-- dump date 20140619_101112 -- class Genbank::misc_feature -- table misc_feature_note -- id note 691437000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 691437000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 691437000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437000004 Walker A motif; other site 691437000005 ATP binding site [chemical binding]; other site 691437000006 Walker B motif; other site 691437000007 arginine finger; other site 691437000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 691437000009 DnaA box-binding interface [nucleotide binding]; other site 691437000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 691437000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 691437000012 putative DNA binding surface [nucleotide binding]; other site 691437000013 dimer interface [polypeptide binding]; other site 691437000014 beta-clamp/clamp loader binding surface; other site 691437000015 beta-clamp/translesion DNA polymerase binding surface; other site 691437000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 691437000017 recombination protein F; Reviewed; Region: recF; PRK00064 691437000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 691437000019 Walker A/P-loop; other site 691437000020 ATP binding site [chemical binding]; other site 691437000021 Q-loop/lid; other site 691437000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 691437000023 ABC transporter signature motif; other site 691437000024 Walker B; other site 691437000025 D-loop; other site 691437000026 H-loop/switch region; other site 691437000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 691437000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437000029 Mg2+ binding site [ion binding]; other site 691437000030 G-X-G motif; other site 691437000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 691437000032 anchoring element; other site 691437000033 dimer interface [polypeptide binding]; other site 691437000034 ATP binding site [chemical binding]; other site 691437000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 691437000036 active site 691437000037 putative metal-binding site [ion binding]; other site 691437000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 691437000039 DNA gyrase subunit A; Validated; Region: PRK05560 691437000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 691437000041 CAP-like domain; other site 691437000042 active site 691437000043 primary dimer interface [polypeptide binding]; other site 691437000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 691437000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 691437000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 691437000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 691437000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 691437000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 691437000050 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 691437000051 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 691437000052 Zn2+ binding site [ion binding]; other site 691437000053 Mg2+ binding site [ion binding]; other site 691437000054 YaaC-like Protein; Region: YaaC; pfam14175 691437000055 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 691437000056 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 691437000057 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 691437000058 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 691437000059 active site 691437000060 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 691437000061 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 691437000062 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 691437000063 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 691437000064 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 691437000065 active site 691437000066 multimer interface [polypeptide binding]; other site 691437000067 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 691437000068 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 691437000069 predicted active site [active] 691437000070 catalytic triad [active] 691437000071 seryl-tRNA synthetase; Provisional; Region: PRK05431 691437000072 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 691437000073 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 691437000074 dimer interface [polypeptide binding]; other site 691437000075 active site 691437000076 motif 1; other site 691437000077 motif 2; other site 691437000078 motif 3; other site 691437000079 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 691437000080 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 691437000081 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 691437000082 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 691437000083 active site 691437000084 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 691437000085 nucleoside/Zn binding site; other site 691437000086 dimer interface [polypeptide binding]; other site 691437000087 catalytic motif [active] 691437000088 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 691437000089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437000090 Walker A motif; other site 691437000091 ATP binding site [chemical binding]; other site 691437000092 Walker B motif; other site 691437000093 arginine finger; other site 691437000094 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 691437000095 hypothetical protein; Validated; Region: PRK00153 691437000096 recombination protein RecR; Reviewed; Region: recR; PRK00076 691437000097 RecR protein; Region: RecR; pfam02132 691437000098 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 691437000099 putative active site [active] 691437000100 putative metal-binding site [ion binding]; other site 691437000101 tetramer interface [polypeptide binding]; other site 691437000102 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 691437000103 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 691437000104 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 691437000105 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 691437000106 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 691437000107 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 691437000108 catalytic residue [active] 691437000109 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 691437000110 thymidylate kinase; Validated; Region: tmk; PRK00698 691437000111 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 691437000112 TMP-binding site; other site 691437000113 ATP-binding site [chemical binding]; other site 691437000114 DNA polymerase III subunit delta'; Validated; Region: PRK08058 691437000115 DNA polymerase III subunit delta'; Validated; Region: PRK08485 691437000116 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 691437000117 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 691437000118 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 691437000119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437000120 S-adenosylmethionine binding site [chemical binding]; other site 691437000121 Predicted methyltransferases [General function prediction only]; Region: COG0313 691437000122 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 691437000123 putative SAM binding site [chemical binding]; other site 691437000124 putative homodimer interface [polypeptide binding]; other site 691437000125 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 691437000126 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 691437000127 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 691437000128 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 691437000129 active site 691437000130 HIGH motif; other site 691437000131 KMSKS motif; other site 691437000132 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 691437000133 tRNA binding surface [nucleotide binding]; other site 691437000134 anticodon binding site; other site 691437000135 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 691437000136 dimer interface [polypeptide binding]; other site 691437000137 putative tRNA-binding site [nucleotide binding]; other site 691437000138 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 691437000139 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 691437000140 active site 691437000141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 691437000142 Domain of unknown function (DUF348); Region: DUF348; pfam03990 691437000143 Domain of unknown function (DUF348); Region: DUF348; pfam03990 691437000144 Domain of unknown function (DUF348); Region: DUF348; pfam03990 691437000145 G5 domain; Region: G5; pfam07501 691437000146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 691437000147 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 691437000148 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 691437000149 putative active site [active] 691437000150 putative metal binding site [ion binding]; other site 691437000151 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 691437000152 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 691437000153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437000154 S-adenosylmethionine binding site [chemical binding]; other site 691437000155 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 691437000156 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 691437000157 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 691437000158 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 691437000159 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 691437000160 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 691437000161 pur operon repressor; Provisional; Region: PRK09213 691437000162 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 691437000163 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 691437000164 active site 691437000165 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 691437000166 homotrimer interaction site [polypeptide binding]; other site 691437000167 putative active site [active] 691437000168 regulatory protein SpoVG; Reviewed; Region: PRK13259 691437000169 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 691437000170 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 691437000171 Substrate binding site; other site 691437000172 Mg++ binding site; other site 691437000173 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 691437000174 active site 691437000175 substrate binding site [chemical binding]; other site 691437000176 CoA binding site [chemical binding]; other site 691437000177 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 691437000178 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 691437000179 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 691437000180 active site 691437000181 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 691437000182 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 691437000183 5S rRNA interface [nucleotide binding]; other site 691437000184 CTC domain interface [polypeptide binding]; other site 691437000185 L16 interface [polypeptide binding]; other site 691437000186 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 691437000187 putative active site [active] 691437000188 catalytic residue [active] 691437000189 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 691437000190 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 691437000191 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 691437000192 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 691437000193 ATP binding site [chemical binding]; other site 691437000194 putative Mg++ binding site [ion binding]; other site 691437000195 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 691437000196 nucleotide binding region [chemical binding]; other site 691437000197 ATP-binding site [chemical binding]; other site 691437000198 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 691437000199 stage V sporulation protein T; Region: spore_V_T; TIGR02851 691437000200 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 691437000201 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 691437000202 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 691437000203 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 691437000204 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 691437000205 putative SAM binding site [chemical binding]; other site 691437000206 putative homodimer interface [polypeptide binding]; other site 691437000207 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 691437000208 homodimer interface [polypeptide binding]; other site 691437000209 metal binding site [ion binding]; metal-binding site 691437000210 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 691437000211 homodimer interface [polypeptide binding]; other site 691437000212 active site 691437000213 putative chemical substrate binding site [chemical binding]; other site 691437000214 metal binding site [ion binding]; metal-binding site 691437000215 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 691437000216 RNA binding surface [nucleotide binding]; other site 691437000217 sporulation protein YabP; Region: spore_yabP; TIGR02892 691437000218 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 691437000219 Septum formation initiator; Region: DivIC; pfam04977 691437000220 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 691437000221 hypothetical protein; Provisional; Region: PRK08582 691437000222 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 691437000223 RNA binding site [nucleotide binding]; other site 691437000224 stage II sporulation protein E; Region: spore_II_E; TIGR02865 691437000225 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 691437000226 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 691437000227 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 691437000228 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 691437000229 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 691437000230 metal ion-dependent adhesion site (MIDAS); other site 691437000231 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 691437000232 Catalytic domain of Protein Kinases; Region: PKc; cd00180 691437000233 active site 691437000234 ATP binding site [chemical binding]; other site 691437000235 substrate binding site [chemical binding]; other site 691437000236 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 691437000237 active site 691437000238 ATP binding site [chemical binding]; other site 691437000239 substrate binding site [chemical binding]; other site 691437000240 activation loop (A-loop); other site 691437000241 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 691437000242 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 691437000243 Ligand Binding Site [chemical binding]; other site 691437000244 TilS substrate C-terminal domain; Region: TilS_C; smart00977 691437000245 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 691437000246 active site 691437000247 FtsH Extracellular; Region: FtsH_ext; pfam06480 691437000248 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 691437000249 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437000250 Walker A motif; other site 691437000251 ATP binding site [chemical binding]; other site 691437000252 Walker B motif; other site 691437000253 arginine finger; other site 691437000254 Peptidase family M41; Region: Peptidase_M41; pfam01434 691437000255 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 691437000256 nucleotide binding site [chemical binding]; other site 691437000257 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 691437000258 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 691437000259 dimerization interface [polypeptide binding]; other site 691437000260 domain crossover interface; other site 691437000261 redox-dependent activation switch; other site 691437000262 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 691437000263 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 691437000264 dimer interface [polypeptide binding]; other site 691437000265 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437000266 catalytic residue [active] 691437000267 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 691437000268 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 691437000269 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 691437000270 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 691437000271 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 691437000272 glutamine binding [chemical binding]; other site 691437000273 catalytic triad [active] 691437000274 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 691437000275 4-amino-4-deoxychorismate lyase; Provisional; Region: PRK07650 691437000276 homodimer interface [polypeptide binding]; other site 691437000277 substrate-cofactor binding pocket; other site 691437000278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437000279 catalytic residue [active] 691437000280 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 691437000281 dihydropteroate synthase; Region: DHPS; TIGR01496 691437000282 substrate binding pocket [chemical binding]; other site 691437000283 dimer interface [polypeptide binding]; other site 691437000284 inhibitor binding site; inhibition site 691437000285 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 691437000286 homooctamer interface [polypeptide binding]; other site 691437000287 active site 691437000288 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 691437000289 catalytic center binding site [active] 691437000290 ATP binding site [chemical binding]; other site 691437000291 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 691437000292 non-specific DNA binding site [nucleotide binding]; other site 691437000293 salt bridge; other site 691437000294 sequence-specific DNA binding site [nucleotide binding]; other site 691437000295 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 691437000296 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 691437000297 FMN binding site [chemical binding]; other site 691437000298 active site 691437000299 catalytic residues [active] 691437000300 substrate binding site [chemical binding]; other site 691437000301 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 691437000302 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 691437000303 dimer interface [polypeptide binding]; other site 691437000304 putative anticodon binding site; other site 691437000305 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 691437000306 motif 1; other site 691437000307 active site 691437000308 motif 2; other site 691437000309 motif 3; other site 691437000310 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 691437000311 putative trimer interface [polypeptide binding]; other site 691437000312 putative CoA binding site [chemical binding]; other site 691437000313 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 691437000314 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 691437000315 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 691437000316 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 691437000317 ADP binding site [chemical binding]; other site 691437000318 phosphagen binding site; other site 691437000319 substrate specificity loop; other site 691437000320 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 691437000321 Clp amino terminal domain; Region: Clp_N; pfam02861 691437000322 Clp amino terminal domain; Region: Clp_N; pfam02861 691437000323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437000324 Walker A motif; other site 691437000325 ATP binding site [chemical binding]; other site 691437000326 Walker B motif; other site 691437000327 arginine finger; other site 691437000328 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437000329 Walker A motif; other site 691437000330 ATP binding site [chemical binding]; other site 691437000331 Walker B motif; other site 691437000332 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 691437000333 DNA repair protein RadA; Provisional; Region: PRK11823 691437000334 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 691437000335 Walker A motif/ATP binding site; other site 691437000336 ATP binding site [chemical binding]; other site 691437000337 Walker B motif; other site 691437000338 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 691437000339 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 691437000340 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 691437000341 putative active site [active] 691437000342 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 691437000343 substrate binding site; other site 691437000344 dimer interface; other site 691437000345 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 691437000346 homotrimer interaction site [polypeptide binding]; other site 691437000347 zinc binding site [ion binding]; other site 691437000348 CDP-binding sites; other site 691437000349 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 691437000350 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 691437000351 HIGH motif; other site 691437000352 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 691437000353 active site 691437000354 KMSKS motif; other site 691437000355 serine O-acetyltransferase; Region: cysE; TIGR01172 691437000356 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 691437000357 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 691437000358 trimer interface [polypeptide binding]; other site 691437000359 active site 691437000360 substrate binding site [chemical binding]; other site 691437000361 CoA binding site [chemical binding]; other site 691437000362 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 691437000363 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 691437000364 active site 691437000365 HIGH motif; other site 691437000366 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 691437000367 KMSKS motif; other site 691437000368 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 691437000369 tRNA binding surface [nucleotide binding]; other site 691437000370 anticodon binding site; other site 691437000371 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 691437000372 active site 691437000373 metal binding site [ion binding]; metal-binding site 691437000374 dimerization interface [polypeptide binding]; other site 691437000375 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 691437000376 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 691437000377 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 691437000378 YacP-like NYN domain; Region: NYN_YacP; cl01491 691437000379 RNA polymerase factor sigma-70; Validated; Region: PRK08295 691437000380 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 691437000381 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 691437000382 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 691437000383 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 691437000384 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 691437000385 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 691437000386 putative homodimer interface [polypeptide binding]; other site 691437000387 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 691437000388 heterodimer interface [polypeptide binding]; other site 691437000389 homodimer interface [polypeptide binding]; other site 691437000390 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 691437000391 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 691437000392 23S rRNA interface [nucleotide binding]; other site 691437000393 L7/L12 interface [polypeptide binding]; other site 691437000394 putative thiostrepton binding site; other site 691437000395 L25 interface [polypeptide binding]; other site 691437000396 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 691437000397 mRNA/rRNA interface [nucleotide binding]; other site 691437000398 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 691437000399 23S rRNA interface [nucleotide binding]; other site 691437000400 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 691437000401 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 691437000402 core dimer interface [polypeptide binding]; other site 691437000403 peripheral dimer interface [polypeptide binding]; other site 691437000404 L10 interface [polypeptide binding]; other site 691437000405 L11 interface [polypeptide binding]; other site 691437000406 putative EF-Tu interaction site [polypeptide binding]; other site 691437000407 putative EF-G interaction site [polypeptide binding]; other site 691437000408 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 691437000409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437000410 S-adenosylmethionine binding site [chemical binding]; other site 691437000411 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 691437000412 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 691437000413 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 691437000414 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 691437000415 RPB1 interaction site [polypeptide binding]; other site 691437000416 RPB10 interaction site [polypeptide binding]; other site 691437000417 RPB11 interaction site [polypeptide binding]; other site 691437000418 RPB3 interaction site [polypeptide binding]; other site 691437000419 RPB12 interaction site [polypeptide binding]; other site 691437000420 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 691437000421 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 691437000422 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 691437000423 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 691437000424 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 691437000425 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 691437000426 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 691437000427 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 691437000428 G-loop; other site 691437000429 DNA binding site [nucleotide binding] 691437000430 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 691437000431 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 691437000432 S17 interaction site [polypeptide binding]; other site 691437000433 S8 interaction site; other site 691437000434 16S rRNA interaction site [nucleotide binding]; other site 691437000435 streptomycin interaction site [chemical binding]; other site 691437000436 23S rRNA interaction site [nucleotide binding]; other site 691437000437 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 691437000438 30S ribosomal protein S7; Validated; Region: PRK05302 691437000439 elongation factor G; Reviewed; Region: PRK00007 691437000440 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 691437000441 G1 box; other site 691437000442 putative GEF interaction site [polypeptide binding]; other site 691437000443 GTP/Mg2+ binding site [chemical binding]; other site 691437000444 Switch I region; other site 691437000445 G2 box; other site 691437000446 G3 box; other site 691437000447 Switch II region; other site 691437000448 G4 box; other site 691437000449 G5 box; other site 691437000450 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 691437000451 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 691437000452 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 691437000453 elongation factor Tu; Reviewed; Region: PRK00049 691437000454 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 691437000455 G1 box; other site 691437000456 GEF interaction site [polypeptide binding]; other site 691437000457 GTP/Mg2+ binding site [chemical binding]; other site 691437000458 Switch I region; other site 691437000459 G2 box; other site 691437000460 G3 box; other site 691437000461 Switch II region; other site 691437000462 G4 box; other site 691437000463 G5 box; other site 691437000464 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 691437000465 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 691437000466 Antibiotic Binding Site [chemical binding]; other site 691437000467 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 691437000468 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 691437000469 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 691437000470 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 691437000471 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 691437000472 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 691437000473 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 691437000474 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 691437000475 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 691437000476 putative translocon binding site; other site 691437000477 protein-rRNA interface [nucleotide binding]; other site 691437000478 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 691437000479 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 691437000480 G-X-X-G motif; other site 691437000481 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 691437000482 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 691437000483 23S rRNA interface [nucleotide binding]; other site 691437000484 5S rRNA interface [nucleotide binding]; other site 691437000485 putative antibiotic binding site [chemical binding]; other site 691437000486 L25 interface [polypeptide binding]; other site 691437000487 L27 interface [polypeptide binding]; other site 691437000488 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 691437000489 23S rRNA interface [nucleotide binding]; other site 691437000490 putative translocon interaction site; other site 691437000491 signal recognition particle (SRP54) interaction site; other site 691437000492 L23 interface [polypeptide binding]; other site 691437000493 trigger factor interaction site; other site 691437000494 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 691437000495 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 691437000496 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 691437000497 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 691437000498 RNA binding site [nucleotide binding]; other site 691437000499 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 691437000500 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 691437000501 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 691437000502 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 691437000503 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 691437000504 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 691437000505 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 691437000506 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 691437000507 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 691437000508 5S rRNA interface [nucleotide binding]; other site 691437000509 L27 interface [polypeptide binding]; other site 691437000510 23S rRNA interface [nucleotide binding]; other site 691437000511 L5 interface [polypeptide binding]; other site 691437000512 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 691437000513 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 691437000514 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 691437000515 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 691437000516 23S rRNA binding site [nucleotide binding]; other site 691437000517 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 691437000518 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 691437000519 SecY translocase; Region: SecY; pfam00344 691437000520 adenylate kinase; Reviewed; Region: adk; PRK00279 691437000521 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 691437000522 AMP-binding site [chemical binding]; other site 691437000523 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 691437000524 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 691437000525 active site 691437000526 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 691437000527 rRNA binding site [nucleotide binding]; other site 691437000528 predicted 30S ribosome binding site; other site 691437000529 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 691437000530 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 691437000531 30S ribosomal protein S13; Region: bact_S13; TIGR03631 691437000532 30S ribosomal protein S11; Validated; Region: PRK05309 691437000533 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 691437000534 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 691437000535 alphaNTD - beta interaction site [polypeptide binding]; other site 691437000536 alphaNTD homodimer interface [polypeptide binding]; other site 691437000537 alphaNTD - beta' interaction site [polypeptide binding]; other site 691437000538 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 691437000539 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 691437000540 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 691437000541 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 691437000542 Walker A/P-loop; other site 691437000543 ATP binding site [chemical binding]; other site 691437000544 Q-loop/lid; other site 691437000545 ABC transporter signature motif; other site 691437000546 Walker B; other site 691437000547 D-loop; other site 691437000548 H-loop/switch region; other site 691437000549 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 691437000550 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 691437000551 Walker A/P-loop; other site 691437000552 ATP binding site [chemical binding]; other site 691437000553 Q-loop/lid; other site 691437000554 ABC transporter signature motif; other site 691437000555 Walker B; other site 691437000556 D-loop; other site 691437000557 H-loop/switch region; other site 691437000558 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 691437000559 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 691437000560 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 691437000561 dimerization interface 3.5A [polypeptide binding]; other site 691437000562 active site 691437000563 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 691437000564 23S rRNA interface [nucleotide binding]; other site 691437000565 L3 interface [polypeptide binding]; other site 691437000566 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 691437000567 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 691437000568 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 691437000569 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 691437000570 active site 691437000571 Domain of unknown function DUF59; Region: DUF59; cl00941 691437000572 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 691437000573 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 691437000574 Walker A motif; other site 691437000575 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 691437000576 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 691437000577 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 691437000578 Arginase family; Region: Arginase; cd09989 691437000579 agmatinase; Region: agmatinase; TIGR01230 691437000580 active site 691437000581 Mn binding site [ion binding]; other site 691437000582 oligomer interface [polypeptide binding]; other site 691437000583 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 691437000584 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 691437000585 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 691437000586 DNA binding residues [nucleotide binding] 691437000587 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 691437000588 Putative zinc-finger; Region: zf-HC2; pfam13490 691437000589 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 691437000590 Uncharacterized conserved protein [Function unknown]; Region: COG1624 691437000591 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 691437000592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 691437000593 YbbR-like protein; Region: YbbR; pfam07949 691437000594 YbbR-like protein; Region: YbbR; pfam07949 691437000595 YbbR-like protein; Region: YbbR; pfam07949 691437000596 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 691437000597 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 691437000598 active site 691437000599 substrate binding site [chemical binding]; other site 691437000600 metal binding site [ion binding]; metal-binding site 691437000601 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 691437000602 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 691437000603 glutaminase active site [active] 691437000604 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 691437000605 dimer interface [polypeptide binding]; other site 691437000606 active site 691437000607 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 691437000608 dimer interface [polypeptide binding]; other site 691437000609 active site 691437000610 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 691437000611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437000612 dimer interface [polypeptide binding]; other site 691437000613 conserved gate region; other site 691437000614 ABC-ATPase subunit interface; other site 691437000615 uridine kinase; Provisional; Region: PRK07667 691437000616 active site 691437000617 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 691437000618 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 691437000619 salt bridge; other site 691437000620 non-specific DNA binding site [nucleotide binding]; other site 691437000621 sequence-specific DNA binding site [nucleotide binding]; other site 691437000622 Protein of unknown function (DUF817); Region: DUF817; pfam05675 691437000623 DinB superfamily; Region: DinB_2; pfam12867 691437000624 metal-dependent hydrolase; Provisional; Region: PRK13291 691437000625 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 691437000626 active site 691437000627 PAS fold; Region: PAS; pfam00989 691437000628 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 691437000629 putative active site [active] 691437000630 heme pocket [chemical binding]; other site 691437000631 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 691437000632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437000633 Walker A motif; other site 691437000634 ATP binding site [chemical binding]; other site 691437000635 Walker B motif; other site 691437000636 arginine finger; other site 691437000637 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 691437000638 S-methylmethionine transporter; Provisional; Region: PRK11387 691437000639 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 691437000640 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 691437000641 Glutamate binding site [chemical binding]; other site 691437000642 homodimer interface [polypeptide binding]; other site 691437000643 NAD binding site [chemical binding]; other site 691437000644 catalytic residues [active] 691437000645 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 691437000646 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 691437000647 inhibitor-cofactor binding pocket; inhibition site 691437000648 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437000649 catalytic residue [active] 691437000650 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 691437000651 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 691437000652 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 691437000653 NAD(P) binding site [chemical binding]; other site 691437000654 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 691437000655 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 691437000656 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 691437000657 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 691437000658 dimer interface [polypeptide binding]; other site 691437000659 putative PBP binding regions; other site 691437000660 ABC-ATPase subunit interface; other site 691437000661 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 691437000662 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 691437000663 ABC-ATPase subunit interface; other site 691437000664 dimer interface [polypeptide binding]; other site 691437000665 putative PBP binding regions; other site 691437000666 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 691437000667 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 691437000668 putative ligand binding residues [chemical binding]; other site 691437000669 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 691437000670 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 691437000671 Walker A/P-loop; other site 691437000672 ATP binding site [chemical binding]; other site 691437000673 Q-loop/lid; other site 691437000674 ABC transporter signature motif; other site 691437000675 Walker B; other site 691437000676 D-loop; other site 691437000677 H-loop/switch region; other site 691437000678 FOG: CBS domain [General function prediction only]; Region: COG0517 691437000679 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 691437000680 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 691437000681 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 691437000682 putative active site [active] 691437000683 heme pocket [chemical binding]; other site 691437000684 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437000685 Walker A motif; other site 691437000686 ATP binding site [chemical binding]; other site 691437000687 Walker B motif; other site 691437000688 arginine finger; other site 691437000689 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 691437000690 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 691437000691 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 691437000692 active site 691437000693 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 691437000694 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 691437000695 NAD(P) binding site [chemical binding]; other site 691437000696 catalytic residues [active] 691437000697 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 691437000698 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 691437000699 active site 691437000700 metal binding site [ion binding]; metal-binding site 691437000701 Predicted membrane protein [Function unknown]; Region: COG2259 691437000702 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 691437000703 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 691437000704 catalytic residues [active] 691437000705 DinB family; Region: DinB; cl17821 691437000706 DinB superfamily; Region: DinB_2; pfam12867 691437000707 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 691437000708 Histidine kinase; Region: HisKA_3; pfam07730 691437000709 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 691437000710 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 691437000711 Walker A/P-loop; other site 691437000712 ATP binding site [chemical binding]; other site 691437000713 Q-loop/lid; other site 691437000714 ABC transporter signature motif; other site 691437000715 Walker B; other site 691437000716 D-loop; other site 691437000717 H-loop/switch region; other site 691437000718 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 691437000719 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 691437000720 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 691437000721 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 691437000722 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 691437000723 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 691437000724 active site 691437000725 metal binding site [ion binding]; metal-binding site 691437000726 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 691437000727 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 691437000728 active site 691437000729 catalytic triad [active] 691437000730 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 691437000731 Sulfatase; Region: Sulfatase; pfam00884 691437000732 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 691437000733 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 691437000734 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 691437000735 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 691437000736 Domain of unknown function DUF; Region: DUF204; pfam02659 691437000737 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 691437000738 SpoOM protein; Region: Spo0M; pfam07070 691437000739 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 691437000740 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 691437000741 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 691437000742 nucleotide binding site [chemical binding]; other site 691437000743 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 691437000744 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 691437000745 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 691437000746 active site 691437000747 homodimer interface [polypeptide binding]; other site 691437000748 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 691437000749 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 691437000750 NodB motif; other site 691437000751 putative active site [active] 691437000752 putative catalytic site [active] 691437000753 putative Zn binding site [ion binding]; other site 691437000754 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 691437000755 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 691437000756 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 691437000757 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 691437000758 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 691437000759 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 691437000760 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 691437000761 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 691437000762 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 691437000763 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 691437000764 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 691437000765 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 691437000766 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 691437000767 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 691437000768 ATP binding site [chemical binding]; other site 691437000769 Mg++ binding site [ion binding]; other site 691437000770 motif III; other site 691437000771 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 691437000772 nucleotide binding region [chemical binding]; other site 691437000773 ATP-binding site [chemical binding]; other site 691437000774 Rhomboid family; Region: Rhomboid; pfam01694 691437000775 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 691437000776 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 691437000777 alanine racemase; Reviewed; Region: alr; PRK00053 691437000778 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 691437000779 active site 691437000780 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 691437000781 dimer interface [polypeptide binding]; other site 691437000782 substrate binding site [chemical binding]; other site 691437000783 catalytic residues [active] 691437000784 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 691437000785 PemK-like protein; Region: PemK; pfam02452 691437000786 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 691437000787 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 691437000788 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 691437000789 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 691437000790 RNA binding site [nucleotide binding]; other site 691437000791 SprT homologues; Region: SprT; cl01182 691437000792 hypothetical protein; Provisional; Region: PRK04351 691437000793 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 691437000794 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 691437000795 Glycoprotease family; Region: Peptidase_M22; pfam00814 691437000796 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 691437000797 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 691437000798 Coenzyme A binding pocket [chemical binding]; other site 691437000799 UGMP family protein; Validated; Region: PRK09604 691437000800 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 691437000801 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 691437000802 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 691437000803 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 691437000804 ABC transporter; Region: ABC_tran_2; pfam12848 691437000805 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 691437000806 ABC transporter; Region: ABC_tran_2; pfam12848 691437000807 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 691437000808 trimer interface [polypeptide binding]; other site 691437000809 dimer interface [polypeptide binding]; other site 691437000810 putative active site [active] 691437000811 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 691437000812 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 691437000813 CoA binding domain; Region: CoA_binding; pfam02629 691437000814 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 691437000815 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 691437000816 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 691437000817 CAAX protease self-immunity; Region: Abi; pfam02517 691437000818 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 691437000819 oligomerisation interface [polypeptide binding]; other site 691437000820 mobile loop; other site 691437000821 roof hairpin; other site 691437000822 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 691437000823 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 691437000824 ring oligomerisation interface [polypeptide binding]; other site 691437000825 ATP/Mg binding site [chemical binding]; other site 691437000826 stacking interactions; other site 691437000827 hinge regions; other site 691437000828 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 691437000829 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 691437000830 Int/Topo IB signature motif; other site 691437000831 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 691437000832 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 691437000833 non-specific DNA binding site [nucleotide binding]; other site 691437000834 salt bridge; other site 691437000835 sequence-specific DNA binding site [nucleotide binding]; other site 691437000836 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 691437000837 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 691437000838 non-specific DNA binding site [nucleotide binding]; other site 691437000839 salt bridge; other site 691437000840 sequence-specific DNA binding site [nucleotide binding]; other site 691437000841 BRO family, N-terminal domain; Region: Bro-N; smart01040 691437000842 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 691437000843 Helix-turn-helix domain; Region: HTH_17; cl17695 691437000844 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 691437000845 ERF superfamily; Region: ERF; pfam04404 691437000846 Helix-turn-helix domain; Region: HTH_36; pfam13730 691437000847 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 691437000848 Loader and inhibitor of phage G40P; Region: Inhibitor_G39P; pfam11417 691437000849 replicative DNA helicase; Region: DnaB; TIGR00665 691437000850 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 691437000851 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 691437000852 Walker A motif; other site 691437000853 ATP binding site [chemical binding]; other site 691437000854 Walker B motif; other site 691437000855 DNA binding loops [nucleotide binding] 691437000856 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 691437000857 active site 691437000858 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 691437000859 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 691437000860 dimer interface [polypeptide binding]; other site 691437000861 ssDNA binding site [nucleotide binding]; other site 691437000862 tetramer (dimer of dimers) interface [polypeptide binding]; other site 691437000863 dUTPase; Region: dUTPase_2; pfam08761 691437000864 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 691437000865 active site 691437000866 homodimer interface [polypeptide binding]; other site 691437000867 metal binding site [ion binding]; metal-binding site 691437000868 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 691437000869 thymidylate synthase; Reviewed; Region: thyA; PRK01827 691437000870 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 691437000871 dimerization interface [polypeptide binding]; other site 691437000872 active site 691437000873 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 691437000874 Homeodomain-like domain; Region: HTH_23; cl17451 691437000875 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 691437000876 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 691437000877 Terminase-like family; Region: Terminase_6; pfam03237 691437000878 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 691437000879 Phage-related protein [Function unknown]; Region: COG4695; cl01923 691437000880 Phage portal protein; Region: Phage_portal; pfam04860 691437000881 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 691437000882 Phage capsid family; Region: Phage_capsid; pfam05065 691437000883 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 691437000884 Phage-related protein [Function unknown]; Region: COG5412 691437000885 membrane protein P6; Region: PHA01399 691437000886 membrane protein P6; Region: PHA01399 691437000887 Phage-related protein [Function unknown]; Region: COG4722 691437000888 Phage tail protein; Region: Sipho_tail; pfam05709 691437000889 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 691437000890 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 691437000891 active site 691437000892 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 691437000893 Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649 691437000894 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 691437000895 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 691437000896 active site 691437000897 metal binding site [ion binding]; metal-binding site 691437000898 Sporulation related domain; Region: SPOR; pfam05036 691437000899 fumarate hydratase; Reviewed; Region: fumC; PRK00485 691437000900 Class II fumarases; Region: Fumarase_classII; cd01362 691437000901 active site 691437000902 tetramer interface [polypeptide binding]; other site 691437000903 MoxR-like ATPases [General function prediction only]; Region: COG0714 691437000904 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437000905 Walker A motif; other site 691437000906 ATP binding site [chemical binding]; other site 691437000907 Walker B motif; other site 691437000908 arginine finger; other site 691437000909 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 691437000910 Protein of unknown function DUF58; Region: DUF58; pfam01882 691437000911 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 691437000912 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 691437000913 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 691437000914 GMP synthase; Reviewed; Region: guaA; PRK00074 691437000915 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 691437000916 AMP/PPi binding site [chemical binding]; other site 691437000917 candidate oxyanion hole; other site 691437000918 catalytic triad [active] 691437000919 potential glutamine specificity residues [chemical binding]; other site 691437000920 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 691437000921 ATP Binding subdomain [chemical binding]; other site 691437000922 Ligand Binding sites [chemical binding]; other site 691437000923 Dimerization subdomain; other site 691437000924 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 691437000925 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 691437000926 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK05842 691437000927 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 691437000928 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 691437000929 putative dimer interface [polypeptide binding]; other site 691437000930 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 691437000931 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 691437000932 ATP-grasp domain; Region: ATP-grasp; pfam02222 691437000933 adenylosuccinate lyase; Provisional; Region: PRK07492 691437000934 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 691437000935 tetramer interface [polypeptide binding]; other site 691437000936 active site 691437000937 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 691437000938 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 691437000939 ATP binding site [chemical binding]; other site 691437000940 active site 691437000941 substrate binding site [chemical binding]; other site 691437000942 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 691437000943 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 691437000944 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 691437000945 putative active site [active] 691437000946 catalytic triad [active] 691437000947 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 691437000948 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 691437000949 dimerization interface [polypeptide binding]; other site 691437000950 ATP binding site [chemical binding]; other site 691437000951 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 691437000952 dimerization interface [polypeptide binding]; other site 691437000953 ATP binding site [chemical binding]; other site 691437000954 amidophosphoribosyltransferase; Provisional; Region: PRK07631 691437000955 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 691437000956 active site 691437000957 tetramer interface [polypeptide binding]; other site 691437000958 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 691437000959 active site 691437000960 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 691437000961 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 691437000962 dimerization interface [polypeptide binding]; other site 691437000963 putative ATP binding site [chemical binding]; other site 691437000964 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 691437000965 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 691437000966 active site 691437000967 substrate binding site [chemical binding]; other site 691437000968 cosubstrate binding site; other site 691437000969 catalytic site [active] 691437000970 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 691437000971 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 691437000972 purine monophosphate binding site [chemical binding]; other site 691437000973 dimer interface [polypeptide binding]; other site 691437000974 putative catalytic residues [active] 691437000975 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 691437000976 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 691437000977 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 691437000978 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 691437000979 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 691437000980 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 691437000981 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 691437000982 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 691437000983 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 691437000984 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 691437000985 active site 691437000986 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 691437000987 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 691437000988 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 691437000989 PcrB family; Region: PcrB; pfam01884 691437000990 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 691437000991 substrate binding site [chemical binding]; other site 691437000992 putative active site [active] 691437000993 dimer interface [polypeptide binding]; other site 691437000994 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 691437000995 Part of AAA domain; Region: AAA_19; pfam13245 691437000996 AAA domain; Region: AAA_12; pfam13087 691437000997 Family description; Region: UvrD_C_2; pfam13538 691437000998 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 691437000999 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 691437001000 nucleotide binding pocket [chemical binding]; other site 691437001001 K-X-D-G motif; other site 691437001002 catalytic site [active] 691437001003 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 691437001004 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 691437001005 Helix-hairpin-helix motif; Region: HHH; pfam00633 691437001006 helix-hairpin-helix signature motif; other site 691437001007 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 691437001008 Dimer interface [polypeptide binding]; other site 691437001009 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 691437001010 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 691437001011 putative dimer interface [polypeptide binding]; other site 691437001012 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 691437001013 putative dimer interface [polypeptide binding]; other site 691437001014 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 691437001015 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 691437001016 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 691437001017 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 691437001018 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 691437001019 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 691437001020 putative active site [active] 691437001021 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 691437001022 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 691437001023 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 691437001024 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 691437001025 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 691437001026 GatB domain; Region: GatB_Yqey; pfam02637 691437001027 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08248 691437001028 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 691437001029 homodimer interface [polypeptide binding]; other site 691437001030 substrate-cofactor binding pocket; other site 691437001031 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437001032 catalytic residue [active] 691437001033 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 691437001034 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 691437001035 Walker A/P-loop; other site 691437001036 ATP binding site [chemical binding]; other site 691437001037 Q-loop/lid; other site 691437001038 ABC transporter signature motif; other site 691437001039 Walker B; other site 691437001040 D-loop; other site 691437001041 H-loop/switch region; other site 691437001042 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 691437001043 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437001044 active site 691437001045 phosphorylation site [posttranslational modification] 691437001046 intermolecular recognition site; other site 691437001047 dimerization interface [polypeptide binding]; other site 691437001048 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 691437001049 DNA binding site [nucleotide binding] 691437001050 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 691437001051 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 691437001052 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437001053 dimer interface [polypeptide binding]; other site 691437001054 phosphorylation site [posttranslational modification] 691437001055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437001056 ATP binding site [chemical binding]; other site 691437001057 Mg2+ binding site [ion binding]; other site 691437001058 G-X-G motif; other site 691437001059 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 691437001060 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 691437001061 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 691437001062 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 691437001063 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 691437001064 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 691437001065 Walker A/P-loop; other site 691437001066 ATP binding site [chemical binding]; other site 691437001067 Q-loop/lid; other site 691437001068 ABC transporter signature motif; other site 691437001069 Walker B; other site 691437001070 D-loop; other site 691437001071 H-loop/switch region; other site 691437001072 Trans-Isoprenyl Diphosphate Synthases; Region: Trans_IPPS; cd00867 691437001073 substrate binding pocket [chemical binding]; other site 691437001074 substrate-Mg2+ binding site; other site 691437001075 aspartate-rich region 1; other site 691437001076 aspartate-rich region 2; other site 691437001077 Bacillus competence pheromone ComX; Region: ComX; pfam05952 691437001078 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 691437001079 protein binding site [polypeptide binding]; other site 691437001080 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 691437001081 Histidine kinase; Region: HisKA_3; pfam07730 691437001082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437001083 ATP binding site [chemical binding]; other site 691437001084 Mg2+ binding site [ion binding]; other site 691437001085 G-X-G motif; other site 691437001086 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 691437001087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437001088 active site 691437001089 phosphorylation site [posttranslational modification] 691437001090 intermolecular recognition site; other site 691437001091 dimerization interface [polypeptide binding]; other site 691437001092 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 691437001093 dimerization interface [polypeptide binding]; other site 691437001094 DNA binding residues [nucleotide binding] 691437001095 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 691437001096 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 691437001097 FtsX-like permease family; Region: FtsX; pfam02687 691437001098 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 691437001099 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 691437001100 Walker A/P-loop; other site 691437001101 ATP binding site [chemical binding]; other site 691437001102 Q-loop/lid; other site 691437001103 ABC transporter signature motif; other site 691437001104 Walker B; other site 691437001105 D-loop; other site 691437001106 H-loop/switch region; other site 691437001107 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 691437001108 HlyD family secretion protein; Region: HlyD_3; pfam13437 691437001109 putative membrane fusion protein; Region: TIGR02828 691437001110 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 691437001111 active site 691437001112 