polypeptide binding]; other site 1009464004136 GrpE; Region: GrpE; pfam01025 1009464004137 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1009464004138 dimer interface [polypeptide binding]; other site 1009464004139 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1009464004140 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1009464004141 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1009464004142 nucleotide binding site [chemical binding]; other site 1009464004143 NEF interaction site [polypeptide binding]; other site 1009464004144 SBD interface [polypeptide binding]; other site 1009464004145 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1009464004146 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1009464004147 ATP binding site [chemical binding]; other site 1009464004148 substrate interface [chemical binding]; other site 1009464004149 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1009464004150 ThiS interaction site; other site 1009464004151 putative active site [active] 1009464004152 tetramer interface [polypeptide binding]; other site 1009464004153 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1009464004154 thiS-thiF/thiG interaction site; other site 1009464004155 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1009464004156 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1009464004157 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 1009464004158 putative active site [active] 1009464004159 putative catalytic site [active] 1009464004160 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1009464004161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464004162 dimer interface [polypeptide binding]; other site 1009464004163 conserved gate region; other site 1009464004164 putative PBP binding loops; other site 1009464004165 ABC-ATPase subunit interface; other site 1009464004166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464004167 dimer interface [polypeptide binding]; other site 1009464004168 conserved gate region; other site 1009464004169 putative PBP binding loops; other site 1009464004170 ABC-ATPase subunit interface; other site 1009464004171 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1009464004172 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1009464004173 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1009464004174 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1009464004175 DNA binding site [nucleotide binding] 1009464004176 domain linker motif; other site 1009464004177 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1009464004178 ligand binding site [chemical binding]; other site 1009464004179 dimerization interface [polypeptide binding]; other site 1009464004180 trehalose synthase; Region: treS_nterm; TIGR02456 1009464004181 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_2; cd11348 1009464004182 active site 1009464004183 catalytic site [active] 1009464004184 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1009464004185 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1009464004186 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1009464004187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464004188 dimer interface [polypeptide binding]; other site 1009464004189 conserved gate region; other site 1009464004190 putative PBP binding loops; other site 1009464004191 ABC-ATPase subunit interface; other site 1009464004192 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1009464004193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464004194 dimer interface [polypeptide binding]; other site 1009464004195 conserved gate region; other site 1009464004196 putative PBP binding loops; other site 1009464004197 ABC-ATPase subunit interface; other site 1009464004198 pullulanase, type I; Region: pulA_typeI; TIGR02104 1009464004199 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1009464004200 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1009464004201 Ca binding site [ion binding]; other site 1009464004202 active site 1009464004203 catalytic site [active] 1009464004204 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1009464004205 MULE transposase domain; Region: MULE; pfam10551 1009464004206 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1009464004207 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1009464004208 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1009464004209 binding surface 1009464004210 TPR motif; other site 1009464004211 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1009464004212 hypothetical protein; Provisional; Region: PRK03298 1009464004213 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1009464004214 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1009464004215 FtsX-like permease family; Region: FtsX; pfam02687 1009464004216 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1009464004217 FtsX-like permease family; Region: FtsX; pfam02687 1009464004218 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1009464004219 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1009464004220 Walker A/P-loop; other site 1009464004221 ATP binding site [chemical binding]; other site 1009464004222 Q-loop/lid; other site 1009464004223 ABC transporter signature motif; other site 1009464004224 Walker B; other site 1009464004225 D-loop; other site 1009464004226 H-loop/switch region; other site 1009464004227 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1009464004228 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1009464004229 recombination protein RecR; Reviewed; Region: recR; PRK00076 1009464004230 RecR protein; Region: RecR; pfam02132 1009464004231 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1009464004232 putative active site [active] 1009464004233 putative metal-binding site [ion binding]; other site 1009464004234 tetramer interface [polypeptide binding]; other site 1009464004235 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1009464004236 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009464004237 Walker A motif; other site 1009464004238 ATP binding site [chemical binding]; other site 1009464004239 Walker B motif; other site 1009464004240 arginine finger; other site 1009464004241 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 1009464004242 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1009464004243 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 1009464004244 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1009464004245 ATP binding site [chemical binding]; other site 1009464004246 Walker A motif; other site 1009464004247 hexamer interface [polypeptide binding]; other site 1009464004248 Walker B motif; other site 1009464004249 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1009464004250 