-- dump date 20140619_100931 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1173025000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1173025000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1173025000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173025000004 Walker A motif; other site 1173025000005 ATP binding site [chemical binding]; other site 1173025000006 Walker B motif; other site 1173025000007 arginine finger; other site 1173025000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1173025000009 DnaA box-binding interface [nucleotide binding]; other site 1173025000010 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 1173025000011 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1173025000012 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1173025000013 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1173025000014 chloroplast protein import component, Tic20 family; Region: 3a0901s05TIC20; TIGR00994 1173025000015 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1173025000016 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1173025000017 dimer interface [polypeptide binding]; other site 1173025000018 active site 1173025000019 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1173025000020 folate binding site [chemical binding]; other site 1173025000021 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1173025000022 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1173025000023 Mg++ binding site [ion binding]; other site 1173025000024 putative catalytic motif [active] 1173025000025 substrate binding site [chemical binding]; other site 1173025000026 competence damage-inducible protein A; Provisional; Region: PRK00549 1173025000027 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1173025000028 putative MPT binding site; other site 1173025000029 Competence-damaged protein; Region: CinA; pfam02464 1173025000030 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1173025000031 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1173025000032 trimer interface [polypeptide binding]; other site 1173025000033 active site 1173025000034 dimer interface [polypeptide binding]; other site 1173025000035 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 1173025000036 active site 1173025000037 dinuclear metal binding site [ion binding]; other site 1173025000038 dimerization interface [polypeptide binding]; other site 1173025000039 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 1173025000040 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173025000041 Coenzyme A binding pocket [chemical binding]; other site 1173025000042 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1173025000043 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1173025000044 active site 1173025000045 (T/H)XGH motif; other site 1173025000046 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1173025000047 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 1173025000048 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 1173025000049 Predicted transcriptional regulator [Transcription]; Region: COG2345 1173025000050 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173025000051 putative Zn2+ binding site [ion binding]; other site 1173025000052 putative DNA binding site [nucleotide binding]; other site 1173025000053 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 1173025000054 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1173025000055 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1173025000056 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1173025000057 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 1173025000058 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1173025000059 putative active site [active] 1173025000060 putative dimer interface [polypeptide binding]; other site 1173025000061 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1173025000062 macrophage migration inhibition factor-like protein; Provisional; Region: PTZ00397 1173025000063 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1173025000064 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1173025000065 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173025000066 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173025000067 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1173025000068 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1173025000069 active site 1173025000070 SAM binding site [chemical binding]; other site 1173025000071 homodimer interface [polypeptide binding]; other site 1173025000072 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1173025000073 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1173025000074 Cytochrome P450; Region: p450; pfam00067 1173025000075 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 1173025000076 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1173025000077 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1173025000078 TPP-binding site [chemical binding]; other site 1173025000079 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 1173025000080 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1173025000081 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1173025000082 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1173025000083 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1173025000084 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025000085 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025000086 binding surface 1173025000087 TPR motif; other site 1173025000088 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1173025000089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173025000090 dimer interface [polypeptide binding]; other site 1173025000091 conserved gate region; other site 1173025000092 ABC-ATPase subunit interface; other site 1173025000093 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 1173025000094 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1173025000095 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1173025000096 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1173025000097 Walker A/P-loop; other site 1173025000098 ATP binding site [chemical binding]; other site 1173025000099 Q-loop/lid; other site 1173025000100 ABC transporter signature motif; other site 1173025000101 Walker B; other site 1173025000102 D-loop; other site 1173025000103 H-loop/switch region; other site 1173025000104 TOBE-like domain; Region: TOBE_3; pfam12857 1173025000105 Haemolytic domain; Region: Haemolytic; cl00506 1173025000106 geranylgeranyl reductase; Region: ChlP; TIGR02028 1173025000107 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1173025000108 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1173025000109 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 1173025000110 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173025000111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173025000112 S-adenosylmethionine binding site [chemical binding]; other site 1173025000113 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1173025000114 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645 1173025000115 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1173025000116 NADH dehydrogenase subunit 4L; Region: ndhE; CHL00015 1173025000117 NADH dehydrogenase subunit 6; Region: ndhG; CHL00016 1173025000118 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1173025000119 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 1173025000120 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1173025000121 NADH dehydrogenase subunit 1; Region: ndhA; CHL00032 1173025000122 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1173025000123 citrate synthase; Provisional; Region: PRK14036 1173025000124 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_1; cd06112 1173025000125 dimer interface [polypeptide binding]; other site 1173025000126 active site 1173025000127 citrylCoA binding site [chemical binding]; other site 1173025000128 oxalacetate/citrate binding site [chemical binding]; other site 1173025000129 coenzyme A binding site [chemical binding]; other site 1173025000130 catalytic triad [active] 1173025000131 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1173025000132 catalytic core [active] 1173025000133 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1173025000134 DHH family; Region: DHH; pfam01368 1173025000135 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1173025000136 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1173025000137 active site 1173025000138 alanine racemase; Reviewed; Region: alr; PRK00053 1173025000139 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1173025000140 active site 1173025000141 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1173025000142 dimer interface [polypeptide binding]; other site 1173025000143 substrate binding site [chemical binding]; other site 1173025000144 catalytic residues [active] 1173025000145 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1173025000146 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1173025000147 putative ADP-binding pocket [chemical binding]; other site 1173025000148 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1173025000149 active site 1173025000150 nucleophile elbow; other site 1173025000151 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1173025000152 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346 1173025000153 putative ligand binding site [chemical binding]; other site 1173025000154 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1173025000155 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1173025000156 NlpC/P60 family; Region: NLPC_P60; pfam00877 1173025000157 dephospho-CoA kinase; Region: TIGR00152 1173025000158 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1173025000159 CoA-binding site [chemical binding]; other site 1173025000160 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1173025000161 active site 1173025000162 SAM binding site [chemical binding]; other site 1173025000163 homodimer interface [polypeptide binding]; other site 1173025000164 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1173025000165 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1173025000166 active site 1173025000167 RDD family; Region: RDD; pfam06271 1173025000168 tocopherol phytyltransferase; Reviewed; Region: ubiA; PRK12887 1173025000169 UbiA prenyltransferase family; Region: UbiA; pfam01040 1173025000170 tocopherol O-methyltransferase; Region: PLN02244 1173025000171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173025000172 S-adenosylmethionine binding site [chemical binding]; other site 1173025000173 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173025000174 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173025000175 S-adenosylmethionine binding site [chemical binding]; other site 1173025000176 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1173025000177 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1173025000178 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1173025000179 TrkA-N domain; Region: TrkA_N; pfam02254 1173025000180 TrkA-C domain; Region: TrkA_C; pfam02080 1173025000181 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1173025000182 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1173025000183 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1173025000184 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1173025000185 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1173025000186 MgtC family; Region: MgtC; pfam02308 1173025000187 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1173025000188 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1173025000189 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 1173025000190 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1173025000191 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1173025000192 generic binding surface II; other site 1173025000193 generic binding surface I; other site 1173025000194 recombinase A; Provisional; Region: recA; PRK09354 1173025000195 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1173025000196 hexamer interface [polypeptide binding]; other site 1173025000197 Walker A motif; other site 1173025000198 ATP binding site [chemical binding]; other site 1173025000199 Walker B motif; other site 1173025000200 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173025000201 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173025000202 phosphopeptide binding site; other site 1173025000203 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173025000204 Domain of unknown function (DUF1815); Region: DUF1815; pfam08844 1173025000205 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 1173025000206 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025000207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025000208 active site 1173025000209 phosphorylation site [posttranslational modification] 1173025000210 intermolecular recognition site; other site 1173025000211 dimerization interface [polypeptide binding]; other site 1173025000212 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025000213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025000214 ATP binding site [chemical binding]; other site 1173025000215 Mg2+ binding site [ion binding]; other site 1173025000216 G-X-G motif; other site 1173025000217 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025000218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025000219 active site 1173025000220 phosphorylation site [posttranslational modification] 1173025000221 intermolecular recognition site; other site 1173025000222 dimerization interface [polypeptide binding]; other site 1173025000223 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173025000224 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173025000225 metal binding site [ion binding]; metal-binding site 1173025000226 active site 1173025000227 I-site; other site 1173025000228 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1173025000229 GAF domain; Region: GAF; pfam01590 1173025000230 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025000231 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025000232 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025000233 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025000234 dimer interface [polypeptide binding]; other site 1173025000235 phosphorylation site [posttranslational modification] 1173025000236 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025000237 ATP binding site [chemical binding]; other site 1173025000238 Mg2+ binding site [ion binding]; other site 1173025000239 G-X-G motif; other site 1173025000240 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025000241 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025000242 active site 1173025000243 phosphorylation site [posttranslational modification] 1173025000244 intermolecular recognition site; other site 1173025000245 dimerization interface [polypeptide binding]; other site 1173025000246 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173025000247 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 1173025000248 Probable transposase; Region: OrfB_IS605; pfam01385 1173025000249 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173025000250 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173025000251 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173025000252 structural tetrad; other site 1173025000253 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173025000254 structural tetrad; other site 1173025000255 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173025000256 WD domain, G-beta repeat; Region: WD40; pfam00400 1173025000257 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1173025000258 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1173025000259 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173025000260 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025000261 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025000262 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025000263 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025000264 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025000265 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173025000266 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025000267 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025000268 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025000269 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025000270 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025000271 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025000272 arogenate dehydrogenase; Reviewed; Region: PRK07417 1173025000273 prephenate dehydrogenase; Validated; Region: PRK08507 1173025000274 HPP family; Region: HPP; pfam04982 1173025000275 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1173025000276 PhoH-like protein; Region: PhoH; pfam02562 1173025000277 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 1173025000278 active site 1173025000279 putative lithium-binding site [ion binding]; other site 1173025000280 substrate binding site [chemical binding]; other site 1173025000281 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1173025000282 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173025000283 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1173025000284 Probable transposase; Region: OrfB_IS605; pfam01385 1173025000285 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1173025000286 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1173025000287 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1173025000288 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1173025000289 aspartate kinase; Provisional; Region: PRK07431 1173025000290 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1173025000291 putative nucleotide binding site [chemical binding]; other site 1173025000292 putative catalytic residues [active] 1173025000293 putative Mg ion binding site [ion binding]; other site 1173025000294 putative aspartate binding site [chemical binding]; other site 1173025000295 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1173025000296 putative allosteric regulatory site; other site 1173025000297 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1173025000298 putative allosteric regulatory residue; other site 1173025000299 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1173025000300 putative allosteric regulatory site; other site 1173025000301 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1173025000302 putative allosteric regulatory residue; other site 1173025000303 Thf1-like protein; Reviewed; Region: PRK13266 1173025000304 photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060 1173025000305 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 1173025000306 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 1173025000307 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1173025000308 tandem repeat interface [polypeptide binding]; other site 1173025000309 oligomer interface [polypeptide binding]; other site 1173025000310 active site residues [active] 1173025000311 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1173025000312 tandem repeat interface [polypeptide binding]; other site 1173025000313 oligomer interface [polypeptide binding]; other site 1173025000314 active site residues [active] 1173025000315 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1173025000316 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1173025000317 homotetramer interface [polypeptide binding]; other site 1173025000318 FMN binding site [chemical binding]; other site 1173025000319 homodimer contacts [polypeptide binding]; other site 1173025000320 putative active site [active] 1173025000321 putative substrate binding site [chemical binding]; other site 1173025000322 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1173025000323 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173025000324 active site 1173025000325 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1173025000326 Rrf2 family protein; Region: rrf2_super; TIGR00738 1173025000327 Transcriptional regulator; Region: Rrf2; cl17282 1173025000328 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 1173025000329 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173025000330 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173025000331 active site 1173025000332 ATP binding site [chemical binding]; other site 1173025000333 substrate binding site [chemical binding]; other site 1173025000334 activation loop (A-loop); other site 1173025000335 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1173025000336 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1173025000337 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 1173025000338 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1173025000339 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173025000340 FeS/SAM binding site; other site 1173025000341 TRAM domain; Region: TRAM; pfam01938 1173025000342 S-layer homology domain; Region: SLH; pfam00395 1173025000343 S-layer homology domain; Region: SLH; pfam00395 1173025000344 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1173025000345 Resolvase, N terminal domain; Region: Resolvase; smart00857 1173025000346 catalytic residues [active] 1173025000347 Recombinase; Region: Recombinase; pfam07508 1173025000348 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1173025000349 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1173025000350 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1173025000351 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1173025000352 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1173025000353 C-terminal peptidase (prc); Region: prc; TIGR00225 1173025000354 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1173025000355 protein binding site [polypeptide binding]; other site 1173025000356 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1173025000357 Catalytic dyad [active] 1173025000358 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1173025000359 FAD binding pocket [chemical binding]; other site 1173025000360 conserved FAD binding motif [chemical binding]; other site 1173025000361 phosphate binding motif [ion binding]; other site 1173025000362 beta-alpha-beta structure motif; other site 1173025000363 NAD binding pocket [chemical binding]; other site 1173025000364 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1173025000365 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1173025000366 Catalytic site [active] 1173025000367 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 1173025000368 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1173025000369 Short C-terminal domain; Region: SHOCT; pfam09851 1173025000370 HEAT repeats; Region: HEAT_2; pfam13646 1173025000371 HEAT repeats; Region: HEAT_2; pfam13646 1173025000372 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1173025000373 HEAT repeats; Region: HEAT_2; pfam13646 1173025000374 FOG: CBS domain [General function prediction only]; Region: COG0517 1173025000375 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 1173025000376 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1173025000377 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1173025000378 M42 glutamyl aminopeptidase; Region: Peptidase_M42; pfam05343 1173025000379 S-layer homology domain; Region: SLH; pfam00395 1173025000380 S-layer homology domain; Region: SLH; pfam00395 1173025000381 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1173025000382 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1173025000383 active site 1173025000384 catalytic site [active] 1173025000385 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 1173025000386 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467 1173025000387 starch-binding site 2 [chemical binding]; other site 1173025000388 starch-binding site 1 [chemical binding]; other site 1173025000389 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173025000390 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173025000391 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1173025000392 anti sigma factor interaction site; other site 1173025000393 regulatory phosphorylation site [posttranslational modification]; other site 1173025000394 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1173025000395 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1173025000396 Domain of unknown function DUF59; Region: DUF59; pfam01883 1173025000397 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1173025000398 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1173025000399 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1173025000400 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 1173025000401 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1173025000402 dinuclear metal binding motif [ion binding]; other site 1173025000403 DNA polymerase I; Provisional; Region: PRK05755 1173025000404 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1173025000405 active site 1173025000406 metal binding site 1 [ion binding]; metal-binding site 1173025000407 putative 5' ssDNA interaction site; other site 1173025000408 metal binding site 3; metal-binding site 1173025000409 metal binding site 2 [ion binding]; metal-binding site 1173025000410 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1173025000411 putative DNA binding site [nucleotide binding]; other site 1173025000412 putative metal binding site [ion binding]; other site 1173025000413 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1173025000414 active site 1173025000415 catalytic site [active] 1173025000416 substrate binding site [chemical binding]; other site 1173025000417 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1173025000418 active site 1173025000419 DNA binding site [nucleotide binding] 1173025000420 catalytic site [active] 1173025000421 Sporulation and spore germination; Region: Germane; pfam10646 1173025000422 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1173025000423 SNF2 Helicase protein; Region: DUF3670; pfam12419 1173025000424 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173025000425 ATP binding site [chemical binding]; other site 1173025000426 putative Mg++ binding site [ion binding]; other site 1173025000427 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173025000428 nucleotide binding region [chemical binding]; other site 1173025000429 ATP-binding site [chemical binding]; other site 1173025000430 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1173025000431 Clp protease ATP binding subunit; Region: clpC; CHL00095 1173025000432 Clp amino terminal domain; Region: Clp_N; pfam02861 1173025000433 Clp amino terminal domain; Region: Clp_N; pfam02861 1173025000434 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173025000435 Walker A motif; other site 1173025000436 ATP binding site [chemical binding]; other site 1173025000437 Walker B motif; other site 1173025000438 arginine finger; other site 1173025000439 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173025000440 Walker A motif; other site 1173025000441 ATP binding site [chemical binding]; other site 1173025000442 Walker B motif; other site 1173025000443 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1173025000444 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1173025000445 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1173025000446 substrate-cofactor binding pocket; other site 1173025000447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173025000448 catalytic residue [active] 1173025000449 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173025000450 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173025000451 S-adenosylmethionine binding site [chemical binding]; other site 1173025000452 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 1173025000453 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173025000454 FeS/SAM binding site; other site 1173025000455 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 1173025000456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173025000457 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1173025000458 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173025000459 motif II; other site 1173025000460 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 1173025000461 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 1173025000462 active site 1173025000463 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354 1173025000464 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 1173025000465 Protein of unknown function, DUF608; Region: DUF608; pfam04685 1173025000466 hypothetical protein; Reviewed; Region: PRK00024 1173025000467 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1173025000468 MPN+ (JAMM) motif; other site 1173025000469 Zinc-binding site [ion binding]; other site 1173025000470 Late competence development protein ComFB; Region: ComFB; pfam10719 1173025000471 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1173025000472 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1173025000473 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1173025000474 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173025000475 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173025000476 DNA binding residues [nucleotide binding] 1173025000477 Putative zinc-finger; Region: zf-HC2; pfam13490 1173025000478 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1173025000479 putative active site pocket [active] 1173025000480 dimerization interface [polypeptide binding]; other site 1173025000481 putative catalytic residue [active] 1173025000482 heat shock protein HtpX; Provisional; Region: PRK03982 1173025000483 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1173025000484 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1173025000485 HIGH motif; other site 1173025000486 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1173025000487 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1173025000488 active site 1173025000489 KMSKS motif; other site 1173025000490 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1173025000491 tRNA binding surface [nucleotide binding]; other site 1173025000492 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1173025000493 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK12485 1173025000494 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1173025000495 sequence-specific DNA binding site [nucleotide binding]; other site 1173025000496 salt bridge; other site 1173025000497 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1173025000498 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1173025000499 active site 1173025000500 metal binding site [ion binding]; metal-binding site 1173025000501 interdomain interaction site; other site 1173025000502 AAA domain; Region: AAA_25; pfam13481 1173025000503 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1173025000504 Walker A motif; other site 1173025000505 ATP binding site [chemical binding]; other site 1173025000506 Walker B motif; other site 1173025000507 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173025000508 putative DNA binding site [nucleotide binding]; other site 1173025000509 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1173025000510 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1173025000511 active site 1173025000512 catalytic residues [active] 1173025000513 DNA binding site [nucleotide binding] 1173025000514 Int/Topo IB signature motif; other site 1173025000515 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1173025000516 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 1173025000517 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1173025000518 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1173025000519 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 1173025000520 hydrolase, alpha/beta fold family protein; Region: PLN02824 1173025000521 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1173025000522 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 1173025000523 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 1173025000524 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1173025000525 dimer interface [polypeptide binding]; other site 1173025000526 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1173025000527 active site 1173025000528 Fe binding site [ion binding]; other site 1173025000529 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1173025000530 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173025000531 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 1173025000532 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173025000533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025000534 active site 1173025000535 phosphorylation site [posttranslational modification] 1173025000536 intermolecular recognition site; other site 1173025000537 dimerization interface [polypeptide binding]; other site 1173025000538 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173025000539 DNA binding site [nucleotide binding] 1173025000540 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1173025000541 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1173025000542 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1173025000543 trimer interface [polypeptide binding]; other site 1173025000544 active site 1173025000545 UDP-GlcNAc binding site [chemical binding]; other site 1173025000546 lipid binding site [chemical binding]; lipid-binding site 1173025000547 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 1173025000548 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173025000549 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1173025000550 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173025000551 DNA binding residues [nucleotide binding] 1173025000552 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1173025000553 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173025000554 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1173025000555 protein binding site [polypeptide binding]; other site 1173025000556 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1173025000557 active site 1173025000558 catalytic residues [active] 1173025000559 metal binding site [ion binding]; metal-binding site 1173025000560 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1173025000561 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 1173025000562 arginine-tRNA ligase; Region: PLN02286 1173025000563 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1173025000564 active site 1173025000565 HIGH motif; other site 1173025000566 KMSK motif region; other site 1173025000567 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1173025000568 tRNA binding surface [nucleotide binding]; other site 1173025000569 anticodon binding site; other site 1173025000570 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428 1173025000571 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1173025000572 dimerization interface [polypeptide binding]; other site 1173025000573 active site 1173025000574 Bacterial SH3 domain; Region: SH3_3; pfam08239 1173025000575 Bacterial SH3 domain; Region: SH3_3; pfam08239 1173025000576 adenylosuccinate lyase; Provisional; Region: PRK07380 1173025000577 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1173025000578 tetramer interface [polypeptide binding]; other site 1173025000579 active site 1173025000580 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 1173025000581 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1173025000582 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1173025000583 catalytic residues [active] 1173025000584 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1173025000585 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1173025000586 active site 1173025000587 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1173025000588 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1173025000589 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1173025000590 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1173025000591 nucleotide binding pocket [chemical binding]; other site 1173025000592 K-X-D-G motif; other site 1173025000593 catalytic site [active] 1173025000594 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1173025000595 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1173025000596 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1173025000597 Dimer interface [polypeptide binding]; other site 1173025000598 Hydrogenase/urease accessory protein [Posttranslational modification, protein turnover, chaperones]; Region: HupE; COG2370 1173025000599 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 1173025000600 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1173025000601 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1173025000602 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1173025000603 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1173025000604 putative active site [active] 1173025000605 catalytic triad [active] 1173025000606 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 1173025000607 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1173025000608 metal binding site 2 [ion binding]; metal-binding site 1173025000609 putative DNA binding helix; other site 1173025000610 metal binding site 1 [ion binding]; metal-binding site 1173025000611 dimer interface [polypeptide binding]; other site 1173025000612 structural Zn2+ binding site [ion binding]; other site 1173025000613 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1173025000614 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1173025000615 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1173025000616 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1173025000617 active site 1173025000618 Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941 1173025000619 Uncharacterized conserved protein [Function unknown]; Region: COG5607 1173025000620 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1173025000621 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1173025000622 putative active site [active] 1173025000623 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1173025000624 Predicted kinase [General function prediction only]; Region: COG0645 1173025000625 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1173025000626 ATP-binding site [chemical binding]; other site 1173025000627 Gluconate-6-phosphate binding site [chemical binding]; other site 1173025000628 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1173025000629 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1173025000630 5S rRNA interface [nucleotide binding]; other site 1173025000631 CTC domain interface [polypeptide binding]; other site 1173025000632 L16 interface [polypeptide binding]; other site 1173025000633 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1173025000634 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1173025000635 GDP-binding site [chemical binding]; other site 1173025000636 ACT binding site; other site 1173025000637 IMP binding site; other site 1173025000638 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1173025000639 Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443 1173025000640 active site 1173025000641 photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044 1173025000642 phosphate transporter ATP-binding protein; Provisional; Region: PRK14243 1173025000643 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1173025000644 Walker A/P-loop; other site 1173025000645 ATP binding site [chemical binding]; other site 1173025000646 Q-loop/lid; other site 1173025000647 ABC transporter signature motif; other site 1173025000648 Walker B; other site 1173025000649 D-loop; other site 1173025000650 H-loop/switch region; other site 1173025000651 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1173025000652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173025000653 dimer interface [polypeptide binding]; other site 1173025000654 conserved gate region; other site 1173025000655 putative PBP binding loops; other site 1173025000656 ABC-ATPase subunit interface; other site 1173025000657 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1173025000658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173025000659 dimer interface [polypeptide binding]; other site 1173025000660 conserved gate region; other site 1173025000661 putative PBP binding loops; other site 1173025000662 ABC-ATPase subunit interface; other site 1173025000663 PBP superfamily domain; Region: PBP_like_2; cl17296 1173025000664 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 1173025000665 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1173025000666 DNA binding site [nucleotide binding] 1173025000667 active site 1173025000668 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1173025000669 Cytochrome c; Region: Cytochrom_C; cl11414 1173025000670 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1173025000671 plastocyanin; Provisional; Region: PRK02710 1173025000672 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 1173025000673 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1173025000674 Subunit I/III interface [polypeptide binding]; other site 1173025000675 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1173025000676 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1173025000677 D-pathway; other site 1173025000678 Putative ubiquinol binding site [chemical binding]; other site 1173025000679 Low-spin heme (heme b) binding site [chemical binding]; other site 1173025000680 Putative water exit pathway; other site 1173025000681 Binuclear center (heme o3/CuB) [ion binding]; other site 1173025000682 K-pathway; other site 1173025000683 Putative proton exit pathway; other site 1173025000684 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1173025000685 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 1173025000686 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1173025000687 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1173025000688 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1173025000689 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1173025000690 UbiA prenyltransferase family; Region: UbiA; pfam01040 1173025000691 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1173025000692 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173025000693 Walker A/P-loop; other site 1173025000694 ATP binding site [chemical binding]; other site 1173025000695 Q-loop/lid; other site 1173025000696 ABC transporter signature motif; other site 1173025000697 Walker B; other site 1173025000698 D-loop; other site 1173025000699 H-loop/switch region; other site 1173025000700 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1173025000701 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1173025000702 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 1173025000703 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1173025000704 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1173025000705 catalytic site [active] 1173025000706 active site 1173025000707 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 1173025000708 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1173025000709 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1173025000710 active site 1173025000711 catalytic site [active] 1173025000712 Trehalase; Region: Trehalase; cl17346 1173025000713 FAD binding domain; Region: FAD_binding_4; pfam01565 1173025000714 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1173025000715 GTP-binding protein required for 40S ribosome biogenesis [Translation, ribosomal structure and biogenesis]; Region: BMS1; COG5192 1173025000716 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 1173025000717 Protein of unknown function, DUF479; Region: DUF479; cl01203 1173025000718 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1173025000719 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1173025000720 FMN binding site [chemical binding]; other site 1173025000721 active site 1173025000722 catalytic residues [active] 1173025000723 substrate binding site [chemical binding]; other site 1173025000724 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 1173025000725 catalytic triad [active] 1173025000726 dimer interface [polypeptide binding]; other site 1173025000727 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1173025000728 Domain of unknown function (DUF4344); Region: DUF4344; pfam14247 1173025000729 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173025000730 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173025000731 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 1173025000732 RDD family; Region: RDD; pfam06271 1173025000733 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1173025000734 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173025000735 NAD(P) binding site [chemical binding]; other site 1173025000736 active site 1173025000737 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1173025000738 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1173025000739 active site 1173025000740 Substrate binding site; other site 1173025000741 Mg++ binding site; other site 1173025000742 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1173025000743 putative trimer interface [polypeptide binding]; other site 1173025000744 putative CoA binding site [chemical binding]; other site 1173025000745 ScpA/B protein; Region: ScpA_ScpB; cl00598 1173025000746 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1173025000747 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1173025000748 Peptidase family M23; Region: Peptidase_M23; pfam01551 1173025000749 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1173025000750 Protein of unknown function DUF58; Region: DUF58; pfam01882 1173025000751 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1173025000752 hydrophobic ligand binding site; other site 1173025000753 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1173025000754 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1173025000755 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 1173025000756 nitrilase; Region: PLN02798 1173025000757 putative active site [active] 1173025000758 catalytic triad [active] 1173025000759 dimer interface [polypeptide binding]; other site 1173025000760 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173025000761 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025000762 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025000763 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025000764 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1173025000765 NADPH bind site [chemical binding]; other site 1173025000766 putative FMN binding site [chemical binding]; other site 1173025000767 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1173025000768 NADPH bind site [chemical binding]; other site 1173025000769 putative FMN binding site [chemical binding]; other site 1173025000770 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1173025000771 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1173025000772 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1173025000773 G1 box; other site 1173025000774 GTP/Mg2+ binding site [chemical binding]; other site 1173025000775 Switch I region; other site 1173025000776 G2 box; other site 1173025000777 Switch II region; other site 1173025000778 G3 box; other site 1173025000779 G4 box; other site 1173025000780 G5 box; other site 1173025000781 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1173025000782 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 1173025000783 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025000784 binding surface 1173025000785 TPR repeat; Region: TPR_11; pfam13414 1173025000786 TPR motif; other site 1173025000787 TPR repeat; Region: TPR_11; pfam13414 1173025000788 TPR repeat; Region: TPR_11; pfam13414 1173025000789 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173025000790 binding surface 1173025000791 TPR motif; other site 1173025000792 TPR repeat; Region: TPR_11; pfam13414 1173025000793 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025000794 binding surface 1173025000795 TPR motif; other site 1173025000796 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1173025000797 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1173025000798 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1173025000799 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1173025000800 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1173025000801 dimer interface [polypeptide binding]; other site 1173025000802 active site 1173025000803 catalytic residue [active] 1173025000804 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1173025000805 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1173025000806 trigger factor; Provisional; Region: tig; PRK01490 1173025000807 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1173025000808 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1173025000809 Clp protease; Region: CLP_protease; pfam00574 1173025000810 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1173025000811 oligomer interface [polypeptide binding]; other site 1173025000812 active site residues [active] 1173025000813 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1173025000814 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1173025000815 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1173025000816 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173025000817 Walker A motif; other site 1173025000818 ATP binding site [chemical binding]; other site 1173025000819 Walker B motif; other site 1173025000820 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1173025000821 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173025000822 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173025000823 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370 1173025000824 dimer interface [polypeptide binding]; other site 1173025000825 FMN binding site [chemical binding]; other site 1173025000826 Predicted transcriptional regulators [Transcription]; Region: COG1725 1173025000827 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1173025000828 DNA-binding site [nucleotide binding]; DNA binding site 1173025000829 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1173025000830 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1173025000831 30S ribosomal protein S1; Reviewed; Region: PRK07400 1173025000832 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1173025000833 RNA binding site [nucleotide binding]; other site 1173025000834 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1173025000835 RNA binding site [nucleotide binding]; other site 1173025000836 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1173025000837 RNA binding site [nucleotide binding]; other site 1173025000838 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 1173025000839 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1173025000840 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1173025000841 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1173025000842 Cl- selectivity filter; other site 1173025000843 Cl- binding residues [ion binding]; other site 1173025000844 pore gating glutamate residue; other site 1173025000845 dimer interface [polypeptide binding]; other site 1173025000846 H+/Cl- coupling transport residue; other site 1173025000847 FOG: CBS domain [General function prediction only]; Region: COG0517 1173025000848 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 1173025000849 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 1173025000850 Ligand Binding Site [chemical binding]; other site 1173025000851 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173025000852 Ligand Binding Site [chemical binding]; other site 1173025000853 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1173025000854 CHASE2 domain; Region: CHASE2; pfam05226 1173025000855 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173025000856 cyclase homology domain; Region: CHD; cd07302 1173025000857 nucleotidyl binding site; other site 1173025000858 metal binding site [ion binding]; metal-binding site 1173025000859 dimer interface [polypeptide binding]; other site 1173025000860 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1173025000861 dimer interface [polypeptide binding]; other site 1173025000862 active site 1173025000863 Schiff base residues; other site 1173025000864 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1173025000865 ribosomal protein L21; Region: rpl21; CHL00075 1173025000866 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1173025000867 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1173025000868 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173025000869 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1173025000870 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173025000871 active site 1173025000872 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 1173025000873 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 1173025000874 substrate binding site; other site 1173025000875 metal-binding site 1173025000876 Oligomer interface; other site 1173025000877 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1173025000878 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1173025000879 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1173025000880 NADP binding site [chemical binding]; other site 1173025000881 active site 1173025000882 putative substrate binding site [chemical binding]; other site 1173025000883 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 1173025000884 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1173025000885 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173025000886 NAD(P) binding site [chemical binding]; other site 1173025000887 active site 1173025000888 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173025000889 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173025000890 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173025000891 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173025000892 active site 1173025000893 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173025000894 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173025000895 NADH dehydrogenase subunit J; Provisional; Region: PRK12494 1173025000896 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1173025000897 NADH dehydrogenase subunit K; Region: ndhK; CHL00023 1173025000898 NADH dehydrogenase subunit 3; Region: ndhC; CHL00022 1173025000899 Rubredoxin [Energy production and conversion]; Region: COG1773 1173025000900 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1173025000901 iron binding site [ion binding]; other site 1173025000902 Ycf48-like protein; Provisional; Region: PRK13684 1173025000903 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 1173025000904 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283 1173025000905 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 1173025000906 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 1173025000907 PsbL protein; Region: PsbL; cl03581 1173025000908 photosystem II reaction center protein J; Provisional; Region: PRK02565 1173025000909 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1173025000910 photosystem I subunit VIII; Validated; Region: psaI; CHL00186 1173025000911 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1173025000912 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1173025000913 dimer interface [polypeptide binding]; other site 1173025000914 motif 1; other site 1173025000915 active site 1173025000916 motif 2; other site 1173025000917 motif 3; other site 1173025000918 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1173025000919 anticodon binding site; other site 1173025000920 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173025000921 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173025000922 DNA binding residues [nucleotide binding] 1173025000923 dimerization interface [polypeptide binding]; other site 1173025000924 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 1173025000925 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1173025000926 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1173025000927 putative substrate binding site [chemical binding]; other site 1173025000928 putative ATP binding site [chemical binding]; other site 1173025000929 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 1173025000930 putative active site [active] 1173025000931 putative metal binding residues [ion binding]; other site 1173025000932 signature motif; other site 1173025000933 putative dimer interface [polypeptide binding]; other site 1173025000934 putative phosphate binding site [ion binding]; other site 1173025000935 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1173025000936 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025000937 binding surface 1173025000938 TPR motif; other site 1173025000939 Tetratricopeptide repeats; Region: TPR; smart00028 1173025000940 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025000941 binding surface 1173025000942 TPR motif; other site 1173025000943 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025000944 binding surface 1173025000945 TPR motif; other site 1173025000946 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173025000947 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025000948 binding surface 1173025000949 TPR repeat; Region: TPR_11; pfam13414 1173025000950 TPR motif; other site 1173025000951 TPR repeat; Region: TPR_11; pfam13414 1173025000952 TPR repeat; Region: TPR_11; pfam13414 1173025000953 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025000954 binding surface 1173025000955 TPR motif; other site 1173025000956 TPR repeat; Region: TPR_11; pfam13414 1173025000957 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025000958 binding surface 1173025000959 TPR motif; other site 1173025000960 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173025000961 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025000962 binding surface 1173025000963 TPR motif; other site 1173025000964 TPR repeat; Region: TPR_11; pfam13414 1173025000965 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025000966 binding surface 1173025000967 TPR motif; other site 1173025000968 TPR repeat; Region: TPR_11; pfam13414 1173025000969 TPR repeat; Region: TPR_11; pfam13414 1173025000970 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025000971 binding surface 1173025000972 TPR motif; other site 1173025000973 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173025000974 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025000975 binding surface 1173025000976 TPR motif; other site 1173025000977 TPR repeat; Region: TPR_11; pfam13414 1173025000978 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025000979 binding surface 1173025000980 TPR motif; other site 1173025000981 TPR repeat; Region: TPR_11; pfam13414 1173025000982 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025000983 Tetratricopeptide repeat; Region: TPR_1; pfam00515 1173025000984 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173025000985 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1173025000986 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173025000987 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173025000988 active site 1173025000989 TPR repeat; Region: TPR_11; pfam13414 1173025000990 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025000991 TPR motif; other site 1173025000992 binding surface 1173025000993 TPR repeat; Region: TPR_11; pfam13414 1173025000994 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1173025000995 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025000996 binding surface 1173025000997 TPR motif; other site 1173025000998 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025000999 binding surface 1173025001000 TPR motif; other site 1173025001001 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025001002 binding surface 1173025001003 TPR motif; other site 1173025001004 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173025001005 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025001006 binding surface 1173025001007 TPR repeat; Region: TPR_11; pfam13414 1173025001008 TPR motif; other site 1173025001009 TPR repeat; Region: TPR_11; pfam13414 1173025001010 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025001011 binding surface 1173025001012 TPR motif; other site 1173025001013 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173025001014 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025001015 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025001016 binding surface 1173025001017 TPR motif; other site 1173025001018 TPR repeat; Region: TPR_11; pfam13414 1173025001019 TPR repeat; Region: TPR_11; pfam13414 1173025001020 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025001021 binding surface 1173025001022 TPR motif; other site 1173025001023 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025001024 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025001025 TPR motif; other site 1173025001026 binding surface 1173025001027 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025001028 binding surface 1173025001029 TPR motif; other site 1173025001030 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173025001031 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025001032 TPR repeat; Region: TPR_11; pfam13414 1173025001033 binding surface 1173025001034 TPR motif; other site 1173025001035 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025001036 binding surface 1173025001037 TPR motif; other site 1173025001038 TPR repeat; Region: TPR_11; pfam13414 1173025001039 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025001040 binding surface 1173025001041 TPR repeat; Region: TPR_11; pfam13414 1173025001042 TPR motif; other site 1173025001043 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173025001044 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173025001045 TPR repeat; Region: TPR_11; pfam13414 1173025001046 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025001047 binding surface 1173025001048 TPR motif; other site 1173025001049 TPR repeat; Region: TPR_11; pfam13414 1173025001050 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025001051 binding surface 1173025001052 TPR motif; other site 1173025001053 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173025001054 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173025001055 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025001056 binding surface 1173025001057 TPR motif; other site 1173025001058 TPR repeat; Region: TPR_11; pfam13414 1173025001059 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025001060 binding surface 1173025001061 TPR motif; other site 1173025001062 TPR repeat; Region: TPR_11; pfam13414 1173025001063 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025001064 binding surface 1173025001065 TPR repeat; Region: TPR_11; pfam13414 1173025001066 TPR motif; other site 1173025001067 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173025001068 TPR repeat; Region: TPR_11; pfam13414 1173025001069 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025001070 binding surface 1173025001071 TPR motif; other site 1173025001072 TPR repeat; Region: TPR_11; pfam13414 1173025001073 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173025001074 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173025001075 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173025001076 Double zinc ribbon; Region: DZR; pfam12773 1173025001077 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1173025001078 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173025001079 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173025001080 phosphopeptide binding site; other site 1173025001081 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173025001082 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1173025001083 Probable transposase; Region: OrfB_IS605; pfam01385 1173025001084 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173025001085 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 1173025001086 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1173025001087 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1173025001088 active site 1173025001089 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173025001090 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173025001091 phosphopeptide binding site; other site 1173025001092 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173025001093 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173025001094 active site 1173025001095 ATP binding site [chemical binding]; other site 1173025001096 substrate binding site [chemical binding]; other site 1173025001097 activation loop (A-loop); other site 1173025001098 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 1173025001099 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1173025001100 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1173025001101 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1173025001102 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1173025001103 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1173025001104 Competence protein; Region: Competence; pfam03772 1173025001105 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1173025001106 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 1173025001107 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1173025001108 dimer interface [polypeptide binding]; other site 1173025001109 motif 1; other site 1173025001110 active site 1173025001111 motif 2; other site 1173025001112 motif 3; other site 1173025001113 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1173025001114 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 1173025001115 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 1173025001116 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 1173025001117 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 1173025001118 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173025001119 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173025001120 active site 1173025001121 ATP binding site [chemical binding]; other site 1173025001122 substrate binding site [chemical binding]; other site 1173025001123 activation loop (A-loop); other site 1173025001124 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173025001125 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173025001126 structural tetrad; other site 1173025001127 DNA polymerase III subunit alpha; Reviewed; Region: PRK07373 1173025001128 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; cl16942 1173025001129 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1173025001130 generic binding surface I; other site 1173025001131 generic binding surface II; other site 1173025001132 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1173025001133 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1173025001134 DNA polymerase III subunit alpha; Reviewed; Region: PRK09532 1173025001135 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1173025001136 active site 1173025001137 PHP Thumb interface [polypeptide binding]; other site 1173025001138 metal binding site [ion binding]; metal-binding site 1173025001139 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1173025001140 protein-splicing catalytic site; other site 1173025001141 thioester formation/cholesterol transfer; other site 1173025001142 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1173025001143 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 1173025001144 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173025001145 FeS/SAM binding site; other site 1173025001146 HemN C-terminal domain; Region: HemN_C; pfam06969 1173025001147 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1173025001148 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1173025001149 putative active site [active] 1173025001150 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1173025001151 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1173025001152 metal ion-dependent adhesion site (MIDAS); other site 1173025001153 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1173025001154 homotrimer interaction site [polypeptide binding]; other site 1173025001155 zinc binding site [ion binding]; other site 1173025001156 CDP-binding sites; other site 1173025001157 16S rRNA methyltransferase B; Provisional; Region: PRK14901 1173025001158 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1173025001159 putative RNA binding site [nucleotide binding]; other site 1173025001160 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173025001161 S-adenosylmethionine binding site [chemical binding]; other site 1173025001162 tellurium resistance terB-like protein; Region: terB_like; cd07177 1173025001163 metal binding site [ion binding]; metal-binding site 1173025001164 Transglycosylase; Region: Transgly; pfam00912 1173025001165 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1173025001166 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1173025001167 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1173025001168 UbiA prenyltransferase family; Region: UbiA; pfam01040 1173025001169 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1173025001170 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1173025001171 P loop; other site 1173025001172 Nucleotide binding site [chemical binding]; other site 1173025001173 DTAP/Switch II; other site 1173025001174 Switch I; other site 1173025001175 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1173025001176 putative dimer interface [polypeptide binding]; other site 1173025001177 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 1173025001178 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1173025001179 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1173025001180 substrate binding site [chemical binding]; other site 1173025001181 glutamase interaction surface [polypeptide binding]; other site 1173025001182 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173025001183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025001184 active site 1173025001185 phosphorylation site [posttranslational modification] 1173025001186 intermolecular recognition site; other site 1173025001187 dimerization interface [polypeptide binding]; other site 1173025001188 GAF domain; Region: GAF_2; pfam13185 1173025001189 GAF domain; Region: GAF; pfam01590 1173025001190 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1173025001191 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173025001192 S-adenosylmethionine binding site [chemical binding]; other site 1173025001193 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1173025001194 GTPase RsgA; Reviewed; Region: PRK12289 1173025001195 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1173025001196 RNA binding site [nucleotide binding]; other site 1173025001197 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1173025001198 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1173025001199 GTP/Mg2+ binding site [chemical binding]; other site 1173025001200 G4 box; other site 1173025001201 G5 box; other site 1173025001202 G1 box; other site 1173025001203 Switch I region; other site 1173025001204 G2 box; other site 1173025001205 G3 box; other site 1173025001206 Switch II region; other site 1173025001207 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1173025001208 CPxP motif; other site 1173025001209 chaperone protein DnaJ; Provisional; Region: PRK14293 1173025001210 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173025001211 HSP70 interaction site [polypeptide binding]; other site 1173025001212 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1173025001213 Zn binding sites [ion binding]; other site 1173025001214 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1173025001215 dimer interface [polypeptide binding]; other site 1173025001216 molecular chaperone DnaK; Provisional; Region: PRK13411 1173025001217 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1173025001218 nucleotide binding site [chemical binding]; other site 1173025001219 NEF interaction site [polypeptide binding]; other site 1173025001220 SBD interface [polypeptide binding]; other site 1173025001221 GrpE; Region: GrpE; pfam01025 1173025001222 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1173025001223 dimer interface [polypeptide binding]; other site 1173025001224 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1173025001225 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1173025001226 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1173025001227 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1173025001228 Walker A motif; other site 1173025001229 ATP binding site [chemical binding]; other site 1173025001230 Walker B motif; other site 1173025001231 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1173025001232 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1173025001233 Walker A motif; other site 1173025001234 ATP binding site [chemical binding]; other site 1173025001235 Walker B motif; other site 1173025001236 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1173025001237 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1173025001238 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1173025001239 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173025001240 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173025001241 active site 1173025001242 ATP binding site [chemical binding]; other site 1173025001243 substrate binding site [chemical binding]; other site 1173025001244 activation loop (A-loop); other site 1173025001245 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1173025001246 NAD(P) binding pocket [chemical binding]; other site 1173025001247 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 1173025001248 Ycf35; Provisional; Region: ycf35; CHL00193 1173025001249 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1173025001250 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 1173025001251 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1173025001252 domain interfaces; other site 1173025001253 active site 1173025001254 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1173025001255 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1173025001256 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1173025001257 DHH family; Region: DHH; pfam01368 1173025001258 DHHA1 domain; Region: DHHA1; pfam02272 1173025001259 DNA topoisomerase III; Validated; Region: PRK08173 1173025001260 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1173025001261 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1173025001262 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1173025001263 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1173025001264 tartrate dehydrogenase; Region: TTC; TIGR02089 1173025001265 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1173025001266 Protein of unknown function (DUF565); Region: DUF565; pfam04483 1173025001267 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1173025001268 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1173025001269 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 1173025001270 putative dimerization interface [polypeptide binding]; other site 1173025001271 CO2 hydration protein (ChpXY); Region: ChpXY; pfam10216 1173025001272 NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473 1173025001273 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173025001274 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 1173025001275 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173025001276 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1173025001277 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 1173025001278 Hexamer interface [polypeptide binding]; other site 1173025001279 Hexagonal pore residue; other site 1173025001280 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1173025001281 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 1173025001282 Hexamer interface [polypeptide binding]; other site 1173025001283 Hexagonal pore residue; other site 1173025001284 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1173025001285 Hexamer/Pentamer interface [polypeptide binding]; other site 1173025001286 central pore; other site 1173025001287 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1173025001288 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 1173025001289 trimer interface [polypeptide binding]; other site 1173025001290 active site 1173025001291 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 1173025001292 putative multimerization interface [polypeptide binding]; other site 1173025001293 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 1173025001294 putative multimerization interface [polypeptide binding]; other site 1173025001295 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 1173025001296 putative multimerization interface [polypeptide binding]; other site 1173025001297 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1173025001298 putative trimer interface [polypeptide binding]; other site 1173025001299 putative CoA binding site [chemical binding]; other site 1173025001300 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1173025001301 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 1173025001302 Hexamer interface [polypeptide binding]; other site 1173025001303 Hexagonal pore residue; other site 1173025001304 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1173025001305 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 1173025001306 Hexamer interface [polypeptide binding]; other site 1173025001307 Hexagonal pore residue; other site 1173025001308 TPR repeat; Region: TPR_11; pfam13414 1173025001309 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025001310 TPR motif; other site 1173025001311 binding surface 1173025001312 TPR repeat; Region: TPR_11; pfam13414 1173025001313 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025001314 binding surface 1173025001315 TPR motif; other site 1173025001316 TPR repeat; Region: TPR_11; pfam13414 1173025001317 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025001318 binding surface 1173025001319 TPR repeat; Region: TPR_11; pfam13414 1173025001320 TPR motif; other site 1173025001321 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 1173025001322 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025001323 TPR repeat; Region: TPR_11; pfam13414 1173025001324 binding surface 1173025001325 TPR motif; other site 1173025001326 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025001327 binding surface 1173025001328 TPR repeat; Region: TPR_11; pfam13414 1173025001329 TPR motif; other site 1173025001330 TPR repeat; Region: TPR_11; pfam13414 1173025001331 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025001332 binding surface 1173025001333 TPR motif; other site 1173025001334 TPR repeat; Region: TPR_11; pfam13414 1173025001335 Tetratricopeptide repeat; Region: TPR_1; pfam00515 1173025001336 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025001337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025001338 active site 1173025001339 phosphorylation site [posttranslational modification] 1173025001340 intermolecular recognition site; other site 1173025001341 dimerization interface [polypeptide binding]; other site 1173025001342 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025001343 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025001344 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025001345 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025001346 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025001347 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1173025001348 dimer interface [polypeptide binding]; other site 1173025001349 phosphorylation site [posttranslational modification] 1173025001350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025001351 ATP binding site [chemical binding]; other site 1173025001352 Mg2+ binding site [ion binding]; other site 1173025001353 G-X-G motif; other site 1173025001354 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025001355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025001356 active site 1173025001357 phosphorylation site [posttranslational modification] 1173025001358 intermolecular recognition site; other site 1173025001359 dimerization interface [polypeptide binding]; other site 1173025001360 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173025001361 cyclase homology domain; Region: CHD; cd07302 1173025001362 nucleotidyl binding site; other site 1173025001363 metal binding site [ion binding]; metal-binding site 1173025001364 dimer interface [polypeptide binding]; other site 1173025001365 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1173025001366 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173025001367 Coenzyme A binding pocket [chemical binding]; other site 1173025001368 histidinol-phosphate aminotransferase; Provisional; Region: PRK02610 1173025001369 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1173025001370 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173025001371 homodimer interface [polypeptide binding]; other site 1173025001372 catalytic residue [active] 1173025001373 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 1173025001374 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173025001375 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1173025001376 dimer interface [polypeptide binding]; other site 1173025001377 RNA polymerase sigma factor; Provisional; Region: PRK12518 1173025001378 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173025001379 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173025001380 DNA binding residues [nucleotide binding] 1173025001381 Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045 1173025001382 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1173025001383 CoA-ligase; Region: Ligase_CoA; pfam00549 1173025001384 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 1173025001385 CoA binding domain; Region: CoA_binding; smart00881 1173025001386 CoA-ligase; Region: Ligase_CoA; pfam00549 1173025001387 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1173025001388 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1173025001389 Walker A/P-loop; other site 1173025001390 ATP binding site [chemical binding]; other site 1173025001391 Q-loop/lid; other site 1173025001392 ABC transporter signature motif; other site 1173025001393 Walker B; other site 1173025001394 D-loop; other site 1173025001395 H-loop/switch region; other site 1173025001396 Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212 1173025001397 Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212 1173025001398 Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212 1173025001399 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1173025001400 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1173025001401 Domain of unknown function (DUF3598); Region: DUF3598; pfam12204 1173025001402 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1173025001403 ribosomal protein S14; Region: rps14; CHL00074 1173025001404 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1173025001405 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1173025001406 minor groove reading motif; other site 1173025001407 helix-hairpin-helix signature motif; other site 1173025001408 substrate binding pocket [chemical binding]; other site 1173025001409 active site 1173025001410 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1173025001411 RIP metalloprotease RseP; Region: TIGR00054 1173025001412 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1173025001413 active site 1173025001414 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1173025001415 protein binding site [polypeptide binding]; other site 1173025001416 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1173025001417 Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184 1173025001418 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173025001419 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 1173025001420 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1173025001421 Aluminium resistance protein; Region: Alum_res; pfam06838 1173025001422 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1173025001423 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1173025001424 Di-iron ligands [ion binding]; other site 1173025001425 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1173025001426 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1173025001427 putative catalytic cysteine [active] 1173025001428 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1173025001429 homopentamer interface [polypeptide binding]; other site 1173025001430 active site 1173025001431 photosystem II reaction center protein Z; Provisional; Region: psbZ; PRK02576 1173025001432 DHH family; Region: DHH; pfam01368 1173025001433 FOG: CBS domain [General function prediction only]; Region: COG0517 1173025001434 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 1173025001435 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 1173025001436 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1173025001437 active site 1173025001438 NTP binding site [chemical binding]; other site 1173025001439 metal binding triad [ion binding]; metal-binding site 1173025001440 Protein kinase domain; Region: Pkinase; pfam00069 1173025001441 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173025001442 active site 1173025001443 ATP binding site [chemical binding]; other site 1173025001444 substrate binding site [chemical binding]; other site 1173025001445 activation loop (A-loop); other site 1173025001446 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1173025001447 MutS domain III; Region: MutS_III; pfam05192 1173025001448 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173025001449 Walker A/P-loop; other site 1173025001450 ATP binding site [chemical binding]; other site 1173025001451 Q-loop/lid; other site 1173025001452 ABC transporter signature motif; other site 1173025001453 Walker B; other site 1173025001454 D-loop; other site 1173025001455 H-loop/switch region; other site 1173025001456 Smr domain; Region: Smr; pfam01713 1173025001457 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 1173025001458 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 1173025001459 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1173025001460 Cytochrome P450; Region: p450; cl12078 1173025001461 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1173025001462 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1173025001463 Nucleoside recognition; Region: Gate; pfam07670 1173025001464 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1173025001465 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 1173025001466 Predicted deacylase [General function prediction only]; Region: COG3608 1173025001467 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 1173025001468 putative active site [active] 1173025001469 Zn binding site [ion binding]; other site 1173025001470 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1173025001471 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1173025001472 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 1173025001473 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 1173025001474 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 1173025001475 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 1173025001476 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1173025001477 classical (c) SDRs; Region: SDR_c; cd05233 1173025001478 NAD(P) binding site [chemical binding]; other site 1173025001479 active site 1173025001480 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1173025001481 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 1173025001482 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1173025001483 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 1173025001484 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 1173025001485 AIR carboxylase; Region: AIRC; smart01001 1173025001486 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 1173025001487 Heme NO binding associated; Region: HNOBA; pfam07701 1173025001488 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1173025001489 cyclase homology domain; Region: CHD; cd07302 1173025001490 nucleotidyl binding site; other site 1173025001491 metal binding site [ion binding]; metal-binding site 1173025001492 dimer interface [polypeptide binding]; other site 1173025001493 PsbP; Region: PsbP; pfam01789 1173025001494 Maf-like protein; Region: Maf; pfam02545 1173025001495 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1173025001496 active site 1173025001497 dimer interface [polypeptide binding]; other site 1173025001498 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173025001499 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173025001500 active site 1173025001501 ATP binding site [chemical binding]; other site 1173025001502 substrate binding site [chemical binding]; other site 1173025001503 activation loop (A-loop); other site 1173025001504 NurA nuclease; Region: NurA; smart00933 1173025001505 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 1173025001506 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1173025001507 P loop; other site 1173025001508 Nucleotide binding site [chemical binding]; other site 1173025001509 DTAP/Switch II; other site 1173025001510 Switch I; other site 1173025001511 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1173025001512 DTAP/Switch II; other site 1173025001513 Switch I; other site 1173025001514 putative phosphoketolase; Provisional; Region: PRK05261 1173025001515 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1173025001516 TPP-binding site; other site 1173025001517 XFP C-terminal domain; Region: XFP_C; pfam09363 1173025001518 transaldolase/EF-hand domain-containing protein; Provisional; Region: PRK12309 1173025001519 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1173025001520 active site 1173025001521 dimer interface [polypeptide binding]; other site 1173025001522 catalytic residue [active] 1173025001523 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 1173025001524 Ca2+ binding site [ion binding]; other site 1173025001525 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173025001526 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173025001527 ligand binding site [chemical binding]; other site 1173025001528 flexible hinge region; other site 1173025001529 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1173025001530 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025001531 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025001532 binding surface 1173025001533 TPR motif; other site 1173025001534 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025001535 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025001536 binding surface 1173025001537 TPR motif; other site 1173025001538 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025001539 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025001540 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173025001541 binding surface 1173025001542 TPR motif; other site 1173025001543 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025001544 binding surface 1173025001545 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025001546 TPR motif; other site 1173025001547 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025001548 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025001549 binding surface 1173025001550 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025001551 TPR motif; other site 1173025001552 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025001553 CHAT domain; Region: CHAT; pfam12770 1173025001554 Caspase domain; Region: Peptidase_C14; pfam00656 1173025001555 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 1173025001556 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1173025001557 amidase catalytic site [active] 1173025001558 Zn binding residues [ion binding]; other site 1173025001559 substrate binding site [chemical binding]; other site 1173025001560 Amidases related to nicotinamidase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PncA; COG1335 1173025001561 catalytic triad [active] 1173025001562 conserved cis-peptide bond; other site 1173025001563 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1173025001564 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 1173025001565 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 1173025001566 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1173025001567 Protein phosphatase 2C; Region: PP2C_2; pfam13672 1173025001568 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1173025001569 nudix motif; other site 1173025001570 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1173025001571 Hemerythrin; Region: Hemerythrin; cd12107 1173025001572 Fe binding site [ion binding]; other site 1173025001573 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1173025001574 HD domain; Region: HD_4; pfam13328 1173025001575 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1173025001576 synthetase active site [active] 1173025001577 NTP binding site [chemical binding]; other site 1173025001578 metal binding site [ion binding]; metal-binding site 1173025001579 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1173025001580 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1173025001581 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 1173025001582 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 