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 691437001113 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 691437001114 ATP binding site [chemical binding]; other site 691437001115 substrate interface [chemical binding]; other site 691437001116 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 691437001117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437001118 dimer interface [polypeptide binding]; other site 691437001119 conserved gate region; other site 691437001120 putative PBP binding loops; other site 691437001121 ABC-ATPase subunit interface; other site 691437001122 Transposase [DNA replication, recombination, and repair]; Region: COG5421 691437001123 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 691437001124 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 691437001125 TIGR02677 family protein; Region: TIGR02677 691437001126 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 691437001127 TIGR02678 family protein; Region: TIGR02678 691437001128 TIGR02680 family protein; Region: TIGR02680 691437001129 P-loop containing region of AAA domain; Region: AAA_29; cl17516 691437001130 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 691437001131 TIGR02679 family protein; Region: TIGR02679 691437001132 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 691437001133 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 691437001134 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 691437001135 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 691437001136 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 691437001137 homodimer interface [polypeptide binding]; other site 691437001138 homotetramer interface [polypeptide binding]; other site 691437001139 active site pocket [active] 691437001140 cleavage site 691437001141 drug efflux system protein MdtG; Provisional; Region: PRK09874 691437001142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437001143 putative substrate translocation pore; other site 691437001144 phage shock protein A; Region: phageshock_pspA; TIGR02977 691437001145 CobD/Cbib protein; Region: CobD_Cbib; cl00561 691437001146 Predicted membrane protein [Function unknown]; Region: COG1511 691437001147 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 691437001148 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 691437001149 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 691437001150 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 691437001151 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 691437001152 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437001153 dimer interface [polypeptide binding]; other site 691437001154 phosphorylation site [posttranslational modification] 691437001155 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437001156 ATP binding site [chemical binding]; other site 691437001157 Mg2+ binding site [ion binding]; other site 691437001158 G-X-G motif; other site 691437001159 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 691437001160 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437001161 active site 691437001162 phosphorylation site [posttranslational modification] 691437001163 intermolecular recognition site; other site 691437001164 dimerization interface [polypeptide binding]; other site 691437001165 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 691437001166 DNA binding site [nucleotide binding] 691437001167 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 691437001168 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 691437001169 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 691437001170 protein binding site [polypeptide binding]; other site 691437001171 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 691437001172 Protein of unknown function (DUF962); Region: DUF962; pfam06127 691437001173 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 691437001174 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 691437001175 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 691437001176 putative lipid kinase; Reviewed; Region: PRK13337 691437001177 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 691437001178 TRAM domain; Region: TRAM; pfam01938 691437001179 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 691437001180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437001181 S-adenosylmethionine binding site [chemical binding]; other site 691437001182 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 691437001183 HsdM N-terminal domain; Region: HsdM_N; pfam12161 691437001184 Methyltransferase domain; Region: Methyltransf_26; pfam13659 691437001185 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 691437001186 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 691437001187 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 691437001188 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 691437001189 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 691437001190 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 691437001191 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 691437001192 ATP binding site [chemical binding]; other site 691437001193 putative Mg++ binding site [ion binding]; other site 691437001194 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 691437001195 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 691437001196 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 691437001197 dimerization interface [polypeptide binding]; other site 691437001198 putative DNA binding site [nucleotide binding]; other site 691437001199 putative Zn2+ binding site [ion binding]; other site 691437001200 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 691437001201 putative hydrophobic ligand binding site [chemical binding]; other site 691437001202 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 691437001203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437001204 S-adenosylmethionine binding site [chemical binding]; other site 691437001205 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 691437001206 SpoOM protein; Region: Spo0M; pfam07070 691437001207 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 691437001208 active site 691437001209 8-oxo-dGMP binding site [chemical binding]; other site 691437001210 nudix motif; other site 691437001211 metal binding site [ion binding]; metal-binding site 691437001212 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 691437001213 LabA_like proteins; Region: LabA_like; cd06167 691437001214 putative metal binding site [ion binding]; other site 691437001215 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 691437001216 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 691437001217 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 691437001218 active site 691437001219 Substrate binding site; other site 691437001220 Mg++ binding site; other site 691437001221 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 691437001222 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 691437001223 putative trimer interface [polypeptide binding]; other site 691437001224 putative CoA binding site [chemical binding]; other site 691437001225 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 691437001226 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 691437001227 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 691437001228 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 691437001229 active site 691437001230 substrate binding site [chemical binding]; other site 691437001231 metal binding site [ion binding]; metal-binding site 691437001232 Sensory domain found in PocR; Region: PocR; pfam10114 691437001233 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 691437001234 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 691437001235 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 691437001236 DNA binding residues [nucleotide binding] 691437001237 dimerization interface [polypeptide binding]; other site 691437001238 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 691437001239 anti sigma factor interaction site; other site 691437001240 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 691437001241 regulatory phosphorylation site [posttranslational modification]; other site 691437001242 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 691437001243 PAS fold; Region: PAS_3; pfam08447 691437001244 putative active site [active] 691437001245 heme pocket [chemical binding]; other site 691437001246 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 691437001247 PAS domain; Region: PAS_9; pfam13426 691437001248 putative active site [active] 691437001249 heme pocket [chemical binding]; other site 691437001250 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 691437001251 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 691437001252 RDD family; Region: RDD; pfam06271 691437001253 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 691437001254 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 691437001255 dimer interface [polypeptide binding]; other site 691437001256 active site 691437001257 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 691437001258 catalytic residues [active] 691437001259 substrate binding site [chemical binding]; other site 691437001260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437001261 putative substrate translocation pore; other site 691437001262 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 691437001263 IucA / IucC family; Region: IucA_IucC; pfam04183 691437001264 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 691437001265 IucA / IucC family; Region: IucA_IucC; pfam04183 691437001266 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 691437001267 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 691437001268 dimerization interface [polypeptide binding]; other site 691437001269 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 691437001270 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 691437001271 dimer interface [polypeptide binding]; other site 691437001272 putative CheW interface [polypeptide binding]; other site 691437001273 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 691437001274 ThiC-associated domain; Region: ThiC-associated; pfam13667 691437001275 ThiC family; Region: ThiC; pfam01964 691437001276 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 691437001277 Probable transposase; Region: OrfB_IS605; pfam01385 691437001278 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 691437001279 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 691437001280 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 691437001281 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437001282 homodimer interface [polypeptide binding]; other site 691437001283 catalytic residue [active] 691437001284 thiamine pyrophosphate protein; Validated; Region: PRK08199 691437001285 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 691437001286 PYR/PP interface [polypeptide binding]; other site 691437001287 dimer interface [polypeptide binding]; other site 691437001288 TPP binding site [chemical binding]; other site 691437001289 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 691437001290 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 691437001291 TPP-binding site [chemical binding]; other site 691437001292 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 691437001293 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 691437001294 NAD(P) binding site [chemical binding]; other site 691437001295 catalytic residues [active] 691437001296 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437001297 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 691437001298 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437001299 Major Facilitator Superfamily; Region: MFS_1; pfam07690 691437001300 putative substrate translocation pore; other site 691437001301 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 691437001302 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 691437001303 DNA binding residues [nucleotide binding] 691437001304 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 691437001305 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 691437001306 catalytic loop [active] 691437001307 iron binding site [ion binding]; other site 691437001308 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 691437001309 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 691437001310 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 691437001311 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 691437001312 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 691437001313 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 691437001314 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 691437001315 Ligand binding site; other site 691437001316 metal-binding site 691437001317 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 691437001318 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 691437001319 XdhC Rossmann domain; Region: XdhC_C; pfam13478 691437001320 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 691437001321 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 691437001322 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 691437001323 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 691437001324 hexamer interface [polypeptide binding]; other site 691437001325 RNA binding site [nucleotide binding]; other site 691437001326 Histidine-zinc binding site [chemical binding]; other site 691437001327 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 691437001328 active sites [active] 691437001329 tetramer interface [polypeptide binding]; other site 691437001330 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 691437001331 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 691437001332 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 691437001333 NAD binding site [chemical binding]; other site 691437001334 ligand binding site [chemical binding]; other site 691437001335 catalytic site [active] 691437001336 Class I aldolases; Region: Aldolase_Class_I; cl17187 691437001337 Putative amidase domain; Region: Amidase_6; pfam12671 691437001338 Uncharacterized conserved protein [Function unknown]; Region: COG1556 691437001339 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 691437001340 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 691437001341 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 691437001342 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 691437001343 Cysteine-rich domain; Region: CCG; pfam02754 691437001344 Cysteine-rich domain; Region: CCG; pfam02754 691437001345 Transcriptional regulators [Transcription]; Region: FadR; COG2186 691437001346 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 691437001347 DNA-binding site [nucleotide binding]; DNA binding site 691437001348 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 691437001349 L-lactate permease; Region: Lactate_perm; cl00701 691437001350 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 691437001351 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 691437001352 NlpC/P60 family; Region: NLPC_P60; pfam00877 691437001353 PAS domain S-box; Region: sensory_box; TIGR00229 691437001354 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 691437001355 putative active site [active] 691437001356 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 691437001357 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 691437001358 metal binding site [ion binding]; metal-binding site 691437001359 active site 691437001360 I-site; other site 691437001361 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 691437001362 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 691437001363 The Phox Homology domain, a phosphoinositide binding module; Region: PX_domain; cl02563 691437001364 phosphoinositide binding site [chemical binding]; other site 691437001365 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 691437001366 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 691437001367 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 691437001368 substrate binding pocket [chemical binding]; other site 691437001369 catalytic triad [active] 691437001370 Preprotein translocase SecG subunit; Region: SecG; pfam03840 691437001371 Esterase/lipase [General function prediction only]; Region: COG1647 691437001372 ribonuclease R; Region: RNase_R; TIGR02063 691437001373 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 691437001374 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 691437001375 RNB domain; Region: RNB; pfam00773 691437001376 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 691437001377 RNA binding site [nucleotide binding]; other site 691437001378 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 691437001379 SmpB-tmRNA interface; other site 691437001380 Staygreen protein; Region: Staygreen; pfam12638 691437001381 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 691437001382 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 691437001383 DNA binding residues [nucleotide binding] 691437001384 dimerization interface [polypeptide binding]; other site 691437001385 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 691437001386 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 691437001387 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 691437001388 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 691437001389 dimanganese center [ion binding]; other site 691437001390 Transcriptional regulator [Transcription]; Region: LysR; COG0583 691437001391 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 691437001392 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 691437001393 dimerization interface [polypeptide binding]; other site 691437001394 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 691437001395 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 691437001396 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 691437001397 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 691437001398 tetramer interface [polypeptide binding]; other site 691437001399 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 691437001400 tetramer interface [polypeptide binding]; other site 691437001401 active site 691437001402 metal binding site [ion binding]; metal-binding site 691437001403 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 691437001404 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 691437001405 dimer interface [polypeptide binding]; other site 691437001406 active site 691437001407 catalytic residue [active] 691437001408 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 691437001409 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 691437001410 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 691437001411 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 691437001412 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 691437001413 putative substrate binding pocket [chemical binding]; other site 691437001414 trimer interface [polypeptide binding]; other site 691437001415 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 691437001416 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 691437001417 NAD binding site [chemical binding]; other site 691437001418 catalytic residues [active] 691437001419 Transcriptional regulators [Transcription]; Region: FadR; COG2186 691437001420 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 691437001421 DNA-binding site [nucleotide binding]; DNA binding site 691437001422 FCD domain; Region: FCD; pfam07729 691437001423 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 691437001424 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 691437001425 putative ligand binding site [chemical binding]; other site 691437001426 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 691437001427 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 691437001428 TM-ABC transporter signature motif; other site 691437001429 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 691437001430 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 691437001431 TM-ABC transporter signature motif; other site 691437001432 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 691437001433 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 691437001434 Walker A/P-loop; other site 691437001435 ATP binding site [chemical binding]; other site 691437001436 Q-loop/lid; other site 691437001437 ABC transporter signature motif; other site 691437001438 Walker B; other site 691437001439 D-loop; other site 691437001440 H-loop/switch region; other site 691437001441 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 691437001442 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 691437001443 Walker A/P-loop; other site 691437001444 ATP binding site [chemical binding]; other site 691437001445 Q-loop/lid; other site 691437001446 ABC transporter signature motif; other site 691437001447 Walker B; other site 691437001448 D-loop; other site 691437001449 H-loop/switch region; other site 691437001450 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 691437001451 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 691437001452 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 691437001453 pyruvate kinase; Provisional; Region: PRK14725 691437001454 active site 691437001455 BioY family; Region: BioY; pfam02632 691437001456 AAA domain; Region: AAA_26; pfam13500 691437001457 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 691437001458 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 691437001459 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 691437001460 inhibitor-cofactor binding pocket; inhibition site 691437001461 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437001462 catalytic residue [active] 691437001463 Coat F domain; Region: Coat_F; pfam07875 691437001464 Proline dehydrogenase; Region: Pro_dh; cl03282 691437001465 YuzL-like protein; Region: YuzL; pfam14115 691437001466 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 691437001467 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 691437001468 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 691437001469 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 691437001470 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 691437001471 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 691437001472 substrate binding site [chemical binding]; other site 691437001473 oxyanion hole (OAH) forming residues; other site 691437001474 trimer interface [polypeptide binding]; other site 691437001475 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 691437001476 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 691437001477 dimer interface [polypeptide binding]; other site 691437001478 active site 691437001479 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 691437001480 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 691437001481 active site 691437001482 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 691437001483 ArsC family; Region: ArsC; pfam03960 691437001484 putative ArsC-like catalytic residues; other site 691437001485 putative TRX-like catalytic residues [active] 691437001486 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 691437001487 lipoyl attachment site [posttranslational modification]; other site 691437001488 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 691437001489 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 691437001490 putative active site [active] 691437001491 putative metal binding site [ion binding]; other site 691437001492 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 691437001493 catalytic residues [active] 691437001494 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 691437001495 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 691437001496 Walker A/P-loop; other site 691437001497 ATP binding site [chemical binding]; other site 691437001498 Q-loop/lid; other site 691437001499 ABC transporter signature motif; other site 691437001500 Walker B; other site 691437001501 D-loop; other site 691437001502 H-loop/switch region; other site 691437001503 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 691437001504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437001505 dimer interface [polypeptide binding]; other site 691437001506 conserved gate region; other site 691437001507 ABC-ATPase subunit interface; other site 691437001508 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 691437001509 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 691437001510 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 691437001511 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 691437001512 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 691437001513 Walker A/P-loop; other site 691437001514 ATP binding site [chemical binding]; other site 691437001515 Q-loop/lid; other site 691437001516 ABC transporter signature motif; other site 691437001517 Walker B; other site 691437001518 D-loop; other site 691437001519 H-loop/switch region; other site 691437001520 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 691437001521 FeS assembly protein SufD; Region: sufD; TIGR01981 691437001522 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 691437001523 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 691437001524 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 691437001525 catalytic residue [active] 691437001526 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 691437001527 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 691437001528 trimerization site [polypeptide binding]; other site 691437001529 active site 691437001530 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 691437001531 FeS assembly protein SufB; Region: sufB; TIGR01980 691437001532 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 691437001533 Uncharacterized conserved protein [Function unknown]; Region: COG1801 691437001534 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 691437001535 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 691437001536 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 691437001537 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 691437001538 active site 691437001539 metal binding site [ion binding]; metal-binding site 691437001540 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 691437001541 Uncharacterized conserved protein [Function unknown]; Region: COG3377 691437001542 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 691437001543 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 691437001544 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 691437001545 putative ligand binding site [chemical binding]; other site 691437001546 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 691437001547 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 691437001548 TM-ABC transporter signature motif; other site 691437001549 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 691437001550 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 691437001551 TM-ABC transporter signature motif; other site 691437001552 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 691437001553 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 691437001554 Walker A/P-loop; other site 691437001555 ATP binding site [chemical binding]; other site 691437001556 Q-loop/lid; other site 691437001557 ABC transporter signature motif; other site 691437001558 Walker B; other site 691437001559 D-loop; other site 691437001560 H-loop/switch region; other site 691437001561 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 691437001562 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 691437001563 Walker A/P-loop; other site 691437001564 ATP binding site [chemical binding]; other site 691437001565 Q-loop/lid; other site 691437001566 ABC transporter signature motif; other site 691437001567 Walker B; other site 691437001568 D-loop; other site 691437001569 H-loop/switch region; other site 691437001570 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 691437001571 Peptidase family M23; Region: Peptidase_M23; pfam01551 691437001572 lipoyl synthase; Provisional; Region: PRK05481 691437001573 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 691437001574 FeS/SAM binding site; other site 691437001575 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 691437001576 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 691437001577 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 691437001578 Uncharacterized conserved protein [Function unknown]; Region: COG2445 691437001579 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 691437001580 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 691437001581 active site 691437001582 motif I; other site 691437001583 motif II; other site 691437001584 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 691437001585 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 691437001586 tetramer interfaces [polypeptide binding]; other site 691437001587 binuclear metal-binding site [ion binding]; other site 691437001588 spore coat protein YutH; Region: spore_yutH; TIGR02905 691437001589 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 691437001590 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 691437001591 dimerization interface [polypeptide binding]; other site 691437001592 ligand binding site [chemical binding]; other site 691437001593 NADP binding site [chemical binding]; other site 691437001594 catalytic site [active] 691437001595 homoserine dehydrogenase; Provisional; Region: PRK06349 691437001596 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 691437001597 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 691437001598 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 691437001599 threonine synthase; Reviewed; Region: PRK06721 691437001600 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 691437001601 homodimer interface [polypeptide binding]; other site 691437001602 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437001603 catalytic residue [active] 691437001604 homoserine kinase; Provisional; Region: PRK01212 691437001605 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 691437001606 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 691437001607 NifU-like domain; Region: NifU; pfam01106 691437001608 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 691437001609 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 691437001610 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 691437001611 hypothetical protein; Provisional; Region: PRK13669 691437001612 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 691437001613 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 691437001614 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 691437001615 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 691437001616 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 691437001617 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 691437001618 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 691437001619 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 691437001620 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 691437001621 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 691437001622 nudix motif; other site 691437001623 chaperone protein DnaJ; Provisional; Region: PRK14279 691437001624 Putative membrane protein; Region: YuiB; pfam14068 691437001625 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 691437001626 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 691437001627 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 691437001628 cobalamin binding residues [chemical binding]; other site 691437001629 putative BtuC binding residues; other site 691437001630 dimer interface [polypeptide binding]; other site 691437001631 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 691437001632 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 691437001633 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 691437001634 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 691437001635 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 691437001636 transmembrane helices; other site 691437001637 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 691437001638 active site 691437001639 catalytic site [active] 691437001640 substrate binding site [chemical binding]; other site 691437001641 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 691437001642 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 691437001643 E-class dimer interface [polypeptide binding]; other site 691437001644 P-class dimer interface [polypeptide binding]; other site 691437001645 active site 691437001646 Cu2+ binding site [ion binding]; other site 691437001647 Zn2+ binding site [ion binding]; other site 691437001648 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 691437001649 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 691437001650 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437001651 homodimer interface [polypeptide binding]; other site 691437001652 catalytic residue [active] 691437001653 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 691437001654 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 691437001655 AsnC family; Region: AsnC_trans_reg; pfam01037 691437001656 hypothetical protein; Validated; Region: PRK07682 691437001657 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 691437001658 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437001659 homodimer interface [polypeptide binding]; other site 691437001660 catalytic residue [active] 691437001661 general stress protein 13; Validated; Region: PRK08059 691437001662 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 691437001663 RNA binding site [nucleotide binding]; other site 691437001664 Domain of unknown function (DUF378); Region: DUF378; pfam04070 691437001665 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 691437001666 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 691437001667 dimer interface [polypeptide binding]; other site 691437001668 active site 691437001669 metal binding site [ion binding]; metal-binding site 691437001670 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 691437001671 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 691437001672 active site 691437001673 dimer interface [polypeptide binding]; other site 691437001674 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 691437001675 dimer interface [polypeptide binding]; other site 691437001676 active site 691437001677 YugN-like family; Region: YugN; pfam08868 691437001678 Ion channel; Region: Ion_trans_2; pfam07885 691437001679 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 691437001680 TrkA-N domain; Region: TrkA_N; pfam02254 691437001681 Small acid-soluble spore protein H family; Region: SspH; pfam08141 691437001682 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 691437001683 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 691437001684 Coenzyme A binding pocket [chemical binding]; other site 691437001685 Staphylococcal nuclease homologues; Region: SNc; smart00318 691437001686 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 691437001687 Catalytic site; other site 691437001688 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 691437001689 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 691437001690 MgtC family; Region: MgtC; pfam02308 691437001691 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 691437001692 EamA-like transporter family; Region: EamA; pfam00892 691437001693 transglutaminase; Provisional; Region: tgl; PRK03187 691437001694 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 691437001695 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 691437001696 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 691437001697 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 691437001698 siderophore binding site; other site 691437001699 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 691437001700 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 691437001701 ABC-ATPase subunit interface; other site 691437001702 dimer interface [polypeptide binding]; other site 691437001703 putative PBP binding regions; other site 691437001704 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 691437001705 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 691437001706 ABC-ATPase subunit interface; other site 691437001707 dimer interface [polypeptide binding]; other site 691437001708 putative PBP binding regions; other site 691437001709 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 691437001710 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 691437001711 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 691437001712 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 691437001713 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 691437001714 ligand binding site; other site 691437001715 oligomer interface; other site 691437001716 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 691437001717 dimer interface [polypeptide binding]; other site 691437001718 N-terminal domain interface [polypeptide binding]; other site 691437001719 sulfate 1 binding site; other site 691437001720 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 691437001721 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 691437001722 ligand binding site; other site 691437001723 oligomer interface; other site 691437001724 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 691437001725 dimer interface [polypeptide binding]; other site 691437001726 N-terminal domain interface [polypeptide binding]; other site 691437001727 sulfate 1 binding site; other site 691437001728 glycogen synthase; Provisional; Region: glgA; PRK00654 691437001729 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 691437001730 ADP-binding pocket [chemical binding]; other site 691437001731 homodimer interface [polypeptide binding]; other site 691437001732 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 691437001733 homodimer interface [polypeptide binding]; other site 691437001734 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 691437001735 active site pocket [active] 691437001736 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 691437001737 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 691437001738 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 691437001739 UbiA prenyltransferase family; Region: UbiA; pfam01040 691437001740 salicylate biosynthesis isochorismate synthase; Validated; Region: PRK07054 691437001741 chorismate binding enzyme; Region: Chorismate_bind; cl10555 691437001742 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 691437001743 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 691437001744 dimer interface [polypeptide binding]; other site 691437001745 tetramer interface [polypeptide binding]; other site 691437001746 PYR/PP interface [polypeptide binding]; other site 691437001747 TPP binding site [chemical binding]; other site 691437001748 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 691437001749 TPP-binding site; other site 691437001750 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 691437001751 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 691437001752 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 691437001753 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 691437001754 substrate binding site [chemical binding]; other site 691437001755 oxyanion hole (OAH) forming residues; other site 691437001756 trimer interface [polypeptide binding]; other site 691437001757 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 691437001758 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 691437001759 acyl-activating enzyme (AAE) consensus motif; other site 691437001760 putative AMP binding site [chemical binding]; other site 691437001761 putative active site [active] 691437001762 putative CoA binding site [chemical binding]; other site 691437001763 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 691437001764 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 691437001765 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 691437001766 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 691437001767 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 691437001768 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 691437001769 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 691437001770 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 691437001771 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 691437001772 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 691437001773 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 691437001774 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 691437001775 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 691437001776 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 691437001777 metal binding site [ion binding]; metal-binding site 691437001778 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 691437001779 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 691437001780 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 691437001781 Haemolytic domain; Region: Haemolytic; pfam01809 691437001782 S-ribosylhomocysteinase; Provisional; Region: PRK02260 691437001783 Tumour necrosis factor receptor superfamily member 19; Region: RELT; pfam12606 691437001784 Ferritin-like domain; Region: Ferritin; pfam00210 691437001785 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 691437001786 dimerization interface [polypeptide binding]; other site 691437001787 DPS ferroxidase diiron center [ion binding]; other site 691437001788 ion pore; other site 691437001789 Holin family; Region: Phage_holin_4; pfam05105 691437001790 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 691437001791 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 691437001792 nudix motif; other site 691437001793 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 691437001794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437001795 dimer interface [polypeptide binding]; other site 691437001796 conserved gate region; other site 691437001797 putative PBP binding loops; other site 691437001798 ABC-ATPase subunit interface; other site 691437001799 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 691437001800 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 691437001801 Walker A/P-loop; other site 691437001802 ATP binding site [chemical binding]; other site 691437001803 Q-loop/lid; other site 691437001804 ABC transporter signature motif; other site 691437001805 Walker B; other site 691437001806 D-loop; other site 691437001807 H-loop/switch region; other site 691437001808 NMT1-like family; Region: NMT1_2; pfam13379 691437001809 NMT1/THI5 like; Region: NMT1; pfam09084 691437001810 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 691437001811 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 691437001812 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 691437001813 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 691437001814 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 691437001815 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437001816 putative substrate translocation pore; other site 691437001817 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 691437001818 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 691437001819 active site 691437001820 substrate-binding site [chemical binding]; other site 691437001821 metal-binding site [ion binding] 691437001822 ATP binding site [chemical binding]; other site 691437001823 S-adenosylmethionine synthetase; Validated; Region: PRK05250 691437001824 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 691437001825 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 691437001826 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 691437001827 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 691437001828 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 691437001829 trimer interface [polypeptide binding]; other site 691437001830 putative metal binding site [ion binding]; other site 691437001831 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 691437001832 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437001833 S-adenosylmethionine binding site [chemical binding]; other site 691437001834 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 691437001835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437001836 Major Facilitator Superfamily; Region: MFS_1; pfam07690 691437001837 putative substrate translocation pore; other site 691437001838 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 691437001839 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 691437001840 HIGH motif; other site 691437001841 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 691437001842 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 691437001843 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 691437001844 active site 691437001845 KMSKS motif; other site 691437001846 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 691437001847 tRNA binding surface [nucleotide binding]; other site 691437001848 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 691437001849 active site residue [active] 691437001850 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 691437001851 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 691437001852 non-specific DNA binding site [nucleotide binding]; other site 691437001853 salt bridge; other site 691437001854 sequence-specific DNA binding site [nucleotide binding]; other site 691437001855 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 691437001856 binding surface 691437001857 TPR motif; other site 691437001858 Tetratricopeptide repeat; Region: TPR_12; pfam13424 691437001859 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 691437001860 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 691437001861 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 691437001862 Thermolysin metallopeptidase, catalytic domain; Region: Peptidase_M4; pfam01447 691437001863 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 691437001864 active site 691437001865 Zn binding site [ion binding]; other site 691437001866 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 691437001867 HI0933-like protein; Region: HI0933_like; pfam03486 691437001868 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 691437001869 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 691437001870 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 691437001871 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 691437001872 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 691437001873 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 691437001874 RNA binding surface [nucleotide binding]; other site 691437001875 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 691437001876 active site 691437001877 uracil binding [chemical binding]; other site 691437001878 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 691437001879 dipeptidase PepV; Reviewed; Region: PRK07318 691437001880 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 691437001881 active site 691437001882 metal binding site [ion binding]; metal-binding site 691437001883 sugar efflux transporter; Region: 2A0120; TIGR00899 691437001884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437001885 putative substrate translocation pore; other site 691437001886 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 691437001887 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 691437001888 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 691437001889 pullulanase, type I; Region: pulA_typeI; TIGR02104 691437001890 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 691437001891 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 691437001892 Ca binding site [ion binding]; other site 691437001893 active site 691437001894 catalytic site [active] 691437001895 Phosphotransferase enzyme family; Region: APH; pfam01636 691437001896 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 691437001897 active site 691437001898 substrate binding site [chemical binding]; other site 691437001899 ATP binding site [chemical binding]; other site 691437001900 YtzH-like protein; Region: YtzH; pfam14165 691437001901 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437001902 S-adenosylmethionine binding site [chemical binding]; other site 691437001903 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 691437001904 Predicted small secreted protein [Function unknown]; Region: COG5584 691437001905 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 691437001906 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 691437001907 oligomer interface [polypeptide binding]; other site 691437001908 active site 691437001909 metal binding site [ion binding]; metal-binding site 691437001910 NTPase; Reviewed; Region: PRK03114 691437001911 hypothetical protein; Provisional; Region: PRK13668 691437001912 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 691437001913 putative tRNA-binding site [nucleotide binding]; other site 691437001914 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 691437001915 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 691437001916 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 691437001917 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 691437001918 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 691437001919 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 691437001920 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 691437001921 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 691437001922 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 691437001923 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 691437001924 Chorismate mutase type II; Region: CM_2; cl00693 691437001925 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 691437001926 catabolite control protein A; Region: ccpA; TIGR01481 691437001927 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 691437001928 DNA binding site [nucleotide binding] 691437001929 domain linker motif; other site 691437001930 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 691437001931 dimerization interface [polypeptide binding]; other site 691437001932 effector binding site; other site 691437001933 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 691437001934 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 691437001935 active site 691437001936 Zn binding site [ion binding]; other site 691437001937 FOG: CBS domain [General function prediction only]; Region: COG0517 691437001938 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 691437001939 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 691437001940 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 691437001941 Coenzyme A binding pocket [chemical binding]; other site 691437001942 acetyl-CoA synthetase; Provisional; Region: PRK04319 691437001943 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 691437001944 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 691437001945 active site 691437001946 acyl-activating enzyme (AAE) consensus motif; other site 691437001947 putative CoA binding site [chemical binding]; other site 691437001948 AMP binding site [chemical binding]; other site 691437001949 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 691437001950 Transglycosylase; Region: Transgly; pfam00912 691437001951 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 691437001952 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 691437001953 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 691437001954 active site 691437001955 HIGH motif; other site 691437001956 dimer interface [polypeptide binding]; other site 691437001957 KMSKS motif; other site 691437001958 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 691437001959 RNA binding surface [nucleotide binding]; other site 691437001960 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 691437001961 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 691437001962 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 691437001963 RNA binding surface [nucleotide binding]; other site 691437001964 GAF domain; Region: GAF_3; pfam13492 691437001965 GAF domain; Region: GAF_2; pfam13185 691437001966 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 691437001967 GAF domain; Region: GAF_3; pfam13492 691437001968 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 691437001969 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 691437001970 metal binding site [ion binding]; metal-binding site 691437001971 active site 691437001972 I-site; other site 691437001973 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 691437001974 GAF domain; Region: GAF_2; pfam13185 691437001975 histidinol-phosphatase; Reviewed; Region: PRK08123 691437001976 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 691437001977 active site 691437001978 dimer interface [polypeptide binding]; other site 691437001979 septation ring formation regulator EzrA; Provisional; Region: PRK04778 691437001980 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 691437001981 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 691437001982 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 691437001983 catalytic residue [active] 691437001984 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 691437001985 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 691437001986 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 691437001987 Ligand Binding Site [chemical binding]; other site 691437001988 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 691437001989 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 691437001990 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 691437001991 active site 691437001992 acyl-activating enzyme (AAE) consensus motif; other site 691437001993 putative CoA binding site [chemical binding]; other site 691437001994 AMP binding site [chemical binding]; other site 691437001995 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 691437001996 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 691437001997 tandem repeat interface [polypeptide binding]; other site 691437001998 oligomer interface [polypeptide binding]; other site 691437001999 active site residues [active] 691437002000 RDD family; Region: RDD; pfam06271 691437002001 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 691437002002 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 691437002003 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 691437002004 dimer interface [polypeptide binding]; other site 691437002005 catalytic triad [active] 691437002006 peroxidatic and resolving cysteines [active] 691437002007 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 691437002008 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437002009 S-adenosylmethionine binding site [chemical binding]; other site 691437002010 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 691437002011 propionate/acetate kinase; Provisional; Region: PRK12379 691437002012 SCP-2 sterol transfer family; Region: SCP2; pfam02036 691437002013 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 691437002014 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 691437002015 acyl-activating enzyme (AAE) consensus motif; other site 691437002016 putative AMP binding site [chemical binding]; other site 691437002017 putative active site [active] 691437002018 putative CoA binding site [chemical binding]; other site 691437002019 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 691437002020 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 691437002021 active site 691437002022 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 691437002023 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 691437002024 active site 691437002025 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 691437002026 enoyl-CoA hydratase; Provisional; Region: PRK06688 691437002027 substrate binding site [chemical binding]; other site 691437002028 oxyanion hole (OAH) forming residues; other site 691437002029 trimer interface [polypeptide binding]; other site 691437002030 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 691437002031 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437002032 NAD(P) binding site [chemical binding]; other site 691437002033 active site 691437002034 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 691437002035 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 691437002036 dimer interface [polypeptide binding]; other site 691437002037 active site 691437002038 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 691437002039 ABC1 family; Region: ABC1; cl17513 691437002040 Transmembrane proteins 14C; Region: Tmemb_14; cl02346 691437002041 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 691437002042 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 691437002043 NAD binding site [chemical binding]; other site 691437002044 catalytic Zn binding site [ion binding]; other site 691437002045 substrate binding site [chemical binding]; other site 691437002046 structural Zn binding site [ion binding]; other site 691437002047 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 691437002048 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 691437002049 NAD(P) binding site [chemical binding]; other site 691437002050 catalytic residues [active] 691437002051 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 691437002052 active site 691437002053 diiron metal binding site [ion binding]; other site 691437002054 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 691437002055 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 691437002056 DNA binding residues [nucleotide binding] 691437002057 dimerization interface [polypeptide binding]; other site 691437002058 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 691437002059 MPT binding site; other site 691437002060 trimer interface [polypeptide binding]; other site 691437002061 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 691437002062 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 691437002063 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 691437002064 catalytic residue [active] 691437002065 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437002066 Major Facilitator Superfamily; Region: MFS_1; pfam07690 691437002067 putative substrate translocation pore; other site 691437002068 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 691437002069 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 691437002070 hypothetical protein; Provisional; Region: PRK07206 691437002071 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 691437002072 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 691437002073 dimerization interface [polypeptide binding]; other site 691437002074 putative DNA binding site [nucleotide binding]; other site 691437002075 putative Zn2+ binding site [ion binding]; other site 691437002076 acetyl-CoA synthetase; Provisional; Region: PRK04319 691437002077 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_2; cd05973 691437002078 active site 691437002079 acyl-activating enzyme (AAE) consensus motif; other site 691437002080 putative CoA binding site [chemical binding]; other site 691437002081 AMP binding site [chemical binding]; other site 691437002082 argininosuccinate synthase; Provisional; Region: PRK13820 691437002083 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 691437002084 ANP binding site [chemical binding]; other site 691437002085 Substrate Binding Site II [chemical binding]; other site 691437002086 Substrate Binding Site I [chemical binding]; other site 691437002087 argininosuccinate lyase; Provisional; Region: PRK00855 691437002088 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 691437002089 active sites [active] 691437002090 tetramer interface [polypeptide binding]; other site 691437002091 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 691437002092 Ligand Binding Site [chemical binding]; other site 691437002093 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 691437002094 classical (c) SDRs; Region: SDR_c; cd05233 691437002095 NAD(P) binding site [chemical binding]; other site 691437002096 active site 691437002097 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 691437002098 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 691437002099 hexamer interface [polypeptide binding]; other site 691437002100 ligand binding site [chemical binding]; other site 691437002101 putative active site [active] 691437002102 NAD(P) binding site [chemical binding]; other site 691437002103 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 691437002104 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 691437002105 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 691437002106 active site 691437002107 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 691437002108 metal-dependent hydrolase; Provisional; Region: PRK00685 691437002109 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 691437002110 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 691437002111 DNA-binding site [nucleotide binding]; DNA binding site 691437002112 DRTGG domain; Region: DRTGG; pfam07085 691437002113 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 691437002114 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 691437002115 active site 2 [active] 691437002116 active site 1 [active] 691437002117 YtpI-like protein; Region: YtpI; pfam14007 691437002118 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 691437002119 DHH family; Region: DHH; pfam01368 691437002120 DHHA1 domain; Region: DHHA1; pfam02272 691437002121 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 691437002122 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 691437002123 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 691437002124 active site 691437002125 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 691437002126 generic binding surface II; other site 691437002127 generic binding surface I; other site 691437002128 Transcriptional regulators [Transcription]; Region: FadR; COG2186 691437002129 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 691437002130 DNA-binding site [nucleotide binding]; DNA binding site 691437002131 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 691437002132 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 691437002133 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 691437002134 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 691437002135 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 691437002136 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 691437002137 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 691437002138 active site 691437002139 ADP/pyrophosphate binding site [chemical binding]; other site 691437002140 dimerization interface [polypeptide binding]; other site 691437002141 allosteric effector site; other site 691437002142 fructose-1,6-bisphosphate binding site; other site 691437002143 pyruvate kinase; Provisional; Region: PRK06354 691437002144 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 691437002145 domain interfaces; other site 691437002146 active site 691437002147 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 691437002148 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 691437002149 Protein of unknown function (DUF441); Region: DUF441; pfam04284 691437002150 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 691437002151 dimer interface [polypeptide binding]; other site 691437002152 Citrate synthase; Region: Citrate_synt; pfam00285 691437002153 active site 691437002154 citrylCoA binding site [chemical binding]; other site 691437002155 oxalacetate/citrate binding site [chemical binding]; other site 691437002156 coenzyme A binding site [chemical binding]; other site 691437002157 catalytic triad [active] 691437002158 isocitrate dehydrogenase; Reviewed; Region: PRK07006 691437002159 isocitrate dehydrogenase; Validated; Region: PRK07362 691437002160 malate dehydrogenase; Reviewed; Region: PRK06223 691437002161 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 691437002162 NAD(P) binding site [chemical binding]; other site 691437002163 dimer interface [polypeptide binding]; other site 691437002164 tetramer (dimer of dimers) interface [polypeptide binding]; other site 691437002165 substrate binding site [chemical binding]; other site 691437002166 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 691437002167 active site 2 [active] 691437002168 active site 1 [active] 691437002169 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 691437002170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437002171 active site 691437002172 phosphorylation site [posttranslational modification] 691437002173 intermolecular recognition site; other site 691437002174 dimerization interface [polypeptide binding]; other site 691437002175 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 691437002176 DNA binding site [nucleotide binding] 691437002177 HAMP domain; Region: HAMP; pfam00672 691437002178 dimerization interface [polypeptide binding]; other site 691437002179 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 691437002180 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 691437002181 putative active site [active] 691437002182 heme pocket [chemical binding]; other site 691437002183 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437002184 dimer interface [polypeptide binding]; other site 691437002185 phosphorylation site [posttranslational modification] 691437002186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437002187 ATP binding site [chemical binding]; other site 691437002188 Mg2+ binding site [ion binding]; other site 691437002189 G-X-G motif; other site 691437002190 DNA polymerase I; Provisional; Region: PRK05755 691437002191 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 691437002192 active site 691437002193 metal binding site 1 [ion binding]; metal-binding site 691437002194 putative 5' ssDNA interaction site; other site 691437002195 metal binding site 3; metal-binding site 691437002196 metal binding site 2 [ion binding]; metal-binding site 691437002197 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 691437002198 putative DNA binding site [nucleotide binding]; other site 691437002199 putative metal binding site [ion binding]; other site 691437002200 DEDDy 3'-5' exonuclease domain of family-A DNA polymerases; Region: DNA_polA_exo; cd06128 691437002201 active site 691437002202 catalytic site [active] 691437002203 substrate binding site [chemical binding]; other site 691437002204 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 691437002205 active site 691437002206 DNA binding site [nucleotide binding] 691437002207 