AAA domain; Region: AAA_31; pfam13614 1009464004251 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1009464004252 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1009464004253 Cl- selectivity filter; other site 1009464004254 Cl- binding residues [ion binding]; other site 1009464004255 pore gating glutamate residue; other site 1009464004256 dimer interface [polypeptide binding]; other site 1009464004257 H+/Cl- coupling transport residue; other site 1009464004258 CrcB-like protein; Region: CRCB; pfam02537 1009464004259 CrcB-like protein; Region: CRCB; pfam02537 1009464004260 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1009464004261 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1009464004262 GDP-binding site [chemical binding]; other site 1009464004263 ACT binding site; other site 1009464004264 IMP binding site; other site 1009464004265 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1009464004266 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1009464004267 active site 1009464004268 intersubunit interface [polypeptide binding]; other site 1009464004269 zinc binding site [ion binding]; other site 1009464004270 Na+ binding site [ion binding]; other site 1009464004271 Chorismate mutase type II; Region: CM_2; cl00693 1009464004272 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1009464004273 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1009464004274 putative DNA binding site [nucleotide binding]; other site 1009464004275 putative Zn2+ binding site [ion binding]; other site 1009464004276 AsnC family; Region: AsnC_trans_reg; pfam01037 1009464004277 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1009464004278 transcription termination factor Rho; Provisional; Region: PRK12608 1009464004279 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1009464004280 RNA binding site [nucleotide binding]; other site 1009464004281 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1009464004282 Walker A motif; other site 1009464004283 ATP binding site [chemical binding]; other site 1009464004284 Walker B motif; other site 1009464004285 hypothetical protein; Provisional; Region: PRK07208 1009464004286 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1009464004287 UDP-galactopyranose mutase; Region: GLF; pfam03275 1009464004288 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1009464004289 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1009464004290 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1009464004291 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1009464004292 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1009464004293 GatB domain; Region: GatB_Yqey; pfam02637 1009464004294 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1009464004295 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1009464004296 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1009464004297 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 1009464004298 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1009464004299 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1009464004300 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1009464004301 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009464004302 Walker A/P-loop; other site 1009464004303 ATP binding site [chemical binding]; other site 1009464004304 Q-loop/lid; other site 1009464004305 ABC transporter signature motif; other site 1009464004306 Walker B; other site 1009464004307 D-loop; other site 1009464004308 H-loop/switch region; other site 1009464004309 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1009464004310 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1009464004311 RmuC family; Region: RmuC; pfam02646 1009464004312 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009464004313 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1009464004314 Walker A/P-loop; other site 1009464004315 ATP binding site [chemical binding]; other site 1009464004316 Q-loop/lid; other site 1009464004317 ABC transporter signature motif; other site 1009464004318 Walker B; other site 1009464004319 D-loop; other site 1009464004320 H-loop/switch region; other site 1009464004321 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1009464004322 Clp amino terminal domain; Region: Clp_N; pfam02861 1009464004323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009464004324 Walker A motif; other site 1009464004325 ATP binding site [chemical binding]; other site 1009464004326 Walker B motif; other site 1009464004327 arginine finger; other site 1009464004328 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009464004329 Walker A motif; other site 1009464004330 ATP binding site [chemical binding]; other site 1009464004331 Walker B motif; other site 1009464004332 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1009464004333 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1009464004334 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1009464004335 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1009464004336 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1009464004337 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1009464004338 catalytic residue [active] 1009464004339 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1009464004340 active site 1009464004341 HIGH motif; other site 1009464004342 nucleotide binding site [chemical binding]; other site 1009464004343 active site 1009464004344 KMSKS motif; other site 1009464004345 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1009464004346 amphipathic channel; other site 1009464004347 Asn-Pro-Ala signature motifs; other site 1009464004348 polyphosphate kinase; Provisional; Region: PRK05443 1009464004349 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1009464004350 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1009464004351 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1009464004352 putative domain interface [polypeptide binding]; other site 1009464004353 putative active site [active] 1009464004354 catalytic site [active] 1009464004355 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1009464004356 putative active site [active] 1009464004357 catalytic site [active] 1009464004358 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1009464004359 putative active site [active] 1009464004360 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1009464004361 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 1009464004362 cofactor binding site; other site 1009464004363 DNA binding site [nucleotide binding] 1009464004364 substrate interaction site [chemical binding]; other site 1009464004365 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1009464004366 