1173025001583 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1173025001584 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1173025001585 Walker A/P-loop; other site 1173025001586 ATP binding site [chemical binding]; other site 1173025001587 Q-loop/lid; other site 1173025001588 ABC transporter signature motif; other site 1173025001589 Walker B; other site 1173025001590 D-loop; other site 1173025001591 H-loop/switch region; other site 1173025001592 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1173025001593 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1173025001594 Walker A/P-loop; other site 1173025001595 ATP binding site [chemical binding]; other site 1173025001596 Q-loop/lid; other site 1173025001597 ABC transporter signature motif; other site 1173025001598 Walker B; other site 1173025001599 D-loop; other site 1173025001600 H-loop/switch region; other site 1173025001601 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1173025001602 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1173025001603 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1173025001604 UV radiation resistance protein and autophagy-related subunit 14; Region: Atg14; pfam10186 1173025001605 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 1173025001606 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173025001607 Walker A motif; other site 1173025001608 ATP binding site [chemical binding]; other site 1173025001609 Walker B motif; other site 1173025001610 arginine finger; other site 1173025001611 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173025001612 Walker A motif; other site 1173025001613 ATP binding site [chemical binding]; other site 1173025001614 Walker B motif; other site 1173025001615 arginine finger; other site 1173025001616 Clp protease ATP binding subunit; Region: clpC; CHL00095 1173025001617 Clp amino terminal domain; Region: Clp_N; pfam02861 1173025001618 Clp amino terminal domain; Region: Clp_N; pfam02861 1173025001619 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173025001620 Walker A motif; other site 1173025001621 ATP binding site [chemical binding]; other site 1173025001622 Walker B motif; other site 1173025001623 arginine finger; other site 1173025001624 UvrB/uvrC motif; Region: UVR; pfam02151 1173025001625 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173025001626 Walker A motif; other site 1173025001627 ATP binding site [chemical binding]; other site 1173025001628 Walker B motif; other site 1173025001629 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1173025001630 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1173025001631 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173025001632 Coenzyme A binding pocket [chemical binding]; other site 1173025001633 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1173025001634 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1173025001635 active site 1173025001636 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1173025001637 substrate binding site [chemical binding]; other site 1173025001638 catalytic residues [active] 1173025001639 dimer interface [polypeptide binding]; other site 1173025001640 TIGR00159 family protein; Region: TIGR00159 1173025001641 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1173025001642 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1173025001643 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1173025001644 catalytic residue [active] 1173025001645 putative FPP diphosphate binding site; other site 1173025001646 putative FPP binding hydrophobic cleft; other site 1173025001647 dimer interface [polypeptide binding]; other site 1173025001648 putative IPP diphosphate binding site; other site 1173025001649 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 1173025001650 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173025001651 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 1173025001652 HSP70 interaction site [polypeptide binding]; other site 1173025001653 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1173025001654 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1173025001655 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 1173025001656 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 1173025001657 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173025001658 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1173025001659 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1173025001660 active site 1173025001661 NTP binding site [chemical binding]; other site 1173025001662 metal binding triad [ion binding]; metal-binding site 1173025001663 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1173025001664 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1173025001665 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 1173025001666 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 1173025001667 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 1173025001668 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 1173025001669 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 1173025001670 EamA-like transporter family; Region: EamA; pfam00892 1173025001671 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 1173025001672 Protein of unknown function, DUF482; Region: DUF482; pfam04339 1173025001673 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1173025001674 RibD C-terminal domain; Region: RibD_C; cl17279 1173025001675 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 1173025001676 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173025001677 S-adenosylmethionine binding site [chemical binding]; other site 1173025001678 Cache domain; Region: Cache_1; pfam02743 1173025001679 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025001680 HAMP domain; Region: HAMP; pfam00672 1173025001681 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025001682 dimer interface [polypeptide binding]; other site 1173025001683 phosphorylation site [posttranslational modification] 1173025001684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025001685 ATP binding site [chemical binding]; other site 1173025001686 Mg2+ binding site [ion binding]; other site 1173025001687 G-X-G motif; other site 1173025001688 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1173025001689 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1173025001690 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1173025001691 dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571 1173025001692 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1173025001693 dimerization interface [polypeptide binding]; other site 1173025001694 active site 1173025001695 metal binding site [ion binding]; metal-binding site 1173025001696 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1173025001697 dsRNA binding site [nucleotide binding]; other site 1173025001698 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173025001699 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173025001700 S-adenosylmethionine binding site [chemical binding]; other site 1173025001701 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1173025001702 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 1173025001703 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173025001704 CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918 1173025001705 ligand binding site [chemical binding]; other site 1173025001706 flexible hinge region; other site 1173025001707 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1173025001708 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1173025001709 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1173025001710 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173025001711 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173025001712 ligand binding site [chemical binding]; other site 1173025001713 flexible hinge region; other site 1173025001714 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1173025001715 putative switch regulator; other site 1173025001716 non-specific DNA interactions [nucleotide binding]; other site 1173025001717 DNA binding site [nucleotide binding] 1173025001718 sequence specific DNA binding site [nucleotide binding]; other site 1173025001719 putative cAMP binding site [chemical binding]; other site 1173025001720 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173025001721 Ligand Binding Site [chemical binding]; other site 1173025001722 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 1173025001723 hypothetical protein; Provisional; Region: PRK04447 1173025001724 putative dimer interface [polypeptide binding]; other site 1173025001725 active site pocket [active] 1173025001726 putative cataytic base [active] 1173025001727 CpeS-like protein; Region: CpeS; pfam09367 1173025001728 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1173025001729 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1173025001730 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 1173025001731 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1173025001732 active site 1173025001733 catalytic tetrad [active] 1173025001734 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1173025001735 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1173025001736 Lumazine binding domain; Region: Lum_binding; pfam00677 1173025001737 Lumazine binding domain; Region: Lum_binding; pfam00677 1173025001738 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1173025001739 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1173025001740 Protein of unknown function (DUF721); Region: DUF721; cl02324 1173025001741 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1173025001742 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1173025001743 substrate binding site [chemical binding]; other site 1173025001744 oxyanion hole (OAH) forming residues; other site 1173025001745 trimer interface [polypeptide binding]; other site 1173025001746 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1173025001747 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1173025001748 dimer interface [polypeptide binding]; other site 1173025001749 tetramer interface [polypeptide binding]; other site 1173025001750 PYR/PP interface [polypeptide binding]; other site 1173025001751 TPP binding site [chemical binding]; other site 1173025001752 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1173025001753 TPP-binding site; other site 1173025001754 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1173025001755 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1173025001756 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419 1173025001757 UbiA prenyltransferase family; Region: UbiA; pfam01040 1173025001758 O-succinylbenzoate synthase; Provisional; Region: PRK02714 1173025001759 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1173025001760 active site 1173025001761 O-succinylbenzoic acid--CoA ligase; Reviewed; Region: PRK07445 1173025001762 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1173025001763 acyl-activating enzyme (AAE) consensus motif; other site 1173025001764 putative AMP binding site [chemical binding]; other site 1173025001765 putative active site [active] 1173025001766 putative CoA binding site [chemical binding]; other site 1173025001767 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1173025001768 active site 1173025001769 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173025001770 dimerization interface [polypeptide binding]; other site 1173025001771 putative DNA binding site [nucleotide binding]; other site 1173025001772 putative Zn2+ binding site [ion binding]; other site 1173025001773 Sporulation and spore germination; Region: Germane; pfam10646 1173025001774 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1173025001775 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1173025001776 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1173025001777 dimer interface [polypeptide binding]; other site 1173025001778 motif 1; other site 1173025001779 active site 1173025001780 motif 2; other site 1173025001781 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1173025001782 putative deacylase active site [active] 1173025001783 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1173025001784 active site 1173025001785 motif 3; other site 1173025001786 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1173025001787 anticodon binding site; other site 1173025001788 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1173025001789 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1173025001790 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 1173025001791 trimer interface [polypeptide binding]; other site 1173025001792 active site 1173025001793 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 1173025001794 catalytic site [active] 1173025001795 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025001796 binding surface 1173025001797 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173025001798 TPR motif; other site 1173025001799 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025001800 binding surface 1173025001801 TPR motif; other site 1173025001802 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 1173025001803 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1173025001804 Src homology 2 (SH2) domain; Region: SH2; cl15255 1173025001805 phosphotyrosine binding pocket [polypeptide binding]; other site 1173025001806 hydrophobic binding pocket [polypeptide binding]; other site 1173025001807 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 1173025001808 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025001809 ATP binding site [chemical binding]; other site 1173025001810 Mg2+ binding site [ion binding]; other site 1173025001811 G-X-G motif; other site 1173025001812 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1173025001813 ATP binding site [chemical binding]; other site 1173025001814 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1173025001815 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1173025001816 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173025001817 Walker A/P-loop; other site 1173025001818 ATP binding site [chemical binding]; other site 1173025001819 Q-loop/lid; other site 1173025001820 ABC transporter signature motif; other site 1173025001821 Walker B; other site 1173025001822 D-loop; other site 1173025001823 H-loop/switch region; other site 1173025001824 ABC transporter; Region: ABC_tran_2; pfam12848 1173025001825 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1173025001826 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1173025001827 phosphoglyceromutase; Provisional; Region: PRK05434 1173025001828 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 1173025001829 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 1173025001830 active site 1173025001831 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173025001832 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173025001833 H+ Antiporter protein; Region: 2A0121; TIGR00900 1173025001834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173025001835 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1173025001836 Recombination protein O N terminal; Region: RecO_N; pfam11967 1173025001837 Recombination protein O C terminal; Region: RecO_C; pfam02565 1173025001838 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1173025001839 intersubunit interface [polypeptide binding]; other site 1173025001840 active site 1173025001841 catalytic residue [active] 1173025001842 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1173025001843 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1173025001844 metal binding site [ion binding]; metal-binding site 1173025001845 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1173025001846 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1173025001847 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1173025001848 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1173025001849 ABC-ATPase subunit interface; other site 1173025001850 dimer interface [polypeptide binding]; other site 1173025001851 putative PBP binding regions; other site 1173025001852 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1173025001853 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1173025001854 catalytic triad [active] 1173025001855 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1173025001856 30S subunit binding site; other site 1173025001857 Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321 1173025001858 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1173025001859 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1173025001860 dimer interface [polypeptide binding]; other site 1173025001861 ssDNA binding site [nucleotide binding]; other site 1173025001862 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1173025001863 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1173025001864 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1173025001865 active site 1173025001866 Substrate binding site; other site 1173025001867 Mg++ binding site; other site 1173025001868 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1173025001869 putative CoA binding site [chemical binding]; other site 1173025001870 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1173025001871 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 1173025001872 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 1173025001873 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173025001874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173025001875 S-adenosylmethionine binding site [chemical binding]; other site 1173025001876 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1173025001877 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 1173025001878 YciI-like protein; Reviewed; Region: PRK12864 1173025001879 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1173025001880 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1173025001881 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1173025001882 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1173025001883 Right handed beta helix region; Region: Beta_helix; pfam13229 1173025001884 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1173025001885 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1173025001886 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1173025001887 substrate binding site [chemical binding]; other site 1173025001888 active site 1173025001889 catalytic residues [active] 1173025001890 heterodimer interface [polypeptide binding]; other site 1173025001891 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 1173025001892 NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716 1173025001893 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1173025001894 hypothetical protein; Provisional; Region: PRK04194 1173025001895 Protein of unknown function DUF111; Region: DUF111; cl03398 1173025001896 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1173025001897 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 1173025001898 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173025001899 Walker A/P-loop; other site 1173025001900 ATP binding site [chemical binding]; other site 1173025001901 Q-loop/lid; other site 1173025001902 ABC transporter signature motif; other site 1173025001903 Walker B; other site 1173025001904 D-loop; other site 1173025001905 H-loop/switch region; other site 1173025001906 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1173025001907 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173025001908 active site 1173025001909 motif I; other site 1173025001910 motif II; other site 1173025001911 Peptidase M15; Region: Peptidase_M15_3; cl01194 1173025001912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173025001913 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173025001914 putative substrate translocation pore; other site 1173025001915 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 1173025001916 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1173025001917 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1173025001918 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1173025001919 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 1173025001920 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 1173025001921 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1173025001922 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1173025001923 dimerization interface [polypeptide binding]; other site 1173025001924 DPS ferroxidase diiron center [ion binding]; other site 1173025001925 ion pore; other site 1173025001926 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1173025001927 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173025001928 putative active site [active] 1173025001929 putative metal binding site [ion binding]; other site 1173025001930 mercuric reductase; Validated; Region: PRK06370 1173025001931 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173025001932 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1173025001933 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1173025001934 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1173025001935 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1173025001936 Cupin domain; Region: Cupin_2; pfam07883 1173025001937 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 1173025001938 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 1173025001939 dimer interface [polypeptide binding]; other site 1173025001940 catalytic residue [active] 1173025001941 metal binding site [ion binding]; metal-binding site 1173025001942 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1173025001943 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173025001944 active site 1173025001945 motif I; other site 1173025001946 motif II; other site 1173025001947 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1173025001948 intersubunit interface [polypeptide binding]; other site 1173025001949 active site 1173025001950 Zn2+ binding site [ion binding]; other site 1173025001951 phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816 1173025001952 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025001953 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025001954 dimer interface [polypeptide binding]; other site 1173025001955 phosphorylation site [posttranslational modification] 1173025001956 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025001957 ATP binding site [chemical binding]; other site 1173025001958 Mg2+ binding site [ion binding]; other site 1173025001959 G-X-G motif; other site 1173025001960 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1173025001961 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1173025001962 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1173025001963 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1173025001964 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1173025001965 C-terminal domain interface [polypeptide binding]; other site 1173025001966 GSH binding site (G-site) [chemical binding]; other site 1173025001967 dimer interface [polypeptide binding]; other site 1173025001968 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1173025001969 N-terminal domain interface [polypeptide binding]; other site 1173025001970 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 1173025001971 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1173025001972 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1173025001973 ligand binding site [chemical binding]; other site 1173025001974 NAD binding site [chemical binding]; other site 1173025001975 dimerization interface [polypeptide binding]; other site 1173025001976 catalytic site [active] 1173025001977 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1173025001978 putative L-serine binding site [chemical binding]; other site 1173025001979 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 1173025001980 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1173025001981 RNA binding surface [nucleotide binding]; other site 1173025001982 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1173025001983 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 1173025001984 metal binding site [ion binding]; metal-binding site 1173025001985 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 1173025001986 putative metal binding site [ion binding]; other site 1173025001987 Calx-beta domain; Region: Calx-beta; cl02522 1173025001988 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 1173025001989 putative metal binding site [ion binding]; other site 1173025001990 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 1173025001991 active site 1173025001992 catalytic triad [active] 1173025001993 oxyanion hole [active] 1173025001994 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 1173025001995 putative metal binding site [ion binding]; other site 1173025001996 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 1173025001997 active site 1173025001998 oxyanion hole [active] 1173025001999 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1173025002000 catalytic triad [active] 1173025002001 Sec-independent translocase component C; Provisional; Region: tatC; CHL00182 1173025002002 Protein of unknown function (DUF3067); Region: DUF3067; pfam11267 1173025002003 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 1173025002004 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 1173025002005 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 1173025002006 cytochrome b subunit interaction site [polypeptide binding]; other site 1173025002007 [2Fe-2S] cluster binding site [ion binding]; other site 1173025002008 apocytochrome f; Reviewed; Region: PRK02693 1173025002009 cytochrome f; Region: petA; CHL00037 1173025002010 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1173025002011 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 1173025002012 active site 1173025002013 substrate binding site [chemical binding]; other site 1173025002014 catalytic site [active] 1173025002015 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1173025002016 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025002017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025002018 active site 1173025002019 phosphorylation site [posttranslational modification] 1173025002020 intermolecular recognition site; other site 1173025002021 dimerization interface [polypeptide binding]; other site 1173025002022 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173025002023 DNA binding residues [nucleotide binding] 1173025002024 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173025002025 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173025002026 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1173025002027 Walker A/P-loop; other site 1173025002028 ATP binding site [chemical binding]; other site 1173025002029 Q-loop/lid; other site 1173025002030 ABC transporter signature motif; other site 1173025002031 Walker B; other site 1173025002032 D-loop; other site 1173025002033 H-loop/switch region; other site 1173025002034 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173025002035 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173025002036 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173025002037 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1173025002038 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1173025002039 Ligand Binding Site [chemical binding]; other site 1173025002040 Molecular Tunnel; other site 1173025002041 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 1173025002042 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1173025002043 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1173025002044 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1173025002045 replicative DNA helicase; Region: DnaB; TIGR00665 1173025002046 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1173025002047 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1173025002048 Walker A motif; other site 1173025002049 ATP binding site [chemical binding]; other site 1173025002050 Walker B motif; other site 1173025002051 DNA binding loops [nucleotide binding] 1173025002052 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1173025002053 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1173025002054 Uncharacterized conserved protein [Function unknown]; Region: COG3937 1173025002055 uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792 1173025002056 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173025002057 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1173025002058 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 1173025002059 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1173025002060 NAD binding site [chemical binding]; other site 1173025002061 substrate binding site [chemical binding]; other site 1173025002062 active site 1173025002063 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 1173025002064 Creatinine amidohydrolase; Region: Creatininase; pfam02633 1173025002065 TPR repeat; Region: TPR_11; pfam13414 1173025002066 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025002067 binding surface 1173025002068 TPR motif; other site 1173025002069 TPR repeat; Region: TPR_11; pfam13414 1173025002070 Photosystem I protein M (PsaM); Region: PsaM; pfam07465 1173025002071 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1173025002072 PhoU domain; Region: PhoU; pfam01895 1173025002073 PhoU domain; Region: PhoU; pfam01895 1173025002074 Exoribonuclease R [Transcription]; Region: VacB; COG0557 1173025002075 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1173025002076 RNB domain; Region: RNB; pfam00773 1173025002077 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1173025002078 RNA binding site [nucleotide binding]; other site 1173025002079 aromatic acid decarboxylase; Validated; Region: PRK05920 1173025002080 Flavoprotein; Region: Flavoprotein; pfam02441 1173025002081 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1173025002082 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 1173025002083 magnesium chelatase subunit I; Provisional; Region: bchI; PRK13407 1173025002084 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173025002085 Walker A motif; other site 1173025002086 ATP binding site [chemical binding]; other site 1173025002087 Walker B motif; other site 1173025002088 arginine finger; other site 1173025002089 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1173025002090 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1173025002091 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173025002092 Walker A motif; other site 1173025002093 ATP binding site [chemical binding]; other site 1173025002094 Walker B motif; other site 1173025002095 arginine finger; other site 1173025002096 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1173025002097 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173025002098 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1173025002099 DXD motif; other site 1173025002100 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1173025002101 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173025002102 FeS/SAM binding site; other site 1173025002103 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 1173025002104 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173025002105 DRTGG domain; Region: DRTGG; pfam07085 1173025002106 MAPEG family; Region: MAPEG; cl09190 1173025002107 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1173025002108 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1173025002109 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 1173025002110 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 1173025002111 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1173025002112 B12 binding site [chemical binding]; other site 1173025002113 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173025002114 binding surface 1173025002115 TPR motif; other site 1173025002116 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025002117 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025002118 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025002119 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025002120 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173025002121 binding surface 1173025002122 TPR motif; other site 1173025002123 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025002124 photochlorophyllide reductase subunit L; Region: chlL; CHL00072 1173025002125 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 1173025002126 P-loop; other site 1173025002127 Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979 1173025002128 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 1173025002129 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 1173025002130 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1173025002131 Zn2+ binding site [ion binding]; other site 1173025002132 Mg2+ binding site [ion binding]; other site 1173025002133 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1173025002134 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 1173025002135 L-asparaginase II; Region: Asparaginase_II; cl01842 1173025002136 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1173025002137 G2 box; other site 1173025002138 Switch I region; other site 1173025002139 G3 box; other site 1173025002140 Switch II region; other site 1173025002141 G4 box; other site 1173025002142 Domain of unknown function (DUF697); Region: DUF697; pfam05128 1173025002143 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 1173025002144 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 1173025002145 G1 box; other site 1173025002146 GTP/Mg2+ binding site [chemical binding]; other site 1173025002147 Switch I region; other site 1173025002148 G2 box; other site 1173025002149 Switch II region; other site 1173025002150 G3 box; other site 1173025002151 G4 box; other site 1173025002152 G5 box; other site 1173025002153 Domain of unknown function (DUF697); Region: DUF697; pfam05128 1173025002154 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1173025002155 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1173025002156 RNA binding surface [nucleotide binding]; other site 1173025002157 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1173025002158 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1173025002159 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1173025002160 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 1173025002161 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 1173025002162 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 1173025002163 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 1173025002164 glycogen binding site [chemical binding]; other site 1173025002165 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 1173025002166 active site 1173025002167 catalytic site [active] 1173025002168 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1173025002169 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1173025002170 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1173025002171 interface (dimer of trimers) [polypeptide binding]; other site 1173025002172 Substrate-binding/catalytic site; other site 1173025002173 Zn-binding sites [ion binding]; other site 1173025002174 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173025002175 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1173025002176 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1173025002177 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1173025002178 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1173025002179 catalytic residue [active] 1173025002180 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1173025002181 LabA_like proteins; Region: LabA; cd10911 1173025002182 putative metal binding site [ion binding]; other site 1173025002183 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1173025002184 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1173025002185 active site 1173025002186 HIGH motif; other site 1173025002187 KMSKS motif; other site 1173025002188 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1173025002189 anticodon binding site; other site 1173025002190 tRNA binding surface [nucleotide binding]; other site 1173025002191 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1173025002192 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1173025002193 putative acyl-acceptor binding pocket; other site 1173025002194 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173025002195 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1173025002196 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1173025002197 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1173025002198 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173025002199 Phycobilisome protein; Region: Phycobilisome; cl08227 1173025002200 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173025002201 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025002202 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025002203 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025002204 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025002205 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025002206 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025002207 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173025002208 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025002209 S-layer homology domain; Region: SLH; pfam00395 1173025002210 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 1173025002211 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 1173025002212 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1173025002213 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1173025002214 putative active site [active] 1173025002215 catalytic triad [active] 1173025002216 putative dimer interface [polypeptide binding]; other site 1173025002217 DNA gyrase subunit A; Validated; Region: PRK05560 1173025002218 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1173025002219 CAP-like domain; other site 1173025002220 active site 1173025002221 primary dimer interface [polypeptide binding]; other site 1173025002222 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1173025002223 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1173025002224 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1173025002225 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1173025002226 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1173025002227 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1173025002228 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1173025002229 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1173025002230 hypothetical protein; Validated; Region: PRK00153 1173025002231 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1173025002232 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1173025002233 purine monophosphate binding site [chemical binding]; other site 1173025002234 dimer interface [polypeptide binding]; other site 1173025002235 putative catalytic residues [active] 1173025002236 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1173025002237 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1173025002238 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 1173025002239 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 1173025002240 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1173025002241 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1173025002242 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1173025002243 AMP binding site [chemical binding]; other site 1173025002244 metal binding site [ion binding]; metal-binding site 1173025002245 active site 1173025002246 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1173025002247 putative active site [active] 1173025002248 transaldolase; Provisional; Region: PRK03903 1173025002249 catalytic residue [active] 1173025002250 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1173025002251 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1173025002252 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1173025002253 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1173025002254 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173025002255 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 1173025002256 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1173025002257 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1173025002258 catalytic triad [active] 1173025002259 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1173025002260 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1173025002261 active site 1173025002262 catalytic tetrad [active] 1173025002263 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025002264 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025002265 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173025002266 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025002267 TPR repeat; Region: TPR_11; pfam13414 1173025002268 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025002269 binding surface 1173025002270 TPR motif; other site 1173025002271 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1173025002272 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1173025002273 ring oligomerisation interface [polypeptide binding]; other site 1173025002274 ATP/Mg binding site [chemical binding]; other site 1173025002275 stacking interactions; other site 1173025002276 hinge regions; other site 1173025002277 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1173025002278 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 1173025002279 oligomer interface [polypeptide binding]; other site 1173025002280 metal binding site [ion binding]; metal-binding site 1173025002281 metal binding site [ion binding]; metal-binding site 1173025002282 Cl binding site [ion binding]; other site 1173025002283 aspartate ring; other site 1173025002284 basic sphincter; other site 1173025002285 putative hydrophobic gate; other site 1173025002286 periplasmic entrance; other site 1173025002287 Inositol monophosphatase family; Region: Inositol_P; pfam00459 1173025002288 active site 1173025002289 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173025002290 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173025002291 ligand binding site [chemical binding]; other site 1173025002292 flexible hinge region; other site 1173025002293 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 1173025002294 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 1173025002295 PDZ domain associated with archaeal and bacterial M61 glycyl-aminopeptidases. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to...; Region: PDZ_glycyl_aminopeptidase; cd00990 1173025002296 protein binding site [polypeptide binding]; other site 1173025002297 Protein required for attachment to host cells; Region: Host_attach; cl02398 1173025002298 tellurium resistance terB-like protein; Region: terB_like; cd07177 1173025002299 metal binding site [ion binding]; metal-binding site 1173025002300 quinolinate synthetase; Provisional; Region: PRK09375 1173025002301 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173025002302 Myxococcus xanthus DevT and related proteins, metallophosphatase domain; Region: MPP_DevT; cd07397 1173025002303 putative active site [active] 1173025002304 putative metal binding site [ion binding]; other site 1173025002305 Cupin domain; Region: Cupin_2; cl17218 1173025002306 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1173025002307 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1173025002308 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 1173025002309 Ligand Binding Site [chemical binding]; other site 1173025002310 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173025002311 Ligand Binding Site [chemical binding]; other site 1173025002312 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 1173025002313 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1173025002314 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1173025002315 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1173025002316 NMT1-like family; Region: NMT1_2; pfam13379 1173025002317 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1173025002318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173025002319 dimer interface [polypeptide binding]; other site 1173025002320 conserved gate region; other site 1173025002321 putative PBP binding loops; other site 1173025002322 ABC-ATPase subunit interface; other site 1173025002323 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1173025002324 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 1173025002325 Walker A/P-loop; other site 1173025002326 ATP binding site [chemical binding]; other site 1173025002327 Q-loop/lid; other site 1173025002328 ABC transporter signature motif; other site 1173025002329 Walker B; other site 1173025002330 D-loop; other site 1173025002331 H-loop/switch region; other site 1173025002332 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1173025002333 NMT1-like family; Region: NMT1_2; pfam13379 1173025002334 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1173025002335 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 1173025002336 Walker A/P-loop; other site 1173025002337 ATP binding site [chemical binding]; other site 1173025002338 Q-loop/lid; other site 1173025002339 ABC transporter signature motif; other site 1173025002340 Walker B; other site 1173025002341 D-loop; other site 1173025002342 H-loop/switch region; other site 1173025002343 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 1173025002344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173025002345 putative substrate translocation pore; other site 1173025002346 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173025002347 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 1173025002348 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1173025002349 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1173025002350 [4Fe-4S] binding site [ion binding]; other site 1173025002351 molybdopterin cofactor binding site; other site 1173025002352 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1173025002353 molybdopterin cofactor binding site; other site 1173025002354 Predicted membrane protein [Function unknown]; Region: COG3431 1173025002355 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655 1173025002356 HEAT repeats; Region: HEAT_2; pfam13646 1173025002357 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 1173025002358 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1173025002359 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 1173025002360 Protein of unknown function (DUF2730); Region: DUF2730; pfam10805 1173025002361 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025002362 TPR motif; other site 1173025002363 TPR repeat; Region: TPR_11; pfam13414 1173025002364 binding surface 1173025002365 TPR repeat; Region: TPR_11; pfam13414 1173025002366 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025002367 binding surface 1173025002368 TPR motif; other site 1173025002369 TPR repeat; Region: TPR_11; pfam13414 1173025002370 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025002371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025002372 active site 1173025002373 phosphorylation site [posttranslational modification] 1173025002374 intermolecular recognition site; other site 1173025002375 dimerization interface [polypeptide binding]; other site 1173025002376 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025002377 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025002378 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025002379 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025002380 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025002381 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025002382 dimer interface [polypeptide binding]; other site 1173025002383 phosphorylation site [posttranslational modification] 1173025002384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025002385 ATP binding site [chemical binding]; other site 1173025002386 Mg2+ binding site [ion binding]; other site 1173025002387 G-X-G motif; other site 1173025002388 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025002389 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025002390 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025002391 dimer interface [polypeptide binding]; other site 1173025002392 phosphorylation site [posttranslational modification] 1173025002393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025002394 ATP binding site [chemical binding]; other site 1173025002395 Mg2+ binding site [ion binding]; other site 1173025002396 G-X-G motif; other site 1173025002397 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025002398 active site 1173025002399 phosphorylation site [posttranslational modification] 1173025002400 intermolecular recognition site; other site 1173025002401 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025002402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025002403 active site 1173025002404 phosphorylation site [posttranslational modification] 1173025002405 intermolecular recognition site; other site 1173025002406 dimerization interface [polypeptide binding]; other site 1173025002407 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173025002408 putative binding surface; other site 1173025002409 active site 1173025002410 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1173025002411 NMT1/THI5 like; Region: NMT1; pfam09084 1173025002412 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1173025002413 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1173025002414 Walker A/P-loop; other site 1173025002415 ATP binding site [chemical binding]; other site 1173025002416 Q-loop/lid; other site 1173025002417 ABC transporter signature motif; other site 1173025002418 Walker B; other site 1173025002419 D-loop; other site 1173025002420 H-loop/switch region; other site 1173025002421 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1173025002422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173025002423 dimer interface [polypeptide binding]; other site 1173025002424 conserved gate region; other site 1173025002425 putative PBP binding loops; other site 1173025002426 ABC-ATPase subunit interface; other site 1173025002427 cytosine deaminase-like protein; Validated; Region: PRK07583 1173025002428 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1173025002429 active site 1173025002430 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1173025002431 FAD binding domain; Region: FAD_binding_4; pfam01565 1173025002432 recombination protein RecR; Reviewed; Region: recR; PRK00076 1173025002433 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 1173025002434 DNA binding site [nucleotide binding] 1173025002435 RecR protein; Region: RecR; pfam02132 1173025002436 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1173025002437 putative active site [active] 1173025002438 putative metal-binding site [ion binding]; other site 1173025002439 tetramer interface [polypeptide binding]; other site 1173025002440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025002441 active site 1173025002442 phosphorylation site [posttranslational modification] 1173025002443 intermolecular recognition site; other site 1173025002444 lipoyl synthase; Provisional; Region: PRK12928 1173025002445 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173025002446 FeS/SAM binding site; other site 1173025002447 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1173025002448 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1173025002449 TM-ABC transporter signature motif; other site 1173025002450 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 1173025002451 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1173025002452 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1173025002453 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 1173025002454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173025002455 Walker A motif; other site 1173025002456 ATP binding site [chemical binding]; other site 1173025002457 Walker B motif; other site 1173025002458 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 1173025002459 RxxxH motif; other site 1173025002460 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1173025002461 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 1173025002462 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 1173025002463 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 1173025002464 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1173025002465 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1173025002466 ribosomal protein L23; Region: rpl23; CHL00030 1173025002467 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1173025002468 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1173025002469 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1173025002470 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1173025002471 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1173025002472 putative translocon binding site; other site 1173025002473 protein-rRNA interface [nucleotide binding]; other site 1173025002474 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1173025002475 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1173025002476 G-X-X-G motif; other site 1173025002477 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1173025002478 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1173025002479 23S rRNA interface [nucleotide binding]; other site 1173025002480 5S rRNA interface [nucleotide binding]; other site 1173025002481 putative antibiotic binding site [chemical binding]; other site 1173025002482 L25 interface [polypeptide binding]; other site 1173025002483 L27 interface [polypeptide binding]; other site 1173025002484 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1173025002485 23S rRNA interface [nucleotide binding]; other site 1173025002486 putative translocon interaction site; other site 1173025002487 signal recognition particle (SRP54) interaction site; other site 1173025002488 L23 interface [polypeptide binding]; other site 1173025002489 trigger factor interaction site; other site 1173025002490 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1173025002491 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1173025002492 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1173025002493 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1173025002494 RNA binding site [nucleotide binding]; other site 1173025002495 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1173025002496 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1173025002497 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1173025002498 ribosomal protein S8; Region: rps8; CHL00042 1173025002499 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1173025002500 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1173025002501 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1173025002502 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1173025002503 23S rRNA interface [nucleotide binding]; other site 1173025002504 5S rRNA interface [nucleotide binding]; other site 1173025002505 L27 interface [polypeptide binding]; other site 1173025002506 L5 interface [polypeptide binding]; other site 1173025002507 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1173025002508 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1173025002509 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1173025002510 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1173025002511 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1173025002512 SecY translocase; Region: SecY; pfam00344 1173025002513 adenylate kinase; Provisional; Region: adk; PRK02496 1173025002514 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1173025002515 AMP-binding site [chemical binding]; other site 1173025002516 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1173025002517 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1173025002518 rRNA binding site [nucleotide binding]; other site 1173025002519 predicted 30S ribosome binding site; other site 1173025002520 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1173025002521 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1173025002522 30S ribosomal protein S11; Validated; Region: PRK05309 1173025002523 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1173025002524 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1173025002525 alphaNTD homodimer interface [polypeptide binding]; other site 1173025002526 alphaNTD - beta interaction site [polypeptide binding]; other site 1173025002527 alphaNTD - beta' interaction site [polypeptide binding]; other site 1173025002528 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1173025002529 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1173025002530 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1173025002531 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1173025002532 dimerization interface 3.5A [polypeptide binding]; other site 1173025002533 active site 1173025002534 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1173025002535 23S rRNA interface [nucleotide binding]; other site 1173025002536 L3 interface [polypeptide binding]; other site 1173025002537 ribosomal protein S9; Region: rps9; CHL00079 1173025002538 ribosomal protein L31; Validated; Region: rpl31; CHL00136 1173025002539 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1173025002540 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1173025002541 RF-1 domain; Region: RF-1; pfam00472 1173025002542 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025002543 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173025002544 putative active site [active] 1173025002545 heme pocket [chemical binding]; other site 1173025002546 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025002547 putative active site [active] 1173025002548 heme pocket [chemical binding]; other site 1173025002549 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025002550 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025002551 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025002552 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025002553 dimer interface [polypeptide binding]; other site 1173025002554 phosphorylation site [posttranslational modification] 1173025002555 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025002556 ATP binding site [chemical binding]; other site 1173025002557 Mg2+ binding site [ion binding]; other site 1173025002558 G-X-G motif; other site 1173025002559 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 1173025002560 Stage II sporulation protein; Region: SpoIID; pfam08486 1173025002561 ribonuclease Z; Region: RNase_Z; TIGR02651 1173025002562 GUN4-like; Region: GUN4; pfam05419 1173025002563 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1173025002564 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1173025002565 active site 1173025002566 nucleotide binding site [chemical binding]; other site 1173025002567 HIGH motif; other site 1173025002568 KMSKS motif; other site 1173025002569 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173025002570 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025002571 active site 1173025002572 phosphorylation site [posttranslational modification] 1173025002573 intermolecular recognition site; other site 1173025002574 dimerization interface [polypeptide binding]; other site 1173025002575 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173025002576 DNA binding residues [nucleotide binding] 1173025002577 dimerization interface [polypeptide binding]; other site 1173025002578 isocitrate dehydrogenase; Validated; Region: PRK07362 1173025002579 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1173025002580 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 1173025002581 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173025002582 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1173025002583 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173025002584 DNA binding residues [nucleotide binding] 1173025002585 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; pfam01716 1173025002586 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1173025002587 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025002588 ATP binding site [chemical binding]; other site 1173025002589 Mg2+ binding site [ion binding]; other site 1173025002590 G-X-G motif; other site 1173025002591 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025002592 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025002593 ATP binding site [chemical binding]; other site 1173025002594 Mg2+ binding site [ion binding]; other site 1173025002595 G-X-G motif; other site 1173025002596 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1173025002597 RimM N-terminal domain; Region: RimM; pfam01782 1173025002598 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 1173025002599 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1173025002600 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173025002601 homodimer interface [polypeptide binding]; other site 1173025002602 catalytic residue [active] 1173025002603 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1173025002604 putative homodimer interface [polypeptide binding]; other site 1173025002605 putative active site pocket [active] 1173025002606 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1173025002607 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1173025002608 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1173025002609 Walker A motif; other site 1173025002610 ATP binding site [chemical binding]; other site 1173025002611 Walker B motif; other site 1173025002612 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1173025002613 Protein of unknown function DUF58; Region: DUF58; pfam01882 1173025002614 ferredoxin thioreductase subunit beta; Validated; Region: ftrB; CHL00165 1173025002615 Domain of unknown function (DUF309); Region: DUF309; pfam03745 1173025002616 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1173025002617 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173025002618 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173025002619 structural tetrad; other site 1173025002620 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 1173025002621 MgtE intracellular N domain; Region: MgtE_N; smart00924 1173025002622 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1173025002623 Divalent cation transporter; Region: MgtE; pfam01769 1173025002624 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1173025002625 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1173025002626 dimer interface [polypeptide binding]; other site 1173025002627 anticodon binding site; other site 1173025002628 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1173025002629 homodimer interface [polypeptide binding]; other site 1173025002630 motif 1; other site 1173025002631 active site 1173025002632 motif 2; other site 1173025002633 GAD domain; Region: GAD; pfam02938 1173025002634 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1173025002635 active site 1173025002636 motif 3; other site 1173025002637 cell division protein; Validated; Region: ftsH; CHL00176 1173025002638 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173025002639 Walker A motif; other site 1173025002640 ATP binding site [chemical binding]; other site 1173025002641 Walker B motif; other site 1173025002642 arginine finger; other site 1173025002643 Peptidase family M41; Region: Peptidase_M41; pfam01434 1173025002644 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1173025002645 Mg binding site [ion binding]; other site 1173025002646 nucleotide binding site [chemical binding]; other site 1173025002647 putative protofilament interface [polypeptide binding]; other site 1173025002648 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1173025002649 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1173025002650 HIGH motif; other site 1173025002651 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1173025002652 active site 1173025002653 KMSKS motif; other site 1173025002654 Photosystem II protein Y (PsbY); Region: PsbY; pfam06298 1173025002655 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1173025002656 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1173025002657 trimer interface [polypeptide binding]; other site 1173025002658 putative metal binding site [ion binding]; other site 1173025002659 Protein of unknown function (DUF2396); Region: DUF2396; pfam09654 1173025002660 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173025002661 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1173025002662 active site 1173025002663 metal binding site [ion binding]; metal-binding site 1173025002664 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 1173025002665 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1173025002666 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1173025002667 putative active site [active] 1173025002668 putative metal binding site [ion binding]; other site 1173025002669 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1173025002670 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1173025002671 HflX GTPase family; Region: HflX; cd01878 1173025002672 G1 box; other site 1173025002673 GTP/Mg2+ binding site [chemical binding]; other site 1173025002674 Switch I region; other site 1173025002675 G2 box; other site 1173025002676 G3 box; other site 1173025002677 Switch II region; other site 1173025002678 G4 box; other site 1173025002679 G5 box; other site 1173025002680 TPR repeat; Region: TPR_11; pfam13414 1173025002681 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025002682 binding surface 1173025002683 TPR motif; other site 1173025002684 TPR repeat; Region: TPR_11; pfam13414 1173025002685 Ycf46; Provisional; Region: ycf46; CHL00195 1173025002686 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173025002687 Walker A motif; other site 1173025002688 ATP binding site [chemical binding]; other site 1173025002689 Walker B motif; other site 1173025002690 arginine finger; other site 1173025002691 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 1173025002692 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 1173025002693 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 1173025002694 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1173025002695 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1173025002696 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1173025002697 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1173025002698 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 1173025002699 proposed catalytic triad [active] 1173025002700 active site nucleophile [active] 1173025002701 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1173025002702 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1173025002703 Cl- selectivity filter; other site 1173025002704 Cl- binding residues [ion binding]; other site 1173025002705 pore gating glutamate residue; other site 1173025002706 dimer interface [polypeptide binding]; other site 1173025002707 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1173025002708 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1173025002709 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1173025002710 oligomer interface [polypeptide binding]; other site 1173025002711 active site residues [active] 1173025002712 Clp protease; Region: CLP_protease; pfam00574 1173025002713 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1173025002714 oligomer interface [polypeptide binding]; other site 1173025002715 active site residues [active] 1173025002716 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173025002717 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 1173025002718 HSP70 interaction site [polypeptide binding]; other site 1173025002719 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1173025002720 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 1173025002721 putative active site [active] 1173025002722 Zn binding site [ion binding]; other site 1173025002723 seryl-tRNA synthetase; Provisional; Region: PRK05431 1173025002724 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1173025002725 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1173025002726 dimer interface [polypeptide binding]; other site 1173025002727 active site 1173025002728 motif 1; other site 1173025002729 motif 2; other site 1173025002730 motif 3; other site 1173025002731 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 1173025002732 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1173025002733 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 1173025002734 putative active site [active] 1173025002735 catalytic site [active] 1173025002736 NifU-like domain; Region: NifU; pfam01106 1173025002737 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 1173025002738 PAS fold; Region: PAS_4; pfam08448 1173025002739 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025002740 GAF domain; Region: GAF_3; pfam13492 1173025002741 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025002742 dimer interface [polypeptide binding]; other site 1173025002743 phosphorylation site [posttranslational modification] 1173025002744 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025002745 ATP binding site [chemical binding]; other site 1173025002746 Mg2+ binding site [ion binding]; other site 1173025002747 G-X-G motif; other site 1173025002748 GTP-binding protein LepA; Provisional; Region: PRK05433 1173025002749 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1173025002750 G1 box; other site 1173025002751 putative GEF interaction site [polypeptide binding]; other site 1173025002752 GTP/Mg2+ binding site [chemical binding]; other site 1173025002753 Switch I region; other site 1173025002754 G2 box; other site 1173025002755 G3 box; other site 1173025002756 Switch II region; other site 1173025002757 G4 box; other site 1173025002758 G5 box; other site 1173025002759 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1173025002760 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1173025002761 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1173025002762 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 1173025002763 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1173025002764 NAD binding site [chemical binding]; other site 1173025002765 putative substrate binding site 2 [chemical binding]; other site 1173025002766 putative substrate binding site 1 [chemical binding]; other site 1173025002767 active site 1173025002768 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1173025002769 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1173025002770 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1173025002771 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1173025002772 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1173025002773 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1173025002774 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1173025002775 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1173025002776 Family description; Region: UvrD_C_2; pfam13538 1173025002777 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 1173025002778 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1173025002779 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1173025002780 dimerization interface [polypeptide binding]; other site 1173025002781 active site 1173025002782 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1173025002783 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1173025002784 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 1173025002785 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 1173025002786 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1173025002787 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1173025002788 protein-splicing catalytic site; other site 1173025002789 thioester formation/cholesterol transfer; other site 1173025002790 Hint domain; Region: Hint_2; pfam13403 1173025002791 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 1173025002792 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1173025002793 protein-splicing catalytic site; other site 1173025002794 thioester formation/cholesterol transfer; other site 1173025002795 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1173025002796 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 1173025002797 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766 1173025002798 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1173025002799 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1173025002800 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1173025002801 trimer interface [polypeptide binding]; other site 1173025002802 active site 1173025002803 substrate binding site [chemical binding]; other site 1173025002804 CoA binding site [chemical binding]; other site 1173025002805 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1173025002806 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 1173025002807 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1173025002808 substrate binding pocket [chemical binding]; other site 1173025002809 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1173025002810 B12 binding site [chemical binding]; other site 1173025002811 cobalt ligand [ion binding]; other site 1173025002812 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1173025002813 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1173025002814 Glucose inhibited division protein A; Region: GIDA; pfam01134 1173025002815 EamA-like transporter family; Region: EamA; pfam00892 1173025002816 light-harvesting-like protein 3; Provisional; Region: PLN00014 1173025002817 spermidine synthase; Provisional; Region: PRK03612 1173025002818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173025002819 S-adenosylmethionine binding site [chemical binding]; other site 1173025002820 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1173025002821 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1173025002822 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1173025002823 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1173025002824 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1173025002825 GTP binding site; other site 1173025002826 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1173025002827 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173025002828 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173025002829 metal binding site [ion binding]; metal-binding site 1173025002830 active site 1173025002831 I-site; other site 1173025002832 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1173025002833 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1173025002834 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1173025002835 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364 1173025002836 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1173025002837 hypothetical protein; Validated; Region: PRK00110 1173025002838 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1173025002839 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1173025002840 glucokinase; Provisional; Region: glk; PRK00292 1173025002841 glucokinase, proteobacterial type; Region: glk; TIGR00749 1173025002842 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 1173025002843 protein I interface; other site 1173025002844 D2 interface; other site 1173025002845 protein T interface; other site 1173025002846 chlorophyll binding site; other site 1173025002847 beta carotene binding site; other site 1173025002848 pheophytin binding site; other site 1173025002849 manganese-stabilizing polypeptide interface; other site 1173025002850 CP43 interface; other site 1173025002851 protein L interface; other site 1173025002852 oxygen evolving complex binding site; other site 1173025002853 bromide binding site; other site 1173025002854 quinone binding site; other site 1173025002855 Fe binding site [ion binding]; other site 1173025002856 core light harvesting interface; other site 1173025002857 cytochrome b559 alpha subunit interface; other site 1173025002858 cytochrome c-550 interface; other site 1173025002859 protein J interface; other site 1173025002860 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1173025002861 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025002862 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173025002863 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025002864 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173025002865 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025002866 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1173025002867 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1173025002868 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1173025002869 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1173025002870 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1173025002871 substrate binding pocket [chemical binding]; other site 1173025002872 chain length determination region; other site 1173025002873 substrate-Mg2+ binding site; other site 1173025002874 catalytic residues [active] 1173025002875 aspartate-rich region 1; other site 1173025002876 active site lid residues [active] 1173025002877 aspartate-rich region 2; other site 1173025002878 enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370 1173025002879 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1173025002880 NAD binding site [chemical binding]; other site 1173025002881 homotetramer interface [polypeptide binding]; other site 1173025002882 homodimer interface [polypeptide binding]; other site 1173025002883 substrate binding site [chemical binding]; other site 1173025002884 active site 1173025002885 imidazoleglycerol-phosphate dehydratase; Region: PLN02800 1173025002886 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1173025002887 putative active site pocket [active] 1173025002888 4-fold oligomerization interface [polypeptide binding]; other site 1173025002889 metal binding residues [ion binding]; metal-binding site 1173025002890 3-fold/trimer interface [polypeptide binding]; other site 1173025002891 folate/biopterin transporter; Region: fbt; TIGR00788 1173025002892 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173025002893 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1173025002894 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1173025002895 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173025002896 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173025002897 active site 1173025002898 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952 1173025002899 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1173025002900 dimer interface [polypeptide binding]; other site 1173025002901 active site 1173025002902 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 1173025002903 active site 1173025002904 photosystem I assembly protein Ycf4; Provisional; Region: PRK02542 1173025002905 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 1173025002906 D1 interface; other site 1173025002907 chlorophyll binding site; other site 1173025002908 pheophytin binding site; other site 1173025002909 beta carotene binding site; other site 1173025002910 cytochrome b559 beta interface; other site 1173025002911 quinone binding site; other site 1173025002912 cytochrome b559 alpha interface; other site 1173025002913 protein J interface; other site 1173025002914 protein H interface; other site 1173025002915 protein X interface; other site 1173025002916 core light harvesting protein interface; other site 1173025002917 protein L interface; other site 1173025002918 CP43 interface; other site 1173025002919 protein T interface; other site 1173025002920 Fe binding site [ion binding]; other site 1173025002921 protein M interface; other site 1173025002922 Mn-stabilizing polypeptide interface; other site 1173025002923 bromide binding site; other site 1173025002924 cytochrome c-550 interface; other site 1173025002925 photosystem II 44 kDa protein; Region: psbC; CHL00035 1173025002926 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 1173025002927 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1173025002928 Clp amino terminal domain; Region: Clp_N; pfam02861 1173025002929 Clp amino terminal domain; Region: Clp_N; pfam02861 1173025002930 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173025002931 Walker A motif; other site 1173025002932 ATP binding site [chemical binding]; other site 1173025002933 Walker B motif; other site 1173025002934 arginine finger; other site 1173025002935 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173025002936 Walker A motif; other site 1173025002937 ATP binding site [chemical binding]; other site 1173025002938 Walker B motif; other site 1173025002939 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1173025002940 AMIN domain; Region: AMIN; pfam11741 1173025002941 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1173025002942 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1173025002943 active site 1173025002944 metal binding site [ion binding]; metal-binding site 1173025002945 glutamate racemase; Provisional; Region: PRK00865 1173025002946 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1173025002947 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1173025002948 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1173025002949 active site 1173025002950 dimer interface [polypeptide binding]; other site 1173025002951 motif 1; other site 1173025002952 motif 2; other site 1173025002953 motif 3; other site 1173025002954 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1173025002955 anticodon binding site; other site 1173025002956 Protein of unknown function (DUF2605); Region: DUF2605; pfam10792 1173025002957 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 1173025002958 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1173025002959 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1173025002960 metal binding site [ion binding]; metal-binding site 1173025002961 dimer interface [polypeptide binding]; other site 1173025002962 pyrroline-5-carboxylate reductase; Region: PLN02688 1173025002963 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1173025002964 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1173025002965 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1173025002966 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1173025002967 catalytic residue [active] 1173025002968 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 1173025002969 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1173025002970 anthranilate synthase component I-like protein; Validated; Region: PRK05940 1173025002971 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1173025002972 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1173025002973 Cobalt transport protein; Region: CbiQ; pfam02361 1173025002974 GTP-binding protein Der; Reviewed; Region: PRK00093 1173025002975 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1173025002976 G1 box; other site 1173025002977 GTP/Mg2+ binding site [chemical binding]; other site 1173025002978 Switch I region; other site 1173025002979 G2 box; other site 1173025002980 Switch II region; other site 1173025002981 G3 box; other site 1173025002982 G4 box; other site 1173025002983 G5 box; other site 1173025002984 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1173025002985 G1 box; other site 1173025002986 GTP/Mg2+ binding site [chemical binding]; other site 1173025002987 Switch I region; other site 1173025002988 G2 box; other site 1173025002989 G3 box; other site 1173025002990 Switch II region; other site 1173025002991 G4 box; other site 1173025002992 G5 box; other site 1173025002993 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 1173025002994 Peptidase family M50; Region: Peptidase_M50; pfam02163 1173025002995 active site 1173025002996 putative substrate binding region [chemical binding]; other site 1173025002997 S-layer homology domain; Region: SLH; pfam00395 1173025002998 S-layer homology domain; Region: SLH; pfam00395 1173025002999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1173025003000 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1173025003001 CsbD-like; Region: CsbD; pfam05532 1173025003002 excinuclease ABC subunit B; Provisional; Region: PRK05298 1173025003003 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173025003004 ATP binding site [chemical binding]; other site 1173025003005 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173025003006 nucleotide binding region [chemical binding]; other site 1173025003007 ATP-binding site [chemical binding]; other site 1173025003008 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1173025003009 UvrB/uvrC motif; Region: UVR; pfam02151 1173025003010 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 1173025003011 putative catalytic site [active] 1173025003012 putative metal binding site [ion binding]; other site 1173025003013 putative phosphate binding site [ion binding]; other site 1173025003014 gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371 1173025003015 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 1173025003016 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173025003017 Walker A motif; other site 1173025003018 ATP binding site [chemical binding]; other site 1173025003019 Walker B motif; other site 1173025003020 Gas vesicle protein; Region: Gas_vesicle; pfam00741 1173025003021 Gas vesicle protein K; Region: GvpK; pfam05121 1173025003022 Gas vesicle protein; Region: Gas_vesicle; pfam00741 1173025003023 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1173025003024 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173025003025 S-adenosylmethionine binding site [chemical binding]; other site 1173025003026 Ycf48-like protein; Provisional; Region: PRK13684 1173025003027 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173025003028 active site 1173025003029 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173025003030 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173025003031 active site 1173025003032 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1173025003033 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173025003034 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173025003035 active site 1173025003036 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1173025003037 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 1173025003038 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1173025003039 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173025003040 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173025003041 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1173025003042 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1173025003043 trimer interface [polypeptide binding]; other site 1173025003044 active site 1173025003045 substrate binding site [chemical binding]; other site 1173025003046 CoA binding site [chemical binding]; other site 1173025003047 Uncharacterized conserved protein [Function unknown]; Region: COG3379 1173025003048 Uncharacterized conserved protein [Function unknown]; Region: COG3379 1173025003049 Uncharacterized conserved protein [Function unknown]; Region: COG3379 1173025003050 Uncharacterized conserved protein [Function unknown]; Region: COG3379 1173025003051 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1173025003052 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1173025003053 PAS fold; Region: PAS_4; pfam08448 1173025003054 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025003055 putative active site [active] 1173025003056 heme pocket [chemical binding]; other site 1173025003057 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173025003058 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025003059 GAF domain; Region: GAF; pfam01590 1173025003060 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025003061 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025003062 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025003063 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025003064 dimer interface [polypeptide binding]; other site 1173025003065 phosphorylation site [posttranslational modification] 1173025003066 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025003067 ATP binding site [chemical binding]; other site 1173025003068 Mg2+ binding site [ion binding]; other site 1173025003069 G-X-G motif; other site 1173025003070 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1173025003071 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173025003072 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173025003073 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1173025003074 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1173025003075 putative dimer interface [polypeptide binding]; other site 1173025003076 Cupin domain; Region: Cupin_2; pfam07883 1173025003077 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1173025003078 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1173025003079 active site 1173025003080 substrate-binding site [chemical binding]; other site 1173025003081 metal-binding site [ion binding] 1173025003082 ATP binding site [chemical binding]; other site 1173025003083 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173025003084 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025003085 putative active site [active] 1173025003086 heme pocket [chemical binding]; other site 1173025003087 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025003088 putative active site [active] 1173025003089 heme pocket [chemical binding]; other site 1173025003090 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025003091 dimer interface [polypeptide binding]; other site 1173025003092 phosphorylation site [posttranslational modification] 1173025003093 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025003094 ATP binding site [chemical binding]; other site 1173025003095 Mg2+ binding site [ion binding]; other site 1173025003096 G-X-G motif; other site 1173025003097 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1173025003098 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1173025003099 homodimer interface [polypeptide binding]; other site 1173025003100 Walker A motif; other site 1173025003101 ATP binding site [chemical binding]; other site 1173025003102 hydroxycobalamin binding site [chemical binding]; other site 1173025003103 Walker B motif; other site 1173025003104 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173025003105 AAA domain; Region: AAA_23; pfam13476 1173025003106 Walker A/P-loop; other site 1173025003107 ATP binding site [chemical binding]; other site 1173025003108 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1173025003109 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173025003110 ABC transporter signature motif; other site 1173025003111 Walker B; other site 1173025003112 D-loop; other site 1173025003113 H-loop/switch region; other site 1173025003114 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1173025003115 TAP-like protein; Region: Abhydrolase_4; pfam08386 1173025003116 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1173025003117 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1173025003118 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1173025003119 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173025003120 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1173025003121 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1173025003122 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1173025003123 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1173025003124 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1173025003125 Peptidase family M23; Region: Peptidase_M23; pfam01551 1173025003126 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1173025003127 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1173025003128 catalytic site [active] 1173025003129 putative active site [active] 1173025003130 putative substrate binding site [chemical binding]; other site 1173025003131 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1173025003132 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1173025003133 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1173025003134 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1173025003135 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1173025003136 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173025003137 catalytic residue [active] 1173025003138 translation initiation factor Sui1; Validated; Region: PRK06824 1173025003139 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1173025003140 putative rRNA binding site [nucleotide binding]; other site 1173025003141 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 1173025003142 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173025003143 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1173025003144 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1173025003145 Mg++ binding site [ion binding]; other site 1173025003146 putative catalytic motif [active] 1173025003147 putative substrate binding site [chemical binding]; other site 1173025003148 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 1173025003149 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 1173025003150 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1173025003151 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1173025003152 