catalytic site [active] 691437002208 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 691437002209 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 691437002210 DNA binding site [nucleotide binding] 691437002211 catalytic residue [active] 691437002212 H2TH interface [polypeptide binding]; other site 691437002213 putative catalytic residues [active] 691437002214 turnover-facilitating residue; other site 691437002215 intercalation triad [nucleotide binding]; other site 691437002216 8OG recognition residue [nucleotide binding]; other site 691437002217 putative reading head residues; other site 691437002218 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 691437002219 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 691437002220 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 691437002221 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 691437002222 CoA-binding site [chemical binding]; other site 691437002223 ATP-binding [chemical binding]; other site 691437002224 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 691437002225 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 691437002226 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 691437002227 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 691437002228 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 691437002229 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 691437002230 ATP cone domain; Region: ATP-cone; pfam03477 691437002231 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 691437002232 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 691437002233 primosomal protein DnaI; Reviewed; Region: PRK08939 691437002234 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 691437002235 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437002236 Walker A motif; other site 691437002237 ATP binding site [chemical binding]; other site 691437002238 Walker B motif; other site 691437002239 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 691437002240 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 691437002241 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 691437002242 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 691437002243 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 691437002244 active site 691437002245 dimer interface [polypeptide binding]; other site 691437002246 motif 1; other site 691437002247 motif 2; other site 691437002248 motif 3; other site 691437002249 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 691437002250 anticodon binding site; other site 691437002251 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 691437002252 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 691437002253 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 691437002254 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 691437002255 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 691437002256 23S rRNA binding site [nucleotide binding]; other site 691437002257 L21 binding site [polypeptide binding]; other site 691437002258 L13 binding site [polypeptide binding]; other site 691437002259 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 691437002260 dUTPase; Region: dUTPase_2; pfam08761 691437002261 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 691437002262 active site 691437002263 homodimer interface [polypeptide binding]; other site 691437002264 metal binding site [ion binding]; metal-binding site 691437002265 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 691437002266 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 691437002267 oligomer interface [polypeptide binding]; other site 691437002268 active site 691437002269 metal binding site [ion binding]; metal-binding site 691437002270 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 691437002271 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 691437002272 active site 691437002273 NTP binding site [chemical binding]; other site 691437002274 metal binding triad [ion binding]; metal-binding site 691437002275 antibiotic binding site [chemical binding]; other site 691437002276 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 691437002277 methionine sulfoxide reductase A; Provisional; Region: PRK14054 691437002278 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 691437002279 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 691437002280 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 691437002281 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 691437002282 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 691437002283 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 691437002284 dimer interface [polypeptide binding]; other site 691437002285 motif 1; other site 691437002286 active site 691437002287 motif 2; other site 691437002288 motif 3; other site 691437002289 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 691437002290 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 691437002291 putative tRNA-binding site [nucleotide binding]; other site 691437002292 B3/4 domain; Region: B3_4; pfam03483 691437002293 tRNA synthetase B5 domain; Region: B5; smart00874 691437002294 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 691437002295 dimer interface [polypeptide binding]; other site 691437002296 motif 1; other site 691437002297 motif 3; other site 691437002298 motif 2; other site 691437002299 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 691437002300 DNA binding domain, excisionase family; Region: excise; TIGR01764 691437002301 PBP superfamily domain; Region: PBP_like; pfam12727 691437002302 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 691437002303 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 691437002304 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 691437002305 camphor resistance protein CrcB; Provisional; Region: PRK14205 691437002306 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 691437002307 Alkaline phosphatase homologues; Region: alkPPc; smart00098 691437002308 active site 691437002309 dimer interface [polypeptide binding]; other site 691437002310 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 691437002311 MarR family; Region: MarR; pfam01047 691437002312 MMPL family; Region: MMPL; pfam03176 691437002313 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 691437002314 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 691437002315 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 691437002316 potential catalytic triad [active] 691437002317 conserved cys residue [active] 691437002318 ribonuclease HIII; Provisional; Region: PRK00996 691437002319 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 691437002320 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 691437002321 RNA/DNA hybrid binding site [nucleotide binding]; other site 691437002322 active site 691437002323 cell division protein ZapA; Provisional; Region: PRK14126 691437002324 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 691437002325 Colicin V production protein; Region: Colicin_V; pfam02674 691437002326 hypothetical protein; Provisional; Region: PRK08609 691437002327 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 691437002328 active site 691437002329 primer binding site [nucleotide binding]; other site 691437002330 NTP binding site [chemical binding]; other site 691437002331 metal binding triad [ion binding]; metal-binding site 691437002332 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 691437002333 active site 691437002334 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 691437002335 MutS domain III; Region: MutS_III; pfam05192 691437002336 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 691437002337 Walker A/P-loop; other site 691437002338 ATP binding site [chemical binding]; other site 691437002339 Q-loop/lid; other site 691437002340 ABC transporter signature motif; other site 691437002341 Walker B; other site 691437002342 D-loop; other site 691437002343 H-loop/switch region; other site 691437002344 Smr domain; Region: Smr; pfam01713 691437002345 Predicted membrane protein [Function unknown]; Region: COG3766 691437002346 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 691437002347 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 691437002348 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 691437002349 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 691437002350 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 691437002351 acyl-activating enzyme (AAE) consensus motif; other site 691437002352 putative AMP binding site [chemical binding]; other site 691437002353 putative active site [active] 691437002354 putative CoA binding site [chemical binding]; other site 691437002355 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 691437002356 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 691437002357 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 691437002358 enoyl-CoA hydratase; Provisional; Region: PRK07658 691437002359 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 691437002360 substrate binding site [chemical binding]; other site 691437002361 oxyanion hole (OAH) forming residues; other site 691437002362 trimer interface [polypeptide binding]; other site 691437002363 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 691437002364 Ligand binding site [chemical binding]; other site 691437002365 Electron transfer flavoprotein domain; Region: ETF; pfam01012 691437002366 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 691437002367 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 691437002368 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 691437002369 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 691437002370 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 691437002371 catalytic residues [active] 691437002372 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 691437002373 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437002374 NAD(P) binding site [chemical binding]; other site 691437002375 active site 691437002376 Sulfatase; Region: Sulfatase; cl17466 691437002377 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 691437002378 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 691437002379 Ligand binding site; other site 691437002380 Putative Catalytic site; other site 691437002381 DXD motif; other site 691437002382 Iron permease FTR1 family; Region: FTR1; cl00475 691437002383 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 691437002384 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 691437002385 GIY-YIG motif/motif A; other site 691437002386 active site 691437002387 catalytic site [active] 691437002388 putative DNA binding site [nucleotide binding]; other site 691437002389 metal binding site [ion binding]; metal-binding site 691437002390 UvrB/uvrC motif; Region: UVR; pfam02151 691437002391 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 691437002392 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 691437002393 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 691437002394 putative Iron-sulfur protein interface [polypeptide binding]; other site 691437002395 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 691437002396 proximal heme binding site [chemical binding]; other site 691437002397 distal heme binding site [chemical binding]; other site 691437002398 putative dimer interface [polypeptide binding]; other site 691437002399 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 691437002400 L-aspartate oxidase; Provisional; Region: PRK06175 691437002401 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 691437002402 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 691437002403 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 691437002404 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 691437002405 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 691437002406 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 691437002407 DNA binding residues [nucleotide binding] 691437002408 dimerization interface [polypeptide binding]; other site 691437002409 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 691437002410 MarR family; Region: MarR; pfam01047 691437002411 glutamate racemase; Provisional; Region: PRK00865 691437002412 Spore germination protein [General function prediction only]; Region: COG5401 691437002413 Sporulation and spore germination; Region: Germane; pfam10646 691437002414 Sporulation and spore germination; Region: Germane; pfam10646 691437002415 ribonuclease PH; Reviewed; Region: rph; PRK00173 691437002416 Ribonuclease PH; Region: RNase_PH_bact; cd11362 691437002417 hexamer interface [polypeptide binding]; other site 691437002418 active site 691437002419 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 691437002420 active site 691437002421 dimerization interface [polypeptide binding]; other site 691437002422 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 691437002423 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 691437002424 active site 691437002425 metal binding site [ion binding]; metal-binding site 691437002426 homotetramer interface [polypeptide binding]; other site 691437002427 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 691437002428 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 691437002429 homodimer interface [polypeptide binding]; other site 691437002430 substrate-cofactor binding pocket; other site 691437002431 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437002432 catalytic residue [active] 691437002433 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 691437002434 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 691437002435 PYR/PP interface [polypeptide binding]; other site 691437002436 dimer interface [polypeptide binding]; other site 691437002437 TPP binding site [chemical binding]; other site 691437002438 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 691437002439 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 691437002440 TPP-binding site [chemical binding]; other site 691437002441 dimer interface [polypeptide binding]; other site 691437002442 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 691437002443 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 691437002444 putative valine binding site [chemical binding]; other site 691437002445 dimer interface [polypeptide binding]; other site 691437002446 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 691437002447 ketol-acid reductoisomerase; Provisional; Region: PRK05479 691437002448 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 691437002449 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 691437002450 2-isopropylmalate synthase; Validated; Region: PRK00915 691437002451 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 691437002452 active site 691437002453 catalytic residues [active] 691437002454 metal binding site [ion binding]; metal-binding site 691437002455 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 691437002456 tartrate dehydrogenase; Region: TTC; TIGR02089 691437002457 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 691437002458 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 691437002459 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 691437002460 substrate binding site [chemical binding]; other site 691437002461 ligand binding site [chemical binding]; other site 691437002462 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 691437002463 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 691437002464 substrate binding site [chemical binding]; other site 691437002465 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 691437002466 binding surface 691437002467 Tetratricopeptide repeat; Region: TPR_16; pfam13432 691437002468 TPR motif; other site 691437002469 trigger factor; Provisional; Region: tig; PRK01490 691437002470 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 691437002471 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 691437002472 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 691437002473 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 691437002474 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437002475 Walker A motif; other site 691437002476 ATP binding site [chemical binding]; other site 691437002477 Walker B motif; other site 691437002478 arginine finger; other site 691437002479 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 691437002480 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 691437002481 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437002482 Walker A motif; other site 691437002483 ATP binding site [chemical binding]; other site 691437002484 Walker B motif; other site 691437002485 arginine finger; other site 691437002486 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 691437002487 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 691437002488 Found in ATP-dependent protease La (LON); Region: LON; smart00464 691437002489 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437002490 Walker A motif; other site 691437002491 ATP binding site [chemical binding]; other site 691437002492 Walker B motif; other site 691437002493 arginine finger; other site 691437002494 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 691437002495 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 691437002496 G1 box; other site 691437002497 GTP/Mg2+ binding site [chemical binding]; other site 691437002498 Switch I region; other site 691437002499 G2 box; other site 691437002500 G3 box; other site 691437002501 Switch II region; other site 691437002502 G4 box; other site 691437002503 G5 box; other site 691437002504 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 691437002505 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 691437002506 tRNA; other site 691437002507 putative tRNA binding site [nucleotide binding]; other site 691437002508 putative NADP binding site [chemical binding]; other site 691437002509 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 691437002510 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 691437002511 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 691437002512 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 691437002513 domain interfaces; other site 691437002514 active site 691437002515 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 691437002516 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 691437002517 active site 691437002518 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 691437002519 dimer interface [polypeptide binding]; other site 691437002520 active site 691437002521 Schiff base residues; other site 691437002522 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 691437002523 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 691437002524 inhibitor-cofactor binding pocket; inhibition site 691437002525 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437002526 catalytic residue [active] 691437002527 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 691437002528 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 691437002529 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 691437002530 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 691437002531 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 691437002532 active site 691437002533 HIGH motif; other site 691437002534 nucleotide binding site [chemical binding]; other site 691437002535 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 691437002536 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 691437002537 active site 691437002538 KMSKS motif; other site 691437002539 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 691437002540 tRNA binding surface [nucleotide binding]; other site 691437002541 anticodon binding site; other site 691437002542 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 691437002543 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 691437002544 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 691437002545 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 691437002546 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 691437002547 metal ion-dependent adhesion site (MIDAS); other site 691437002548 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 691437002549 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 691437002550 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 691437002551 VanW like protein; Region: VanW; pfam04294 691437002552 G5 domain; Region: G5; pfam07501 691437002553 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 691437002554 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 691437002555 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 691437002556 Walker A motif; other site 691437002557 ATP binding site [chemical binding]; other site 691437002558 Walker B motif; other site 691437002559 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 691437002560 Mitochondrial ribosomal death-associated protein 3; Region: DAP3; pfam10236 691437002561 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 691437002562 Walker A motif; other site 691437002563 ATP binding site [chemical binding]; other site 691437002564 Walker B motif; other site 691437002565 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 691437002566 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 691437002567 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 691437002568 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 691437002569 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 691437002570 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 691437002571 Competence protein A; Region: Competence_A; pfam11104 691437002572 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 691437002573 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 691437002574 Maf-like protein; Region: Maf; pfam02545 691437002575 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 691437002576 active site 691437002577 dimer interface [polypeptide binding]; other site 691437002578 hypothetical protein; Reviewed; Region: PRK00024 691437002579 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 691437002580 helix-hairpin-helix signature motif; other site 691437002581 active site 691437002582 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 691437002583 MPN+ (JAMM) motif; other site 691437002584 Zinc-binding site [ion binding]; other site 691437002585 rod shape-determining protein MreB; Provisional; Region: PRK13927 691437002586 MreB and similar proteins; Region: MreB_like; cd10225 691437002587 nucleotide binding site [chemical binding]; other site 691437002588 Mg binding site [ion binding]; other site 691437002589 putative protofilament interaction site [polypeptide binding]; other site 691437002590 RodZ interaction site [polypeptide binding]; other site 691437002591 rod shape-determining protein MreC; Provisional; Region: PRK13922 691437002592 rod shape-determining protein MreC; Region: MreC; pfam04085 691437002593 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 691437002594 septum formation inhibitor; Reviewed; Region: minC; PRK00513 691437002595 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 691437002596 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 691437002597 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 691437002598 Switch I; other site 691437002599 Switch II; other site 691437002600 Peptidase family M23; Region: Peptidase_M23; pfam01551 691437002601 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 691437002602 Peptidase family M50; Region: Peptidase_M50; pfam02163 691437002603 active site 691437002604 putative substrate binding region [chemical binding]; other site 691437002605 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 691437002606 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 691437002607 hypothetical protein; Provisional; Region: PRK14553 691437002608 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 691437002609 GTPase CgtA; Reviewed; Region: obgE; PRK12297 691437002610 GTP1/OBG; Region: GTP1_OBG; pfam01018 691437002611 Obg GTPase; Region: Obg; cd01898 691437002612 G1 box; other site 691437002613 GTP/Mg2+ binding site [chemical binding]; other site 691437002614 Switch I region; other site 691437002615 G2 box; other site 691437002616 G3 box; other site 691437002617 Switch II region; other site 691437002618 G4 box; other site 691437002619 G5 box; other site 691437002620 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 691437002621 hypothetical protein; Provisional; Region: PRK04435 691437002622 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 691437002623 prephenate dehydratase; Provisional; Region: PRK11898 691437002624 Prephenate dehydratase; Region: PDT; pfam00800 691437002625 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 691437002626 putative L-Phe binding site [chemical binding]; other site 691437002627 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 691437002628 HTH domain; Region: HTH_11; pfam08279 691437002629 3H domain; Region: 3H; pfam02829 691437002630 cysteine desulfurase; Provisional; Region: PRK02948 691437002631 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 691437002632 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 691437002633 catalytic residue [active] 691437002634 L-aspartate oxidase; Provisional; Region: PRK08071 691437002635 L-aspartate oxidase; Provisional; Region: PRK06175 691437002636 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 691437002637 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 691437002638 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 691437002639 dimerization interface [polypeptide binding]; other site 691437002640 active site 691437002641 quinolinate synthetase; Provisional; Region: PRK09375 691437002642 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 691437002643 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 691437002644 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 691437002645 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 691437002646 NAD synthetase; Provisional; Region: PRK13980 691437002647 homodimer interface [polypeptide binding]; other site 691437002648 NAD binding pocket [chemical binding]; other site 691437002649 ATP binding pocket [chemical binding]; other site 691437002650 Mg binding site [ion binding]; other site 691437002651 active-site loop [active] 691437002652 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 691437002653 hypothetical protein; Validated; Region: PRK00110 691437002654 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 691437002655 BofC C-terminal domain; Region: BofC_C; pfam08955 691437002656 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 691437002657 RuvA N terminal domain; Region: RuvA_N; pfam01330 691437002658 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 691437002659 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437002660 Walker A motif; other site 691437002661 ATP binding site [chemical binding]; other site 691437002662 Walker B motif; other site 691437002663 arginine finger; other site 691437002664 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 691437002665 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 691437002666 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 691437002667 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 691437002668 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 691437002669 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 691437002670 Preprotein translocase subunit; Region: YajC; pfam02699 691437002671 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 691437002672 stage V sporulation protein B; Region: spore_V_B; TIGR02900 691437002673 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 691437002674 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 691437002675 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 691437002676 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 691437002677 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 691437002678 Protein export membrane protein; Region: SecD_SecF; pfam02355 691437002679 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 691437002680 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 691437002681 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 691437002682 DHH family; Region: DHH; pfam01368 691437002683 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 691437002684 DHHA1 domain; Region: DHHA1; pfam02272 691437002685 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 691437002686 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 691437002687 active site 691437002688 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 691437002689 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 691437002690 Zn2+ binding site [ion binding]; other site 691437002691 Mg2+ binding site [ion binding]; other site 691437002692 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 691437002693 synthetase active site [active] 691437002694 NTP binding site [chemical binding]; other site 691437002695 metal binding site [ion binding]; metal-binding site 691437002696 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 691437002697 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 691437002698 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 691437002699 putative active site [active] 691437002700 dimerization interface [polypeptide binding]; other site 691437002701 putative tRNAtyr binding site [nucleotide binding]; other site 691437002702 peroxiredoxin; Region: AhpC; TIGR03137 691437002703 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 691437002704 dimer interface [polypeptide binding]; other site 691437002705 decamer (pentamer of dimers) interface [polypeptide binding]; other site 691437002706 catalytic triad [active] 691437002707 peroxidatic and resolving cysteines [active] 691437002708 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 691437002709 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 691437002710 catalytic residue [active] 691437002711 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 691437002712 catalytic residues [active] 691437002713 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 691437002714 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 691437002715 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 691437002716 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 691437002717 dimer interface [polypeptide binding]; other site 691437002718 motif 1; other site 691437002719 active site 691437002720 motif 2; other site 691437002721 motif 3; other site 691437002722 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 691437002723 anticodon binding site; other site 691437002724 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 691437002725 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 691437002726 dimer interface [polypeptide binding]; other site 691437002727 anticodon binding site; other site 691437002728 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 691437002729 homodimer interface [polypeptide binding]; other site 691437002730 motif 1; other site 691437002731 active site 691437002732 motif 2; other site 691437002733 GAD domain; Region: GAD; pfam02938 691437002734 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 691437002735 motif 3; other site 691437002736 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 691437002737 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 691437002738 putative ATP binding site [chemical binding]; other site 691437002739 putative substrate interface [chemical binding]; other site 691437002740 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 691437002741 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 691437002742 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 691437002743 Protein export membrane protein; Region: SecD_SecF; cl14618 691437002744 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 691437002745 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 691437002746 recombination factor protein RarA; Reviewed; Region: PRK13342 691437002747 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437002748 Walker A motif; other site 691437002749 ATP binding site [chemical binding]; other site 691437002750 Walker B motif; other site 691437002751 arginine finger; other site 691437002752 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 691437002753 Predicted transcriptional regulator [Transcription]; Region: COG1959 691437002754 Transcriptional regulator; Region: Rrf2; pfam02082 691437002755 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 691437002756 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 691437002757 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 691437002758 catalytic residue [active] 691437002759 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 691437002760 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 691437002761 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 691437002762 TPR repeat; Region: TPR_11; pfam13414 691437002763 binding surface 691437002764 TPR motif; other site 691437002765 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 691437002766 binding surface 691437002767 TPR motif; other site 691437002768 TPR repeat; Region: TPR_11; pfam13414 691437002769 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 691437002770 binding surface 691437002771 TPR motif; other site 691437002772 TPR repeat; Region: TPR_11; pfam13414 691437002773 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 691437002774 AAA domain; Region: AAA_30; pfam13604 691437002775 Family description; Region: UvrD_C_2; pfam13538 691437002776 PRC-barrel domain; Region: PRC; pfam05239 691437002777 PRC-barrel domain; Region: PRC; pfam05239 691437002778 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 691437002779 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 691437002780 Domain of unknown function DUF20; Region: UPF0118; pfam01594 691437002781 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 691437002782 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 691437002783 motif 1; other site 691437002784 active site 691437002785 motif 2; other site 691437002786 motif 3; other site 691437002787 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 691437002788 DHHA1 domain; Region: DHHA1; pfam02272 691437002789 hypothetical protein; Provisional; Region: PRK05473 691437002790 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 691437002791 hypothetical protein; Provisional; Region: PRK13678 691437002792 YceG-like family; Region: YceG; pfam02618 691437002793 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 691437002794 dimerization interface [polypeptide binding]; other site 691437002795 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 691437002796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437002797 S-adenosylmethionine binding site [chemical binding]; other site 691437002798 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 691437002799 Peptidase family U32; Region: Peptidase_U32; pfam01136 691437002800 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 691437002801 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 691437002802 Peptidase family U32; Region: Peptidase_U32; pfam01136 691437002803 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 691437002804 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 691437002805 Sugar specificity; other site 691437002806 Pyrimidine base specificity; other site 691437002807 ATP-binding site [chemical binding]; other site 691437002808 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 691437002809 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 691437002810 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 691437002811 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 691437002812 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 691437002813 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 691437002814 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 691437002815 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 691437002816 Methyltransferase domain; Region: Methyltransf_23; pfam13489 691437002817 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437002818 S-adenosylmethionine binding site [chemical binding]; other site 691437002819 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 691437002820 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 691437002821 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 691437002822 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 691437002823 dimer interface [polypeptide binding]; other site 691437002824 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437002825 catalytic residue [active] 691437002826 cystathionine beta-lyase; Provisional; Region: PRK07671 691437002827 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 691437002828 homodimer interface [polypeptide binding]; other site 691437002829 substrate-cofactor binding pocket; other site 691437002830 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437002831 catalytic residue [active] 691437002832 YrhC-like protein; Region: YrhC; pfam14143 691437002833 sporulation sigma factor SigK; Reviewed; Region: PRK05803 691437002834 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 691437002835 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 691437002836 DNA binding residues [nucleotide binding] 691437002837 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 691437002838 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 691437002839 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 691437002840 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 691437002841 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 691437002842 Domain of unknown function DUF20; Region: UPF0118; pfam01594 691437002843 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 691437002844 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 691437002845 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 691437002846 ligand binding site [chemical binding]; other site 691437002847 flagellar motor protein MotA; Validated; Region: PRK08124 691437002848 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 691437002849 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 691437002850 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 691437002851 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 691437002852 Sporulation inhibitor A; Region: Sda; pfam08970 691437002853 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 691437002854 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 691437002855 active site 691437002856 motif I; other site 691437002857 motif II; other site 691437002858 GTPase YqeH; Provisional; Region: PRK13796 691437002859 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 691437002860 GTP/Mg2+ binding site [chemical binding]; other site 691437002861 G4 box; other site 691437002862 G5 box; other site 691437002863 G1 box; other site 691437002864 Switch I region; other site 691437002865 G2 box; other site 691437002866 G3 box; other site 691437002867 Switch II region; other site 691437002868 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 691437002869 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 691437002870 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 691437002871 shikimate binding site; other site 691437002872 NAD(P) binding site [chemical binding]; other site 691437002873 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 691437002874 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 691437002875 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 691437002876 active site 691437002877 (T/H)XGH motif; other site 691437002878 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 691437002879 Zn2+ binding site [ion binding]; other site 691437002880 Mg2+ binding site [ion binding]; other site 691437002881 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 691437002882 Methyltransferase domain; Region: Methyltransf_23; pfam13489 691437002883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437002884 S-adenosylmethionine binding site [chemical binding]; other site 691437002885 late competence protein ComER; Validated; Region: PRK07680 691437002886 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 691437002887 SLBB domain; Region: SLBB; pfam10531 691437002888 comEA protein; Region: comE; TIGR01259 691437002889 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 691437002890 catalytic motif [active] 691437002891 Zn binding site [ion binding]; other site 691437002892 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 691437002893 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 691437002894 Competence protein; Region: Competence; pfam03772 691437002895 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 691437002896 YqzM-like protein; Region: YqzM; pfam14141 691437002897 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 691437002898 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 691437002899 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 691437002900 germination protease; Provisional; Region: PRK02858 691437002901 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 691437002902 stage II sporulation protein P; Region: spore_II_P; TIGR02867 691437002903 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 691437002904 GTP-binding protein LepA; Provisional; Region: PRK05433 691437002905 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 691437002906 G1 box; other site 691437002907 putative GEF interaction site [polypeptide binding]; other site 691437002908 GTP/Mg2+ binding site [chemical binding]; other site 691437002909 Switch I region; other site 691437002910 G2 box; other site 691437002911 G3 box; other site 691437002912 Switch II region; other site 691437002913 G4 box; other site 691437002914 G5 box; other site 691437002915 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 691437002916 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 691437002917 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 691437002918 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 691437002919 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 691437002920 FeS/SAM binding site; other site 691437002921 HemN C-terminal domain; Region: HemN_C; pfam06969 691437002922 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 691437002923 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 691437002924 heat shock protein GrpE; Provisional; Region: PRK14140 691437002925 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 691437002926 dimer interface [polypeptide binding]; other site 691437002927 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 691437002928 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 691437002929 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 691437002930 nucleotide binding site [chemical binding]; other site 691437002931 NEF interaction site [polypeptide binding]; other site 691437002932 SBD interface [polypeptide binding]; other site 691437002933 chaperone protein DnaJ; Provisional; Region: PRK14280 691437002934 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 691437002935 HSP70 interaction site [polypeptide binding]; other site 691437002936 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 691437002937 substrate binding site [polypeptide binding]; other site 691437002938 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 691437002939 Zn binding sites [ion binding]; other site 691437002940 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 691437002941 dimer interface [polypeptide binding]; other site 691437002942 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 691437002943 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437002944 S-adenosylmethionine binding site [chemical binding]; other site 691437002945 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 691437002946 RNA methyltransferase, RsmE family; Region: TIGR00046 691437002947 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 691437002948 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 691437002949 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 691437002950 FeS/SAM binding site; other site 691437002951 TRAM domain; Region: TRAM; pfam01938 691437002952 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 691437002953 intersubunit interface [polypeptide binding]; other site 691437002954 active site 691437002955 catalytic residue [active] 691437002956 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 691437002957 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 691437002958 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 691437002959 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 691437002960 Yqey-like protein; Region: YqeY; pfam09424 691437002961 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 691437002962 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 691437002963 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 691437002964 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 691437002965 PhoH-like protein; Region: PhoH; pfam02562 691437002966 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 691437002967 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 691437002968 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 691437002969 Zn2+ binding site [ion binding]; other site 691437002970 Mg2+ binding site [ion binding]; other site 691437002971 metal-binding heat shock protein; Provisional; Region: PRK00016 691437002972 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 691437002973 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 691437002974 active site 691437002975 catalytic motif [active] 691437002976 Zn binding site [ion binding]; other site 691437002977 GTPase Era; Reviewed; Region: era; PRK00089 691437002978 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 691437002979 G1 box; other site 691437002980 GTP/Mg2+ binding site [chemical binding]; other site 691437002981 Switch I region; other site 691437002982 G2 box; other site 691437002983 Switch II region; other site 691437002984 G3 box; other site 691437002985 G4 box; other site 691437002986 G5 box; other site 691437002987 KH domain; Region: KH_2; pfam07650 691437002988 YqzL-like protein; Region: YqzL; pfam14006 691437002989 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 691437002990 Recombination protein O N terminal; Region: RecO_N; pfam11967 691437002991 Recombination protein O C terminal; Region: RecO_C; pfam02565 691437002992 HTH domain; Region: HTH_11; pfam08279 691437002993 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 691437002994 FOG: CBS domain [General function prediction only]; Region: COG0517 691437002995 PEP synthetase regulatory protein; Provisional; Region: PRK05339 691437002996 DNA primase; Validated; Region: dnaG; PRK05667 691437002997 CHC2 zinc finger; Region: zf-CHC2; pfam01807 691437002998 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 691437002999 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 691437003000 active site 691437003001 metal binding site [ion binding]; metal-binding site 691437003002 interdomain interaction site; other site 691437003003 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 691437003004 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 691437003005 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 691437003006 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 691437003007 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 691437003008 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 691437003009 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 691437003010 DNA binding residues [nucleotide binding] 691437003011 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 691437003012 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 691437003013 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 691437003014 Family of unknown function (DUF633); Region: DUF633; pfam04816 691437003015 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 691437003016 Uncharacterized conserved protein [Function unknown]; Region: COG0327 691437003017 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 691437003018 Uncharacterized conserved protein [Function unknown]; Region: COG0327 691437003019 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 691437003020 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 691437003021 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 691437003022 YqfQ-like protein; Region: YqfQ; pfam14181 691437003023 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 691437003024 DEAD-like helicases superfamily; Region: DEXDc; smart00487 691437003025 ATP binding site [chemical binding]; other site 691437003026 Mg++ binding site [ion binding]; other site 691437003027 motif III; other site 691437003028 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 691437003029 nucleotide binding region [chemical binding]; other site 691437003030 ATP-binding site [chemical binding]; other site 691437003031 endonuclease IV; Provisional; Region: PRK01060 691437003032 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 691437003033 AP (apurinic/apyrimidinic) site pocket; other site 691437003034 DNA interaction; other site 691437003035 Metal-binding active site; metal-binding site 691437003036 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 691437003037 Uncharacterized conserved protein [Function unknown]; Region: COG1284 691437003038 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 691437003039 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 691437003040 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 691437003041 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 691437003042 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 691437003043 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 691437003044 ABC-ATPase subunit interface; other site 691437003045 dimer interface [polypeptide binding]; other site 691437003046 putative PBP binding regions; other site 691437003047 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 691437003048 metal binding site 2 [ion binding]; metal-binding site 691437003049 putative DNA binding helix; other site 691437003050 metal binding site 1 [ion binding]; metal-binding site 691437003051 dimer interface [polypeptide binding]; other site 691437003052 structural Zn2+ binding site [ion binding]; other site 691437003053 Uncharacterized conserved protein [Function unknown]; Region: COG5663 691437003054 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 691437003055 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 691437003056 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 691437003057 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 691437003058 phosphate binding protein; Region: ptsS_2; TIGR02136 691437003059 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 691437003060 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 691437003061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437003062 dimer interface [polypeptide binding]; other site 691437003063 conserved gate region; other site 691437003064 putative PBP binding loops; other site 691437003065 ABC-ATPase subunit interface; other site 691437003066 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 691437003067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437003068 dimer interface [polypeptide binding]; other site 691437003069 conserved gate region; other site 691437003070 putative PBP binding loops; other site 691437003071 ABC-ATPase subunit interface; other site 691437003072 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 691437003073 HAMP domain; Region: HAMP; pfam00672 691437003074 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 691437003075 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 691437003076 dimer interface [polypeptide binding]; other site 691437003077 putative CheW interface [polypeptide binding]; other site 691437003078 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 691437003079 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 691437003080 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 691437003081 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437003082 Major Facilitator Superfamily; Region: MFS_1; pfam07690 691437003083 putative substrate translocation pore; other site 691437003084 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 691437003085 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 691437003086 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 691437003087 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 691437003088 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 691437003089 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 691437003090 Walker A/P-loop; other site 691437003091 ATP binding site [chemical binding]; other site 691437003092 Q-loop/lid; other site 691437003093 ABC transporter signature motif; other site 691437003094 Walker B; other site 691437003095 D-loop; other site 691437003096 H-loop/switch region; other site 691437003097 YceG-like family; Region: YceG; pfam02618 691437003098 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 691437003099 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 691437003100 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 691437003101 Integral membrane protein DUF92; Region: DUF92; pfam01940 691437003102 Rhomboid family; Region: Rhomboid; pfam01694 691437003103 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 691437003104 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 691437003105 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 691437003106 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 691437003107 nucleotide binding site [chemical binding]; other site 691437003108 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 691437003109 putative active site [active] 691437003110 Zn binding site [ion binding]; other site 691437003111 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 691437003112 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 691437003113 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 691437003114 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 691437003115 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 691437003116 putative DNA binding site [nucleotide binding]; other site 691437003117 dimerization interface [polypeptide binding]; other site 691437003118 Predicted transcriptional regulator [Transcription]; Region: COG2345 691437003119 putative Zn2+ binding site [ion binding]; other site 691437003120 Type II/IV secretion system protein; Region: T2SE; pfam00437 691437003121 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 691437003122 Walker A motif; other site 691437003123 ATP binding site [chemical binding]; other site 691437003124 Walker B motif; other site 691437003125 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 691437003126 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 691437003127 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 691437003128 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 691437003129 ComG operon protein 7; Region: ComGG; pfam14173 691437003130 YqzE-like protein; Region: YqzE; pfam14038 691437003131 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 691437003132 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 691437003133 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 691437003134 ATP binding site [chemical binding]; other site 691437003135 putative Mg++ binding site [ion binding]; other site 691437003136 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 691437003137 nucleotide binding region [chemical binding]; other site 691437003138 ATP-binding site [chemical binding]; other site 691437003139 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 691437003140 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 691437003141 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 691437003142 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 691437003143 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 691437003144 tetramer interface [polypeptide binding]; other site 691437003145 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437003146 catalytic residue [active] 691437003147 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 691437003148 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 691437003149 tetramer interface [polypeptide binding]; other site 691437003150 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437003151 catalytic residue [active] 691437003152 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 691437003153 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 691437003154 active site 691437003155 catalytic tetrad [active] 691437003156 MarR family; Region: MarR_2; pfam12802 691437003157 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 691437003158 ROK family; Region: ROK; pfam00480 691437003159 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 691437003160 active site residue [active] 691437003161 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 691437003162 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08115 691437003163 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 691437003164 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 691437003165 active site 691437003166 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 691437003167 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 691437003168 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 691437003169 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 691437003170 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 691437003171 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 691437003172 active site 691437003173 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 691437003174 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 691437003175 FeS/SAM binding site; other site 691437003176 manganese transport transcriptional regulator; Provisional; Region: PRK03902 691437003177 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 691437003178 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 691437003179 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 691437003180 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 691437003181 active site 691437003182 nucleophile elbow; other site 691437003183 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 691437003184 Conserved membrane protein YqhR; Region: YqhR; pfam11085 691437003185 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 691437003186 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 691437003187 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 691437003188 active site 691437003189 elongation factor P; Validated; Region: PRK00529 691437003190 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 691437003191 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 691437003192 RNA binding site [nucleotide binding]; other site 691437003193 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 691437003194 RNA binding site [nucleotide binding]; other site 691437003195 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 691437003196 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 691437003197 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437003198 Walker A motif; other site 691437003199 ATP binding site [chemical binding]; other site 691437003200 Walker B motif; other site 691437003201 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 691437003202 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 691437003203 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 691437003204 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 691437003205 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 691437003206 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 691437003207 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 691437003208 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 691437003209 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 691437003210 carboxyltransferase (CT) interaction site; other site 691437003211 biotinylation site [posttranslational modification]; other site 691437003212 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 691437003213 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 691437003214 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 691437003215 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 691437003216 Asp23 family; Region: Asp23; pfam03780 691437003217 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 691437003218 putative RNA binding site [nucleotide binding]; other site 691437003219 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 691437003220 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 691437003221 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 691437003222 homodimer interface [polypeptide binding]; other site 691437003223 NADP binding site [chemical binding]; other site 691437003224 substrate binding site [chemical binding]; other site 691437003225 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 691437003226 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 691437003227 generic binding surface II; other site 691437003228 generic binding surface I; other site 691437003229 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 691437003230 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 691437003231 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 691437003232 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 691437003233 substrate binding pocket [chemical binding]; other site 691437003234 chain length determination region; other site 691437003235 substrate-Mg2+ binding site; other site 691437003236 catalytic residues [active] 691437003237 aspartate-rich region 1; other site 691437003238 active site lid residues [active] 691437003239 aspartate-rich region 2; other site 691437003240 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 691437003241 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 691437003242 TPP-binding site; other site 691437003243 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 691437003244 PYR/PP interface [polypeptide binding]; other site 691437003245 dimer interface [polypeptide binding]; other site 691437003246 TPP binding site [chemical binding]; other site 691437003247 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 691437003248 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 691437003249 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 691437003250 RNA binding surface [nucleotide binding]; other site 691437003251 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 691437003252 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 691437003253 arginine repressor; Provisional; Region: PRK04280 691437003254 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 691437003255 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 691437003256 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 691437003257 Walker A/P-loop; other site 691437003258 ATP binding site [chemical binding]; other site 691437003259 Q-loop/lid; other site 691437003260 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 691437003261 ABC transporter signature motif; other site 691437003262 Walker B; other site 691437003263 D-loop; other site 691437003264 H-loop/switch region; other site 691437003265 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 691437003266 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 691437003267 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 691437003268 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 691437003269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437003270 active site 691437003271 phosphorylation site [posttranslational modification] 691437003272 intermolecular recognition site; other site 691437003273 dimerization interface [polypeptide binding]; other site 691437003274 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 691437003275 YycC-like protein; Region: YycC; pfam14174 691437003276 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 691437003277 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 691437003278 active site 691437003279 catalytic site [active] 691437003280 metal binding site [ion binding]; metal-binding site 691437003281 dimer interface [polypeptide binding]; other site 691437003282 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 691437003283 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 691437003284 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 691437003285 putative active site [active] 691437003286 heme pocket [chemical binding]; other site 691437003287 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 691437003288 putative active site [active] 691437003289 heme pocket [chemical binding]; other site 691437003290 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437003291 Walker A motif; other site 691437003292 ATP binding site [chemical binding]; other site 691437003293 Walker B motif; other site 691437003294 arginine finger; other site 691437003295 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 691437003296 phosphate butyryltransferase; Validated; Region: PRK07742 691437003297 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 691437003298 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 691437003299 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 691437003300 NAD binding site [chemical binding]; other site 691437003301 Phe binding site; other site 691437003302 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 691437003303 nucleotide binding site [chemical binding]; other site 691437003304 Acetokinase family; Region: Acetate_kinase; cl17229 691437003305 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 691437003306 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 691437003307 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 691437003308 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 691437003309 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 691437003310 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 691437003311 tetramer interface [polypeptide binding]; other site 691437003312 TPP-binding site [chemical binding]; other site 691437003313 heterodimer interface [polypeptide binding]; other site 691437003314 phosphorylation loop region [posttranslational modification] 691437003315 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 691437003316 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 691437003317 alpha subunit interface [polypeptide binding]; other site 691437003318 TPP binding site [chemical binding]; other site 691437003319 heterodimer interface [polypeptide binding]; other site 691437003320 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 691437003321 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 