active site 1009464004367 Ap6A binding site [chemical binding]; other site 1009464004368 nudix motif; other site 1009464004369 metal binding site [ion binding]; metal-binding site 1009464004370 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1009464004371 catalytic core [active] 1009464004372 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1009464004373 active site 1009464004374 Putative amidase domain; Region: Amidase_6; pfam12671 1009464004375 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1009464004376 YcfA-like protein; Region: YcfA; pfam07927 1009464004377 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1009464004378 catalytic triad [active] 1009464004379 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1009464004380 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1009464004381 replicative DNA helicase; Region: DnaB; TIGR00665 1009464004382 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1009464004383 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1009464004384 Walker A motif; other site 1009464004385 ATP binding site [chemical binding]; other site 1009464004386 Walker B motif; other site 1009464004387 DNA binding loops [nucleotide binding] 1009464004388 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1009464004389 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1009464004390 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 1009464004391 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 1009464004392 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1009464004393 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1009464004394 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1009464004395 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1009464004396 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1009464004397 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1009464004398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464004399 dimer interface [polypeptide binding]; other site 1009464004400 conserved gate region; other site 1009464004401 putative PBP binding loops; other site 1009464004402 ABC-ATPase subunit interface; other site 1009464004403 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1009464004404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009464004405 dimer interface [polypeptide binding]; other site 1009464004406 conserved gate region; other site 1009464004407 putative PBP binding loops; other site 1009464004408 ABC-ATPase subunit interface; other site 1009464004409 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 1009464004410 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1009464004411 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1009464004412 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1009464004413 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 1009464004414 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 1009464004415 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 1009464004416 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 1009464004417 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 1009464004418 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 1009464004419 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 1009464004420 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1009464004421 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1009464004422 Walker A/P-loop; other site 1009464004423 ATP binding site [chemical binding]; other site 1009464004424 Q-loop/lid; other site 1009464004425 ABC transporter signature motif; other site 1009464004426 Walker B; other site 1009464004427 D-loop; other site 1009464004428 H-loop/switch region; other site 1009464004429 TOBE domain; Region: TOBE_2; pfam08402 1009464004430 Protein kinase domain; Region: Pkinase; pfam00069 1009464004431 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1009464004432 active site 1009464004433 ATP binding site [chemical binding]; other site 1009464004434 substrate binding site [chemical binding]; other site 1009464004435 activation loop (A-loop); other site 1009464004436 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1009464004437 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1009464004438 catalytic residues [active] 1009464004439 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1009464004440 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1009464004441 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1009464004442 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1009464004443 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1009464004444 active site 1009464004445 NTP binding site [chemical binding]; other site 1009464004446 metal binding triad [ion binding]; metal-binding site 1009464004447 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1009464004448 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1009464004449 Zn2+ binding site [ion binding]; other site 1009464004450 Mg2+ binding site [ion binding]; other site 1009464004451 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1009464004452 active site 1009464004453 Ap6A binding site [chemical binding]; other site 1009464004454 nudix motif; other site 1009464004455 metal binding site [ion binding]; metal-binding site 1009464004456 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1009464004457 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1009464004458 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1009464004459 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1009464004460 ParB-like nuclease domain; Region: ParB; smart00470 1009464004461 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1009464004462 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1009464004463 P-loop; other site 1009464004464 Magnesium ion binding site [ion binding]; other site 1009464004465 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1009464004466 Magnesium ion binding site [ion binding]; other site 1009464004467 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1009464004468 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009464004469 S-adenosylmethionine binding site [chemical binding]; other site 1009464004470 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1009464004471 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1009464004472 G-X-X-G motif; other site 1009464004473 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1009464004474 RxxxH motif; other site 1009464004475 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 1009464004476 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1009464004477 Ribonuclease P; Region: Ribonuclease_P; pfam00825 1009464004478 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399