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173025003153 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025003154 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173025003155 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025003156 Domain of unknown function (DUF202); Region: DUF202; cl09954 1173025003157 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1173025003158 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1173025003159 dimer interface [polypeptide binding]; other site 1173025003160 ssDNA binding site [nucleotide binding]; other site 1173025003161 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1173025003162 rod shape-determining protein MreB; Provisional; Region: PRK13927 1173025003163 MreB and similar proteins; Region: MreB_like; cd10225 1173025003164 nucleotide binding site [chemical binding]; other site 1173025003165 Mg binding site [ion binding]; other site 1173025003166 putative protofilament interaction site [polypeptide binding]; other site 1173025003167 RodZ interaction site [polypeptide binding]; other site 1173025003168 rod shape-determining protein MreC; Provisional; Region: PRK13922 1173025003169 rod shape-determining protein MreC; Region: MreC; pfam04085 1173025003170 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 1173025003171 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1173025003172 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173025003173 motif II; other site 1173025003174 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 1173025003175 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1173025003176 dimerization interface [polypeptide binding]; other site 1173025003177 active site 1173025003178 metal binding site [ion binding]; metal-binding site 1173025003179 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1173025003180 dsRNA binding site [nucleotide binding]; other site 1173025003181 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1173025003182 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173025003183 dimer interface [polypeptide binding]; other site 1173025003184 conserved gate region; other site 1173025003185 ABC-ATPase subunit interface; other site 1173025003186 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1173025003187 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1173025003188 transmembrane helices; other site 1173025003189 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 1173025003190 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1173025003191 heme binding pocket [chemical binding]; other site 1173025003192 heme ligand [chemical binding]; other site 1173025003193 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1173025003194 Fasciclin domain; Region: Fasciclin; pfam02469 1173025003195 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1173025003196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025003197 Mg2+ binding site [ion binding]; other site 1173025003198 G-X-G motif; other site 1173025003199 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1173025003200 anchoring element; other site 1173025003201 dimer interface [polypeptide binding]; other site 1173025003202 ATP binding site [chemical binding]; other site 1173025003203 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1173025003204 active site 1173025003205 putative metal-binding site [ion binding]; other site 1173025003206 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1173025003207 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1173025003208 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1173025003209 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025003210 GAF domain; Region: GAF; pfam01590 1173025003211 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025003212 PAS fold; Region: PAS_3; pfam08447 1173025003213 putative active site [active] 1173025003214 heme pocket [chemical binding]; other site 1173025003215 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173025003216 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025003217 putative active site [active] 1173025003218 heme pocket [chemical binding]; other site 1173025003219 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025003220 putative active site [active] 1173025003221 heme pocket [chemical binding]; other site 1173025003222 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025003223 PAS domain; Region: PAS_9; pfam13426 1173025003224 putative active site [active] 1173025003225 heme pocket [chemical binding]; other site 1173025003226 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025003227 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173025003228 putative active site [active] 1173025003229 heme pocket [chemical binding]; other site 1173025003230 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025003231 putative active site [active] 1173025003232 heme pocket [chemical binding]; other site 1173025003233 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173025003234 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025003235 putative active site [active] 1173025003236 heme pocket [chemical binding]; other site 1173025003237 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025003238 dimer interface [polypeptide binding]; other site 1173025003239 phosphorylation site [posttranslational modification] 1173025003240 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025003241 ATP binding site [chemical binding]; other site 1173025003242 Mg2+ binding site [ion binding]; other site 1173025003243 G-X-G motif; other site 1173025003244 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025003245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025003246 active site 1173025003247 phosphorylation site [posttranslational modification] 1173025003248 intermolecular recognition site; other site 1173025003249 dimerization interface [polypeptide binding]; other site 1173025003250 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1173025003251 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173025003252 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1173025003253 Probable transposase; Region: OrfB_IS605; pfam01385 1173025003254 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173025003255 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1173025003256 active site 1173025003257 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 1173025003258 ribosomal protein L19; Region: rpl19; CHL00084 1173025003259 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1173025003260 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1173025003261 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1173025003262 putative homodimer interface [polypeptide binding]; other site 1173025003263 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1173025003264 heterodimer interface [polypeptide binding]; other site 1173025003265 homodimer interface [polypeptide binding]; other site 1173025003266 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1173025003267 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1173025003268 23S rRNA interface [nucleotide binding]; other site 1173025003269 L7/L12 interface [polypeptide binding]; other site 1173025003270 putative thiostrepton binding site; other site 1173025003271 L25 interface [polypeptide binding]; other site 1173025003272 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1173025003273 mRNA/rRNA interface [nucleotide binding]; other site 1173025003274 ribosomal protein L10 leader as predicted by Rfam (RF00557), score 48.84; GEI7407_R0028; IMG reference gene:2503607015 1173025003275 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1173025003276 23S rRNA interface [nucleotide binding]; other site 1173025003277 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1173025003278 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1173025003279 peripheral dimer interface [polypeptide binding]; other site 1173025003280 core dimer interface [polypeptide binding]; other site 1173025003281 L10 interface [polypeptide binding]; other site 1173025003282 L11 interface [polypeptide binding]; other site 1173025003283 putative EF-Tu interaction site [polypeptide binding]; other site 1173025003284 putative EF-G interaction site [polypeptide binding]; other site 1173025003285 GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450 1173025003286 GIY-YIG motif/motif A; other site 1173025003287 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1173025003288 GSH binding site [chemical binding]; other site 1173025003289 catalytic residues [active] 1173025003290 glutathione synthetase; Provisional; Region: PRK05246 1173025003291 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1173025003292 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1173025003293 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 1173025003294 Peptidase family M50; Region: Peptidase_M50; pfam02163 1173025003295 active site 1173025003296 putative substrate binding region [chemical binding]; other site 1173025003297 FOG: CBS domain [General function prediction only]; Region: COG0517 1173025003298 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1173025003299 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1173025003300 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1173025003301 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1173025003302 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1173025003303 diaminopimelate epimerase; Region: PLN02536 1173025003304 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1173025003305 Sm and related proteins; Region: Sm_like; cl00259 1173025003306 heptamer interface [polypeptide binding]; other site 1173025003307 Sm1 motif; other site 1173025003308 hexamer interface [polypeptide binding]; other site 1173025003309 RNA binding site [nucleotide binding]; other site 1173025003310 Sm2 motif; other site 1173025003311 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1173025003312 putative cation:proton antiport protein; Provisional; Region: PRK10669 1173025003313 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1173025003314 TrkA-N domain; Region: TrkA_N; pfam02254 1173025003315 TrkA-C domain; Region: TrkA_C; pfam02080 1173025003316 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1173025003317 TrkA-C domain; Region: TrkA_C; pfam02080 1173025003318 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; pfam05430 1173025003319 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1173025003320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025003321 active site 1173025003322 phosphorylation site [posttranslational modification] 1173025003323 intermolecular recognition site; other site 1173025003324 dimerization interface [polypeptide binding]; other site 1173025003325 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1173025003326 Zn2+ binding site [ion binding]; other site 1173025003327 Mg2+ binding site [ion binding]; other site 1173025003328 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 1173025003329 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1173025003330 Substrate binding site; other site 1173025003331 Mg++ binding site; other site 1173025003332 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1173025003333 active site 1173025003334 substrate binding site [chemical binding]; other site 1173025003335 CoA binding site [chemical binding]; other site 1173025003336 Taspase1_like domains; Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A...; Region: Taspase1_like; cd04514 1173025003337 active site 1173025003338 dimer interface [polypeptide binding]; other site 1173025003339 catalytic nucleophile [active] 1173025003340 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1173025003341 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1173025003342 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1173025003343 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1173025003344 GTPase CgtA; Reviewed; Region: obgE; PRK12299 1173025003345 GTP1/OBG; Region: GTP1_OBG; pfam01018 1173025003346 Obg GTPase; Region: Obg; cd01898 1173025003347 G1 box; other site 1173025003348 GTP/Mg2+ binding site [chemical binding]; other site 1173025003349 Switch I region; other site 1173025003350 G2 box; other site 1173025003351 G3 box; other site 1173025003352 Switch II region; other site 1173025003353 G4 box; other site 1173025003354 G5 box; other site 1173025003355 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 1173025003356 putative active site [active] 1173025003357 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1173025003358 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1173025003359 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173025003360 catalytic residue [active] 1173025003361 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025003362 PAS domain; Region: PAS_9; pfam13426 1173025003363 putative active site [active] 1173025003364 heme pocket [chemical binding]; other site 1173025003365 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025003366 PAS fold; Region: PAS_3; pfam08447 1173025003367 putative active site [active] 1173025003368 heme pocket [chemical binding]; other site 1173025003369 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025003370 GAF domain; Region: GAF; pfam01590 1173025003371 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025003372 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025003373 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025003374 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025003375 dimer interface [polypeptide binding]; other site 1173025003376 phosphorylation site [posttranslational modification] 1173025003377 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025003378 ATP binding site [chemical binding]; other site 1173025003379 Mg2+ binding site [ion binding]; other site 1173025003380 G-X-G motif; other site 1173025003381 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1173025003382 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 1173025003383 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1173025003384 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1173025003385 pheophorbide a oxygenase; Region: PLN02518 1173025003386 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1173025003387 iron-sulfur cluster [ion binding]; other site 1173025003388 [2Fe-2S] cluster binding site [ion binding]; other site 1173025003389 Pheophorbide a oxygenase; Region: PaO; pfam08417 1173025003390 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1173025003391 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1173025003392 TPP-binding site; other site 1173025003393 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1173025003394 PYR/PP interface [polypeptide binding]; other site 1173025003395 dimer interface [polypeptide binding]; other site 1173025003396 TPP binding site [chemical binding]; other site 1173025003397 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1173025003398 proton extrusion protein PcxA; Provisional; Region: PRK02507 1173025003399 putative acyl transferase; Provisional; Region: PRK10502 1173025003400 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 1173025003401 putative trimer interface [polypeptide binding]; other site 1173025003402 putative active site [active] 1173025003403 putative substrate binding site [chemical binding]; other site 1173025003404 putative CoA binding site [chemical binding]; other site 1173025003405 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173025003406 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1173025003407 putative metal binding site; other site 1173025003408 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173025003409 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173025003410 active site 1173025003411 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173025003412 deoxyhypusine synthase-like protein; Provisional; Region: PRK00770 1173025003413 deoxyhypusine synthase; Region: dhys; TIGR00321 1173025003414 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1173025003415 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1173025003416 Tetramer interface [polypeptide binding]; other site 1173025003417 active site 1173025003418 FMN-binding site [chemical binding]; other site 1173025003419 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 1173025003420 protein I interface; other site 1173025003421 D2 interface; other site 1173025003422 protein T interface; other site 1173025003423 chlorophyll binding site; other site 1173025003424 beta carotene binding site; other site 1173025003425 pheophytin binding site; other site 1173025003426 manganese-stabilizing polypeptide interface; other site 1173025003427 CP43 interface; other site 1173025003428 protein L interface; other site 1173025003429 oxygen evolving complex binding site; other site 1173025003430 bromide binding site; other site 1173025003431 quinone binding site; other site 1173025003432 Fe binding site [ion binding]; other site 1173025003433 core light harvesting interface; other site 1173025003434 cytochrome b559 alpha subunit interface; other site 1173025003435 cytochrome c-550 interface; other site 1173025003436 protein J interface; other site 1173025003437 PAS fold; Region: PAS; pfam00989 1173025003438 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1173025003439 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173025003440 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173025003441 DNA binding residues [nucleotide binding] 1173025003442 FO synthase subunit 1; Reviewed; Region: cofG; PRK06245 1173025003443 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173025003444 FeS/SAM binding site; other site 1173025003445 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1173025003446 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1173025003447 23S rRNA binding site [nucleotide binding]; other site 1173025003448 L21 binding site [polypeptide binding]; other site 1173025003449 L13 binding site [polypeptide binding]; other site 1173025003450 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1173025003451 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1173025003452 substrate binding pocket [chemical binding]; other site 1173025003453 membrane-bound complex binding site; other site 1173025003454 hinge residues; other site 1173025003455 TPR repeat; Region: TPR_11; pfam13414 1173025003456 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025003457 binding surface 1173025003458 TPR motif; other site 1173025003459 TPR repeat; Region: TPR_11; pfam13414 1173025003460 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173025003461 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1173025003462 Probable transposase; Region: OrfB_IS605; pfam01385 1173025003463 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173025003464 pyruvate kinase; Provisional; Region: PRK06354 1173025003465 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1173025003466 domain interfaces; other site 1173025003467 active site 1173025003468 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1173025003469 Circadian oscillating protein COP23; Region: COP23; pfam14218 1173025003470 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1173025003471 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 1173025003472 putative di-iron ligands [ion binding]; other site 1173025003473 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1173025003474 lipoyl attachment site [posttranslational modification]; other site 1173025003475 glycine dehydrogenase; Provisional; Region: PRK05367 1173025003476 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1173025003477 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173025003478 catalytic residue [active] 1173025003479 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1173025003480 tetramer interface [polypeptide binding]; other site 1173025003481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173025003482 catalytic residue [active] 1173025003483 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173025003484 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173025003485 metal binding site [ion binding]; metal-binding site 1173025003486 active site 1173025003487 I-site; other site 1173025003488 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1173025003489 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1173025003490 motif 1; other site 1173025003491 active site 1173025003492 motif 2; other site 1173025003493 motif 3; other site 1173025003494 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1173025003495 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1173025003496 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1173025003497 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1173025003498 EamA-like transporter family; Region: EamA; pfam00892 1173025003499 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173025003500 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173025003501 catalytic loop [active] 1173025003502 iron binding site [ion binding]; other site 1173025003503 Staphylococcal nuclease homologues; Region: SNc; smart00318 1173025003504 Catalytic site; other site 1173025003505 Staphylococcal nuclease homologue; Region: SNase; pfam00565 1173025003506 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1173025003507 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1173025003508 active site 1173025003509 dimerization interface [polypeptide binding]; other site 1173025003510 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173025003511 HSP70 interaction site [polypeptide binding]; other site 1173025003512 TPR repeat; Region: TPR_11; pfam13414 1173025003513 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025003514 binding surface 1173025003515 TPR motif; other site 1173025003516 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 1173025003517 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1173025003518 dimer interface [polypeptide binding]; other site 1173025003519 motif 1; other site 1173025003520 active site 1173025003521 motif 2; other site 1173025003522 motif 3; other site 1173025003523 Ferredoxin [Energy production and conversion]; Region: COG1146 1173025003524 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1173025003525 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1173025003526 Walker A/P-loop; other site 1173025003527 ATP binding site [chemical binding]; other site 1173025003528 Q-loop/lid; other site 1173025003529 ABC transporter signature motif; other site 1173025003530 Walker B; other site 1173025003531 D-loop; other site 1173025003532 H-loop/switch region; other site 1173025003533 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1173025003534 MPN+ (JAMM) motif; other site 1173025003535 Zinc-binding site [ion binding]; other site 1173025003536 hypothetical protein; Validated; Region: PRK07411 1173025003537 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1173025003538 ATP binding site [chemical binding]; other site 1173025003539 substrate interface [chemical binding]; other site 1173025003540 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1173025003541 active site residue [active] 1173025003542 Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751 1173025003543 Ferritin-like domain; Region: Ferritin; pfam00210 1173025003544 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1173025003545 dinuclear metal binding motif [ion binding]; other site 1173025003546 Iron permease FTR1 family; Region: FTR1; cl00475 1173025003547 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1173025003548 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1173025003549 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1173025003550 Protein of unknown function (DUF751); Region: DUF751; pfam05421 1173025003551 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1173025003552 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1173025003553 homotrimer interface [polypeptide binding]; other site 1173025003554 Walker A motif; other site 1173025003555 GTP binding site [chemical binding]; other site 1173025003556 Walker B motif; other site 1173025003557 HEAT repeats; Region: HEAT_2; pfam13646 1173025003558 HEAT repeats; Region: HEAT_2; pfam13646 1173025003559 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1173025003560 HEAT repeats; Region: HEAT_2; pfam13646 1173025003561 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 1173025003562 homotrimer interaction site [polypeptide binding]; other site 1173025003563 active site 1173025003564 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1173025003565 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1173025003566 tandem repeat interface [polypeptide binding]; other site 1173025003567 oligomer interface [polypeptide binding]; other site 1173025003568 active site residues [active] 1173025003569 EamA-like transporter family; Region: EamA; pfam00892 1173025003570 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173025003571 HEAT repeats; Region: HEAT_2; pfam13646 1173025003572 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 1173025003573 protein binding surface [polypeptide binding]; other site 1173025003574 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1173025003575 putative ADP-binding pocket [chemical binding]; other site 1173025003576 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173025003577 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1173025003578 dimer interface [polypeptide binding]; other site 1173025003579 catalytic triad [active] 1173025003580 ChaB; Region: ChaB; pfam06150 1173025003581 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1173025003582 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1173025003583 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 1173025003584 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025003585 dimer interface [polypeptide binding]; other site 1173025003586 phosphorylation site [posttranslational modification] 1173025003587 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025003588 ATP binding site [chemical binding]; other site 1173025003589 Mg2+ binding site [ion binding]; other site 1173025003590 G-X-G motif; other site 1173025003591 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173025003592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025003593 active site 1173025003594 phosphorylation site [posttranslational modification] 1173025003595 intermolecular recognition site; other site 1173025003596 dimerization interface [polypeptide binding]; other site 1173025003597 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173025003598 DNA binding site [nucleotide binding] 1173025003599 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173025003600 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173025003601 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173025003602 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1173025003603 Probable transposase; Region: OrfB_IS605; pfam01385 1173025003604 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173025003605 Putative zinc ribbon domain; Region: DUF164; pfam02591 1173025003606 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173025003607 Ligand Binding Site [chemical binding]; other site 1173025003608 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173025003609 Ligand Binding Site [chemical binding]; other site 1173025003610 photosystem II reaction center protein M; Provisional; Region: psbM; PRK04989 1173025003611 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173025003612 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173025003613 catalytic loop [active] 1173025003614 iron binding site [ion binding]; other site 1173025003615 photosystem II 47 kDa protein; Region: psbB; CHL00062 1173025003616 photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875 1173025003617 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1173025003618 ATP cone domain; Region: ATP-cone; pfam03477 1173025003619 30S ribosomal protein S1; Reviewed; Region: PRK07400 1173025003620 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1173025003621 RNA binding site [nucleotide binding]; other site 1173025003622 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1173025003623 RNA binding site [nucleotide binding]; other site 1173025003624 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1173025003625 RNA binding site [nucleotide binding]; other site 1173025003626 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1173025003627 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173025003628 motif II; other site 1173025003629 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1173025003630 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1173025003631 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1173025003632 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1173025003633 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173025003634 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173025003635 ligand binding site [chemical binding]; other site 1173025003636 flexible hinge region; other site 1173025003637 TLC ATP/ADP transporter; Region: TLC; cl03940 1173025003638 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173025003639 HEAT repeats; Region: HEAT_2; pfam13646 1173025003640 translation initiation factor 3; Provisional; Region: infC; CHL00199 1173025003641 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1173025003642 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1173025003643 hydrolase, alpha/beta fold family protein; Region: PLN02824 1173025003644 acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100 1173025003645 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1173025003646 putative valine binding site [chemical binding]; other site 1173025003647 dimer interface [polypeptide binding]; other site 1173025003648 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1173025003649 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1173025003650 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173025003651 Walker A/P-loop; other site 1173025003652 ATP binding site [chemical binding]; other site 1173025003653 Q-loop/lid; other site 1173025003654 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1173025003655 ABC transporter; Region: ABC_tran_2; pfam12848 1173025003656 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1173025003657 magnesium chelatase subunit H; Provisional; Region: PRK12493 1173025003658 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1173025003659 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1173025003660 Bacterial SH3 domain; Region: SH3_3; cl17532 1173025003661 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173025003662 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025003663 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025003664 GAF domain; Region: GAF; pfam01590 1173025003665 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025003666 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173025003667 putative active site [active] 1173025003668 heme pocket [chemical binding]; other site 1173025003669 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025003670 putative active site [active] 1173025003671 heme pocket [chemical binding]; other site 1173025003672 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173025003673 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173025003674 metal binding site [ion binding]; metal-binding site 1173025003675 active site 1173025003676 I-site; other site 1173025003677 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1173025003678 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1173025003679 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1173025003680 G1 box; other site 1173025003681 putative GEF interaction site [polypeptide binding]; other site 1173025003682 GTP/Mg2+ binding site [chemical binding]; other site 1173025003683 Switch I region; other site 1173025003684 G2 box; other site 1173025003685 G3 box; other site 1173025003686 Switch II region; other site 1173025003687 G4 box; other site 1173025003688 G5 box; other site 1173025003689 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1173025003690 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1173025003691 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 1173025003692 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1173025003693 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1173025003694 active site lid residues [active] 1173025003695 substrate binding pocket [chemical binding]; other site 1173025003696 catalytic residues [active] 1173025003697 substrate-Mg2+ binding site; other site 1173025003698 aspartate-rich region 1; other site 1173025003699 aspartate-rich region 2; other site 1173025003700 phytoene desaturase; Region: phytoene_desat; TIGR02731 1173025003701 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173025003702 molecular chaperone DnaK; Provisional; Region: PRK13410 1173025003703 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1173025003704 nucleotide binding site [chemical binding]; other site 1173025003705 NEF interaction site [polypeptide binding]; other site 1173025003706 SBD interface [polypeptide binding]; other site 1173025003707 chaperone protein DnaJ; Provisional; Region: PRK14299 1173025003708 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173025003709 HSP70 interaction site [polypeptide binding]; other site 1173025003710 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1173025003711 dimer interface [polypeptide binding]; other site 1173025003712 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1173025003713 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1173025003714 trimerization site [polypeptide binding]; other site 1173025003715 active site 1173025003716 Protein of function (DUF2518); Region: DUF2518; pfam10726 1173025003717 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1173025003718 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1173025003719 putative active site [active] 1173025003720 metal binding site [ion binding]; metal-binding site 1173025003721 aspartate aminotransferase; Provisional; Region: PRK05942 1173025003722 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1173025003723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173025003724 homodimer interface [polypeptide binding]; other site 1173025003725 catalytic residue [active] 1173025003726 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173025003727 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173025003728 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 1173025003729 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1173025003730 Zn2+ binding site [ion binding]; other site 1173025003731 Mg2+ binding site [ion binding]; other site 1173025003732 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1173025003733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173025003734 dimer interface [polypeptide binding]; other site 1173025003735 conserved gate region; other site 1173025003736 putative PBP binding loops; other site 1173025003737 ABC-ATPase subunit interface; other site 1173025003738 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1173025003739 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173025003740 S-adenosylmethionine binding site [chemical binding]; other site 1173025003741 Tic22-like family; Region: Tic22; cl04468 1173025003742 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1173025003743 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346 1173025003744 putative ligand binding site [chemical binding]; other site 1173025003745 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 1173025003746 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173025003747 Coenzyme A binding pocket [chemical binding]; other site 1173025003748 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1173025003749 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173025003750 UGMP family protein; Validated; Region: PRK09604 1173025003751 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1173025003752 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 1173025003753 Photosystem I reaction centre subunit IX / PsaJ; Region: PSI_PsaJ; cl03320 1173025003754 photosystem I reaction center protein subunit XI; Provisional; Region: PRK00704 1173025003755 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1173025003756 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1173025003757 catalytic site [active] 1173025003758 G-X2-G-X-G-K; other site 1173025003759 hypothetical protein; Provisional; Region: PRK04323 1173025003760 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1173025003761 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1173025003762 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025003763 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173025003764 dimerization interface [polypeptide binding]; other site 1173025003765 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025003766 dimer interface [polypeptide binding]; other site 1173025003767 phosphorylation site [posttranslational modification] 1173025003768 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025003769 ATP binding site [chemical binding]; other site 1173025003770 Mg2+ binding site [ion binding]; other site 1173025003771 G-X-G motif; other site 1173025003772 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1173025003773 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1173025003774 substrate binding pocket [chemical binding]; other site 1173025003775 membrane-bound complex binding site; other site 1173025003776 S-layer homology domain; Region: SLH; pfam00395 1173025003777 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1173025003778 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1173025003779 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1173025003780 intersubunit interface [polypeptide binding]; other site 1173025003781 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1173025003782 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1173025003783 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1173025003784 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1173025003785 dimer interface [polypeptide binding]; other site 1173025003786 putative PBP binding regions; other site 1173025003787 ABC-ATPase subunit interface; other site 1173025003788 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 1173025003789 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173025003790 putative ADP-binding pocket [chemical binding]; other site 1173025003791 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1173025003792 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1173025003793 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1173025003794 NADP-binding site; other site 1173025003795 homotetramer interface [polypeptide binding]; other site 1173025003796 substrate binding site [chemical binding]; other site 1173025003797 homodimer interface [polypeptide binding]; other site 1173025003798 active site 1173025003799 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1173025003800 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1173025003801 NADP binding site [chemical binding]; other site 1173025003802 active site 1173025003803 putative substrate binding site [chemical binding]; other site 1173025003804 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1173025003805 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1173025003806 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173025003807 ATP binding site [chemical binding]; other site 1173025003808 putative Mg++ binding site [ion binding]; other site 1173025003809 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173025003810 nucleotide binding region [chemical binding]; other site 1173025003811 ATP-binding site [chemical binding]; other site 1173025003812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 1173025003813 conserved hypothetical protein; Region: TIGR03492 1173025003814 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1173025003815 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173025003816 ATP binding site [chemical binding]; other site 1173025003817 putative Mg++ binding site [ion binding]; other site 1173025003818 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173025003819 nucleotide binding region [chemical binding]; other site 1173025003820 ATP-binding site [chemical binding]; other site 1173025003821 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1173025003822 HRDC domain; Region: HRDC; pfam00570 1173025003823 Domain of unknown function (DUF427); Region: DUF427; cl00998 1173025003824 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1173025003825 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1173025003826 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1173025003827 acyl-activating enzyme (AAE) consensus motif; other site 1173025003828 putative AMP binding site [chemical binding]; other site 1173025003829 putative active site [active] 1173025003830 putative CoA binding site [chemical binding]; other site 1173025003831 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 1173025003832 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1173025003833 E3 interaction surface; other site 1173025003834 lipoyl attachment site [posttranslational modification]; other site 1173025003835 e3 binding domain; Region: E3_binding; pfam02817 1173025003836 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 1173025003837 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1173025003838 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1173025003839 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 1173025003840 putative NAD(P) binding site [chemical binding]; other site 1173025003841 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 1173025003842 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 1173025003843 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 1173025003844 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025003845 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173025003846 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025003847 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1173025003848 active site 1173025003849 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1173025003850 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173025003851 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1173025003852 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1173025003853 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1173025003854 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1173025003855 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1173025003856 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1173025003857 hinge; other site 1173025003858 active site 1173025003859 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1173025003860 light-harvesting-like protein 3; Provisional; Region: PLN00014 1173025003861 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1173025003862 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1173025003863 hexamer interface [polypeptide binding]; other site 1173025003864 ligand binding site [chemical binding]; other site 1173025003865 putative active site [active] 1173025003866 NAD(P) binding site [chemical binding]; other site 1173025003867 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1173025003868 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1173025003869 active site 1173025003870 interdomain interaction site; other site 1173025003871 putative metal-binding site [ion binding]; other site 1173025003872 nucleotide binding site [chemical binding]; other site 1173025003873 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1173025003874 domain I; other site 1173025003875 phosphate binding site [ion binding]; other site 1173025003876 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1173025003877 domain II; other site 1173025003878 domain III; other site 1173025003879 nucleotide binding site [chemical binding]; other site 1173025003880 DNA binding groove [nucleotide binding] 1173025003881 catalytic site [active] 1173025003882 domain IV; other site 1173025003883 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1173025003884 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1173025003885 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1173025003886 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1173025003887 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 1173025003888 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173025003889 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 1173025003890 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1173025003891 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 1173025003892 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1173025003893 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1173025003894 active site 1173025003895 SAM binding site [chemical binding]; other site 1173025003896 homodimer interface [polypeptide binding]; other site 1173025003897 Membrane protein of unknown function; Region: DUF360; pfam04020 1173025003898 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173025003899 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025003900 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025003901 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025003902 5-oxoprolinase; Region: PLN02666 1173025003903 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1173025003904 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1173025003905 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1173025003906 M28 Zn-Peptidases; Region: M28_like_1; cd05640 1173025003907 Peptidase family M28; Region: Peptidase_M28; pfam04389 1173025003908 metal binding site [ion binding]; metal-binding site 1173025003909 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1173025003910 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1173025003911 ligand binding site [chemical binding]; other site 1173025003912 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1173025003913 non-specific DNA interactions [nucleotide binding]; other site 1173025003914 DNA binding site [nucleotide binding] 1173025003915 sequence specific DNA binding site [nucleotide binding]; other site 1173025003916 putative cAMP binding site [chemical binding]; other site 1173025003917 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1173025003918 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1173025003919 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1173025003920 Family of unknown function (DUF490); Region: DUF490; pfam04357 1173025003921 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 1173025003922 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1173025003923 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1173025003924 putative active site [active] 1173025003925 VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457 1173025003926 metal ion-dependent adhesion site (MIDAS); other site 1173025003927 VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457 1173025003928 metal ion-dependent adhesion site (MIDAS); other site 1173025003929 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025003930 GAF domain; Region: GAF; pfam01590 1173025003931 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025003932 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025003933 dimer interface [polypeptide binding]; other site 1173025003934 phosphorylation site [posttranslational modification] 1173025003935 putative bicarbonate transporter, IctB family; Region: 2A73; TIGR00947 1173025003936 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1173025003937 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1173025003938 SmpB-tmRNA interface; other site 1173025003939 YCII-related domain; Region: YCII; cl00999 1173025003940 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 1173025003941 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1173025003942 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 1173025003943 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1173025003944 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1173025003945 ATP binding site [chemical binding]; other site 1173025003946 Mg2+ binding site [ion binding]; other site 1173025003947 G-X-G motif; other site 1173025003948 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173025003949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025003950 active site 1173025003951 phosphorylation site [posttranslational modification] 1173025003952 intermolecular recognition site; other site 1173025003953 dimerization interface [polypeptide binding]; other site 1173025003954 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025003955 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1173025003956 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1173025003957 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1173025003958 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 1173025003959 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173025003960 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1173025003961 OstA-like protein; Region: OstA; pfam03968 1173025003962 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1173025003963 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1173025003964 Walker A/P-loop; other site 1173025003965 ATP binding site [chemical binding]; other site 1173025003966 Q-loop/lid; other site 1173025003967 ABC transporter signature motif; other site 1173025003968 Walker B; other site 1173025003969 D-loop; other site 1173025003970 H-loop/switch region; other site 1173025003971 Predicted permeases [General function prediction only]; Region: COG0795 1173025003972 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1173025003973 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 1173025003974 active site 1173025003975 catalytic residues [active] 1173025003976 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1173025003977 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1173025003978 intersubunit interface [polypeptide binding]; other site 1173025003979 active site 1173025003980 zinc binding site [ion binding]; other site 1173025003981 Na+ binding site [ion binding]; other site 1173025003982 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1173025003983 photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042 1173025003984 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173025003985 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173025003986 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1173025003987 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173025003988 dimerization interface [polypeptide binding]; other site 1173025003989 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025003990 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025003991 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025003992 ATP binding site [chemical binding]; other site 1173025003993 Mg2+ binding site [ion binding]; other site 1173025003994 G-X-G motif; other site 1173025003995 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 1173025003996 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1173025003997 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1173025003998 catalytic residues [active] 1173025003999 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1173025004000 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1173025004001 Haemolytic domain; Region: Haemolytic; pfam01809 1173025004002 ribosomal protein S4; Reviewed; Region: rps4; CHL00113 1173025004003 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1173025004004 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1173025004005 RNA binding surface [nucleotide binding]; other site 1173025004006 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 1173025004007 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173025004008 FeS/SAM binding site; other site 1173025004009 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1173025004010 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1173025004011 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 1173025004012 GMP synthase; Reviewed; Region: guaA; PRK00074 1173025004013 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1173025004014 AMP/PPi binding site [chemical binding]; other site 1173025004015 candidate oxyanion hole; other site 1173025004016 catalytic triad [active] 1173025004017 potential glutamine specificity residues [chemical binding]; other site 1173025004018 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1173025004019 ATP Binding subdomain [chemical binding]; other site 1173025004020 Ligand Binding sites [chemical binding]; other site 1173025004021 Dimerization subdomain; other site 1173025004022 Protein of unknown function (DUF561); Region: DUF561; pfam04481 1173025004023 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1173025004024 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173025004025 N-terminal plug; other site 1173025004026 ligand-binding site [chemical binding]; other site 1173025004027 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1173025004028 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1173025004029 active site 1173025004030 ribulose/triose binding site [chemical binding]; other site 1173025004031 phosphate binding site [ion binding]; other site 1173025004032 substrate (anthranilate) binding pocket [chemical binding]; other site 1173025004033 product (indole) binding pocket [chemical binding]; other site 1173025004034 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1173025004035 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1173025004036 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1173025004037 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1173025004038 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 1173025004039 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1173025004040 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173025004041 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1173025004042 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173025004043 motif II; other site 1173025004044 VanW like protein; Region: VanW; pfam04294 1173025004045 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1173025004046 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1173025004047 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1173025004048 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1173025004049 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1173025004050 ATP-sulfurylase; Region: ATPS; cd00517 1173025004051 active site 1173025004052 HXXH motif; other site 1173025004053 flexible loop; other site 1173025004054 Caspase domain; Region: Peptidase_C14; pfam00656 1173025004055 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 1173025004056 MAPEG family; Region: MAPEG; pfam01124 1173025004057 acetolactate synthase; Reviewed; Region: PRK08322 1173025004058 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1173025004059 PYR/PP interface [polypeptide binding]; other site 1173025004060 dimer interface [polypeptide binding]; other site 1173025004061 TPP binding site [chemical binding]; other site 1173025004062 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1173025004063 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1173025004064 TPP-binding site [chemical binding]; other site 1173025004065 dimer interface [polypeptide binding]; other site 1173025004066 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1173025004067 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1173025004068 NAD(P) binding site [chemical binding]; other site 1173025004069 catalytic residues [active] 1173025004070 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 1173025004071 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1173025004072 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 1173025004073 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 1173025004074 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 1173025004075 putative catalytic residues [active] 1173025004076 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1173025004077 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1173025004078 dimer interface [polypeptide binding]; other site 1173025004079 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1173025004080 catalytic triad [active] 1173025004081 peroxidatic and resolving cysteines [active] 1173025004082 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 1173025004083 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 1173025004084 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 1173025004085 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1173025004086 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1173025004087 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1173025004088 Peptidase family M23; Region: Peptidase_M23; pfam01551 1173025004089 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1173025004090 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1173025004091 cytochrome c-550; Provisional; Region: psbV; PRK13621 1173025004092 cytochrome c-550; Provisional; Region: psbV; cl17239 1173025004093 cytochrome c-550; Provisional; Region: psbV; cl17239 1173025004094 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1173025004095 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1173025004096 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 1173025004097 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173025004098 AAA domain; Region: AAA_23; pfam13476 1173025004099 Walker A/P-loop; other site 1173025004100 ATP binding site [chemical binding]; other site 1173025004101 Q-loop/lid; other site 1173025004102 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1173025004103 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173025004104 ABC transporter signature motif; other site 1173025004105 Walker B; other site 1173025004106 D-loop; other site 1173025004107 H-loop/switch region; other site 1173025004108 VCBS repeat; Region: VCBS_repeat; TIGR01965 1173025004109 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1173025004110 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1173025004111 Predicted permeases [General function prediction only]; Region: COG0679 1173025004112 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 1173025004113 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173025004114 active site 1173025004115 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 1173025004116 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025004117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025004118 active site 1173025004119 phosphorylation site [posttranslational modification] 1173025004120 intermolecular recognition site; other site 1173025004121 dimerization interface [polypeptide binding]; other site 1173025004122 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1173025004123 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1173025004124 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1173025004125 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1173025004126 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 1173025004127 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025004128 binding surface 1173025004129 TPR motif; other site 1173025004130 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1173025004131 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1173025004132 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1173025004133 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 1173025004134 [2Fe-2S] cluster binding site [ion binding]; other site 1173025004135 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1173025004136 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1173025004137 substrate binding site [chemical binding]; other site 1173025004138 hexamer interface [polypeptide binding]; other site 1173025004139 metal binding site [ion binding]; metal-binding site 1173025004140 Peptidase S8 family domain, uncharacterized subfamily 2; Region: Peptidases_S8_2; cd07488 1173025004141 putative catalytic residues [active] 1173025004142 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1173025004143 putative active site [active] 1173025004144 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173025004145 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173025004146 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1173025004147 Walker A/P-loop; other site 1173025004148 ATP binding site [chemical binding]; other site 1173025004149 Q-loop/lid; other site 1173025004150 ABC transporter signature motif; other site 1173025004151 Walker B; other site 1173025004152 D-loop; other site 1173025004153 H-loop/switch region; other site 1173025004154 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1173025004155 Part of AAA domain; Region: AAA_19; pfam13245 1173025004156 Family description; Region: UvrD_C_2; pfam13538 1173025004157 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 1173025004158 GIY-YIG motif/motif A; other site 1173025004159 active site 1173025004160 catalytic site [active] 1173025004161 metal binding site [ion binding]; metal-binding site 1173025004162 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173025004163 putative active site [active] 1173025004164 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173025004165 putative active site [active] 1173025004166 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1173025004167 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1173025004168 active site 1173025004169 TDP-binding site; other site 1173025004170 acceptor substrate-binding pocket; other site 1173025004171 homodimer interface [polypeptide binding]; other site 1173025004172 Uncharacterized conserved protein [Function unknown]; Region: COG4278 1173025004173 FeoA domain; Region: FeoA; pfam04023 1173025004174 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1173025004175 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1173025004176 G1 box; other site 1173025004177 GTP/Mg2+ binding site [chemical binding]; other site 1173025004178 Switch I region; other site 1173025004179 G2 box; other site 1173025004180 G3 box; other site 1173025004181 Switch II region; other site 1173025004182 G4 box; other site 1173025004183 G5 box; other site 1173025004184 Nucleoside recognition; Region: Gate; pfam07670 1173025004185 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1173025004186 Nucleoside recognition; Region: Gate; pfam07670 1173025004187 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1173025004188 MarR family; Region: MarR; pfam01047 1173025004189 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1173025004190 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1173025004191 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173025004192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173025004193 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173025004194 putative substrate translocation pore; other site 1173025004195 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173025004196 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 1173025004197 Protein of unknown function (DUF790); Region: DUF790; pfam05626 1173025004198 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1173025004199 Ferritin-like domain; Region: Ferritin; pfam00210 1173025004200 dimanganese center [ion binding]; other site 1173025004201 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 1173025004202 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1173025004203 Zn binding site [ion binding]; other site 1173025004204 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173025004205 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173025004206 S-adenosylmethionine binding site [chemical binding]; other site 1173025004207 hypothetical protein; Provisional; Region: PRK02509 1173025004208 Uncharacterized conserved protein [Function unknown]; Region: COG1615 1173025004209 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1173025004210 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1173025004211 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1173025004212 tRNA; other site 1173025004213 putative tRNA binding site [nucleotide binding]; other site 1173025004214 putative NADP binding site [chemical binding]; other site 1173025004215 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1173025004216 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1173025004217 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1173025004218 putative active site [active] 1173025004219 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1173025004220 GSH binding site [chemical binding]; other site 1173025004221 catalytic residues [active] 1173025004222 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1173025004223 nucleoside/Zn binding site; other site 1173025004224 dimer interface [polypeptide binding]; other site 1173025004225 catalytic motif [active] 1173025004226 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1173025004227 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1173025004228 putative acyl-acceptor binding pocket; other site 1173025004229 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1173025004230 Peptidase S8 family domain, uncharacterized subfamily 15; Region: Peptidases_S8_15; cd07498 1173025004231 active site 1173025004232 catalytic triad [active] 1173025004233 Regulatory P domain of the subtilisin-like proprotein convertases and other proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG4935 1173025004234 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 1173025004235 BolA-like protein; Region: BolA; pfam01722 1173025004236 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1173025004237 putative GSH binding site [chemical binding]; other site 1173025004238 catalytic residues [active] 1173025004239 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173025004240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025004241 active site 1173025004242 phosphorylation site [posttranslational modification] 1173025004243 intermolecular recognition site; other site 1173025004244 dimerization interface [polypeptide binding]; other site 1173025004245 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173025004246 DNA binding site [nucleotide binding] 1173025004247 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1173025004248 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 1173025004249 Walker A/P-loop; other site 1173025004250 ATP binding site [chemical binding]; other site 1173025004251 Q-loop/lid; other site 1173025004252 ABC transporter signature motif; other site 1173025004253 Walker B; other site 1173025004254 D-loop; other site 1173025004255 H-loop/switch region; other site 1173025004256 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1173025004257 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1173025004258 active site 1173025004259 metal binding site [ion binding]; metal-binding site 1173025004260 lipoyl synthase; Provisional; Region: PRK05481 1173025004261 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619 1173025004262 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1173025004263 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1173025004264 PRC-barrel domain; Region: PRC; pfam05239 1173025004265 PRC-barrel domain; Region: PRC; pfam05239 1173025004266 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 1173025004267 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1173025004268 Walker A/P-loop; other site 1173025004269 ATP binding site [chemical binding]; other site 1173025004270 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1173025004271 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1173025004272 ABC transporter signature motif; other site 1173025004273 Walker B; other site 1173025004274 D-loop; other site 1173025004275 H-loop/switch region; other site 1173025004276 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 1173025004277 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1173025004278 Amidase; Region: Amidase; pfam01425 1173025004279 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 1173025004280 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1173025004281 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1173025004282 homodimer interface [polypeptide binding]; other site 1173025004283 NADP binding site [chemical binding]; other site 1173025004284 substrate binding site [chemical binding]; other site 1173025004285 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1173025004286 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1173025004287 substrate binding pocket [chemical binding]; other site 1173025004288 chain length determination region; other site 1173025004289 substrate-Mg2+ binding site; other site 1173025004290 catalytic residues [active] 1173025004291 aspartate-rich region 1; other site 1173025004292 active site lid residues [active] 1173025004293 aspartate-rich region 2; other site 1173025004294 Divergent PAP2 family; Region: DUF212; pfam02681 1173025004295 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 1173025004296 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1173025004297 active site 1173025004298 hydrophilic channel; other site 1173025004299 dimerization interface [polypeptide binding]; other site 1173025004300 catalytic residues [active] 1173025004301 active site lid [active] 1173025004302 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1173025004303 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173025004304 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025004305 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025004306 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025004307 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025004308 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025004309 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025004310 cobyric acid synthase; Provisional; Region: PRK00784 1173025004311 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1173025004312 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1173025004313 catalytic triad [active] 1173025004314 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173025004315 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173025004316 catalytic loop [active] 1173025004317 iron binding site [ion binding]; other site 1173025004318 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1173025004319 dimer interface [polypeptide binding]; other site 1173025004320 catalytic residues [active] 1173025004321 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1173025004322 UreF; Region: UreF; pfam01730 1173025004323 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173025004324 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173025004325 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025004326 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025004327 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1173025004328 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 1173025004329 active site 1173025004330 catalytic triad [active] 1173025004331 oxyanion hole [active] 1173025004332 DNA-directed RNA polymerase subunit omega; Provisional; Region: ycf61; CHL00191 1173025004333 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 1173025004334 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1173025004335 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1173025004336 active site 1173025004337 homodimer interface [polypeptide binding]; other site 1173025004338 catalytic site [active] 1173025004339 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1173025004340 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1173025004341 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1173025004342 FtsX-like permease family; Region: FtsX; pfam02687 1173025004343 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1173025004344 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1173025004345 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173025004346 TRX domain, novel NADPH thioredoxin reductase (NTR) family; composed of fusion proteins found only in oxygenic photosynthetic organisms containing both TRX and NTR domains. The TRX domain functions as a protein disulfide reductase via the reversible...; Region: TRX_NTR; cd02949 1173025004347 catalytic residues [active] 1173025004348 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173025004349 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173025004350 active site 1173025004351 ATP binding site [chemical binding]; other site 1173025004352 substrate binding site [chemical binding]; other site 1173025004353 activation loop (A-loop); other site 1173025004354 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1173025004355 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 1173025004356 putative ligand binding site [chemical binding]; other site 1173025004357 Protein of unknown function (DUF456); Region: DUF456; cl01069 1173025004358 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 1173025004359 GAF domain; Region: GAF_2; pfam13185 1173025004360 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1173025004361 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1173025004362 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 1173025004363 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1173025004364 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1173025004365 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1173025004366 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1173025004367 dimerization interface [polypeptide binding]; other site 1173025004368 hypothetical protein; Provisional; Region: PRK07394 1173025004369 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1173025004370 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1173025004371 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1173025004372 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1173025004373 tetramerization interface [polypeptide binding]; other site 1173025004374 active site 1173025004375 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1173025004376 dimer interface [polypeptide binding]; other site 1173025004377 substrate binding site [chemical binding]; other site 1173025004378 metal binding sites [ion binding]; metal-binding site 1173025004379 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025004380 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025004381 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025004382 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025004383 PAS fold; Region: PAS; pfam00989 1173025004384 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025004385 putative active site [active] 1173025004386 heme pocket [chemical binding]; other site 1173025004387 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173025004388 cyclase homology domain; Region: CHD; cd07302 1173025004389 nucleotidyl binding site; other site 1173025004390 metal binding site [ion binding]; metal-binding site 1173025004391 dimer interface [polypeptide binding]; other site 1173025004392 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1173025004393 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173025004394 Walker A/P-loop; other site 1173025004395 ATP binding site [chemical binding]; other site 1173025004396 Q-loop/lid; other site 1173025004397 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1173025004398 ABC transporter signature motif; other site 1173025004399 Walker B; other site 1173025004400 D-loop; other site 1173025004401 H-loop/switch region; other site 1173025004402 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1173025004403 ABC1 family; Region: ABC1; pfam03109 1173025004404 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1173025004405 active site 1173025004406 ATP binding site [chemical binding]; other site 1173025004407 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1173025004408 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1173025004409 HIGH motif; other site 1173025004410 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1173025004411 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1173025004412 active site 1173025004413 KMSKS motif; other site 1173025004414 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1173025004415 tRNA binding surface [nucleotide binding]; other site 1173025004416 anticodon binding site; other site 1173025004417 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1173025004418 phosphoribulokinase; Provisional; Region: PRK07429 1173025004419 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 1173025004420 active site 1173025004421 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 1173025004422 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 1173025004423 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 1173025004424 dimerization interface [polypeptide binding]; other site 1173025004425 FAD binding pocket [chemical binding]; other site 1173025004426 FAD binding motif [chemical binding]; other site 1173025004427 catalytic residues [active] 1173025004428 NAD binding pocket [chemical binding]; other site 1173025004429 phosphate binding motif [ion binding]; other site 1173025004430 beta-alpha-beta structure motif; other site 1173025004431 homoserine dehydrogenase; Provisional; Region: PRK06349 1173025004432 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1173025004433 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1173025004434 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1173025004435 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1173025004436 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 1173025004437 NAD binding site [chemical binding]; other site 1173025004438 dimer interface [polypeptide binding]; other site 1173025004439 substrate binding site [chemical binding]; other site 1173025004440 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1173025004441 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 1173025004442 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1173025004443 dimer interface [polypeptide binding]; other site 1173025004444 [2Fe-2S] cluster binding site [ion binding]; other site 1173025004445 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 1173025004446 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1173025004447 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1173025004448 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1173025004449 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1173025004450 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1173025004451 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1173025004452 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1173025004453 ATP-grasp domain; Region: ATP-grasp; pfam02222 1173025004454 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 1173025004455 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1173025004456 P loop; other site 1173025004457 Nucleotide binding site [chemical binding]; other site 1173025004458 DTAP/Switch II; other site 1173025004459 Switch I; other site 1173025004460 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1173025004461 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173025004462 putative active site [active] 1173025004463 Ion channel; Region: Ion_trans_2; pfam07885 1173025004464 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1173025004465 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 1173025004466 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1173025004467 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1173025004468 Moco binding site; other site 1173025004469 metal coordination site [ion binding]; other site 1173025004470 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1173025004471 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173025004472 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1173025004473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173025004474 NAD(P) binding site [chemical binding]; other site 1173025004475 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1173025004476 Rubredoxin; Region: Rubredoxin; pfam00301 1173025004477 iron binding site [ion binding]; other site 1173025004478 GUN4-like; Region: GUN4; pfam05419 1173025004479 Cache domain; Region: Cache_1; pfam02743 1173025004480 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025004481 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173025004482 dimerization interface [polypeptide binding]; other site 1173025004483 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025004484 dimer interface [polypeptide binding]; other site 1173025004485 phosphorylation site [posttranslational modification] 1173025004486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025004487 ATP binding site [chemical binding]; other site 1173025004488 Mg2+ binding site [ion binding]; other site 1173025004489 G-X-G motif; other site 1173025004490 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1173025004491 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1173025004492 Walker A/P-loop; other site 1173025004493 ATP binding site [chemical binding]; other site 1173025004494 Q-loop/lid; other site 1173025004495 ABC transporter signature motif; other site 1173025004496 Walker B; other site 1173025004497 D-loop; other site 1173025004498 H-loop/switch region; other site 1173025004499 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1173025004500 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1173025004501 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1173025004502 TM-ABC transporter signature motif; other site 1173025004503 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 1173025004504 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1173025004505 active site 1173025004506 dimer interface [polypeptide binding]; other site 1173025004507 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1173025004508 dimer interface [polypeptide binding]; other site 1173025004509 active site 1173025004510 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1173025004511 NMT1-like family; Region: NMT1_2; pfam13379 1173025004512 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1173025004513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173025004514 dimer interface [polypeptide binding]; other site 1173025004515 conserved gate region; other site 1173025004516 ABC-ATPase subunit interface; other site 1173025004517 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1173025004518 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 1173025004519 Walker A/P-loop; other site 1173025004520 ATP binding site [chemical binding]; other site 1173025004521 Q-loop/lid; other site 1173025004522 ABC transporter signature motif; other site 1173025004523 Walker B; other site 1173025004524 D-loop; other site 1173025004525 H-loop/switch region; other site 1173025004526 NMT1-like family; Region: NMT1_2; pfam13379 1173025004527 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1173025004528 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1173025004529 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 1173025004530 Walker A/P-loop; other site 1173025004531 ATP binding site [chemical binding]; other site 1173025004532 Q-loop/lid; other site 1173025004533 ABC transporter signature motif; other site 1173025004534 Walker B; other site 1173025004535 D-loop; other site 1173025004536 H-loop/switch region; other site 1173025004537 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1173025004538 active site 1173025004539 substrate binding pocket [chemical binding]; other site 1173025004540 dimer interface [polypeptide binding]; other site 1173025004541 Peptidase M15; Region: Peptidase_M15_3; cl01194 1173025004542 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1173025004543 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173025004544 ATP binding site [chemical binding]; other site 1173025004545 putative Mg++ binding site [ion binding]; other site 1173025004546 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173025004547 nucleotide binding region [chemical binding]; other site 1173025004548 ATP-binding site [chemical binding]; other site 1173025004549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025004550 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025004551 active site 1173025004552 phosphorylation site [posttranslational modification] 1173025004553 intermolecular recognition site; other site 1173025004554 dimerization interface [polypeptide binding]; other site 1173025004555 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025004556 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025004557 dimer interface [polypeptide binding]; other site 1173025004558 phosphorylation site [posttranslational modification] 1173025004559 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025004560 ATP binding site [chemical binding]; other site 1173025004561 Mg2+ binding site [ion binding]; other site 1173025004562 G-X-G motif; other site 1173025004563 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025004564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025004565 active site 1173025004566 phosphorylation site [posttranslational modification] 1173025004567 intermolecular recognition site; other site 1173025004568 dimerization interface [polypeptide binding]; other site 1173025004569 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025004570 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025004571 dimer interface [polypeptide binding]; other site 1173025004572 phosphorylation site [posttranslational modification] 1173025004573 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025004574 ATP binding site [chemical binding]; other site 1173025004575 Mg2+ binding site [ion binding]; other site 1173025004576 G-X-G motif; other site 1173025004577 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025004578 GAF domain; Region: GAF_3; pfam13492 1173025004579 PAS domain; Region: PAS_9; pfam13426 1173025004580 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1173025004581 PAS fold; Region: PAS_4; pfam08448 1173025004582 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025004583 putative active site [active] 1173025004584 heme pocket [chemical binding]; other site 1173025004585 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025004586 PAS fold; Region: PAS_3; pfam08447 1173025004587 putative active site [active] 1173025004588 heme pocket [chemical binding]; other site 1173025004589 PAS fold; Region: PAS_3; pfam08447 1173025004590 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025004591 putative active site [active] 1173025004592 PAS fold; Region: PAS_3; pfam08447 1173025004593 heme pocket [chemical binding]; other site 1173025004594 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025004595 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025004596 dimer interface [polypeptide binding]; other site 1173025004597 phosphorylation site [posttranslational modification] 1173025004598 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025004599 ATP binding site [chemical binding]; other site 1173025004600 Mg2+ binding site [ion binding]; other site 1173025004601 G-X-G motif; other site 1173025004602 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025004603 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025004604 active site 1173025004605 phosphorylation site [posttranslational modification] 1173025004606 intermolecular recognition site; other site 1173025004607 dimerization interface [polypeptide binding]; other site 1173025004608 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 1173025004609 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 1173025004610 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173025004611 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 1173025004612 Probable transposase; Region: OrfB_IS605; pfam01385 1173025004613 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173025004614 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173025004615 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1173025004616 putative ADP-binding pocket [chemical binding]; other site 1173025004617 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173025004618 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1173025004619 putative ADP-binding pocket [chemical binding]; other site 1173025004620 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1173025004621 D-xylulose kinase; Region: XylB; TIGR01312 1173025004622 nucleotide binding site [chemical binding]; other site 1173025004623 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 1173025004624 S-layer homology domain; Region: SLH; pfam00395 1173025004625 S-layer homology domain; Region: SLH; pfam00395 1173025004626 S-layer homology domain; Region: SLH; pfam00395 1173025004627 S-layer homology domain; Region: SLH; pfam00395 1173025004628 Predicted membrane protein [Function unknown]; Region: COG2259 1173025004629 Protein of unknown function (DUF433); Region: DUF433; pfam04255 1173025004630 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1173025004631 Histone deacetylase domain; Region: Hist_deacetyl; pfam00850 1173025004632 active site 1173025004633 metal binding site [ion binding]; metal-binding site 1173025004634 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173025004635 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173025004636 metal binding site [ion binding]; metal-binding site 1173025004637 active site 1173025004638 I-site; other site 1173025004639 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 1173025004640 Divergent AAA domain; Region: AAA_4; pfam04326 1173025004641 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1173025004642 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1173025004643 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173025004644 P-loop; other site 1173025004645 Magnesium ion binding site [ion binding]; other site 1173025004646 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173025004647 Magnesium ion binding site [ion binding]; other site 1173025004648 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173025004649 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173025004650 S-adenosylmethionine binding site [chemical binding]; other site 1173025004651 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1173025004652 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1173025004653 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1173025004654 active site 1173025004655 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1173025004656 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1173025004657 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1173025004658 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173025004659 active site 1173025004660 motif I; other site 1173025004661 motif II; other site 1173025004662 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 1173025004663 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1173025004664 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1173025004665 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1173025004666 putative acyl-acceptor binding pocket; other site 1173025004667 endonuclease VIII; Provisional; Region: PRK10445 1173025004668 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 1173025004669 DNA binding site [nucleotide binding] 1173025004670 catalytic residue [active] 1173025004671 H2TH interface [polypeptide binding]; other site 1173025004672 putative catalytic residues [active] 1173025004673 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1173025004674 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1173025004675 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173025004676 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025004677 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173025004678 S-adenosylmethionine binding site [chemical binding]; other site 1173025004679 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1173025004680 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1173025004681 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173025004682 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1173025004683 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1173025004684 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1173025004685 putative ligand binding site [chemical binding]; other site 1173025004686 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1173025004687 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1173025004688 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1173025004689 TM-ABC transporter signature motif; other site 1173025004690 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1173025004691 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1173025004692 TM-ABC transporter signature motif; other site 1173025004693 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1173025004694 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1173025004695 Walker A/P-loop; other site 1173025004696 ATP binding site [chemical binding]; other site 1173025004697 Q-loop/lid; other site 1173025004698 ABC transporter signature motif; other site 1173025004699 Walker B; other site 1173025004700 D-loop; other site 1173025004701 H-loop/switch region; other site 1173025004702 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1173025004703 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1173025004704 