691437003322 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 691437003323 E3 interaction surface; other site 691437003324 lipoyl attachment site [posttranslational modification]; other site 691437003325 e3 binding domain; Region: E3_binding; pfam02817 691437003326 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 691437003327 Uncharacterized conserved protein [Function unknown]; Region: COG3391 691437003328 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 691437003329 structural tetrad; other site 691437003330 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 691437003331 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437003332 active site 691437003333 phosphorylation site [posttranslational modification] 691437003334 intermolecular recognition site; other site 691437003335 dimerization interface [polypeptide binding]; other site 691437003336 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 691437003337 DNA binding site [nucleotide binding] 691437003338 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 691437003339 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 691437003340 dimerization interface [polypeptide binding]; other site 691437003341 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437003342 dimer interface [polypeptide binding]; other site 691437003343 phosphorylation site [posttranslational modification] 691437003344 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437003345 ATP binding site [chemical binding]; other site 691437003346 Mg2+ binding site [ion binding]; other site 691437003347 G-X-G motif; other site 691437003348 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 691437003349 putative active site [active] 691437003350 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 691437003351 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 691437003352 heterodimer interface [polypeptide binding]; other site 691437003353 substrate interaction site [chemical binding]; other site 691437003354 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 691437003355 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 691437003356 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 691437003357 active site 691437003358 substrate binding site [chemical binding]; other site 691437003359 coenzyme B12 binding site [chemical binding]; other site 691437003360 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 691437003361 B12 binding site [chemical binding]; other site 691437003362 cobalt ligand [ion binding]; other site 691437003363 membrane ATPase/protein kinase; Provisional; Region: PRK09435 691437003364 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 691437003365 Walker A; other site 691437003366 Disulphide isomerase; Region: Disulph_isomer; pfam06491 691437003367 HipA-like C-terminal domain; Region: HipA_C; pfam07804 691437003368 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 691437003369 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 691437003370 active site 691437003371 NTP binding site [chemical binding]; other site 691437003372 metal binding triad [ion binding]; metal-binding site 691437003373 antibiotic binding site [chemical binding]; other site 691437003374 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 691437003375 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 691437003376 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 691437003377 Walker A/P-loop; other site 691437003378 ATP binding site [chemical binding]; other site 691437003379 Q-loop/lid; other site 691437003380 ABC transporter signature motif; other site 691437003381 Walker B; other site 691437003382 D-loop; other site 691437003383 H-loop/switch region; other site 691437003384 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 691437003385 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 691437003386 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 691437003387 Walker A/P-loop; other site 691437003388 ATP binding site [chemical binding]; other site 691437003389 Q-loop/lid; other site 691437003390 ABC transporter signature motif; other site 691437003391 Walker B; other site 691437003392 D-loop; other site 691437003393 H-loop/switch region; other site 691437003394 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 691437003395 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 691437003396 ABC transporter signature motif; other site 691437003397 Walker B; other site 691437003398 D-loop; other site 691437003399 H-loop/switch region; other site 691437003400 Predicted membrane protein [Function unknown]; Region: COG4129 691437003401 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 691437003402 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 691437003403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 691437003404 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 691437003405 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 691437003406 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 691437003407 dimer interface [polypeptide binding]; other site 691437003408 substrate binding site [chemical binding]; other site 691437003409 metal binding site [ion binding]; metal-binding site 691437003410 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 691437003411 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 691437003412 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 691437003413 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 691437003414 B12 binding site [chemical binding]; other site 691437003415 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 691437003416 FeS/SAM binding site; other site 691437003417 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 691437003418 hypothetical protein; Provisional; Region: PRK07206 691437003419 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 691437003420 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 691437003421 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 691437003422 G4 box; other site 691437003423 G5 box; other site 691437003424 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 691437003425 peptidase T-like protein; Region: PepT-like; TIGR01883 691437003426 metal binding site [ion binding]; metal-binding site 691437003427 putative dimer interface [polypeptide binding]; other site 691437003428 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 691437003429 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 691437003430 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 691437003431 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 691437003432 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 691437003433 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 691437003434 Walker A/P-loop; other site 691437003435 ATP binding site [chemical binding]; other site 691437003436 Q-loop/lid; other site 691437003437 ABC transporter signature motif; other site 691437003438 Walker B; other site 691437003439 D-loop; other site 691437003440 H-loop/switch region; other site 691437003441 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 691437003442 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 691437003443 dimer interface [polypeptide binding]; other site 691437003444 phosphorylation site [posttranslational modification] 691437003445 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437003446 ATP binding site [chemical binding]; other site 691437003447 Mg2+ binding site [ion binding]; other site 691437003448 G-X-G motif; other site 691437003449 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 691437003450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437003451 active site 691437003452 phosphorylation site [posttranslational modification] 691437003453 intermolecular recognition site; other site 691437003454 dimerization interface [polypeptide binding]; other site 691437003455 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 691437003456 DNA binding site [nucleotide binding] 691437003457 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 691437003458 beta-galactosidase; Region: BGL; TIGR03356 691437003459 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 691437003460 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 691437003461 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 691437003462 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 691437003463 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 691437003464 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 691437003465 ribonuclease Z; Region: RNase_Z; TIGR02651 691437003466 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 691437003467 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 691437003468 active site 691437003469 FMN binding site [chemical binding]; other site 691437003470 substrate binding site [chemical binding]; other site 691437003471 homotetramer interface [polypeptide binding]; other site 691437003472 catalytic residue [active] 691437003473 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679 691437003474 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 691437003475 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 691437003476 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 691437003477 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437003478 NAD(P) binding site [chemical binding]; other site 691437003479 active site 691437003480 YqzH-like protein; Region: YqzH; pfam14164 691437003481 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 691437003482 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 691437003483 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 691437003484 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 691437003485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437003486 putative substrate translocation pore; other site 691437003487 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 691437003488 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 691437003489 active site 691437003490 catalytic tetrad [active] 691437003491 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 691437003492 dimer interface [polypeptide binding]; other site 691437003493 ADP-ribose binding site [chemical binding]; other site 691437003494 active site 691437003495 nudix motif; other site 691437003496 metal binding site [ion binding]; metal-binding site 691437003497 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 691437003498 PHP-associated; Region: PHP_C; pfam13263 691437003499 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 691437003500 DNA binding site [nucleotide binding] 691437003501 stage II sporulation protein M; Region: spo_II_M; TIGR02831 691437003502 ferric uptake regulator; Provisional; Region: fur; PRK09462 691437003503 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 691437003504 metal binding site 2 [ion binding]; metal-binding site 691437003505 putative DNA binding helix; other site 691437003506 metal binding site 1 [ion binding]; metal-binding site 691437003507 dimer interface [polypeptide binding]; other site 691437003508 structural Zn2+ binding site [ion binding]; other site 691437003509 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 691437003510 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 691437003511 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 691437003512 active site 691437003513 Int/Topo IB signature motif; other site 691437003514 phosphopentomutase; Provisional; Region: PRK05362 691437003515 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 691437003516 purine nucleoside phosphorylase; Provisional; Region: PRK08202 691437003517 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 691437003518 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 691437003519 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 691437003520 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 691437003521 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 691437003522 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 691437003523 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 691437003524 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cd06844 691437003525 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 691437003526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437003527 ATP binding site [chemical binding]; other site 691437003528 Mg2+ binding site [ion binding]; other site 691437003529 G-X-G motif; other site 691437003530 sporulation sigma factor SigF; Validated; Region: PRK05572 691437003531 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 691437003532 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 691437003533 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 691437003534 DNA binding residues [nucleotide binding] 691437003535 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 691437003536 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 691437003537 SpoVA protein; Region: SpoVA; cl04298 691437003538 stage V sporulation protein AD; Validated; Region: PRK08304 691437003539 stage V sporulation protein AD; Provisional; Region: PRK12404 691437003540 SpoVA protein; Region: SpoVA; pfam03862 691437003541 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 691437003542 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 691437003543 diaminopimelate decarboxylase; Region: lysA; TIGR01048 691437003544 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 691437003545 active site 691437003546 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 691437003547 substrate binding site [chemical binding]; other site 691437003548 catalytic residues [active] 691437003549 dimer interface [polypeptide binding]; other site 691437003550 Predicted secreted protein [Function unknown]; Region: COG4086 691437003551 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 691437003552 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 691437003553 active site 691437003554 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 691437003555 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 691437003556 catalytic motif [active] 691437003557 Zn binding site [ion binding]; other site 691437003558 RibD C-terminal domain; Region: RibD_C; cl17279 691437003559 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 691437003560 Lumazine binding domain; Region: Lum_binding; pfam00677 691437003561 Lumazine binding domain; Region: Lum_binding; pfam00677 691437003562 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 691437003563 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 691437003564 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 691437003565 dimerization interface [polypeptide binding]; other site 691437003566 active site 691437003567 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 691437003568 homopentamer interface [polypeptide binding]; other site 691437003569 active site 691437003570 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 691437003571 Coenzyme A binding pocket [chemical binding]; other site 691437003572 Domain of unknown function (DUF309); Region: DUF309; pfam03745 691437003573 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 691437003574 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 691437003575 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 691437003576 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 691437003577 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 691437003578 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 691437003579 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 691437003580 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 691437003581 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 691437003582 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 691437003583 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 691437003584 RNA binding surface [nucleotide binding]; other site 691437003585 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 691437003586 active site 691437003587 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 691437003588 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 691437003589 catalytic residues [active] 691437003590 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 691437003591 Double zinc ribbon; Region: DZR; pfam12773 691437003592 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 691437003593 ResB-like family; Region: ResB; pfam05140 691437003594 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 691437003595 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 691437003596 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 691437003597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437003598 active site 691437003599 phosphorylation site [posttranslational modification] 691437003600 intermolecular recognition site; other site 691437003601 dimerization interface [polypeptide binding]; other site 691437003602 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 691437003603 DNA binding site [nucleotide binding] 691437003604 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 691437003605 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 691437003606 dimerization interface [polypeptide binding]; other site 691437003607 PAS domain; Region: PAS; smart00091 691437003608 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437003609 dimer interface [polypeptide binding]; other site 691437003610 phosphorylation site [posttranslational modification] 691437003611 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437003612 ATP binding site [chemical binding]; other site 691437003613 Mg2+ binding site [ion binding]; other site 691437003614 G-X-G motif; other site 691437003615 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 691437003616 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 691437003617 active site 691437003618 dimer interface [polypeptide binding]; other site 691437003619 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 691437003620 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 691437003621 active site 691437003622 trimer interface [polypeptide binding]; other site 691437003623 allosteric site; other site 691437003624 active site lid [active] 691437003625 hexamer (dimer of trimers) interface [polypeptide binding]; other site 691437003626 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 691437003627 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 691437003628 DNA-binding site [nucleotide binding]; DNA binding site 691437003629 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 691437003630 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 691437003631 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 691437003632 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 691437003633 active site turn [active] 691437003634 phosphorylation site [posttranslational modification] 691437003635 Transposase; Region: DEDD_Tnp_IS110; pfam01548 691437003636 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 691437003637 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 691437003638 Histidine kinase; Region: His_kinase; pfam06580 691437003639 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 691437003640 Mg2+ binding site [ion binding]; other site 691437003641 Response regulator receiver domain; Region: Response_reg; pfam00072 691437003642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437003643 active site 691437003644 phosphorylation site [posttranslational modification] 691437003645 intermolecular recognition site; other site 691437003646 dimerization interface [polypeptide binding]; other site 691437003647 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 691437003648 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 691437003649 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 691437003650 Site-specific recombinase; Region: SpecificRecomb; cl15411 691437003651 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 691437003652 amino acid transporter; Region: 2A0306; TIGR00909 691437003653 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 691437003654 pentamer interface [polypeptide binding]; other site 691437003655 dodecaamer interface [polypeptide binding]; other site 691437003656 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 691437003657 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 691437003658 nudix motif; other site 691437003659 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 691437003660 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 691437003661 putative binding site residues; other site 691437003662 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 691437003663 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 691437003664 putative PBP binding regions; other site 691437003665 ABC-ATPase subunit interface; other site 691437003666 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 691437003667 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 691437003668 Walker A/P-loop; other site 691437003669 ATP binding site [chemical binding]; other site 691437003670 Q-loop/lid; other site 691437003671 ABC transporter signature motif; other site 691437003672 Walker B; other site 691437003673 D-loop; other site 691437003674 H-loop/switch region; other site 691437003675 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 691437003676 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 691437003677 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 691437003678 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 691437003679 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437003680 homodimer interface [polypeptide binding]; other site 691437003681 catalytic residue [active] 691437003682 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363 691437003683 cobalamin synthase; Reviewed; Region: cobS; PRK00235 691437003684 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 691437003685 catalytic core [active] 691437003686 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363 691437003687 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 691437003688 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 691437003689 ATP binding site [chemical binding]; other site 691437003690 dimerization interface [polypeptide binding]; other site 691437003691 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 691437003692 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 691437003693 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 691437003694 DNA binding residues [nucleotide binding] 691437003695 histidinol-phosphatase; Provisional; Region: PRK07328 691437003696 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 691437003697 active site 691437003698 dimer interface [polypeptide binding]; other site 691437003699 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 691437003700 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 691437003701 ligand binding site [chemical binding]; other site 691437003702 NAD binding site [chemical binding]; other site 691437003703 dimerization interface [polypeptide binding]; other site 691437003704 catalytic site [active] 691437003705 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 691437003706 putative L-serine binding site [chemical binding]; other site 691437003707 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 691437003708 dimer interface [polypeptide binding]; other site 691437003709 substrate binding site [chemical binding]; other site 691437003710 metal binding sites [ion binding]; metal-binding site 691437003711 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 691437003712 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 691437003713 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 691437003714 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 691437003715 ATP binding site [chemical binding]; other site 691437003716 putative Mg++ binding site [ion binding]; other site 691437003717 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 691437003718 nucleotide binding region [chemical binding]; other site 691437003719 ATP-binding site [chemical binding]; other site 691437003720 CAAX protease self-immunity; Region: Abi; pfam02517 691437003721 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 691437003722 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 691437003723 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 691437003724 dimanganese center [ion binding]; other site 691437003725 CotJB protein; Region: CotJB; pfam12652 691437003726 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 691437003727 adaptor protein; Provisional; Region: PRK02899 691437003728 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 691437003729 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 691437003730 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 691437003731 NAD(P) binding site [chemical binding]; other site 691437003732 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 691437003733 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 691437003734 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 691437003735 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 691437003736 active site 691437003737 homotetramer interface [polypeptide binding]; other site 691437003738 homodimer interface [polypeptide binding]; other site 691437003739 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 691437003740 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 691437003741 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 691437003742 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 691437003743 germination protein YpeB; Region: spore_YpeB; TIGR02889 691437003744 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 691437003745 Flagellar protein YcgR; Region: YcgR_2; pfam12945 691437003746 PilZ domain; Region: PilZ; pfam07238 691437003747 cytidylate kinase; Provisional; Region: cmk; PRK00023 691437003748 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 691437003749 CMP-binding site; other site 691437003750 The sites determining sugar specificity; other site 691437003751 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 691437003752 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 691437003753 putative acyl-acceptor binding pocket; other site 691437003754 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 691437003755 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 691437003756 RNA binding site [nucleotide binding]; other site 691437003757 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 691437003758 RNA binding site [nucleotide binding]; other site 691437003759 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 691437003760 RNA binding site [nucleotide binding]; other site 691437003761 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 691437003762 RNA binding site [nucleotide binding]; other site 691437003763 YpzI-like protein; Region: YpzI; pfam14140 691437003764 YIEGIA protein; Region: YIEGIA; pfam14045 691437003765 GTP-binding protein Der; Reviewed; Region: PRK00093 691437003766 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 691437003767 G1 box; other site 691437003768 GTP/Mg2+ binding site [chemical binding]; other site 691437003769 Switch I region; other site 691437003770 G2 box; other site 691437003771 Switch II region; other site 691437003772 G3 box; other site 691437003773 G4 box; other site 691437003774 G5 box; other site 691437003775 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 691437003776 G1 box; other site 691437003777 GTP/Mg2+ binding site [chemical binding]; other site 691437003778 Switch I region; other site 691437003779 G2 box; other site 691437003780 G3 box; other site 691437003781 Switch II region; other site 691437003782 G4 box; other site 691437003783 G5 box; other site 691437003784 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 691437003785 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 691437003786 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 691437003787 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 691437003788 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 691437003789 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 691437003790 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 691437003791 IHF dimer interface [polypeptide binding]; other site 691437003792 IHF - DNA interface [nucleotide binding]; other site 691437003793 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 691437003794 homodecamer interface [polypeptide binding]; other site 691437003795 GTP cyclohydrolase I; Provisional; Region: PLN03044 691437003796 active site 691437003797 putative catalytic site residues [active] 691437003798 zinc binding site [ion binding]; other site 691437003799 GTP-CH-I/GFRP interaction surface; other site 691437003800 transcription attenuation protein MtrB; Provisional; Region: PRK13251 691437003801 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 691437003802 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 691437003803 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437003804 S-adenosylmethionine binding site [chemical binding]; other site 691437003805 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 691437003806 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 691437003807 substrate binding pocket [chemical binding]; other site 691437003808 chain length determination region; other site 691437003809 substrate-Mg2+ binding site; other site 691437003810 catalytic residues [active] 691437003811 aspartate-rich region 1; other site 691437003812 active site lid residues [active] 691437003813 aspartate-rich region 2; other site 691437003814 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 691437003815 active site 691437003816 multimer interface [polypeptide binding]; other site 691437003817 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 691437003818 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 691437003819 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437003820 S-adenosylmethionine binding site [chemical binding]; other site 691437003821 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 691437003822 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 691437003823 Tetramer interface [polypeptide binding]; other site 691437003824 active site 691437003825 FMN-binding site [chemical binding]; other site 691437003826 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 691437003827 active site 691437003828 dimer interface [polypeptide binding]; other site 691437003829 metal binding site [ion binding]; metal-binding site 691437003830 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 691437003831 homotrimer interaction site [polypeptide binding]; other site 691437003832 active site 691437003833 anthranilate synthase component I; Provisional; Region: PRK13569 691437003834 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 691437003835 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 691437003836 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 691437003837 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 691437003838 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 691437003839 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 691437003840 active site 691437003841 ribulose/triose binding site [chemical binding]; other site 691437003842 phosphate binding site [ion binding]; other site 691437003843 substrate (anthranilate) binding pocket [chemical binding]; other site 691437003844 product (indole) binding pocket [chemical binding]; other site 691437003845 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 691437003846 active site 691437003847 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 691437003848 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 691437003849 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437003850 catalytic residue [active] 691437003851 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 691437003852 substrate binding site [chemical binding]; other site 691437003853 active site 691437003854 catalytic residues [active] 691437003855 heterodimer interface [polypeptide binding]; other site 691437003856 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 691437003857 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 691437003858 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437003859 homodimer interface [polypeptide binding]; other site 691437003860 catalytic residue [active] 691437003861 prephenate dehydrogenase; Validated; Region: PRK06545 691437003862 prephenate dehydrogenase; Validated; Region: PRK08507 691437003863 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 691437003864 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 691437003865 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 691437003866 hinge; other site 691437003867 active site 691437003868 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 691437003869 binding surface 691437003870 TPR motif; other site 691437003871 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 691437003872 binding surface 691437003873 TPR motif; other site 691437003874 hypothetical protein; Provisional; Region: PRK03636 691437003875 UPF0302 domain; Region: UPF0302; pfam08864 691437003876 IDEAL domain; Region: IDEAL; pfam08858 691437003877 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 691437003878 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 691437003879 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 691437003880 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 691437003881 iron-sulfur cluster [ion binding]; other site 691437003882 [2Fe-2S] cluster binding site [ion binding]; other site 691437003883 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 691437003884 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 691437003885 interchain domain interface [polypeptide binding]; other site 691437003886 intrachain domain interface; other site 691437003887 heme bH binding site [chemical binding]; other site 691437003888 Qi binding site; other site 691437003889 heme bL binding site [chemical binding]; other site 691437003890 Qo binding site; other site 691437003891 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 691437003892 intrachain domain interface; other site 691437003893 Qi binding site; other site 691437003894 Qo binding site; other site 691437003895 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 691437003896 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 691437003897 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 691437003898 sporulation protein YpjB; Region: spore_ypjB; TIGR02878 691437003899 Uncharacterized conserved protein [Function unknown]; Region: COG1284 691437003900 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 691437003901 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 691437003902 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 691437003903 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 691437003904 homodimer interface [polypeptide binding]; other site 691437003905 metal binding site [ion binding]; metal-binding site 691437003906 dihydrodipicolinate reductase; Provisional; Region: PRK00048 691437003907 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 691437003908 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 691437003909 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 691437003910 active site 691437003911 dimer interfaces [polypeptide binding]; other site 691437003912 catalytic residues [active] 691437003913 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 691437003914 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 691437003915 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 691437003916 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 691437003917 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 691437003918 active site 691437003919 NTP binding site [chemical binding]; other site 691437003920 metal binding triad [ion binding]; metal-binding site 691437003921 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 691437003922 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 691437003923 Biotin operon repressor [Transcription]; Region: BirA; COG1654 691437003924 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 691437003925 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 691437003926 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 691437003927 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 691437003928 oligomerization interface [polypeptide binding]; other site 691437003929 active site 691437003930 metal binding site [ion binding]; metal-binding site 691437003931 pantoate--beta-alanine ligase; Region: panC; TIGR00018 691437003932 Pantoate-beta-alanine ligase; Region: PanC; cd00560 691437003933 active site 691437003934 ATP-binding site [chemical binding]; other site 691437003935 pantoate-binding site; other site 691437003936 HXXH motif; other site 691437003937 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 691437003938 tetramerization interface [polypeptide binding]; other site 691437003939 active site 691437003940 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 691437003941 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 691437003942 active site 691437003943 catalytic site [active] 691437003944 substrate binding site [chemical binding]; other site 691437003945 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 691437003946 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 691437003947 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 691437003948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 691437003949 aspartate aminotransferase; Provisional; Region: PRK05764 691437003950 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 691437003951 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437003952 homodimer interface [polypeptide binding]; other site 691437003953 catalytic residue [active] 691437003954 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 691437003955 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 691437003956 putative dimer interface [polypeptide binding]; other site 691437003957 putative anticodon binding site; other site 691437003958 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 691437003959 homodimer interface [polypeptide binding]; other site 691437003960 motif 1; other site 691437003961 motif 2; other site 691437003962 active site 691437003963 motif 3; other site 691437003964 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 691437003965 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 691437003966 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 691437003967 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 691437003968 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 691437003969 minor groove reading motif; other site 691437003970 helix-hairpin-helix signature motif; other site 691437003971 substrate binding pocket [chemical binding]; other site 691437003972 active site 691437003973 Transglycosylase; Region: Transgly; pfam00912 691437003974 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 691437003975 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 691437003976 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 691437003977 Interdomain contacts; other site 691437003978 Cytokine receptor motif; other site 691437003979 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 691437003980 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 691437003981 YppF-like protein; Region: YppF; pfam14178 691437003982 YppG-like protein; Region: YppG; pfam14179 691437003983 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 691437003984 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 691437003985 putative dimer interface [polypeptide binding]; other site 691437003986 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 691437003987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437003988 active site 691437003989 phosphorylation site [posttranslational modification] 691437003990 intermolecular recognition site; other site 691437003991 dimerization interface [polypeptide binding]; other site 691437003992 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 691437003993 DNA binding site [nucleotide binding] 691437003994 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 691437003995 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 691437003996 dimerization interface [polypeptide binding]; other site 691437003997 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437003998 dimer interface [polypeptide binding]; other site 691437003999 phosphorylation site [posttranslational modification] 691437004000 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437004001 ATP binding site [chemical binding]; other site 691437004002 Mg2+ binding site [ion binding]; other site 691437004003 G-X-G motif; other site 691437004004 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 691437004005 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 691437004006 EcsC protein family; Region: EcsC; pfam12787 691437004007 Predicted transcriptional regulator [Transcription]; Region: COG4189 691437004008 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 691437004009 dimerization interface [polypeptide binding]; other site 691437004010 putative DNA binding site [nucleotide binding]; other site 691437004011 putative Zn2+ binding site [ion binding]; other site 691437004012 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 691437004013 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 691437004014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437004015 dimer interface [polypeptide binding]; other site 691437004016 conserved gate region; other site 691437004017 putative PBP binding loops; other site 691437004018 ABC-ATPase subunit interface; other site 691437004019 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 691437004020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437004021 dimer interface [polypeptide binding]; other site 691437004022 conserved gate region; other site 691437004023 putative PBP binding loops; other site 691437004024 ABC-ATPase subunit interface; other site 691437004025 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 691437004026 putative substrate binding site [chemical binding]; other site 691437004027 active site 691437004028 Glycosyl hydrolase family 43; Region: GH43_2; cd08981 691437004029 active site 691437004030 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 691437004031 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 691437004032 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 691437004033 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 691437004034 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 691437004035 active site 691437004036 catalytic tetrad [active] 691437004037 galactokinase; Provisional; Region: PRK05322 691437004038 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 691437004039 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 691437004040 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 691437004041 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 691437004042 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 691437004043 NAD binding site [chemical binding]; other site 691437004044 homodimer interface [polypeptide binding]; other site 691437004045 active site 691437004046 substrate binding site [chemical binding]; other site 691437004047 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 691437004048 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 691437004049 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 691437004050 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 691437004051 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 691437004052 DNA binding site [nucleotide binding] 691437004053 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 691437004054 putative dimerization interface [polypeptide binding]; other site 691437004055 putative ligand binding site [chemical binding]; other site 691437004056 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 691437004057 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 691437004058 putative dimer interface [polypeptide binding]; other site 691437004059 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 691437004060 Transposase; Region: DEDD_Tnp_IS110; pfam01548 691437004061 LysE type translocator; Region: LysE; pfam01810 691437004062 Tetratricopeptide repeat; Region: TPR_12; pfam13424 691437004063 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 691437004064 binding surface 691437004065 TPR motif; other site 691437004066 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 691437004067 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 691437004068 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 691437004069 Na binding site [ion binding]; other site 691437004070 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 691437004071 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 691437004072 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 691437004073 acyl-activating enzyme (AAE) consensus motif; other site 691437004074 AMP binding site [chemical binding]; other site 691437004075 active site 691437004076 CoA binding site [chemical binding]; other site 691437004077 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 691437004078 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 691437004079 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 691437004080 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 691437004081 dimerization interface [polypeptide binding]; other site 691437004082 putative DNA binding site [nucleotide binding]; other site 691437004083 putative Zn2+ binding site [ion binding]; other site 691437004084 Predicted integral membrane protein [Function unknown]; Region: COG5658 691437004085 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 691437004086 SdpI/YhfL protein family; Region: SdpI; pfam13630 691437004087 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 691437004088 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 691437004089 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 691437004090 dimer interface [polypeptide binding]; other site 691437004091 putative metal binding site [ion binding]; other site 691437004092 acid-soluble spore protein H; Provisional; Region: sspH; PRK03174 691437004093 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 691437004094 putative active site [active] 691437004095 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 691437004096 putative active site [active] 691437004097 glutaminase; Provisional; Region: PRK00971 691437004098 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 691437004099 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 691437004100 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 691437004101 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 691437004102 Apolipophorin-III precursor (apoLp-III); Region: ApoLp-III; pfam07464 691437004103 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 691437004104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437004105 dimer interface [polypeptide binding]; other site 691437004106 conserved gate region; other site 691437004107 putative PBP binding loops; other site 691437004108 ABC-ATPase subunit interface; other site 691437004109 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 691437004110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437004111 dimer interface [polypeptide binding]; other site 691437004112 conserved gate region; other site 691437004113 putative PBP binding loops; other site 691437004114 ABC-ATPase subunit interface; other site 691437004115 MoaC_like Similar to the MaoC (monoamine oxidase C) dehydratase regulatory protein but without the N-terminal PutA domain. This protein family has a hot-dog fold similar to that of (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: MaoC_like; cd03446 691437004116 homodimer interaction site [polypeptide binding]; other site 691437004117 putative active site [active] 691437004118 putative catalytic site [active] 691437004119 metabolite-proton symporter; Region: 2A0106; TIGR00883 691437004120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437004121 putative substrate translocation pore; other site 691437004122 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 691437004123 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 691437004124 Coenzyme A binding pocket [chemical binding]; other site 691437004125 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 691437004126 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 691437004127 Transcriptional regulators [Transcription]; Region: PurR; COG1609 691437004128 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 691437004129 DNA binding site [nucleotide binding] 691437004130 domain linker motif; other site 691437004131 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 691437004132 dimerization interface [polypeptide binding]; other site 691437004133 ligand binding site [chemical binding]; other site 691437004134 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 691437004135 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 691437004136 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 691437004137 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 691437004138 conserved cys residue [active] 691437004139 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 691437004140 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 691437004141 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 691437004142 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 691437004143 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 691437004144 metal binding site [ion binding]; metal-binding site 691437004145 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b3; cd09205 691437004146 PLD-like domain; Region: PLDc_2; pfam13091 691437004147 putative homodimer interface [polypeptide binding]; other site 691437004148 putative active site [active] 691437004149 catalytic site [active] 691437004150 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 691437004151 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 691437004152 ATP binding site [chemical binding]; other site 691437004153 putative Mg++ binding site [ion binding]; other site 691437004154 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 691437004155 nucleotide binding region [chemical binding]; other site 691437004156 ATP-binding site [chemical binding]; other site 691437004157 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 691437004158 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909 691437004159 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 691437004160 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 691437004161 CRISPR-associated protein Cas5, subtype I-B/TNEAP; Region: cas_Cas5t; TIGR01895 691437004162 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 691437004163 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 691437004164 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 691437004165 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 691437004166 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 691437004167 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 691437004168 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 691437004169 Transposase [DNA replication, recombination, and repair]; Region: COG5421 691437004170 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 691437004171 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 691437004172 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 691437004173 active site 691437004174 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 691437004175 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 691437004176 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 691437004177 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 691437004178 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 691437004179 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 691437004180 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 691437004181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437004182 putative substrate translocation pore; other site 691437004183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437004184 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 691437004185 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 691437004186 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 691437004187 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 691437004188 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 691437004189 active site residue [active] 691437004190 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 691437004191 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 691437004192 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 691437004193 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 691437004194 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 691437004195 active site residue [active] 691437004196 PAS domain S-box; Region: sensory_box; TIGR00229 691437004197 PAS domain; Region: PAS_8; pfam13188 691437004198 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 691437004199 Histidine kinase; Region: HisKA_3; pfam07730 691437004200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437004201 ATP binding site [chemical binding]; other site 691437004202 Mg2+ binding site [ion binding]; other site 691437004203 G-X-G motif; other site 691437004204 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 691437004205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437004206 active site 691437004207 phosphorylation site [posttranslational modification] 691437004208 intermolecular recognition site; other site 691437004209 dimerization interface [polypeptide binding]; other site 691437004210 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 691437004211 DNA binding residues [nucleotide binding] 691437004212 dimerization interface [polypeptide binding]; other site 691437004213 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 691437004214 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 691437004215 Domain of unknown function (DUF202); Region: DUF202; pfam02656 691437004216 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 691437004217 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 691437004218 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 691437004219 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 691437004220 active site 691437004221 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 691437004222 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 691437004223 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 691437004224 active site residue [active] 691437004225 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 691437004226 Methyltransferase domain; Region: Methyltransf_31; pfam13847 691437004227 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437004228 S-adenosylmethionine binding site [chemical binding]; other site 691437004229 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 691437004230 active site residue [active] 691437004231 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 691437004232 putative homodimer interface [polypeptide binding]; other site 691437004233 putative homotetramer interface [polypeptide binding]; other site 691437004234 putative metal binding site [ion binding]; other site 691437004235 putative homodimer-homodimer interface [polypeptide binding]; other site 691437004236 putative allosteric switch controlling residues; other site 691437004237 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 691437004238 CPxP motif; other site 691437004239 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 691437004240 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 691437004241 active site residue [active] 691437004242 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 691437004243 active site residue [active] 691437004244 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 691437004245 CPxP motif; other site 691437004246 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 691437004247 active site residue [active] 691437004248 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 691437004249 active site residue [active] 691437004250 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 691437004251 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 691437004252 Domain of unknown function DUF302; Region: DUF302; cl01364 691437004253 CobD/Cbib protein; Region: CobD_Cbib; cl00561 691437004254 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 691437004255 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 691437004256 putative di-iron ligands [ion binding]; other site 691437004257 Predicted membrane protein [Function unknown]; Region: COG2510 691437004258 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 691437004259 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 691437004260 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 691437004261 active site 691437004262 motif I; other site 691437004263 motif II; other site 691437004264 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 691437004265 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 691437004266 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 691437004267 active site 691437004268 oxalacetate binding site [chemical binding]; other site 691437004269 citrylCoA binding site [chemical binding]; other site 691437004270 coenzyme A binding site [chemical binding]; other site 691437004271 catalytic triad [active] 691437004272 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 691437004273 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 691437004274 NAD(P) binding site [chemical binding]; other site 691437004275 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 691437004276 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 691437004277 PYR/PP interface [polypeptide binding]; other site 691437004278 dimer interface [polypeptide binding]; other site 691437004279 TPP binding site [chemical binding]; other site 691437004280 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 691437004281 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 691437004282 TPP-binding site [chemical binding]; other site 691437004283 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 691437004284 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 691437004285 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 691437004286 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 691437004287 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 691437004288 DctM-like transporters; Region: DctM; pfam06808 691437004289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437004290 D-galactonate transporter; Region: 2A0114; TIGR00893 691437004291 putative substrate translocation pore; other site 691437004292 Transcriptional regulator [Transcription]; Region: IclR; COG1414 691437004293 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 691437004294 Bacterial transcriptional regulator; Region: IclR; pfam01614 691437004295 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 691437004296 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 691437004297 active site 691437004298 catalytic residue [active] 691437004299 dimer interface [polypeptide binding]; other site 691437004300 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 691437004301 CoA-transferase family III; Region: CoA_transf_3; pfam02515 691437004302 Transcriptional regulators [Transcription]; Region: PurR; COG1609 691437004303 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 691437004304 DNA binding site [nucleotide binding] 691437004305 domain linker motif; other site 691437004306 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 691437004307 putative dimerization interface [polypeptide binding]; other site 691437004308 putative ligand binding site [chemical binding]; other site 691437004309 shikimate kinase; Reviewed; Region: aroK; PRK00131 691437004310 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 691437004311 ADP binding site [chemical binding]; other site 691437004312 magnesium binding site [ion binding]; other site 691437004313 putative shikimate binding site; other site 691437004314 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 691437004315 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 691437004316 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 691437004317 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 691437004318 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 691437004319 Ligand binding site; other site 691437004320 Putative Catalytic site; other site 691437004321 DXD motif; other site 691437004322 Predicted membrane protein [Function unknown]; Region: COG2246 691437004323 GtrA-like protein; Region: GtrA; pfam04138 691437004324 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 691437004325 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 691437004326 putative catalytic cysteine [active] 691437004327 gamma-glutamyl kinase; Provisional; Region: PRK05429 691437004328 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 691437004329 nucleotide binding site [chemical binding]; other site 691437004330 homotetrameric interface [polypeptide binding]; other site 691437004331 putative phosphate binding site [ion binding]; other site 691437004332 putative allosteric binding site; other site 691437004333 PUA domain; Region: PUA; pfam01472 691437004334 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 691437004335 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 691437004336 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 691437004337 acyl-activating enzyme (AAE) consensus motif; other site 691437004338 AMP binding site [chemical binding]; other site 691437004339 active site 691437004340 CoA binding site [chemical binding]; other site 691437004341 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 691437004342 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 691437004343 Phenylacetic acid degradation B; Region: PaaB; cl01371 691437004344 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 691437004345 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 691437004346 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 691437004347 conserved hypothetical protein; Region: TIGR02118 691437004348 enoyl-CoA hydratase; Provisional; Region: PRK05862 691437004349 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 691437004350 substrate binding site [chemical binding]; other site 691437004351 oxyanion hole (OAH) forming residues; other site 691437004352 trimer interface [polypeptide binding]; other site 691437004353 enoyl-CoA hydratase; Provisional; Region: PRK08140 691437004354 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 691437004355 substrate binding site [chemical binding]; other site 691437004356 oxyanion hole (OAH) forming residues; other site 691437004357 trimer interface [polypeptide binding]; other site 691437004358 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 691437004359 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 691437004360 NAD(P) binding site [chemical binding]; other site 691437004361 catalytic residues [active] 691437004362 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK09260 691437004363 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 691437004364 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 691437004365 putative acyltransferase; Provisional; Region: PRK05790 691437004366 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 691437004367 dimer interface [polypeptide binding]; other site 691437004368 active site 691437004369 PaaX-like protein; Region: PaaX; pfam07848 691437004370 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 691437004371 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 691437004372 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 691437004373 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 691437004374 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 691437004375 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437004376 putative substrate translocation pore; other site 691437004377 POT family; Region: PTR2; pfam00854 691437004378 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 691437004379 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 691437004380 Walker A/P-loop; other site 691437004381 ATP binding site [chemical binding]; other site 691437004382 Q-loop/lid; other site 691437004383 ABC transporter signature motif; other site 691437004384 Walker B; other site 691437004385 D-loop; other site 691437004386 H-loop/switch region; other site 691437004387 TOBE domain; Region: TOBE_2; pfam08402 691437004388 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 691437004389 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437004390 dimer interface [polypeptide binding]; other site 691437004391 conserved gate region; other site 691437004392 putative PBP binding loops; other site 691437004393 ABC-ATPase subunit interface; other site 691437004394 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 691437004395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437004396 dimer interface [polypeptide binding]; other site 691437004397 conserved gate region; other site 691437004398 putative PBP binding loops; other site 691437004399 ABC-ATPase subunit interface; other site 691437004400 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 691437004401 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 691437004402 Protein of unknown function (DUF1633); Region: DUF1633; pfam07794 691437004403 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 691437004404 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 691437004405 putative active site [active] 691437004406 putative metal binding site [ion binding]; other site 691437004407 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 691437004408 active site 691437004409 catalytic site [active] 691437004410 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 691437004411 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 691437004412 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 691437004413 NAD(P) binding site [chemical binding]; other site 691437004414 catalytic residues [active] 691437004415 PaaX-like protein; Region: PaaX; pfam07848 691437004416 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 691437004417 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 691437004418 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 691437004419 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 691437004420 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 691437004421 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 691437004422 Phenylacetic acid degradation B; Region: PaaB; cl01371 691437004423 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 691437004424 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 691437004425 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 691437004426 substrate binding site [chemical binding]; other site 691437004427 oxyanion hole (OAH) forming residues; other site 691437004428 trimer interface [polypeptide binding]; other site 691437004429 Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Region: BCL_4HBCL; cd05959 691437004430 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 691437004431 dimer interface [polypeptide binding]; other site 691437004432 acyl-activating enzyme (AAE) consensus motif; other site 691437004433 putative active site [active] 691437004434 putative AMP binding site [chemical binding]; other site 691437004435 putative CoA binding site [chemical binding]; other site 691437004436 chemical substrate binding site [chemical binding]; other site 691437004437 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 691437004438 active site 691437004439 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 691437004440 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 691437004441 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 691437004442 active site 691437004443 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 691437004444 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 691437004445 Sodium Bile acid symporter family; Region: SBF; cl17470 691437004446 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 691437004447 active site 691437004448 catalytic triad [active] 691437004449 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 691437004450 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 691437004451 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 691437004452 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 691437004453 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 691437004454 putative active site [active] 691437004455 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 691437004456 aromatic arch; other site 691437004457 DCoH dimer interaction site [polypeptide binding]; other site 691437004458 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 691437004459 DCoH tetramer interaction site [polypeptide binding]; other site 691437004460 substrate binding site [chemical binding]; other site 691437004461 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 691437004462 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437004463 NAD(P) binding site [chemical binding]; other site 691437004464 active site 691437004465 Uncharacterized conserved protein [Function unknown]; Region: COG2353 691437004466 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 691437004467 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 691437004468 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437004469 active site 691437004470 phosphorylation site [posttranslational modification] 691437004471 intermolecular recognition site; other site 691437004472 dimerization interface [polypeptide binding]; other site 691437004473 YcbB domain; Region: YcbB; pfam08664 691437004474 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 691437004475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437004476 ATP binding site [chemical binding]; other site 691437004477 G-X-G motif; other site 691437004478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437004479 dimer interface [polypeptide binding]; other site 691437004480 conserved gate region; other site 691437004481 putative PBP binding loops; other site 691437004482 ABC-ATPase subunit interface; other site 691437004483 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 691437004484 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437004485 dimer interface [polypeptide binding]; other site 691437004486 conserved gate region; other site 691437004487 putative PBP binding loops; other site 691437004488 ABC-ATPase subunit interface; other site 691437004489 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 691437004490 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 691437004491 substrate binding pocket [chemical binding]; other site 691437004492 membrane-bound complex binding site; other site 691437004493 hinge residues; other site 691437004494 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 691437004495 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 691437004496 Walker A/P-loop; other site 691437004497 ATP binding site [chemical binding]; other site 691437004498 Q-loop/lid; other site 691437004499 ABC transporter signature motif; other site 691437004500 Walker B; other site 691437004501 D-loop; other site 691437004502 H-loop/switch region; other site 691437004503 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 691437004504 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 691437004505 active site 691437004506 catalytic tetrad [active] 691437004507 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 691437004508 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 691437004509 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 691437004510 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 691437004511 DctM-like transporters; Region: DctM; pfam06808 691437004512 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 691437004513 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 691437004514 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 691437004515 Dehydratase family; Region: ILVD_EDD; cl00340 691437004516 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 691437004517 Transcriptional regulator [Transcription]; Region: IclR; COG1414 691437004518 Bacterial transcriptional regulator; Region: IclR; pfam01614 691437004519 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 691437004520 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 691437004521 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 691437004522 NAD(P) binding site [chemical binding]; other site 691437004523 catalytic residues [active] 691437004524 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 691437004525 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 691437004526 Ligand Binding Site [chemical binding]; other site 691437004527 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 691437004528 AIR carboxylase; Region: AIRC; smart01001 691437004529 hypothetical protein; Provisional; Region: PRK04194 691437004530 High-affinity nickel-transport protein; Region: NicO; cl00964 691437004531 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 691437004532 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 691437004533 inhibitor site; inhibition site 691437004534 active site 691437004535 dimer interface [polypeptide binding]; other site 691437004536 catalytic residue [active] 691437004537 Peptidase family U32; Region: Peptidase_U32; cl03113 691437004538 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 691437004539 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 691437004540 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 691437004541 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 691437004542 substrate binding site [chemical binding]; other site 691437004543 ATP binding site [chemical binding]; other site 691437004544 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 691437004545 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 691437004546 active site 691437004547 intersubunit interface [polypeptide binding]; other site 691437004548 catalytic residue [active] 691437004549 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 691437004550 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 691437004551 ligand binding site [chemical binding]; other site 691437004552 NAD binding site [chemical binding]; other site 691437004553 catalytic site [active] 691437004554 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 691437004555 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437004556 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 691437004557 Walker A motif; other site 691437004558 ATP binding site [chemical binding]; other site 691437004559 Walker B motif; other site 691437004560 arginine finger; other site 691437004561 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 691437004562 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 691437004563 active site 691437004564 NAD binding site [chemical binding]; other site 691437004565 metal binding site [ion binding]; metal-binding site 691437004566 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 691437004567 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 691437004568 tetrameric interface [polypeptide binding]; other site 691437004569 NAD binding site [chemical binding]; other site 691437004570 catalytic residues [active] 691437004571 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 691437004572 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 691437004573 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 691437004574 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 691437004575 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 691437004576 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 691437004577 active site 691437004578 P-loop; other site 691437004579 phosphorylation site [posttranslational modification] 691437004580 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 691437004581 HTH domain; Region: HTH_11; pfam08279 691437004582 PRD domain; Region: PRD; pfam00874 691437004583 PRD domain; Region: PRD; pfam00874 691437004584 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 691437004585 active site 691437004586 P-loop; other site 691437004587 phosphorylation site [posttranslational modification] 691437004588 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 691437004589 active site 691437004590 phosphorylation site [posttranslational modification] 691437004591 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 691437004592 active site 691437004593 phosphorylation site [posttranslational modification] 691437004594 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 691437004595 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 691437004596 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 691437004597 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 691437004598 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 691437004599 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 691437004600 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 691437004601 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 691437004602 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 691437004603 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 691437004604 putative active site [active] 691437004605 heme pocket [chemical binding]; other site 691437004606 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437004607 ATP binding site [chemical binding]; other site 691437004608 Mg2+ binding site [ion binding]; other site 691437004609 G-X-G motif; other site 691437004610 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 691437004611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437004612 active site 691437004613 phosphorylation site [posttranslational modification] 691437004614 intermolecular recognition site; other site 691437004615 dimerization interface [polypeptide binding]; other site 691437004616 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 691437004617 Predicted permeases [General function prediction only]; Region: COG0679 691437004618 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 691437004619 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 691437004620 Transcriptional regulators [Transcription]; Region: PurR; COG1609 691437004621 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 691437004622 DNA binding site [nucleotide binding] 691437004623 domain linker motif; other site 691437004624 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 691437004625 putative dimerization interface [polypeptide binding]; other site 691437004626 putative ligand binding site [chemical binding]; other site 691437004627 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 691437004628 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 691437004629 N- and C-terminal domain interface [polypeptide binding]; other site 691437004630 active site 691437004631 carbohydrate binding site [chemical binding]; other site 691437004632 ATP binding site [chemical binding]; other site 691437004633 fructuronate transporter; Provisional; Region: PRK10034; cl15264 691437004634 GntP family permease; Region: GntP_permease; pfam02447 691437004635 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 691437004636 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 691437004637 dimer interface [polypeptide binding]; other site 691437004638 putative CheW interface [polypeptide binding]; other site 691437004639 Cache domain; Region: Cache_1; pfam02743 691437004640 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 691437004641 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 691437004642 putative ligand binding site [chemical binding]; other site 691437004643 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 691437004644 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 691437004645 TM-ABC transporter signature motif; other site 691437004646 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 691437004647 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 691437004648 Walker A/P-loop; other site 691437004649 ATP binding site [chemical binding]; other site 691437004650 Q-loop/lid; other site 691437004651 ABC transporter signature motif; other site 691437004652 Walker B; other site 691437004653 D-loop; other site 691437004654 H-loop/switch region; other site 691437004655 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 691437004656 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 691437004657 Walker A/P-loop; other site 691437004658 ATP binding site [chemical binding]; other site 691437004659 Q-loop/lid; other site 691437004660 ABC transporter signature motif; other site 691437004661 Walker B; other site 691437004662 D-loop; other site 691437004663 H-loop/switch region; other site 691437004664 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 691437004665 alpha-gamma subunit interface [polypeptide binding]; other site 691437004666 beta-gamma subunit interface [polypeptide binding]; other site 691437004667 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 691437004668 gamma-beta subunit interface [polypeptide binding]; other site 691437004669 alpha-beta subunit interface [polypeptide binding]; other site 691437004670 urease subunit alpha; Reviewed; Region: ureC; PRK13207 691437004671 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 691437004672 subunit interactions [polypeptide binding]; other site 691437004673 active site 691437004674 flap region; other site 691437004675 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 691437004676 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 691437004677 dimer interface [polypeptide binding]; other site 691437004678 catalytic residues [active] 691437004679 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 691437004680 UreF; Region: UreF; pfam01730 691437004681 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 691437004682 UreD urease accessory protein; Region: UreD; cl00530 691437004683 High-affinity nickel-transport protein; Region: NicO; cl00964 691437004684 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 691437004685 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 691437004686 Coenzyme A binding pocket [chemical binding]; other site 691437004687 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437004688 Major Facilitator Superfamily; Region: MFS_1; pfam07690 691437004689 putative substrate translocation pore; other site 691437004690 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 691437004691 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 691437004692 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 691437004693 catalytic residue [active] 691437004694 Maltose acetyltransferase; Region: Mac; pfam12464 691437004695 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 691437004696 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 691437004697 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 691437004698 active site 691437004699 catalytic triad [active] 691437004700 dimer interface [polypeptide binding]; other site 691437004701 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 691437004702 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 691437004703 Na binding site [ion binding]; other site 691437004704 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 691437004705 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 691437004706 NAD(P) binding site [chemical binding]; other site 691437004707 catalytic residues [active] 691437004708 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 691437004709 agmatinase; Region: agmatinase; TIGR01230 691437004710 oligomer interface [polypeptide binding]; other site 691437004711 putative active site [active] 691437004712 Mn binding site [ion binding]; other site 691437004713 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 691437004714 PAS domain; Region: PAS_9; pfam13426 691437004715 putative active site [active] 691437004716 heme pocket [chemical binding]; other site 691437004717 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 691437004718 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437004719 Walker A motif; other site 691437004720 ATP binding site [chemical binding]; other site 691437004721 Walker B motif; other site 691437004722 arginine finger; other site 691437004723 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 691437004724 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 691437004725 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 691437004726 inhibitor-cofactor binding pocket; inhibition site 691437004727 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437004728 catalytic residue [active] 691437004729 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 691437004730 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 691437004731 inhibitor-cofactor binding pocket; inhibition site 691437004732 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437004733 catalytic residue [active] 691437004734 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 691437004735 Na binding site [ion binding]; other site 691437004736 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 691437004737 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 691437004738 NAD(P) binding site [chemical binding]; other site 691437004739 catalytic residues [active] 691437004740 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 691437004741 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 691437004742 enoyl-CoA hydratase; Provisional; Region: PRK07659 691437004743 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 691437004744 substrate binding site [chemical binding]; other site 691437004745 oxyanion hole (OAH) forming residues; other site 691437004746 trimer interface [polypeptide binding]; other site 691437004747 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 691437004748 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 691437004749 ligand binding site [chemical binding]; other site 691437004750 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 691437004751 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 691437004752 dimerization interface [polypeptide binding]; other site 691437004753 Histidine kinase; Region: His_kinase; pfam06580 691437004754 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437004755 ATP binding site [chemical binding]; other site 691437004756 Mg2+ binding site [ion binding]; other site 691437004757 G-X-G motif; other site 691437004758 Response regulator receiver domain; Region: Response_reg; pfam00072 691437004759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437004760 active site 691437004761 phosphorylation site [posttranslational modification] 691437004762 intermolecular recognition site; other site 691437004763 dimerization interface [polypeptide binding]; other site 691437004764 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 691437004765 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 691437004766 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 691437004767 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 691437004768 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 691437004769 putative ligand binding site [chemical binding]; other site 691437004770 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 691437004771 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 691437004772 Walker A/P-loop; other site 691437004773 ATP binding site [chemical binding]; other site 691437004774 Q-loop/lid; other site 691437004775 ABC transporter signature motif; other site 691437004776 Walker B; other site 691437004777 D-loop; other site 691437004778 H-loop/switch region; other site 691437004779 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 691437004780 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 691437004781 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 691437004782 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 691437004783 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 691437004784 TM-ABC transporter signature motif; other site 691437004785 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 691437004786 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 691437004787 DNA-binding site [nucleotide binding]; DNA binding site 691437004788 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 691437004789 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 691437004790 putative dimerization interface [polypeptide binding]; other site 691437004791 putative ligand binding site [chemical binding]; other site 691437004792 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 691437004793 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 691437004794 intersubunit interface [polypeptide binding]; other site 691437004795 active site 691437004796 Zn2+ binding site [ion binding]; other site 691437004797 ribulokinase; Provisional; Region: PRK04123 691437004798 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 691437004799 N- and C-terminal domain interface [polypeptide binding]; other site 691437004800 active site 691437004801 MgATP binding site [chemical binding]; other site 691437004802 catalytic site [active] 691437004803 metal binding site [ion binding]; metal-binding site 691437004804 carbohydrate binding site [chemical binding]; other site 691437004805 homodimer interface [polypeptide binding]; other site 691437004806 L-arabinose isomerase; Provisional; Region: PRK02929 691437004807 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 691437004808 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 691437004809 trimer interface [polypeptide binding]; other site 691437004810 putative substrate binding site [chemical binding]; other site 691437004811 putative metal binding site [ion binding]; other site 691437004812 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 691437004813 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 691437004814 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437004815 dimer interface [polypeptide binding]; other site 691437004816 conserved gate region; other site 691437004817 putative PBP binding loops; other site 691437004818 ABC-ATPase subunit interface; other site 691437004819 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 691437004820 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437004821 dimer interface [polypeptide binding]; other site 691437004822 conserved gate region; other site 691437004823 putative PBP binding loops; other site 691437004824 ABC-ATPase subunit interface; other site 691437004825 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 691437004826 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 691437004827 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 691437004828 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 691437004829 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 691437004830 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 691437004831 active site 691437004832 catalytic residues [active] 691437004833 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 691437004834 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 691437004835 active site 691437004836 motif I; other site 691437004837 motif II; other site 691437004838 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 691437004839 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 691437004840 active site 691437004841 metal binding site [ion binding]; metal-binding site 691437004842 Probable transposase; Region: OrfB_IS605; pfam01385 691437004843 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 691437004844 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 691437004845 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 691437004846 HAMP domain; Region: HAMP; pfam00672 691437004847 Histidine kinase; Region: His_kinase; pfam06580 691437004848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437004849 ATP binding site [chemical binding]; other site 691437004850 Mg2+ binding site [ion binding]; other site 691437004851 G-X-G motif; other site 691437004852 Response regulator receiver domain; Region: Response_reg; pfam00072 691437004853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437004854 active site 691437004855 phosphorylation site [posttranslational modification] 691437004856 intermolecular recognition site; other site 691437004857 dimerization interface [polypeptide binding]; other site 691437004858 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 691437004859 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 691437004860 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 691437004861 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 691437004862 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 691437004863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437004864 dimer interface [polypeptide binding]; other site 691437004865 putative PBP binding loops; other site 691437004866 ABC-ATPase subunit interface; other site 691437004867 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 691437004868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437004869 dimer interface [polypeptide binding]; other site 691437004870 conserved gate region; other site 691437004871 putative PBP binding loops; other site 691437004872 ABC-ATPase subunit interface; other site 691437004873 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 691437004874 active site 691437004875 catalytic residues [active] 691437004876 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 691437004877 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 691437004878 NodB motif; other site 691437004879 active site 691437004880 catalytic site [active] 691437004881 metal binding site [ion binding]; metal-binding site 691437004882 Glycosyl hydrolase family 52; Region: Glyco_hydro_52; pfam03512 691437004883 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 691437004884 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 691437004885 D-aminoacylase, C-terminal region; Region: D-aminoacyl_C; pfam07908 691437004886 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 691437004887 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437004888 dimer interface [polypeptide binding]; other site 691437004889 conserved gate region; other site 691437004890 putative PBP binding loops; other site 691437004891 ABC-ATPase subunit interface; other site 691437004892 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 691437004893 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437004894 dimer interface [polypeptide binding]; other site 691437004895 ABC-ATPase subunit interface; other site 691437004896 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 691437004897 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 691437004898 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 691437004899 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 691437004900 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 691437004901 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 691437004902 substrate binding site [chemical binding]; other site 691437004903 ATP binding site [chemical binding]; other site 691437004904 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 691437004905 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 691437004906 active site 691437004907 intersubunit interface [polypeptide binding]; other site 691437004908 catalytic residue [active] 691437004909 Transcriptional regulators [Transcription]; Region: GntR; COG1802 691437004910 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 691437004911 DNA-binding site [nucleotide binding]; DNA binding site 691437004912 FCD domain; Region: FCD; pfam07729 691437004913 Glucuronate isomerase; Region: UxaC; pfam02614 691437004914 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 691437004915 mannonate dehydratase; Provisional; Region: PRK03906 691437004916 mannonate dehydratase; Region: uxuA; TIGR00695 691437004917 D-mannonate oxidoreductase; Provisional; Region: PRK08277 691437004918 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437004919 NAD(P) binding site [chemical binding]; other site 691437004920 active site 691437004921 Predicted integral membrane protein [Function unknown]; Region: COG5578 691437004922 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 691437004923 Uncharacterized conserved protein [Function unknown]; Region: COG0327 691437004924 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 691437004925 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 691437004926 active site 691437004927 catalytic triad [active] 691437004928 oxyanion hole [active] 691437004929 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 691437004930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437004931 active site 691437004932 phosphorylation site [posttranslational modification] 691437004933 intermolecular recognition site; other site 691437004934 dimerization interface [polypeptide binding]; other site 691437004935 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 691437004936 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 691437004937 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 691437004938 HAMP domain; Region: HAMP; pfam00672 691437004939 dimerization interface [polypeptide binding]; other site 691437004940 Histidine kinase; Region: His_kinase; pfam06580 691437004941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437004942 Mg2+ binding site [ion binding]; other site 691437004943 G-X-G motif; other site 691437004944 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 691437004945 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 691437004946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437004947 dimer interface [polypeptide binding]; other site 691437004948 conserved gate region; other site 691437004949 putative PBP binding loops; other site 691437004950 ABC-ATPase subunit interface; other site 691437004951 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 691437004952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437004953 dimer interface [polypeptide binding]; other site 691437004954 conserved gate region; other site 691437004955 ABC-ATPase subunit interface; other site 691437004956 xylose isomerase; Provisional; Region: PRK05474 691437004957 xylose isomerase; Region: xylose_isom_A; TIGR02630 691437004958 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 691437004959 N- and C-terminal domain interface [polypeptide binding]; other site 691437004960 D-xylulose kinase; Region: XylB; TIGR01312 691437004961 active site 691437004962 MgATP binding site [chemical binding]; other site 691437004963 catalytic site [active] 691437004964 metal binding site [ion binding]; metal-binding site 691437004965 xylulose binding site [chemical binding]; other site 691437004966 homodimer interface [polypeptide binding]; other site 691437004967 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 691437004968 Nitronate monooxygenase; Region: NMO; pfam03060 691437004969 FMN binding site [chemical binding]; other site 691437004970 substrate binding site [chemical binding]; other site 691437004971 putative catalytic residue [active] 691437004972 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 691437004973 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 691437004974 putative active site [active] 691437004975 heme pocket [chemical binding]; other site 691437004976 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 691437004977 putative active site [active] 691437004978 heme pocket [chemical binding]; other site 691437004979 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437004980 Walker A motif; other site 691437004981 ATP binding site [chemical binding]; other site 691437004982 Walker B motif; other site 691437004983 arginine finger; other site 691437004984 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 691437004985 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 691437004986 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 691437004987 putative active site [active] 691437004988 metal binding site [ion binding]; metal-binding site 691437004989 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 691437004990 active site 691437004991 DnaA N-terminal domain; Region: DnaA_N; pfam11638 691437004992 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 691437004993 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 691437004994 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 691437004995 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 691437004996 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 691437004997 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 691437004998 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 691437004999 [2Fe-2S] cluster binding site [ion binding]; other site 691437005000 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 691437005001 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 691437005002 [4Fe-4S] binding site [ion binding]; other site 691437005003 molybdopterin cofactor binding site; other site 691437005004 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 691437005005 molybdopterin cofactor binding site; other site 691437005006 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 691437005007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437005008 putative substrate translocation pore; other site 691437005009 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 691437005010 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 691437005011 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 691437005012 DNA binding residues [nucleotide binding] 691437005013 putative dimer interface [polypeptide binding]; other site 691437005014 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 691437005015 active site 691437005016 P-loop; other site 691437005017 phosphorylation site [posttranslational modification] 691437005018 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 691437005019 active site 691437005020 methionine cluster; other site 691437005021 phosphorylation site [posttranslational modification] 691437005022 metal binding site [ion binding]; metal-binding site 691437005023 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 691437005024 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 691437005025 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 691437005026 beta-galactosidase; Region: BGL; TIGR03356 691437005027 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 691437005028 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 691437005029 DNA-binding site [nucleotide binding]; DNA binding site 691437005030 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 691437005031 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 691437005032 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 691437005033 putative active site [active] 691437005034 putative metal binding site [ion binding]; other site 691437005035 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 691437005036 Endonuclease I; Region: Endonuclease_1; pfam04231 691437005037 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 691437005038 Sodium Bile acid symporter family; Region: SBF; pfam01758 691437005039 FeoA domain; Region: FeoA; pfam04023 691437005040 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 691437005041 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 691437005042 G1 box; other site 691437005043 GTP/Mg2+ binding site [chemical binding]; other site 691437005044 Switch I region; other site 691437005045 G2 box; other site 691437005046 G3 box; other site 691437005047 Switch II region; other site 691437005048 G4 box; other site 691437005049 G5 box; other site 691437005050 Nucleoside recognition; Region: Gate; pfam07670 691437005051 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 691437005052 Nucleoside recognition; Region: Gate; pfam07670 691437005053 Fic/DOC family; Region: Fic; cl00960 691437005054 putative addiction module antidote; Region: doc_partner; TIGR02609 691437005055 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 691437005056 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 691437005057 metal binding site [ion binding]; metal-binding site 691437005058 active site 691437005059 I-site; other site 691437005060 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 691437005061 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 691437005062 Zn2+ binding site [ion binding]; other site 691437005063 Mg2+ binding site [ion binding]; other site 691437005064 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 691437005065 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 691437005066 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 691437005067 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 691437005068 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 691437005069 putative substrate binding site [chemical binding]; other site 691437005070 putative ATP binding site [chemical binding]; other site 691437005071 Trp repressor protein; Region: Trp_repressor; cl17266 691437005072 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 691437005073 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 691437005074 active site 691437005075 phosphorylation site [posttranslational modification] 691437005076 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 691437005077 active site 691437005078 P-loop; other site 691437005079 phosphorylation site [posttranslational modification] 691437005080 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 691437005081 Predicted permeases [General function prediction only]; Region: COG0701 691437005082 Predicted membrane protein [Function unknown]; Region: COG3689 691437005083 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 691437005084 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 691437005085 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 691437005086 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 691437005087 active site 691437005088 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437005089 dimer interface [polypeptide binding]; other site 691437005090 phosphorylation site [posttranslational modification] 691437005091 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437005092 ATP binding site [chemical binding]; other site 691437005093 Mg2+ binding site [ion binding]; other site 691437005094 G-X-G motif; other site 691437005095 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 691437005096 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 691437005097 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 691437005098 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 691437005099 active site 691437005100 Hemerythrin-like domain; Region: Hr-like; cd12108 691437005101 Fe binding site [ion binding]; other site 691437005102 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 691437005103 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 691437005104 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 691437005105 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 691437005106 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 691437005107 [4Fe-4S] binding site [ion binding]; other site 691437005108 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 691437005109 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 691437005110 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 691437005111 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 691437005112 molybdopterin cofactor binding site; other site 691437005113 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 691437005114 Esterase/lipase [General function prediction only]; Region: COG1647 691437005115 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 691437005116 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 691437005117 putative active site [active] 691437005118 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 691437005119 TPR motif; other site 691437005120 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 691437005121 binding surface 691437005122 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 691437005123 binding surface 691437005124 TPR motif; other site 691437005125 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 691437005126 binding surface 691437005127 TPR motif; other site 691437005128 Tetratricopeptide repeat; Region: TPR_12; pfam13424 691437005129 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 691437005130 TPR motif; other site 691437005131 binding surface 691437005132 TPR repeat; Region: TPR_11; pfam13414 691437005133 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 691437005134 TPR motif; other site 691437005135 binding surface 691437005136 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 691437005137 TPR motif; other site 691437005138 binding surface 691437005139 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 691437005140 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 691437005141 Isochorismatase family; Region: Isochorismatase; pfam00857 691437005142 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 691437005143 catalytic triad [active] 691437005144 conserved cis-peptide bond; other site 691437005145 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 691437005146 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 691437005147 active site 691437005148 oligoendopeptidase F; Region: pepF; TIGR00181 691437005149 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 691437005150 active site 691437005151 Zn binding site [ion binding]; other site 691437005152 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 691437005153 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 691437005154 active site 691437005155 catalytic tetrad [active] 691437005156 DNA topoisomerase III; Provisional; Region: PRK07726 691437005157 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 691437005158 active site 691437005159 putative interdomain interaction site [polypeptide binding]; other site 691437005160 putative metal-binding site [ion binding]; other site 691437005161 putative nucleotide binding site [chemical binding]; other site 691437005162 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 691437005163 domain I; other site 691437005164 DNA binding groove [nucleotide binding] 691437005165 phosphate binding site [ion binding]; other site 691437005166 domain II; other site 691437005167 domain III; other site 691437005168 nucleotide binding site [chemical binding]; other site 691437005169 catalytic site [active] 691437005170 domain IV; other site 691437005171 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 691437005172 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 691437005173 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 691437005174 active site 691437005175 catalytic site [active] 691437005176 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 691437005177 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 691437005178 inhibitor binding site; inhibition site 691437005179 catalytic motif [active] 691437005180 Catalytic residue [active] 691437005181 Active site flap [active] 691437005182 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 691437005183 dimer interface [polypeptide binding]; other site 691437005184 [2Fe-2S] cluster binding site [ion binding]; other site 691437005185 cobalt transport protein CbiM; Validated; Region: PRK08319 691437005186 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 691437005187 cobalt transport protein CbiN; Provisional; Region: PRK02898 691437005188 Cobalt transport protein; Region: CbiQ; cl00463 691437005189 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 691437005190 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 691437005191 Walker A/P-loop; other site 691437005192 ATP binding site [chemical binding]; other site 691437005193 Q-loop/lid; other site 691437005194 ABC transporter signature motif; other site 691437005195 Walker B; other site 691437005196 D-loop; other site 691437005197 H-loop/switch region; other site 691437005198 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 691437005199 active site 691437005200 SAM binding site [chemical binding]; other site 691437005201 homodimer interface [polypeptide binding]; other site 691437005202 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 691437005203 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 691437005204 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 691437005205 putative active site [active] 691437005206 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 691437005207 putative active site [active] 691437005208 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 691437005209 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 691437005210 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 691437005211 Precorrin-8X methylmutase; Region: CbiC; pfam02570 691437005212 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 691437005213 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 691437005214 active site 691437005215 putative homodimer interface [polypeptide binding]; other site 691437005216 SAM binding site [chemical binding]; other site 691437005217 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 691437005218 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437005219 S-adenosylmethionine binding site [chemical binding]; other site 691437005220 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 691437005221 active site 691437005222 SAM binding site [chemical binding]; other site 691437005223 homodimer interface [polypeptide binding]; other site 691437005224 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 691437005225 active site 691437005226 SAM binding site [chemical binding]; other site 691437005227 homodimer interface [polypeptide binding]; other site 691437005228 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 691437005229 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 691437005230 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 691437005231 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 691437005232 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 691437005233 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 691437005234 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 691437005235 catalytic triad [active] 691437005236 cobyric acid synthase; Provisional; Region: PRK00784 691437005237 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 691437005238 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 691437005239 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 691437005240 catalytic triad [active] 691437005241 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 691437005242 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 691437005243 putative dimer interface [polypeptide binding]; other site 691437005244 active site pocket [active] 691437005245 putative cataytic base [active] 691437005246 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 691437005247 active site 691437005248 SAM binding site [chemical binding]; other site 691437005249 homodimer interface [polypeptide binding]; other site 691437005250 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 691437005251 Homoserine O-succinyltransferase; Region: HTS; pfam04204 691437005252 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 691437005253 proposed active site lysine [active] 691437005254 conserved cys residue [active] 691437005255 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 691437005256 catalytic residues [active] 691437005257 dimer interface [polypeptide binding]; other site 691437005258 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 691437005259 Virulence factor; Region: Virulence_fact; pfam13769 691437005260 HEAT repeats; Region: HEAT_2; pfam13646 691437005261 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 691437005262 HEAT repeats; Region: HEAT_2; pfam13646 691437005263 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 691437005264 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 691437005265 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 691437005266 Disulphide isomerase; Region: Disulph_isomer; pfam06491 691437005267 YuzL-like protein; Region: YuzL; pfam14115 691437005268 aspartate aminotransferase; Provisional; Region: PRK07681 691437005269 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 691437005270 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437005271 homodimer interface [polypeptide binding]; other site 691437005272 catalytic residue [active] 691437005273 YpjP-like protein; Region: YpjP; pfam14005 691437005274 thymidylate synthase; Reviewed; Region: thyA; PRK01827 691437005275 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 691437005276 dimerization interface [polypeptide binding]; other site 691437005277 active site 691437005278 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 691437005279 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 691437005280 folate binding site [chemical binding]; other site 691437005281 NADP+ binding site [chemical binding]; other site 691437005282 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 691437005283 threonine dehydratase; Validated; Region: PRK08639 691437005284 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 691437005285 tetramer interface [polypeptide binding]; other site 691437005286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437005287 catalytic residue [active] 691437005288 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 691437005289 putative Ile/Val binding site [chemical binding]; other site 691437005290 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 691437005291 EDD domain protein, DegV family; Region: DegV; TIGR00762 691437005292 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 691437005293 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 691437005294 Cu(I) binding site [ion binding]; other site 691437005295 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 691437005296 active site 691437005297 catalytic triad [active] 691437005298 oxyanion hole [active] 691437005299 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 691437005300 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 691437005301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437005302 S-adenosylmethionine binding site [chemical binding]; other site 691437005303 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 691437005304 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 691437005305 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 691437005306 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 691437005307 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 691437005308 putative active site [active] 691437005309 putative metal binding site [ion binding]; other site 691437005310 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 691437005311 peptidase T; Region: peptidase-T; TIGR01882 691437005312 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 691437005313 metal binding site [ion binding]; metal-binding site 691437005314 dimer interface [polypeptide binding]; other site 691437005315 threonine synthase; Validated; Region: PRK08197 691437005316 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 691437005317 homodimer interface [polypeptide binding]; other site 691437005318 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437005319 catalytic residue [active] 691437005320 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 691437005321 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 691437005322 Moco binding site; other site 691437005323 metal coordination site [ion binding]; other site 691437005324 Protein of unknown function (DUF969); Region: DUF969; pfam06149 691437005325 Predicted membrane protein [Function unknown]; Region: COG3817 691437005326 Protein of unknown function (DUF979); Region: DUF979; pfam06166 691437005327 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 691437005328 putative substrate binding pocket [chemical binding]; other site 691437005329 AC domain interface; other site 691437005330 catalytic triad [active] 691437005331 AB domain interface; other site 691437005332 interchain disulfide; other site 691437005333 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 691437005334 Uncharacterized conserved protein [Function unknown]; Region: COG3937 691437005335 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 691437005336 ABC1 family; Region: ABC1; pfam03109 691437005337 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 691437005338 active site 691437005339 ATP binding site [chemical binding]; other site 691437005340 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 691437005341 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 691437005342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437005343 ATP binding site [chemical binding]; other site 691437005344 Mg2+ binding site [ion binding]; other site 691437005345 G-X-G motif; other site 691437005346 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 691437005347 anchoring element; other site 691437005348 dimer interface [polypeptide binding]; other site 691437005349 ATP binding site [chemical binding]; other site 691437005350 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 691437005351 active site 691437005352 putative metal-binding site [ion binding]; other site 691437005353 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 691437005354 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 691437005355 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 691437005356 CAP-like domain; other site 691437005357 active site 691437005358 primary dimer interface [polypeptide binding]; other site 691437005359 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 691437005360 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 691437005361 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 691437005362 PilZ domain; Region: PilZ; pfam07238 691437005363 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 691437005364 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg1; cd04764 691437005365 DNA binding residues [nucleotide binding] 691437005366 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 691437005367 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 691437005368 active site turn [active] 691437005369 phosphorylation site [posttranslational modification] 691437005370 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 691437005371 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 691437005372 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 691437005373 Ca binding site [ion binding]; other site 691437005374 active site 691437005375 catalytic site [active] 691437005376 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 691437005377 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 691437005378 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 691437005379 DNA-binding site [nucleotide binding]; DNA binding site 691437005380 UTRA domain; Region: UTRA; pfam07702 691437005381 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 691437005382 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 691437005383 active site 691437005384 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 691437005385 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 691437005386 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 691437005387 catalytic residue [active] 691437005388 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 691437005389 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 691437005390 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 691437005391 spermidine synthase; Provisional; Region: PRK00811 691437005392 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437005393 S-adenosylmethionine binding site [chemical binding]; other site 691437005394 Transcriptional regulator; Region: Rrf2; cl17282 691437005395 Predicted transcriptional regulator [Transcription]; Region: COG1959 691437005396 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 691437005397 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 691437005398 heme-binding site [chemical binding]; other site 691437005399 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 691437005400 FAD binding pocket [chemical binding]; other site 691437005401 FAD binding motif [chemical binding]; other site 691437005402 phosphate binding motif [ion binding]; other site 691437005403 beta-alpha-beta structure motif; other site 691437005404 NAD binding pocket [chemical binding]; other site 691437005405 Heme binding pocket [chemical binding]; other site 691437005406 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 691437005407 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 691437005408 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 691437005409 putative active site [active] 691437005410 putative substrate binding site [chemical binding]; other site 691437005411 putative cosubstrate binding site; other site 691437005412 catalytic site [active] 691437005413 Replication terminator protein; Region: RTP; pfam02334 691437005414 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437005415 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 691437005416 Walker A motif; other site 691437005417 ATP binding site [chemical binding]; other site 691437005418 Walker B motif; other site 691437005419 arginine finger; other site 691437005420 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 691437005421 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 691437005422 metal ion-dependent adhesion site (MIDAS); other site 691437005423 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 691437005424 DHH family; Region: DHH; pfam01368 691437005425 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 691437005426 Peptidase family M23; Region: Peptidase_M23; pfam01551 691437005427 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 691437005428 nudix motif; other site 691437005429 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 691437005430 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 691437005431 dimer interface [polypeptide binding]; other site 691437005432 active site 691437005433 heme binding site [chemical binding]; other site 691437005434 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 691437005435 H+ Antiporter protein; Region: 2A0121; TIGR00900 691437005436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437005437 putative substrate translocation pore; other site 691437005438 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 691437005439 LysE type translocator; Region: LysE; cl00565 691437005440 Predicted membrane protein [Function unknown]; Region: COG3428 691437005441 Bacterial PH domain; Region: DUF304; pfam03703 691437005442 Bacterial PH domain; Region: DUF304; pfam03703 691437005443 Bacterial PH domain; Region: DUF304; pfam03703 691437005444 Uncharacterized conserved protein [Function unknown]; Region: COG3402 691437005445 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 691437005446 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 691437005447 Uncharacterized conserved protein [Function unknown]; Region: COG0398 691437005448 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 691437005449 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 691437005450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437005451 active site 691437005452 phosphorylation site [posttranslational modification] 691437005453 intermolecular recognition site; other site 691437005454 dimerization interface [polypeptide binding]; other site 691437005455 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 691437005456 DNA binding site [nucleotide binding] 691437005457 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 691437005458 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 691437005459 dimerization interface [polypeptide binding]; other site 691437005460 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437005461 dimer interface [polypeptide binding]; other site 691437005462 phosphorylation site [posttranslational modification] 691437005463 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437005464 ATP binding site [chemical binding]; other site 691437005465 Mg2+ binding site [ion binding]; other site 691437005466 G-X-G motif; other site 691437005467 DNA topoisomerase III; Provisional; Region: PRK07726 691437005468 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 691437005469 active site 691437005470 putative interdomain interaction site [polypeptide binding]; other site 691437005471 putative metal-binding site [ion binding]; other site 691437005472 putative nucleotide binding site [chemical binding]; other site 691437005473 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 691437005474 domain I; other site 691437005475 DNA binding groove [nucleotide binding] 691437005476 phosphate binding site [ion binding]; other site 691437005477 domain II; other site 691437005478 domain III; other site 691437005479 nucleotide binding site [chemical binding]; other site 691437005480 catalytic site [active] 691437005481 domain IV; other site 691437005482 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 691437005483 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 691437005484 Catalytic domain of Protein Kinases; Region: PKc; cd00180 691437005485 active site 691437005486 ATP binding site [chemical binding]; other site 691437005487 substrate binding site [chemical binding]; other site 691437005488 activation loop (A-loop); other site 691437005489 enoyl-CoA hydratase; Provisional; Region: PRK06688 691437005490 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 691437005491 substrate binding site [chemical binding]; other site 691437005492 oxyanion hole (OAH) forming residues; other site 691437005493 trimer interface [polypeptide binding]; other site 691437005494 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 691437005495 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437005496 NAD(P) binding site [chemical binding]; other site 691437005497 active site 691437005498 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 691437005499 classical (c) SDRs; Region: SDR_c; cd05233 691437005500 NAD(P) binding site [chemical binding]; other site 691437005501 active site 691437005502 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 691437005503 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 691437005504 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 691437005505 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 691437005506 Walker A/P-loop; other site 691437005507 ATP binding site [chemical binding]; other site 691437005508 Q-loop/lid; other site 691437005509 ABC transporter signature motif; other site 691437005510 Walker B; other site 691437005511 D-loop; other site 691437005512 H-loop/switch region; other site 691437005513 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 691437005514 active site 691437005515 dimer interface [polypeptide binding]; other site 691437005516 Predicted membrane protein [Function unknown]; Region: COG1511 691437005517 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 691437005518 Predicted membrane protein [Function unknown]; Region: COG1511 691437005519 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 691437005520 Protein of unknown function, DUF606; Region: DUF606; pfam04657 691437005521 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 691437005522 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 691437005523 Chromate transporter; Region: Chromate_transp; pfam02417 691437005524 QueT transporter; Region: QueT; pfam06177 691437005525 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 691437005526 OsmC-like protein; Region: OsmC; pfam02566 691437005527 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 691437005528 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336 691437005529 putative ligand binding site [chemical binding]; other site 691437005530 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 691437005531 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 691437005532 Walker A/P-loop; other site 691437005533 ATP binding site [chemical binding]; other site 691437005534 Q-loop/lid; other site 691437005535 ABC transporter signature motif; other site 691437005536 Walker B; other site 691437005537 D-loop; other site 691437005538 H-loop/switch region; other site 691437005539 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 691437005540 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 691437005541 Walker A/P-loop; other site 691437005542 ATP binding site [chemical binding]; other site 691437005543 Q-loop/lid; other site 691437005544 ABC transporter signature motif; other site 691437005545 Walker B; other site 691437005546 D-loop; other site 691437005547 H-loop/switch region; other site 691437005548 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 691437005549 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 691437005550 TM-ABC transporter signature motif; other site 691437005551 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 691437005552 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 691437005553 TM-ABC transporter signature motif; other site 691437005554 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 691437005555 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 691437005556 putative acyltransferase; Provisional; Region: PRK05790 691437005557 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 691437005558 dimer interface [polypeptide binding]; other site 691437005559 active site 691437005560 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 691437005561 active site 691437005562 catalytic site [active] 691437005563 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 691437005564 active site 691437005565 catalytic site [active] 691437005566 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 691437005567 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437005568 NAD(P) binding site [chemical binding]; other site 691437005569 active site 691437005570 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 691437005571 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 691437005572 active site 691437005573 NAD-dependent deacetylase; Provisional; Region: PRK00481 691437005574 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 691437005575 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 691437005576 dimer interface [polypeptide binding]; other site 691437005577 FMN binding site [chemical binding]; other site 691437005578 NADPH bind site [chemical binding]; other site 691437005579 Pirin-related protein [General function prediction only]; Region: COG1741 691437005580 Pirin; Region: Pirin; pfam02678 691437005581 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 691437005582 PemK-like protein; Region: PemK; cl00995 691437005583 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 691437005584 Probable transposase; Region: OrfB_IS605; pfam01385 691437005585 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 691437005586 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 691437005587 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 691437005588 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 691437005589 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 691437005590 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 691437005591 Walker A/P-loop; other site 691437005592 ATP binding site [chemical binding]; other site 691437005593 Q-loop/lid; other site 691437005594 ABC transporter signature motif; other site 691437005595 Walker B; other site 691437005596 D-loop; other site 691437005597 H-loop/switch region; other site 691437005598 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 691437005599 active site 691437005600 catalytic triad [active] 691437005601 oxyanion hole [active] 691437005602 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 691437005603 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 691437005604 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 691437005605 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 691437005606 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 691437005607 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 691437005608 putative active site pocket [active] 691437005609 dimerization interface [polypeptide binding]; other site 691437005610 putative catalytic residue [active] 691437005611 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 691437005612 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 691437005613 putative catalytic residue [active] 691437005614 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 691437005615 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 691437005616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 691437005617 MOSC domain; Region: MOSC; pfam03473 691437005618 3-alpha domain; Region: 3-alpha; pfam03475 691437005619 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 691437005620 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 691437005621 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 691437005622 Walker A/P-loop; other site 691437005623 ATP binding site [chemical binding]; other site 691437005624 Q-loop/lid; other site 691437005625 ABC transporter signature motif; other site 691437005626 Walker B; other site 691437005627 D-loop; other site 691437005628 H-loop/switch region; other site 691437005629 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 691437005630 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 691437005631 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 691437005632 Walker A/P-loop; other site 691437005633 ATP binding site [chemical binding]; other site 691437005634 Q-loop/lid; other site 691437005635 ABC transporter signature motif; other site 691437005636 Walker B; other site 691437005637 D-loop; other site 691437005638 H-loop/switch region; other site 691437005639 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 691437005640 anti sigma factor interaction site; other site 691437005641 regulatory phosphorylation site [posttranslational modification]; other site 691437005642 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 691437005643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 691437005644 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 691437005645 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 691437005646 putative active site [active] 691437005647 heme pocket [chemical binding]; other site 691437005648 PAS domain; Region: PAS; smart00091 691437005649 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 691437005650 Spore germination protein; Region: Spore_permease; pfam03845 691437005651 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 691437005652 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 691437005653 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 691437005654 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 691437005655 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 691437005656 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 691437005657 Walker A/P-loop; other site 691437005658 ATP binding site [chemical binding]; other site 691437005659 Q-loop/lid; other site 691437005660 ABC transporter signature motif; other site 691437005661 Walker B; other site 691437005662 D-loop; other site 691437005663 H-loop/switch region; other site 691437005664 Predicted transcriptional regulators [Transcription]; Region: COG1725 691437005665 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 691437005666 DNA-binding site [nucleotide binding]; DNA binding site 691437005667 Predicted membrane protein [Function unknown]; Region: COG2323 691437005668 Spore germination protein; Region: Spore_permease; cl17796 691437005669 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 691437005670 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 691437005671 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 691437005672 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 691437005673 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437005674 dimer interface [polypeptide binding]; other site 691437005675 phosphorylation site [posttranslational modification] 691437005676 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437005677 ATP binding site [chemical binding]; other site 691437005678 Mg2+ binding site [ion binding]; other site 691437005679 G-X-G motif; other site 691437005680 tropinone reductase; Provisional; Region: PRK09242 691437005681 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437005682 NAD(P) binding site [chemical binding]; other site 691437005683 active site 691437005684 NETI protein; Region: NETI; pfam14044 691437005685 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 691437005686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437005687 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 691437005688 putative substrate translocation pore; other site 691437005689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437005690 HlyD family secretion protein; Region: HlyD_3; pfam13437 691437005691 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 691437005692 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 691437005693 MarR family; Region: MarR; pfam01047 691437005694 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 691437005695 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 691437005696 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 691437005697 enoyl-CoA hydratase; Provisional; Region: PRK07657 691437005698 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 691437005699 substrate binding site [chemical binding]; other site 691437005700 oxyanion hole (OAH) forming residues; other site 691437005701 trimer interface [polypeptide binding]; other site 691437005702 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 691437005703 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 691437005704 active site 691437005705 catalytic residues [active] 691437005706 metal binding site [ion binding]; metal-binding site 691437005707 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 691437005708 carboxyltransferase (CT) interaction site; other site 691437005709 biotinylation site [posttranslational modification]; other site 691437005710 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 691437005711 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 691437005712 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 691437005713 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 691437005714 AMP-binding domain protein; Validated; Region: PRK08315 691437005715 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 691437005716 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 691437005717 acyl-activating enzyme (AAE) consensus motif; other site 691437005718 putative AMP binding site [chemical binding]; other site 691437005719 putative active site [active] 691437005720 putative CoA binding site [chemical binding]; other site 691437005721 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 691437005722 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 691437005723 active site 691437005724 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 691437005725 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 691437005726 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 691437005727 Predicted acetyltransferase [General function prediction only]; Region: COG3393 691437005728 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 691437005729 threonine dehydratase; Provisional; Region: PRK08198 691437005730 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 691437005731 tetramer interface [polypeptide binding]; other site 691437005732 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437005733 catalytic residue [active] 691437005734 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 691437005735 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 691437005736 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 691437005737 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 691437005738 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 691437005739 putative active site [active] 691437005740 heme pocket [chemical binding]; other site 691437005741 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437005742 dimer interface [polypeptide binding]; other site 691437005743 phosphorylation site [posttranslational modification] 691437005744 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437005745 ATP binding site [chemical binding]; other site 691437005746 Mg2+ binding site [ion binding]; other site 691437005747 G-X-G motif; other site 691437005748 multidrug efflux protein; Reviewed; Region: PRK01766 691437005749 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 691437005750 cation binding site [ion binding]; other site 691437005751 Uncharacterized conserved protein [Function unknown]; Region: COG3342 691437005752 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 691437005753 Putative peptidoglycan binding domain; Region: PG_binding_2; pfam08823 691437005754 Predicted permeases [General function prediction only]; Region: RarD; COG2962 691437005755 EamA-like transporter family; Region: EamA; pfam00892 691437005756 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 691437005757 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 691437005758 oligomer interface [polypeptide binding]; other site 691437005759 metal binding site [ion binding]; metal-binding site 691437005760 metal binding site [ion binding]; metal-binding site 691437005761 putative Cl binding site [ion binding]; other site 691437005762 aspartate ring; other site 691437005763 basic sphincter; other site 691437005764 hydrophobic gate; other site 691437005765 periplasmic entrance; other site 691437005766 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 691437005767 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 691437005768 Methyltransferase domain; Region: Methyltransf_31; pfam13847 691437005769 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437005770 S-adenosylmethionine binding site [chemical binding]; other site 691437005771 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 691437005772 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 691437005773 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 691437005774 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 691437005775 YodL-like; Region: YodL; pfam14191 691437005776 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 691437005777 YozD-like protein; Region: YozD; pfam14162 691437005778 hypothetical protein; Provisional; Region: PRK13672 691437005779 biotin synthase; Validated; Region: PRK06256 691437005780 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 691437005781 FeS/SAM binding site; other site 691437005782 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 691437005783 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 691437005784 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 691437005785 Cl binding site [ion binding]; other site 691437005786 oligomer interface [polypeptide binding]; other site 691437005787 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 691437005788 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 691437005789 CoenzymeA binding site [chemical binding]; other site 691437005790 subunit interaction site [polypeptide binding]; other site 691437005791 PHB binding site; other site 691437005792 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 691437005793 active site 691437005794 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 691437005795 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 691437005796 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 691437005797 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 691437005798 catalytic residues [active] 691437005799 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 691437005800 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 691437005801 active site residue [active] 691437005802 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 691437005803 active site residue [active] 691437005804 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 691437005805 Protein of unknown function, DUF258; Region: DUF258; pfam03193 691437005806 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 691437005807 Dynamin family; Region: Dynamin_N; pfam00350 691437005808 G1 box; other site 691437005809 GTP/Mg2+ binding site [chemical binding]; other site 691437005810 G2 box; other site 691437005811 Switch I region; other site 691437005812 G3 box; other site 691437005813 Switch II region; other site 691437005814 G4 box; other site 691437005815 G5 box; other site 691437005816 Dynamin family; Region: Dynamin_N; pfam00350 691437005817 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 691437005818 G3 box; other site 691437005819 Switch II region; other site 691437005820 GTP/Mg2+ binding site [chemical binding]; other site 691437005821 G4 box; other site 691437005822 G5 box; other site 691437005823 Phospholipid methyltransferase; Region: PEMT; cl17370 691437005824 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 691437005825 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 691437005826 malonyl-CoA binding site [chemical binding]; other site 691437005827 dimer interface [polypeptide binding]; other site 691437005828 active site 691437005829 product binding site; other site 691437005830 Protein of unknown function (DUF1664); Region: DUF1664; pfam07889 691437005831 xanthine permease; Region: pbuX; TIGR03173 691437005832 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 691437005833 active site 691437005834 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 691437005835 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 691437005836 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 691437005837 D-pathway; other site 691437005838 Low-spin heme binding site [chemical binding]; other site 691437005839 Putative water exit pathway; other site 691437005840 Binuclear center (active site) [active] 691437005841 K-pathway; other site 691437005842 Putative proton exit pathway; other site 691437005843 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 691437005844 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 691437005845 active site 691437005846 Zn binding site [ion binding]; other site 691437005847 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 691437005848 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 691437005849 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 691437005850 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 691437005851 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437005852 S-adenosylmethionine binding site [chemical binding]; other site 691437005853 cell division protein GpsB; Provisional; Region: PRK14127 691437005854 DivIVA domain; Region: DivI1A_domain; TIGR03544 691437005855 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 691437005856 RNase_H superfamily; Region: RNase_H_2; pfam13482 691437005857 active site 691437005858 substrate binding site [chemical binding]; other site 691437005859 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 691437005860 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 691437005861 ATP binding site [chemical binding]; other site 691437005862 putative Mg++ binding site [ion binding]; other site 691437005863 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 691437005864 nucleotide binding region [chemical binding]; other site 691437005865 ATP-binding site [chemical binding]; other site 691437005866 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 691437005867 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 691437005868 Transcriptional regulator [Transcription]; Region: IclR; COG1414 691437005869 Bacterial transcriptional regulator; Region: IclR; pfam01614 691437005870 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 691437005871 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 691437005872 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 691437005873 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 691437005874 Malic enzyme, N-terminal domain; Region: malic; pfam00390 691437005875 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 691437005876 putative NAD(P) binding site [chemical binding]; other site 691437005877 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 691437005878 active site 691437005879 FAD binding domain; Region: FAD_binding_4; pfam01565 691437005880 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 691437005881 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 691437005882 Cysteine-rich domain; Region: CCG; pfam02754 691437005883 Cysteine-rich domain; Region: CCG; pfam02754 691437005884 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 691437005885 FAD binding domain; Region: FAD_binding_4; pfam01565 691437005886 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 691437005887 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 691437005888 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 691437005889 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 691437005890 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 691437005891 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 691437005892 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 691437005893 Walker A/P-loop; other site 691437005894 ATP binding site [chemical binding]; other site 691437005895 Q-loop/lid; other site 691437005896 ABC transporter signature motif; other site 691437005897 Walker B; other site 691437005898 D-loop; other site 691437005899 H-loop/switch region; other site 691437005900 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 691437005901 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 691437005902 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 691437005903 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 691437005904 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 691437005905 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 691437005906 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 691437005907 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 691437005908 dimer interface [polypeptide binding]; other site 691437005909 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437005910 catalytic residue [active] 691437005911 Histidine kinase N terminal; Region: HisK_N; pfam09385 691437005912 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 691437005913 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437005914 dimer interface [polypeptide binding]; other site 691437005915 phosphorylation site [posttranslational modification] 691437005916 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437005917 ATP binding site [chemical binding]; other site 691437005918 Mg2+ binding site [ion binding]; other site 691437005919 G-X-G motif; other site 691437005920 Domain of unknown function (DUF892); Region: DUF892; cl17410 691437005921 Coat F domain; Region: Coat_F; pfam07875 691437005922 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 691437005923 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 691437005924 active site 691437005925 catalytic triad [active] 691437005926 Uncharacterized conserved protein [Function unknown]; Region: COG1284 691437005927 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 691437005928 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 691437005929 small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861 691437005930 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 691437005931 Acyltransferase family; Region: Acyl_transf_3; pfam01757 691437005932 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 691437005933 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 691437005934 thiamine phosphate binding site [chemical binding]; other site 691437005935 active site 691437005936 pyrophosphate binding site [ion binding]; other site 691437005937 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 691437005938 dimer interface [polypeptide binding]; other site 691437005939 substrate binding site [chemical binding]; other site 691437005940 ATP binding site [chemical binding]; other site 691437005941 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 691437005942 substrate binding site [chemical binding]; other site 691437005943 multimerization interface [polypeptide binding]; other site 691437005944 ATP binding site [chemical binding]; other site 691437005945 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 691437005946 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 691437005947 Ligand binding site; other site 691437005948 Putative Catalytic site; other site 691437005949 DXD motif; other site 691437005950 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 691437005951 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 691437005952 active site 691437005953 substrate binding pocket [chemical binding]; other site 691437005954 homodimer interaction site [polypeptide binding]; other site 691437005955 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 691437005956 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 691437005957 Putative long-chain fatty acid CoA ligase; Region: LC_FACS_like; cd05935 691437005958 acyl-activating enzyme (AAE) consensus motif; other site 691437005959 putative AMP binding site [chemical binding]; other site 691437005960 putative active site [active] 691437005961 putative CoA binding site [chemical binding]; other site 691437005962 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 691437005963 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 691437005964 motif II; other site 691437005965 Excalibur calcium-binding domain; Region: Excalibur; cl05460 691437005966 Protein of unknown function (DUF523); Region: DUF523; pfam04463 691437005967 Uncharacterized conserved protein [Function unknown]; Region: COG3272 691437005968 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 691437005969 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 691437005970 putative active site [active] 691437005971 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 691437005972 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 691437005973 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 691437005974 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 691437005975 Transcriptional regulator [Transcription]; Region: IclR; COG1414 691437005976 Bacterial transcriptional regulator; Region: IclR; pfam01614 691437005977 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 691437005978 Coenzyme A binding pocket [chemical binding]; other site 691437005979 Uncharacterized conserved protein [Function unknown]; Region: COG0062 691437005980 putative carbohydrate kinase; Provisional; Region: PRK10565 691437005981 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 691437005982 putative substrate binding site [chemical binding]; other site 691437005983 putative ATP binding site [chemical binding]; other site 691437005984 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 691437005985 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 691437005986 Uncharacterized conserved protein [Function unknown]; Region: COG2135 691437005987 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 691437005988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437005989 active site 691437005990 phosphorylation site [posttranslational modification] 691437005991 intermolecular recognition site; other site 691437005992 dimerization interface [polypeptide binding]; other site 691437005993 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 691437005994 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 691437005995 metal binding site [ion binding]; metal-binding site 691437005996 active site 691437005997 I-site; other site 691437005998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437005999 Response regulator receiver domain; Region: Response_reg; pfam00072 691437006000 active site 691437006001 phosphorylation site [posttranslational modification] 691437006002 intermolecular recognition site; other site 691437006003 dimerization interface [polypeptide binding]; other site 691437006004 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 691437006005 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 691437006006 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 691437006007 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 691437006008 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 691437006009 active site 691437006010 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 691437006011 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 691437006012 acyl-activating enzyme (AAE) consensus motif; other site 691437006013 putative AMP binding site [chemical binding]; other site 691437006014 putative active site [active] 691437006015 putative CoA binding site [chemical binding]; other site 691437006016 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 691437006017 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 691437006018 DNA binding residues [nucleotide binding] 691437006019 putative dimer interface [polypeptide binding]; other site 691437006020 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 691437006021 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 691437006022 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 691437006023 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 691437006024 ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; Region: ABC_NatA_like; cd03267 691437006025 Walker A/P-loop; other site 691437006026 ATP binding site [chemical binding]; other site 691437006027 Q-loop/lid; other site 691437006028 ABC transporter signature motif; other site 691437006029 Walker B; other site 691437006030 D-loop; other site 691437006031 H-loop/switch region; other site 691437006032 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975 691437006033 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 691437006034 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 691437006035 Walker A/P-loop; other site 691437006036 ATP binding site [chemical binding]; other site 691437006037 Q-loop/lid; other site 691437006038 ABC transporter signature motif; other site 691437006039 Walker B; other site 691437006040 D-loop; other site 691437006041 H-loop/switch region; other site 691437006042 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 691437006043 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 691437006044 TM-ABC transporter signature motif; other site 691437006045 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 691437006046 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 691437006047 TM-ABC transporter signature motif; other site 691437006048 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 691437006049 Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360 691437006050 putative ligand binding site [chemical binding]; other site 691437006051 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 691437006052 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 691437006053 Cupin domain; Region: Cupin_2; pfam07883 691437006054 Cupin domain; Region: Cupin_2; pfam07883 691437006055 DinB superfamily; Region: DinB_2; pfam12867 691437006056 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 691437006057 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 691437006058 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 691437006059 active site 691437006060 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 691437006061 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 691437006062 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 691437006063 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 691437006064 acyl-activating enzyme (AAE) consensus motif; other site 691437006065 AMP binding site [chemical binding]; other site 691437006066 active site 691437006067 CoA binding site [chemical binding]; other site 691437006068 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 691437006069 dimerization interface [polypeptide binding]; other site 691437006070 Transcriptional regulator [Transcription]; Region: IclR; COG1414 691437006071 putative DNA binding site [nucleotide binding]; other site 691437006072 putative Zn2+ binding site [ion binding]; other site 691437006073 Bacterial transcriptional regulator; Region: IclR; pfam01614 691437006074 Transcriptional regulator [Transcription]; Region: IclR; COG1414 691437006075 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 691437006076 Bacterial transcriptional regulator; Region: IclR; pfam01614 691437006077 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 691437006078 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 691437006079 NAD(P) binding site [chemical binding]; other site 691437006080 catalytic residues [active] 691437006081 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 691437006082 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 691437006083 Walker A/P-loop; other site 691437006084 ATP binding site [chemical binding]; other site 691437006085 Q-loop/lid; other site 691437006086 ABC transporter signature motif; other site 691437006087 Walker B; other site 691437006088 D-loop; other site 691437006089 H-loop/switch region; other site 691437006090 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 691437006091 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 691437006092 Walker A/P-loop; other site 691437006093 ATP binding site [chemical binding]; other site 691437006094 Q-loop/lid; other site 691437006095 ABC transporter signature motif; other site 691437006096 Walker B; other site 691437006097 D-loop; other site 691437006098 H-loop/switch region; other site 691437006099 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 691437006100 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 691437006101 TM-ABC transporter signature motif; other site 691437006102 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 691437006103 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 691437006104 TM-ABC transporter signature motif; other site 691437006105 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 691437006106 Type I periplasmic binding proteins of active transport systems that are predicted to be involved in transport of aromatic compounds such as 2-nitrobenzoic acid and alkylbenzenes; Region: PBP1_aromatic_compounds_like; cd06332 691437006107 putative ligand binding site [chemical binding]; other site 691437006108 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 691437006109 active site 691437006110 metal binding site [ion binding]; metal-binding site 691437006111 4-oxalocrotonate tautomerase; Provisional; Region: PRK01964 691437006112 active site 1 [active] 691437006113 dimer interface [polypeptide binding]; other site 691437006114 hexamer interface [polypeptide binding]; other site 691437006115 active site 2 [active] 691437006116 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 691437006117 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 691437006118 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 691437006119 active site 691437006120 catalytic residues [active] 691437006121 metal binding site [ion binding]; metal-binding site 691437006122 DmpG-like communication domain; Region: DmpG_comm; pfam07836 691437006123 acetaldehyde dehydrogenase; Validated; Region: PRK08300 691437006124 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 691437006125 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 691437006126 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 691437006127 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 691437006128 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 691437006129 NAD binding site [chemical binding]; other site 691437006130 catalytic residues [active] 691437006131 Transcriptional regulator [Transcription]; Region: IclR; COG1414 691437006132 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 691437006133 putative DNA binding site [nucleotide binding]; other site 691437006134 putative Zn2+ binding site [ion binding]; other site 691437006135 Bacterial transcriptional regulator; Region: IclR; pfam01614 691437006136 Amidohydrolase; Region: Amidohydro_2; pfam04909 691437006137 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 691437006138 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 691437006139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437006140 putative substrate translocation pore; other site 691437006141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437006142 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 691437006143 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 691437006144 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 691437006145 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 691437006146 acyl-activating enzyme (AAE) consensus motif; other site 691437006147 putative AMP binding site [chemical binding]; other site 691437006148 putative active site [active] 691437006149 putative CoA binding site [chemical binding]; other site 691437006150 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 691437006151 Cupin domain; Region: Cupin_2; pfam07883 691437006152 Cupin domain; Region: Cupin_2; pfam07883 691437006153 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 691437006154 Transcriptional regulator [Transcription]; Region: IclR; COG1414 691437006155 Bacterial transcriptional regulator; Region: IclR; pfam01614 691437006156 putative acyltransferase; Provisional; Region: PRK05790 691437006157 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 691437006158 dimer interface [polypeptide binding]; other site 691437006159 active site 691437006160 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 691437006161 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 691437006162 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 691437006163 acyl-activating enzyme (AAE) consensus motif; other site 691437006164 acyl-activating enzyme (AAE) consensus motif; other site 691437006165 putative AMP binding site [chemical binding]; other site 691437006166 putative active site [active] 691437006167 putative CoA binding site [chemical binding]; other site 691437006168 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 691437006169 benzoate transport; Region: 2A0115; TIGR00895 691437006170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437006171 putative substrate translocation pore; other site 691437006172 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437006173 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 691437006174 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 691437006175 substrate binding site [chemical binding]; other site 691437006176 oxyanion hole (OAH) forming residues; other site 691437006177 trimer interface [polypeptide binding]; other site 691437006178 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 691437006179 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 691437006180 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 691437006181 GAF domain; Region: GAF; cl17456 691437006182 GAF domain; Region: GAF_2; pfam13185 691437006183 GAF domain; Region: GAF_2; pfam13185 691437006184 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 691437006185 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 691437006186 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 691437006187 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 691437006188 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 691437006189 acyl-activating enzyme (AAE) consensus motif; other site 691437006190 putative AMP binding site [chemical binding]; other site 691437006191 putative active site [active] 691437006192 putative CoA binding site [chemical binding]; other site 691437006193 FeoA domain; Region: FeoA; pfam04023 691437006194 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 691437006195 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 691437006196 G1 box; other site 691437006197 GTP/Mg2+ binding site [chemical binding]; other site 691437006198 Switch I region; other site 691437006199 G2 box; other site 691437006200 G3 box; other site 691437006201 Switch II region; other site 691437006202 G4 box; other site 691437006203 G5 box; other site 691437006204 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 691437006205 Nucleoside recognition; Region: Gate; pfam07670 691437006206 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 691437006207 Nucleoside recognition; Region: Gate; pfam07670 691437006208 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 691437006209 catalytic core [active] 691437006210 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700 691437006211 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 691437006212 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 691437006213 Coenzyme A binding pocket [chemical binding]; other site 691437006214 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 691437006215 PAS domain S-box; Region: sensory_box; TIGR00229 691437006216 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 691437006217 heme pocket [chemical binding]; other site 691437006218 putative active site [active] 691437006219 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 691437006220 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 691437006221 metal binding site [ion binding]; metal-binding site 691437006222 active site 691437006223 I-site; other site 691437006224 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 691437006225 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 691437006226 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 691437006227 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 691437006228 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 691437006229 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 691437006230 Walker A/P-loop; other site 691437006231 ATP binding site [chemical binding]; other site 691437006232 Q-loop/lid; other site 691437006233 ABC transporter signature motif; other site 691437006234 Walker B; other site 691437006235 D-loop; other site 691437006236 H-loop/switch region; other site 691437006237 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 691437006238 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 691437006239 ABC-ATPase subunit interface; other site 691437006240 dimer interface [polypeptide binding]; other site 691437006241 putative PBP binding regions; other site 691437006242 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 691437006243 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 691437006244 ABC-ATPase subunit interface; other site 691437006245 dimer interface [polypeptide binding]; other site 691437006246 putative PBP binding regions; other site 691437006247 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 691437006248 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 691437006249 siderophore binding site; other site 691437006250 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 691437006251 hypothetical protein; Provisional; Region: PRK07740 691437006252 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 691437006253 active site 691437006254 catalytic site [active] 691437006255 substrate binding site [chemical binding]; other site 691437006256 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 691437006257 metal binding triad; other site 691437006258 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 691437006259 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 691437006260 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 691437006261 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 691437006262 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 691437006263 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 691437006264 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 691437006265 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 691437006266 LysE type translocator; Region: LysE; cl00565 691437006267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437006268 Major Facilitator Superfamily; Region: MFS_1; pfam07690 691437006269 putative substrate translocation pore; other site 691437006270 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 691437006271 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 691437006272 alpha-mannosidase; Provisional; Region: PRK09819 691437006273 hypothetical protein; Provisional; Region: PRK02947 691437006274 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 691437006275 putative active site [active] 691437006276 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 691437006277 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 691437006278 Malic enzyme, N-terminal domain; Region: malic; pfam00390 691437006279 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 691437006280 putative NAD(P) binding site [chemical binding]; other site 691437006281 intracellular protease, PfpI family; Region: PfpI; TIGR01382 691437006282 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 691437006283 conserved cys residue [active] 691437006284 NAD-dependent deacetylase; Provisional; Region: PRK00481 691437006285 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 691437006286 NAD+ binding site [chemical binding]; other site 691437006287 substrate binding site [chemical binding]; other site 691437006288 Zn binding site [ion binding]; other site 691437006289 Phosphotransferase enzyme family; Region: APH; pfam01636 691437006290 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 691437006291 active site 691437006292 ATP binding site [chemical binding]; other site 691437006293 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 691437006294 substrate binding site [chemical binding]; other site 691437006295 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 691437006296 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 691437006297 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 691437006298 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 691437006299 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 691437006300 active site 691437006301 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 691437006302 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 691437006303 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 691437006304 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 691437006305 active site 691437006306 dimer interface [polypeptide binding]; other site 691437006307 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 691437006308 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 691437006309 active site 691437006310 FMN binding site [chemical binding]; other site 691437006311 substrate binding site [chemical binding]; other site 691437006312 3Fe-4S cluster binding site [ion binding]; other site 691437006313 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 691437006314 domain interface; other site 691437006315 Transcriptional regulator [Transcription]; Region: LysR; COG0583 691437006316 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 691437006317 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 691437006318 putative dimerization interface [polypeptide binding]; other site 691437006319 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 691437006320 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 691437006321 putative NADP binding site [chemical binding]; other site 691437006322 putative dimer interface [polypeptide binding]; other site 691437006323 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 691437006324 putative active site [active] 691437006325 aminotransferase; Validated; Region: PRK07678 691437006326 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 691437006327 inhibitor-cofactor binding pocket; inhibition site 691437006328 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437006329 catalytic residue [active] 691437006330 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 691437006331 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 691437006332 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 691437006333 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 691437006334 DNA methylase; Region: N6_N4_Mtase; pfam01555 691437006335 DNA methylase; Region: N6_N4_Mtase; cl17433 691437006336 AAA domain; Region: AAA_11; pfam13086 691437006337 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 691437006338 ATP binding site [chemical binding]; other site 691437006339 putative Mg++ binding site [ion binding]; other site 691437006340 AAA domain; Region: AAA_12; pfam13087 691437006341 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 691437006342 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 691437006343 putative ligand binding residues [chemical binding]; other site 691437006344 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 691437006345 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 691437006346 Walker A/P-loop; other site 691437006347 ATP binding site [chemical binding]; other site 691437006348 Q-loop/lid; other site 691437006349 ABC transporter signature motif; other site 691437006350 Walker B; other site 691437006351 D-loop; other site 691437006352 H-loop/switch region; other site 691437006353 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 691437006354 ABC-ATPase subunit interface; other site 691437006355 dimer interface [polypeptide binding]; other site 691437006356 putative PBP binding regions; other site 691437006357 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 691437006358 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 691437006359 ABC-ATPase subunit interface; other site 691437006360 dimer interface [polypeptide binding]; other site 691437006361 putative PBP binding regions; other site 691437006362 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 691437006363 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 691437006364 NAD(P) binding site [chemical binding]; other site 691437006365 catalytic residues [active] 691437006366 sulfite reductase subunit beta; Provisional; Region: PRK13504 691437006367 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 691437006368 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 691437006369 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 691437006370 Flavodoxin; Region: Flavodoxin_1; pfam00258 691437006371 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 691437006372 FAD binding pocket [chemical binding]; other site 691437006373 FAD binding motif [chemical binding]; other site 691437006374 catalytic residues [active] 691437006375 NAD binding pocket [chemical binding]; other site 691437006376 phosphate binding motif [ion binding]; other site 691437006377 beta-alpha-beta structure motif; other site 691437006378 Transcriptional regulator [Transcription]; Region: LysR; COG0583 691437006379 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 691437006380 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 691437006381 putative dimerization interface [polypeptide binding]; other site 691437006382 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 691437006383 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 691437006384 dimerization interface [polypeptide binding]; other site 691437006385 putative DNA binding site [nucleotide binding]; other site 691437006386 putative Zn2+ binding site [ion binding]; other site 691437006387 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 691437006388 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 691437006389 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 691437006390 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 691437006391 hydroxyglutarate oxidase; Provisional; Region: PRK11728 691437006392 hypothetical protein; Provisional; Region: PRK03057 691437006393 UPF0302 domain; Region: UPF0302; pfam08864 691437006394 A short protein domain of unknown function; Region: IDEAL; smart00914 691437006395 malate:quinone oxidoreductase; Validated; Region: PRK05257 691437006396 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 691437006397 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 691437006398 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 691437006399 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 691437006400 Uncharacterized conserved protein [Function unknown]; Region: COG4127 691437006401 EVE domain; Region: EVE; cl00728 691437006402 Restriction endonuclease; Region: Mrr_cat; pfam04471 691437006403 Restriction endonuclease [Defense mechanisms]; Region: COG3587 691437006404 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 691437006405 ATP binding site [chemical binding]; other site 691437006406 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 691437006407 DNA methylase; Region: N6_N4_Mtase; cl17433 691437006408 DNA methylase; Region: N6_N4_Mtase; pfam01555 691437006409 DNA methylase; Region: N6_N4_Mtase; cl17433 691437006410 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 691437006411 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 691437006412 non-specific DNA binding site [nucleotide binding]; other site 691437006413 salt bridge; other site 691437006414 sequence-specific DNA binding site [nucleotide binding]; other site 691437006415 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 691437006416 Protein of unknown function (DUF524); Region: DUF524; pfam04411 691437006417 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 691437006418 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 691437006419 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 691437006420 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 691437006421 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 691437006422 putative active site [active] 691437006423 metal binding site [ion binding]; metal-binding site 691437006424 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 691437006425 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 691437006426 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 691437006427 non-specific DNA binding site [nucleotide binding]; other site 691437006428 salt bridge; other site 691437006429 sequence-specific DNA binding site [nucleotide binding]; other site 691437006430 Domain of unknown function (DUF955); Region: DUF955; cl01076 691437006431 HEAT repeats; Region: HEAT_2; pfam13646 691437006432 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 691437006433 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 691437006434 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 691437006435 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 691437006436 Probable transposase; Region: OrfB_IS605; pfam01385 691437006437 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 691437006438 Predicted transporter component [General function prediction only]; Region: COG2391 691437006439 Sulphur transport; Region: Sulf_transp; pfam04143 691437006440 Sulphur transport; Region: Sulf_transp; pfam04143 691437006441 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13953 691437006442 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 691437006443 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 691437006444 Nucleoside recognition; Region: Gate; pfam07670 691437006445 imidazolonepropionase; Validated; Region: PRK09356 691437006446 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 691437006447 active site 691437006448 urocanate hydratase; Provisional; Region: PRK05414 691437006449 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 691437006450 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 691437006451 formimidoylglutamase; Provisional; Region: PRK13775 691437006452 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 691437006453 putative active site [active] 691437006454 putative metal binding site [ion binding]; other site 691437006455 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 691437006456 CoenzymeA binding site [chemical binding]; other site 691437006457 subunit interaction site [polypeptide binding]; other site 691437006458 PHB binding site; other site 691437006459 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 691437006460 CoenzymeA binding site [chemical binding]; other site 691437006461 subunit interaction site [polypeptide binding]; other site 691437006462 PHB binding site; other site 691437006463 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 691437006464 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 691437006465 active site 691437006466 metal binding site [ion binding]; metal-binding site 691437006467 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 691437006468 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 691437006469 peptide binding site [polypeptide binding]; other site 691437006470 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 691437006471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437006472 dimer interface [polypeptide binding]; other site 691437006473 conserved gate region; other site 691437006474 putative PBP binding loops; other site 691437006475 ABC-ATPase subunit interface; other site 691437006476 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 691437006477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437006478 dimer interface [polypeptide binding]; other site 691437006479 conserved gate region; other site 691437006480 putative PBP binding loops; other site 691437006481 ABC-ATPase subunit interface; other site 691437006482 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 691437006483 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 691437006484 Walker A/P-loop; other site 691437006485 ATP binding site [chemical binding]; other site 691437006486 Q-loop/lid; other site 691437006487 ABC transporter signature motif; other site 691437006488 Walker B; other site 691437006489 D-loop; other site 691437006490 H-loop/switch region; other site 691437006491 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 691437006492 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 691437006493 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 691437006494 Walker A/P-loop; other site 691437006495 ATP binding site [chemical binding]; other site 691437006496 Q-loop/lid; other site 691437006497 ABC transporter signature motif; other site 691437006498 Walker B; other site 691437006499 D-loop; other site 691437006500 H-loop/switch region; other site 691437006501 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 691437006502 glycerol kinase; Provisional; Region: glpK; PRK00047 691437006503 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 691437006504 N- and C-terminal domain interface [polypeptide binding]; other site 691437006505 active site 691437006506 MgATP binding site [chemical binding]; other site 691437006507 catalytic site [active] 691437006508 metal binding site [ion binding]; metal-binding site 691437006509 glycerol binding site [chemical binding]; other site 691437006510 homotetramer interface [polypeptide binding]; other site 691437006511 homodimer interface [polypeptide binding]; other site 691437006512 FBP binding site [chemical binding]; other site 691437006513 protein IIAGlc interface [polypeptide binding]; other site 691437006514 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 691437006515 amphipathic channel; other site 691437006516 Asn-Pro-Ala signature motifs; other site 691437006517 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 691437006518 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 691437006519 DNA-binding site [nucleotide binding]; DNA binding site 691437006520 RNA-binding motif; other site 691437006521 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 691437006522 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 691437006523 hypothetical protein; Validated; Region: PRK07708 691437006524 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 691437006525 RNA/DNA hybrid binding site [nucleotide binding]; other site 691437006526 active site 691437006527 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 691437006528 EamA-like transporter family; Region: EamA; pfam00892 691437006529 EamA-like transporter family; Region: EamA; pfam00892 691437006530 Divergent PAP2 family; Region: DUF212; pfam02681 691437006531 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 691437006532 aconitate hydratase; Validated; Region: PRK09277 691437006533 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 691437006534 substrate binding site [chemical binding]; other site 691437006535 ligand binding site [chemical binding]; other site 691437006536 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 691437006537 substrate binding site [chemical binding]; other site 691437006538 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 691437006539 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 691437006540 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 691437006541 methionine cluster; other site 691437006542 active site 691437006543 phosphorylation site [posttranslational modification] 691437006544 metal binding site [ion binding]; metal-binding site 691437006545 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 691437006546 putative active site [active] 691437006547 YdjC motif; other site 691437006548 Mg binding site [ion binding]; other site 691437006549 putative homodimer interface [polypeptide binding]; other site 691437006550 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 691437006551 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 691437006552 active site 691437006553 P-loop; other site 691437006554 phosphorylation site [posttranslational modification] 691437006555 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 691437006556 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 691437006557 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437006558 Walker A motif; other site 691437006559 ATP binding site [chemical binding]; other site 691437006560 Walker B motif; other site 691437006561 arginine finger; other site 691437006562 Transcriptional antiterminator [Transcription]; Region: COG3933 691437006563 PRD domain; Region: PRD; pfam00874 691437006564 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 691437006565 active pocket/dimerization site; other site 691437006566 active site 691437006567 phosphorylation site [posttranslational modification] 691437006568 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 691437006569 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 691437006570 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 691437006571 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 691437006572 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 691437006573 Response regulator receiver domain; Region: Response_reg; pfam00072 691437006574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437006575 active site 691437006576 phosphorylation site [posttranslational modification] 691437006577 intermolecular recognition site; other site 691437006578 dimerization interface [polypeptide binding]; other site 691437006579 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 691437006580 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 691437006581 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 691437006582 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 691437006583 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 691437006584 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 691437006585 Walker A/P-loop; other site 691437006586 ATP binding site [chemical binding]; other site 691437006587 Q-loop/lid; other site 691437006588 ABC transporter signature motif; other site 691437006589 Walker B; other site 691437006590 D-loop; other site 691437006591 H-loop/switch region; other site 691437006592 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 691437006593 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 691437006594 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 691437006595 Walker A/P-loop; other site 691437006596 ATP binding site [chemical binding]; other site 691437006597 Q-loop/lid; other site 691437006598 ABC transporter signature motif; other site 691437006599 Walker B; other site 691437006600 D-loop; other site 691437006601 H-loop/switch region; other site 691437006602 hypothetical protein; Provisional; Region: PRK01844 691437006603 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 691437006604 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 691437006605 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 691437006606 TPP-binding site [chemical binding]; other site 691437006607 dimer interface [polypeptide binding]; other site 691437006608 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 691437006609 PYR/PP interface [polypeptide binding]; other site 691437006610 dimer interface [polypeptide binding]; other site 691437006611 TPP binding site [chemical binding]; other site 691437006612 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 691437006613 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 691437006614 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 691437006615 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 691437006616 catalytic residues [active] 691437006617 catalytic nucleophile [active] 691437006618 cell division suppressor protein YneA; Provisional; Region: PRK14125 691437006619 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 691437006620 LexA repressor; Validated; Region: PRK00215 691437006621 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 691437006622 putative DNA binding site [nucleotide binding]; other site 691437006623 putative Zn2+ binding site [ion binding]; other site 691437006624 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 691437006625 Catalytic site [active] 691437006626 glutamine synthetase, type I; Region: GlnA; TIGR00653 691437006627 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 691437006628 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 691437006629 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 691437006630 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 691437006631 DNA binding residues [nucleotide binding] 691437006632 putative dimer interface [polypeptide binding]; other site 691437006633 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 691437006634 Aluminium resistance protein; Region: Alum_res; pfam06838 691437006635 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 691437006636 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 691437006637 HflX GTPase family; Region: HflX; cd01878 691437006638 G1 box; other site 691437006639 GTP/Mg2+ binding site [chemical binding]; other site 691437006640 Switch I region; other site 691437006641 G2 box; other site 691437006642 G3 box; other site 691437006643 Switch II region; other site 691437006644 G4 box; other site 691437006645 G5 box; other site 691437006646 Predicted membrane protein [Function unknown]; Region: COG2860 691437006647 UPF0126 domain; Region: UPF0126; pfam03458 691437006648 UPF0126 domain; Region: UPF0126; pfam03458 691437006649 EamA-like transporter family; Region: EamA; pfam00892 691437006650 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 691437006651 EamA-like transporter family; Region: EamA; pfam00892 691437006652 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 691437006653 putative active site [active] 691437006654 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 691437006655 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 691437006656 dimer interface [polypeptide binding]; other site 691437006657 active site 691437006658 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 691437006659 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 691437006660 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 691437006661 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 691437006662 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 691437006663 dimer interface [polypeptide binding]; other site 691437006664 acyl-activating enzyme (AAE) consensus motif; other site 691437006665 putative active site [active] 691437006666 