Walker A/P-loop; other site 1173025004705 ATP binding site [chemical binding]; other site 1173025004706 Q-loop/lid; other site 1173025004707 ABC transporter signature motif; other site 1173025004708 Walker B; other site 1173025004709 D-loop; other site 1173025004710 H-loop/switch region; other site 1173025004711 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 1173025004712 DNA polymerase III subunit delta; Validated; Region: PRK07452 1173025004713 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1173025004714 precorrin-8X methylmutase; Provisional; Region: PRK05954 1173025004715 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1173025004716 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1173025004717 active site 1173025004718 putative homodimer interface [polypeptide binding]; other site 1173025004719 SAM binding site [chemical binding]; other site 1173025004720 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1173025004721 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173025004722 S-adenosylmethionine binding site [chemical binding]; other site 1173025004723 CAAX protease self-immunity; Region: Abi; pfam02517 1173025004724 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 1173025004725 succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577 1173025004726 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1173025004727 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 1173025004728 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 1173025004729 Photosystem II reaction centre X protein (PsbX); Region: PsbX; cl05887 1173025004730 Predicted integral membrane protein [Function unknown]; Region: COG0762 1173025004731 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1173025004732 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1173025004733 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1173025004734 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1173025004735 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025004736 PAS domain; Region: PAS_9; pfam13426 1173025004737 putative active site [active] 1173025004738 heme pocket [chemical binding]; other site 1173025004739 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025004740 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173025004741 putative active site [active] 1173025004742 heme pocket [chemical binding]; other site 1173025004743 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025004744 putative active site [active] 1173025004745 heme pocket [chemical binding]; other site 1173025004746 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025004747 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025004748 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025004749 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025004750 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025004751 dimer interface [polypeptide binding]; other site 1173025004752 phosphorylation site [posttranslational modification] 1173025004753 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025004754 ATP binding site [chemical binding]; other site 1173025004755 Mg2+ binding site [ion binding]; other site 1173025004756 G-X-G motif; other site 1173025004757 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173025004758 PAS fold; Region: PAS; pfam00989 1173025004759 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025004760 putative active site [active] 1173025004761 heme pocket [chemical binding]; other site 1173025004762 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025004763 dimer interface [polypeptide binding]; other site 1173025004764 phosphorylation site [posttranslational modification] 1173025004765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025004766 ATP binding site [chemical binding]; other site 1173025004767 Mg2+ binding site [ion binding]; other site 1173025004768 G-X-G motif; other site 1173025004769 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1173025004770 4Fe-4S binding domain; Region: Fer4; pfam00037 1173025004771 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1173025004772 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173025004773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025004774 active site 1173025004775 phosphorylation site [posttranslational modification] 1173025004776 intermolecular recognition site; other site 1173025004777 dimerization interface [polypeptide binding]; other site 1173025004778 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173025004779 DNA binding residues [nucleotide binding] 1173025004780 dimerization interface [polypeptide binding]; other site 1173025004781 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1173025004782 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1173025004783 N- and C-terminal domain interface [polypeptide binding]; other site 1173025004784 active site 1173025004785 catalytic site [active] 1173025004786 metal binding site [ion binding]; metal-binding site 1173025004787 carbohydrate binding site [chemical binding]; other site 1173025004788 ATP binding site [chemical binding]; other site 1173025004789 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1173025004790 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1173025004791 active site residue [active] 1173025004792 putative active site [active] 1173025004793 putative metal binding site [ion binding]; other site 1173025004794 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1173025004795 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173025004796 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173025004797 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025004798 glutamyl-tRNA(Gln) amidotransferase subunit E; Validated; Region: PRK04028 1173025004799 SnoaL-like domain; Region: SnoaL_2; pfam12680 1173025004800 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 1173025004801 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1173025004802 metal ion-dependent adhesion site (MIDAS); other site 1173025004803 MoxR-like ATPases [General function prediction only]; Region: COG0714 1173025004804 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1173025004805 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1173025004806 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1173025004807 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1173025004808 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1173025004809 substrate binding site [chemical binding]; other site 1173025004810 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1173025004811 substrate binding site [chemical binding]; other site 1173025004812 ligand binding site [chemical binding]; other site 1173025004813 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 1173025004814 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 1173025004815 MORN repeat; Region: MORN; pfam02493 1173025004816 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 1173025004817 MORN repeat; Region: MORN; cl14787 1173025004818 Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases; Region: MORN; smart00698 1173025004819 EVE domain; Region: EVE; cl00728 1173025004820 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1173025004821 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173025004822 dimer interface [polypeptide binding]; other site 1173025004823 conserved gate region; other site 1173025004824 putative PBP binding loops; other site 1173025004825 ABC-ATPase subunit interface; other site 1173025004826 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025004827 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025004828 GAF domain; Region: GAF_2; pfam13185 1173025004829 GAF domain; Region: GAF; pfam01590 1173025004830 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025004831 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025004832 dimer interface [polypeptide binding]; other site 1173025004833 phosphorylation site [posttranslational modification] 1173025004834 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025004835 ATP binding site [chemical binding]; other site 1173025004836 Mg2+ binding site [ion binding]; other site 1173025004837 G-X-G motif; other site 1173025004838 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1173025004839 pseudouridine synthase; Region: TIGR00093 1173025004840 active site 1173025004841 CHASE2 domain; Region: CHASE2; pfam05226 1173025004842 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025004843 dimer interface [polypeptide binding]; other site 1173025004844 phosphorylation site [posttranslational modification] 1173025004845 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025004846 ATP binding site [chemical binding]; other site 1173025004847 Mg2+ binding site [ion binding]; other site 1173025004848 G-X-G motif; other site 1173025004849 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025004850 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025004851 active site 1173025004852 phosphorylation site [posttranslational modification] 1173025004853 intermolecular recognition site; other site 1173025004854 dimerization interface [polypeptide binding]; other site 1173025004855 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025004856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025004857 active site 1173025004858 phosphorylation site [posttranslational modification] 1173025004859 intermolecular recognition site; other site 1173025004860 dimerization interface [polypeptide binding]; other site 1173025004861 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 1173025004862 FecR protein; Region: FecR; pfam04773 1173025004863 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 1173025004864 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 1173025004865 active site 1173025004866 catalytic residues [active] 1173025004867 metal binding site [ion binding]; metal-binding site 1173025004868 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1173025004869 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173025004870 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173025004871 catalytic loop [active] 1173025004872 iron binding site [ion binding]; other site 1173025004873 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1173025004874 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1173025004875 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1173025004876 ThiS interaction site; other site 1173025004877 putative active site [active] 1173025004878 tetramer interface [polypeptide binding]; other site 1173025004879 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1173025004880 aspartate aminotransferase; Provisional; Region: PRK05957 1173025004881 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1173025004882 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173025004883 homodimer interface [polypeptide binding]; other site 1173025004884 catalytic residue [active] 1173025004885 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1173025004886 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1173025004887 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1173025004888 iron-sulfur cluster [ion binding]; other site 1173025004889 [2Fe-2S] cluster binding site [ion binding]; other site 1173025004890 Protein of unknown function DUF72; Region: DUF72; pfam01904 1173025004891 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173025004892 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025004893 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025004894 Protein kinase domain; Region: Pkinase; pfam00069 1173025004895 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173025004896 active site 1173025004897 ATP binding site [chemical binding]; other site 1173025004898 substrate binding site [chemical binding]; other site 1173025004899 activation loop (A-loop); other site 1173025004900 AAA ATPase domain; Region: AAA_16; pfam13191 1173025004901 Predicted ATPase [General function prediction only]; Region: COG3899 1173025004902 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025004903 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025004904 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025004905 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025004906 dimer interface [polypeptide binding]; other site 1173025004907 phosphorylation site [posttranslational modification] 1173025004908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025004909 ATP binding site [chemical binding]; other site 1173025004910 Mg2+ binding site [ion binding]; other site 1173025004911 G-X-G motif; other site 1173025004912 cathepsin C-like protein; Provisional; Region: PTZ00049 1173025004913 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173025004914 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1173025004915 Probable transposase; Region: OrfB_IS605; pfam01385 1173025004916 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173025004917 S-layer homology domain; Region: SLH; pfam00395 1173025004918 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 1173025004919 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173025004920 Coenzyme A binding pocket [chemical binding]; other site 1173025004921 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1173025004922 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1173025004923 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1173025004924 Sporulation and spore germination; Region: Germane; pfam10646 1173025004925 chaperone protein DnaJ; Provisional; Region: PRK14299 1173025004926 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173025004927 HSP70 interaction site [polypeptide binding]; other site 1173025004928 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1173025004929 substrate binding site [polypeptide binding]; other site 1173025004930 dimer interface [polypeptide binding]; other site 1173025004931 AAA domain; Region: AAA_33; pfam13671 1173025004932 AAA domain; Region: AAA_17; pfam13207 1173025004933 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 1173025004934 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1173025004935 ligand binding site; other site 1173025004936 oligomer interface; other site 1173025004937 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1173025004938 dimer interface [polypeptide binding]; other site 1173025004939 N-terminal domain interface [polypeptide binding]; other site 1173025004940 sulfate 1 binding site; other site 1173025004941 Caspase domain; Region: Peptidase_C14; pfam00656 1173025004942 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173025004943 Walker A/P-loop; other site 1173025004944 ATP binding site [chemical binding]; other site 1173025004945 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173025004946 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1173025004947 structural tetrad; other site 1173025004948 Protein of unknown function (DUF2393); Region: DUF2393; pfam09624 1173025004949 TIGR02588 family protein; Region: TIGR02588 1173025004950 Putative integral membrane protein (DUF2391); Region: DUF2391; pfam09622 1173025004951 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1173025004952 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1173025004953 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173025004954 ATP binding site [chemical binding]; other site 1173025004955 putative Mg++ binding site [ion binding]; other site 1173025004956 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173025004957 nucleotide binding region [chemical binding]; other site 1173025004958 ATP-binding site [chemical binding]; other site 1173025004959 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1173025004960 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173025004961 Ligand Binding Site [chemical binding]; other site 1173025004962 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025004963 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173025004964 TPR motif; other site 1173025004965 binding surface 1173025004966 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1173025004967 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1173025004968 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 1173025004969 Domain of unknown function DUF87; Region: DUF87; pfam01935 1173025004970 AAA-like domain; Region: AAA_10; pfam12846 1173025004971 NurA nuclease; Region: NurA; smart00933 1173025004972 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1173025004973 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173025004974 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1173025004975 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1173025004976 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1173025004977 active site 1173025004978 HIGH motif; other site 1173025004979 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1173025004980 KMSKS motif; other site 1173025004981 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1173025004982 tRNA binding surface [nucleotide binding]; other site 1173025004983 anticodon binding site; other site 1173025004984 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1173025004985 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173025004986 NAD(P) binding site [chemical binding]; other site 1173025004987 active site 1173025004988 Domain of unknown function (DUF1993); Region: DUF1993; cl01567 1173025004989 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173025004990 FeS/SAM binding site; other site 1173025004991 Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184 1173025004992 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173025004993 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1173025004994 Coenzyme A binding pocket [chemical binding]; other site 1173025004995 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1173025004996 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1173025004997 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173025004998 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1173025004999 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173025005000 precorrin-8X methylmutase; Validated; Region: PRK05953 1173025005001 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1173025005002 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 1173025005003 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 1173025005004 Ligand Binding Site [chemical binding]; other site 1173025005005 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1173025005006 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1173025005007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173025005008 dimer interface [polypeptide binding]; other site 1173025005009 conserved gate region; other site 1173025005010 putative PBP binding loops; other site 1173025005011 ABC-ATPase subunit interface; other site 1173025005012 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1173025005013 dinuclear metal binding motif [ion binding]; other site 1173025005014 acyl-ACP reductase; Provisional; Region: PRK14982 1173025005015 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1173025005016 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173025005017 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1173025005018 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1173025005019 short chain dehydrogenase; Provisional; Region: PRK07454 1173025005020 classical (c) SDRs; Region: SDR_c; cd05233 1173025005021 NAD(P) binding site [chemical binding]; other site 1173025005022 active site 1173025005023 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1173025005024 homodecamer interface [polypeptide binding]; other site 1173025005025 GTP cyclohydrolase I; Provisional; Region: PLN03044 1173025005026 active site 1173025005027 putative catalytic site residues [active] 1173025005028 zinc binding site [ion binding]; other site 1173025005029 GTP-CH-I/GFRP interaction surface; other site 1173025005030 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1173025005031 active site 1173025005032 photosystem I reaction center subunit PsaK; Region: PS_I_psaK; TIGR03049 1173025005033 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 1173025005034 Peptidase family M50; Region: Peptidase_M50; pfam02163 1173025005035 active site 1173025005036 putative substrate binding region [chemical binding]; other site 1173025005037 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 1173025005038 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1173025005039 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1173025005040 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1173025005041 dinuclear metal binding motif [ion binding]; other site 1173025005042 glutamine synthetase, type I; Region: GlnA; TIGR00653 1173025005043 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1173025005044 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1173025005045 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1173025005046 allophycocyanin, beta subunit; Region: apcB; TIGR01337 1173025005047 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 1173025005048 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1173025005049 NADP binding site [chemical binding]; other site 1173025005050 active site 1173025005051 putative substrate binding site [chemical binding]; other site 1173025005052 flavoprotein, HI0933 family; Region: TIGR00275 1173025005053 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1173025005054 HEAT repeats; Region: HEAT_2; pfam13646 1173025005055 HEAT repeats; Region: HEAT_2; pfam13646 1173025005056 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 1173025005057 protein binding surface [polypeptide binding]; other site 1173025005058 HEAT repeats; Region: HEAT_2; pfam13646 1173025005059 NurA domain; Region: NurA; pfam09376 1173025005060 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1173025005061 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173025005062 active site 1173025005063 motif I; other site 1173025005064 motif II; other site 1173025005065 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1173025005066 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1173025005067 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173025005068 Peptidase family M48; Region: Peptidase_M48; pfam01435 1173025005069 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1173025005070 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173025005071 active site 1173025005072 metal binding site [ion binding]; metal-binding site 1173025005073 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 1173025005074 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173025005075 Ligand Binding Site [chemical binding]; other site 1173025005076 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025005077 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173025005078 dimerization interface [polypeptide binding]; other site 1173025005079 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025005080 dimer interface [polypeptide binding]; other site 1173025005081 phosphorylation site [posttranslational modification] 1173025005082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025005083 ATP binding site [chemical binding]; other site 1173025005084 Mg2+ binding site [ion binding]; other site 1173025005085 G-X-G motif; other site 1173025005086 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173025005087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025005088 active site 1173025005089 phosphorylation site [posttranslational modification] 1173025005090 intermolecular recognition site; other site 1173025005091 dimerization interface [polypeptide binding]; other site 1173025005092 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173025005093 DNA binding site [nucleotide binding] 1173025005094 Uncharacterized conserved protein [Function unknown]; Region: COG4095 1173025005095 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1173025005096 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1173025005097 Walker A/P-loop; other site 1173025005098 ATP binding site [chemical binding]; other site 1173025005099 Q-loop/lid; other site 1173025005100 ABC transporter signature motif; other site 1173025005101 Walker B; other site 1173025005102 D-loop; other site 1173025005103 H-loop/switch region; other site 1173025005104 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025005105 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173025005106 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025005107 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025005108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025005109 active site 1173025005110 phosphorylation site [posttranslational modification] 1173025005111 intermolecular recognition site; other site 1173025005112 dimerization interface [polypeptide binding]; other site 1173025005113 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 1173025005114 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025005115 GAF domain; Region: GAF; pfam01590 1173025005116 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025005117 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025005118 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025005119 dimer interface [polypeptide binding]; other site 1173025005120 phosphorylation site [posttranslational modification] 1173025005121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025005122 ATP binding site [chemical binding]; other site 1173025005123 Mg2+ binding site [ion binding]; other site 1173025005124 G-X-G motif; other site 1173025005125 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173025005126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025005127 active site 1173025005128 phosphorylation site [posttranslational modification] 1173025005129 intermolecular recognition site; other site 1173025005130 dimerization interface [polypeptide binding]; other site 1173025005131 hydrolase, alpha/beta fold family protein; Region: PLN02824 1173025005132 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1173025005133 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1173025005134 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173025005135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025005136 active site 1173025005137 phosphorylation site [posttranslational modification] 1173025005138 dimerization interface [polypeptide binding]; other site 1173025005139 PAS domain S-box; Region: sensory_box; TIGR00229 1173025005140 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025005141 putative active site [active] 1173025005142 heme pocket [chemical binding]; other site 1173025005143 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1173025005144 cyclase homology domain; Region: CHD; cd07302 1173025005145 nucleotidyl binding site; other site 1173025005146 metal binding site [ion binding]; metal-binding site 1173025005147 dimer interface [polypeptide binding]; other site 1173025005148 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025005149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025005150 active site 1173025005151 phosphorylation site [posttranslational modification] 1173025005152 intermolecular recognition site; other site 1173025005153 dimerization interface [polypeptide binding]; other site 1173025005154 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025005155 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025005156 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173025005157 metal binding site [ion binding]; metal-binding site 1173025005158 active site 1173025005159 I-site; other site 1173025005160 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1173025005161 RuvA N terminal domain; Region: RuvA_N; pfam01330 1173025005162 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1173025005163 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 1173025005164 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1173025005165 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173025005166 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173025005167 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173025005168 Walker A/P-loop; other site 1173025005169 ATP binding site [chemical binding]; other site 1173025005170 Q-loop/lid; other site 1173025005171 ABC transporter signature motif; other site 1173025005172 Walker B; other site 1173025005173 D-loop; other site 1173025005174 H-loop/switch region; other site 1173025005175 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1173025005176 putative active site [active] 1173025005177 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025005178 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173025005179 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025005180 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025005181 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025005182 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025005183 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025005184 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025005185 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 1173025005186 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1173025005187 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1173025005188 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1173025005189 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1173025005190 NAD binding site [chemical binding]; other site 1173025005191 homodimer interface [polypeptide binding]; other site 1173025005192 active site 1173025005193 substrate binding site [chemical binding]; other site 1173025005194 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1173025005195 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1173025005196 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1173025005197 Sterol carrier protein domain; Region: SCP2_2; pfam13530 1173025005198 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1173025005199 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396 1173025005200 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1173025005201 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 1173025005202 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1173025005203 16S/18S rRNA binding site [nucleotide binding]; other site 1173025005204 S13e-L30e interaction site [polypeptide binding]; other site 1173025005205 25S rRNA binding site [nucleotide binding]; other site 1173025005206 Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069 1173025005207 glutamate-1-semialdehyde 2,1-aminomutase; Region: PLN02482 1173025005208 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1173025005209 inhibitor-cofactor binding pocket; inhibition site 1173025005210 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173025005211 catalytic residue [active] 1173025005212 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1173025005213 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1173025005214 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1173025005215 metal binding site [ion binding]; metal-binding site 1173025005216 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 1173025005217 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173025005218 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025005219 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025005220 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025005221 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025005222 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025005223 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025005224 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025005225 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 1173025005226 putative hexamer interface [polypeptide binding]; other site 1173025005227 putative hexagonal pore; other site 1173025005228 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 1173025005229 Hexamer interface [polypeptide binding]; other site 1173025005230 Hexagonal pore residue; other site 1173025005231 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025005232 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173025005233 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025005234 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025005235 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025005236 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025005237 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025005238 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1173025005239 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1173025005240 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1173025005241 DNA methylase; Region: N6_N4_Mtase; pfam01555 1173025005242 Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932 1173025005243 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1173025005244 putative lipid kinase; Reviewed; Region: PRK13057 1173025005245 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1173025005246 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1173025005247 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173025005248 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1173025005249 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173025005250 motif II; other site 1173025005251 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1173025005252 recombination protein F; Reviewed; Region: recF; PRK00064 1173025005253 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1173025005254 Walker A/P-loop; other site 1173025005255 ATP binding site [chemical binding]; other site 1173025005256 Q-loop/lid; other site 1173025005257 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173025005258 ABC transporter signature motif; other site 1173025005259 Walker B; other site 1173025005260 D-loop; other site 1173025005261 H-loop/switch region; other site 1173025005262 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025005263 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025005264 active site 1173025005265 phosphorylation site [posttranslational modification] 1173025005266 intermolecular recognition site; other site 1173025005267 dimerization interface [polypeptide binding]; other site 1173025005268 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173025005269 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173025005270 metal binding site [ion binding]; metal-binding site 1173025005271 active site 1173025005272 I-site; other site 1173025005273 CHASE domain; Region: CHASE; cl01369 1173025005274 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025005275 PAS domain; Region: PAS_9; pfam13426 1173025005276 putative active site [active] 1173025005277 heme pocket [chemical binding]; other site 1173025005278 PAS domain S-box; Region: sensory_box; TIGR00229 1173025005279 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025005280 putative active site [active] 1173025005281 heme pocket [chemical binding]; other site 1173025005282 PAS domain; Region: PAS_8; pfam13188 1173025005283 PAS fold; Region: PAS_7; pfam12860 1173025005284 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025005285 GAF domain; Region: GAF; pfam01590 1173025005286 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025005287 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025005288 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025005289 dimer interface [polypeptide binding]; other site 1173025005290 phosphorylation site [posttranslational modification] 1173025005291 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025005292 ATP binding site [chemical binding]; other site 1173025005293 Mg2+ binding site [ion binding]; other site 1173025005294 G-X-G motif; other site 1173025005295 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173025005296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025005297 active site 1173025005298 phosphorylation site [posttranslational modification] 1173025005299 intermolecular recognition site; other site 1173025005300 dimerization interface [polypeptide binding]; other site 1173025005301 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025005302 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025005303 active site 1173025005304 phosphorylation site [posttranslational modification] 1173025005305 intermolecular recognition site; other site 1173025005306 dimerization interface [polypeptide binding]; other site 1173025005307 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 1173025005308 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1173025005309 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1173025005310 homodimer interface [polypeptide binding]; other site 1173025005311 metal binding site [ion binding]; metal-binding site 1173025005312 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1173025005313 homodimer interface [polypeptide binding]; other site 1173025005314 active site 1173025005315 putative chemical substrate binding site [chemical binding]; other site 1173025005316 metal binding site [ion binding]; metal-binding site 1173025005317 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1173025005318 putative catalytic cysteine [active] 1173025005319 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1173025005320 homooctamer interface [polypeptide binding]; other site 1173025005321 active site 1173025005322 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1173025005323 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1173025005324 putative active site [active] 1173025005325 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1173025005326 putative active site [active] 1173025005327 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025005328 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025005329 binding surface 1173025005330 TPR motif; other site 1173025005331 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025005332 binding surface 1173025005333 TPR motif; other site 1173025005334 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025005335 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025005336 PRC-barrel domain; Region: PRC; pfam05239 1173025005337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 1173025005338 magnesium chelatase subunit H; Provisional; Region: PLN03241 1173025005339 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1173025005340 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1173025005341 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1173025005342 DNA protecting protein DprA; Region: dprA; TIGR00732 1173025005343 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1173025005344 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1173025005345 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173025005346 nucleotide binding region [chemical binding]; other site 1173025005347 ATP-binding site [chemical binding]; other site 1173025005348 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 1173025005349 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1173025005350 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1173025005351 active site 1173025005352 Zn binding site [ion binding]; other site 1173025005353 Gas vesicle protein G; Region: GvpG; pfam05120 1173025005354 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 1173025005355 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173025005356 Probable transposase; Region: OrfB_IS605; pfam01385 1173025005357 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173025005358 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 1173025005359 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173025005360 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1173025005361 catalytic site [active] 1173025005362 Caspase domain; Region: Peptidase_C14; pfam00656 1173025005363 AAA ATPase domain; Region: AAA_16; pfam13191 1173025005364 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173025005365 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1173025005366 structural tetrad; other site 1173025005367 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173025005368 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173025005369 structural tetrad; other site 1173025005370 Thymidylate synthase complementing protein; Region: Thy1; cl03630 1173025005371 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173025005372 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173025005373 structural tetrad; other site 1173025005374 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1173025005375 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1173025005376 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1173025005377 NodB motif; other site 1173025005378 active site 1173025005379 catalytic site [active] 1173025005380 metal binding site [ion binding]; metal-binding site 1173025005381 RNA polymerase sigma factor RpoD; Validated; Region: PRK07406 1173025005382 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1173025005383 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173025005384 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1173025005385 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173025005386 DNA binding residues [nucleotide binding] 1173025005387 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1173025005388 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1173025005389 Walker A/P-loop; other site 1173025005390 ATP binding site [chemical binding]; other site 1173025005391 Q-loop/lid; other site 1173025005392 ABC transporter signature motif; other site 1173025005393 Walker B; other site 1173025005394 D-loop; other site 1173025005395 H-loop/switch region; other site 1173025005396 TOBE domain; Region: TOBE_2; pfam08402 1173025005397 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 1173025005398 DNA gyrase subunit A; Validated; Region: PRK05560 1173025005399 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1173025005400 CAP-like domain; other site 1173025005401 active site 1173025005402 primary dimer interface [polypeptide binding]; other site 1173025005403 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1173025005404 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1173025005405 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1173025005406 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1173025005407 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025005408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025005409 active site 1173025005410 phosphorylation site [posttranslational modification] 1173025005411 intermolecular recognition site; other site 1173025005412 dimerization interface [polypeptide binding]; other site 1173025005413 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 1173025005414 spermidine synthase; Provisional; Region: PRK00811 1173025005415 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173025005416 S-adenosylmethionine binding site [chemical binding]; other site 1173025005417 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 1173025005418 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 1173025005419 metal-binding heat shock protein; Provisional; Region: PRK00016 1173025005420 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1173025005421 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1173025005422 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1173025005423 glutamine binding [chemical binding]; other site 1173025005424 catalytic triad [active] 1173025005425 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1173025005426 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1173025005427 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1173025005428 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1173025005429 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1173025005430 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 1173025005431 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 1173025005432 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1173025005433 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1173025005434 Surface antigen; Region: Bac_surface_Ag; pfam01103 1173025005435 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 1173025005436 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1173025005437 CHASE2 domain; Region: CHASE2; pfam05226 1173025005438 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173025005439 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 1173025005440 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 1173025005441 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1173025005442 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 1173025005443 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025005444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 1173025005445 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1173025005446 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1173025005447 Di-iron ligands [ion binding]; other site 1173025005448 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1173025005449 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1173025005450 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1173025005451 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025005452 PAS domain; Region: PAS_9; pfam13426 1173025005453 putative active site [active] 1173025005454 heme pocket [chemical binding]; other site 1173025005455 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025005456 PAS fold; Region: PAS_3; pfam08447 1173025005457 putative active site [active] 1173025005458 heme pocket [chemical binding]; other site 1173025005459 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025005460 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025005461 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025005462 dimer interface [polypeptide binding]; other site 1173025005463 phosphorylation site [posttranslational modification] 1173025005464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025005465 ATP binding site [chemical binding]; other site 1173025005466 Mg2+ binding site [ion binding]; other site 1173025005467 G-X-G motif; other site 1173025005468 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025005469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025005470 active site 1173025005471 phosphorylation site [posttranslational modification] 1173025005472 intermolecular recognition site; other site 1173025005473 dimerization interface [polypeptide binding]; other site 1173025005474 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173025005475 putative active site [active] 1173025005476 MASE1; Region: MASE1; pfam05231 1173025005477 PAS fold; Region: PAS_4; pfam08448 1173025005478 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173025005479 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173025005480 metal binding site [ion binding]; metal-binding site 1173025005481 active site 1173025005482 I-site; other site 1173025005483 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 1173025005484 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1173025005485 active site residue [active] 1173025005486 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1173025005487 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173025005488 S-adenosylmethionine binding site [chemical binding]; other site 1173025005489 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1173025005490 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1173025005491 substrate binding pocket [chemical binding]; other site 1173025005492 Ion channel; Region: Ion_trans_2; pfam07885 1173025005493 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1173025005494 membrane-bound complex binding site; other site 1173025005495 hinge residues; other site 1173025005496 GAF domain; Region: GAF; pfam01590 1173025005497 GAF domain; Region: GAF_2; pfam13185 1173025005498 PAS domain S-box; Region: sensory_box; TIGR00229 1173025005499 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025005500 putative active site [active] 1173025005501 heme pocket [chemical binding]; other site 1173025005502 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025005503 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025005504 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025005505 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025005506 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025005507 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025005508 dimer interface [polypeptide binding]; other site 1173025005509 phosphorylation site [posttranslational modification] 1173025005510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025005511 ATP binding site [chemical binding]; other site 1173025005512 Mg2+ binding site [ion binding]; other site 1173025005513 G-X-G motif; other site 1173025005514 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1173025005515 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173025005516 active site 1173025005517 metal binding site [ion binding]; metal-binding site 1173025005518 DNA binding site [nucleotide binding] 1173025005519 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173025005520 binding surface 1173025005521 TPR motif; other site 1173025005522 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025005523 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025005524 binding surface 1173025005525 TPR motif; other site 1173025005526 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025005527 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025005528 binding surface 1173025005529 TPR motif; other site 1173025005530 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025005531 CHAT domain; Region: CHAT; pfam12770 1173025005532 Isochorismatase family; Region: Isochorismatase; pfam00857 1173025005533 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1173025005534 catalytic triad [active] 1173025005535 conserved cis-peptide bond; other site 1173025005536 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173025005537 WD domain, G-beta repeat; Region: WD40; pfam00400 1173025005538 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173025005539 structural tetrad; other site 1173025005540 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173025005541 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173025005542 structural tetrad; other site 1173025005543 WD40 repeats; Region: WD40; smart00320 1173025005544 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1173025005545 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 1173025005546 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1173025005547 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1173025005548 Walker A/P-loop; other site 1173025005549 ATP binding site [chemical binding]; other site 1173025005550 Q-loop/lid; other site 1173025005551 ABC transporter signature motif; other site 1173025005552 Walker B; other site 1173025005553 D-loop; other site 1173025005554 H-loop/switch region; other site 1173025005555 Phytochelatin synthase; Region: Phytochelatin; pfam05023 1173025005556 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1173025005557 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1173025005558 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1173025005559 putative DNA binding site [nucleotide binding]; other site 1173025005560 putative Zn2+ binding site [ion binding]; other site 1173025005561 AsnC family; Region: AsnC_trans_reg; pfam01037 1173025005562 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173025005563 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173025005564 active site 1173025005565 ATP binding site [chemical binding]; other site 1173025005566 substrate binding site [chemical binding]; other site 1173025005567 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1173025005568 substrate binding site [chemical binding]; other site 1173025005569 activation loop (A-loop); other site 1173025005570 activation loop (A-loop); other site 1173025005571 AAA ATPase domain; Region: AAA_16; pfam13191 1173025005572 Predicted ATPase [General function prediction only]; Region: COG3899 1173025005573 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025005574 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025005575 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173025005576 cyclase homology domain; Region: CHD; cd07302 1173025005577 nucleotidyl binding site; other site 1173025005578 metal binding site [ion binding]; metal-binding site 1173025005579 dimer interface [polypeptide binding]; other site 1173025005580 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1173025005581 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173025005582 dimerization interface [polypeptide binding]; other site 1173025005583 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025005584 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025005585 dimer interface [polypeptide binding]; other site 1173025005586 phosphorylation site [posttranslational modification] 1173025005587 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025005588 ATP binding site [chemical binding]; other site 1173025005589 Mg2+ binding site [ion binding]; other site 1173025005590 G-X-G motif; other site 1173025005591 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1173025005592 Amidinotransferase; Region: Amidinotransf; pfam02274 1173025005593 Uncharacterized conserved protein [Function unknown]; Region: COG1915 1173025005594 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144 1173025005595 homodimer interface [polypeptide binding]; other site 1173025005596 DNA primase; Validated; Region: dnaG; PRK05667 1173025005597 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1173025005598 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1173025005599 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1173025005600 active site 1173025005601 metal binding site [ion binding]; metal-binding site 1173025005602 interdomain interaction site; other site 1173025005603 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1173025005604 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025005605 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173025005606 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025005607 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025005608 hypothetical protein; Reviewed; Region: PRK12497 1173025005609 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1173025005610 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1173025005611 Caspase domain; Region: Peptidase_C14; pfam00656 1173025005612 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 1173025005613 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025005614 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025005615 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025005616 TPR motif; other site 1173025005617 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025005618 binding surface 1173025005619 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025005620 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025005621 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025005622 binding surface 1173025005623 TPR motif; other site 1173025005624 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025005625 TPR repeat; Region: TPR_11; pfam13414 1173025005626 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025005627 binding surface 1173025005628 TPR motif; other site 1173025005629 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025005630 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025005631 binding surface 1173025005632 TPR motif; other site 1173025005633 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025005634 binding surface 1173025005635 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025005636 TPR motif; other site 1173025005637 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025005638 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025005639 CHAT domain; Region: CHAT; cl17868 1173025005640 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1173025005641 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1173025005642 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1173025005643 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1173025005644 putative NAD(P) binding site [chemical binding]; other site 1173025005645 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1173025005646 dimer interface [polypeptide binding]; other site 1173025005647 [2Fe-2S] cluster binding site [ion binding]; other site 1173025005648 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1173025005649 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1173025005650 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1173025005651 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1173025005652 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1173025005653 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1173025005654 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1173025005655 ABC-ATPase subunit interface; other site 1173025005656 dimer interface [polypeptide binding]; other site 1173025005657 putative PBP binding regions; other site 1173025005658 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1173025005659 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1173025005660 ABC-ATPase subunit interface; other site 1173025005661 dimer interface [polypeptide binding]; other site 1173025005662 putative PBP binding regions; other site 1173025005663 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1173025005664 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1173025005665 Walker A/P-loop; other site 1173025005666 ATP binding site [chemical binding]; other site 1173025005667 Q-loop/lid; other site 1173025005668 ABC transporter signature motif; other site 1173025005669 Walker B; other site 1173025005670 D-loop; other site 1173025005671 H-loop/switch region; other site 1173025005672 NB-ARC domain; Region: NB-ARC; pfam00931 1173025005673 circadian clock protein KaiC; Reviewed; Region: PRK09302 1173025005674 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1173025005675 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1173025005676 Walker A motif; other site 1173025005677 Walker A motif; other site 1173025005678 ATP binding site [chemical binding]; other site 1173025005679 Walker B motif; other site 1173025005680 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1173025005681 Walker A motif; other site 1173025005682 ATP binding site [chemical binding]; other site 1173025005683 Walker B motif; other site 1173025005684 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1173025005685 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1173025005686 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1173025005687 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1173025005688 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1173025005689 Ligand Binding Site [chemical binding]; other site 1173025005690 Molecular Tunnel; other site 1173025005691 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1173025005692 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1173025005693 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1173025005694 catalytic residue [active] 1173025005695 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1173025005696 active site 1173025005697 metal binding site [ion binding]; metal-binding site 1173025005698 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1173025005699 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1173025005700 Ligand Binding Site [chemical binding]; other site 1173025005701 Molecular Tunnel; other site 1173025005702 AAA domain; Region: AAA_33; pfam13671 1173025005703 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1173025005704 active site 1173025005705 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1173025005706 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1173025005707 active site 1173025005708 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1173025005709 arsenical-resistance protein; Region: acr3; TIGR00832 1173025005710 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173025005711 dimerization interface [polypeptide binding]; other site 1173025005712 putative DNA binding site [nucleotide binding]; other site 1173025005713 putative Zn2+ binding site [ion binding]; other site 1173025005714 Protein of unknown function, DUF393; Region: DUF393; pfam04134 1173025005715 S-layer homology domain; Region: SLH; pfam00395 1173025005716 S-layer homology domain; Region: SLH; pfam00395 1173025005717 KWG Leptospira; Region: KWG; pfam07656 1173025005718 KWG Leptospira; Region: KWG; pfam07656 1173025005719 KWG Leptospira; Region: KWG; pfam07656 1173025005720 N2,N2-dimethylguanosine tRNA methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TRM1; COG1867 1173025005721 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1173025005722 S-adenosylmethionine binding site [chemical binding]; other site 1173025005723 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 1173025005724 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 1173025005725 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 1173025005726 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1173025005727 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1173025005728 putative NAD(P) binding site [chemical binding]; other site 1173025005729 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1173025005730 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1173025005731 active site 1173025005732 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 1173025005733 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 1173025005734 putative NAD(P) binding site [chemical binding]; other site 1173025005735 active site 1173025005736 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 1173025005737 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1173025005738 active site 1173025005739 putative substrate binding pocket [chemical binding]; other site 1173025005740 Protein kinase domain; Region: Pkinase; pfam00069 1173025005741 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173025005742 active site 1173025005743 ATP binding site [chemical binding]; other site 1173025005744 substrate binding site [chemical binding]; other site 1173025005745 activation loop (A-loop); other site 1173025005746 AAA ATPase domain; Region: AAA_16; pfam13191 1173025005747 Predicted ATPase [General function prediction only]; Region: COG3899 1173025005748 Walker A motif; other site 1173025005749 ATP binding site [chemical binding]; other site 1173025005750 Walker B motif; other site 1173025005751 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025005752 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025005753 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025005754 ATP binding site [chemical binding]; other site 1173025005755 Mg2+ binding site [ion binding]; other site 1173025005756 G-X-G motif; other site 1173025005757 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1173025005758 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173025005759 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1173025005760 protein binding site [polypeptide binding]; other site 1173025005761 FOG: CBS domain [General function prediction only]; Region: COG0517 1173025005762 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 1173025005763 FOG: CBS domain [General function prediction only]; Region: COG0517 1173025005764 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 1173025005765 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025005766 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025005767 PAS fold; Region: PAS_4; pfam08448 1173025005768 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025005769 PAS fold; Region: PAS_3; pfam08447 1173025005770 putative active site [active] 1173025005771 heme pocket [chemical binding]; other site 1173025005772 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173025005773 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025005774 putative active site [active] 1173025005775 heme pocket [chemical binding]; other site 1173025005776 PAS domain S-box; Region: sensory_box; TIGR00229 1173025005777 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025005778 putative active site [active] 1173025005779 heme pocket [chemical binding]; other site 1173025005780 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025005781 PAS fold; Region: PAS_3; pfam08447 1173025005782 putative active site [active] 1173025005783 heme pocket [chemical binding]; other site 1173025005784 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025005785 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025005786 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025005787 dimer interface [polypeptide binding]; other site 1173025005788 phosphorylation site [posttranslational modification] 1173025005789 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025005790 ATP binding site [chemical binding]; other site 1173025005791 Mg2+ binding site [ion binding]; other site 1173025005792 G-X-G motif; other site 1173025005793 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025005794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025005795 active site 1173025005796 phosphorylation site [posttranslational modification] 1173025005797 intermolecular recognition site; other site 1173025005798 dimerization interface [polypeptide binding]; other site 1173025005799 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025005800 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025005801 active site 1173025005802 phosphorylation site [posttranslational modification] 1173025005803 intermolecular recognition site; other site 1173025005804 dimerization interface [polypeptide binding]; other site 1173025005805 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025005806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025005807 active site 1173025005808 phosphorylation site [posttranslational modification] 1173025005809 intermolecular recognition site; other site 1173025005810 dimerization interface [polypeptide binding]; other site 1173025005811 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173025005812 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173025005813 metal binding site [ion binding]; metal-binding site 1173025005814 active site 1173025005815 I-site; other site 1173025005816 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025005817 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025005818 binding surface 1173025005819 TPR motif; other site 1173025005820 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025005821 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025005822 binding surface 1173025005823 TPR motif; other site 1173025005824 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025005825 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025005826 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025005827 binding surface 1173025005828 TPR motif; other site 1173025005829 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025005830 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025005831 binding surface 1173025005832 TPR motif; other site 1173025005833 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025005834 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025005835 TPR motif; other site 1173025005836 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025005837 binding surface 1173025005838 CHAT domain; Region: CHAT; pfam12770 1173025005839 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 1173025005840 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cd00590 1173025005841 CHAT domain; Region: CHAT; cl17868 1173025005842 CHAT domain; Region: CHAT; cl17868 1173025005843 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173025005844 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173025005845 structural tetrad; other site 1173025005846 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173025005847 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173025005848 structural tetrad; other site 1173025005849 WD40 repeats; Region: WD40; smart00320 1173025005850 CHAT domain; Region: CHAT; cl17868 1173025005851 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1173025005852 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173025005853 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173025005854 structural tetrad; other site 1173025005855 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173025005856 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173025005857 structural tetrad; other site 1173025005858 short chain dehydrogenase; Provisional; Region: PRK06701 1173025005859 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1173025005860 NAD binding site [chemical binding]; other site 1173025005861 metal binding site [ion binding]; metal-binding site 1173025005862 active site 1173025005863 Hemerythrin-like domain; Region: Hr-like; cd12108 1173025005864 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1173025005865 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1173025005866 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 1173025005867 putative hydrophobic ligand binding site [chemical binding]; other site 1173025005868 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1173025005869 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1173025005870 NAD binding site [chemical binding]; other site 1173025005871 catalytic Zn binding site [ion binding]; other site 1173025005872 structural Zn binding site [ion binding]; other site 1173025005873 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1173025005874 nudix motif; other site 1173025005875 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 1173025005876 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1173025005877 inhibitor-cofactor binding pocket; inhibition site 1173025005878 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173025005879 catalytic residue [active] 1173025005880 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1173025005881 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173025005882 catalytic residue [active] 1173025005883 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1173025005884 IucA / IucC family; Region: IucA_IucC; pfam04183 1173025005885 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1173025005886 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1173025005887 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1173025005888 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1173025005889 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 1173025005890 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1173025005891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1173025005892 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173025005893 putative substrate translocation pore; other site 1173025005894 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1173025005895 IucA / IucC family; Region: IucA_IucC; pfam04183 1173025005896 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1173025005897 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173025005898 DNA binding residues [nucleotide binding] 1173025005899 dimerization interface [polypeptide binding]; other site 1173025005900 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1173025005901 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 1173025005902 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1173025005903 conserved cys residue [active] 1173025005904 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173025005905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173025005906 S-adenosylmethionine binding site [chemical binding]; other site 1173025005907 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 1173025005908 CsbD-like; Region: CsbD; cl17424 1173025005909 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 1173025005910 PRC-barrel domain; Region: PRC; pfam05239 1173025005911 PRC-barrel domain; Region: PRC; pfam05239 1173025005912 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 1173025005913 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 1173025005914 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 1173025005915 tetramer interface [polypeptide binding]; other site 1173025005916 dimer interface [polypeptide binding]; other site 1173025005917 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 1173025005918 EamA-like transporter family; Region: EamA; cl17759 1173025005919 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 1173025005920 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173025005921 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173025005922 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 1173025005923 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173025005924 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1173025005925 dimer interface [polypeptide binding]; other site 1173025005926 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1173025005927 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1173025005928 SnoaL-like domain; Region: SnoaL_3; pfam13474 1173025005929 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1173025005930 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1173025005931 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1173025005932 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1173025005933 MoaE homodimer interface [polypeptide binding]; other site 1173025005934 MoaD interaction [polypeptide binding]; other site 1173025005935 active site residues [active] 1173025005936 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 1173025005937 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173025005938 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1173025005939 putative ADP-binding pocket [chemical binding]; other site 1173025005940 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173025005941 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173025005942 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173025005943 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173025005944 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173025005945 Walker A/P-loop; other site 1173025005946 ATP binding site [chemical binding]; other site 1173025005947 Q-loop/lid; other site 1173025005948 ABC transporter signature motif; other site 1173025005949 Walker B; other site 1173025005950 D-loop; other site 1173025005951 H-loop/switch region; other site 1173025005952 Phosphotransferase enzyme family; Region: APH; pfam01636 1173025005953 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1173025005954 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1173025005955 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1173025005956 tetramer interface [polypeptide binding]; other site 1173025005957 heme binding pocket [chemical binding]; other site 1173025005958 NADPH binding site [chemical binding]; other site 1173025005959 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173025005960 dimerization interface [polypeptide binding]; other site 1173025005961 putative DNA binding site [nucleotide binding]; other site 1173025005962 putative Zn2+ binding site [ion binding]; other site 1173025005963 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1173025005964 Active Sites [active] 1173025005965 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1173025005966 core domain interface [polypeptide binding]; other site 1173025005967 delta subunit interface [polypeptide binding]; other site 1173025005968 epsilon subunit interface [polypeptide binding]; other site 1173025005969 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1173025005970 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1173025005971 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1173025005972 Walker A motif; other site 1173025005973 ATP binding site [chemical binding]; other site 1173025005974 Walker B motif; other site 1173025005975 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1173025005976 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1173025005977 alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321 1173025005978 alternate F1F0 ATPase, F0 subunit C; Region: alt_F1F0_F0_C; TIGR03322 1173025005979 ATP synthase A chain; Region: ATP-synt_A; cl00413 1173025005980 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1173025005981 N-ATPase, AtpR subunit; Region: AtpR; pfam12966 1173025005982 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 1173025005983 F0F1 ATP synthase subunit epsilon; Validated; Region: PRK06228 1173025005984 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1173025005985 gamma subunit interface [polypeptide binding]; other site 1173025005986 epsilon subunit interface [polypeptide binding]; other site 1173025005987 LBP interface [polypeptide binding]; other site 1173025005988 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1173025005989 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1173025005990 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1173025005991 alpha subunit interaction interface [polypeptide binding]; other site 1173025005992 Walker A motif; other site 1173025005993 ATP binding site [chemical binding]; other site 1173025005994 Walker B motif; other site 1173025005995 inhibitor binding site; inhibition site 1173025005996 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1173025005997 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025005998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025005999 active site 1173025006000 phosphorylation site [posttranslational modification] 1173025006001 intermolecular recognition site; other site 1173025006002 dimerization interface [polypeptide binding]; other site 1173025006003 PAS domain S-box; Region: sensory_box; TIGR00229 1173025006004 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025006005 putative active site [active] 1173025006006 heme pocket [chemical binding]; other site 1173025006007 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173025006008 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173025006009 metal binding site [ion binding]; metal-binding site 1173025006010 active site 1173025006011 I-site; other site 1173025006012 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1173025006013 Cache domain; Region: Cache_1; pfam02743 1173025006014 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173025006015 dimerization interface [polypeptide binding]; other site 1173025006016 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025006017 dimer interface [polypeptide binding]; other site 1173025006018 phosphorylation site [posttranslational modification] 1173025006019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025006020 ATP binding site [chemical binding]; other site 1173025006021 Mg2+ binding site [ion binding]; other site 1173025006022 G-X-G motif; other site 1173025006023 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025006024 active site 1173025006025 phosphorylation site [posttranslational modification] 1173025006026 intermolecular recognition site; other site 1173025006027 dimerization interface [polypeptide binding]; other site 1173025006028 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1173025006029 putative active site [active] 1173025006030 LysE type translocator; Region: LysE; cl00565 1173025006031 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1173025006032 hydrophobic ligand binding site; other site 1173025006033 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173025006034 active site 1173025006035 DNA photolyase; Region: DNA_photolyase; pfam00875 1173025006036 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 1173025006037 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025006038 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025006039 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173025006040 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025006041 putative active site [active] 1173025006042 heme pocket [chemical binding]; other site 1173025006043 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025006044 putative active site [active] 1173025006045 heme pocket [chemical binding]; other site 1173025006046 PAS domain; Region: PAS; smart00091 1173025006047 PAS fold; Region: PAS_4; pfam08448 1173025006048 putative active site [active] 1173025006049 heme pocket [chemical binding]; other site 1173025006050 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1173025006051 Histidine kinase; Region: HisKA_3; pfam07730 1173025006052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025006053 ATP binding site [chemical binding]; other site 1173025006054 Mg2+ binding site [ion binding]; other site 1173025006055 G-X-G motif; other site 1173025006056 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173025006057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025006058 active site 1173025006059 phosphorylation site [posttranslational modification] 1173025006060 intermolecular recognition site; other site 1173025006061 dimerization interface [polypeptide binding]; other site 1173025006062 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173025006063 dimerization interface [polypeptide binding]; other site 1173025006064 DNA binding residues [nucleotide binding] 1173025006065 RDD family; Region: RDD; pfam06271 1173025006066 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1173025006067 Thioredoxin; Region: Thioredoxin_4; cl17273 1173025006068 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1173025006069 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1173025006070 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173025006071 NAD(P) binding site [chemical binding]; other site 1173025006072 active site 1173025006073 CAAX protease self-immunity; Region: Abi; pfam02517 1173025006074 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 1173025006075 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1173025006076 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1173025006077 NADP binding site [chemical binding]; other site 1173025006078 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1173025006079 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_like_4; cd06152 1173025006080 homotrimer interaction site [polypeptide binding]; other site 1173025006081 putative active site [active] 1173025006082 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173025006083 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1173025006084 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1173025006085 catalytic residues [active] 1173025006086 Predicted membrane protein [Function unknown]; Region: COG4325 1173025006087 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 1173025006088 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1173025006089 active site 1173025006090 catalytic residues [active] 1173025006091 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1173025006092 active site 1173025006093 catalytic residues [active] 1173025006094 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1173025006095 CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827 1173025006096 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 1173025006097 CRISPR-associated protein Csx17, subtype Dpsyc; Region: cas_csx17; TIGR04113 1173025006098 CRISPR/Cas system-associated protein Csx17; Region: Csx17_I-U; cd09767 1173025006099 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1173025006100 CRISPR-associated helicase Cas3, subtype Dpsyc; Region: cas3_GSU0051; TIGR02621 1173025006101 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1173025006102 dimerization interface [polypeptide binding]; other site 1173025006103 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1173025006104 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1173025006105 [2Fe-2S] cluster binding site [ion binding]; other site 1173025006106 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1173025006107 alpha subunit interface [polypeptide binding]; other site 1173025006108 active site 1173025006109 substrate binding site [chemical binding]; other site 1173025006110 Fe binding site [ion binding]; other site 1173025006111 Domain of Unknown Function with PDB structure (DUF3865); Region: DUF3865; pfam12981 1173025006112 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1173025006113 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1173025006114 FMN binding site [chemical binding]; other site 1173025006115 active site 1173025006116 catalytic residues [active] 1173025006117 substrate binding site [chemical binding]; other site 1173025006118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025006119 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173025006120 active site 1173025006121 phosphorylation site [posttranslational modification] 1173025006122 intermolecular recognition site; other site 1173025006123 dimerization interface [polypeptide binding]; other site 1173025006124 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025006125 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025006126 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025006127 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025006128 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025006129 dimer interface [polypeptide binding]; other site 1173025006130 phosphorylation site [posttranslational modification] 1173025006131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025006132 ATP binding site [chemical binding]; other site 1173025006133 Mg2+ binding site [ion binding]; other site 1173025006134 G-X-G motif; other site 1173025006135 CHASE3 domain; Region: CHASE3; pfam05227 1173025006136 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1173025006137 dimer interface [polypeptide binding]; other site 1173025006138 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1173025006139 putative CheW interface [polypeptide binding]; other site 1173025006140 CHASE3 domain; Region: CHASE3; pfam05227 1173025006141 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1173025006142 dimer interface [polypeptide binding]; other site 1173025006143 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1173025006144 putative CheW interface [polypeptide binding]; other site 1173025006145 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173025006146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025006147 active site 1173025006148 phosphorylation site [posttranslational modification] 1173025006149 intermolecular recognition site; other site 1173025006150 dimerization interface [polypeptide binding]; other site 1173025006151 CHASE domain; Region: CHASE; pfam03924 1173025006152 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025006153 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025006154 dimer interface [polypeptide binding]; other site 1173025006155 phosphorylation site [posttranslational modification] 1173025006156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025006157 ATP binding site [chemical binding]; other site 1173025006158 Mg2+ binding site [ion binding]; other site 1173025006159 G-X-G motif; other site 1173025006160 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1173025006161 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 1173025006162 folate binding site [chemical binding]; other site 1173025006163 NADP+ binding site [chemical binding]; other site 1173025006164 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025006165 GAF domain; Region: GAF; pfam01590 1173025006166 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025006167 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025006168 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025006169 dimer interface [polypeptide binding]; other site 1173025006170 phosphorylation site [posttranslational modification] 1173025006171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025006172 ATP binding site [chemical binding]; other site 1173025006173 Mg2+ binding site [ion binding]; other site 1173025006174 G-X-G motif; other site 1173025006175 PAS fold; Region: PAS_4; pfam08448 1173025006176 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025006177 putative active site [active] 1173025006178 heme pocket [chemical binding]; other site 1173025006179 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025006180 PAS fold; Region: PAS_3; pfam08447 1173025006181 putative active site [active] 1173025006182 heme pocket [chemical binding]; other site 1173025006183 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173025006184 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025006185 putative active site [active] 1173025006186 heme pocket [chemical binding]; other site 1173025006187 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025006188 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173025006189 putative active site [active] 1173025006190 heme pocket [chemical binding]; other site 1173025006191 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025006192 putative active site [active] 1173025006193 heme pocket [chemical binding]; other site 1173025006194 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025006195 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025006196 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173025006197 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173025006198 metal binding site [ion binding]; metal-binding site 1173025006199 active site 1173025006200 I-site; other site 1173025006201 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1173025006202 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1173025006203 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173025006204 Ligand Binding Site [chemical binding]; other site 1173025006205 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025006206 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025006207 active site 1173025006208 phosphorylation site [posttranslational modification] 1173025006209 intermolecular recognition site; other site 1173025006210 dimerization interface [polypeptide binding]; other site 1173025006211 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025006212 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025006213 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025006214 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025006215 dimer interface [polypeptide binding]; other site 1173025006216 phosphorylation site [posttranslational modification] 1173025006217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025006218 ATP binding site [chemical binding]; other site 1173025006219 Mg2+ binding site [ion binding]; other site 1173025006220 G-X-G motif; other site 1173025006221 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173025006222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025006223 active site 1173025006224 phosphorylation site [posttranslational modification] 1173025006225 intermolecular recognition site; other site 1173025006226 dimerization interface [polypeptide binding]; other site 1173025006227 PAS domain; Region: PAS_9; pfam13426 1173025006228 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025006229 putative active site [active] 1173025006230 heme pocket [chemical binding]; other site 1173025006231 PAS domain; Region: PAS_9; pfam13426 1173025006232 PAS fold; Region: PAS_4; pfam08448 1173025006233 PAS domain S-box; Region: sensory_box; TIGR00229 1173025006234 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025006235 putative active site [active] 1173025006236 heme pocket [chemical binding]; other site 1173025006237 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025006238 PAS fold; Region: PAS_3; pfam08447 1173025006239 putative active site [active] 1173025006240 heme pocket [chemical binding]; other site 1173025006241 PAS fold; Region: PAS_3; pfam08447 1173025006242 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025006243 putative active site [active] 1173025006244 heme pocket [chemical binding]; other site 1173025006245 PAS domain S-box; Region: sensory_box; TIGR00229 1173025006246 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025006247 putative active site [active] 1173025006248 heme pocket [chemical binding]; other site 1173025006249 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025006250 dimer interface [polypeptide binding]; other site 1173025006251 phosphorylation site [posttranslational modification] 1173025006252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025006253 ATP binding site [chemical binding]; other site 1173025006254 Mg2+ binding site [ion binding]; other site 1173025006255 G-X-G motif; other site 1173025006256 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 1173025006257 tetramer interface [polypeptide binding]; other site 1173025006258 dimer interface [polypeptide binding]; other site 1173025006259 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 1173025006260 tetramer interface [polypeptide binding]; other site 1173025006261 dimer interface [polypeptide binding]; other site 1173025006262 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173025006263 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025006264 active site 1173025006265 phosphorylation site [posttranslational modification] 1173025006266 intermolecular recognition site; other site 1173025006267 dimerization interface [polypeptide binding]; other site 1173025006268 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173025006269 DNA binding site [nucleotide binding] 1173025006270 Hpt domain; Region: Hpt; pfam01627 1173025006271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025006272 active site 1173025006273 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 1173025006274 phosphorylation site [posttranslational modification] 1173025006275 intermolecular recognition site; other site 1173025006276 dimerization interface [polypeptide binding]; other site 1173025006277 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025006278 active site 1173025006279 phosphorylation site [posttranslational modification] 1173025006280 intermolecular recognition site; other site 1173025006281 dimerization interface [polypeptide binding]; other site 1173025006282 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173025006283 metal binding site [ion binding]; metal-binding site 1173025006284 active site 1173025006285 I-site; other site 1173025006286 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1173025006287 dimer interface [polypeptide binding]; other site 1173025006288 FMN binding site [chemical binding]; other site 1173025006289 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 1173025006290 C factor cell-cell signaling protein; Provisional; Region: PRK09009 1173025006291 NADP binding site [chemical binding]; other site 1173025006292 homodimer interface [polypeptide binding]; other site 1173025006293 active site 1173025006294 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1173025006295 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1173025006296 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1173025006297 putative dimer interface [polypeptide binding]; other site 1173025006298 N-terminal domain interface [polypeptide binding]; other site 1173025006299 putative substrate binding pocket (H-site) [chemical binding]; other site 1173025006300 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1173025006301 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1173025006302 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1173025006303 TrkA-N domain; Region: TrkA_N; pfam02254 1173025006304 TrkA-C domain; Region: TrkA_C; pfam02080 1173025006305 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 1173025006306 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1173025006307 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1173025006308 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 1173025006309 methionine aminopeptidase; Provisional; Region: PRK08671 1173025006310 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1173025006311 active site 1173025006312 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 1173025006313 dimerization interface [polypeptide binding]; other site 1173025006314 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1173025006315 ATP binding site [chemical binding]; other site 1173025006316 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 1173025006317 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 1173025006318 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1173025006319 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1173025006320 putative catalytic cysteine [active] 1173025006321 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1173025006322 putative active site [active] 1173025006323 metal binding site [ion binding]; metal-binding site 1173025006324 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 1173025006325 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 1173025006326 putative active site [active] 1173025006327 putative FMN binding site [chemical binding]; other site 1173025006328 putative substrate binding site [chemical binding]; other site 1173025006329 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1173025006330 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1173025006331 dimer interface [polypeptide binding]; other site 1173025006332 PYR/PP interface [polypeptide binding]; other site 1173025006333 TPP binding site [chemical binding]; other site 1173025006334 substrate binding site [chemical binding]; other site 1173025006335 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1173025006336 Domain of unknown function; Region: EKR; smart00890 1173025006337 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1173025006338 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1173025006339 TPP-binding site [chemical binding]; other site 1173025006340 dimer interface [polypeptide binding]; other site 1173025006341 HupF/HypC family; Region: HupF_HypC; pfam01455 1173025006342 Acylphosphatase; Region: Acylphosphatase; pfam00708 1173025006343 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1173025006344 HypF finger; Region: zf-HYPF; pfam07503 1173025006345 HypF finger; Region: zf-HYPF; pfam07503 1173025006346 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1173025006347 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1173025006348 G1 box; other site 1173025006349 GTP/Mg2+ binding site [chemical binding]; other site 1173025006350 G2 box; other site 1173025006351 Switch I region; other site 1173025006352 G3 box; other site 1173025006353 Switch II region; other site 1173025006354 G4 box; other site 1173025006355 G5 box; other site 1173025006356 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1173025006357 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 1173025006358 CP12 domain; Region: CP12; pfam02672 1173025006359 Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066 1173025006360 nickel binding site [ion binding]; other site 1173025006361 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 1173025006362 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1173025006363 Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941 1173025006364 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1173025006365 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 1173025006366 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173025006367 catalytic loop [active] 1173025006368 iron binding site [ion binding]; other site 1173025006369 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1173025006370 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1173025006371 dimer interface [polypeptide binding]; other site 1173025006372 [2Fe-2S] cluster binding site [ion binding]; other site 1173025006373 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1173025006374 SLBB domain; Region: SLBB; pfam10531 1173025006375 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1173025006376 bidirectional hydrogenase complex protein HoxE; Reviewed; Region: PRK07571 1173025006377 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1173025006378 putative dimer interface [polypeptide binding]; other site 1173025006379 [2Fe-2S] cluster binding site [ion binding]; other site 1173025006380 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 1173025006381 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1173025006382 putative active site [active] 1173025006383 metal binding site [ion binding]; metal-binding site 1173025006384 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1173025006385 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 1173025006386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1173025006387 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1173025006388 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173025006389 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1173025006390 NAD(P) binding site [chemical binding]; other site 1173025006391 active site 1173025006392 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1173025006393 MarR family; Region: MarR; pfam01047 1173025006394 Predicted permease [General function prediction only]; Region: COG3329 1173025006395 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 1173025006396 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1173025006397 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1173025006398 Surface antigen; Region: Bac_surface_Ag; pfam01103 1173025006399 CHAT domain; Region: CHAT; cl17868 1173025006400 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 1173025006401 CHAT domain; Region: CHAT; cl17868 1173025006402 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1173025006403 CHASE2 domain; Region: CHASE2; pfam05226 1173025006404 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 1173025006405 RNA polymerase sigma factor; Provisional; Region: PRK11924 1173025006406 Family description; Region: VCBS; pfam13517 1173025006407 Family description; Region: VCBS; pfam13517 1173025006408 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1173025006409 Peptidase family M23; Region: Peptidase_M23; pfam01551 1173025006410 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 1173025006411 PAS fold; Region: PAS_4; pfam08448 1173025006412 PAS domain S-box; Region: sensory_box; TIGR00229 1173025006413 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025006414 putative active site [active] 1173025006415 heme pocket [chemical binding]; other site 1173025006416 PAS domain; Region: PAS_9; pfam13426 1173025006417 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173025006418 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025006419 putative active site [active] 1173025006420 heme pocket [chemical binding]; other site 1173025006421 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025006422 putative active site [active] 1173025006423 heme pocket [chemical binding]; other site 1173025006424 PAS domain S-box; Region: sensory_box; TIGR00229 1173025006425 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025006426 putative active site [active] 1173025006427 heme pocket [chemical binding]; other site 1173025006428 PAS fold; Region: PAS_3; pfam08447 1173025006429 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1173025006430 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025006431 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025006432 dimer interface [polypeptide binding]; other site 1173025006433 phosphorylation site [posttranslational modification] 1173025006434 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025006435 ATP binding site [chemical binding]; other site 1173025006436 Mg2+ binding site [ion binding]; other site 1173025006437 G-X-G motif; other site 1173025006438 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173025006439 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173025006440 DNA binding residues [nucleotide binding] 1173025006441 dimerization interface [polypeptide binding]; other site 1173025006442 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1173025006443 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 1173025006444 putative N-terminal domain interface [polypeptide binding]; other site 1173025006445 Amino acid permease; Region: AA_permease_2; pfam13520 1173025006446 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1173025006447 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025006448 putative active site [active] 1173025006449 heme pocket [chemical binding]; other site 1173025006450 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025006451 dimer interface [polypeptide binding]; other site 1173025006452 phosphorylation site [posttranslational modification] 1173025006453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025006454 ATP binding site [chemical binding]; other site 1173025006455 Mg2+ binding site [ion binding]; other site 1173025006456 G-X-G motif; other site 1173025006457 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 1173025006458 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1173025006459 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173025006460 homodimer interface [polypeptide binding]; other site 1173025006461 catalytic residue [active] 1173025006462 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1173025006463 active site 1173025006464 catalytic site [active] 1173025006465 substrate binding site [chemical binding]; other site 1173025006466 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173025006467 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1173025006468 Walker A motif; other site 1173025006469 ATP binding site [chemical binding]; other site 1173025006470 TROVE domain; Region: TROVE; pfam05731 1173025006471 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 1173025006472 diiron binding motif [ion binding]; other site 1173025006473 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1173025006474 heme binding pocket [chemical binding]; other site 1173025006475 heme ligand [chemical binding]; other site 1173025006476 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1173025006477 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173025006478 FeS/SAM binding site; other site 1173025006479 HemN C-terminal domain; Region: HemN_C; pfam06969 1173025006480 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1173025006481 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1173025006482 Di-iron ligands [ion binding]; other site 1173025006483 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1173025006484 putative metal binding site; other site 1173025006485 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1173025006486 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025006487 binding surface 1173025006488 TPR motif; other site 1173025006489 TPR repeat; Region: TPR_11; pfam13414 1173025006490 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1173025006491 Fasciclin domain; Region: Fasciclin; pfam02469 1173025006492 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1173025006493 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1173025006494 C-terminal domain interface [polypeptide binding]; other site 1173025006495 GSH binding site (G-site) [chemical binding]; other site 1173025006496 dimer interface [polypeptide binding]; other site 1173025006497 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1173025006498 N-terminal domain interface [polypeptide binding]; other site 1173025006499 HAS barrel domain; Region: HAS-barrel; pfam09378 1173025006500 HerA helicase [Replication, recombination, and repair]; Region: COG0433 1173025006501 Domain of unknown function DUF87; Region: DUF87; pfam01935 1173025006502 RNA polymerase sigma factor; Validated; Region: PRK05949 1173025006503 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1173025006504 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173025006505 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1173025006506 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173025006507 DNA binding residues [nucleotide binding] 1173025006508 NACHT domain; Region: NACHT; pfam05729 1173025006509 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173025006510 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025006511 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025006512 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1173025006513 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1173025006514 active site residue [active] 1173025006515 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1173025006516 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 1173025006517 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1173025006518 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1173025006519 glycogen synthase; Provisional; Region: glgA; PRK00654 1173025006520 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1173025006521 ADP-binding pocket [chemical binding]; other site 1173025006522 homodimer interface [polypeptide binding]; other site 1173025006523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1173025006524 active site 1173025006525 phosphorylation site [posttranslational modification] 1173025006526 intermolecular recognition site; other site 1173025006527 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025006528 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025006529 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025006530 dimer interface [polypeptide binding]; other site 1173025006531 phosphorylation site [posttranslational modification] 1173025006532 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025006533 ATP binding site [chemical binding]; other site 1173025006534 Mg2+ binding site [ion binding]; other site 1173025006535 G-X-G motif; other site 1173025006536 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173025006537 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025006538 active site 1173025006539 phosphorylation site [posttranslational modification] 1173025006540 intermolecular recognition site; other site 1173025006541 dimerization interface [polypeptide binding]; other site 1173025006542 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173025006543 DNA binding site [nucleotide binding] 1173025006544 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173025006545 putative binding surface; other site 1173025006546 active site 1173025006547 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025006548 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025006549 active site 1173025006550 phosphorylation site [posttranslational modification] 1173025006551 intermolecular recognition site; other site 1173025006552 dimerization interface [polypeptide binding]; other site 1173025006553 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025006554 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025006555 active site 1173025006556 phosphorylation site [posttranslational modification] 1173025006557 intermolecular recognition site; other site 1173025006558 dimerization interface [polypeptide binding]; other site 1173025006559 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025006560 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025006561 active site 1173025006562 phosphorylation site [posttranslational modification] 1173025006563 intermolecular recognition site; other site 1173025006564 dimerization interface [polypeptide binding]; other site 1173025006565 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025006566 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025006567 active site 1173025006568 phosphorylation site [posttranslational modification] 1173025006569 intermolecular recognition site; other site 1173025006570 dimerization interface [polypeptide binding]; other site 1173025006571 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025006572 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025006573 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025006574 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025006575 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025006576 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025006577 dimer interface [polypeptide binding]; other site 1173025006578 phosphorylation site [posttranslational modification] 1173025006579 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025006580 ATP binding site [chemical binding]; other site 1173025006581 Mg2+ binding site [ion binding]; other site 1173025006582 G-X-G motif; other site 1173025006583 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1173025006584 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1173025006585 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1173025006586 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173025006587 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1173025006588 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173025006589 motif II; other site 1173025006590 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1173025006591 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1173025006592 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025006593 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025006594 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173025006595 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173025006596 metal binding site [ion binding]; metal-binding site 1173025006597 active site 1173025006598 I-site; other site 1173025006599 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173025006600 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173025006601 metal binding site [ion binding]; metal-binding site 1173025006602 active site 1173025006603 I-site; other site 1173025006604 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1173025006605 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 1173025006606 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 1173025006607 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173025006608 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 1173025006609 putative ADP-binding pocket [chemical binding]; other site 1173025006610 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173025006611 TPR motif; other site 1173025006612 binding surface 1173025006613 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 1173025006614 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025006615 GAF domain; Region: GAF_3; pfam13492 1173025006616 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025006617 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025006618 dimer interface [polypeptide binding]; other site 1173025006619 phosphorylation site [posttranslational modification] 1173025006620 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025006621 ATP binding site [chemical binding]; other site 1173025006622 Mg2+ binding site [ion binding]; other site 1173025006623 G-X-G motif; other site 1173025006624 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025006625 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025006626 active site 1173025006627 phosphorylation site [posttranslational modification] 1173025006628 intermolecular recognition site; other site 1173025006629 dimerization interface [polypeptide binding]; other site 1173025006630 PAS fold; Region: PAS_4; pfam08448 1173025006631 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025006632 putative active site [active] 1173025006633 heme pocket [chemical binding]; other site 1173025006634 PAS domain; Region: PAS_9; pfam13426 1173025006635 PAS domain; Region: PAS_9; pfam13426 1173025006636 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1173025006637 Histidine kinase; Region: HisKA_2; pfam07568 1173025006638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025006639 ATP binding site [chemical binding]; other site 1173025006640 Mg2+ binding site [ion binding]; other site 1173025006641 G-X-G motif; other site 1173025006642 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173025006643 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025006644 active site 1173025006645 phosphorylation site [posttranslational modification] 1173025006646 intermolecular recognition site; other site 1173025006647 dimerization interface [polypeptide binding]; other site 1173025006648 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025006649 putative active site [active] 1173025006650 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025006651 heme pocket [chemical binding]; other site 1173025006652 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025006653 dimer interface [polypeptide binding]; other site 1173025006654 phosphorylation site [posttranslational modification] 1173025006655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025006656 ATP binding site [chemical binding]; other site 1173025006657 Mg2+ binding site [ion binding]; other site 1173025006658 G-X-G motif; other site 1173025006659 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1173025006660 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1173025006661 proposed catalytic triad [active] 1173025006662 conserved cys residue [active] 1173025006663 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 1173025006664 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1173025006665 putative active site pocket [active] 1173025006666 dimerization interface [polypeptide binding]; other site 1173025006667 putative catalytic residue [active] 1173025006668 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025006669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025006670 active site 1173025006671 phosphorylation site [posttranslational modification] 1173025006672 intermolecular recognition site; other site 1173025006673 dimerization interface [polypeptide binding]; other site 1173025006674 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025006675 PAS fold; Region: PAS_3; pfam08447 1173025006676 putative active site [active] 1173025006677 heme pocket [chemical binding]; other site 1173025006678 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025006679 PAS fold; Region: PAS_3; pfam08447 1173025006680 putative active site [active] 1173025006681 heme pocket [chemical binding]; other site 1173025006682 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025006683 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025006684 dimer interface [polypeptide binding]; other site 1173025006685 phosphorylation site [posttranslational modification] 1173025006686 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025006687 ATP binding site [chemical binding]; other site 1173025006688 Mg2+ binding site [ion binding]; other site 1173025006689 G-X-G motif; other site 1173025006690 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173025006691 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025006692 active site 1173025006693 phosphorylation site [posttranslational modification] 1173025006694 intermolecular recognition site; other site 1173025006695 dimerization interface [polypeptide binding]; other site 1173025006696 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 1173025006697 CheB methylesterase; Region: CheB_methylest; pfam01339 1173025006698 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1173025006699 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1173025006700 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1173025006701 CHASE3 domain; Region: CHASE3; cl05000 1173025006702 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173025006703 dimerization interface [polypeptide binding]; other site 1173025006704 GAF domain; Region: GAF_2; pfam13185 1173025006705 GAF domain; Region: GAF; pfam01590 1173025006706 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025006707 dimer interface [polypeptide binding]; other site 1173025006708 phosphorylation site [posttranslational modification] 1173025006709 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025006710 ATP binding site [chemical binding]; other site 1173025006711 Mg2+ binding site [ion binding]; other site 1173025006712 G-X-G motif; other site 1173025006713 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025006714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025006715 active site 1173025006716 phosphorylation site [posttranslational modification] 1173025006717 intermolecular recognition site; other site 1173025006718 dimerization interface [polypeptide binding]; other site 1173025006719 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025006720 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025006721 active site 1173025006722 phosphorylation site [posttranslational modification] 1173025006723 intermolecular recognition site; other site 1173025006724 dimerization interface [polypeptide binding]; other site 1173025006725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025006726 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025006727 active site 1173025006728 phosphorylation site [posttranslational modification] 1173025006729 intermolecular recognition site; other site 1173025006730 dimerization interface [polypeptide binding]; other site 1173025006731 CHASE3 domain; Region: CHASE3; pfam05227 1173025006732 GAF domain; Region: GAF_2; pfam13185 1173025006733 GAF domain; Region: GAF_3; pfam13492 1173025006734 PAS domain S-box; Region: sensory_box; TIGR00229 1173025006735 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025006736 putative active site [active] 1173025006737 heme pocket [chemical binding]; other site 1173025006738 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025006739 dimer interface [polypeptide binding]; other site 1173025006740 phosphorylation site [posttranslational modification] 1173025006741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025006742 ATP binding site [chemical binding]; other site 1173025006743 Mg2+ binding site [ion binding]; other site 1173025006744 G-X-G motif; other site 1173025006745 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1173025006746 amphipathic channel; other site 1173025006747 Asn-Pro-Ala signature motifs; other site 1173025006748 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1173025006749 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1173025006750 siderophore binding site; other site 1173025006751 AMIN domain; Region: AMIN; pfam11741 1173025006752 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1173025006753 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173025006754 N-terminal plug; other site 1173025006755 ligand-binding site [chemical binding]; other site 1173025006756 GAF domain; Region: GAF_2; pfam13185 1173025006757 GAF domain; Region: GAF_3; pfam13492 1173025006758 PAS domain S-box; Region: sensory_box; TIGR00229 1173025006759 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025006760 putative active site [active] 1173025006761 heme pocket [chemical binding]; other site 1173025006762 PAS domain S-box; Region: sensory_box; TIGR00229 1173025006763 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025006764 putative active site [active] 1173025006765 heme pocket [chemical binding]; other site 1173025006766 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025006767 PAS fold; Region: PAS_3; pfam08447 1173025006768 putative active site [active] 1173025006769 heme pocket [chemical binding]; other site 1173025006770 PAS domain S-box; Region: sensory_box; TIGR00229 1173025006771 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025006772 putative active site [active] 1173025006773 heme pocket [chemical binding]; other site 1173025006774 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1173025006775 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173025006776 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025006777 putative active site [active] 1173025006778 heme pocket [chemical binding]; other site 1173025006779 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025006780 dimer interface [polypeptide binding]; other site 1173025006781 phosphorylation site [posttranslational modification] 1173025006782 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025006783 ATP binding site [chemical binding]; other site 1173025006784 Mg2+ binding site [ion binding]; other site 1173025006785 G-X-G motif; other site 1173025006786 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173025006787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025006788 active site 1173025006789 phosphorylation site [posttranslational modification] 1173025006790 intermolecular recognition site; other site 1173025006791 dimerization interface [polypeptide binding]; other site 1173025006792 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 1173025006793 ArsC family; Region: ArsC; pfam03960 1173025006794 catalytic residue [active] 1173025006795 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1173025006796 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1173025006797 proline aminopeptidase P II; Provisional; Region: PRK10879 1173025006798 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1173025006799 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1173025006800 active site 1173025006801 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1173025006802 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 1173025006803 BON domain; Region: BON; cl02771 1173025006804 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1173025006805 Chain length determinant protein; Region: Wzz; pfam02706 1173025006806 Chain length determinant protein; Region: Wzz; cl15801 1173025006807 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1173025006808 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173025006809 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1173025006810 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 1173025006811 SLBB domain; Region: SLBB; pfam10531 1173025006812 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1173025006813 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1173025006814 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173025006815 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1173025006816 active site 1173025006817 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1173025006818 O-Antigen ligase; Region: Wzy_C; pfam04932 1173025006819 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173025006820 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1173025006821 putative ADP-binding pocket [chemical binding]; other site 1173025006822 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1173025006823 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1173025006824 active site 1173025006825 CoA binding site [chemical binding]; other site 1173025006826 substrate binding site [chemical binding]; other site 1173025006827 trimer interface [polypeptide binding]; other site 1173025006828 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173025006829 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1173025006830 active site 1173025006831 Protein of unknown function (DUF563); Region: DUF563; pfam04577 1173025006832 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1173025006833 BNR repeat-like domain; Region: BNR_2; pfam13088 1173025006834 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1173025006835 metal binding site [ion binding]; metal-binding site 1173025006836 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1173025006837 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1173025006838 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1173025006839 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1173025006840 FMN binding site [chemical binding]; other site 1173025006841 substrate binding site [chemical binding]; other site 1173025006842 putative catalytic residue [active] 1173025006843 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173025006844 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025006845 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025006846 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025006847 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025006848 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 1173025006849 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1173025006850 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 1173025006851 conserved cys residue [active] 1173025006852 MEKHLA domain; Region: MEKHLA; pfam08670 1173025006853 hydrolase, alpha/beta fold family protein; Region: PLN02824 1173025006854 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173025006855 cyanate hydratase; Validated; Region: PRK02866 1173025006856 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 1173025006857 oligomer interface [polypeptide binding]; other site 1173025006858 active site 1173025006859 probable polyamine oxidase; Region: PLN02268 1173025006860 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173025006861 translation initiation factor IF-3; Region: infC; TIGR00168 1173025006862 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1173025006863 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1173025006864 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 1173025006865 Right handed beta helix region; Region: Beta_helix; pfam13229 1173025006866 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 1173025006867 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1173025006868 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025006869 binding surface 1173025006870 TPR motif; other site 1173025006871 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025006872 binding surface 1173025006873 TPR motif; other site 1173025006874 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1173025006875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173025006876 dimer interface [polypeptide binding]; other site 1173025006877 conserved gate region; other site 1173025006878 putative PBP binding loops; other site 1173025006879 ABC-ATPase subunit interface; other site 1173025006880 sulfate transport protein; Provisional; Region: cysT; CHL00187 1173025006881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173025006882 dimer interface [polypeptide binding]; other site 1173025006883 conserved gate region; other site 1173025006884 putative PBP binding loops; other site 1173025006885 ABC-ATPase subunit interface; other site 1173025006886 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1173025006887 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1173025006888 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1173025006889 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 1173025006890 Chromate transporter; Region: Chromate_transp; pfam02417 1173025006891 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173025006892 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1173025006893 putative switch regulator; other site 1173025006894 non-specific DNA interactions [nucleotide binding]; other site 1173025006895 DNA binding site [nucleotide binding] 1173025006896 sequence specific DNA binding site [nucleotide binding]; other site 1173025006897 putative cAMP binding site [chemical binding]; other site 1173025006898 NIL domain; Region: NIL; pfam09383 1173025006899 Predicted transcriptional regulator [Transcription]; Region: COG1959 1173025006900 Transcriptional regulator; Region: Rrf2; pfam02082 1173025006901 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1173025006902 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1173025006903 iron-sulfur cluster [ion binding]; other site 1173025006904 [2Fe-2S] cluster binding site [ion binding]; other site 1173025006905 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173025006906 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173025006907 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1173025006908 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1173025006909 nucleotide binding region [chemical binding]; other site 1173025006910 ATP-binding site [chemical binding]; other site 1173025006911 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1173025006912 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1173025006913 substrate binding pocket [chemical binding]; other site 1173025006914 membrane-bound complex binding site; other site 1173025006915 hinge residues; other site 1173025006916 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025006917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025006918 active site 1173025006919 phosphorylation site [posttranslational modification] 1173025006920 intermolecular recognition site; other site 1173025006921 dimerization interface [polypeptide binding]; other site 1173025006922 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025006923 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025006924 ATP binding site [chemical binding]; other site 1173025006925 Mg2+ binding site [ion binding]; other site 1173025006926 G-X-G motif; other site 1173025006927 Cache domain; Region: Cache_1; pfam02743 1173025006928 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025006929 dimer interface [polypeptide binding]; other site 1173025006930 phosphorylation site [posttranslational modification] 1173025006931 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025006932 ATP binding site [chemical binding]; other site 1173025006933 Mg2+ binding site [ion binding]; other site 1173025006934 G-X-G motif; other site 1173025006935 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025006936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025006937 active site 1173025006938 phosphorylation site [posttranslational modification] 1173025006939 intermolecular recognition site; other site 1173025006940 dimerization interface [polypeptide binding]; other site 1173025006941 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1173025006942 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1173025006943 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173025006944 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1173025006945 MG2 domain; Region: A2M_N; pfam01835 1173025006946 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173025006947 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025006948 active site 1173025006949 phosphorylation site [posttranslational modification] 1173025006950 intermolecular recognition site; other site 1173025006951 dimerization interface [polypeptide binding]; other site 1173025006952 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173025006953 DNA binding site [nucleotide binding] 1173025006954 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025006955 dimer interface [polypeptide binding]; other site 1173025006956 phosphorylation site [posttranslational modification] 1173025006957 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025006958 ATP binding site [chemical binding]; other site 1173025006959 Mg2+ binding site [ion binding]; other site 1173025006960 G-X-G motif; other site 1173025006961 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1173025006962 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 1173025006963 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1173025006964 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1173025006965 putative acyl-acceptor binding pocket; other site 1173025006966 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1173025006967 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025006968 binding surface 1173025006969 TPR motif; other site 1173025006970 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025006971 binding surface 1173025006972 TPR motif; other site 1173025006973 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025006974 binding surface 1173025006975 TPR motif; other site 1173025006976 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1173025006977 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173025006978 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025006979 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025006980 TPR motif; other site 1173025006981 binding surface 1173025006982 TPR repeat; Region: TPR_11; pfam13414 1173025006983 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025006984 binding surface 1173025006985 TPR motif; other site 1173025006986 TPR repeat; Region: TPR_11; pfam13414 1173025006987 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025006988 TPR repeat; Region: TPR_11; pfam13414 1173025006989 binding surface 1173025006990 TPR motif; other site 1173025006991 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 1173025006992 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1173025006993 SnoaL-like domain; Region: SnoaL_2; pfam12680 1173025006994 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1173025006995 cytosine deaminase; Provisional; Region: PRK09230 1173025006996 active site 1173025006997 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1173025006998 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 1173025006999 Hexamer interface [polypeptide binding]; other site 1173025007000 Hexagonal pore residue; other site 1173025007001 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1173025007002 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 1173025007003 Hexamer interface [polypeptide binding]; other site 1173025007004 Hexagonal pore residue; other site 1173025007005 heterocyst differentiation control protein; Reviewed; Region: hetR; PRK13245 1173025007006 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173025007007 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1173025007008 Probable transposase; Region: OrfB_IS605; pfam01385 1173025007009 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173025007010 6-phosphofructokinase; Provisional; Region: PRK14071 1173025007011 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1173025007012 active site 1173025007013 ADP/pyrophosphate binding site [chemical binding]; other site 1173025007014 dimerization interface [polypeptide binding]; other site 1173025007015 allosteric effector site; other site 1173025007016 fructose-1,6-bisphosphate binding site; other site 1173025007017 GTPase Era; Reviewed; Region: era; PRK00089 1173025007018 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1173025007019 G1 box; other site 1173025007020 GTP/Mg2+ binding site [chemical binding]; other site 1173025007021 Switch I region; other site 1173025007022 G2 box; other site 1173025007023 Switch II region; other site 1173025007024 G3 box; other site 1173025007025 G4 box; other site 1173025007026 G5 box; other site 1173025007027 KH domain; Region: KH_2; pfam07650 1173025007028 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1173025007029 active site clefts [active] 1173025007030 zinc binding site [ion binding]; other site 1173025007031 dimer interface [polypeptide binding]; other site 1173025007032 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173025007033 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173025007034 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1173025007035 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1173025007036 active site 1173025007037 dimer interface [polypeptide binding]; other site 1173025007038 metal binding site [ion binding]; metal-binding site 1173025007039 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 1173025007040 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 1173025007041 putative active site [active] 1173025007042 putative NTP binding site [chemical binding]; other site 1173025007043 putative nucleic acid binding site [nucleotide binding]; other site 1173025007044 FOG: CBS domain [General function prediction only]; Region: COG0517 1173025007045 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1173025007046 FOG: CBS domain [General function prediction only]; Region: COG0517 1173025007047 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 1173025007048 PAS domain S-box; Region: sensory_box; TIGR00229 1173025007049 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025007050 putative active site [active] 1173025007051 heme pocket [chemical binding]; other site 1173025007052 PAS fold; Region: PAS_4; pfam08448 1173025007053 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1173025007054 putative active site [active] 1173025007055 heme pocket [chemical binding]; other site 1173025007056 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025007057 PAS domain; Region: PAS_9; pfam13426 1173025007058 putative active site [active] 1173025007059 heme pocket [chemical binding]; other site 1173025007060 PAS fold; Region: PAS_4; pfam08448 1173025007061 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025007062 putative active site [active] 1173025007063 heme pocket [chemical binding]; other site 1173025007064 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025007065 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025007066 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025007067 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025007068 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025007069 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025007070 dimer interface [polypeptide binding]; other site 1173025007071 phosphorylation site [posttranslational modification] 1173025007072 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025007073 ATP binding site [chemical binding]; other site 1173025007074 Mg2+ binding site [ion binding]; other site 1173025007075 G-X-G motif; other site 1173025007076 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173025007077 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1173025007078 Peptidase family U32; Region: Peptidase_U32; pfam01136 1173025007079 Collagenase; Region: DUF3656; pfam12392 1173025007080 Peptidase family U32; Region: Peptidase_U32; cl03113 1173025007081 Stage II sporulation protein; Region: SpoIID; pfam08486 1173025007082 Predicted metal-binding protein [Function unknown]; Region: COG5469 1173025007083 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025007084 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025007085 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1173025007086 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1173025007087 Walker A/P-loop; other site 1173025007088 ATP binding site [chemical binding]; other site 1173025007089 Q-loop/lid; other site 1173025007090 ABC transporter signature motif; other site 1173025007091 Walker B; other site 1173025007092 D-loop; other site 1173025007093 H-loop/switch region; other site 1173025007094 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 1173025007095 PDGLE domain; Region: PDGLE; pfam13190 1173025007096 cobalt transport protein CbiM; Validated; Region: PRK06265 1173025007097 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1173025007098 Predicted integral membrane protein [Function unknown]; Region: COG5500 1173025007099 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1173025007100 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1173025007101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1173025007102 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1173025007103 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1173025007104 putative acyl-acceptor binding pocket; other site 1173025007105 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173025007106 dimerization interface [polypeptide binding]; other site 1173025007107 putative DNA binding site [nucleotide binding]; other site 1173025007108 putative Zn2+ binding site [ion binding]; other site 1173025007109 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1173025007110 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1173025007111 FMN binding site [chemical binding]; other site 1173025007112 active site 1173025007113 substrate binding site [chemical binding]; other site 1173025007114 catalytic residue [active] 1173025007115 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1173025007116 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1173025007117 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1173025007118 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173025007119 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1173025007120 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173025007121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025007122 active site 1173025007123 phosphorylation site [posttranslational modification] 1173025007124 intermolecular recognition site; other site 1173025007125 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173025007126 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025007127 putative active site [active] 1173025007128 heme pocket [chemical binding]; other site 1173025007129 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025007130 dimer interface [polypeptide binding]; other site 1173025007131 phosphorylation site [posttranslational modification] 1173025007132 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025007133 ATP binding site [chemical binding]; other site 1173025007134 Mg2+ binding site [ion binding]; other site 1173025007135 G-X-G motif; other site 1173025007136 GH3 auxin-responsive promoter; Region: GH3; pfam03321 1173025007137 Predicted membrane protein [Function unknown]; Region: COG1238 1173025007138 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1173025007139 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173025007140 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173025007141 active site 1173025007142 ATP binding site [chemical binding]; other site 1173025007143 substrate binding site [chemical binding]; other site 1173025007144 activation loop (A-loop); other site 1173025007145 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1173025007146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173025007147 putative substrate translocation pore; other site 1173025007148 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173025007149 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025007150 Tetratricopeptide repeat; Region: TPR_1; pfam00515 1173025007151 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025007152 binding surface 1173025007153 TPR motif; other site 1173025007154 TPR repeat; Region: TPR_11; pfam13414 1173025007155 PAS fold; Region: PAS_4; pfam08448 1173025007156 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025007157 putative active site [active] 1173025007158 heme pocket [chemical binding]; other site 1173025007159 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025007160 dimer interface [polypeptide binding]; other site 1173025007161 phosphorylation site [posttranslational modification] 1173025007162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025007163 ATP binding site [chemical binding]; other site 1173025007164 Mg2+ binding site [ion binding]; other site 1173025007165 G-X-G motif; other site 1173025007166 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1173025007167 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173025007168 substrate binding pocket [chemical binding]; other site 1173025007169 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1173025007170 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1173025007171 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1173025007172 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1173025007173 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173025007174 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1173025007175 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1173025007176 putative trimer interface [polypeptide binding]; other site 1173025007177 putative CoA binding site [chemical binding]; other site 1173025007178 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1173025007179 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1173025007180 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1173025007181 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1173025007182 [2Fe-2S] cluster binding site [ion binding]; other site 1173025007183 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1173025007184 hydrophobic ligand binding site; other site 1173025007185 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173025007186 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173025007187 catalytic loop [active] 1173025007188 iron binding site [ion binding]; other site 1173025007189 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1173025007190 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1173025007191 [2Fe-2S] cluster binding site [ion binding]; other site 1173025007192 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1173025007193 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1173025007194 [2Fe-2S] cluster binding site [ion binding]; other site 1173025007195 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1173025007196 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1173025007197 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 1173025007198 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 1173025007199 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1173025007200 RibD C-terminal domain; Region: RibD_C; cl17279 1173025007201 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1173025007202 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1173025007203 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1173025007204 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025007205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025007206 active site 1173025007207 phosphorylation site [posttranslational modification] 1173025007208 intermolecular recognition site; other site 1173025007209 dimerization interface [polypeptide binding]; other site 1173025007210 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025007211 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1173025007212 dimer interface [polypeptide binding]; other site 1173025007213 phosphorylation site [posttranslational modification] 1173025007214 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025007215 ATP binding site [chemical binding]; other site 1173025007216 Mg2+ binding site [ion binding]; other site 1173025007217 G-X-G motif; other site 1173025007218 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 1173025007219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025007220 active site 1173025007221 phosphorylation site [posttranslational modification] 1173025007222 intermolecular recognition site; other site 1173025007223 CheB methylesterase; Region: CheB_methylest; pfam01339 1173025007224 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173025007225 putative binding surface; other site 1173025007226 active site 1173025007227 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1173025007228 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1173025007229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025007230 ATP binding site [chemical binding]; other site 1173025007231 Mg2+ binding site [ion binding]; other site 1173025007232 G-X-G motif; other site 1173025007233 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1173025007234 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025007235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025007236 active site 1173025007237 phosphorylation site [posttranslational modification] 1173025007238 intermolecular recognition site; other site 1173025007239 dimerization interface [polypeptide binding]; other site 1173025007240 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1173025007241 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173025007242 dimerization interface [polypeptide binding]; other site 1173025007243 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1173025007244 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1173025007245 dimer interface [polypeptide binding]; other site 1173025007246 putative CheW interface [polypeptide binding]; other site 1173025007247 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1173025007248 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1173025007249 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1173025007250 TrkA-N domain; Region: TrkA_N; pfam02254 1173025007251 TrkA-C domain; Region: TrkA_C; pfam02080 1173025007252 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1173025007253 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1173025007254 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025007255 binding surface 1173025007256 TPR repeat; Region: TPR_11; pfam13414 1173025007257 TPR motif; other site 1173025007258 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 1173025007259 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1173025007260 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 1173025007261 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173025007262 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173025007263 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1173025007264 Walker A/P-loop; other site 1173025007265 ATP binding site [chemical binding]; other site 1173025007266 Q-loop/lid; other site 1173025007267 ABC transporter signature motif; other site 1173025007268 Walker B; other site 1173025007269 D-loop; other site 1173025007270 H-loop/switch region; other site 1173025007271 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173025007272 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173025007273 active site 1173025007274 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173025007275 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173025007276 Cupin domain; Region: Cupin_2; cl17218 1173025007277 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173025007278 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 1173025007279 putative ADP-binding pocket [chemical binding]; other site 1173025007280 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1173025007281 Chain length determinant protein; Region: Wzz; cl15801 1173025007282 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1173025007283 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173025007284 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1173025007285 colanic acid exporter; Provisional; Region: PRK10459 1173025007286 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1173025007287 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1173025007288 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173025007289 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173025007290 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173025007291 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173025007292 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 1173025007293 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173025007294 active site 1173025007295 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173025007296 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173025007297 active site 1173025007298 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1173025007299 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1173025007300 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173025007301 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173025007302 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173025007303 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1173025007304 putative ADP-binding pocket [chemical binding]; other site 1173025007305 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 1173025007306 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1173025007307 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1173025007308 active site 1173025007309 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1173025007310 HNH endonuclease; Region: HNH_5; pfam14279 1173025007311 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1173025007312 CoA binding domain; Region: CoA_binding_2; pfam13380 1173025007313 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1173025007314 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1173025007315 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1173025007316 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1173025007317 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 1173025007318 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 1173025007319 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173025007320 FeS/SAM binding site; other site 1173025007321 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 1173025007322 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1173025007323 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1173025007324 Leucine-rich repeats; other site 1173025007325 Leucine rich repeat; Region: LRR_8; pfam13855 1173025007326 Substrate binding site [chemical binding]; other site 1173025007327 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1173025007328 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1173025007329 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1173025007330 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1173025007331 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1173025007332 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1173025007333 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1173025007334 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173025007335 ATP binding site [chemical binding]; other site 1173025007336 putative Mg++ binding site [ion binding]; other site 1173025007337 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173025007338 nucleotide binding region [chemical binding]; other site 1173025007339 ATP-binding site [chemical binding]; other site 1173025007340 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1173025007341 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173025007342 ATP binding site [chemical binding]; other site 1173025007343 putative Mg++ binding site [ion binding]; other site 1173025007344 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173025007345 nucleotide binding region [chemical binding]; other site 1173025007346 ATP-binding site [chemical binding]; other site 1173025007347 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1173025007348 nucleotide binding site [chemical binding]; other site 1173025007349 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1173025007350 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1173025007351 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173025007352 ATP-binding site [chemical binding]; other site 1173025007353 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1173025007354 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1173025007355 PLD-like domain; Region: PLDc_2; pfam13091 1173025007356 putative active site [active] 1173025007357 catalytic site [active] 1173025007358 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1173025007359 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1173025007360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173025007361 dimer interface [polypeptide binding]; other site 1173025007362 conserved gate region; other site 1173025007363 putative PBP binding loops; other site 1173025007364 ABC-ATPase subunit interface; other site 1173025007365 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1173025007366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173025007367 ABC-ATPase subunit interface; other site 1173025007368 S-layer homology domain; Region: SLH; pfam00395 1173025007369 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1173025007370 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025007371 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025007372 binding surface 1173025007373 TPR motif; other site 1173025007374 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025007375 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025007376 binding surface 1173025007377 TPR motif; other site 1173025007378 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025007379 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025007380 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025007381 binding surface 1173025007382 TPR motif; other site 1173025007383 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025007384 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025007385 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025007386 binding surface 1173025007387 TPR motif; other site 1173025007388 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025007389 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 1173025007390 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1173025007391 N- and C-terminal domain interface [polypeptide binding]; other site 1173025007392 active site 1173025007393 MgATP binding site [chemical binding]; other site 1173025007394 catalytic site [active] 1173025007395 metal binding site [ion binding]; metal-binding site 1173025007396 glycerol binding site [chemical binding]; other site 1173025007397 homotetramer interface [polypeptide binding]; other site 1173025007398 homodimer interface [polypeptide binding]; other site 1173025007399 FBP binding site [chemical binding]; other site 1173025007400 protein IIAGlc interface [polypeptide binding]; other site 1173025007401 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 1173025007402 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1173025007403 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 1173025007404 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1173025007405 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1173025007406 glucosylglycerol-phosphate synthase; Region: gluc_glyc_Psyn; TIGR02398 1173025007407 active site 1173025007408 homotetramer interface [polypeptide binding]; other site 1173025007409 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1173025007410 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619 1173025007411 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1173025007412 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1173025007413 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1173025007414 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1173025007415 Walker A/P-loop; other site 1173025007416 ATP binding site [chemical binding]; other site 1173025007417 Q-loop/lid; other site 1173025007418 ABC transporter signature motif; other site 1173025007419 Walker B; other site 1173025007420 D-loop; other site 1173025007421 H-loop/switch region; other site 1173025007422 TOBE domain; Region: TOBE_2; pfam08402 1173025007423 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1173025007424 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1173025007425 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1173025007426 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 1173025007427 putative NAD(P) binding site [chemical binding]; other site 1173025007428 catalytic Zn binding site [ion binding]; other site 1173025007429 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173025007430 dimerization interface [polypeptide binding]; other site 1173025007431 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173025007432 cyclase homology domain; Region: CHD; cd07302 1173025007433 nucleotidyl binding site; other site 1173025007434 metal binding site [ion binding]; metal-binding site 1173025007435 dimer interface [polypeptide binding]; other site 1173025007436 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 1173025007437 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 1173025007438 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173025007439 putative DNA binding site [nucleotide binding]; other site 1173025007440 putative Zn2+ binding site [ion binding]; other site 1173025007441 ferredoxin thioreductase subunit beta; Validated; Region: ftrB; CHL00165 1173025007442 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1173025007443 putative ABC transporter; Region: ycf24; CHL00085 1173025007444 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 1173025007445 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1173025007446 Walker A/P-loop; other site 1173025007447 ATP binding site [chemical binding]; other site 1173025007448 Q-loop/lid; other site 1173025007449 ABC transporter signature motif; other site 1173025007450 Walker B; other site 1173025007451 D-loop; other site 1173025007452 H-loop/switch region; other site 1173025007453 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1173025007454 FeS assembly protein SufD; Region: sufD; TIGR01981 1173025007455 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1173025007456 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1173025007457 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173025007458 catalytic residue [active] 1173025007459 photosystem I subunit VII; Region: psaC; CHL00065 1173025007460 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1173025007461 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1173025007462 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1173025007463 glutaminase active site [active] 1173025007464 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1173025007465 dimer interface [polypeptide binding]; other site 1173025007466 active site 1173025007467 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1173025007468 dimer interface [polypeptide binding]; other site 1173025007469 active site 1173025007470 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1173025007471 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173025007472 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025007473 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025007474 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173025007475 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025007476 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173025007477 Walker A/P-loop; other site 1173025007478 ATP binding site [chemical binding]; other site 1173025007479 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 1173025007480 active site 1173025007481 zinc binding site [ion binding]; other site 1173025007482 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1173025007483 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 1173025007484 FOG: CBS domain [General function prediction only]; Region: COG0517 1173025007485 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1173025007486 FOG: CBS domain [General function prediction only]; Region: COG0517 1173025007487 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 1173025007488 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025007489 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173025007490 putative active site [active] 1173025007491 heme pocket [chemical binding]; other site 1173025007492 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173025007493 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025007494 putative active site [active] 1173025007495 heme pocket [chemical binding]; other site 1173025007496 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025007497 putative active site [active] 1173025007498 heme pocket [chemical binding]; other site 1173025007499 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025007500 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025007501 GAF domain; Region: GAF_2; pfam13185 1173025007502 GAF domain; Region: GAF; pfam01590 1173025007503 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025007504 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025007505 dimer interface [polypeptide binding]; other site 1173025007506 phosphorylation site [posttranslational modification] 1173025007507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025007508 ATP binding site [chemical binding]; other site 1173025007509 Mg2+ binding site [ion binding]; other site 1173025007510 G-X-G motif; other site 1173025007511 recombination factor protein RarA/unknown domain fusion protein; Reviewed; Region: PRK13341 1173025007512 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173025007513 Walker A motif; other site 1173025007514 ATP binding site [chemical binding]; other site 1173025007515 Walker B motif; other site 1173025007516 arginine finger; other site 1173025007517 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1173025007518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173025007519 S-adenosylmethionine binding site [chemical binding]; other site 1173025007520 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173025007521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1173025007522 DinB superfamily; Region: DinB_2; pfam12867 1173025007523 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173025007524 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1173025007525 NAD(P) binding site [chemical binding]; other site 1173025007526 active site 1173025007527 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1173025007528 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1173025007529 substrate binding site [chemical binding]; other site 1173025007530 active site 1173025007531 CpeS-like protein; Region: CpeS; pfam09367 1173025007532 translocon at the inner envelope of chloroplast subunit 62; Provisional; Region: PLN03209 1173025007533 OstA-like protein; Region: OstA; cl00844 1173025007534 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 1173025007535 photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655 1173025007536 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025007537 binding surface 1173025007538 TPR motif; other site 1173025007539 TPR repeat; Region: TPR_11; pfam13414 1173025007540 Protein of unknown function (DUF554); Region: DUF554; pfam04474 1173025007541 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1173025007542 9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732 1173025007543 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173025007544 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 1173025007545 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 1173025007546 putative hydrophobic ligand binding site [chemical binding]; other site 1173025007547 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 1173025007548 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1173025007549 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1173025007550 active site residue [active] 1173025007551 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1173025007552 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1173025007553 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1173025007554 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 1173025007555 putative active site [active] 1173025007556 dimer interface [polypeptide binding]; other site 1173025007557 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1173025007558 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1173025007559 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1173025007560 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1173025007561 Permease; Region: Permease; cl00510 1173025007562 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 1173025007563 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 1173025007564 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 1173025007565 tellurium resistance terB-like protein; Region: terB_like; cd07177 1173025007566 metal binding site [ion binding]; metal-binding site 1173025007567 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 1173025007568 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1173025007569 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1173025007570 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1173025007571 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1173025007572 putative tRNA-binding site [nucleotide binding]; other site 1173025007573 B3/4 domain; Region: B3_4; pfam03483 1173025007574 tRNA synthetase B5 domain; Region: B5; smart00874 1173025007575 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1173025007576 dimer interface [polypeptide binding]; other site 1173025007577 motif 1; other site 1173025007578 motif 3; other site 1173025007579 motif 2; other site 1173025007580 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1173025007581 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173025007582 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173025007583 active site 1173025007584 ATP binding site [chemical binding]; other site 1173025007585 substrate binding site [chemical binding]; other site 1173025007586 activation loop (A-loop); other site 1173025007587 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025007588 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173025007589 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025007590 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025007591 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1173025007592 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173025007593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025007594 active site 1173025007595 phosphorylation site [posttranslational modification] 1173025007596 intermolecular recognition site; other site 1173025007597 dimerization interface [polypeptide binding]; other site 1173025007598 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173025007599 DNA binding residues [nucleotide binding] 1173025007600 dimerization interface [polypeptide binding]; other site 1173025007601 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1173025007602 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1173025007603 active site 1173025007604 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1173025007605 catalytic triad [active] 1173025007606 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 1173025007607 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1173025007608 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1173025007609 alpha subunit interaction interface [polypeptide binding]; other site 1173025007610 Walker A motif; other site 1173025007611 ATP binding site [chemical binding]; other site 1173025007612 Walker B motif; other site 1173025007613 inhibitor binding site; inhibition site 1173025007614 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1173025007615 ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063 1173025007616 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1173025007617 gamma subunit interface [polypeptide binding]; other site 1173025007618 epsilon subunit interface [polypeptide binding]; other site 1173025007619 LBP interface [polypeptide binding]; other site 1173025007620 hypothetical protein; Provisional; Region: PRK02724 1173025007621 haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1 1173025007622 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 1173025007623 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025007624 binding surface 1173025007625 TPR motif; other site 1173025007626 TPR repeat; Region: TPR_11; pfam13414 1173025007627 Tetratricopeptide repeat; Region: TPR_9; pfam13371 1173025007628 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1173025007629 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173025007630 Walker A motif; other site 1173025007631 ATP binding site [chemical binding]; other site 1173025007632 Walker B motif; other site 1173025007633 arginine finger; other site 1173025007634 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1173025007635 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1173025007636 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1173025007637 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1173025007638 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 1173025007639 Mg++ binding site [ion binding]; other site 1173025007640 putative catalytic motif [active] 1173025007641 putative substrate binding site [chemical binding]; other site 1173025007642 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1173025007643 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173025007644 NAD(P) binding site [chemical binding]; other site 1173025007645 active site 1173025007646 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173025007647 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1173025007648 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1173025007649 active site 1173025007650 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 1173025007651 homodimer interface [polypeptide binding]; other site 1173025007652 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173025007653 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1173025007654 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1173025007655 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1173025007656 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1173025007657 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1173025007658 inhibitor-cofactor binding pocket; inhibition site 1173025007659 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173025007660 catalytic residue [active] 1173025007661 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1173025007662 active site 1173025007663 cosubstrate binding site; other site 1173025007664 substrate binding site [chemical binding]; other site 1173025007665 catalytic site [active] 1173025007666 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1173025007667 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1173025007668 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1173025007669 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1173025007670 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1173025007671 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1173025007672 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1173025007673 NAD(P) binding site [chemical binding]; other site 1173025007674 homodimer interface [polypeptide binding]; other site 1173025007675 substrate binding site [chemical binding]; other site 1173025007676 active site 1173025007677 O-Antigen ligase; Region: Wzy_C; pfam04932 1173025007678 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1173025007679 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1173025007680 Walker A/P-loop; other site 1173025007681 ATP binding site [chemical binding]; other site 1173025007682 Q-loop/lid; other site 1173025007683 ABC transporter signature motif; other site 1173025007684 Walker B; other site 1173025007685 D-loop; other site 1173025007686 H-loop/switch region; other site 1173025007687 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1173025007688 putative carbohydrate binding site [chemical binding]; other site 1173025007689 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173025007690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173025007691 S-adenosylmethionine binding site [chemical binding]; other site 1173025007692 hypothetical protein; Validated; Region: PRK00029 1173025007693 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1173025007694 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1173025007695 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1173025007696 catalytic triad [active] 1173025007697 hydrogenase accessory protein HypB; Region: hypB; TIGR00073 1173025007698 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1173025007699 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 1173025007700 agmatinase; Region: agmatinase; TIGR01230 1173025007701 Agmatinase-like family; Region: Agmatinase-like; cd09990 1173025007702 active site 1173025007703 oligomer interface [polypeptide binding]; other site 1173025007704 Mn binding site [ion binding]; other site 1173025007705 Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; cl02241 1173025007706 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 1173025007707 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1173025007708 Protein of unknown function (DUF98); Region: DUF98; pfam01947 1173025007709 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1173025007710 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1173025007711 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 1173025007712 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1173025007713 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1173025007714 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1173025007715 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1173025007716 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1173025007717 active site 1173025007718 catalytic triad [active] 1173025007719 oxyanion hole [active] 1173025007720 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1173025007721 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1173025007722 NHL repeat; Region: NHL; pfam01436 1173025007723 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1173025007724 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173025007725 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 1173025007726 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1173025007727 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173025007728 putative metal binding site [ion binding]; other site 1173025007729 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1173025007730 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1173025007731 metal-binding site [ion binding] 1173025007732 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173025007733 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1173025007734 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1173025007735 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1173025007736 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1173025007737 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173025007738 dimer interface [polypeptide binding]; other site 1173025007739 conserved gate region; other site 1173025007740 putative PBP binding loops; other site 1173025007741 ABC-ATPase subunit interface; other site 1173025007742 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1173025007743 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1173025007744 active site 1173025007745 substrate binding site [chemical binding]; other site 1173025007746 cosubstrate binding site; other site 1173025007747 catalytic site [active] 1173025007748 CAAX protease self-immunity; Region: Abi; pfam02517 1173025007749 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 1173025007750 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173025007751 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173025007752 catalytic loop [active] 1173025007753 iron binding site [ion binding]; other site 1173025007754 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1173025007755 core domain interface [polypeptide binding]; other site 1173025007756 delta subunit interface [polypeptide binding]; other site 1173025007757 epsilon subunit interface [polypeptide binding]; other site 1173025007758 ATP synthase CF1 alpha subunit; Region: atpA; CHL00059 1173025007759 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1173025007760 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1173025007761 beta subunit interaction interface [polypeptide binding]; other site 1173025007762 Walker A motif; other site 1173025007763 ATP binding site [chemical binding]; other site 1173025007764 Walker B motif; other site 1173025007765 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1173025007766 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 1173025007767 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1173025007768 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 1173025007769 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1173025007770 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 1173025007771 ATP synthase CF0 C subunit; Region: atpH; CHL00061 1173025007772 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1173025007773 ATP synthase CF0 A subunit; Region: atpI; CHL00046 1173025007774 ATP synthase I chain; Region: ATP_synt_I; pfam03899 1173025007775 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173025007776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173025007777 S-adenosylmethionine binding site [chemical binding]; other site 1173025007778 phycobillisome linker protein; Region: apcE; CHL00091 1173025007779 Phycobilisome protein; Region: Phycobilisome; cl08227 1173025007780 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173025007781 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173025007782 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173025007783 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173025007784 Phycobilisome protein; Region: Phycobilisome; cl08227 1173025007785 allophycocyanin beta subunit; Region: apcB; CHL00088 1173025007786 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 1173025007787 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 1173025007788 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1173025007789 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1173025007790 c-type cytochrome biogenensis protein; Validated; Region: ccs1; CHL00177 1173025007791 ResB-like family; Region: ResB; pfam05140 1173025007792 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 1173025007793 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1173025007794 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1173025007795 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1173025007796 active site 1173025007797 dimerization interface [polypeptide binding]; other site 1173025007798 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1173025007799 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 1173025007800 active site 1173025007801 substrate binding site [chemical binding]; other site 1173025007802 metal binding site [ion binding]; metal-binding site 1173025007803 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025007804 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025007805 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025007806 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025007807 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025007808 ATP binding site [chemical binding]; other site 1173025007809 Mg2+ binding site [ion binding]; other site 1173025007810 G-X-G motif; other site 1173025007811 Protein of unknown function (DUF3580); Region: DUF3580; pfam12117 1173025007812 Predicted permeases [General function prediction only]; Region: COG0701 1173025007813 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 1173025007814 TIGR03943 family protein; Region: TIGR03943 1173025007815 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1173025007816 Flavoprotein; Region: Flavoprotein; pfam02441 1173025007817 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1173025007818 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 1173025007819 putative hydrolase; Provisional; Region: PRK11460 1173025007820 Predicted esterase [General function prediction only]; Region: COG0400 1173025007821 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1173025007822 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1173025007823 DNA-binding site [nucleotide binding]; DNA binding site 1173025007824 FCD domain; Region: FCD; pfam07729 1173025007825 2-isopropylmalate synthase; Validated; Region: PRK00915 1173025007826 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1173025007827 active site 1173025007828 catalytic residues [active] 1173025007829 metal binding site [ion binding]; metal-binding site 1173025007830 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1173025007831 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1173025007832 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1173025007833 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1173025007834 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1173025007835 Walker A/P-loop; other site 1173025007836 ATP binding site [chemical binding]; other site 1173025007837 Q-loop/lid; other site 1173025007838 ABC transporter signature motif; other site 1173025007839 Walker B; other site 1173025007840 D-loop; other site 1173025007841 H-loop/switch region; other site 1173025007842 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1173025007843 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1173025007844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173025007845 dimer interface [polypeptide binding]; other site 1173025007846 conserved gate region; other site 1173025007847 ABC-ATPase subunit interface; other site 1173025007848 TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950 1173025007849 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1173025007850 catalytic residues [active] 1173025007851 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 1173025007852 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1173025007853 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 1173025007854 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1173025007855 metal ion-dependent adhesion site (MIDAS); other site 1173025007856 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1173025007857 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173025007858 active site 1173025007859 metal binding site [ion binding]; metal-binding site 1173025007860 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1173025007861 active site 1173025007862 metal binding site [ion binding]; metal-binding site 1173025007863 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1173025007864 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1173025007865 putative active site cavity [active] 1173025007866 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025007867 GAF domain; Region: GAF; pfam01590 1173025007868 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025007869 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025007870 dimer interface [polypeptide binding]; other site 1173025007871 phosphorylation site [posttranslational modification] 1173025007872 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025007873 ATP binding site [chemical binding]; other site 1173025007874 Mg2+ binding site [ion binding]; other site 1173025007875 G-X-G motif; other site 1173025007876 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025007877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025007878 active site 1173025007879 phosphorylation site [posttranslational modification] 1173025007880 intermolecular recognition site; other site 1173025007881 dimerization interface [polypeptide binding]; other site 1173025007882 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1173025007883 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1173025007884 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1173025007885 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1173025007886 putative active site [active] 1173025007887 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1173025007888 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1173025007889 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1173025007890 protein binding site [polypeptide binding]; other site 1173025007891 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1173025007892 Catalytic dyad [active] 1173025007893 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 1173025007894 D1 interface; other site 1173025007895 chlorophyll binding site; other site 1173025007896 pheophytin binding site; other site 1173025007897 beta carotene binding site; other site 1173025007898 cytochrome b559 beta interface; other site 1173025007899 quinone binding site; other site 1173025007900 cytochrome b559 alpha interface; other site 1173025007901 protein J interface; other site 1173025007902 protein H interface; other site 1173025007903 protein X interface; other site 1173025007904 core light harvesting protein interface; other site 1173025007905 protein L interface; other site 1173025007906 CP43 interface; other site 1173025007907 protein T interface; other site 1173025007908 Fe binding site [ion binding]; other site 1173025007909 protein M interface; other site 1173025007910 Mn-stabilizing polypeptide interface; other site 1173025007911 bromide binding site; other site 1173025007912 cytochrome c-550 interface; other site 1173025007913 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1173025007914 aromatic arch; other site 1173025007915 DCoH dimer interaction site [polypeptide binding]; other site 1173025007916 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1173025007917 DCoH tetramer interaction site [polypeptide binding]; other site 1173025007918 substrate binding site [chemical binding]; other site 1173025007919 S-layer homology domain; Region: SLH; pfam00395 1173025007920 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1173025007921 NDF6 (NDH-dependent flow 6); Provisional; Region: PLN00180 1173025007922 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1173025007923 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1173025007924 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1173025007925 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 1173025007926 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 1173025007927 DNA repair protein RadA; Provisional; Region: PRK11823 1173025007928 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1173025007929 Walker A motif; other site 1173025007930 ATP binding site [chemical binding]; other site 1173025007931 Walker B motif; other site 1173025007932 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1173025007933 Ycf27; Reviewed; Region: orf27; CHL00148 1173025007934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025007935 active site 1173025007936 phosphorylation site [posttranslational modification] 1173025007937 intermolecular recognition site; other site 1173025007938 dimerization interface [polypeptide binding]; other site 1173025007939 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173025007940 DNA binding site [nucleotide binding] 1173025007941 putative phosphate acyltransferase; Provisional; Region: PRK05331 1173025007942 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1173025007943 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1173025007944 dimer interface [polypeptide binding]; other site 1173025007945 active site 1173025007946 CoA binding pocket [chemical binding]; other site 1173025007947 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1173025007948 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1173025007949 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1173025007950 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1173025007951 putative acyl-acceptor binding pocket; other site 1173025007952 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 1173025007953 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1173025007954 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1173025007955 putative active site [active] 1173025007956 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1173025007957 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1173025007958 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1173025007959 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1173025007960 active site 1173025007961 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1173025007962 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1173025007963 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1173025007964 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1173025007965 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1173025007966 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1173025007967 Surface antigen; Region: Bac_surface_Ag; pfam01103 1173025007968 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1173025007969 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1173025007970 ATP binding site [chemical binding]; other site 1173025007971 active site 1173025007972 substrate binding site [chemical binding]; other site 1173025007973 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1173025007974 autotransport protein MisL; Provisional; Region: PRK15313 1173025007975 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 1173025007976 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1173025007977 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1173025007978 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1173025007979 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1173025007980 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173025007981 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1173025007982 Probable transposase; Region: OrfB_IS605; pfam01385 1173025007983 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173025007984 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1173025007985 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1173025007986 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1173025007987 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1173025007988 E3 interaction surface; other site 1173025007989 lipoyl attachment site [posttranslational modification]; other site 1173025007990 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173025007991 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173025007992 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173025007993 ligand binding site [chemical binding]; other site 1173025007994 flexible hinge region; other site 1173025007995 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1173025007996 Peptidase C39 family; Region: Peptidase_C39; pfam03412 1173025007997 putative active site [active] 1173025007998 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173025007999 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 1173025008000 Walker A/P-loop; other site 1173025008001 ATP binding site [chemical binding]; other site 1173025008002 Q-loop/lid; other site 1173025008003 ABC transporter signature motif; other site 1173025008004 Walker B; other site 1173025008005 D-loop; other site 1173025008006 H-loop/switch region; other site 1173025008007 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1173025008008 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1173025008009 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173025008010 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173025008011 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173025008012 ligand binding site [chemical binding]; other site 1173025008013 flexible hinge region; other site 1173025008014 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1173025008015 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 1173025008016 putative active site [active] 1173025008017 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173025008018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173025008019 Walker A/P-loop; other site 1173025008020 ATP binding site [chemical binding]; other site 1173025008021 Q-loop/lid; other site 1173025008022 ABC transporter signature motif; other site 1173025008023 Walker B; other site 1173025008024 D-loop; other site 1173025008025 H-loop/switch region; other site 1173025008026 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1173025008027 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1173025008028 ATP synthase CF1 alpha subunit; Region: atpA; CHL00059 1173025008029 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 1173025008030 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173025008031 FeS/SAM binding site; other site 1173025008032 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 1173025008033 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1173025008034 Cysteine-rich domain; Region: CCG; pfam02754 1173025008035 Cysteine-rich domain; Region: CCG; pfam02754 1173025008036 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1173025008037 FAD binding domain; Region: FAD_binding_4; pfam01565 1173025008038 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1173025008039 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 1173025008040 Predicted membrane protein [Function unknown]; Region: COG1950 1173025008041 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1173025008042 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1173025008043 catalytic residues [active] 1173025008044 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1173025008045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173025008046 putative substrate translocation pore; other site 1173025008047 TPR repeat; Region: TPR_11; pfam13414 1173025008048 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025008049 binding surface 1173025008050 TPR motif; other site 1173025008051 TPR repeat; Region: TPR_11; pfam13414 1173025008052 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025008053 binding surface 1173025008054 TPR motif; other site 1173025008055 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173025008056 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 1173025008057 active site 1173025008058 catalytic triad [active] 1173025008059 oxyanion hole [active] 1173025008060 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1173025008061 HD domain; Region: HD_4; pfam13328 1173025008062 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1173025008063 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1173025008064 Walker A/P-loop; other site 1173025008065 ATP binding site [chemical binding]; other site 1173025008066 Q-loop/lid; other site 1173025008067 ABC transporter signature motif; other site 1173025008068 Walker B; other site 1173025008069 D-loop; other site 1173025008070 H-loop/switch region; other site 1173025008071 TOBE domain; Region: TOBE_2; pfam08402 1173025008072 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 1173025008073 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1173025008074 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 1173025008075 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1173025008076 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1173025008077 active site 1173025008078 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1173025008079 active site 1173025008080 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1173025008081 catalytic core [active] 1173025008082 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1173025008083 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1173025008084 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1173025008085 Walker A/P-loop; other site 1173025008086 ATP binding site [chemical binding]; other site 1173025008087 Q-loop/lid; other site 1173025008088 ABC transporter signature motif; other site 1173025008089 Walker B; other site 1173025008090 D-loop; other site 1173025008091 H-loop/switch region; other site 1173025008092 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1173025008093 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1173025008094 homodimer interface [polypeptide binding]; other site 1173025008095 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173025008096 catalytic residue [active] 1173025008097 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1173025008098 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1173025008099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173025008100 S-adenosylmethionine binding site [chemical binding]; other site 1173025008101 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1173025008102 phosphatidate cytidylyltransferase; Region: PLN02953 1173025008103 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1173025008104 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1173025008105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 1173025008106 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1173025008107 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1173025008108 inhibitor-cofactor binding pocket; inhibition site 1173025008109 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173025008110 catalytic residue [active] 1173025008111 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1173025008112 ABC1 family; Region: ABC1; cl17513 1173025008113 phenylalanine transporter; Provisional; Region: PRK10249 1173025008114 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 1173025008115 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1173025008116 ATP binding site [chemical binding]; other site 1173025008117 putative Mg++ binding site [ion binding]; other site 1173025008118 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1173025008119 Dihaem cytochrome c; Region: DHC; pfam09626 1173025008120 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173025008121 Coenzyme A binding pocket [chemical binding]; other site 1173025008122 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025008123 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025008124 dimer interface [polypeptide binding]; other site 1173025008125 phosphorylation site [posttranslational modification] 1173025008126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025008127 ATP binding site [chemical binding]; other site 1173025008128 G-X-G motif; other site 1173025008129 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1173025008130 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1173025008131 NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415 1173025008132 MraW methylase family; Region: Methyltransf_5; cl17771 1173025008133 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1173025008134 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025008135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025008136 active site 1173025008137 phosphorylation site [posttranslational modification] 1173025008138 intermolecular recognition site; other site 1173025008139 dimerization interface [polypeptide binding]; other site 1173025008140 PAS domain S-box; Region: sensory_box; TIGR00229 1173025008141 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025008142 putative active site [active] 1173025008143 heme pocket [chemical binding]; other site 1173025008144 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025008145 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025008146 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025008147 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025008148 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025008149 dimer interface [polypeptide binding]; other site 1173025008150 phosphorylation site [posttranslational modification] 1173025008151 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025008152 ATP binding site [chemical binding]; other site 1173025008153 Mg2+ binding site [ion binding]; other site 1173025008154 G-X-G motif; other site 1173025008155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025008156 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025008157 active site 1173025008158 phosphorylation site [posttranslational modification] 1173025008159 intermolecular recognition site; other site 1173025008160 dimerization interface [polypeptide binding]; other site 1173025008161 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025008162 PAS domain; Region: PAS_9; pfam13426 1173025008163 putative active site [active] 1173025008164 heme pocket [chemical binding]; other site 1173025008165 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025008166 PAS fold; Region: PAS_3; pfam08447 1173025008167 putative active site [active] 1173025008168 heme pocket [chemical binding]; other site 1173025008169 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025008170 dimer interface [polypeptide binding]; other site 1173025008171 phosphorylation site [posttranslational modification] 1173025008172 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1173025008173 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025008174 ATP binding site [chemical binding]; other site 1173025008175 Mg2+ binding site [ion binding]; other site 1173025008176 G-X-G motif; other site 1173025008177 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 1173025008178 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1173025008179 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1173025008180 DNA-binding site [nucleotide binding]; DNA binding site 1173025008181 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1173025008182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173025008183 homodimer interface [polypeptide binding]; other site 1173025008184 catalytic residue [active] 1173025008185 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1173025008186 MutS domain I; Region: MutS_I; pfam01624 1173025008187 MutS domain II; Region: MutS_II; pfam05188 1173025008188 MutS domain III; Region: MutS_III; pfam05192 1173025008189 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1173025008190 Walker A/P-loop; other site 1173025008191 ATP binding site [chemical binding]; other site 1173025008192 Q-loop/lid; other site 1173025008193 ABC transporter signature motif; other site 1173025008194 Walker B; other site 1173025008195 D-loop; other site 1173025008196 H-loop/switch region; other site 1173025008197 Translocation protein Sec62; Region: Sec62; cl02170 1173025008198 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1173025008199 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1173025008200 putative active site [active] 1173025008201 substrate binding site [chemical binding]; other site 1173025008202 putative cosubstrate binding site; other site 1173025008203 catalytic site [active] 1173025008204 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1173025008205 substrate binding site [chemical binding]; other site 1173025008206 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1173025008207 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1173025008208 ligand binding site [chemical binding]; other site 1173025008209 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 1173025008210 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 1173025008211 Uncharacterized conserved protein [Function unknown]; Region: COG1565 1173025008212 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1173025008213 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1173025008214 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173025008215 catalytic residue [active] 1173025008216 YacP-like NYN domain; Region: NYN_YacP; cl01491 1173025008217 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1173025008218 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1173025008219 Walker A/P-loop; other site 1173025008220 ATP binding site [chemical binding]; other site 1173025008221 Q-loop/lid; other site 1173025008222 ABC transporter signature motif; other site 1173025008223 Walker B; other site 1173025008224 D-loop; other site 1173025008225 H-loop/switch region; other site 1173025008226 hypothetical protein; Provisional; Region: PRK13683 1173025008227 AMIN domain; Region: AMIN; pfam11741 1173025008228 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 1173025008229 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1173025008230 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1173025008231 glutathione reductase; Validated; Region: PRK06116 1173025008232 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173025008233 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1173025008234 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173025008235 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025008236 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173025008237 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025008238 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025008239 PAS domain; Region: PAS_9; pfam13426 1173025008240 putative active site [active] 1173025008241 heme pocket [chemical binding]; other site 1173025008242 PAS domain S-box; Region: sensory_box; TIGR00229 1173025008243 PAS domain; Region: PAS_8; pfam13188 1173025008244 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025008245 GAF domain; Region: GAF; pfam01590 1173025008246 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025008247 PAS domain; Region: PAS_9; pfam13426 1173025008248 putative active site [active] 1173025008249 heme pocket [chemical binding]; other site 1173025008250 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025008251 PAS fold; Region: PAS_3; pfam08447 1173025008252 putative active site [active] 1173025008253 heme pocket [chemical binding]; other site 1173025008254 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173025008255 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173025008256 metal binding site [ion binding]; metal-binding site 1173025008257 active site 1173025008258 I-site; other site 1173025008259 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1173025008260 Uncharacterized conserved protein [Function unknown]; Region: COG3743 1173025008261 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1173025008262 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1173025008263 generic binding surface II; other site 1173025008264 ssDNA binding site; other site 1173025008265 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173025008266 ATP binding site [chemical binding]; other site 1173025008267 putative Mg++ binding site [ion binding]; other site 1173025008268 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173025008269 nucleotide binding region [chemical binding]; other site 1173025008270 ATP-binding site [chemical binding]; other site 1173025008271 elongation factor Ts; Reviewed; Region: tsf; PRK12332 1173025008272 UBA/TS-N domain; Region: UBA; pfam00627 1173025008273 Elongation factor TS; Region: EF_TS; pfam00889 1173025008274 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1173025008275 rRNA interaction site [nucleotide binding]; other site 1173025008276 S8 interaction site; other site 1173025008277 putative laminin-1 binding site; other site 1173025008278 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1173025008279 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1173025008280 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173025008281 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173025008282 active site 1173025008283 argininosuccinate synthase; Provisional; Region: PRK13820 1173025008284 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1173025008285 ANP binding site [chemical binding]; other site 1173025008286 Substrate Binding Site II [chemical binding]; other site 1173025008287 Substrate Binding Site I [chemical binding]; other site 1173025008288 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1173025008289 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1173025008290 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1173025008291 anti sigma factor interaction site; other site 1173025008292 regulatory phosphorylation site [posttranslational modification]; other site 1173025008293 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 1173025008294 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1173025008295 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173025008296 DNA polymerase III subunit beta; Validated; Region: PRK05643 1173025008297 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1173025008298 putative DNA binding surface [nucleotide binding]; other site 1173025008299 dimer interface [polypeptide binding]; other site 1173025008300 beta-clamp/clamp loader binding surface; other site 1173025008301 beta-clamp/translesion DNA polymerase binding surface; other site 1173025008302 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025008303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025008304 active site 1173025008305 phosphorylation site [posttranslational modification] 1173025008306 intermolecular recognition site; other site 1173025008307 dimerization interface [polypeptide binding]; other site 1173025008308 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025008309 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025008310 dimer interface [polypeptide binding]; other site 1173025008311 phosphorylation site [posttranslational modification] 1173025008312 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025008313 ATP binding site [chemical binding]; other site 1173025008314 Mg2+ binding site [ion binding]; other site 1173025008315 G-X-G motif; other site 1173025008316 MASE1; Region: MASE1; pfam05231 1173025008317 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025008318 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025008319 dimer interface [polypeptide binding]; other site 1173025008320 phosphorylation site [posttranslational modification] 1173025008321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025008322 ATP binding site [chemical binding]; other site 1173025008323 Mg2+ binding site [ion binding]; other site 1173025008324 G-X-G motif; other site 1173025008325 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173025008326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025008327 active site 1173025008328 phosphorylation site [posttranslational modification] 1173025008329 intermolecular recognition site; other site 1173025008330 dimerization interface [polypeptide binding]; other site 1173025008331 HNH endonuclease; Region: HNH_5; pfam14279 1173025008332 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 1173025008333 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 1173025008334 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 1173025008335 S-layer homology domain; Region: SLH; pfam00395 1173025008336 S-layer homology domain; Region: SLH; pfam00395 1173025008337 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 1173025008338 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1173025008339 translation initiation factor IF-2; Validated; Region: infB; PRK05306 1173025008340 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1173025008341 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1173025008342 G1 box; other site 1173025008343 putative GEF interaction site [polypeptide binding]; other site 1173025008344 GTP/Mg2+ binding site [chemical binding]; other site 1173025008345 Switch I region; other site 1173025008346 G2 box; other site 1173025008347 G3 box; other site 1173025008348 Switch II region; other site 1173025008349 G4 box; other site 1173025008350 G5 box; other site 1173025008351 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1173025008352 Translation-initiation factor 2; Region: IF-2; pfam11987 1173025008353 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1173025008354 Protein of unknown function (DUF448); Region: DUF448; pfam04296 1173025008355 putative RNA binding cleft [nucleotide binding]; other site 1173025008356 NusA N-terminal domain; Region: NusA_N; pfam08529 1173025008357 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1173025008358 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1173025008359 RNA binding site [nucleotide binding]; other site 1173025008360 homodimer interface [polypeptide binding]; other site 1173025008361 NusA-like KH domain; Region: KH_5; pfam13184 1173025008362 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1173025008363 G-X-X-G motif; other site 1173025008364 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1173025008365 Sm and related proteins; Region: Sm_like; cl00259 1173025008366 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1173025008367 putative oligomer interface [polypeptide binding]; other site 1173025008368 putative RNA binding site [nucleotide binding]; other site 1173025008369 Tocopherol cyclase; Region: Tocopherol_cycl; pfam14249 1173025008370 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1173025008371 Domain of unknown function (DUF3474); Region: DUF3474; pfam11960 1173025008372 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1173025008373 putative di-iron ligands [ion binding]; other site 1173025008374 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1173025008375 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1173025008376 putative di-iron ligands [ion binding]; other site 1173025008377 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173025008378 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025008379 active site 1173025008380 phosphorylation site [posttranslational modification] 1173025008381 intermolecular recognition site; other site 1173025008382 dimerization interface [polypeptide binding]; other site 1173025008383 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1173025008384 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025008385 dimer interface [polypeptide binding]; other site 1173025008386 phosphorylation site [posttranslational modification] 1173025008387 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025008388 ATP binding site [chemical binding]; other site 1173025008389 Mg2+ binding site [ion binding]; other site 1173025008390 G-X-G motif; other site 1173025008391 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025008392 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025008393 active site 1173025008394 phosphorylation site [posttranslational modification] 1173025008395 intermolecular recognition site; other site 1173025008396 dimerization interface [polypeptide binding]; other site 1173025008397 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025008398 GAF domain; Region: GAF; pfam01590 1173025008399 PAS domain S-box; Region: sensory_box; TIGR00229 1173025008400 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025008401 putative active site [active] 1173025008402 heme pocket [chemical binding]; other site 1173025008403 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025008404 dimer interface [polypeptide binding]; other site 1173025008405 phosphorylation site [posttranslational modification] 1173025008406 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025008407 ATP binding site [chemical binding]; other site 1173025008408 Mg2+ binding site [ion binding]; other site 1173025008409 G-X-G motif; other site 1173025008410 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1173025008411 Clp protease; Region: CLP_protease; pfam00574 1173025008412 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1173025008413 oligomer interface [polypeptide binding]; other site 1173025008414 active site residues [active] 1173025008415 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025008416 GAF domain; Region: GAF; pfam01590 1173025008417 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025008418 GAF domain; Region: GAF; pfam01590 1173025008419 GAF domain; Region: GAF_3; pfam13492 1173025008420 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1173025008421 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1173025008422 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1173025008423 quinone interaction residues [chemical binding]; other site 1173025008424 active site 1173025008425 catalytic residues [active] 1173025008426 FMN binding site [chemical binding]; other site 1173025008427 substrate binding site [chemical binding]; other site 1173025008428 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1173025008429 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173025008430 cyclase homology domain; Region: CHD; cd07302 1173025008431 nucleotidyl binding site; other site 1173025008432 metal binding site [ion binding]; metal-binding site 1173025008433 dimer interface [polypeptide binding]; other site 1173025008434 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1173025008435 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1173025008436 catalytic residues [active] 1173025008437 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1173025008438 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1173025008439 NAD(P) binding site [chemical binding]; other site 1173025008440 homotetramer interface [polypeptide binding]; other site 1173025008441 homodimer interface [polypeptide binding]; other site 1173025008442 active site 1173025008443 Protein of unknown function (DUF3122); Region: DUF3122; pfam11320 1173025008444 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK07432 1173025008445 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 1173025008446 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1173025008447 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1173025008448 Protein export membrane protein; Region: SecD_SecF; pfam02355 1173025008449 protein-export membrane protein SecD; Region: secD; TIGR01129 1173025008450 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1173025008451 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 1173025008452 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1173025008453 alpha subunit interface [polypeptide binding]; other site 1173025008454 TPP binding site [chemical binding]; other site 1173025008455 heterodimer interface [polypeptide binding]; other site 1173025008456 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1173025008457 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 1173025008458 active site 1173025008459 catalytic triad [active] 1173025008460 oxyanion hole [active] 1173025008461 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1173025008462 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1173025008463 putative substrate binding site [chemical binding]; other site 1173025008464 putative ATP binding site [chemical binding]; other site 1173025008465 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 1173025008466 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746 1173025008467 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1173025008468 PetM family of cytochrome b6f complex subunit 7; Region: PetM; pfam08041 1173025008469 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173025008470 putative DNA binding site [nucleotide binding]; other site 1173025008471 dimerization interface [polypeptide binding]; other site 1173025008472 putative Zn2+ binding site [ion binding]; other site 1173025008473 Ycf39; Provisional; Region: ycf39; CHL00194 1173025008474 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1173025008475 NAD(P) binding site [chemical binding]; other site 1173025008476 putative active site [active] 1173025008477 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649 1173025008478 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1173025008479 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173025008480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025008481 active site 1173025008482 phosphorylation site [posttranslational modification] 1173025008483 intermolecular recognition site; other site 1173025008484 dimerization interface [polypeptide binding]; other site 1173025008485 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173025008486 DNA binding site [nucleotide binding] 1173025008487 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 1173025008488 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 1173025008489 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 1173025008490 homodimer interface [polypeptide binding]; other site 1173025008491 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173025008492 catalytic residue [active] 1173025008493 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1173025008494 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1173025008495 Surface antigen; Region: Bac_surface_Ag; pfam01103 1173025008496 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173025008497 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1173025008498 CHAT domain; Region: CHAT; cl17868 1173025008499 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1173025008500 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1173025008501 active site 1173025008502 catalytic tetrad [active] 1173025008503 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 1173025008504 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 1173025008505 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1173025008506 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1173025008507 DNA binding residues [nucleotide binding] 1173025008508 dimer interface [polypeptide binding]; other site 1173025008509 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; COG2082 1173025008510 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 1173025008511 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1173025008512 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173025008513 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1173025008514 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025008515 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173025008516 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025008517 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025008518 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025008519 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025008520 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025008521 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025008522 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1173025008523 putative cation:proton antiport protein; Provisional; Region: PRK10669 1173025008524 TrkA-N domain; Region: TrkA_N; pfam02254 1173025008525 TrkA-C domain; Region: TrkA_C; pfam02080 1173025008526 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1173025008527 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1173025008528 active site 1173025008529 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1173025008530 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1173025008531 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1173025008532 PAS fold; Region: PAS; pfam00989 1173025008533 PAS domain; Region: PAS; smart00091 1173025008534 PAS fold; Region: PAS_4; pfam08448 1173025008535 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025008536 GAF domain; Region: GAF; pfam01590 1173025008537 PAS domain S-box; Region: sensory_box; TIGR00229 1173025008538 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025008539 putative active site [active] 1173025008540 heme pocket [chemical binding]; other site 1173025008541 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025008542 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173025008543 putative active site [active] 1173025008544 heme pocket [chemical binding]; other site 1173025008545 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 1173025008546 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025008547 putative active site [active] 1173025008548 heme pocket [chemical binding]; other site 1173025008549 PAS domain; Region: PAS; smart00091 1173025008550 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025008551 dimer interface [polypeptide binding]; other site 1173025008552 phosphorylation site [posttranslational modification] 1173025008553 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025008554 ATP binding site [chemical binding]; other site 1173025008555 Mg2+ binding site [ion binding]; other site 1173025008556 G-X-G motif; other site 1173025008557 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1173025008558 active site 1173025008559 DNA binding site [nucleotide binding] 1173025008560 Phospholipid methyltransferase; Region: PEMT; cl17370 1173025008561 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1173025008562 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173025008563 NAD(P) binding site [chemical binding]; other site 1173025008564 active site 1173025008565 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1173025008566 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1173025008567 active site 1173025008568 homodimer interface [polypeptide binding]; other site 1173025008569 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1173025008570 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1173025008571 metal ion-dependent adhesion site (MIDAS); other site 1173025008572 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1173025008573 putative ADP-ribose binding site [chemical binding]; other site 1173025008574 putative active site [active] 1173025008575 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025008576 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025008577 binding surface 1173025008578 TPR motif; other site 1173025008579 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025008580 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025008581 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025008582 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025008583 binding surface 1173025008584 TPR motif; other site 1173025008585 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025008586 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025008587 binding surface 1173025008588 TPR motif; other site 1173025008589 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025008590 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025008591 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025008592 binding surface 1173025008593 TPR motif; other site 1173025008594 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025008595 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025008596 CHAT domain; Region: CHAT; pfam12770 1173025008597 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173025008598 active site 1173025008599 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1173025008600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173025008601 dimer interface [polypeptide binding]; other site 1173025008602 conserved gate region; other site 1173025008603 putative PBP binding loops; other site 1173025008604 ABC-ATPase subunit interface; other site 1173025008605 CutA1 divalent ion tolerance protein; Region: CutA1; pfam03091 1173025008606 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1173025008607 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1173025008608 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 1173025008609 Ligand Binding Site [chemical binding]; other site 1173025008610 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1173025008611 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1173025008612 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 1173025008613 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173025008614 Walker A/P-loop; other site 1173025008615 ATP binding site [chemical binding]; other site 1173025008616 Q-loop/lid; other site 1173025008617 ABC transporter signature motif; other site 1173025008618 Walker B; other site 1173025008619 D-loop; other site 1173025008620 H-loop/switch region; other site 1173025008621 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 1173025008622 active site 1173025008623 catalytic site [active] 1173025008624 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1173025008625 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 1173025008626 Photosystem II reaction centre N protein (psbN); Region: PsbN; pfam02468 1173025008627 photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624 1173025008628 twin arginine translocase protein A; Provisional; Region: tatA; PRK14857 1173025008629 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1173025008630 putative active site [active] 1173025008631 catalytic residue [active] 1173025008632 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 1173025008633 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1173025008634 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 1173025008635 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 1173025008636 GAGA binding protein-like family; Region: GAGA_bind; pfam06217 1173025008637 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173025008638 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 1173025008639 ligand binding site [chemical binding]; other site 1173025008640 flexible hinge region; other site 1173025008641 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1173025008642 putative switch regulator; other site 1173025008643 non-specific DNA interactions [nucleotide binding]; other site 1173025008644 DNA binding site [nucleotide binding] 1173025008645 sequence specific DNA binding site [nucleotide binding]; other site 1173025008646 putative cAMP binding site [chemical binding]; other site 1173025008647 homoserine kinase; Provisional; Region: PRK01212 1173025008648 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1173025008649 M28 Zn-Peptidases; Region: M28_like_1; cd05640 1173025008650 Peptidase family M28; Region: Peptidase_M28; pfam04389 1173025008651 metal binding site [ion binding]; metal-binding site 1173025008652 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1173025008653 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1173025008654 Substrate binding site; other site 1173025008655 Cupin domain; Region: Cupin_2; cl17218 1173025008656 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1173025008657 ABC1 family; Region: ABC1; pfam03109 1173025008658 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1173025008659 active site 1173025008660 ATP binding site [chemical binding]; other site 1173025008661 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1173025008662 DNA-binding site [nucleotide binding]; DNA binding site 1173025008663 RNA-binding motif; other site 1173025008664 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 1173025008665 Nuclease-related domain; Region: NERD; pfam08378 1173025008666 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1173025008667 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 1173025008668 PLD-like domain; Region: PLDc_2; pfam13091 1173025008669 putative homodimer interface [polypeptide binding]; other site 1173025008670 putative active site [active] 1173025008671 catalytic site [active] 1173025008672 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1173025008673 active site 1173025008674 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 1173025008675 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1173025008676 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173025008677 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1173025008678 active site clefts [active] 1173025008679 zinc binding site [ion binding]; other site 1173025008680 dimer interface [polypeptide binding]; other site 1173025008681 NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363 1173025008682 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173025008683 CO2 hydration protein (ChpXY); Region: ChpXY; cl10905 1173025008684 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1173025008685 Fasciclin domain; Region: Fasciclin; pfam02469 1173025008686 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 1173025008687 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173025008688 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025008689 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173025008690 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025008691 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025008692 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1173025008693 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1173025008694 substrate binding site [chemical binding]; other site 1173025008695 ligand binding site [chemical binding]; other site 1173025008696 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1173025008697 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1173025008698 substrate binding site [chemical binding]; other site 1173025008699 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1173025008700 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1173025008701 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 1173025008702 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173025008703 Walker A motif; other site 1173025008704 ATP binding site [chemical binding]; other site 1173025008705 Walker B motif; other site 1173025008706 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1173025008707 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1173025008708 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173025008709 catalytic residue [active] 1173025008710 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 1173025008711 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1173025008712 RNase_H superfamily; Region: RNase_H_2; pfam13482 1173025008713 Repair protein; Region: Repair_PSII; pfam04536 1173025008714 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1173025008715 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 1173025008716 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1173025008717 carboxyltransferase (CT) interaction site; other site 1173025008718 biotinylation site [posttranslational modification]; other site 1173025008719 elongation factor P; Validated; Region: PRK00529 1173025008720 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1173025008721 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1173025008722 RNA binding site [nucleotide binding]; other site 1173025008723 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1173025008724 RNA binding site [nucleotide binding]; other site 1173025008725 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 1173025008726 active site 1173025008727 thiamine monophosphate kinase; Provisional; Region: PRK05731 1173025008728 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1173025008729 ATP binding site [chemical binding]; other site 1173025008730 dimerization interface [polypeptide binding]; other site 1173025008731 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 1173025008732 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1173025008733 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1173025008734 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1173025008735 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1173025008736 active site 1173025008737 (T/H)XGH motif; other site 1173025008738 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1173025008739 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1173025008740 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1173025008741 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1173025008742 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1173025008743 FAD binding domain; Region: FAD_binding_4; pfam01565 1173025008744 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1173025008745 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1173025008746 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1173025008747 G1 box; other site 1173025008748 putative GEF interaction site [polypeptide binding]; other site 1173025008749 GTP/Mg2+ binding site [chemical binding]; other site 1173025008750 Switch I region; other site 1173025008751 G2 box; other site 1173025008752 G3 box; other site 1173025008753 Switch II region; other site 1173025008754 G4 box; other site 1173025008755 G5 box; other site 1173025008756 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1173025008757 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1173025008758 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1173025008759 elongation factor G; Reviewed; Region: PRK12740 1173025008760 G1 box; other site 1173025008761 putative GEF interaction site [polypeptide binding]; other site 1173025008762 GTP/Mg2+ binding site [chemical binding]; other site 1173025008763 Switch I region; other site 1173025008764 G2 box; other site 1173025008765 G3 box; other site 1173025008766 Switch II region; other site 1173025008767 G4 box; other site 1173025008768 G5 box; other site 1173025008769 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1173025008770 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1173025008771 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1173025008772 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 1173025008773 FO synthase subunit 2; Reviewed; Region: PRK07360 1173025008774 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 1173025008775 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1173025008776 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1173025008777 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1173025008778 Ligand Binding Site [chemical binding]; other site 1173025008779 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1173025008780 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1173025008781 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1173025008782 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025008783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025008784 active site 1173025008785 phosphorylation site [posttranslational modification] 1173025008786 intermolecular recognition site; other site 1173025008787 dimerization interface [polypeptide binding]; other site 1173025008788 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025008789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025008790 active site 1173025008791 phosphorylation site [posttranslational modification] 1173025008792 intermolecular recognition site; other site 1173025008793 dimerization interface [polypeptide binding]; other site 1173025008794 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1173025008795 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173025008796 dimerization interface [polypeptide binding]; other site 1173025008797 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1173025008798 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1173025008799 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1173025008800 dimer interface [polypeptide binding]; other site 1173025008801 putative CheW interface [polypeptide binding]; other site 1173025008802 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173025008803 putative binding surface; other site 1173025008804 active site 1173025008805 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1173025008806 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025008807 ATP binding site [chemical binding]; other site 1173025008808 Mg2+ binding site [ion binding]; other site 1173025008809 G-X-G motif; other site 1173025008810 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1173025008811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025008812 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025008813 active site 1173025008814 phosphorylation site [posttranslational modification] 1173025008815 intermolecular recognition site; other site 1173025008816 dimerization interface [polypeptide binding]; other site 1173025008817 Protein of unknown function (DUF511); Region: DUF511; cl01114 1173025008818 Rio2, N-terminal; Region: Rio2_N; pfam09202 1173025008819 Restriction endonuclease; Region: Mrr_cat; pfam04471 1173025008820 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1173025008821 DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cd04371 1173025008822 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173025008823 phosphopeptide binding site; other site 1173025008824 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173025008825 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173025008826 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173025008827 active site 1173025008828 ATP binding site [chemical binding]; other site 1173025008829 substrate binding site [chemical binding]; other site 1173025008830 activation loop (A-loop); other site 1173025008831 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025008832 TPR repeat; Region: TPR_11; pfam13414 1173025008833 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025008834 binding surface 1173025008835 TPR motif; other site 1173025008836 TPR repeat; Region: TPR_11; pfam13414 1173025008837 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025008838 binding surface 1173025008839 TPR motif; other site 1173025008840 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1173025008841 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1173025008842 homodimer interface [polypeptide binding]; other site 1173025008843 substrate-cofactor binding pocket; other site 1173025008844 catalytic residue [active] 1173025008845 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1173025008846 2-isopropylmalate synthase; Validated; Region: PRK00915 1173025008847 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1173025008848 active site 1173025008849 catalytic residues [active] 1173025008850 metal binding site [ion binding]; metal-binding site 1173025008851 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1173025008852 LabA_like proteins; Region: LabA; cd10911 1173025008853 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1173025008854 putative metal binding site [ion binding]; other site 1173025008855 CHASE2 domain; Region: CHASE2; pfam05226 1173025008856 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173025008857 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173025008858 active site 1173025008859 ATP binding site [chemical binding]; other site 1173025008860 substrate binding site [chemical binding]; other site 1173025008861 activation loop (A-loop); other site 1173025008862 FecR protein; Region: FecR; pfam04773 1173025008863 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 1173025008864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173025008865 putative PBP binding loops; other site 1173025008866 dimer interface [polypeptide binding]; other site 1173025008867 ABC-ATPase subunit interface; other site 1173025008868 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 1173025008869 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173025008870 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1173025008871 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1173025008872 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1173025008873 Ligand binding site; other site 1173025008874 Putative Catalytic site; other site 1173025008875 DXD motif; other site 1173025008876 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1173025008877 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1173025008878 Ligand binding site; other site 1173025008879 Putative Catalytic site; other site 1173025008880 DXD motif; other site 1173025008881 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1173025008882 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1173025008883 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173025008884 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173025008885 catalytic loop [active] 1173025008886 iron binding site [ion binding]; other site 1173025008887 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 1173025008888 Stage II sporulation protein; Region: SpoIID; pfam08486 1173025008889 ParB-like nuclease domain; Region: ParBc; cl02129 1173025008890 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1173025008891 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1173025008892 dimerization interface [polypeptide binding]; other site 1173025008893 DPS ferroxidase diiron center [ion binding]; other site 1173025008894 ion pore; other site 1173025008895 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173025008896 non-specific DNA binding site [nucleotide binding]; other site 1173025008897 salt bridge; other site 1173025008898 sequence-specific DNA binding site [nucleotide binding]; other site 1173025008899 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 1173025008900 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 1173025008901 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1173025008902 alpha-gamma subunit interface [polypeptide binding]; other site 1173025008903 beta-gamma subunit interface [polypeptide binding]; other site 1173025008904 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1173025008905 gamma-beta subunit interface [polypeptide binding]; other site 1173025008906 alpha-beta subunit interface [polypeptide binding]; other site 1173025008907 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1173025008908 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1173025008909 subunit interactions [polypeptide binding]; other site 1173025008910 active site 1173025008911 flap region; other site 1173025008912 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025008913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025008914 active site 1173025008915 phosphorylation site [posttranslational modification] 1173025008916 intermolecular recognition site; other site 1173025008917 dimerization interface [polypeptide binding]; other site 1173025008918 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025008919 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025008920 dimer interface [polypeptide binding]; other site 1173025008921 phosphorylation site [posttranslational modification] 1173025008922 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025008923 ATP binding site [chemical binding]; other site 1173025008924 Mg2+ binding site [ion binding]; other site 1173025008925 G-X-G motif; other site 1173025008926 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173025008927 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1173025008928 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1173025008929 Moco binding site; other site 1173025008930 metal coordination site [ion binding]; other site 1173025008931 ribosomal protein L32; Validated; Region: rpl32; CHL00152 1173025008932 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 1173025008933 Psb28 protein; Region: Psb28; cl04326 1173025008934 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1173025008935 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1173025008936 putative NAD(P) binding site [chemical binding]; other site 1173025008937 putative active site [active] 1173025008938 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 1173025008939 active site 1173025008940 catalytic site [active] 1173025008941 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 1173025008942 calcium/proton exchanger (cax); Region: cax; TIGR00378 1173025008943 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1173025008944 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1173025008945 Heme NO binding associated; Region: HNOBA; pfam07701 1173025008946 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1173025008947 cyclase homology domain; Region: CHD; cd07302 1173025008948 nucleotidyl binding site; other site 1173025008949 metal binding site [ion binding]; metal-binding site 1173025008950 dimer interface [polypeptide binding]; other site 1173025008951 sucrose synthase; Region: sucr_synth; TIGR02470 1173025008952 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1173025008953 putative ADP-binding pocket [chemical binding]; other site 1173025008954 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1173025008955 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1173025008956 dimerization interface [polypeptide binding]; other site 1173025008957 DPS ferroxidase diiron center [ion binding]; other site 1173025008958 ion pore; other site 1173025008959 TPR repeat; Region: TPR_11; pfam13414 1173025008960 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025008961 binding surface 1173025008962 TPR motif; other site 1173025008963 TPR repeat; Region: TPR_11; pfam13414 1173025008964 TPR repeat; Region: TPR_11; pfam13414 1173025008965 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025008966 binding surface 1173025008967 TPR motif; other site 1173025008968 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173025008969 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173025008970 phosphopeptide binding site; other site 1173025008971 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1173025008972 Homeodomain-like domain; Region: HTH_23; pfam13384 1173025008973 Winged helix-turn helix; Region: HTH_29; pfam13551 1173025008974 Homeodomain-like domain; Region: HTH_32; pfam13565 1173025008975 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 1173025008976 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1173025008977 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1173025008978 active site 1173025008979 Dienelactone hydrolase family; Region: DLH; pfam01738 1173025008980 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1173025008981 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1173025008982 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1173025008983 dimerization interface [polypeptide binding]; other site 1173025008984 substrate binding pocket [chemical binding]; other site 1173025008985 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1173025008986 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 1173025008987 DNA binding residues [nucleotide binding] 1173025008988 dimer interface [polypeptide binding]; other site 1173025008989 metal binding site [ion binding]; metal-binding site 1173025008990 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1173025008991 active site residue [active] 1173025008992 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1173025008993 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1173025008994 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1173025008995 nucleotide binding site [chemical binding]; other site 1173025008996 CTP synthetase; Validated; Region: pyrG; PRK05380 1173025008997 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1173025008998 Catalytic site [active] 1173025008999 active site 1173025009000 UTP binding site [chemical binding]; other site 1173025009001 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1173025009002 active site 1173025009003 putative oxyanion hole; other site 1173025009004 catalytic triad [active] 1173025009005 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1173025009006 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1173025009007 Bacterial SH3 domain; Region: SH3_3; cl17532 1173025009008 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1173025009009 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1173025009010 active site 1173025009011 metal binding site [ion binding]; metal-binding site 1173025009012 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1173025009013 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1173025009014 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 1173025009015 photosystem II protein K; Region: psbK; CHL00047 1173025009016 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1173025009017 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1173025009018 putative C-terminal domain interface [polypeptide binding]; other site 1173025009019 putative GSH binding site (G-site) [chemical binding]; other site 1173025009020 putative dimer interface [polypeptide binding]; other site 1173025009021 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1173025009022 dimer interface [polypeptide binding]; other site 1173025009023 N-terminal domain interface [polypeptide binding]; other site 1173025009024 substrate binding pocket (H-site) [chemical binding]; other site 1173025009025 DNA polymerase III subunit delta'; Validated; Region: PRK07399 1173025009026 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1173025009027 thymidylate kinase; Validated; Region: tmk; PRK00698 1173025009028 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1173025009029 TMP-binding site; other site 1173025009030 ATP-binding site [chemical binding]; other site 1173025009031 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173025009032 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173025009033 phosphopeptide binding site; other site 1173025009034 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1173025009035 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1173025009036 metal-binding site [ion binding] 1173025009037 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173025009038 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1173025009039 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1173025009040 CAAX protease self-immunity; Region: Abi; pfam02517 1173025009041 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1173025009042 catalytic core [active] 1173025009043 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1173025009044 catalytic core [active] 1173025009045 dihydroorotase; Provisional; Region: PRK07369 1173025009046 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1173025009047 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1173025009048 active site 1173025009049 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1173025009050 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1173025009051 Catalytic site [active] 1173025009052 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173025009053 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1173025009054 Probable transposase; Region: OrfB_IS605; pfam01385 1173025009055 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173025009056 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1173025009057 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1173025009058 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1173025009059 hinge; other site 1173025009060 active site 1173025009061 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1173025009062 SelR domain; Region: SelR; pfam01641 1173025009063 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1173025009064 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1173025009065 minor groove reading motif; other site 1173025009066 helix-hairpin-helix signature motif; other site 1173025009067 substrate binding pocket [chemical binding]; other site 1173025009068 active site 1173025009069 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1173025009070 active site 1173025009071 8-oxo-dGMP binding site [chemical binding]; other site 1173025009072 nudix motif; other site 1173025009073 metal binding site [ion binding]; metal-binding site 1173025009074 RNA polymerase sigma factor SigD; Validated; Region: PRK07405 1173025009075 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1173025009076 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173025009077 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1173025009078 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173025009079 DNA binding residues [nucleotide binding] 1173025009080 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1173025009081 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1173025009082 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1173025009083 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1173025009084 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1173025009085 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1173025009086 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1173025009087 IMP binding site; other site 1173025009088 dimer interface [polypeptide binding]; other site 1173025009089 interdomain contacts; other site 1173025009090 partial ornithine binding site; other site 1173025009091 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1173025009092 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1173025009093 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1173025009094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173025009095 dimer interface [polypeptide binding]; other site 1173025009096 conserved gate region; other site 1173025009097 ABC-ATPase subunit interface; other site 1173025009098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173025009099 dimer interface [polypeptide binding]; other site 1173025009100 conserved gate region; other site 1173025009101 putative PBP binding loops; other site 1173025009102 ABC-ATPase subunit interface; other site 1173025009103 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1173025009104 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1173025009105 Walker A/P-loop; other site 1173025009106 ATP binding site [chemical binding]; other site 1173025009107 Q-loop/lid; other site 1173025009108 ABC transporter signature motif; other site 1173025009109 Walker B; other site 1173025009110 D-loop; other site 1173025009111 H-loop/switch region; other site 1173025009112 TOBE domain; Region: TOBE_2; pfam08402 1173025009113 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1173025009114 homotrimer interaction site [polypeptide binding]; other site 1173025009115 putative active site [active] 1173025009116 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1173025009117 nudix motif; other site 1173025009118 4-alpha-glucanotransferase; Provisional; Region: PRK14508 1173025009119 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1173025009120 Helix-turn-helix domain; Region: HTH_25; pfam13413 1173025009121 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1173025009122 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1173025009123 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1173025009124 RNA binding surface [nucleotide binding]; other site 1173025009125 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1173025009126 active site 1173025009127 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173025009128 PAS domain; Region: PAS; smart00091 1173025009129 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025009130 dimer interface [polypeptide binding]; other site 1173025009131 phosphorylation site [posttranslational modification] 1173025009132 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025009133 ATP binding site [chemical binding]; other site 1173025009134 Mg2+ binding site [ion binding]; other site 1173025009135 G-X-G motif; other site 1173025009136 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173025009137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025009138 active site 1173025009139 phosphorylation site [posttranslational modification] 1173025009140 intermolecular recognition site; other site 1173025009141 dimerization interface [polypeptide binding]; other site 1173025009142 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173025009143 DNA binding site [nucleotide binding] 1173025009144 Predicted permeases [General function prediction only]; Region: COG0679 1173025009145 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173025009146 HSP70 interaction site [polypeptide binding]; other site 1173025009147 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 1173025009148 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 1173025009149 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1173025009150 tetramer interface [polypeptide binding]; other site 1173025009151 TPP-binding site [chemical binding]; other site 1173025009152 heterodimer interface [polypeptide binding]; other site 1173025009153 phosphorylation loop region [posttranslational modification] 1173025009154 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1173025009155 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1173025009156 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1173025009157 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 1173025009158 mce related protein; Region: MCE; pfam02470 1173025009159 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1173025009160 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1173025009161 Walker A/P-loop; other site 1173025009162 ATP binding site [chemical binding]; other site 1173025009163 Q-loop/lid; other site 1173025009164 ABC transporter signature motif; other site 1173025009165 Walker B; other site 1173025009166 D-loop; other site 1173025009167 H-loop/switch region; other site 1173025009168 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1173025009169 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1173025009170 phosphate binding site [ion binding]; other site 1173025009171 putative substrate binding pocket [chemical binding]; other site 1173025009172 dimer interface [polypeptide binding]; other site 1173025009173 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1173025009174 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173025009175 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1173025009176 Protein of unknown function DUF262; Region: DUF262; pfam03235 1173025009177 Uncharacterized conserved protein [Function unknown]; Region: COG3472 1173025009178 DNA-sulfur modification-associated; Region: DndB; pfam14072 1173025009179 DGQHR domain; Region: DGQHR; TIGR03187 1173025009180 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1173025009181 Part of AAA domain; Region: AAA_19; pfam13245 1173025009182 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1173025009183 PLD-like domain; Region: PLDc_2; pfam13091 1173025009184 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1173025009185 putative active site [active] 1173025009186 catalytic site [active] 1173025009187 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 1173025009188 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173025009189 FeS/SAM binding site; other site 1173025009190 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1173025009191 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173025009192 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1173025009193 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1173025009194 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1173025009195 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1173025009196 ATP binding site [chemical binding]; other site 1173025009197 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173025009198 ATP-binding site [chemical binding]; other site 1173025009199 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1173025009200 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173025009201 ATP binding site [chemical binding]; other site 1173025009202 putative Mg++ binding site [ion binding]; other site 1173025009203 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173025009204 nucleotide binding region [chemical binding]; other site 1173025009205 ATP-binding site [chemical binding]; other site 1173025009206 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1173025009207 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173025009208 ATP binding site [chemical binding]; other site 1173025009209 putative Mg++ binding site [ion binding]; other site 1173025009210 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173025009211 nucleotide binding region [chemical binding]; other site 1173025009212 ATP-binding site [chemical binding]; other site 1173025009213 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1173025009214 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1173025009215 Ligand Binding Site [chemical binding]; other site 1173025009216 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1173025009217 active site 1173025009218 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173025009219 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1173025009220 active site 1173025009221 DNA binding site [nucleotide binding] 1173025009222 Int/Topo IB signature motif; other site 1173025009223 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1173025009224 TniQ; Region: TniQ; pfam06527 1173025009225 AAA domain; Region: AAA_22; pfam13401 1173025009226 Helix-turn-helix domain; Region: HTH_28; pfam13518 1173025009227 Integrase core domain; Region: rve; pfam00665 1173025009228 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1173025009229 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1173025009230 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1173025009231 dimerization interface [polypeptide binding]; other site 1173025009232 putative ATP binding site [chemical binding]; other site 1173025009233 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1173025009234 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1173025009235 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 1173025009236 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1173025009237 active site 1173025009238 ATP-binding site [chemical binding]; other site 1173025009239 pantoate-binding site; other site 1173025009240 HXXH motif; other site 1173025009241 AAA domain; Region: AAA_17; pfam13207 1173025009242 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1173025009243 CMP-binding site; other site 1173025009244 The sites determining sugar specificity; other site 1173025009245 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1173025009246 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1173025009247 active site 1173025009248 dimer interface [polypeptide binding]; other site 1173025009249 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1173025009250 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1173025009251 active site 1173025009252 FMN binding site [chemical binding]; other site 1173025009253 substrate binding site [chemical binding]; other site 1173025009254 3Fe-4S cluster binding site [ion binding]; other site 1173025009255 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1173025009256 domain interface; other site 1173025009257 AMIN domain; Region: AMIN; pfam11741 1173025009258 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1173025009259 Cupin domain; Region: Cupin_2; cl17218 1173025009260 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1173025009261 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1173025009262 S17 interaction site [polypeptide binding]; other site 1173025009263 S8 interaction site; other site 1173025009264 16S rRNA interaction site [nucleotide binding]; other site 1173025009265 streptomycin interaction site [chemical binding]; other site 1173025009266 23S rRNA interaction site [nucleotide binding]; other site 1173025009267 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1173025009268 30S ribosomal protein S7; Validated; Region: PRK05302 1173025009269 elongation factor G; Reviewed; Region: PRK00007 1173025009270 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1173025009271 G1 box; other site 1173025009272 putative GEF interaction site [polypeptide binding]; other site 1173025009273 GTP/Mg2+ binding site [chemical binding]; other site 1173025009274 Switch I region; other site 1173025009275 G2 box; other site 1173025009276 G3 box; other site 1173025009277 Switch II region; other site 1173025009278 G4 box; other site 1173025009279 G5 box; other site 1173025009280 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1173025009281 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1173025009282 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1173025009283 elongation factor Tu; Region: tufA; CHL00071 1173025009284 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1173025009285 G1 box; other site 1173025009286 GEF interaction site [polypeptide binding]; other site 1173025009287 GTP/Mg2+ binding site [chemical binding]; other site 1173025009288 Switch I region; other site 1173025009289 G2 box; other site 1173025009290 G3 box; other site 1173025009291 Switch II region; other site 1173025009292 G4 box; other site 1173025009293 G5 box; other site 1173025009294 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1173025009295 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1173025009296 Antibiotic Binding Site [chemical binding]; other site 1173025009297 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1173025009298 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1173025009299 prephenate dehydratase; Provisional; Region: PRK11898 1173025009300 Prephenate dehydratase; Region: PDT; pfam00800 1173025009301 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1173025009302 putative L-Phe binding site [chemical binding]; other site 1173025009303 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 1173025009304 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1173025009305 RNA/DNA hybrid binding site [nucleotide binding]; other site 1173025009306 active site 1173025009307 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1173025009308 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1173025009309 homodimer interface [polypeptide binding]; other site 1173025009310 oligonucleotide binding site [chemical binding]; other site 1173025009311 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 1173025009312 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1173025009313 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173025009314 FeS/SAM binding site; other site 1173025009315 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 1173025009316 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 1173025009317 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1173025009318 anti sigma factor interaction site; other site 1173025009319 regulatory phosphorylation site [posttranslational modification]; other site 1173025009320 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1173025009321 CAAX protease self-immunity; Region: Abi; pfam02517 1173025009322 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173025009323 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025009324 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025009325 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173025009326 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025009327 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 1173025009328 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1173025009329 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 1173025009330 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173025009331 FeS/SAM binding site; other site 1173025009332 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 1173025009333 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 1173025009334 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1173025009335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173025009336 dimer interface [polypeptide binding]; other site 1173025009337 conserved gate region; other site 1173025009338 putative PBP binding loops; other site 1173025009339 ABC-ATPase subunit interface; other site 1173025009340 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1173025009341 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173025009342 dimer interface [polypeptide binding]; other site 1173025009343 conserved gate region; other site 1173025009344 putative PBP binding loops; other site 1173025009345 ABC-ATPase subunit interface; other site 1173025009346 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1173025009347 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1173025009348 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1173025009349 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1173025009350 Walker A/P-loop; other site 1173025009351 ATP binding site [chemical binding]; other site 1173025009352 Q-loop/lid; other site 1173025009353 ABC transporter signature motif; other site 1173025009354 Walker B; other site 1173025009355 D-loop; other site 1173025009356 H-loop/switch region; other site 1173025009357 TOBE domain; Region: TOBE_2; pfam08402 1173025009358 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1173025009359 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1173025009360 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1173025009361 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 1173025009362 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1173025009363 active site 1173025009364 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1173025009365 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1173025009366 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173025009367 P-loop; other site 1173025009368 Magnesium ion binding site [ion binding]; other site 1173025009369 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173025009370 Magnesium ion binding site [ion binding]; other site 1173025009371 Protein of unknown function (DUF4090); Region: DUF4090; pfam13319 1173025009372 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1173025009373 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1173025009374 HIGH motif; other site 1173025009375 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1173025009376 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1173025009377 active site 1173025009378 KMSKS motif; other site 1173025009379 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1173025009380 tRNA binding surface [nucleotide binding]; other site 1173025009381 anticodon binding site; other site 1173025009382 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1173025009383 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 1173025009384 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1173025009385 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1173025009386 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1173025009387 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173025009388 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173025009389 metal binding site [ion binding]; metal-binding site 1173025009390 active site 1173025009391 I-site; other site 1173025009392 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1173025009393 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173025009394 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025009395 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1173025009396 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1173025009397 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1173025009398 active site 1173025009399 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1173025009400 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1173025009401 active site 1173025009402 (T/H)XGH motif; other site 1173025009403 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1173025009404 nudix motif; other site 1173025009405 NAD synthetase; Provisional; Region: PRK13981 1173025009406 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1173025009407 multimer interface [polypeptide binding]; other site 1173025009408 active site 1173025009409 catalytic triad [active] 1173025009410 protein interface 1 [polypeptide binding]; other site 1173025009411 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1173025009412 homodimer interface [polypeptide binding]; other site 1173025009413 NAD binding pocket [chemical binding]; other site 1173025009414 ATP binding pocket [chemical binding]; other site 1173025009415 Mg binding site [ion binding]; other site 1173025009416 active-site loop [active] 1173025009417 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025009418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025009419 active site 1173025009420 phosphorylation site [posttranslational modification] 1173025009421 intermolecular recognition site; other site 1173025009422 dimerization interface [polypeptide binding]; other site 1173025009423 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173025009424 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173025009425 metal binding site [ion binding]; metal-binding site 1173025009426 active site 1173025009427 I-site; other site 1173025009428 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1173025009429 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1173025009430 MoaE interaction surface [polypeptide binding]; other site 1173025009431 MoeB interaction surface [polypeptide binding]; other site 1173025009432 thiocarboxylated glycine; other site 1173025009433 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1173025009434 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1173025009435 threonine synthase; Validated; Region: PRK07591 1173025009436 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1173025009437 homodimer interface [polypeptide binding]; other site 1173025009438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173025009439 catalytic residue [active] 1173025009440 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1173025009441 MoaE interaction surface [polypeptide binding]; other site 1173025009442 MoeB interaction surface [polypeptide binding]; other site 1173025009443 thiocarboxylated glycine; other site 1173025009444 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 1173025009445 Peptidase family M48; Region: Peptidase_M48; cl12018 1173025009446 TM2 domain; Region: TM2; cl00984 1173025009447 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 1173025009448 diiron binding motif [ion binding]; other site 1173025009449 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 1173025009450 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1173025009451 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1173025009452 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 1173025009453 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1173025009454 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1173025009455 ring oligomerisation interface [polypeptide binding]; other site 1173025009456 ATP/Mg binding site [chemical binding]; other site 1173025009457 stacking interactions; other site 1173025009458 hinge regions; other site 1173025009459 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1173025009460 oligomerisation interface [polypeptide binding]; other site 1173025009461 mobile loop; other site 1173025009462 roof hairpin; other site 1173025009463 S-layer homology domain; Region: SLH; pfam00395 1173025009464 S-layer homology domain; Region: SLH; pfam00395 1173025009465 S-layer homology domain; Region: SLH; pfam00395 1173025009466 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025009467 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025009468 dimer interface [polypeptide binding]; other site 1173025009469 phosphorylation site [posttranslational modification] 1173025009470 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025009471 ATP binding site [chemical binding]; other site 1173025009472 Mg2+ binding site [ion binding]; other site 1173025009473 G-X-G motif; other site 1173025009474 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 1173025009475 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 1173025009476 Predicted transcriptional regulators [Transcription]; Region: COG1695 1173025009477 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1173025009478 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 1173025009479 Fructosamine kinase; Region: Fructosamin_kin; pfam03881 1173025009480 Phosphotransferase enzyme family; Region: APH; pfam01636 1173025009481 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1173025009482 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1173025009483 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1173025009484 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 1173025009485 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173025009486 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025009487 TPR repeat; Region: TPR_11; pfam13414 1173025009488 binding surface 1173025009489 TPR motif; other site 1173025009490 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025009491 binding surface 1173025009492 TPR repeat; Region: TPR_11; pfam13414 1173025009493 TPR motif; other site 1173025009494 TPR repeat; Region: TPR_11; pfam13414 1173025009495 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025009496 binding surface 1173025009497 TPR motif; other site 1173025009498 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1173025009499 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1173025009500 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1173025009501 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1173025009502 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1173025009503 dimerization interface [polypeptide binding]; other site 1173025009504 domain crossover interface; other site 1173025009505 redox-dependent activation switch; other site 1173025009506 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173025009507 Ligand Binding Site [chemical binding]; other site 1173025009508 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1173025009509 histidinol dehydrogenase; Region: hisD; TIGR00069 1173025009510 NAD binding site [chemical binding]; other site 1173025009511 dimerization interface [polypeptide binding]; other site 1173025009512 product binding site; other site 1173025009513 substrate binding site [chemical binding]; other site 1173025009514 zinc binding site [ion binding]; other site 1173025009515 catalytic residues [active] 1173025009516 ribosomal protein S20; Region: rps20; CHL00102 1173025009517 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1173025009518 active site 1173025009519 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1173025009520 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1173025009521 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1173025009522 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1173025009523 RPB1 interaction site [polypeptide binding]; other site 1173025009524 RPB10 interaction site [polypeptide binding]; other site 1173025009525 RPB11 interaction site [polypeptide binding]; other site 1173025009526 RPB3 interaction site [polypeptide binding]; other site 1173025009527 RPB12 interaction site [polypeptide binding]; other site 1173025009528 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 1173025009529 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1173025009530 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1173025009531 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1173025009532 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1173025009533 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 1173025009534 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1173025009535 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1173025009536 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1173025009537 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1173025009538 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1173025009539 DNA binding site [nucleotide binding] 1173025009540 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1173025009541 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1173025009542 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1173025009543 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1173025009544 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1173025009545 CHASE2 domain; Region: CHASE2; pfam05226 1173025009546 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173025009547 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173025009548 metal binding site [ion binding]; metal-binding site 1173025009549 active site 1173025009550 I-site; other site 1173025009551 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1173025009552 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1173025009553 CHASE2 domain; Region: CHASE2; pfam05226 1173025009554 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173025009555 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173025009556 active site 1173025009557 ATP binding site [chemical binding]; other site 1173025009558 substrate binding site [chemical binding]; other site 1173025009559 activation loop (A-loop); other site 1173025009560 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 1173025009561 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173025009562 Walker A/P-loop; other site 1173025009563 ATP binding site [chemical binding]; other site 1173025009564 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1173025009565 active site 1173025009566 putative DNA-binding cleft [nucleotide binding]; other site 1173025009567 dimer interface [polypeptide binding]; other site 1173025009568 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1173025009569 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1173025009570 RNase E interface [polypeptide binding]; other site 1173025009571 trimer interface [polypeptide binding]; other site 1173025009572 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1173025009573 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1173025009574 RNase E interface [polypeptide binding]; other site 1173025009575 trimer interface [polypeptide binding]; other site 1173025009576 active site 1173025009577 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1173025009578 putative nucleic acid binding region [nucleotide binding]; other site 1173025009579 G-X-X-G motif; other site 1173025009580 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1173025009581 RNA binding site [nucleotide binding]; other site 1173025009582 domain interface; other site 1173025009583 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1173025009584 triosephosphate isomerase; Provisional; Region: PRK14565 1173025009585 substrate binding site [chemical binding]; other site 1173025009586 dimer interface [polypeptide binding]; other site 1173025009587 catalytic triad [active] 1173025009588 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1173025009589 dihydropteroate synthase; Region: DHPS; TIGR01496 1173025009590 substrate binding pocket [chemical binding]; other site 1173025009591 dimer interface [polypeptide binding]; other site 1173025009592 inhibitor binding site; inhibition site 1173025009593 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1173025009594 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1173025009595 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 1173025009596 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 1173025009597 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173025009598 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1173025009599 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1173025009600 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1173025009601 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1173025009602 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1173025009603 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173025009604 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1173025009605 Probable transposase; Region: OrfB_IS605; pfam01385 1173025009606 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173025009607 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1173025009608 active site 1173025009609 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1173025009610 ATP-grasp domain; Region: ATP-grasp; pfam02222 1173025009611 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 1173025009612 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 1173025009613 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1173025009614 AMIN domain; Region: AMIN; pfam11741 1173025009615 Type II secretory pathway, component HofQ [Intracellular trafficking and secretion]; Region: HofQ; COG4796 1173025009616 Secretin and TonB N terminus short domain; Region: STN; pfam07660 1173025009617 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1173025009618 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1173025009619 IHF dimer interface [polypeptide binding]; other site 1173025009620 IHF - DNA interface [nucleotide binding]; other site 1173025009621 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 1173025009622 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1173025009623 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173025009624 homodimer interface [polypeptide binding]; other site 1173025009625 catalytic residue [active] 1173025009626 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1173025009627 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1173025009628 catalytic triad [active] 1173025009629 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1173025009630 nudix motif; other site 1173025009631 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173025009632 pantothenate kinase; Reviewed; Region: PRK13331 1173025009633 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1173025009634 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1173025009635 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1173025009636 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1173025009637 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1173025009638 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1173025009639 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1173025009640 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1173025009641 Cation efflux family; Region: Cation_efflux; cl00316 1173025009642 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1173025009643 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173025009644 motif II; other site 1173025009645 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173025009646 DALR anticodon binding domain; Region: DALR_1; smart00836 1173025009647 anticodon binding site; other site 1173025009648 tRNA binding surface [nucleotide binding]; other site 1173025009649 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173025009650 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1173025009651 putative switch regulator; other site 1173025009652 non-specific DNA interactions [nucleotide binding]; other site 1173025009653 DNA binding site [nucleotide binding] 1173025009654 sequence specific DNA binding site [nucleotide binding]; other site 1173025009655 putative cAMP binding site [chemical binding]; other site 1173025009656 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173025009657 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173025009658 active site 1173025009659 ATP binding site [chemical binding]; other site 1173025009660 substrate binding site [chemical binding]; other site 1173025009661 activation loop (A-loop); other site 1173025009662 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 1173025009663 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1173025009664 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1173025009665 putative dimerization interface [polypeptide binding]; other site 1173025009666 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173025009667 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173025009668 catalytic loop [active] 1173025009669 iron binding site [ion binding]; other site 1173025009670 Phycobilisome protein; Region: Phycobilisome; cl08227 1173025009671 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 1173025009672 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173025009673 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 1173025009674 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1173025009675 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173025009676 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 1173025009677 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1173025009678 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1173025009679 catalytic residues [active] 1173025009680 Predicted membrane protein [Function unknown]; Region: COG4094 1173025009681 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1173025009682 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173025009683 active site 1173025009684 ATP binding site [chemical binding]; other site 1173025009685 substrate binding site [chemical binding]; other site 1173025009686 activation loop (A-loop); other site 1173025009687 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 1173025009688 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 1173025009689 Phycobilisome protein; Region: Phycobilisome; cl08227 1173025009690 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 1173025009691 V4R domain; Region: V4R; pfam02830 1173025009692 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 1173025009693 Cysteine-rich domain; Region: CCG; pfam02754 1173025009694 Cysteine-rich domain; Region: CCG; pfam02754 1173025009695 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 1173025009696 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025009697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025009698 active site 1173025009699 phosphorylation site [posttranslational modification] 1173025009700 intermolecular recognition site; other site 1173025009701 dimerization interface [polypeptide binding]; other site 1173025009702 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 1173025009703 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1173025009704 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1173025009705 GIY-YIG motif/motif A; other site 1173025009706 active site 1173025009707 catalytic site [active] 1173025009708 putative DNA binding site [nucleotide binding]; other site 1173025009709 metal binding site [ion binding]; metal-binding site 1173025009710 UvrB/uvrC motif; Region: UVR; pfam02151 1173025009711 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1173025009712 Helix-hairpin-helix motif; Region: HHH; pfam00633 1173025009713 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812 1173025009714 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1173025009715 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173025009716 active site 1173025009717 Yqey-like protein; Region: YqeY; pfam09424 1173025009718 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173025009719 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173025009720 active site 1173025009721 ATP binding site [chemical binding]; other site 1173025009722 substrate binding site [chemical binding]; other site 1173025009723 activation loop (A-loop); other site 1173025009724 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1173025009725 AAA domain; Region: AAA_26; pfam13500 1173025009726 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1173025009727 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1173025009728 metal binding site [ion binding]; metal-binding site 1173025009729 dimer interface [polypeptide binding]; other site 1173025009730 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173025009731 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1173025009732 active site 1173025009733 metal binding site [ion binding]; metal-binding site 1173025009734 acyl carrier protein; Provisional; Region: acpP; PRK00982 1173025009735 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1173025009736 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1173025009737 dimer interface [polypeptide binding]; other site 1173025009738 active site 1173025009739 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1173025009740 transketolase; Region: PLN02790 1173025009741 TPP-binding site [chemical binding]; other site 1173025009742 dimer interface [polypeptide binding]; other site 1173025009743 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1173025009744 PYR/PP interface [polypeptide binding]; other site 1173025009745 dimer interface [polypeptide binding]; other site 1173025009746 TPP binding site [chemical binding]; other site 1173025009747 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1173025009748 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173025009749 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1173025009750 Probable transposase; Region: OrfB_IS605; pfam01385 1173025009751 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1173025009752 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173025009753 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173025009754 S-adenosylmethionine binding site [chemical binding]; other site 1173025009755 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173025009756 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173025009757 S-layer homology domain; Region: SLH; pfam00395 1173025009758 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1173025009759 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1173025009760 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1173025009761 putative dimer interface [polypeptide binding]; other site 1173025009762 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1173025009763 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1173025009764 nucleotide binding site [chemical binding]; other site 1173025009765 NEF interaction site [polypeptide binding]; other site 1173025009766 SBD interface [polypeptide binding]; other site 1173025009767 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 1173025009768 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173025009769 dimerization interface [polypeptide binding]; other site 1173025009770 PAS fold; Region: PAS_4; pfam08448 1173025009771 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025009772 putative active site [active] 1173025009773 heme pocket [chemical binding]; other site 1173025009774 GAF domain; Region: GAF; cl17456 1173025009775 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173025009776 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025009777 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173025009778 putative active site [active] 1173025009779 heme pocket [chemical binding]; other site 1173025009780 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025009781 putative active site [active] 1173025009782 heme pocket [chemical binding]; other site 1173025009783 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1173025009784 cyclase homology domain; Region: CHD; cd07302 1173025009785 nucleotidyl binding site; other site 1173025009786 metal binding site [ion binding]; metal-binding site 1173025009787 dimer interface [polypeptide binding]; other site 1173025009788 MASE1; Region: MASE1; cl17823 1173025009789 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173025009790 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025009791 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173025009792 putative active site [active] 1173025009793 heme pocket [chemical binding]; other site 1173025009794 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173025009795 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025009796 putative active site [active] 1173025009797 heme pocket [chemical binding]; other site 1173025009798 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025009799 putative active site [active] 1173025009800 heme pocket [chemical binding]; other site 1173025009801 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173025009802 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025009803 putative active site [active] 1173025009804 heme pocket [chemical binding]; other site 1173025009805 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025009806 dimer interface [polypeptide binding]; other site 1173025009807 phosphorylation site [posttranslational modification] 1173025009808 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025009809 ATP binding site [chemical binding]; other site 1173025009810 Mg2+ binding site [ion binding]; other site 1173025009811 G-X-G motif; other site 1173025009812 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025009813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025009814 active site 1173025009815 phosphorylation site [posttranslational modification] 1173025009816 intermolecular recognition site; other site 1173025009817 dimerization interface [polypeptide binding]; other site 1173025009818 carotene isomerase; Region: carot_isom; TIGR02730 1173025009819 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173025009820 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1173025009821 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1173025009822 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1173025009823 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1173025009824 Repair protein; Region: Repair_PSII; pfam04536 1173025009825 L-aspartate oxidase; Provisional; Region: PRK06175 1173025009826 L-aspartate oxidase; Provisional; Region: PRK07395 1173025009827 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1173025009828 photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515 1173025009829 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173025009830 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173025009831 phosphopeptide binding site; other site 1173025009832 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173025009833 cyclase homology domain; Region: CHD; cd07302 1173025009834 nucleotidyl binding site; other site 1173025009835 metal binding site [ion binding]; metal-binding site 1173025009836 dimer interface [polypeptide binding]; other site 1173025009837 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 1173025009838 Bacitracin resistance protein BacA; Region: BacA; pfam02673 1173025009839 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1173025009840 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 1173025009841 Protein of unknown function (DUF512); Region: DUF512; pfam04459 1173025009842 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1173025009843 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1173025009844 putative homodimer interface [polypeptide binding]; other site 1173025009845 putative active site pocket [active] 1173025009846 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1173025009847 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 1173025009848 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1173025009849 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1173025009850 active site 1173025009851 HIGH motif; other site 1173025009852 dimer interface [polypeptide binding]; other site 1173025009853 KMSKS motif; other site 1173025009854 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1173025009855 FAD binding site [chemical binding]; other site 1173025009856 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1173025009857 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 1173025009858 lycopene cyclase; Region: lycopene_cycl; TIGR01789 1173025009859 arginine decarboxylase; Provisional; Region: PRK05354 1173025009860 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1173025009861 dimer interface [polypeptide binding]; other site 1173025009862 active site 1173025009863 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1173025009864 catalytic residues [active] 1173025009865 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1173025009866 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1173025009867 active site 1173025009868 multimer interface [polypeptide binding]; other site 1173025009869 Integral membrane protein TerC family; Region: TerC; cl10468 1173025009870 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1173025009871 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1173025009872 nucleotide binding site [chemical binding]; other site 1173025009873 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1173025009874 SBD interface [polypeptide binding]; other site 1173025009875 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1173025009876 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1173025009877 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1173025009878 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1173025009879 active site 1173025009880 intersubunit interface [polypeptide binding]; other site 1173025009881 catalytic residue [active] 1173025009882 FtsH Extracellular; Region: FtsH_ext; pfam06480 1173025009883 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1173025009884 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173025009885 Walker A motif; other site 1173025009886 ATP binding site [chemical binding]; other site 1173025009887 Walker B motif; other site 1173025009888 arginine finger; other site 1173025009889 Peptidase family M41; Region: Peptidase_M41; pfam01434 1173025009890 FtsH Extracellular; Region: FtsH_ext; pfam06480 1173025009891 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1173025009892 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 1173025009893 homodimer interface [polypeptide binding]; other site 1173025009894 substrate-cofactor binding pocket; other site 1173025009895 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173025009896 catalytic residue [active] 1173025009897 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173025009898 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173025009899 phosphopeptide binding site; other site 1173025009900 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1173025009901 Transglycosylase; Region: Transgly; pfam00912 1173025009902 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1173025009903 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 1173025009904 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1173025009905 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 1173025009906 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 1173025009907 G1 box; other site 1173025009908 GTP/Mg2+ binding site [chemical binding]; other site 1173025009909 Switch I region; other site 1173025009910 G2 box; other site 1173025009911 Switch II region; other site 1173025009912 G3 box; other site 1173025009913 G4 box; other site 1173025009914 Domain of unknown function (DUF697); Region: DUF697; pfam05128 1173025009915 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1173025009916 metal binding site 2 [ion binding]; metal-binding site 1173025009917 putative DNA binding helix; other site 1173025009918 metal binding site 1 [ion binding]; metal-binding site 1173025009919 dimer interface [polypeptide binding]; other site 1173025009920 structural Zn2+ binding site [ion binding]; other site 1173025009921 Domain of unknown function (DUF1817); Region: DUF1817; pfam08847 1173025009922 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1173025009923 Peptidase family M23; Region: Peptidase_M23; pfam01551 1173025009924 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173025009925 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1173025009926 Probable transposase; Region: OrfB_IS605; pfam01385 1173025009927 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1173025009928 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 1173025009929 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 1173025009930 MltA specific insert domain; Region: MltA; pfam03562 1173025009931 3D domain; Region: 3D; pfam06725 1173025009932 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1173025009933 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1173025009934 TrkA-N domain; Region: TrkA_N; pfam02254 1173025009935 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1173025009936 homodimer interface [polypeptide binding]; other site 1173025009937 active site 1173025009938 SAM binding site [chemical binding]; other site 1173025009939 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1173025009940 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1173025009941 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1173025009942 putative ribose interaction site [chemical binding]; other site 1173025009943 putative ADP binding site [chemical binding]; other site 1173025009944 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1173025009945 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1173025009946 NAD binding site [chemical binding]; other site 1173025009947 substrate binding site [chemical binding]; other site 1173025009948 homodimer interface [polypeptide binding]; other site 1173025009949 active site 1173025009950 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1173025009951 metal ion-dependent adhesion site (MIDAS); other site 1173025009952 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1173025009953 DHH family; Region: DHH; pfam01368 1173025009954 DHHA1 domain; Region: DHHA1; pfam02272 1173025009955 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1173025009956 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1173025009957 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 1173025009958 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 1173025009959 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 1173025009960 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 1173025009961 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 1173025009962 Predicted membrane protein [Function unknown]; Region: COG1981 1173025009963 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1173025009964 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1173025009965 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1173025009966 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1173025009967 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173025009968 ATP binding site [chemical binding]; other site 1173025009969 putative Mg++ binding site [ion binding]; other site 1173025009970 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173025009971 nucleotide binding region [chemical binding]; other site 1173025009972 ATP-binding site [chemical binding]; other site 1173025009973 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1173025009974 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1173025009975 CHASE2 domain; Region: CHASE2; pfam05226 1173025009976 PAS fold; Region: PAS_4; pfam08448 1173025009977 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025009978 putative active site [active] 1173025009979 heme pocket [chemical binding]; other site 1173025009980 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173025009981 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173025009982 metal binding site [ion binding]; metal-binding site 1173025009983 active site 1173025009984 I-site; other site 1173025009985 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 1173025009986 putative active site [active] 1173025009987 substrate binding site [chemical binding]; other site 1173025009988 redox center [active] 1173025009989 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1173025009990 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cd04722 1173025009991 phosphate binding site [ion binding]; other site 1173025009992 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 1173025009993 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1173025009994 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173025009995 FeS/SAM binding site; other site 1173025009996 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1173025009997 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1173025009998 ATP binding site [chemical binding]; other site 1173025009999 Mg++ binding site [ion binding]; other site 1173025010000 motif III; other site 1173025010001 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173025010002 nucleotide binding region [chemical binding]; other site 1173025010003 ATP-binding site [chemical binding]; other site 1173025010004 PUCC protein; Region: PUCC; pfam03209 1173025010005 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173025010006 putative substrate translocation pore; other site 1173025010007 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1173025010008 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 1173025010009 active site 1173025010010 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1173025010011 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1173025010012 Walker A/P-loop; other site 1173025010013 ATP binding site [chemical binding]; other site 1173025010014 Q-loop/lid; other site 1173025010015 ABC transporter signature motif; other site 1173025010016 Walker B; other site 1173025010017 D-loop; other site 1173025010018 H-loop/switch region; other site 1173025010019 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1173025010020 DevC protein; Region: devC; TIGR01185 1173025010021 FtsX-like permease family; Region: FtsX; pfam02687 1173025010022 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 1173025010023 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1173025010024 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1173025010025 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1173025010026 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1173025010027 putative NAD(P) binding site [chemical binding]; other site 1173025010028 putative substrate binding site [chemical binding]; other site 1173025010029 catalytic Zn binding site [ion binding]; other site 1173025010030 structural Zn binding site [ion binding]; other site 1173025010031 dimer interface [polypeptide binding]; other site 1173025010032 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1173025010033 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1173025010034 dimer interface [polypeptide binding]; other site 1173025010035 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173025010036 catalytic residue [active] 1173025010037 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1173025010038 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 1173025010039 dimer interface [polypeptide binding]; other site 1173025010040 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1173025010041 catalytic triad [active] 1173025010042 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173025010043 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1173025010044 Probable transposase; Region: OrfB_IS605; pfam01385 1173025010045 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173025010046 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 1173025010047 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1173025010048 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 1173025010049 putative NADP binding site [chemical binding]; other site 1173025010050 putative substrate binding site [chemical binding]; other site 1173025010051 active site 1173025010052 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1173025010053 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1173025010054 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173025010055 catalytic residue [active] 1173025010056 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1173025010057 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1173025010058 [2Fe-2S] cluster binding site [ion binding]; other site 1173025010059 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1173025010060 hydrophobic ligand binding site; other site 1173025010061 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173025010062 putative substrate translocation pore; other site 1173025010063 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173025010064 GH3 auxin-responsive promoter; Region: GH3; pfam03321 1173025010065 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1173025010066 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173025010067 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1173025010068 protein binding site [polypeptide binding]; other site 1173025010069 Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158 1173025010070 putative homodimer interface [polypeptide binding]; other site 1173025010071 putative homotetramer interface [polypeptide binding]; other site 1173025010072 putative metal binding site [ion binding]; other site 1173025010073 putative homodimer-homodimer interface [polypeptide binding]; other site 1173025010074 putative allosteric switch controlling residues; other site 1173025010075 CHASE domain; Region: CHASE; pfam03924 1173025010076 PAS domain S-box; Region: sensory_box; TIGR00229 1173025010077 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025010078 putative active site [active] 1173025010079 heme pocket [chemical binding]; other site 1173025010080 PAS domain; Region: PAS; smart00091 1173025010081 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173025010082 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1173025010083 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025010084 putative active site [active] 1173025010085 heme pocket [chemical binding]; other site 1173025010086 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025010087 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025010088 dimer interface [polypeptide binding]; other site 1173025010089 phosphorylation site [posttranslational modification] 1173025010090 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025010091 ATP binding site [chemical binding]; other site 1173025010092 Mg2+ binding site [ion binding]; other site 1173025010093 G-X-G motif; other site 1173025010094 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173025010095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025010096 active site 1173025010097 phosphorylation site [posttranslational modification] 1173025010098 intermolecular recognition site; other site 1173025010099 dimerization interface [polypeptide binding]; other site 1173025010100 acetyl-CoA synthetase; Provisional; Region: PRK00174 1173025010101 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1173025010102 active site 1173025010103 CoA binding site [chemical binding]; other site 1173025010104 acyl-activating enzyme (AAE) consensus motif; other site 1173025010105 AMP binding site [chemical binding]; other site 1173025010106 acetate binding site [chemical binding]; other site 1173025010107 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1173025010108 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1173025010109 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1173025010110 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1173025010111 Cupin domain; Region: Cupin_2; cl17218 1173025010112 Predicted membrane protein [Function unknown]; Region: COG2246 1173025010113 GtrA-like protein; Region: GtrA; pfam04138 1173025010114 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1173025010115 Protein of unknown function (DUF962); Region: DUF962; pfam06127 1173025010116 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1173025010117 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173025010118 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173025010119 S-adenosylmethionine binding site [chemical binding]; other site 1173025010120 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1173025010121 Ligand binding site; other site 1173025010122 Putative Catalytic site; other site 1173025010123 DXD motif; other site 1173025010124 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 1173025010125 hypothetical protein; Provisional; Region: PRK07208 1173025010126 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173025010127 Predicted membrane protein [Function unknown]; Region: COG2246 1173025010128 GtrA-like protein; Region: GtrA; pfam04138 1173025010129 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1173025010130 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1173025010131 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1173025010132 substrate binding site [chemical binding]; other site 1173025010133 ATP binding site [chemical binding]; other site 1173025010134 Predicted methyltransferases [General function prediction only]; Region: COG0313 1173025010135 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1173025010136 putative SAM binding site [chemical binding]; other site 1173025010137 putative homodimer interface [polypeptide binding]; other site 1173025010138 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1173025010139 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 1173025010140 active site 1173025010141 substrate binding site [chemical binding]; other site 1173025010142 metal binding site [ion binding]; metal-binding site 1173025010143 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1173025010144 DNA-binding interface [nucleotide binding]; DNA binding site 1173025010145 Domain of unknown function DUF21; Region: DUF21; pfam01595 1173025010146 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1173025010147 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173025010148 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173025010149 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173025010150 Walker A/P-loop; other site 1173025010151 ATP binding site [chemical binding]; other site 1173025010152 Q-loop/lid; other site 1173025010153 ABC transporter signature motif; other site 1173025010154 Walker B; other site 1173025010155 D-loop; other site 1173025010156 H-loop/switch region; other site 1173025010157 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1173025010158 active site 1173025010159 catalytic triad [active] 1173025010160 oxyanion hole [active] 1173025010161 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1173025010162 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1173025010163 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1173025010164 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1173025010165 Ligand Binding Site [chemical binding]; other site 1173025010166 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1173025010167 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1173025010168 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1173025010169 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1173025010170 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1173025010171 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1173025010172 Domain of unknown function DUF21; Region: DUF21; pfam01595 1173025010173 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1173025010174 Transporter associated domain; Region: CorC_HlyC; smart01091 1173025010175 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173025010176 active site 1173025010177 SnoaL-like domain; Region: SnoaL_2; pfam12680 1173025010178 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 1173025010179 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 1173025010180 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 1173025010181 PAS domain S-box; Region: sensory_box; TIGR00229 1173025010182 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025010183 putative active site [active] 1173025010184 heme pocket [chemical binding]; other site 1173025010185 PAS domain S-box; Region: sensory_box; TIGR00229 1173025010186 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025010187 putative active site [active] 1173025010188 heme pocket [chemical binding]; other site 1173025010189 PAS domain; Region: PAS_9; pfam13426 1173025010190 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025010191 putative active site [active] 1173025010192 heme pocket [chemical binding]; other site 1173025010193 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025010194 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173025010195 putative active site [active] 1173025010196 heme pocket [chemical binding]; other site 1173025010197 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025010198 dimer interface [polypeptide binding]; other site 1173025010199 phosphorylation site [posttranslational modification] 1173025010200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025010201 ATP binding site [chemical binding]; other site 1173025010202 Mg2+ binding site [ion binding]; other site 1173025010203 G-X-G motif; other site 1173025010204 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1173025010205 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1173025010206 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1173025010207 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1173025010208 hypothetical protein; Validated; Region: PRK07413 1173025010209 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1173025010210 Walker A motif; other site 1173025010211 homodimer interface [polypeptide binding]; other site 1173025010212 ATP binding site [chemical binding]; other site 1173025010213 hydroxycobalamin binding site [chemical binding]; other site 1173025010214 Walker B motif; other site 1173025010215 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1173025010216 Walker A motif; other site 1173025010217 homodimer interface [polypeptide binding]; other site 1173025010218 ATP binding site [chemical binding]; other site 1173025010219 hydroxycobalamin binding site [chemical binding]; other site 1173025010220 Walker B motif; other site 1173025010221 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173025010222 Coenzyme A binding pocket [chemical binding]; other site 1173025010223 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1173025010224 hypothetical protein; Reviewed; Region: PRK09588 1173025010225 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1173025010226 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1173025010227 active site 1173025010228 dimer interface [polypeptide binding]; other site 1173025010229 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 1173025010230 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1173025010231 active site 1173025010232 catalytic tetrad [active] 1173025010233 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1173025010234 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1173025010235 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173025010236 S-adenosylmethionine binding site [chemical binding]; other site 1173025010237 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1173025010238 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1173025010239 Walker A/P-loop; other site 1173025010240 ATP binding site [chemical binding]; other site 1173025010241 Q-loop/lid; other site 1173025010242 ABC transporter signature motif; other site 1173025010243 Walker B; other site 1173025010244 D-loop; other site 1173025010245 H-loop/switch region; other site 1173025010246 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025010247 TPR motif; other site 1173025010248 binding surface 1173025010249 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 1173025010250 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 1173025010251 nudix motif; other site 1173025010252 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1173025010253 MPT binding site; other site 1173025010254 trimer interface [polypeptide binding]; other site 1173025010255 photosystem II reaction center protein Psb28; Provisional; Region: PRK13612 1173025010256 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1173025010257 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1173025010258 NAD(P) binding site [chemical binding]; other site 1173025010259 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1173025010260 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1173025010261 inhibitor-cofactor binding pocket; inhibition site 1173025010262 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173025010263 catalytic residue [active] 1173025010264 cyanoexosortase B; Region: cyanoexo_CrtB; TIGR04156 1173025010265 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 1173025010266 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 1173025010267 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1173025010268 SLBB domain; Region: SLBB; pfam10531 1173025010269 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1173025010270 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173025010271 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1173025010272 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1173025010273 Nucleotide binding site [chemical binding]; other site 1173025010274 P loop; other site 1173025010275 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1173025010276 catalytic residue [active] 1173025010277 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1173025010278 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1173025010279 NAD(P) binding site [chemical binding]; other site 1173025010280 putative active site [active] 1173025010281 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 1173025010282 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173025010283 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1173025010284 Probable transposase; Region: OrfB_IS605; pfam01385 1173025010285 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173025010286 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 1173025010287 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1173025010288 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1173025010289 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1173025010290 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1173025010291 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1173025010292 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1173025010293 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1173025010294 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1173025010295 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1173025010296 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173025010297 Coenzyme A binding pocket [chemical binding]; other site 1173025010298 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 1173025010299 Na binding site [ion binding]; other site 1173025010300 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1173025010301 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1173025010302 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1173025010303 Catalytic site [active] 1173025010304 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173025010305 active site 1173025010306 YGGT family; Region: YGGT; pfam02325 1173025010307 Cache domain; Region: Cache_1; pfam02743 1173025010308 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173025010309 dimerization interface [polypeptide binding]; other site 1173025010310 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025010311 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173025010312 putative active site [active] 1173025010313 heme pocket [chemical binding]; other site 1173025010314 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1173025010315 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025010316 putative active site [active] 1173025010317 heme pocket [chemical binding]; other site 1173025010318 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 1173025010319 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025010320 dimer interface [polypeptide binding]; other site 1173025010321 phosphorylation site [posttranslational modification] 1173025010322 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025010323 ATP binding site [chemical binding]; other site 1173025010324 Mg2+ binding site [ion binding]; other site 1173025010325 G-X-G motif; other site 1173025010326 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1173025010327 Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria; Region: PBP1_BmpA_like; cd06304 1173025010328 ligand binding site [chemical binding]; other site 1173025010329 Mg chelatase-related protein; Region: TIGR00368 1173025010330 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1173025010331 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173025010332 Walker A motif; other site 1173025010333 ATP binding site [chemical binding]; other site 1173025010334 Walker B motif; other site 1173025010335 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1173025010336 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1173025010337 nucleotide binding site/active site [active] 1173025010338 HIT family signature motif; other site 1173025010339 catalytic residue [active] 1173025010340 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 1173025010341 protein I interface; other site 1173025010342 D2 interface; other site 1173025010343 protein T interface; other site 1173025010344 chlorophyll binding site; other site 1173025010345 beta carotene binding site; other site 1173025010346 pheophytin binding site; other site 1173025010347 manganese-stabilizing polypeptide interface; other site 1173025010348 CP43 interface; other site 1173025010349 protein L interface; other site 1173025010350 oxygen evolving complex binding site; other site 1173025010351 bromide binding site; other site 1173025010352 quinone binding site; other site 1173025010353 Fe binding site [ion binding]; other site 1173025010354 core light harvesting interface; other site 1173025010355 cytochrome b559 alpha subunit interface; other site 1173025010356 cytochrome c-550 interface; other site 1173025010357 protein J interface; other site 1173025010358 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173025010359 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173025010360 S-adenosylmethionine binding site [chemical binding]; other site 1173025010361 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173025010362 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173025010363 active site 1173025010364 ATP binding site [chemical binding]; other site 1173025010365 substrate binding site [chemical binding]; other site 1173025010366 activation loop (A-loop); other site 1173025010367 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1173025010368 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1173025010369 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1173025010370 shikimate binding site; other site 1173025010371 NAD(P) binding site [chemical binding]; other site 1173025010372 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1173025010373 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1173025010374 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1173025010375 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 1173025010376 putative NAD(P) binding site [chemical binding]; other site 1173025010377 active site 1173025010378 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1173025010379 Glycoprotease family; Region: Peptidase_M22; pfam00814 1173025010380 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1173025010381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173025010382 dimer interface [polypeptide binding]; other site 1173025010383 conserved gate region; other site 1173025010384 putative PBP binding loops; other site 1173025010385 ABC-ATPase subunit interface; other site 1173025010386 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1173025010387 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1173025010388 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 1173025010389 maltose O-acetyltransferase; Provisional; Region: PRK10092 1173025010390 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1173025010391 active site 1173025010392 substrate binding site [chemical binding]; other site 1173025010393 trimer interface [polypeptide binding]; other site 1173025010394 CoA binding site [chemical binding]; other site 1173025010395 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1173025010396 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1173025010397 active site 1173025010398 catalytic tetrad [active] 1173025010399 threonine dehydratase; Reviewed; Region: PRK09224 1173025010400 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1173025010401 tetramer interface [polypeptide binding]; other site 1173025010402 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173025010403 catalytic residue [active] 1173025010404 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1173025010405 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1173025010406 putative Ile/Val binding site [chemical binding]; other site 1173025010407 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173025010408 active site 1173025010409 ATP binding site [chemical binding]; other site 1173025010410 substrate binding site [chemical binding]; other site 1173025010411 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173025010412 activation loop (A-loop); other site 1173025010413 AAA ATPase domain; Region: AAA_16; pfam13191 1173025010414 Predicted ATPase [General function prediction only]; Region: COG3899 1173025010415 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025010416 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025010417 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025010418 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025010419 dimer interface [polypeptide binding]; other site 1173025010420 phosphorylation site [posttranslational modification] 1173025010421 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025010422 ATP binding site [chemical binding]; other site 1173025010423 Mg2+ binding site [ion binding]; other site 1173025010424 G-X-G motif; other site 1173025010425 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1173025010426 G1 box; other site 1173025010427 GTP/Mg2+ binding site [chemical binding]; other site 1173025010428 G2 box; other site 1173025010429 Switch I region; other site 1173025010430 G3 box; other site 1173025010431 Switch II region; other site 1173025010432 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 1173025010433 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 1173025010434 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1173025010435 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173025010436 Coenzyme A binding pocket [chemical binding]; other site 1173025010437 PAS domain; Region: PAS_8; pfam13188 1173025010438 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173025010439 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173025010440 metal binding site [ion binding]; metal-binding site 1173025010441 active site 1173025010442 I-site; other site 1173025010443 Predicted GTPase [General function prediction only]; Region: COG3596 1173025010444 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173025010445 YfjP GTPase; Region: YfjP; cd11383 1173025010446 G1 box; other site 1173025010447 Walker A/P-loop; other site 1173025010448 GTP/Mg2+ binding site [chemical binding]; other site 1173025010449 ATP binding site [chemical binding]; other site 1173025010450 Switch I region; other site 1173025010451 G2 box; other site 1173025010452 Switch II region; other site 1173025010453 G3 box; other site 1173025010454 G4 box; other site 1173025010455 HEAT-like repeat; Region: HEAT_EZ; pfam13513 1173025010456 HEAT repeat; Region: HEAT; pfam02985 1173025010457 HEAT repeats; Region: HEAT_2; pfam13646 1173025010458 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1173025010459 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173025010460 photosystem I P700 chlorophyll a apoprotein A2; Region: psaB; CHL00054 1173025010461 photosystem I P700 chlorophyll a apoprotein A1; Region: psaA; CHL00056 1173025010462 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1173025010463 PHP domain; Region: PHP; pfam02811 1173025010464 active site 1173025010465 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173025010466 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025010467 active site 1173025010468 phosphorylation site [posttranslational modification] 1173025010469 intermolecular recognition site; other site 1173025010470 dimerization interface [polypeptide binding]; other site 1173025010471 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173025010472 DNA binding residues [nucleotide binding] 1173025010473 dimerization interface [polypeptide binding]; other site 1173025010474 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173025010475 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173025010476 active site 1173025010477 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1173025010478 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1173025010479 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1173025010480 active site 1173025010481 homodimer interface [polypeptide binding]; other site 1173025010482 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1173025010483 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1173025010484 Walker A motif; other site 1173025010485 ATP binding site [chemical binding]; other site 1173025010486 Walker B motif; other site 1173025010487 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 1173025010488 tetramer interface [polypeptide binding]; other site 1173025010489 dimer interface [polypeptide binding]; other site 1173025010490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173025010491 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173025010492 putative substrate translocation pore; other site 1173025010493 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1173025010494 trimer interface [polypeptide binding]; other site 1173025010495 dimer interface [polypeptide binding]; other site 1173025010496 putative active site [active] 1173025010497 2TM domain; Region: 2TM; pfam13239 1173025010498 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 1173025010499 integral membrane protein MviN; Region: mviN; TIGR01695 1173025010500 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1173025010501 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1173025010502 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 1173025010503 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173025010504 putative binding surface; other site 1173025010505 active site 1173025010506 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 1173025010507 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1173025010508 PYR/PP interface [polypeptide binding]; other site 1173025010509 dimer interface [polypeptide binding]; other site 1173025010510 TPP binding site [chemical binding]; other site 1173025010511 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1173025010512 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1173025010513 TPP-binding site [chemical binding]; other site 1173025010514 dimer interface [polypeptide binding]; other site 1173025010515 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1173025010516 H+ Antiporter protein; Region: 2A0121; TIGR00900 1173025010517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173025010518 CHASE3 domain; Region: CHASE3; pfam05227 1173025010519 PAS domain; Region: PAS_9; pfam13426 1173025010520 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025010521 putative active site [active] 1173025010522 heme pocket [chemical binding]; other site 1173025010523 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025010524 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025010525 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173025010526 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173025010527 metal binding site [ion binding]; metal-binding site 1173025010528 active site 1173025010529 I-site; other site 1173025010530 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 1173025010531 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1173025010532 C-terminal domain interface [polypeptide binding]; other site 1173025010533 active site 1173025010534 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1173025010535 active site 1173025010536 N-terminal domain interface [polypeptide binding]; other site 1173025010537 Predicted flavoprotein [General function prediction only]; Region: COG0431 1173025010538 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1173025010539 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1173025010540 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173025010541 Walker A motif; other site 1173025010542 ATP binding site [chemical binding]; other site 1173025010543 Walker B motif; other site 1173025010544 arginine finger; other site 1173025010545 Peptidase family M41; Region: Peptidase_M41; pfam01434 1173025010546 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 1173025010547 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173025010548 active site 1173025010549 motif I; other site 1173025010550 motif II; other site 1173025010551 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1173025010552 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1173025010553 putative active site [active] 1173025010554 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1173025010555 substrate binding site; other site 1173025010556 dimer interface; other site 1173025010557 acetylornithine aminotransferase; Provisional; Region: PRK02627 1173025010558 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1173025010559 inhibitor-cofactor binding pocket; inhibition site 1173025010560 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173025010561 catalytic residue [active] 1173025010562 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025010563 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025010564 dimer interface [polypeptide binding]; other site 1173025010565 phosphorylation site [posttranslational modification] 1173025010566 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025010567 ATP binding site [chemical binding]; other site 1173025010568 Mg2+ binding site [ion binding]; other site 1173025010569 G-X-G motif; other site 1173025010570 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025010571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025010572 active site 1173025010573 phosphorylation site [posttranslational modification] 1173025010574 intermolecular recognition site; other site 1173025010575 dimerization interface [polypeptide binding]; other site 1173025010576 KaiA domain; Region: KaiA; pfam07688 1173025010577 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 1173025010578 tetramer interface [polypeptide binding]; other site 1173025010579 dimer interface [polypeptide binding]; other site 1173025010580 circadian clock protein KaiC; Region: circ_KaiC; TIGR02655 1173025010581 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 1173025010582 Walker A motif; other site 1173025010583 ATP binding site [chemical binding]; other site 1173025010584 Walker B motif; other site 1173025010585 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1173025010586 ATP binding site [chemical binding]; other site 1173025010587 Walker B motif; other site 1173025010588 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1173025010589 Peptidase family M23; Region: Peptidase_M23; pfam01551 1173025010590 Uncharacterized conserved protein [Function unknown]; Region: COG2836 1173025010591 cytochrome c6; Provisional; Region: PRK13697 1173025010592 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1173025010593 Predicted transcriptional regulator [Transcription]; Region: COG3682 1173025010594 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1173025010595 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1173025010596 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1173025010597 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1173025010598 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1173025010599 signal recognition particle protein; Provisional; Region: PRK10867 1173025010600 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1173025010601 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1173025010602 GTP binding site [chemical binding]; other site 1173025010603 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1173025010604 GAF domain; Region: GAF; cl17456 1173025010605 GAF domain; Region: GAF_2; pfam13185 1173025010606 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1173025010607 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173025010608 ATP binding site [chemical binding]; other site 1173025010609 putative Mg++ binding site [ion binding]; other site 1173025010610 nucleotide binding region [chemical binding]; other site 1173025010611 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1173025010612 ATP-binding site [chemical binding]; other site 1173025010613 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 1173025010614 nudix motif; other site 1173025010615 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 1173025010616 PLD-like domain; Region: PLDc_2; pfam13091 1173025010617 putative active site [active] 1173025010618 catalytic site [active] 1173025010619 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 1173025010620 PLD-like domain; Region: PLDc_2; pfam13091 1173025010621 putative active site [active] 1173025010622 catalytic site [active] 1173025010623 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 1173025010624 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 1173025010625 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12567 1173025010626 hypothetical protein; Provisional; Region: PRK07377 1173025010627 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334 1173025010628 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234 1173025010629 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173025010630 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08389 1173025010631 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1173025010632 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1173025010633 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1173025010634 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1173025010635 catalytic triad [active] 1173025010636 shikimate kinase; Reviewed; Region: aroK; PRK00131 1173025010637 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1173025010638 ADP binding site [chemical binding]; other site 1173025010639 magnesium binding site [ion binding]; other site 1173025010640 putative shikimate binding site; other site 1173025010641 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1173025010642 feedback inhibition sensing region; other site 1173025010643 homohexameric interface [polypeptide binding]; other site 1173025010644 nucleotide binding site [chemical binding]; other site 1173025010645 N-acetyl-L-glutamate binding site [chemical binding]; other site 1173025010646 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025010647 GAF domain; Region: GAF; pfam01590 1173025010648 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025010649 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025010650 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025010651 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025010652 dimer interface [polypeptide binding]; other site 1173025010653 phosphorylation site [posttranslational modification] 1173025010654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025010655 ATP binding site [chemical binding]; other site 1173025010656 Mg2+ binding site [ion binding]; other site 1173025010657 G-X-G motif; other site 1173025010658 glycogen branching enzyme; Provisional; Region: PRK05402 1173025010659 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1173025010660 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1173025010661 active site 1173025010662 catalytic site [active] 1173025010663 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1173025010664 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1173025010665 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1173025010666 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1173025010667 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1173025010668 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1173025010669 Verru_Chthon cassette protein C; Region: TIGR02599 1173025010670 Protein of unknown function (DUF3494); Region: DUF3494; pfam11999 1173025010671 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1173025010672 heat shock protein 90; Provisional; Region: PRK05218 1173025010673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025010674 ATP binding site [chemical binding]; other site 1173025010675 Mg2+ binding site [ion binding]; other site 1173025010676 G-X-G motif; other site 1173025010677 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1173025010678 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1173025010679 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1173025010680 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173025010681 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173025010682 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173025010683 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173025010684 active site 1173025010685 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173025010686 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173025010687 active site 1173025010688 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173025010689 CP12 domain; Region: CP12; cl14670 1173025010690 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1173025010691 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173025010692 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1173025010693 Probable transposase; Region: OrfB_IS605; pfam01385 1173025010694 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173025010695 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1173025010696 Domain of unknown function DUF21; Region: DUF21; pfam01595 1173025010697 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1173025010698 Transporter associated domain; Region: CorC_HlyC; smart01091 1173025010699 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1173025010700 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1173025010701 TRAM domain; Region: TRAM; cl01282 1173025010702 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1173025010703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173025010704 S-adenosylmethionine binding site [chemical binding]; other site 1173025010705 Phycobilisome protein; Region: Phycobilisome; cl08227 1173025010706 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 1173025010707 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1173025010708 Active_site [active] 1173025010709 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 1173025010710 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1173025010711 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1173025010712 Conserved TM helix; Region: TM_helix; pfam05552 1173025010713 Conserved TM helix; Region: TM_helix; pfam05552 1173025010714 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1173025010715 hydrophobic ligand binding site; other site 1173025010716 Uncharacterized conserved protein [Function unknown]; Region: COG2912 1173025010717 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1173025010718 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173025010719 binding surface 1173025010720 TPR motif; other site 1173025010721 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173025010722 ligand binding site [chemical binding]; other site 1173025010723 flexible hinge region; other site 1173025010724 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1173025010725 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1173025010726 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025010727 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025010728 dimer interface [polypeptide binding]; other site 1173025010729 phosphorylation site [posttranslational modification] 1173025010730 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069 1173025010731 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025010732 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025010733 dimer interface [polypeptide binding]; other site 1173025010734 phosphorylation site [posttranslational modification] 1173025010735 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025010736 ATP binding site [chemical binding]; other site 1173025010737 Mg2+ binding site [ion binding]; other site 1173025010738 G-X-G motif; other site 1173025010739 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1173025010740 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1173025010741 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1173025010742 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1173025010743 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1173025010744 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1173025010745 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173025010746 active site 1173025010747 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1173025010748 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1173025010749 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173025010750 Predicted membrane protein [Function unknown]; Region: COG2259 1173025010751 Rhomboid family; Region: Rhomboid; pfam01694 1173025010752 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173025010753 Bacterial SH3 domain; Region: SH3_3; pfam08239 1173025010754 Bacterial SH3 domain; Region: SH3_3; pfam08239 1173025010755 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1173025010756 Protein of unknown function (DUF2927); Region: DUF2927; pfam11150 1173025010757 Protein of unknown function (DUF3747); Region: DUF3747; pfam12565 1173025010758 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1173025010759 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1173025010760 active site 1173025010761 metal binding site [ion binding]; metal-binding site 1173025010762 Bacterial SH3 domain; Region: SH3_3; cl17532 1173025010763 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 1173025010764 GTP/Mg2+ binding site [chemical binding]; other site 1173025010765 G5 box; other site 1173025010766 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 1173025010767 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 1173025010768 G1 box; other site 1173025010769 G1 box; other site 1173025010770 GTP/Mg2+ binding site [chemical binding]; other site 1173025010771 Switch I region; other site 1173025010772 G2 box; other site 1173025010773 Switch II region; other site 1173025010774 G3 box; other site 1173025010775 G4 box; other site 1173025010776 G5 box; other site 1173025010777 Domain of unknown function (DUF697); Region: DUF697; pfam05128 1173025010778 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1173025010779 ribosomal protein S16; Region: rps16; CHL00005 1173025010780 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1173025010781 KH domain; Region: KH_4; pfam13083 1173025010782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173025010783 S-adenosylmethionine binding site [chemical binding]; other site 1173025010784 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1173025010785 RNA binding surface [nucleotide binding]; other site 1173025010786 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173025010787 Ligand Binding Site [chemical binding]; other site 1173025010788 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173025010789 Ligand Binding Site [chemical binding]; other site 1173025010790 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173025010791 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173025010792 active site 1173025010793 ATP binding site [chemical binding]; other site 1173025010794 substrate binding site [chemical binding]; other site 1173025010795 activation loop (A-loop); other site 1173025010796 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173025010797 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025010798 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173025010799 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025010800 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025010801 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025010802 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025010803 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1173025010804 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173025010805 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173025010806 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870 1173025010807 UbiA prenyltransferase family; Region: UbiA; pfam01040 1173025010808 Peptidase M35 family; Region: M35_like; cl03449 1173025010809 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1173025010810 ABC1 family; Region: ABC1; cl17513 1173025010811 ABC1 family; Region: ABC1; cl17513 1173025010812 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1173025010813 active site 1173025010814 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 1173025010815 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 1173025010816 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 1173025010817 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173025010818 dimer interface [polypeptide binding]; other site 1173025010819 putative metal binding site [ion binding]; other site 1173025010820 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1173025010821 active site 1173025010822 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025010823 GAF domain; Region: GAF_3; pfam13492 1173025010824 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173025010825 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173025010826 metal binding site [ion binding]; metal-binding site 1173025010827 active site 1173025010828 I-site; other site 1173025010829 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1173025010830 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025010831 binding surface 1173025010832 TPR motif; other site 1173025010833 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025010834 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025010835 binding surface 1173025010836 TPR motif; other site 1173025010837 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025010838 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1173025010839 active site 1173025010840 dimer interfaces [polypeptide binding]; other site 1173025010841 catalytic residues [active] 1173025010842 putative lipid kinase; Reviewed; Region: PRK00861 1173025010843 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1173025010844 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 1173025010845 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 1173025010846 NAD(P) binding site [chemical binding]; other site 1173025010847 catalytic residues [active] 1173025010848 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 1173025010849 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 1173025010850 polyphosphate kinase; Provisional; Region: PRK05443 1173025010851 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1173025010852 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1173025010853 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1173025010854 putative domain interface [polypeptide binding]; other site 1173025010855 putative active site [active] 1173025010856 catalytic site [active] 1173025010857 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1173025010858 putative domain interface [polypeptide binding]; other site 1173025010859 putative active site [active] 1173025010860 catalytic site [active] 1173025010861 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 1173025010862 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 1173025010863 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1173025010864 sulfite reductase subunit beta; Provisional; Region: PRK13504 1173025010865 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1173025010866 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1173025010867 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 1173025010868 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173025010869 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1173025010870 Lipase (class 2); Region: Lipase_2; pfam01674 1173025010871 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173025010872 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1173025010873 active site 1173025010874 metal binding site [ion binding]; metal-binding site 1173025010875 Integral membrane protein DUF92; Region: DUF92; pfam01940 1173025010876 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1173025010877 Ycf39; Provisional; Region: ycf39; CHL00194 1173025010878 NAD(P) binding site [chemical binding]; other site 1173025010879 putative active site [active] 1173025010880 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1173025010881 putative catalytic site [active] 1173025010882 putative phosphate binding site [ion binding]; other site 1173025010883 active site 1173025010884 metal binding site A [ion binding]; metal-binding site 1173025010885 DNA binding site [nucleotide binding] 1173025010886 putative AP binding site [nucleotide binding]; other site 1173025010887 putative metal binding site B [ion binding]; other site 1173025010888 Domain of unknown function DUF39; Region: DUF39; pfam01837 1173025010889 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025010890 binding surface 1173025010891 TPR motif; other site 1173025010892 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173025010893 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025010894 binding surface 1173025010895 TPR motif; other site 1173025010896 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025010897 Predicted membrane protein [Function unknown]; Region: COG2119 1173025010898 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1173025010899 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1173025010900 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1173025010901 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173025010902 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173025010903 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945 1173025010904 L-aspartate oxidase; Provisional; Region: PRK06175 1173025010905 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1173025010906 PAS domain S-box; Region: sensory_box; TIGR00229 1173025010907 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025010908 putative active site [active] 1173025010909 heme pocket [chemical binding]; other site 1173025010910 PAS domain S-box; Region: sensory_box; TIGR00229 1173025010911 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025010912 putative active site [active] 1173025010913 heme pocket [chemical binding]; other site 1173025010914 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025010915 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025010916 dimer interface [polypeptide binding]; other site 1173025010917 phosphorylation site [posttranslational modification] 1173025010918 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025010919 ATP binding site [chemical binding]; other site 1173025010920 Mg2+ binding site [ion binding]; other site 1173025010921 G-X-G motif; other site 1173025010922 S-layer homology domain; Region: SLH; pfam00395 1173025010923 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1173025010924 Predicted transcriptional regulator [Transcription]; Region: COG1959 1173025010925 Transcriptional regulator; Region: Rrf2; pfam02082 1173025010926 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1173025010927 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1173025010928 dimer interface [polypeptide binding]; other site 1173025010929 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173025010930 catalytic residue [active] 1173025010931 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 1173025010932 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173025010933 HSP70 interaction site [polypeptide binding]; other site 1173025010934 malate dehydrogenase; Reviewed; Region: PRK06223 1173025010935 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1173025010936 NAD(P) binding site [chemical binding]; other site 1173025010937 dimer interface [polypeptide binding]; other site 1173025010938 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1173025010939 substrate binding site [chemical binding]; other site 1173025010940 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 1173025010941 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 1173025010942 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1173025010943 DNA binding site [nucleotide binding] 1173025010944 catalytic residue [active] 1173025010945 H2TH interface [polypeptide binding]; other site 1173025010946 putative catalytic residues [active] 1173025010947 turnover-facilitating residue; other site 1173025010948 intercalation triad [nucleotide binding]; other site 1173025010949 8OG recognition residue [nucleotide binding]; other site 1173025010950 putative reading head residues; other site 1173025010951 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1173025010952 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1173025010953 photosystem I subunit IV; Reviewed; Region: psaE; CHL00125 1173025010954 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1173025010955 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1173025010956 substrate binding pocket [chemical binding]; other site 1173025010957 membrane-bound complex binding site; other site 1173025010958 hinge residues; other site 1173025010959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1173025010960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173025010961 dimer interface [polypeptide binding]; other site 1173025010962 ABC-ATPase subunit interface; other site 1173025010963 putative PBP binding loops; other site 1173025010964 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1173025010965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173025010966 dimer interface [polypeptide binding]; other site 1173025010967 conserved gate region; other site 1173025010968 putative PBP binding loops; other site 1173025010969 ABC-ATPase subunit interface; other site 1173025010970 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1173025010971 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1173025010972 Walker A/P-loop; other site 1173025010973 ATP binding site [chemical binding]; other site 1173025010974 Q-loop/lid; other site 1173025010975 ABC transporter signature motif; other site 1173025010976 Walker B; other site 1173025010977 D-loop; other site 1173025010978 H-loop/switch region; other site 1173025010979 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1173025010980 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1173025010981 catalytic motif [active] 1173025010982 Zn binding site [ion binding]; other site 1173025010983 RibD C-terminal domain; Region: RibD_C; cl17279 1173025010984 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1173025010985 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1173025010986 RNA polymerase sigma factor SigC; Validated; Region: PRK07598 1173025010987 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1173025010988 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173025010989 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1173025010990 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173025010991 DNA binding residues [nucleotide binding] 1173025010992 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1173025010993 metal binding site 2 [ion binding]; metal-binding site 1173025010994 putative DNA binding helix; other site 1173025010995 metal binding site 1 [ion binding]; metal-binding site 1173025010996 dimer interface [polypeptide binding]; other site 1173025010997 structural Zn2+ binding site [ion binding]; other site 1173025010998 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 1173025010999 Ycf46; Provisional; Region: ycf46; CHL00195 1173025011000 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173025011001 Walker A motif; other site 1173025011002 ATP binding site [chemical binding]; other site 1173025011003 Walker B motif; other site 1173025011004 arginine finger; other site 1173025011005 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1173025011006 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1173025011007 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1173025011008 G-X-X-G motif; other site 1173025011009 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1173025011010 RxxxH motif; other site 1173025011011 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 1173025011012 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1173025011013 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1173025011014 Bacterial PH domain; Region: DUF304; pfam03703 1173025011015 ribonuclease P; Reviewed; Region: rnpA; PRK03031 1173025011016 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1173025011017 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 1173025011018 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1173025011019 classical (c) SDRs; Region: SDR_c; cd05233 1173025011020 NAD(P) binding site [chemical binding]; other site 1173025011021 active site 1173025011022 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173025011023 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1173025011024 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1173025011025 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1173025011026 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1173025011027 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 1173025011028 ammonium transporter; Region: amt; TIGR00836 1173025011029 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 1173025011030 active site 1173025011031 catalytic triad [active] 1173025011032 oxyanion hole [active] 1173025011033 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371 1173025011034 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 1173025011035 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1173025011036 metal ion-dependent adhesion site (MIDAS); other site 1173025011037 CHAT domain; Region: CHAT; cl17868 1173025011038 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173025011039 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173025011040 phosphopeptide binding site; other site 1173025011041 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1173025011042 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1173025011043 active site 1173025011044 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1173025011045 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1173025011046 active site 1173025011047 catalytic site [active] 1173025011048 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025011049 TPR repeat; Region: TPR_11; pfam13414 1173025011050 binding surface 1173025011051 TPR motif; other site 1173025011052 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025011053 binding surface 1173025011054 TPR motif; other site 1173025011055 TPR repeat; Region: TPR_11; pfam13414 1173025011056 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 1173025011057 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1173025011058 HAS barrel domain; Region: HAS-barrel; pfam09378 1173025011059 HerA helicase [Replication, recombination, and repair]; Region: COG0433 1173025011060 Domain of unknown function DUF87; Region: DUF87; pfam01935 1173025011061 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025011062 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025011063 GAF domain; Region: GAF; pfam01590 1173025011064 GAF domain; Region: GAF_2; pfam13185 1173025011065 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025011066 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025011067 dimer interface [polypeptide binding]; other site 1173025011068 phosphorylation site [posttranslational modification] 1173025011069 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025011070 ATP binding site [chemical binding]; other site 1173025011071 Mg2+ binding site [ion binding]; other site 1173025011072 G-X-G motif; other site 1173025011073 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_11; cd08866 1173025011074 putative hydrophobic ligand binding site [chemical binding]; other site 1173025011075 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1173025011076 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1173025011077 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1173025011078 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1173025011079 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1173025011080 ligand binding site [chemical binding]; other site 1173025011081 homodimer interface [polypeptide binding]; other site 1173025011082 NAD(P) binding site [chemical binding]; other site 1173025011083 trimer interface B [polypeptide binding]; other site 1173025011084 trimer interface A [polypeptide binding]; other site 1173025011085 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1173025011086 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1173025011087 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173025011088 catalytic residue [active] 1173025011089 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1173025011090 catalytic center binding site [active] 1173025011091 ATP binding site [chemical binding]; other site 1173025011092 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1173025011093 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1173025011094 dimer interface [polypeptide binding]; other site 1173025011095 ADP-ribose binding site [chemical binding]; other site 1173025011096 active site 1173025011097 nudix motif; other site 1173025011098 metal binding site [ion binding]; metal-binding site 1173025011099 deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556 1173025011100 DNA photolyase; Region: DNA_photolyase; pfam00875 1173025011101 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1173025011102 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1173025011103 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1173025011104 hinge region; other site 1173025011105 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1173025011106 putative nucleotide binding site [chemical binding]; other site 1173025011107 uridine monophosphate binding site [chemical binding]; other site 1173025011108 homohexameric interface [polypeptide binding]; other site 1173025011109 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 1173025011110 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1173025011111 putative catalytic residue [active] 1173025011112 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1173025011113 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 1173025011114 catalytic triad [active] 1173025011115 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 1173025011116 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173025011117 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1173025011118 selenophosphate synthetase; Provisional; Region: PRK00943 1173025011119 dimerization interface [polypeptide binding]; other site 1173025011120 putative ATP binding site [chemical binding]; other site 1173025011121 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 1173025011122 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 1173025011123 active site residue [active] 1173025011124 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 1173025011125 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1173025011126 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 1173025011127 trimer interface [polypeptide binding]; other site 1173025011128 putative Zn binding site [ion binding]; other site 1173025011129 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 1173025011130 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1173025011131 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1173025011132 N-terminal domain interface [polypeptide binding]; other site 1173025011133 dimer interface [polypeptide binding]; other site 1173025011134 substrate binding pocket (H-site) [chemical binding]; other site 1173025011135 S-formylglutathione hydrolase; Region: PLN02442 1173025011136 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1173025011137 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1173025011138 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173025011139 P-loop; other site 1173025011140 Magnesium ion binding site [ion binding]; other site 1173025011141 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173025011142 Magnesium ion binding site [ion binding]; other site 1173025011143 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1173025011144 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1173025011145 substrate binding site [chemical binding]; other site 1173025011146 catalytic Zn binding site [ion binding]; other site 1173025011147 NAD binding site [chemical binding]; other site 1173025011148 structural Zn binding site [ion binding]; other site 1173025011149 dimer interface [polypeptide binding]; other site 1173025011150 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1173025011151 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025011152 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025011153 binding surface 1173025011154 TPR motif; other site 1173025011155 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025011156 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 1173025011157 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 1173025011158 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1173025011159 E-class dimer interface [polypeptide binding]; other site 1173025011160 P-class dimer interface [polypeptide binding]; other site 1173025011161 active site 1173025011162 Cu2+ binding site [ion binding]; other site 1173025011163 Zn2+ binding site [ion binding]; other site 1173025011164 GTP-binding protein YchF; Reviewed; Region: PRK09601 1173025011165 YchF GTPase; Region: YchF; cd01900 1173025011166 G1 box; other site 1173025011167 GTP/Mg2+ binding site [chemical binding]; other site 1173025011168 Switch I region; other site 1173025011169 G2 box; other site 1173025011170 Switch II region; other site 1173025011171 G3 box; other site 1173025011172 G4 box; other site 1173025011173 G5 box; other site 1173025011174 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1173025011175 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 1173025011176 putative active site [active] 1173025011177 Mn binding site [ion binding]; other site 1173025011178 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 1173025011179 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1173025011180 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173025011181 ATP binding site [chemical binding]; other site 1173025011182 putative Mg++ binding site [ion binding]; other site 1173025011183 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1173025011184 nucleotide binding region [chemical binding]; other site 1173025011185 ATP-binding site [chemical binding]; other site 1173025011186 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1173025011187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1173025011188 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1173025011189 FlxA-like protein; Region: FlxA; pfam14282 1173025011190 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1173025011191 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1173025011192 Fic family protein [Function unknown]; Region: COG3177 1173025011193 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 1173025011194 Fic/DOC family; Region: Fic; pfam02661 1173025011195 Protein of unknown function (DUF433); Region: DUF433; cl01030 1173025011196 hypothetical protein; Validated; Region: PRK07078 1173025011197 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1173025011198 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1173025011199 active site 1173025011200 catalytic residues [active] 1173025011201 DNA binding site [nucleotide binding] 1173025011202 Int/Topo IB signature motif; other site 1173025011203 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1173025011204 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1173025011205 sulfate transport protein; Provisional; Region: cysT; CHL00187 1173025011206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173025011207 dimer interface [polypeptide binding]; other site 1173025011208 conserved gate region; other site 1173025011209 putative PBP binding loops; other site 1173025011210 ABC-ATPase subunit interface; other site 1173025011211 sulfate transport protein; Provisional; Region: cysT; CHL00187 1173025011212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173025011213 dimer interface [polypeptide binding]; other site 1173025011214 conserved gate region; other site 1173025011215 putative PBP binding loops; other site 1173025011216 ABC-ATPase subunit interface; other site 1173025011217 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173025011218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025011219 active site 1173025011220 phosphorylation site [posttranslational modification] 1173025011221 intermolecular recognition site; other site 1173025011222 dimerization interface [polypeptide binding]; other site 1173025011223 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173025011224 DNA binding residues [nucleotide binding] 1173025011225 dimerization interface [polypeptide binding]; other site 1173025011226 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1173025011227 dimer interface [polypeptide binding]; other site 1173025011228 [2Fe-2S] cluster binding site [ion binding]; other site 1173025011229 Septum formation topological specificity factor MinE; Region: MinE; cl00538 1173025011230 septum site-determining protein MinD; Region: minD_bact; TIGR01968 1173025011231 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1173025011232 Switch I; other site 1173025011233 Switch II; other site 1173025011234 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1173025011235 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1173025011236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1173025011237 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173025011238 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173025011239 phosphopeptide binding site; other site 1173025011240 Double zinc ribbon; Region: DZR; pfam12773 1173025011241 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1173025011242 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1173025011243 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173025011244 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173025011245 phosphopeptide binding site; other site 1173025011246 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1173025011247 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1173025011248 putative active site [active] 1173025011249 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 1173025011250 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 1173025011251 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 1173025011252 Probable Catalytic site; other site 1173025011253 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 1173025011254 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1173025011255 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173025011256 putative metal binding site; other site 1173025011257 Uncharacterized conserved protein [Function unknown]; Region: COG2928 1173025011258 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1173025011259 putative RNA binding site [nucleotide binding]; other site 1173025011260 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1173025011261 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1173025011262 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1173025011263 P loop; other site 1173025011264 GTP binding site [chemical binding]; other site 1173025011265 GAF domain; Region: GAF_3; pfam13492 1173025011266 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1173025011267 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1173025011268 argininosuccinate lyase; Provisional; Region: PRK00855 1173025011269 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1173025011270 active sites [active] 1173025011271 tetramer interface [polypeptide binding]; other site 1173025011272 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025011273 binding surface 1173025011274 TPR motif; other site 1173025011275 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1173025011276 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025011277 binding surface 1173025011278 TPR motif; other site 1173025011279 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1173025011280 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025011281 binding surface 1173025011282 TPR motif; other site 1173025011283 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025011284 binding surface 1173025011285 TPR motif; other site 1173025011286 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025011287 binding surface 1173025011288 TPR motif; other site 1173025011289 CpeS-like protein; Region: CpeS; pfam09367 1173025011290 Protein of unknown function (DUF3747); Region: DUF3747; pfam12565 1173025011291 S-layer homology domain; Region: SLH; pfam00395 1173025011292 S-layer homology domain; Region: SLH; pfam00395 1173025011293 Phosphoglycerate kinase; Region: PGK; pfam00162 1173025011294 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1173025011295 substrate binding site [chemical binding]; other site 1173025011296 hinge regions; other site 1173025011297 ADP binding site [chemical binding]; other site 1173025011298 catalytic site [active] 1173025011299 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173025011300 Ligand Binding Site [chemical binding]; other site 1173025011301 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1173025011302 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1173025011303 GTP/Mg2+ binding site [chemical binding]; other site 1173025011304 G4 box; other site 1173025011305 G5 box; other site 1173025011306 G1 box; other site 1173025011307 Switch I region; other site 1173025011308 G2 box; other site 1173025011309 G3 box; other site 1173025011310 Switch II region; other site 1173025011311 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173025011312 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173025011313 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173025011314 HEAT repeats; Region: HEAT_2; pfam13646 1173025011315 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 1173025011316 PBS lyase HEAT-like repeat; Region: HEAT_PBS; pfam03130 1173025011317 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 1173025011318 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 1173025011319 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173025011320 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 1173025011321 phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338 1173025011322 phycocyanin beta subunit; Reviewed; Region: cpcB; CHL00171 1173025011323 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1173025011324 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1173025011325 RNA binding surface [nucleotide binding]; other site 1173025011326 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1173025011327 active site 1173025011328 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1173025011329 active site 1173025011330 SAM binding site [chemical binding]; other site 1173025011331 homodimer interface [polypeptide binding]; other site 1173025011332 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1173025011333 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1173025011334 putative active site [active] 1173025011335 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1173025011336 putative active site [active] 1173025011337 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173025011338 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173025011339 active site 1173025011340 ATP binding site [chemical binding]; other site 1173025011341 substrate binding site [chemical binding]; other site 1173025011342 activation loop (A-loop); other site 1173025011343 GUN4-like; Region: GUN4; pfam05419 1173025011344 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 1173025011345 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1173025011346 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173025011347 Walker A/P-loop; other site 1173025011348 ATP binding site [chemical binding]; other site 1173025011349 Q-loop/lid; other site 1173025011350 ABC transporter signature motif; other site 1173025011351 Walker B; other site 1173025011352 D-loop; other site 1173025011353 H-loop/switch region; other site 1173025011354 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1173025011355 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1173025011356 Protein of unknown function (DUF760); Region: DUF760; pfam05542 1173025011357 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1173025011358 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173025011359 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1173025011360 protein binding site [polypeptide binding]; other site 1173025011361 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173025011362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025011363 active site 1173025011364 phosphorylation site [posttranslational modification] 1173025011365 intermolecular recognition site; other site 1173025011366 dimerization interface [polypeptide binding]; other site 1173025011367 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173025011368 DNA binding site [nucleotide binding] 1173025011369 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 1173025011370 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1173025011371 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1173025011372 active site 1173025011373 metal binding site [ion binding]; metal-binding site 1173025011374 DNA binding site [nucleotide binding] 1173025011375 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025011376 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173025011377 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025011378 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025011379 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025011380 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173025011381 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025011382 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025011383 TPR repeat; Region: TPR_11; pfam13414 1173025011384 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025011385 TPR motif; other site 1173025011386 binding surface 1173025011387 TPR repeat; Region: TPR_11; pfam13414 1173025011388 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025011389 binding surface 1173025011390 TPR motif; other site 1173025011391 TPR repeat; Region: TPR_11; pfam13414 1173025011392 TPR repeat; Region: TPR_11; pfam13414 1173025011393 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025011394 binding surface 1173025011395 TPR motif; other site 1173025011396 TPR repeat; Region: TPR_11; pfam13414 1173025011397 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1173025011398 heterotetramer interface [polypeptide binding]; other site 1173025011399 active site pocket [active] 1173025011400 cleavage site 1173025011401 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1173025011402 Aspartase; Region: Aspartase; cd01357 1173025011403 active sites [active] 1173025011404 tetramer interface [polypeptide binding]; other site 1173025011405 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173025011406 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1173025011407 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1173025011408 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1173025011409 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1173025011410 putative active site [active] 1173025011411 oxyanion strand; other site 1173025011412 catalytic triad [active] 1173025011413 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1173025011414 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173025011415 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 1173025011416 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 1173025011417 threonine synthase; Reviewed; Region: PRK06721 1173025011418 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1173025011419 homodimer interface [polypeptide binding]; other site 1173025011420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173025011421 catalytic residue [active] 1173025011422 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 1173025011423 Peptidase family M50; Region: Peptidase_M50; pfam02163 1173025011424 active site 1173025011425 putative substrate binding region [chemical binding]; other site 1173025011426 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1173025011427 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025011428 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025011429 PAS fold; Region: PAS_4; pfam08448 1173025011430 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025011431 dimer interface [polypeptide binding]; other site 1173025011432 phosphorylation site [posttranslational modification] 1173025011433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025011434 ATP binding site [chemical binding]; other site 1173025011435 Mg2+ binding site [ion binding]; other site 1173025011436 G-X-G motif; other site 1173025011437 carboxyl-terminal processing protease; Provisional; Region: PLN00049 1173025011438 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1173025011439 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1173025011440 protein binding site [polypeptide binding]; other site 1173025011441 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1173025011442 Catalytic dyad [active] 1173025011443 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1173025011444 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1173025011445 Qi binding site; other site 1173025011446 intrachain domain interface; other site 1173025011447 interchain domain interface [polypeptide binding]; other site 1173025011448 heme bH binding site [chemical binding]; other site 1173025011449 heme bL binding site [chemical binding]; other site 1173025011450 Qo binding site; other site 1173025011451 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 1173025011452 interchain domain interface [polypeptide binding]; other site 1173025011453 intrachain domain interface; other site 1173025011454 Qi binding site; other site 1173025011455 Qo binding site; other site 1173025011456 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1173025011457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025011458 ATP binding site [chemical binding]; other site 1173025011459 Mg2+ binding site [ion binding]; other site 1173025011460 G-X-G motif; other site 1173025011461 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1173025011462 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1173025011463 NADP-binding site; other site 1173025011464 homotetramer interface [polypeptide binding]; other site 1173025011465 substrate binding site [chemical binding]; other site 1173025011466 homodimer interface [polypeptide binding]; other site 1173025011467 active site 1173025011468 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173025011469 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173025011470 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1173025011471 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1173025011472 Catalytic site [active] 1173025011473 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1173025011474 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 1173025011475 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1173025011476 RNA binding site [nucleotide binding]; other site 1173025011477 active site 1173025011478 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1173025011479 Helix-turn-helix domain; Region: HTH_25; pfam13413 1173025011480 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1173025011481 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1173025011482 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1173025011483 Surface antigen; Region: Bac_surface_Ag; pfam01103 1173025011484 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173025011485 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173025011486 active site 1173025011487 ATP binding site [chemical binding]; other site 1173025011488 substrate binding site [chemical binding]; other site 1173025011489 activation loop (A-loop); other site 1173025011490 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025011491 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025011492 active site 1173025011493 phosphorylation site [posttranslational modification] 1173025011494 intermolecular recognition site; other site 1173025011495 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025011496 dimerization interface [polypeptide binding]; other site 1173025011497 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025011498 dimer interface [polypeptide binding]; other site 1173025011499 phosphorylation site [posttranslational modification] 1173025011500 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025011501 ATP binding site [chemical binding]; other site 1173025011502 Mg2+ binding site [ion binding]; other site 1173025011503 G-X-G motif; other site 1173025011504 CHASE3 domain; Region: CHASE3; pfam05227 1173025011505 PAS domain S-box; Region: sensory_box; TIGR00229 1173025011506 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025011507 putative active site [active] 1173025011508 heme pocket [chemical binding]; other site 1173025011509 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173025011510 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025011511 putative active site [active] 1173025011512 heme pocket [chemical binding]; other site 1173025011513 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025011514 dimer interface [polypeptide binding]; other site 1173025011515 phosphorylation site [posttranslational modification] 1173025011516 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025011517 ATP binding site [chemical binding]; other site 1173025011518 Mg2+ binding site [ion binding]; other site 1173025011519 G-X-G motif; other site 1173025011520 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025011521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025011522 active site 1173025011523 phosphorylation site [posttranslational modification] 1173025011524 intermolecular recognition site; other site 1173025011525 dimerization interface [polypeptide binding]; other site 1173025011526 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025011527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025011528 active site 1173025011529 phosphorylation site [posttranslational modification] 1173025011530 intermolecular recognition site; other site 1173025011531 dimerization interface [polypeptide binding]; other site 1173025011532 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173025011533 putative binding surface; other site 1173025011534 active site 1173025011535 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1173025011536 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1173025011537 dimer interface [polypeptide binding]; other site 1173025011538 putative functional site; other site 1173025011539 putative MPT binding site; other site 1173025011540 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1173025011541 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025011542 TPR motif; other site 1173025011543 TPR repeat; Region: TPR_11; pfam13414 1173025011544 binding surface 1173025011545 Proline dehydrogenase; Region: Pro_dh; pfam01619 1173025011546 delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Region: D1pyr5carbox2; TIGR01237 1173025011547 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1173025011548 Glutamate binding site [chemical binding]; other site 1173025011549 homodimer interface [polypeptide binding]; other site 1173025011550 NAD binding site [chemical binding]; other site 1173025011551 catalytic residues [active] 1173025011552 Predicted membrane protein [Function unknown]; Region: COG3463 1173025011553 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 1173025011554 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173025011555 Ligand Binding Site [chemical binding]; other site 1173025011556 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173025011557 Ligand Binding Site [chemical binding]; other site 1173025011558 adaptive-response sensory kinase; Validated; Region: PRK09303 1173025011559 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 1173025011560 tetramer interface [polypeptide binding]; other site 1173025011561 dimer interface [polypeptide binding]; other site 1173025011562 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025011563 dimer interface [polypeptide binding]; other site 1173025011564 phosphorylation site [posttranslational modification] 1173025011565 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025011566 ATP binding site [chemical binding]; other site 1173025011567 Mg2+ binding site [ion binding]; other site 1173025011568 G-X-G motif; other site 1173025011569 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173025011570 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173025011571 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173025011572 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173025011573 ligand binding site [chemical binding]; other site 1173025011574 flexible hinge region; other site 1173025011575 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1173025011576 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173025011577 Walker A motif; other site 1173025011578 ATP binding site [chemical binding]; other site 1173025011579 Walker B motif; other site 1173025011580 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 1173025011581 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1173025011582 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1173025011583 PAS fold; Region: PAS_4; pfam08448 1173025011584 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1173025011585 cyclase homology domain; Region: CHD; cd07302 1173025011586 nucleotidyl binding site; other site 1173025011587 metal binding site [ion binding]; metal-binding site 1173025011588 dimer interface [polypeptide binding]; other site 1173025011589 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1173025011590 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1173025011591 domain interfaces; other site 1173025011592 active site 1173025011593 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1173025011594 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1173025011595 ABC transporter; Region: ABC_tran_2; pfam12848 1173025011596 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1173025011597 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173025011598 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1173025011599 Probable transposase; Region: OrfB_IS605; pfam01385 1173025011600 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173025011601 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 1173025011602 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173025011603 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173025011604 active site 1173025011605 ATP binding site [chemical binding]; other site 1173025011606 substrate binding site [chemical binding]; other site 1173025011607 activation loop (A-loop); other site 1173025011608 ribosomal protein L33; Region: rpl33; CHL00104 1173025011609 ribosomal protein S18; Region: rps18; CHL00077 1173025011610 Exoribonuclease R [Transcription]; Region: VacB; COG0557 1173025011611 RNB domain; Region: RNB; pfam00773 1173025011612 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173025011613 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173025011614 phosphopeptide binding site; other site 1173025011615 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1173025011616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1173025011617 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1173025011618 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1173025011619 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1173025011620 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1173025011621 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 1173025011622 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 1173025011623 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 1173025011624 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1173025011625 catalytic core [active] 1173025011626 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173025011627 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173025011628 S-adenosylmethionine binding site [chemical binding]; other site 1173025011629 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025011630 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025011631 binding surface 1173025011632 TPR motif; other site 1173025011633 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173025011634 RDD family; Region: RDD; pfam06271 1173025011635 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173025011636 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025011637 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173025011638 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025011639 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025011640 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 1173025011641 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1173025011642 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1173025011643 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1173025011644 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cd04434 1173025011645 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1173025011646 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1173025011647 active site 1173025011648 zinc binding site [ion binding]; other site 1173025011649 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173025011650 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025011651 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025011652 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 1173025011653 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173025011654 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 1173025011655 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173025011656 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1173025011657 active site 1173025011658 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1173025011659 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1173025011660 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1173025011661 putative active site [active] 1173025011662 putative substrate binding site [chemical binding]; other site 1173025011663 putative cosubstrate binding site; other site 1173025011664 catalytic site [active] 1173025011665 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 1173025011666 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1173025011667 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 1173025011668 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1173025011669 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173025011670 Walker A/P-loop; other site 1173025011671 ATP binding site [chemical binding]; other site 1173025011672 Q-loop/lid; other site 1173025011673 ABC transporter signature motif; other site 1173025011674 Walker B; other site 1173025011675 D-loop; other site 1173025011676 H-loop/switch region; other site 1173025011677 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1173025011678 MoxR-like ATPases [General function prediction only]; Region: COG0714 1173025011679 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173025011680 Walker A motif; other site 1173025011681 ATP binding site [chemical binding]; other site 1173025011682 Walker B motif; other site 1173025011683 arginine finger; other site 1173025011684 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1173025011685 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1173025011686 Riboflavin kinase; Region: Flavokinase; smart00904 1173025011687 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1173025011688 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1173025011689 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1173025011690 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1173025011691 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1173025011692 dimer interface [polypeptide binding]; other site 1173025011693 motif 1; other site 1173025011694 active site 1173025011695 motif 2; other site 1173025011696 motif 3; other site 1173025011697 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025011698 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025011699 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025011700 PAS fold; Region: PAS_3; pfam08447 1173025011701 putative active site [active] 1173025011702 heme pocket [chemical binding]; other site 1173025011703 PAS domain S-box; Region: sensory_box; TIGR00229 1173025011704 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025011705 putative active site [active] 1173025011706 heme pocket [chemical binding]; other site 1173025011707 PAS fold; Region: PAS_4; pfam08448 1173025011708 PAS domain S-box; Region: sensory_box; TIGR00229 1173025011709 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025011710 putative active site [active] 1173025011711 heme pocket [chemical binding]; other site 1173025011712 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025011713 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025011714 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173025011715 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173025011716 metal binding site [ion binding]; metal-binding site 1173025011717 active site 1173025011718 I-site; other site 1173025011719 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1173025011720 enolase; Provisional; Region: eno; PRK00077 1173025011721 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1173025011722 dimer interface [polypeptide binding]; other site 1173025011723 metal binding site [ion binding]; metal-binding site 1173025011724 substrate binding pocket [chemical binding]; other site 1173025011725 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173025011726 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1173025011727 dimer interface [polypeptide binding]; other site 1173025011728 active site 1173025011729 metal binding site [ion binding]; metal-binding site 1173025011730 glutathione binding site [chemical binding]; other site 1173025011731 S-layer homology domain; Region: SLH; pfam00395 1173025011732 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 1173025011733 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1173025011734 Clp amino terminal domain; Region: Clp_N; pfam02861 1173025011735 Clp amino terminal domain; Region: Clp_N; pfam02861 1173025011736 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173025011737 Walker A motif; other site 1173025011738 ATP binding site [chemical binding]; other site 1173025011739 Walker B motif; other site 1173025011740 arginine finger; other site 1173025011741 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173025011742 Walker A motif; other site 1173025011743 ATP binding site [chemical binding]; other site 1173025011744 Walker B motif; other site 1173025011745 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1173025011746 Protein of unknown function (DUF1012); Region: DUF1012; pfam06241 1173025011747 TrkA-N domain; Region: TrkA_N; pfam02254 1173025011748 Protein of unknown function (DUF1517); Region: DUF1517; pfam07466 1173025011749 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1173025011750 thiS-thiF/thiG interaction site; other site 1173025011751 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 1173025011752 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1173025011753 thiamine phosphate binding site [chemical binding]; other site 1173025011754 active site 1173025011755 pyrophosphate binding site [ion binding]; other site 1173025011756 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 1173025011757 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 1173025011758 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 1173025011759 FIST N domain; Region: FIST; smart00897 1173025011760 FIST C domain; Region: FIST_C; pfam10442 1173025011761 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1173025011762 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173025011763 active site 1173025011764 metal binding site [ion binding]; metal-binding site 1173025011765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173025011766 S-adenosylmethionine binding site [chemical binding]; other site 1173025011767 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1173025011768 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173025011769 Ligand Binding Site [chemical binding]; other site 1173025011770 tryptophan-rich conserved hypothetical protein; Region: TIGR02450 1173025011771 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1173025011772 succinyldiaminopimelate transaminase; Validated; Region: PRK07366 1173025011773 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1173025011774 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173025011775 homodimer interface [polypeptide binding]; other site 1173025011776 catalytic residue [active] 1173025011777 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1173025011778 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1173025011779 catalytic residues [active] 1173025011780 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173025011781 S-adenosylmethionine binding site [chemical binding]; other site 1173025011782 EamA-like transporter family; Region: EamA; pfam00892 1173025011783 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173025011784 carotene isomerase; Region: carot_isom; TIGR02730 1173025011785 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1173025011786 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1173025011787 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1173025011788 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1173025011789 GatB domain; Region: GatB_Yqey; pfam02637 1173025011790 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1173025011791 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1173025011792 dimer interface [polypeptide binding]; other site 1173025011793 putative anticodon binding site; other site 1173025011794 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1173025011795 motif 1; other site 1173025011796 active site 1173025011797 motif 2; other site 1173025011798 motif 3; other site 1173025011799 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 1173025011800 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1173025011801 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1173025011802 active site 1173025011803 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173025011804 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173025011805 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1173025011806 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1173025011807 putative dimer interface [polypeptide binding]; other site 1173025011808 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173025011809 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173025011810 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 1173025011811 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1173025011812 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173025011813 DevC protein; Region: devC; TIGR01185 1173025011814 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1173025011815 FtsX-like permease family; Region: FtsX; pfam02687 1173025011816 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 1173025011817 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1173025011818 Walker A/P-loop; other site 1173025011819 ATP binding site [chemical binding]; other site 1173025011820 Q-loop/lid; other site 1173025011821 ABC transporter signature motif; other site 1173025011822 Walker B; other site 1173025011823 D-loop; other site 1173025011824 H-loop/switch region; other site 1173025011825 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1173025011826 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1173025011827 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1173025011828 Zn2+ binding site [ion binding]; other site 1173025011829 Mg2+ binding site [ion binding]; other site 1173025011830 gamma-glutamyl kinase; Provisional; Region: PRK05429 1173025011831 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1173025011832 nucleotide binding site [chemical binding]; other site 1173025011833 homotetrameric interface [polypeptide binding]; other site 1173025011834 putative phosphate binding site [ion binding]; other site 1173025011835 putative allosteric binding site; other site 1173025011836 PUA domain; Region: PUA; pfam01472 1173025011837 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1173025011838 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173025011839 YceG-like family; Region: YceG; pfam02618 1173025011840 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1173025011841 dimerization interface [polypeptide binding]; other site 1173025011842 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 1173025011843 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 1173025011844 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1173025011845 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1173025011846 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173025011847 Coenzyme A binding pocket [chemical binding]; other site 1173025011848 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 1173025011849 Predicted membrane protein [Function unknown]; Region: COG2324 1173025011850 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 1173025011851 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173025011852 active site 1173025011853 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1173025011854 ZIP Zinc transporter; Region: Zip; pfam02535 1173025011855 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025011856 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173025011857 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025011858 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025011859 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1173025011860 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1173025011861 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1173025011862 PsaD; Region: PsaD; pfam02531 1173025011863 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 1173025011864 GAF domain; Region: GAF; pfam01590 1173025011865 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025011866 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025011867 dimer interface [polypeptide binding]; other site 1173025011868 phosphorylation site [posttranslational modification] 1173025011869 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025011870 ATP binding site [chemical binding]; other site 1173025011871 Mg2+ binding site [ion binding]; other site 1173025011872 G-X-G motif; other site 1173025011873 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 1173025011874 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1173025011875 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173025011876 binding surface 1173025011877 TPR motif; other site 1173025011878 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173025011879 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173025011880 active site 1173025011881 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173025011882 active site 1173025011883 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1173025011884 Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899 1173025011885 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 1173025011886 BioY family; Region: BioY; pfam02632 1173025011887 biotin synthase; Region: bioB; TIGR00433 1173025011888 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173025011889 FeS/SAM binding site; other site 1173025011890 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1173025011891 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025011892 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173025011893 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025011894 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025011895 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173025011896 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025011897 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025011898 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1173025011899 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1173025011900 substrate binding site [chemical binding]; other site 1173025011901 dimer interface [polypeptide binding]; other site 1173025011902 ATP binding site [chemical binding]; other site 1173025011903 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1173025011904 active site 1173025011905 tetramer interface [polypeptide binding]; other site 1173025011906 Putative transcription activator [Transcription]; Region: TenA; COG0819 1173025011907 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1173025011908 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 1173025011909 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 1173025011910 putative catalytic residue [active] 1173025011911 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1173025011912 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1173025011913 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1173025011914 NAD(P) binding site [chemical binding]; other site 1173025011915 ferrochelatase; Reviewed; Region: hemH; PRK00035 1173025011916 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1173025011917 active site 1173025011918 C-terminal domain interface [polypeptide binding]; other site 1173025011919 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1173025011920 active site 1173025011921 N-terminal domain interface [polypeptide binding]; other site 1173025011922 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504 1173025011923 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1173025011924 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1173025011925 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1173025011926 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1173025011927 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1173025011928 anti sigma factor interaction site; other site 1173025011929 regulatory phosphorylation site [posttranslational modification]; other site 1173025011930 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025011931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025011932 active site 1173025011933 phosphorylation site [posttranslational modification] 1173025011934 intermolecular recognition site; other site 1173025011935 dimerization interface [polypeptide binding]; other site 1173025011936 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1173025011937 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1173025011938 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025011939 GAF domain; Region: GAF; pfam01590 1173025011940 PAS domain S-box; Region: sensory_box; TIGR00229 1173025011941 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025011942 putative active site [active] 1173025011943 heme pocket [chemical binding]; other site 1173025011944 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025011945 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025011946 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025011947 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025011948 dimer interface [polypeptide binding]; other site 1173025011949 phosphorylation site [posttranslational modification] 1173025011950 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025011951 ATP binding site [chemical binding]; other site 1173025011952 Mg2+ binding site [ion binding]; other site 1173025011953 G-X-G motif; other site 1173025011954 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173025011955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025011956 active site 1173025011957 phosphorylation site [posttranslational modification] 1173025011958 intermolecular recognition site; other site 1173025011959 dimerization interface [polypeptide binding]; other site 1173025011960 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173025011961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025011962 active site 1173025011963 phosphorylation site [posttranslational modification] 1173025011964 intermolecular recognition site; other site 1173025011965 dimerization interface [polypeptide binding]; other site 1173025011966 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173025011967 putative binding surface; other site 1173025011968 active site 1173025011969 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1173025011970 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1173025011971 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025011972 TPR repeat; Region: TPR_11; pfam13414 1173025011973 binding surface 1173025011974 TPR motif; other site 1173025011975 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1173025011976 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1173025011977 CHASE3 domain; Region: CHASE3; cl05000 1173025011978 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1173025011979 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1173025011980 dimer interface [polypeptide binding]; other site 1173025011981 putative CheW interface [polypeptide binding]; other site 1173025011982 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173025011983 putative binding surface; other site 1173025011984 active site 1173025011985 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1173025011986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025011987 ATP binding site [chemical binding]; other site 1173025011988 Mg2+ binding site [ion binding]; other site 1173025011989 G-X-G motif; other site 1173025011990 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1173025011991 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025011992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025011993 active site 1173025011994 phosphorylation site [posttranslational modification] 1173025011995 intermolecular recognition site; other site 1173025011996 dimerization interface [polypeptide binding]; other site 1173025011997 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1173025011998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025011999 active site 1173025012000 phosphorylation site [posttranslational modification] 1173025012001 intermolecular recognition site; other site 1173025012002 dimerization interface [polypeptide binding]; other site 1173025012003 CheB methylesterase; Region: CheB_methylest; pfam01339 1173025012004 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025012005 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025012006 active site 1173025012007 phosphorylation site [posttranslational modification] 1173025012008 intermolecular recognition site; other site 1173025012009 dimerization interface [polypeptide binding]; other site 1173025012010 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025012011 GAF domain; Region: GAF; pfam01590 1173025012012 PAS fold; Region: PAS_4; pfam08448 1173025012013 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025012014 putative active site [active] 1173025012015 heme pocket [chemical binding]; other site 1173025012016 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025012017 GAF domain; Region: GAF_3; pfam13492 1173025012018 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025012019 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025012020 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025012021 dimer interface [polypeptide binding]; other site 1173025012022 phosphorylation site [posttranslational modification] 1173025012023 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025012024 ATP binding site [chemical binding]; other site 1173025012025 Mg2+ binding site [ion binding]; other site 1173025012026 G-X-G motif; other site 1173025012027 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173025012028 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025012029 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025012030 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1173025012031 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 1173025012032 active site 1173025012033 Zn binding site [ion binding]; other site 1173025012034 tellurite resistance protein terB; Region: terB; cd07176 1173025012035 putative metal binding site [ion binding]; other site 1173025012036 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1173025012037 dimer interface [polypeptide binding]; other site 1173025012038 ADP-ribose binding site [chemical binding]; other site 1173025012039 active site 1173025012040 nudix motif; other site 1173025012041 metal binding site [ion binding]; metal-binding site 1173025012042 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 1173025012043 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1173025012044 Putative esterase; Region: Esterase; pfam00756 1173025012045 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1173025012046 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1173025012047 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1173025012048 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1173025012049 RNA binding site [nucleotide binding]; other site 1173025012050 aspartate aminotransferase; Provisional; Region: PRK05764 1173025012051 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1173025012052 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173025012053 homodimer interface [polypeptide binding]; other site 1173025012054 catalytic residue [active] 1173025012055 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1173025012056 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1173025012057 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173025012058 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1173025012059 Probable transposase; Region: OrfB_IS605; pfam01385 1173025012060 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173025012061 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1173025012062 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1173025012063 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1173025012064 active site residue [active] 1173025012065 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1173025012066 active site residue [active] 1173025012067 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1173025012068 Peptidase family M23; Region: Peptidase_M23; pfam01551 1173025012069 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173025012070 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173025012071 dimerization interface [polypeptide binding]; other site 1173025012072 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025012073 dimer interface [polypeptide binding]; other site 1173025012074 phosphorylation site [posttranslational modification] 1173025012075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025012076 ATP binding site [chemical binding]; other site 1173025012077 Mg2+ binding site [ion binding]; other site 1173025012078 G-X-G motif; other site 1173025012079 PAS domain S-box; Region: sensory_box; TIGR00229 1173025012080 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025012081 putative active site [active] 1173025012082 heme pocket [chemical binding]; other site 1173025012083 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173025012084 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173025012085 putative active site [active] 1173025012086 heme pocket [chemical binding]; other site 1173025012087 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025012088 dimer interface [polypeptide binding]; other site 1173025012089 phosphorylation site [posttranslational modification] 1173025012090 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025012091 ATP binding site [chemical binding]; other site 1173025012092 Mg2+ binding site [ion binding]; other site 1173025012093 G-X-G motif; other site 1173025012094 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025012095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025012096 active site 1173025012097 phosphorylation site [posttranslational modification] 1173025012098 intermolecular recognition site; other site 1173025012099 dimerization interface [polypeptide binding]; other site 1173025012100 Response regulator receiver domain; Region: Response_reg; pfam00072 1173025012101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025012102 active site 1173025012103 phosphorylation site [posttranslational modification] 1173025012104 intermolecular recognition site; other site 1173025012105 dimerization interface [polypeptide binding]; other site 1173025012106 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025012107 dimer interface [polypeptide binding]; other site 1173025012108 phosphorylation site [posttranslational modification] 1173025012109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025012110 ATP binding site [chemical binding]; other site 1173025012111 Mg2+ binding site [ion binding]; other site 1173025012112 G-X-G motif; other site 1173025012113 amidophosphoribosyltransferase; Provisional; Region: PRK07349 1173025012114 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1173025012115 active site 1173025012116 tetramer interface [polypeptide binding]; other site 1173025012117 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173025012118 active site 1173025012119 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1173025012120 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1173025012121 dimerization interface [polypeptide binding]; other site 1173025012122 ATP binding site [chemical binding]; other site 1173025012123 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1173025012124 dimerization interface [polypeptide binding]; other site 1173025012125 ATP binding site [chemical binding]; other site 1173025012126 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1173025012127 Fe-S cluster binding site [ion binding]; other site 1173025012128 active site 1173025012129 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1173025012130 active site 1173025012131 dimer interface [polypeptide binding]; other site 1173025012132 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1173025012133 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1173025012134 active site 1173025012135 HIGH motif; other site 1173025012136 dimer interface [polypeptide binding]; other site 1173025012137 KMSKS motif; other site 1173025012138 Transglycosylase; Region: Transgly; pfam00912 1173025012139 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1173025012140 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1173025012141 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 1173025012142 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1173025012143 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1173025012144 ATP binding site [chemical binding]; other site 1173025012145 Mg2+ binding site [ion binding]; other site 1173025012146 G-X-G motif; other site 1173025012147 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1173025012148 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1173025012149 putative dimer interface [polypeptide binding]; other site 1173025012150 putative anticodon binding site; other site 1173025012151 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1173025012152 homodimer interface [polypeptide binding]; other site 1173025012153 motif 1; other site 1173025012154 motif 2; other site 1173025012155 active site 1173025012156 motif 3; other site 1173025012157 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 1173025012158 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1173025012159 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1173025012160 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1173025012161 putative dimer interface [polypeptide binding]; other site 1173025012162 N-terminal domain interface [polypeptide binding]; other site 1173025012163 putative substrate binding pocket (H-site) [chemical binding]; other site 1173025012164 glycogen synthase; Provisional; Region: glgA; PRK00654 1173025012165 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1173025012166 ADP-binding pocket [chemical binding]; other site 1173025012167 homodimer interface [polypeptide binding]; other site 1173025012168 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 1173025012169 putative ADP-binding pocket [chemical binding]; other site 1173025012170 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173025012171 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173025012172 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1173025012173 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1173025012174 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173025012175 active site 1173025012176 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 1173025012177 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1173025012178 active site 1173025012179 substrate binding site [chemical binding]; other site 1173025012180 metal binding site [ion binding]; metal-binding site 1173025012181 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 1173025012182 CP12 domain; Region: CP12; pfam02672 1173025012183 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 1173025012184 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173025012185 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1173025012186 Probable transposase; Region: OrfB_IS605; pfam01385 1173025012187 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173025012188 CHAT domain; Region: CHAT; pfam12770 1173025012189 Predicted transcriptional regulators [Transcription]; Region: COG1733 1173025012190 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173025012191 dimerization interface [polypeptide binding]; other site 1173025012192 putative DNA binding site [nucleotide binding]; other site 1173025012193 putative Zn2+ binding site [ion binding]; other site 1173025012194 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 1173025012195 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 1173025012196 Pirin-related protein [General function prediction only]; Region: COG1741 1173025012197 Pirin; Region: Pirin; pfam02678 1173025012198 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173025012199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173025012200 active site 1173025012201 phosphorylation site [posttranslational modification] 1173025012202 intermolecular recognition site; other site 1173025012203 dimerization interface [polypeptide binding]; other site 1173025012204 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173025012205 DNA binding site [nucleotide binding] 1173025012206 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1173025012207 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1173025012208 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173025012209 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173025012210 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1173025012211 Walker A/P-loop; other site 1173025012212 ATP binding site [chemical binding]; other site 1173025012213 Q-loop/lid; other site 1173025012214 ABC transporter signature motif; other site 1173025012215 Walker B; other site 1173025012216 D-loop; other site 1173025012217 H-loop/switch region; other site 1173025012218 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1173025012219 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1173025012220 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1173025012221 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1173025012222 homotetramer interface [polypeptide binding]; other site 1173025012223 ligand binding site [chemical binding]; other site 1173025012224 catalytic site [active] 1173025012225 NAD binding site [chemical binding]; other site 1173025012226 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1173025012227 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025012228 binding surface 1173025012229 TPR motif; other site 1173025012230 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025012231 binding surface 1173025012232 TPR motif; other site 1173025012233 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1173025012234 RNA/DNA hybrid binding site [nucleotide binding]; other site 1173025012235 active site 1173025012236 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1173025012237 dimer interface [polypeptide binding]; other site 1173025012238 substrate binding site [chemical binding]; other site 1173025012239 ATP binding site [chemical binding]; other site 1173025012240 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1173025012241 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 1173025012242 cell division protein FtsZ; Validated; Region: PRK09330 1173025012243 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1173025012244 nucleotide binding site [chemical binding]; other site 1173025012245 SulA interaction site; other site 1173025012246 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1173025012247 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1173025012248 germination protein YpeB; Region: spore_YpeB; TIGR02889 1173025012249 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 1173025012250 active site 1173025012251 catalytic triad [active] 1173025012252 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1173025012253 Cytochrome c; Region: Cytochrom_C; cl11414 1173025012254 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173025012255 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173025012256 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1173025012257 Walker A/P-loop; other site 1173025012258 ATP binding site [chemical binding]; other site 1173025012259 Q-loop/lid; other site 1173025012260 ABC transporter signature motif; other site 1173025012261 Walker B; other site 1173025012262 D-loop; other site 1173025012263 H-loop/switch region; other site 1173025012264 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1173025012265 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1173025012266 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1173025012267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173025012268 S-adenosylmethionine binding site [chemical binding]; other site 1173025012269 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1173025012270 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1173025012271 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 1173025012272 Ligand Binding Site [chemical binding]; other site 1173025012273 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1173025012274 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1173025012275 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1173025012276 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 1173025012277 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1173025012278 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173025012279 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1173025012280 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173025012281 DNA binding residues [nucleotide binding] 1173025012282 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1173025012283 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173025012284 Coenzyme A binding pocket [chemical binding]; other site 1173025012285 Ion channel; Region: Ion_trans_2; pfam07885 1173025012286 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1173025012287 TrkA-N domain; Region: TrkA_N; pfam02254 1173025012288 TrkA-C domain; Region: TrkA_C; pfam02080 1173025012289 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025012290 binding surface 1173025012291 TPR motif; other site 1173025012292 TPR repeat; Region: TPR_11; pfam13414 1173025012293 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025012294 binding surface 1173025012295 TPR motif; other site 1173025012296 TPR repeat; Region: TPR_11; pfam13414 1173025012297 TPR repeat; Region: TPR_11; pfam13414 1173025012298 TPR repeat; Region: TPR_11; pfam13414 1173025012299 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025012300 binding surface 1173025012301 TPR motif; other site 1173025012302 TPR repeat; Region: TPR_11; pfam13414 1173025012303 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1173025012304 substrate binding site [chemical binding]; other site 1173025012305 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 1173025012306 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1173025012307 active site 1173025012308 putative substrate binding pocket [chemical binding]; other site 1173025012309 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1173025012310 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1173025012311 putative glycosyl transferase; Provisional; Region: PRK10307 1173025012312 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1173025012313 acylphosphatase; Provisional; Region: PRK14423 1173025012314 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1173025012315 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1173025012316 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1173025012317 anti sigma factor interaction site; other site 1173025012318 regulatory phosphorylation site [posttranslational modification]; other site 1173025012319 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1173025012320 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1173025012321 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1173025012322 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1173025012323 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1173025012324 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1173025012325 catalytic motif [active] 1173025012326 Catalytic residue [active] 1173025012327 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1173025012328 catalytic motif [active] 1173025012329 Catalytic residue [active] 1173025012330 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1173025012331 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1173025012332 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1173025012333 catalytic site [active] 1173025012334 subunit interface [polypeptide binding]; other site 1173025012335 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1173025012336 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1173025012337 anti sigma factor interaction site; other site 1173025012338 regulatory phosphorylation site [posttranslational modification]; other site 1173025012339 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 1173025012340 dimerization interface [polypeptide binding]; other site 1173025012341 active site 1173025012342 metal binding site [ion binding]; metal-binding site 1173025012343 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1173025012344 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1173025012345 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1173025012346 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 1173025012347 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173025012348 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1173025012349 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1173025012350 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1173025012351 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1173025012352 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1173025012353 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1173025012354 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173025012355 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1173025012356 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1173025012357 trimer interface [polypeptide binding]; other site 1173025012358 active site 1173025012359 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1173025012360 trimer interface [polypeptide binding]; other site 1173025012361 active site 1173025012362 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1173025012363 cob(I)yrinic acid a,c-diamide adenosyltransferase; Validated; Region: PRK07414 1173025012364 ribonuclease PH; Reviewed; Region: rph; PRK00173 1173025012365 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1173025012366 hexamer interface [polypeptide binding]; other site 1173025012367 active site 1173025012368 photochlorophyllide reductase subunit B; Region: chlB; CHL00076 1173025012369 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 1173025012370 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 1173025012371 Uncharacterized conserved protein [Function unknown]; Region: COG3937 1173025012372 ribulose bisphosphate carboxylase/oxygenase activase -RuBisCO activase (RCA); Provisional; Region: PLN00020 1173025012373 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 1173025012374 putative multimerization interface [polypeptide binding]; other site 1173025012375 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 1173025012376 multimerization interface [polypeptide binding]; other site 1173025012377 RbcX protein; Region: RcbX; pfam02341 1173025012378 ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040 1173025012379 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 1173025012380 homodimer interface [polypeptide binding]; other site 1173025012381 active site 1173025012382 heterodimer interface [polypeptide binding]; other site 1173025012383 catalytic residue [active] 1173025012384 metal binding site [ion binding]; metal-binding site 1173025012385 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 1173025012386 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 1173025012387 AIR carboxylase; Region: AIRC; pfam00731 1173025012388 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1173025012389 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1173025012390 active site 1173025012391 dimer interface [polypeptide binding]; other site 1173025012392 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 1173025012393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1173025012394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173025012395 S-adenosylmethionine binding site [chemical binding]; other site 1173025012396 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 1173025012397 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1173025012398 L11 interface [polypeptide binding]; other site 1173025012399 putative EF-Tu interaction site [polypeptide binding]; other site 1173025012400 putative EF-G interaction site [polypeptide binding]; other site 1173025012401 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1173025012402 oligomerization interface [polypeptide binding]; other site 1173025012403 active site 1173025012404 metal binding site [ion binding]; metal-binding site 1173025012405 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173025012406 non-specific DNA binding site [nucleotide binding]; other site 1173025012407 salt bridge; other site 1173025012408 sequence-specific DNA binding site [nucleotide binding]; other site 1173025012409 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1173025012410 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 1173025012411 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1173025012412 Predicted membrane protein [Function unknown]; Region: COG2119 1173025012413 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1173025012414 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 1173025012415 Photosystem II complex subunit Ycf12; Region: PSII_Ycf12; cl12139 1173025012416 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025012417 GAF domain; Region: GAF_2; pfam13185 1173025012418 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173025012419 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173025012420 PAS domain; Region: PAS; smart00091 1173025012421 putative active site [active] 1173025012422 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173025012423 cyclase homology domain; Region: CHD; cd07302 1173025012424 nucleotidyl binding site; other site 1173025012425 metal binding site [ion binding]; metal-binding site 1173025012426 dimer interface [polypeptide binding]; other site 1173025012427 TPR repeat; Region: TPR_11; pfam13414 1173025012428 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173025012429 binding surface 1173025012430 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 1173025012431 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1173025012432 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173025012433 dimerization interface [polypeptide binding]; other site 1173025012434 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173025012435 PAS domain; Region: PAS; smart00091 1173025012436 putative active site [active] 1173025012437 heme pocket [chemical binding]; other site 1173025012438 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025012439 dimer interface [polypeptide binding]; other site 1173025012440 phosphorylation site [posttranslational modification] 1173025012441 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025012442 ATP binding site [chemical binding]; other site 1173025012443 Mg2+ binding site [ion binding]; other site 1173025012444 G-X-G motif; other site 1173025012445 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1173025012446 active site 1173025012447 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173025012448 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025012449 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025012450 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173025012451 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025012452 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173025012453 Uncharacterized conserved protein [Function unknown]; Region: COG2006 1173025012454 Domain of unknown function (DUF362); Region: DUF362; pfam04015 1173025012455 S-layer homology domain; Region: SLH; pfam00395 1173025012456 S-layer homology domain; Region: SLH; pfam00395 1173025012457 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1173025012458 active site 1173025012459 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1173025012460 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1173025012461 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1173025012462 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1173025012463 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1173025012464 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1173025012465 active site 1173025012466 catalytic residues [active] 1173025012467 metal binding site [ion binding]; metal-binding site 1173025012468 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173025012469 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173025012470 phosphopeptide binding site; other site 1173025012471 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 1173025012472 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 1173025012473 DctM-like transporters; Region: DctM; pfam06808 1173025012474 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 1173025012475 FAD binding domain; Region: FAD_binding_1; pfam00667 1173025012476 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1173025012477 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1173025012478 phosphoenolpyruvate synthase; Region: PEP_synth; TIGR01418 1173025012479 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1173025012480 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1173025012481 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1173025012482 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1173025012483 Walker A/P-loop; other site 1173025012484 ATP binding site [chemical binding]; other site 1173025012485 Q-loop/lid; other site 1173025012486 ABC transporter signature motif; other site 1173025012487 Walker B; other site 1173025012488 D-loop; other site 1173025012489 H-loop/switch region; other site 1173025012490 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1173025012491 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1173025012492 Walker A/P-loop; other site 1173025012493 ATP binding site [chemical binding]; other site 1173025012494 Q-loop/lid; other site 1173025012495 ABC transporter signature motif; other site 1173025012496 Walker B; other site 1173025012497 D-loop; other site 1173025012498 H-loop/switch region; other site 1173025012499 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1173025012500 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173025012501 dimer interface [polypeptide binding]; other site 1173025012502 phosphorylation site [posttranslational modification] 1173025012503 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173025012504 ATP binding site [chemical binding]; other site 1173025012505 Mg2+ binding site [ion binding]; other site 1173025012506 G-X-G motif; other site 1173025012507 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1173025012508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173025012509 dimer interface [polypeptide binding]; other site 1173025012510 conserved gate region; other site 1173025012511 putative PBP binding loops; other site 1173025012512 ABC-ATPase subunit interface; other site 1173025012513 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1173025012514 NMT1-like family; Region: NMT1_2; pfam13379 1173025012515 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1173025012516 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 1173025012517 Walker A/P-loop; other site 1173025012518 ATP binding site [chemical binding]; other site 1173025012519 Q-loop/lid; other site 1173025012520 ABC transporter signature motif; other site 1173025012521 Walker B; other site 1173025012522 D-loop; other site 1173025012523 H-loop/switch region; other site 1173025012524 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1173025012525 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173025012526 Walker A/P-loop; other site 1173025012527 ATP binding site [chemical binding]; other site 1173025012528 Q-loop/lid; other site 1173025012529 ABC transporter signature motif; other site 1173025012530 Walker B; other site 1173025012531 D-loop; other site 1173025012532 H-loop/switch region; other site 1173025012533 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1173025012534 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533