AMP binding site [chemical binding]; other site 691437006667 putative CoA binding site [chemical binding]; other site 691437006668 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 691437006669 CoA-transferase family III; Region: CoA_transf_3; pfam02515 691437006670 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 691437006671 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 691437006672 active site 691437006673 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 691437006674 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 691437006675 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 691437006676 acyl-activating enzyme (AAE) consensus motif; other site 691437006677 acyl-activating enzyme (AAE) consensus motif; other site 691437006678 putative active site [active] 691437006679 putative AMP binding site [chemical binding]; other site 691437006680 putative CoA binding site [chemical binding]; other site 691437006681 stage V sporulation protein K; Region: spore_V_K; TIGR02881 691437006682 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437006683 Walker A motif; other site 691437006684 ATP binding site [chemical binding]; other site 691437006685 Walker B motif; other site 691437006686 arginine finger; other site 691437006687 bacterial Hfq-like; Region: Hfq; cd01716 691437006688 hexamer interface [polypeptide binding]; other site 691437006689 Sm1 motif; other site 691437006690 RNA binding site [nucleotide binding]; other site 691437006691 Sm2 motif; other site 691437006692 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 691437006693 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 691437006694 CHASE3 domain; Region: CHASE3; cl05000 691437006695 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 691437006696 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 691437006697 dimerization interface [polypeptide binding]; other site 691437006698 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 691437006699 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 691437006700 dimer interface [polypeptide binding]; other site 691437006701 putative CheW interface [polypeptide binding]; other site 691437006702 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 691437006703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437006704 putative substrate translocation pore; other site 691437006705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437006706 BCCT family transporter; Region: BCCT; pfam02028 691437006707 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 691437006708 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 691437006709 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 691437006710 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 691437006711 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 691437006712 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 691437006713 NlpC/P60 family; Region: NLPC_P60; pfam00877 691437006714 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 691437006715 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437006716 ATP binding site [chemical binding]; other site 691437006717 Mg2+ binding site [ion binding]; other site 691437006718 G-X-G motif; other site 691437006719 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 691437006720 ATP binding site [chemical binding]; other site 691437006721 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 691437006722 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 691437006723 MutS domain I; Region: MutS_I; pfam01624 691437006724 MutS domain II; Region: MutS_II; pfam05188 691437006725 MutS domain III; Region: MutS_III; pfam05192 691437006726 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 691437006727 Walker A/P-loop; other site 691437006728 ATP binding site [chemical binding]; other site 691437006729 Q-loop/lid; other site 691437006730 ABC transporter signature motif; other site 691437006731 Walker B; other site 691437006732 D-loop; other site 691437006733 H-loop/switch region; other site 691437006734 Outer spore coat protein E (CotE); Region: CotE; pfam10628 691437006735 Predicted membrane protein [Function unknown]; Region: COG4550 691437006736 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 691437006737 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 691437006738 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 691437006739 FeS/SAM binding site; other site 691437006740 TRAM domain; Region: TRAM; cl01282 691437006741 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 691437006742 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 691437006743 TPP-binding site [chemical binding]; other site 691437006744 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 691437006745 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 691437006746 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 691437006747 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 691437006748 dimer interface [polypeptide binding]; other site 691437006749 PYR/PP interface [polypeptide binding]; other site 691437006750 TPP binding site [chemical binding]; other site 691437006751 substrate binding site [chemical binding]; other site 691437006752 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 691437006753 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 691437006754 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 691437006755 active site 691437006756 dimer interface [polypeptide binding]; other site 691437006757 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 691437006758 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 691437006759 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 691437006760 putative active site [active] 691437006761 metal binding site [ion binding]; metal-binding site 691437006762 homodimer binding site [polypeptide binding]; other site 691437006763 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 691437006764 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 691437006765 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 691437006766 Zn2+ binding site [ion binding]; other site 691437006767 Mg2+ binding site [ion binding]; other site 691437006768 Cation efflux family; Region: Cation_efflux; cl00316 691437006769 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 691437006770 recombinase A; Provisional; Region: recA; PRK09354 691437006771 recA bacterial DNA recombination protein; Region: RecA; cl17211 691437006772 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 691437006773 Walker A motif; other site 691437006774 ATP binding site [chemical binding]; other site 691437006775 competence damage-inducible protein A; Provisional; Region: PRK00549 691437006776 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 691437006777 putative MPT binding site; other site 691437006778 Competence-damaged protein; Region: CinA; pfam02464 691437006779 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 691437006780 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 691437006781 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 691437006782 non-specific DNA binding site [nucleotide binding]; other site 691437006783 salt bridge; other site 691437006784 sequence-specific DNA binding site [nucleotide binding]; other site 691437006785 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 691437006786 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 691437006787 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 691437006788 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 691437006789 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 691437006790 classical (c) SDRs; Region: SDR_c; cd05233 691437006791 NAD(P) binding site [chemical binding]; other site 691437006792 active site 691437006793 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 691437006794 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 691437006795 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 691437006796 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 691437006797 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 691437006798 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 691437006799 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 691437006800 TM-ABC transporter signature motif; other site 691437006801 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 691437006802 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 691437006803 TM-ABC transporter signature motif; other site 691437006804 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 691437006805 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 691437006806 Walker A/P-loop; other site 691437006807 ATP binding site [chemical binding]; other site 691437006808 Q-loop/lid; other site 691437006809 ABC transporter signature motif; other site 691437006810 Walker B; other site 691437006811 D-loop; other site 691437006812 H-loop/switch region; other site 691437006813 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 691437006814 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 691437006815 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 691437006816 ligand binding site [chemical binding]; other site 691437006817 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 691437006818 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 691437006819 DNA-binding site [nucleotide binding]; DNA binding site 691437006820 UTRA domain; Region: UTRA; pfam07702 691437006821 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 691437006822 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 691437006823 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 691437006824 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 691437006825 YlzJ-like protein; Region: YlzJ; pfam14035 691437006826 Clp protease; Region: CLP_protease; pfam00574 691437006827 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 691437006828 active site 691437006829 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 691437006830 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 691437006831 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 691437006832 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 691437006833 dihydrodipicolinate synthase; Region: dapA; TIGR00674 691437006834 dimer interface [polypeptide binding]; other site 691437006835 active site 691437006836 catalytic residue [active] 691437006837 aspartate kinase I; Reviewed; Region: PRK08210 691437006838 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 691437006839 nucleotide binding site [chemical binding]; other site 691437006840 substrate binding site [chemical binding]; other site 691437006841 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 691437006842 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 691437006843 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 691437006844 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 691437006845 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 691437006846 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 691437006847 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 691437006848 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 691437006849 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 691437006850 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 691437006851 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 691437006852 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 691437006853 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 691437006854 NodB motif; other site 691437006855 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 691437006856 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 691437006857 RNase E interface [polypeptide binding]; other site 691437006858 trimer interface [polypeptide binding]; other site 691437006859 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 691437006860 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 691437006861 RNase E interface [polypeptide binding]; other site 691437006862 trimer interface [polypeptide binding]; other site 691437006863 active site 691437006864 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 691437006865 putative nucleic acid binding region [nucleotide binding]; other site 691437006866 G-X-X-G motif; other site 691437006867 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 691437006868 RNA binding site [nucleotide binding]; other site 691437006869 domain interface; other site 691437006870 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 691437006871 16S/18S rRNA binding site [nucleotide binding]; other site 691437006872 S13e-L30e interaction site [polypeptide binding]; other site 691437006873 25S rRNA binding site [nucleotide binding]; other site 691437006874 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 691437006875 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 691437006876 active site 691437006877 Riboflavin kinase; Region: Flavokinase; smart00904 691437006878 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 691437006879 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 691437006880 RNA binding site [nucleotide binding]; other site 691437006881 active site 691437006882 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 691437006883 Protein of unknown function (DUF503); Region: DUF503; pfam04456 691437006884 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 691437006885 translation initiation factor IF-2; Region: IF-2; TIGR00487 691437006886 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 691437006887 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 691437006888 G1 box; other site 691437006889 putative GEF interaction site [polypeptide binding]; other site 691437006890 GTP/Mg2+ binding site [chemical binding]; other site 691437006891 Switch I region; other site 691437006892 G2 box; other site 691437006893 G3 box; other site 691437006894 Switch II region; other site 691437006895 G4 box; other site 691437006896 G5 box; other site 691437006897 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 691437006898 Translation-initiation factor 2; Region: IF-2; pfam11987 691437006899 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 691437006900 hypothetical protein; Provisional; Region: PRK07714 691437006901 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 691437006902 putative RNA binding cleft [nucleotide binding]; other site 691437006903 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 691437006904 NusA N-terminal domain; Region: NusA_N; pfam08529 691437006905 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 691437006906 RNA binding site [nucleotide binding]; other site 691437006907 homodimer interface [polypeptide binding]; other site 691437006908 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 691437006909 G-X-X-G motif; other site 691437006910 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 691437006911 G-X-X-G motif; other site 691437006912 ribosome maturation protein RimP; Reviewed; Region: PRK00092 691437006913 Sm and related proteins; Region: Sm_like; cl00259 691437006914 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 691437006915 putative oligomer interface [polypeptide binding]; other site 691437006916 putative RNA binding site [nucleotide binding]; other site 691437006917 DNA polymerase III PolC; Validated; Region: polC; PRK00448 691437006918 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 691437006919 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 691437006920 generic binding surface I; other site 691437006921 generic binding surface II; other site 691437006922 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 691437006923 active site 691437006924 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 691437006925 active site 691437006926 catalytic site [active] 691437006927 substrate binding site [chemical binding]; other site 691437006928 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 691437006929 prolyl-tRNA synthetase; Provisional; Region: PRK09194 691437006930 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 691437006931 dimer interface [polypeptide binding]; other site 691437006932 motif 1; other site 691437006933 active site 691437006934 motif 2; other site 691437006935 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 691437006936 putative deacylase active site [active] 691437006937 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 691437006938 active site 691437006939 motif 3; other site 691437006940 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 691437006941 anticodon binding site; other site 691437006942 RIP metalloprotease RseP; Region: TIGR00054 691437006943 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 691437006944 active site 691437006945 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 691437006946 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 691437006947 protein binding site [polypeptide binding]; other site 691437006948 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 691437006949 putative substrate binding region [chemical binding]; other site 691437006950 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 691437006951 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 691437006952 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 691437006953 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 691437006954 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 691437006955 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 691437006956 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 691437006957 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 691437006958 catalytic residue [active] 691437006959 putative FPP diphosphate binding site; other site 691437006960 putative FPP binding hydrophobic cleft; other site 691437006961 dimer interface [polypeptide binding]; other site 691437006962 putative IPP diphosphate binding site; other site 691437006963 ribosome recycling factor; Reviewed; Region: frr; PRK00083 691437006964 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 691437006965 hinge region; other site 691437006966 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 691437006967 putative nucleotide binding site [chemical binding]; other site 691437006968 uridine monophosphate binding site [chemical binding]; other site 691437006969 homohexameric interface [polypeptide binding]; other site 691437006970 elongation factor Ts; Provisional; Region: tsf; PRK09377 691437006971 UBA/TS-N domain; Region: UBA; pfam00627 691437006972 Elongation factor TS; Region: EF_TS; pfam00889 691437006973 Elongation factor TS; Region: EF_TS; pfam00889 691437006974 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 691437006975 rRNA interaction site [nucleotide binding]; other site 691437006976 S8 interaction site; other site 691437006977 putative laminin-1 binding site; other site 691437006978 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 691437006979 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 691437006980 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 691437006981 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 691437006982 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 691437006983 DNA binding residues [nucleotide binding] 691437006984 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 691437006985 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 691437006986 Chemotaxis phosphatase CheX; Region: CheX; cl15816 691437006987 CheC-like family; Region: CheC; pfam04509 691437006988 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 691437006989 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 691437006990 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 691437006991 putative binding surface; other site 691437006992 active site 691437006993 P2 response regulator binding domain; Region: P2; pfam07194 691437006994 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 691437006995 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437006996 ATP binding site [chemical binding]; other site 691437006997 Mg2+ binding site [ion binding]; other site 691437006998 G-X-G motif; other site 691437006999 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 691437007000 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 691437007001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437007002 active site 691437007003 phosphorylation site [posttranslational modification] 691437007004 intermolecular recognition site; other site 691437007005 dimerization interface [polypeptide binding]; other site 691437007006 CheB methylesterase; Region: CheB_methylest; pfam01339 691437007007 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 691437007008 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 691437007009 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 691437007010 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 691437007011 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 691437007012 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 691437007013 FHIPEP family; Region: FHIPEP; pfam00771 691437007014 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 691437007015 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 691437007016 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 691437007017 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 691437007018 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 691437007019 flagella biosynthesis protein FliZ; Provisional; Region: PRK13415 691437007020 Response regulator receiver domain; Region: Response_reg; pfam00072 691437007021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437007022 active site 691437007023 phosphorylation site [posttranslational modification] 691437007024 intermolecular recognition site; other site 691437007025 dimerization interface [polypeptide binding]; other site 691437007026 flagellar motor switch protein; Validated; Region: PRK08119 691437007027 CheC-like family; Region: CheC; pfam04509 691437007028 CheC-like family; Region: CheC; pfam04509 691437007029 flagellar motor switch protein FliN; Region: fliN; TIGR02480 691437007030 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 691437007031 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 691437007032 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 691437007033 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 691437007034 Flagellar protein (FlbD); Region: FlbD; pfam06289 691437007035 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 691437007036 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 691437007037 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 691437007038 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 691437007039 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 691437007040 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 691437007041 MgtE intracellular N domain; Region: MgtE_N; cl15244 691437007042 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 691437007043 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 691437007044 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 691437007045 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 691437007046 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 691437007047 Walker A motif/ATP binding site; other site 691437007048 Walker B motif; other site 691437007049 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 691437007050 Flagellar assembly protein FliH; Region: FliH; pfam02108 691437007051 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 691437007052 MgtE intracellular N domain; Region: MgtE_N; cl15244 691437007053 FliG C-terminal domain; Region: FliG_C; pfam01706 691437007054 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 691437007055 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 691437007056 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 691437007057 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 691437007058 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 691437007059 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 691437007060 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 691437007061 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 691437007062 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 691437007063 transcriptional repressor CodY; Validated; Region: PRK04158 691437007064 CodY GAF-like domain; Region: CodY; pfam06018 691437007065 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 691437007066 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 691437007067 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437007068 Walker A motif; other site 691437007069 ATP binding site [chemical binding]; other site 691437007070 Walker B motif; other site 691437007071 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 691437007072 Walker B motif; other site 691437007073 arginine finger; other site 691437007074 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 691437007075 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 691437007076 active site 691437007077 HslU subunit interaction site [polypeptide binding]; other site 691437007078 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 691437007079 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 691437007080 active site 691437007081 Int/Topo IB signature motif; other site 691437007082 DNA topoisomerase I; Validated; Region: PRK05582 691437007083 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 691437007084 active site 691437007085 interdomain interaction site; other site 691437007086 putative metal-binding site [ion binding]; other site 691437007087 nucleotide binding site [chemical binding]; other site 691437007088 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 691437007089 domain I; other site 691437007090 DNA binding groove [nucleotide binding] 691437007091 phosphate binding site [ion binding]; other site 691437007092 domain II; other site 691437007093 domain III; other site 691437007094 nucleotide binding site [chemical binding]; other site 691437007095 catalytic site [active] 691437007096 domain IV; other site 691437007097 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 691437007098 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 691437007099 DNA protecting protein DprA; Region: dprA; TIGR00732 691437007100 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 691437007101 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 691437007102 CoA binding domain; Region: CoA_binding; pfam02629 691437007103 CoA-ligase; Region: Ligase_CoA; pfam00549 691437007104 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 691437007105 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 691437007106 CoA-ligase; Region: Ligase_CoA; pfam00549 691437007107 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 691437007108 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 691437007109 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 691437007110 RNA/DNA hybrid binding site [nucleotide binding]; other site 691437007111 active site 691437007112 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 691437007113 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 691437007114 GTP/Mg2+ binding site [chemical binding]; other site 691437007115 G4 box; other site 691437007116 G5 box; other site 691437007117 G1 box; other site 691437007118 Switch I region; other site 691437007119 G2 box; other site 691437007120 G3 box; other site 691437007121 Switch II region; other site 691437007122 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 691437007123 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 691437007124 Catalytic site [active] 691437007125 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 691437007126 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 691437007127 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 691437007128 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 691437007129 RimM N-terminal domain; Region: RimM; pfam01782 691437007130 PRC-barrel domain; Region: PRC; pfam05239 691437007131 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 691437007132 KH domain; Region: KH_4; pfam13083 691437007133 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 691437007134 signal recognition particle protein; Provisional; Region: PRK10867 691437007135 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 691437007136 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 691437007137 P loop; other site 691437007138 GTP binding site [chemical binding]; other site 691437007139 Signal peptide binding domain; Region: SRP_SPB; pfam02978 691437007140 putative DNA-binding protein; Validated; Region: PRK00118 691437007141 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 691437007142 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 691437007143 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 691437007144 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 691437007145 P loop; other site 691437007146 GTP binding site [chemical binding]; other site 691437007147 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 691437007148 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 691437007149 Walker A/P-loop; other site 691437007150 ATP binding site [chemical binding]; other site 691437007151 Q-loop/lid; other site 691437007152 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 691437007153 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 691437007154 ABC transporter signature motif; other site 691437007155 Walker B; other site 691437007156 D-loop; other site 691437007157 H-loop/switch region; other site 691437007158 ribonuclease III; Reviewed; Region: rnc; PRK00102 691437007159 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 691437007160 dimerization interface [polypeptide binding]; other site 691437007161 active site 691437007162 metal binding site [ion binding]; metal-binding site 691437007163 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 691437007164 dsRNA binding site [nucleotide binding]; other site 691437007165 acyl carrier protein; Provisional; Region: acpP; PRK00982 691437007166 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 691437007167 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 691437007168 NAD(P) binding site [chemical binding]; other site 691437007169 homotetramer interface [polypeptide binding]; other site 691437007170 homodimer interface [polypeptide binding]; other site 691437007171 active site 691437007172 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 691437007173 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 691437007174 putative phosphate acyltransferase; Provisional; Region: PRK05331 691437007175 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 691437007176 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 691437007177 active site 2 [active] 691437007178 active site 1 [active] 691437007179 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 691437007180 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 691437007181 generic binding surface II; other site 691437007182 ssDNA binding site; other site 691437007183 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 691437007184 ATP binding site [chemical binding]; other site 691437007185 putative Mg++ binding site [ion binding]; other site 691437007186 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 691437007187 nucleotide binding region [chemical binding]; other site 691437007188 ATP-binding site [chemical binding]; other site 691437007189 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 691437007190 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 691437007191 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 691437007192 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 691437007193 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 691437007194 putative L-serine binding site [chemical binding]; other site 691437007195 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 691437007196 DAK2 domain; Region: Dak2; pfam02734 691437007197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 691437007198 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 691437007199 stage V sporulation protein M; Provisional; Region: spoVM; PRK14741 691437007200 Thiamine pyrophosphokinase; Region: TPK; cd07995 691437007201 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 691437007202 active site 691437007203 dimerization interface [polypeptide binding]; other site 691437007204 thiamine binding site [chemical binding]; other site 691437007205 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 691437007206 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 691437007207 substrate binding site [chemical binding]; other site 691437007208 hexamer interface [polypeptide binding]; other site 691437007209 metal binding site [ion binding]; metal-binding site 691437007210 GTPase RsgA; Reviewed; Region: PRK00098 691437007211 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 691437007212 RNA binding site [nucleotide binding]; other site 691437007213 homodimer interface [polypeptide binding]; other site 691437007214 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 691437007215 GTPase/Zn-binding domain interface [polypeptide binding]; other site 691437007216 GTP/Mg2+ binding site [chemical binding]; other site 691437007217 G4 box; other site 691437007218 G5 box; other site 691437007219 G1 box; other site 691437007220 Switch I region; other site 691437007221 G2 box; other site 691437007222 G3 box; other site 691437007223 Switch II region; other site 691437007224 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 691437007225 Catalytic domain of Protein Kinases; Region: PKc; cd00180 691437007226 active site 691437007227 ATP binding site [chemical binding]; other site 691437007228 substrate binding site [chemical binding]; other site 691437007229 activation loop (A-loop); other site 691437007230 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 691437007231 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 691437007232 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 691437007233 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 691437007234 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 691437007235 Protein phosphatase 2C; Region: PP2C; pfam00481 691437007236 active site 691437007237 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 691437007238 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 691437007239 FeS/SAM binding site; other site 691437007240 16S rRNA methyltransferase B; Provisional; Region: PRK14902 691437007241 NusB family; Region: NusB; pfam01029 691437007242 putative RNA binding site [nucleotide binding]; other site 691437007243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437007244 S-adenosylmethionine binding site [chemical binding]; other site 691437007245 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 691437007246 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 691437007247 putative active site [active] 691437007248 substrate binding site [chemical binding]; other site 691437007249 putative cosubstrate binding site; other site 691437007250 catalytic site [active] 691437007251 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 691437007252 substrate binding site [chemical binding]; other site 691437007253 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 691437007254 active site 691437007255 catalytic residues [active] 691437007256 metal binding site [ion binding]; metal-binding site 691437007257 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 691437007258 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 691437007259 ATP binding site [chemical binding]; other site 691437007260 putative Mg++ binding site [ion binding]; other site 691437007261 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 691437007262 nucleotide binding region [chemical binding]; other site 691437007263 ATP-binding site [chemical binding]; other site 691437007264 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 691437007265 Flavoprotein; Region: Flavoprotein; pfam02441 691437007266 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 691437007267 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 691437007268 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 691437007269 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 691437007270 catalytic site [active] 691437007271 G-X2-G-X-G-K; other site 691437007272 hypothetical protein; Provisional; Region: PRK04323 691437007273 hypothetical protein; Provisional; Region: PRK11820 691437007274 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 691437007275 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 691437007276 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 691437007277 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 691437007278 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 691437007279 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 691437007280 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 691437007281 motif II; other site 691437007282 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 691437007283 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 691437007284 Domain of unknown function (DUF814); Region: DUF814; pfam05670 691437007285 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 691437007286 putative active site [active] 691437007287 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 691437007288 putative active site [active] 691437007289 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 691437007290 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 691437007291 catalytic residue [active] 691437007292 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 691437007293 extended (e) SDRs; Region: SDR_e; cd08946 691437007294 NAD(P) binding site [chemical binding]; other site 691437007295 active site 691437007296 substrate binding site [chemical binding]; other site 691437007297 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 691437007298 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 691437007299 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 691437007300 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 691437007301 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 691437007302 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 691437007303 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 691437007304 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 691437007305 Transposase [DNA replication, recombination, and repair]; Region: COG5421 691437007306 beta-phosphoglucomutase; Region: bPGM; TIGR01990 691437007307 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 691437007308 H+ Antiporter protein; Region: 2A0121; TIGR00900 691437007309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437007310 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 691437007311 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 691437007312 Coenzyme A binding pocket [chemical binding]; other site 691437007313 hypothetical protein; Provisional; Region: PRK07206 691437007314 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 691437007315 Protein of unknown function, DUF482; Region: DUF482; pfam04339 691437007316 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 691437007317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437007318 homodimer interface [polypeptide binding]; other site 691437007319 catalytic residue [active] 691437007320 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 691437007321 Coenzyme A binding pocket [chemical binding]; other site 691437007322 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 691437007323 active site 691437007324 nucleotide binding site [chemical binding]; other site 691437007325 HIGH motif; other site 691437007326 KMSKS motif; other site 691437007327 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 691437007328 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 691437007329 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 691437007330 catalytic residue [active] 691437007331 Transposase domain (DUF772); Region: DUF772; pfam05598 691437007332 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 691437007333 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 691437007334 H+ Antiporter protein; Region: 2A0121; TIGR00900 691437007335 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437007336 putative substrate translocation pore; other site 691437007337 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 691437007338 Transposase; Region: DDE_Tnp_ISL3; pfam01610 691437007339 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 691437007340 active site 691437007341 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 691437007342 active site 691437007343 dimer interface [polypeptide binding]; other site 691437007344 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 691437007345 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 691437007346 heterodimer interface [polypeptide binding]; other site 691437007347 active site 691437007348 FMN binding site [chemical binding]; other site 691437007349 homodimer interface [polypeptide binding]; other site 691437007350 substrate binding site [chemical binding]; other site 691437007351 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 691437007352 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 691437007353 FAD binding pocket [chemical binding]; other site 691437007354 FAD binding motif [chemical binding]; other site 691437007355 phosphate binding motif [ion binding]; other site 691437007356 beta-alpha-beta structure motif; other site 691437007357 NAD binding pocket [chemical binding]; other site 691437007358 Iron coordination center [ion binding]; other site 691437007359 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 691437007360 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 691437007361 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 691437007362 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 691437007363 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 691437007364 ATP-grasp domain; Region: ATP-grasp_4; cl17255 691437007365 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 691437007366 IMP binding site; other site 691437007367 dimer interface [polypeptide binding]; other site 691437007368 interdomain contacts; other site 691437007369 partial ornithine binding site; other site 691437007370 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 691437007371 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 691437007372 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 691437007373 catalytic site [active] 691437007374 subunit interface [polypeptide binding]; other site 691437007375 dihydroorotase; Validated; Region: pyrC; PRK09357 691437007376 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 691437007377 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 691437007378 active site 691437007379 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 691437007380 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 691437007381 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 691437007382 uracil-xanthine permease; Region: ncs2; TIGR00801 691437007383 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 691437007384 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 691437007385 active site 691437007386 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 691437007387 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 691437007388 RNA binding surface [nucleotide binding]; other site 691437007389 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 691437007390 active site 691437007391 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 691437007392 lipoprotein signal peptidase; Provisional; Region: PRK14787 691437007393 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 691437007394 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 691437007395 HIGH motif; other site 691437007396 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 691437007397 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 691437007398 active site 691437007399 KMSKS motif; other site 691437007400 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 691437007401 tRNA binding surface [nucleotide binding]; other site 691437007402 anticodon binding site; other site 691437007403 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 691437007404 DivIVA protein; Region: DivIVA; pfam05103 691437007405 DivIVA domain; Region: DivI1A_domain; TIGR03544 691437007406 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 691437007407 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 691437007408 RNA binding surface [nucleotide binding]; other site 691437007409 YGGT family; Region: YGGT; pfam02325 691437007410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 691437007411 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 691437007412 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 691437007413 catalytic residue [active] 691437007414 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 691437007415 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 691437007416 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 691437007417 sporulation sigma factor SigG; Reviewed; Region: PRK08215 691437007418 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 691437007419 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 691437007420 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 691437007421 DNA binding residues [nucleotide binding] 691437007422 sporulation sigma factor SigE; Reviewed; Region: PRK08301 691437007423 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 691437007424 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 691437007425 DNA binding residues [nucleotide binding] 691437007426 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 691437007427 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 691437007428 cell division protein FtsZ; Validated; Region: PRK09330 691437007429 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 691437007430 nucleotide binding site [chemical binding]; other site 691437007431 SulA interaction site; other site 691437007432 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 691437007433 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 691437007434 nucleotide binding site [chemical binding]; other site 691437007435 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 691437007436 Cell division protein FtsA; Region: FtsA; pfam14450 691437007437 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 691437007438 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 691437007439 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 691437007440 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 691437007441 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 691437007442 Cell division protein FtsQ; Region: FtsQ; pfam03799 691437007443 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 691437007444 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 691437007445 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 691437007446 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 691437007447 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 691437007448 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 691437007449 Mg++ binding site [ion binding]; other site 691437007450 putative catalytic motif [active] 691437007451 putative substrate binding site [chemical binding]; other site 691437007452 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 691437007453 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 691437007454 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 691437007455 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 691437007456 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 691437007457 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 691437007458 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 691437007459 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 691437007460 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 691437007461 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 691437007462 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 691437007463 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 691437007464 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 691437007465 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 691437007466 MraW methylase family; Region: Methyltransf_5; pfam01795 691437007467 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 691437007468 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 691437007469 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 691437007470 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 691437007471 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 691437007472 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 691437007473 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 691437007474 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 691437007475 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 691437007476 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 691437007477 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 691437007478 substrate binding site [chemical binding]; other site 691437007479 oxyanion hole (OAH) forming residues; other site 691437007480 trimer interface [polypeptide binding]; other site 691437007481 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 691437007482 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 691437007483 hypothetical protein; Provisional; Region: PRK13670 691437007484 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 691437007485 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 691437007486 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 691437007487 protein binding site [polypeptide binding]; other site 691437007488 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 691437007489 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 691437007490 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 691437007491 active site 691437007492 nucleophile elbow; other site 691437007493 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 691437007494 Nucleoside recognition; Region: Gate; pfam07670 691437007495 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 691437007496 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 691437007497 active site 691437007498 (T/H)XGH motif; other site 691437007499 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 691437007500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437007501 S-adenosylmethionine binding site [chemical binding]; other site 691437007502 hypothetical protein; Provisional; Region: PRK02886 691437007503 Protein of unknown function (DUF964); Region: DUF964; pfam06133 691437007504 YlbE-like protein; Region: YlbE; pfam14003 691437007505 Putative coat protein; Region: YlbD_coat; pfam14071 691437007506 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 691437007507 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 691437007508 FOG: CBS domain [General function prediction only]; Region: COG0517 691437007509 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 691437007510 YugN-like family; Region: YugN; pfam08868 691437007511 Asp23 family; Region: Asp23; cl00574 691437007512 Protein of unknown function (DUF420); Region: DUF420; pfam04238 691437007513 cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737 691437007514 cytochrome c oxidase, subunit IVB; Region: CoxD_Bacillus; TIGR02908 691437007515 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 691437007516 Subunit I/III interface [polypeptide binding]; other site 691437007517 Subunit III/IV interface [polypeptide binding]; other site 691437007518 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 691437007519 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 691437007520 D-pathway; other site 691437007521 Putative ubiquinol binding site [chemical binding]; other site 691437007522 Low-spin heme (heme b) binding site [chemical binding]; other site 691437007523 Putative water exit pathway; other site 691437007524 Binuclear center (heme o3/CuB) [ion binding]; other site 691437007525 K-pathway; other site 691437007526 Putative proton exit pathway; other site 691437007527 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 691437007528 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 691437007529 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 691437007530 Cytochrome c; Region: Cytochrom_C; pfam00034 691437007531 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 691437007532 UbiA prenyltransferase family; Region: UbiA; pfam01040 691437007533 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 691437007534 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 691437007535 pyruvate carboxylase; Reviewed; Region: PRK12999 691437007536 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 691437007537 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 691437007538 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 691437007539 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 691437007540 active site 691437007541 catalytic residues [active] 691437007542 metal binding site [ion binding]; metal-binding site 691437007543 homodimer binding site [polypeptide binding]; other site 691437007544 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 691437007545 carboxyltransferase (CT) interaction site; other site 691437007546 biotinylation site [posttranslational modification]; other site 691437007547 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 691437007548 hypothetical protein; Provisional; Region: PRK13666 691437007549 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 691437007550 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 691437007551 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 691437007552 putative active site [active] 691437007553 PhoH-like protein; Region: PhoH; pfam02562 691437007554 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 691437007555 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 691437007556 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 691437007557 YlaH-like protein; Region: YlaH; pfam14036 691437007558 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 691437007559 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 691437007560 G1 box; other site 691437007561 putative GEF interaction site [polypeptide binding]; other site 691437007562 GTP/Mg2+ binding site [chemical binding]; other site 691437007563 Switch I region; other site 691437007564 G2 box; other site 691437007565 G3 box; other site 691437007566 Switch II region; other site 691437007567 G4 box; other site 691437007568 G5 box; other site 691437007569 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 691437007570 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 691437007571 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 691437007572 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 691437007573 active site 691437007574 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 691437007575 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 691437007576 FMN binding site [chemical binding]; other site 691437007577 substrate binding site [chemical binding]; other site 691437007578 putative catalytic residue [active] 691437007579 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 691437007580 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 691437007581 homodimer interface [polypeptide binding]; other site 691437007582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437007583 catalytic residue [active] 691437007584 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 691437007585 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 691437007586 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 691437007587 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 691437007588 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 691437007589 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 691437007590 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 691437007591 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 691437007592 E3 interaction surface; other site 691437007593 lipoyl attachment site [posttranslational modification]; other site 691437007594 e3 binding domain; Region: E3_binding; pfam02817 691437007595 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 691437007596 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 691437007597 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 691437007598 alpha subunit interface [polypeptide binding]; other site 691437007599 TPP binding site [chemical binding]; other site 691437007600 heterodimer interface [polypeptide binding]; other site 691437007601 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 691437007602 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 691437007603 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 691437007604 TPP-binding site [chemical binding]; other site 691437007605 tetramer interface [polypeptide binding]; other site 691437007606 heterodimer interface [polypeptide binding]; other site 691437007607 phosphorylation loop region [posttranslational modification] 691437007608 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 691437007609 active site 691437007610 catalytic residues [active] 691437007611 metal binding site [ion binding]; metal-binding site 691437007612 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 691437007613 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 691437007614 active site 691437007615 motif I; other site 691437007616 motif II; other site 691437007617 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 691437007618 motif II; other site 691437007619 hypothetical protein; Provisional; Region: PRK13667 691437007620 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 691437007621 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 691437007622 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 691437007623 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 691437007624 TrkA-N domain; Region: TrkA_N; pfam02254 691437007625 TrkA-C domain; Region: TrkA_C; pfam02080 691437007626 hypothetical protein; Provisional; Region: PRK03094 691437007627 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 691437007628 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 691437007629 metal binding site [ion binding]; metal-binding site 691437007630 putative dimer interface [polypeptide binding]; other site 691437007631 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 691437007632 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 691437007633 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 691437007634 active site 691437007635 trimer interface [polypeptide binding]; other site 691437007636 substrate binding site [chemical binding]; other site 691437007637 CoA binding site [chemical binding]; other site 691437007638 FOG: CBS domain [General function prediction only]; Region: COG0517 691437007639 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 691437007640 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 691437007641 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 691437007642 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 691437007643 short chain dehydrogenase; Provisional; Region: PRK07677 691437007644 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 691437007645 NAD(P) binding site [chemical binding]; other site 691437007646 substrate binding site [chemical binding]; other site 691437007647 homotetramer interface [polypeptide binding]; other site 691437007648 active site 691437007649 homodimer interface [polypeptide binding]; other site 691437007650 phosphodiesterase YaeI; Provisional; Region: PRK11340 691437007651 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 691437007652 putative active site [active] 691437007653 putative metal binding site [ion binding]; other site 691437007654 YkyB-like protein; Region: YkyB; pfam14177 691437007655 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 691437007656 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 691437007657 DXD motif; other site 691437007658 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 691437007659 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 691437007660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 691437007661 active site 691437007662 phosphorylation site [posttranslational modification] 691437007663 dimerization interface [polypeptide binding]; other site 691437007664 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 691437007665 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 691437007666 metal binding site [ion binding]; metal-binding site 691437007667 active site 691437007668 I-site; other site 691437007669 Response regulator receiver domain; Region: Response_reg; pfam00072 691437007670 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437007671 active site 691437007672 phosphorylation site [posttranslational modification] 691437007673 intermolecular recognition site; other site 691437007674 dimerization interface [polypeptide binding]; other site 691437007675 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 691437007676 active site 691437007677 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 691437007678 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 691437007679 oligomer interface [polypeptide binding]; other site 691437007680 metal binding site [ion binding]; metal-binding site 691437007681 metal binding site [ion binding]; metal-binding site 691437007682 putative Cl binding site [ion binding]; other site 691437007683 aspartate ring; other site 691437007684 basic sphincter; other site 691437007685 hydrophobic gate; other site 691437007686 periplasmic entrance; other site 691437007687 A short protein domain of unknown function; Region: IDEAL; smart00914 691437007688 aminotransferase A; Validated; Region: PRK07683 691437007689 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 691437007690 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437007691 homodimer interface [polypeptide binding]; other site 691437007692 catalytic residue [active] 691437007693 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 691437007694 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 691437007695 NAD(P) binding site [chemical binding]; other site 691437007696 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 691437007697 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 691437007698 Phosphotransferase enzyme family; Region: APH; pfam01636 691437007699 putative active site [active] 691437007700 putative substrate binding site [chemical binding]; other site 691437007701 ATP binding site [chemical binding]; other site 691437007702 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 691437007703 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 691437007704 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 691437007705 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 691437007706 acyl-activating enzyme (AAE) consensus motif; other site 691437007707 putative AMP binding site [chemical binding]; other site 691437007708 putative active site [active] 691437007709 putative CoA binding site [chemical binding]; other site 691437007710 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 691437007711 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437007712 NAD(P) binding site [chemical binding]; other site 691437007713 active site 691437007714 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 691437007715 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 691437007716 FAD binding site [chemical binding]; other site 691437007717 substrate binding site [chemical binding]; other site 691437007718 catalytic base [active] 691437007719 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 691437007720 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 691437007721 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 691437007722 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 691437007723 putative NAD(P) binding site [chemical binding]; other site 691437007724 putative active site [active] 691437007725 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 691437007726 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 691437007727 E3 interaction surface; other site 691437007728 lipoyl attachment site [posttranslational modification]; other site 691437007729 e3 binding domain; Region: E3_binding; pfam02817 691437007730 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 691437007731 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 691437007732 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 691437007733 TPP-binding site [chemical binding]; other site 691437007734 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 691437007735 Cache domain; Region: Cache_1; pfam02743 691437007736 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 691437007737 dimerization interface [polypeptide binding]; other site 691437007738 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 691437007739 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 691437007740 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 691437007741 dimer interface [polypeptide binding]; other site 691437007742 putative CheW interface [polypeptide binding]; other site 691437007743 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 691437007744 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 691437007745 Coenzyme A binding pocket [chemical binding]; other site 691437007746 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 691437007747 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 691437007748 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 691437007749 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 691437007750 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 691437007751 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 691437007752 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 691437007753 dimerization domain swap beta strand [polypeptide binding]; other site 691437007754 regulatory protein interface [polypeptide binding]; other site 691437007755 active site 691437007756 regulatory phosphorylation site [posttranslational modification]; other site 691437007757 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 691437007758 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 691437007759 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 691437007760 active site turn [active] 691437007761 phosphorylation site [posttranslational modification] 691437007762 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 691437007763 HPr interaction site; other site 691437007764 glycerol kinase (GK) interaction site [polypeptide binding]; other site 691437007765 active site 691437007766 phosphorylation site [posttranslational modification] 691437007767 transcriptional antiterminator BglG; Provisional; Region: PRK09772 691437007768 CAT RNA binding domain; Region: CAT_RBD; smart01061 691437007769 PRD domain; Region: PRD; pfam00874 691437007770 PRD domain; Region: PRD; pfam00874 691437007771 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 691437007772 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 691437007773 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 691437007774 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 691437007775 putative active site [active] 691437007776 heme pocket [chemical binding]; other site 691437007777 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437007778 dimer interface [polypeptide binding]; other site 691437007779 phosphorylation site [posttranslational modification] 691437007780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437007781 ATP binding site [chemical binding]; other site 691437007782 Mg2+ binding site [ion binding]; other site 691437007783 G-X-G motif; other site 691437007784 YueH-like protein; Region: YueH; pfam14166 691437007785 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437007786 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 691437007787 NAD(P) binding site [chemical binding]; other site 691437007788 active site 691437007789 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 691437007790 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 691437007791 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 691437007792 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953 691437007793 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 691437007794 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 691437007795 NAD binding site [chemical binding]; other site 691437007796 active site 691437007797 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 691437007798 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 691437007799 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 691437007800 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 691437007801 active site 691437007802 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 691437007803 Ligand Binding Site [chemical binding]; other site 691437007804 Spore germination protein; Region: Spore_permease; pfam03845 691437007805 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 691437007806 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 691437007807 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 691437007808 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 691437007809 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 691437007810 dimer interface [polypeptide binding]; other site 691437007811 putative CheW interface [polypeptide binding]; other site 691437007812 Uncharacterized membrane protein [Function unknown]; Region: COG3949 691437007813 YtkA-like; Region: YtkA; pfam13115 691437007814 YtkA-like; Region: YtkA; pfam13115 691437007815 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437007816 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 691437007817 Walker A motif; other site 691437007818 ATP binding site [chemical binding]; other site 691437007819 Walker B motif; other site 691437007820 arginine finger; other site 691437007821 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437007822 Walker A motif; other site 691437007823 ATP binding site [chemical binding]; other site 691437007824 Walker B motif; other site 691437007825 arginine finger; other site 691437007826 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 691437007827 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 691437007828 active site 691437007829 NTP binding site [chemical binding]; other site 691437007830 metal binding triad [ion binding]; metal-binding site 691437007831 antibiotic binding site [chemical binding]; other site 691437007832 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 691437007833 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 691437007834 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 691437007835 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 691437007836 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 691437007837 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 691437007838 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 691437007839 Walker A/P-loop; other site 691437007840 ATP binding site [chemical binding]; other site 691437007841 Q-loop/lid; other site 691437007842 ABC transporter signature motif; other site 691437007843 Walker B; other site 691437007844 D-loop; other site 691437007845 H-loop/switch region; other site 691437007846 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 691437007847 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 691437007848 Coenzyme A binding pocket [chemical binding]; other site 691437007849 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 691437007850 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 691437007851 active site 691437007852 Zn binding site [ion binding]; other site 691437007853 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 691437007854 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 691437007855 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 691437007856 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 691437007857 short chain dehydrogenase; Provisional; Region: PRK08309 691437007858 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 691437007859 Propanediol utilisation protein PduL; Region: PduL; pfam06130 691437007860 Propanediol utilisation protein PduL; Region: PduL; pfam06130 691437007861 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 691437007862 MarR family; Region: MarR; pfam01047 691437007863 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 691437007864 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 691437007865 Cupin domain; Region: Cupin_2; cl17218 691437007866 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 691437007867 intersubunit interface [polypeptide binding]; other site 691437007868 active site 691437007869 Zn2+ binding site [ion binding]; other site 691437007870 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 691437007871 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 691437007872 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 691437007873 motif II; other site 691437007874 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 691437007875 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 691437007876 dimer interface [polypeptide binding]; other site 691437007877 active site 691437007878 catalytic residue [active] 691437007879 metal binding site [ion binding]; metal-binding site 691437007880 transaminase; Reviewed; Region: PRK08068 691437007881 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 691437007882 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437007883 homodimer interface [polypeptide binding]; other site 691437007884 catalytic residue [active] 691437007885 Predicted amidohydrolase [General function prediction only]; Region: COG0388 691437007886 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 691437007887 putative active site [active] 691437007888 catalytic triad [active] 691437007889 putative dimer interface [polypeptide binding]; other site 691437007890 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 691437007891 Phosphotransferase enzyme family; Region: APH; pfam01636 691437007892 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 691437007893 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 691437007894 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 691437007895 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 691437007896 putative ligand binding site [chemical binding]; other site 691437007897 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 691437007898 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 691437007899 Walker A/P-loop; other site 691437007900 ATP binding site [chemical binding]; other site 691437007901 Q-loop/lid; other site 691437007902 ABC transporter signature motif; other site 691437007903 Walker B; other site 691437007904 D-loop; other site 691437007905 H-loop/switch region; other site 691437007906 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 691437007907 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 691437007908 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 691437007909 TM-ABC transporter signature motif; other site 691437007910 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 691437007911 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 691437007912 DNA binding site [nucleotide binding] 691437007913 active site 691437007914 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 691437007915 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 691437007916 putative active site [active] 691437007917 heme pocket [chemical binding]; other site 691437007918 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 691437007919 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 691437007920 putative active site [active] 691437007921 heme pocket [chemical binding]; other site 691437007922 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 691437007923 putative active site [active] 691437007924 heme pocket [chemical binding]; other site 691437007925 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 691437007926 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 691437007927 putative active site [active] 691437007928 heme pocket [chemical binding]; other site 691437007929 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437007930 dimer interface [polypeptide binding]; other site 691437007931 phosphorylation site [posttranslational modification] 691437007932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437007933 ATP binding site [chemical binding]; other site 691437007934 Mg2+ binding site [ion binding]; other site 691437007935 G-X-G motif; other site 691437007936 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 691437007937 Radical SAM superfamily; Region: Radical_SAM; pfam04055 691437007938 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 691437007939 FeS/SAM binding site; other site 691437007940 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 691437007941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437007942 Major Facilitator Superfamily; Region: MFS_1; pfam07690 691437007943 putative substrate translocation pore; other site 691437007944 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 691437007945 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437007946 dimer interface [polypeptide binding]; other site 691437007947 conserved gate region; other site 691437007948 putative PBP binding loops; other site 691437007949 ABC-ATPase subunit interface; other site 691437007950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437007951 dimer interface [polypeptide binding]; other site 691437007952 conserved gate region; other site 691437007953 putative PBP binding loops; other site 691437007954 ABC-ATPase subunit interface; other site 691437007955 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 691437007956 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 691437007957 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 691437007958 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 691437007959 Transcriptional regulators [Transcription]; Region: PurR; COG1609 691437007960 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 691437007961 DNA binding site [nucleotide binding] 691437007962 domain linker motif; other site 691437007963 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 691437007964 dimerization interface [polypeptide binding]; other site 691437007965 ligand binding site [chemical binding]; other site 691437007966 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 691437007967 amino acid transporter; Region: 2A0306; TIGR00909 691437007968 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 691437007969 Protein of unknown function, DUF485; Region: DUF485; pfam04341 691437007970 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 691437007971 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 691437007972 Na binding site [ion binding]; other site 691437007973 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 691437007974 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 691437007975 Coenzyme A binding pocket [chemical binding]; other site 691437007976 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 691437007977 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 691437007978 active site 691437007979 octamer interface [polypeptide binding]; other site 691437007980 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 691437007981 Coenzyme A binding pocket [chemical binding]; other site 691437007982 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 691437007983 amidohydrolase; Region: amidohydrolases; TIGR01891 691437007984 metal binding site [ion binding]; metal-binding site 691437007985 putative dimer interface [polypeptide binding]; other site 691437007986 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 691437007987 Uncharacterized conserved protein [Function unknown]; Region: COG2966 691437007988 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 691437007989 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 691437007990 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 691437007991 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 691437007992 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 691437007993 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 691437007994 FAD binding domain; Region: FAD_binding_4; pfam01565 691437007995 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 691437007996 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 691437007997 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 691437007998 Zn2+ binding site [ion binding]; other site 691437007999 Mg2+ binding site [ion binding]; other site 691437008000 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 691437008001 putative active site pocket [active] 691437008002 dimerization interface [polypeptide binding]; other site 691437008003 putative catalytic residue [active] 691437008004 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 691437008005 putative active site pocket [active] 691437008006 dimerization interface [polypeptide binding]; other site 691437008007 putative catalytic residue [active] 691437008008 TPR repeat; Region: TPR_11; pfam13414 691437008009 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 691437008010 TPR motif; other site 691437008011 Tetratricopeptide repeat; Region: TPR_12; pfam13424 691437008012 binding surface 691437008013 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 691437008014 dimer interface [polypeptide binding]; other site 691437008015 putative radical transfer pathway; other site 691437008016 diiron center [ion binding]; other site 691437008017 tyrosyl radical; other site 691437008018 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 691437008019 Class I ribonucleotide reductase; Region: RNR_I; cd01679 691437008020 active site 691437008021 dimer interface [polypeptide binding]; other site 691437008022 catalytic residues [active] 691437008023 effector binding site; other site 691437008024 R2 peptide binding site; other site 691437008025 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 691437008026 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 691437008027 Walker A/P-loop; other site 691437008028 ATP binding site [chemical binding]; other site 691437008029 Q-loop/lid; other site 691437008030 ABC transporter signature motif; other site 691437008031 Walker B; other site 691437008032 D-loop; other site 691437008033 H-loop/switch region; other site 691437008034 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 691437008035 ABC-2 type transporter; Region: ABC2_membrane; cl17235 691437008036 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 691437008037 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 691437008038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437008039 active site 691437008040 phosphorylation site [posttranslational modification] 691437008041 intermolecular recognition site; other site 691437008042 dimerization interface [polypeptide binding]; other site 691437008043 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 691437008044 DNA binding site [nucleotide binding] 691437008045 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 691437008046 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437008047 dimer interface [polypeptide binding]; other site 691437008048 phosphorylation site [posttranslational modification] 691437008049 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437008050 ATP binding site [chemical binding]; other site 691437008051 Mg2+ binding site [ion binding]; other site 691437008052 G-X-G motif; other site 691437008053 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 691437008054 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 691437008055 active site 691437008056 dimer interface [polypeptide binding]; other site 691437008057 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 691437008058 Ligand Binding Site [chemical binding]; other site 691437008059 Molecular Tunnel; other site 691437008060 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 691437008061 putative active site [active] 691437008062 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 691437008063 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 691437008064 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 691437008065 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 691437008066 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 691437008067 active site 691437008068 NTP binding site [chemical binding]; other site 691437008069 metal binding triad [ion binding]; metal-binding site 691437008070 antibiotic binding site [chemical binding]; other site 691437008071 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 691437008072 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 691437008073 metal-binding site [ion binding] 691437008074 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 691437008075 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 691437008076 metal-binding site [ion binding] 691437008077 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 691437008078 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 691437008079 metal-binding site [ion binding] 691437008080 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 691437008081 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 691437008082 motif II; other site 691437008083 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 691437008084 putative homodimer interface [polypeptide binding]; other site 691437008085 putative homotetramer interface [polypeptide binding]; other site 691437008086 putative allosteric switch controlling residues; other site 691437008087 putative metal binding site [ion binding]; other site 691437008088 putative homodimer-homodimer interface [polypeptide binding]; other site 691437008089 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 691437008090 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 691437008091 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 691437008092 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 691437008093 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 691437008094 beta-galactosidase; Region: BGL; TIGR03356 691437008095 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 691437008096 Transcriptional regulator [Transcription]; Region: LysR; COG0583 691437008097 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 691437008098 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 691437008099 putative dimerization interface [polypeptide binding]; other site 691437008100 Predicted membrane protein [Function unknown]; Region: COG2855 691437008101 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 691437008102 Predicted membrane protein [Function unknown]; Region: COG2261 691437008103 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 691437008104 dimerization interface [polypeptide binding]; other site 691437008105 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 691437008106 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 691437008107 dimer interface [polypeptide binding]; other site 691437008108 putative CheW interface [polypeptide binding]; other site 691437008109 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 691437008110 active site 691437008111 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 691437008112 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 691437008113 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 691437008114 HsdM N-terminal domain; Region: HsdM_N; pfam12161 691437008115 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 691437008116 Methyltransferase domain; Region: Methyltransf_26; pfam13659 691437008117 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 691437008118 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 691437008119 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 691437008120 ATP binding site [chemical binding]; other site 691437008121 putative Mg++ binding site [ion binding]; other site 691437008122 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 691437008123 AAA domain; Region: AAA_18; pfam13238 691437008124 active site 691437008125 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 691437008126 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 691437008127 Zn2+ binding site [ion binding]; other site 691437008128 Mg2+ binding site [ion binding]; other site 691437008129 cystathionine beta-lyase; Provisional; Region: PRK08064 691437008130 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 691437008131 homodimer interface [polypeptide binding]; other site 691437008132 substrate-cofactor binding pocket; other site 691437008133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437008134 catalytic residue [active] 691437008135 cystathionine gamma-synthase; Reviewed; Region: PRK08247 691437008136 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 691437008137 homodimer interface [polypeptide binding]; other site 691437008138 substrate-cofactor binding pocket; other site 691437008139 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437008140 catalytic residue [active] 691437008141 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 691437008142 Putative esterase; Region: Esterase; pfam00756 691437008143 hypothetical protein; Provisional; Region: PRK13679 691437008144 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 691437008145 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 691437008146 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 691437008147 Coenzyme A binding pocket [chemical binding]; other site 691437008148 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 691437008149 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 691437008150 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 691437008151 catalytic residues [active] 691437008152 Predicted membrane protein [Function unknown]; Region: COG2323 691437008153 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 691437008154 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 691437008155 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 691437008156 stage V sporulation protein AD; Provisional; Region: PRK12404 691437008157 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 691437008158 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 691437008159 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 691437008160 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 691437008161 Bacteriophage holin; Region: Phage_holin_1; cl02344 691437008162 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 691437008163 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 691437008164 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 691437008165 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 691437008166 active site 691437008167 ATP binding site [chemical binding]; other site 691437008168 substrate binding site [chemical binding]; other site 691437008169 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 691437008170 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 691437008171 putative ADP-binding pocket [chemical binding]; other site 691437008172 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 691437008173 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 691437008174 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 691437008175 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 691437008176 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 691437008177 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437008178 NAD(P) binding site [chemical binding]; other site 691437008179 active site 691437008180 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 691437008181 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 691437008182 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 691437008183 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 691437008184 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 691437008185 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 691437008186 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 691437008187 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 691437008188 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 691437008189 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 691437008190 NAD binding site [chemical binding]; other site 691437008191 homotetramer interface [polypeptide binding]; other site 691437008192 homodimer interface [polypeptide binding]; other site 691437008193 substrate binding site [chemical binding]; other site 691437008194 active site 691437008195 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 691437008196 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 691437008197 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 691437008198 active site 691437008199 metal binding site [ion binding]; metal-binding site 691437008200 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 691437008201 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 691437008202 active site 691437008203 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 691437008204 ATP-NAD kinase; Region: NAD_kinase; pfam01513 691437008205 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 691437008206 synthetase active site [active] 691437008207 NTP binding site [chemical binding]; other site 691437008208 metal binding site [ion binding]; metal-binding site 691437008209 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 691437008210 putative active site [active] 691437008211 putative metal binding residues [ion binding]; other site 691437008212 signature motif; other site 691437008213 putative triphosphate binding site [ion binding]; other site 691437008214 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 691437008215 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 691437008216 N-acetyl-D-glucosamine binding site [chemical binding]; other site 691437008217 catalytic residue [active] 691437008218 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 691437008219 apolar tunnel; other site 691437008220 heme binding site [chemical binding]; other site 691437008221 dimerization interface [polypeptide binding]; other site 691437008222 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 691437008223 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 691437008224 catalytic residues [active] 691437008225 oligoendopeptidase F; Region: pepF; TIGR00181 691437008226 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 691437008227 active site 691437008228 Zn binding site [ion binding]; other site 691437008229 Competence protein CoiA-like family; Region: CoiA; cl11541 691437008230 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 691437008231 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 691437008232 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 691437008233 putative active site [active] 691437008234 catalytic site [active] 691437008235 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 691437008236 putative active site [active] 691437008237 catalytic site [active] 691437008238 adaptor protein; Provisional; Region: PRK02315 691437008239 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 691437008240 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 691437008241 ArsC family; Region: ArsC; pfam03960 691437008242 putative catalytic residues [active] 691437008243 thiol/disulfide switch; other site 691437008244 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 691437008245 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 691437008246 Walker A/P-loop; other site 691437008247 ATP binding site [chemical binding]; other site 691437008248 Q-loop/lid; other site 691437008249 ABC transporter signature motif; other site 691437008250 Walker B; other site 691437008251 D-loop; other site 691437008252 H-loop/switch region; other site 691437008253 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 691437008254 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 691437008255 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 691437008256 Walker A/P-loop; other site 691437008257 ATP binding site [chemical binding]; other site 691437008258 Q-loop/lid; other site 691437008259 ABC transporter signature motif; other site 691437008260 Walker B; other site 691437008261 D-loop; other site 691437008262 H-loop/switch region; other site 691437008263 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 691437008264 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 691437008265 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 691437008266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437008267 dimer interface [polypeptide binding]; other site 691437008268 conserved gate region; other site 691437008269 putative PBP binding loops; other site 691437008270 ABC-ATPase subunit interface; other site 691437008271 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 691437008272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437008273 dimer interface [polypeptide binding]; other site 691437008274 conserved gate region; other site 691437008275 putative PBP binding loops; other site 691437008276 ABC-ATPase subunit interface; other site 691437008277 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 691437008278 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 691437008279 peptide binding site [polypeptide binding]; other site 691437008280 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 691437008281 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 691437008282 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 691437008283 active site 691437008284 HIGH motif; other site 691437008285 dimer interface [polypeptide binding]; other site 691437008286 KMSKS motif; other site 691437008287 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 691437008288 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 691437008289 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 691437008290 dimer interface [polypeptide binding]; other site 691437008291 active site 691437008292 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 691437008293 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 691437008294 dimer interface [polypeptide binding]; other site 691437008295 active site 691437008296 CoA binding pocket [chemical binding]; other site 691437008297 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 691437008298 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 691437008299 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 691437008300 Clp amino terminal domain; Region: Clp_N; pfam02861 691437008301 Clp amino terminal domain; Region: Clp_N; pfam02861 691437008302 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437008303 Walker A motif; other site 691437008304 ATP binding site [chemical binding]; other site 691437008305 Walker B motif; other site 691437008306 arginine finger; other site 691437008307 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437008308 Walker A motif; other site 691437008309 ATP binding site [chemical binding]; other site 691437008310 Walker B motif; other site 691437008311 arginine finger; other site 691437008312 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 691437008313 YjzC-like protein; Region: YjzC; pfam14168 691437008314 ornithine carbamoyltransferase; Provisional; Region: PRK00779 691437008315 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 691437008316 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 691437008317 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 691437008318 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 691437008319 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 691437008320 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 691437008321 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 691437008322 ATP-grasp domain; Region: ATP-grasp_4; cl17255 691437008323 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 691437008324 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 691437008325 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 691437008326 catalytic site [active] 691437008327 subunit interface [polypeptide binding]; other site 691437008328 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 691437008329 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 691437008330 inhibitor-cofactor binding pocket; inhibition site 691437008331 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437008332 catalytic residue [active] 691437008333 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 691437008334 nucleotide binding site [chemical binding]; other site 691437008335 N-acetyl-L-glutamate binding site [chemical binding]; other site 691437008336 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 691437008337 heterotetramer interface [polypeptide binding]; other site 691437008338 active site pocket [active] 691437008339 cleavage site 691437008340 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 691437008341 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 691437008342 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 691437008343 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 691437008344 ligand binding site [chemical binding]; other site 691437008345 flexible hinge region; other site 691437008346 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 691437008347 putative switch regulator; other site 691437008348 non-specific DNA interactions [nucleotide binding]; other site 691437008349 DNA binding site [nucleotide binding] 691437008350 sequence specific DNA binding site [nucleotide binding]; other site 691437008351 putative cAMP binding site [chemical binding]; other site 691437008352 YwiC-like protein; Region: YwiC; pfam14256 691437008353 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 691437008354 MoaE interaction surface [polypeptide binding]; other site 691437008355 MoeB interaction surface [polypeptide binding]; other site 691437008356 thiocarboxylated glycine; other site 691437008357 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 691437008358 MoaE homodimer interface [polypeptide binding]; other site 691437008359 MoaD interaction [polypeptide binding]; other site 691437008360 active site residues [active] 691437008361 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 691437008362 Walker A motif; other site 691437008363 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 691437008364 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 691437008365 dimer interface [polypeptide binding]; other site 691437008366 putative functional site; other site 691437008367 putative MPT binding site; other site 691437008368 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 691437008369 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 691437008370 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 691437008371 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 691437008372 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 691437008373 FeS/SAM binding site; other site 691437008374 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 691437008375 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 691437008376 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437008377 putative PBP binding loops; other site 691437008378 dimer interface [polypeptide binding]; other site 691437008379 ABC-ATPase subunit interface; other site 691437008380 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 691437008381 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 691437008382 ligand binding site [chemical binding]; other site 691437008383 flexible hinge region; other site 691437008384 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 691437008385 putative switch regulator; other site 691437008386 non-specific DNA interactions [nucleotide binding]; other site 691437008387 DNA binding site [nucleotide binding] 691437008388 sequence specific DNA binding site [nucleotide binding]; other site 691437008389 putative cAMP binding site [chemical binding]; other site 691437008390 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 691437008391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437008392 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 691437008393 putative substrate translocation pore; other site 691437008394 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 691437008395 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 691437008396 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 691437008397 Walker A/P-loop; other site 691437008398 ATP binding site [chemical binding]; other site 691437008399 Q-loop/lid; other site 691437008400 ABC transporter signature motif; other site 691437008401 Walker B; other site 691437008402 D-loop; other site 691437008403 H-loop/switch region; other site 691437008404 Predicted membrane protein [Function unknown]; Region: COG1470 691437008405 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 691437008406 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 691437008407 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 691437008408 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 691437008409 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 691437008410 DNA binding residues [nucleotide binding] 691437008411 Putative zinc-finger; Region: zf-HC2; pfam13490 691437008412 Anti-sigma-K factor rskA; Region: RskA; pfam10099 691437008413 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 691437008414 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 691437008415 FeS/SAM binding site; other site 691437008416 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 691437008417 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 691437008418 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 691437008419 Walker A/P-loop; other site 691437008420 ATP binding site [chemical binding]; other site 691437008421 Q-loop/lid; other site 691437008422 ABC transporter signature motif; other site 691437008423 Walker B; other site 691437008424 D-loop; other site 691437008425 H-loop/switch region; other site 691437008426 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 691437008427 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 691437008428 Walker A/P-loop; other site 691437008429 ATP binding site [chemical binding]; other site 691437008430 Q-loop/lid; other site 691437008431 ABC transporter signature motif; other site 691437008432 Walker B; other site 691437008433 D-loop; other site 691437008434 H-loop/switch region; other site 691437008435 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 691437008436 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437008437 active site 691437008438 phosphorylation site [posttranslational modification] 691437008439 intermolecular recognition site; other site 691437008440 dimerization interface [polypeptide binding]; other site 691437008441 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 691437008442 DNA binding residues [nucleotide binding] 691437008443 dimerization interface [polypeptide binding]; other site 691437008444 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 691437008445 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 691437008446 GTP binding site; other site 691437008447 Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719 691437008448 MAEBL; Provisional; Region: PTZ00121 691437008449 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 691437008450 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 691437008451 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 691437008452 D-pathway; other site 691437008453 Low-spin heme binding site [chemical binding]; other site 691437008454 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 691437008455 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 691437008456 ligand binding site [chemical binding]; other site 691437008457 flexible hinge region; other site 691437008458 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 691437008459 non-specific DNA interactions [nucleotide binding]; other site 691437008460 DNA binding site [nucleotide binding] 691437008461 sequence specific DNA binding site [nucleotide binding]; other site 691437008462 putative cAMP binding site [chemical binding]; other site 691437008463 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 691437008464 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 691437008465 CPxP motif; other site 691437008466 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 691437008467 Fic family protein [Function unknown]; Region: COG3177 691437008468 Fic/DOC family; Region: Fic; pfam02661 691437008469 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 691437008470 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 691437008471 metal-binding site [ion binding] 691437008472 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 691437008473 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 691437008474 motif II; other site 691437008475 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 691437008476 dimerization interface [polypeptide binding]; other site 691437008477 putative DNA binding site [nucleotide binding]; other site 691437008478 putative Zn2+ binding site [ion binding]; other site 691437008479 esterase; Provisional; Region: PRK10566 691437008480 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 691437008481 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 691437008482 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 691437008483 active site 691437008484 motif I; other site 691437008485 motif II; other site 691437008486 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 691437008487 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 691437008488 EDD domain protein, DegV family; Region: DegV; TIGR00762 691437008489 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 691437008490 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 691437008491 Fic family protein [Function unknown]; Region: COG3177 691437008492 Fic/DOC family; Region: Fic; pfam02661 691437008493 Bacteriophage replication protein O; Region: Phage_rep_O; cl04545 691437008494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 691437008495 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 691437008496 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 691437008497 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 691437008498 Walker A/P-loop; other site 691437008499 ATP binding site [chemical binding]; other site 691437008500 Q-loop/lid; other site 691437008501 ABC transporter signature motif; other site 691437008502 Walker B; other site 691437008503 D-loop; other site 691437008504 H-loop/switch region; other site 691437008505 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 691437008506 DinB superfamily; Region: DinB_2; pfam12867 691437008507 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 691437008508 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 691437008509 NAD binding site [chemical binding]; other site 691437008510 substrate binding site [chemical binding]; other site 691437008511 catalytic Zn binding site [ion binding]; other site 691437008512 tetramer interface [polypeptide binding]; other site 691437008513 structural Zn binding site [ion binding]; other site 691437008514 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 691437008515 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 691437008516 NAD(P) binding site [chemical binding]; other site 691437008517 catalytic residues [active] 691437008518 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 691437008519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437008520 active site 691437008521 phosphorylation site [posttranslational modification] 691437008522 intermolecular recognition site; other site 691437008523 dimerization interface [polypeptide binding]; other site 691437008524 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437008525 Walker A motif; other site 691437008526 ATP binding site [chemical binding]; other site 691437008527 Walker B motif; other site 691437008528 arginine finger; other site 691437008529 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 691437008530 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 691437008531 GAF domain; Region: GAF_3; pfam13492 691437008532 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 691437008533 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437008534 dimer interface [polypeptide binding]; other site 691437008535 phosphorylation site [posttranslational modification] 691437008536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437008537 ATP binding site [chemical binding]; other site 691437008538 Mg2+ binding site [ion binding]; other site 691437008539 G-X-G motif; other site 691437008540 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 691437008541 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 691437008542 putative active site [active] 691437008543 metal binding site [ion binding]; metal-binding site 691437008544 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 691437008545 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 691437008546 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 691437008547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437008548 dimer interface [polypeptide binding]; other site 691437008549 conserved gate region; other site 691437008550 putative PBP binding loops; other site 691437008551 ABC-ATPase subunit interface; other site 691437008552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437008553 dimer interface [polypeptide binding]; other site 691437008554 conserved gate region; other site 691437008555 putative PBP binding loops; other site 691437008556 ABC-ATPase subunit interface; other site 691437008557 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 691437008558 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 691437008559 Walker A/P-loop; other site 691437008560 ATP binding site [chemical binding]; other site 691437008561 Q-loop/lid; other site 691437008562 ABC transporter signature motif; other site 691437008563 Walker B; other site 691437008564 D-loop; other site 691437008565 H-loop/switch region; other site 691437008566 TOBE domain; Region: TOBE_2; pfam08402 691437008567 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 691437008568 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 691437008569 Walker A/P-loop; other site 691437008570 ATP binding site [chemical binding]; other site 691437008571 Q-loop/lid; other site 691437008572 ABC transporter signature motif; other site 691437008573 Walker B; other site 691437008574 D-loop; other site 691437008575 H-loop/switch region; other site 691437008576 Integral membrane protein DUF95; Region: DUF95; pfam01944 691437008577 Bacteriocin class IId cyclical uberolysin-like; Region: Bacteriocin_IId; pfam09221 691437008578 S-S bond formation pathway protein; Provisional; Region: PHA02947; cl17416 691437008579 Double zinc ribbon; Region: DZR; pfam12773 691437008580 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 691437008581 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 691437008582 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 691437008583 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 691437008584 FAD binding site [chemical binding]; other site 691437008585 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 691437008586 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 691437008587 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 691437008588 substrate binding pocket [chemical binding]; other site 691437008589 dimer interface [polypeptide binding]; other site 691437008590 inhibitor binding site; inhibition site 691437008591 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 691437008592 B12 binding site [chemical binding]; other site 691437008593 cobalt ligand [ion binding]; other site 691437008594 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 691437008595 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 691437008596 putative active site [active] 691437008597 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 691437008598 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 691437008599 short chain dehydrogenase; Provisional; Region: PRK06701 691437008600 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 691437008601 NAD binding site [chemical binding]; other site 691437008602 metal binding site [ion binding]; metal-binding site 691437008603 active site 691437008604 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 691437008605 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 691437008606 E3 interaction surface; other site 691437008607 lipoyl attachment site [posttranslational modification]; other site 691437008608 e3 binding domain; Region: E3_binding; pfam02817 691437008609 e3 binding domain; Region: E3_binding; pfam02817 691437008610 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 691437008611 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 691437008612 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 691437008613 alpha subunit interface [polypeptide binding]; other site 691437008614 TPP binding site [chemical binding]; other site 691437008615 heterodimer interface [polypeptide binding]; other site 691437008616 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 691437008617 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 691437008618 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 691437008619 tetramer interface [polypeptide binding]; other site 691437008620 TPP-binding site [chemical binding]; other site 691437008621 heterodimer interface [polypeptide binding]; other site 691437008622 phosphorylation loop region [posttranslational modification] 691437008623 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 691437008624 Bacterial transcriptional regulator; Region: IclR; pfam01614 691437008625 PAS domain; Region: PAS; smart00091 691437008626 putative active site [active] 691437008627 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437008628 Walker A motif; other site 691437008629 ATP binding site [chemical binding]; other site 691437008630 Walker B motif; other site 691437008631 arginine finger; other site 691437008632 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 691437008633 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 691437008634 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 691437008635 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 691437008636 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 691437008637 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 691437008638 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 691437008639 hypothetical protein; Validated; Region: PRK06201 691437008640 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 691437008641 PHP domain; Region: PHP; pfam02811 691437008642 Transcriptional regulators [Transcription]; Region: FadR; COG2186 691437008643 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 691437008644 DNA-binding site [nucleotide binding]; DNA binding site 691437008645 FCD domain; Region: FCD; pfam07729 691437008646 N-terminal, non-catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_N_like; cd09013 691437008647 tetramer interface [polypeptide binding]; other site 691437008648 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 691437008649 C-terminal, catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_C_like; cd09014 691437008650 tetramer interface [polypeptide binding]; other site 691437008651 active site 691437008652 metal binding site [ion binding]; metal-binding site 691437008653 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 691437008654 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 691437008655 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 691437008656 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437008657 dimer interface [polypeptide binding]; other site 691437008658 phosphorylation site [posttranslational modification] 691437008659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437008660 ATP binding site [chemical binding]; other site 691437008661 Mg2+ binding site [ion binding]; other site 691437008662 G-X-G motif; other site 691437008663 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 691437008664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437008665 active site 691437008666 phosphorylation site [posttranslational modification] 691437008667 intermolecular recognition site; other site 691437008668 dimerization interface [polypeptide binding]; other site 691437008669 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 691437008670 DNA binding site [nucleotide binding] 691437008671 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 691437008672 FtsX-like permease family; Region: FtsX; pfam02687 691437008673 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 691437008674 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 691437008675 Walker A/P-loop; other site 691437008676 ATP binding site [chemical binding]; other site 691437008677 Q-loop/lid; other site 691437008678 ABC transporter signature motif; other site 691437008679 Walker B; other site 691437008680 D-loop; other site 691437008681 H-loop/switch region; other site 691437008682 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 691437008683 E3 interaction surface; other site 691437008684 lipoyl attachment site [posttranslational modification]; other site 691437008685 HlyD family secretion protein; Region: HlyD_3; pfam13437 691437008686 Transcriptional regulators [Transcription]; Region: PurR; COG1609 691437008687 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 691437008688 DNA binding site [nucleotide binding] 691437008689 domain linker motif; other site 691437008690 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 691437008691 putative dimerization interface [polypeptide binding]; other site 691437008692 putative ligand binding site [chemical binding]; other site 691437008693 trehalose synthase; Region: treS_nterm; TIGR02456 691437008694 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 691437008695 active site 691437008696 catalytic site [active] 691437008697 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 691437008698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437008699 dimer interface [polypeptide binding]; other site 691437008700 conserved gate region; other site 691437008701 putative PBP binding loops; other site 691437008702 ABC-ATPase subunit interface; other site 691437008703 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 691437008704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437008705 dimer interface [polypeptide binding]; other site 691437008706 conserved gate region; other site 691437008707 putative PBP binding loops; other site 691437008708 ABC-ATPase subunit interface; other site 691437008709 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 691437008710 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 691437008711 maltodextrin glucosidase; Provisional; Region: PRK10785 691437008712 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 691437008713 homodimer interface [polypeptide binding]; other site 691437008714 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 691437008715 active site 691437008716 homodimer interface [polypeptide binding]; other site 691437008717 catalytic site [active] 691437008718 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 691437008719 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 691437008720 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 691437008721 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 691437008722 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 691437008723 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 691437008724 active site 691437008725 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 691437008726 dimer interface [polypeptide binding]; other site 691437008727 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 691437008728 Ligand Binding Site [chemical binding]; other site 691437008729 Molecular Tunnel; other site 691437008730 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 691437008731 FIST N domain; Region: FIST; pfam08495 691437008732 FIST C domain; Region: FIST_C; pfam10442 691437008733 PAS domain S-box; Region: sensory_box; TIGR00229 691437008734 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 691437008735 putative active site [active] 691437008736 heme pocket [chemical binding]; other site 691437008737 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 691437008738 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 691437008739 metal binding site [ion binding]; metal-binding site 691437008740 active site 691437008741 I-site; other site 691437008742 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 691437008743 hypothetical protein; Provisional; Region: PRK13673 691437008744 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 691437008745 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 691437008746 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 691437008747 Predicted membrane protein [Function unknown]; Region: COG2311 691437008748 Protein of unknown function (DUF418); Region: DUF418; cl12135 691437008749 Protein of unknown function (DUF418); Region: DUF418; pfam04235 691437008750 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 691437008751 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 691437008752 acyl-activating enzyme (AAE) consensus motif; other site 691437008753 putative active site [active] 691437008754 AMP binding site [chemical binding]; other site 691437008755 putative CoA binding site [chemical binding]; other site 691437008756 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 691437008757 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 691437008758 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 691437008759 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 691437008760 Spore germination protein GerPC; Region: GerPC; pfam10737 691437008761 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 691437008762 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 691437008763 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 691437008764 AAA domain; Region: AAA_23; pfam13476 691437008765 Walker A/P-loop; other site 691437008766 ATP binding site [chemical binding]; other site 691437008767 Q-loop/lid; other site 691437008768 ABC transporter signature motif; other site 691437008769 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 691437008770 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 691437008771 ABC transporter signature motif; other site 691437008772 Walker B; other site 691437008773 D-loop; other site 691437008774 H-loop/switch region; other site 691437008775 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 691437008776 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 691437008777 active site 691437008778 metal binding site [ion binding]; metal-binding site 691437008779 DNA binding site [nucleotide binding] 691437008780 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 691437008781 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 691437008782 Part of AAA domain; Region: AAA_19; pfam13245 691437008783 Family description; Region: UvrD_C_2; pfam13538 691437008784 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 691437008785 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 691437008786 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 691437008787 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 691437008788 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 691437008789 Catalytic site [active] 691437008790 Uncharacterized conserved protein [Function unknown]; Region: COG0398 691437008791 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 691437008792 ComK protein; Region: ComK; pfam06338 691437008793 isocitrate lyase; Provisional; Region: PRK15063 691437008794 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 691437008795 tetramer interface [polypeptide binding]; other site 691437008796 active site 691437008797 Mg2+/Mn2+ binding site [ion binding]; other site 691437008798 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 691437008799 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 691437008800 Cu(I) binding site [ion binding]; other site 691437008801 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 691437008802 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 691437008803 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 691437008804 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 691437008805 homodimer interface [polypeptide binding]; other site 691437008806 substrate-cofactor binding pocket; other site 691437008807 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437008808 catalytic residue [active] 691437008809 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 691437008810 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 691437008811 Walker A/P-loop; other site 691437008812 ATP binding site [chemical binding]; other site 691437008813 Q-loop/lid; other site 691437008814 ABC transporter signature motif; other site 691437008815 Walker B; other site 691437008816 D-loop; other site 691437008817 H-loop/switch region; other site 691437008818 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 691437008819 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 691437008820 TM-ABC transporter signature motif; other site 691437008821 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 691437008822 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 691437008823 zinc binding site [ion binding]; other site 691437008824 putative ligand binding site [chemical binding]; other site 691437008825 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 691437008826 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 691437008827 acyl-activating enzyme (AAE) consensus motif; other site 691437008828 putative AMP binding site [chemical binding]; other site 691437008829 putative active site [active] 691437008830 putative CoA binding site [chemical binding]; other site 691437008831 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 691437008832 YhfH-like protein; Region: YhfH; pfam14149 691437008833 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 691437008834 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 691437008835 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 691437008836 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 691437008837 ferrochelatase; Provisional; Region: PRK12435 691437008838 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 691437008839 C-terminal domain interface [polypeptide binding]; other site 691437008840 active site 691437008841 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 691437008842 active site 691437008843 N-terminal domain interface [polypeptide binding]; other site 691437008844 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 691437008845 substrate binding site [chemical binding]; other site 691437008846 active site 691437008847 Citrate transporter; Region: CitMHS; pfam03600 691437008848 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 691437008849 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 691437008850 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 691437008851 Walker A/P-loop; other site 691437008852 ATP binding site [chemical binding]; other site 691437008853 Q-loop/lid; other site 691437008854 ABC transporter signature motif; other site 691437008855 Walker B; other site 691437008856 D-loop; other site 691437008857 H-loop/switch region; other site 691437008858 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 691437008859 HIT family signature motif; other site 691437008860 catalytic residue [active] 691437008861 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 691437008862 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 691437008863 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 691437008864 transcriptional regulator Hpr; Provisional; Region: PRK13777 691437008865 MarR family; Region: MarR; pfam01047 691437008866 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 691437008867 homodimer interface [polypeptide binding]; other site 691437008868 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 691437008869 substrate-cofactor binding pocket; other site 691437008870 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437008871 catalytic residue [active] 691437008872 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 691437008873 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 691437008874 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 691437008875 generic binding surface II; other site 691437008876 generic binding surface I; other site 691437008877 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 691437008878 Zn2+ binding site [ion binding]; other site 691437008879 Mg2+ binding site [ion binding]; other site 691437008880 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 691437008881 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 691437008882 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 691437008883 Walker A/P-loop; other site 691437008884 ATP binding site [chemical binding]; other site 691437008885 Q-loop/lid; other site 691437008886 ABC transporter signature motif; other site 691437008887 Walker B; other site 691437008888 D-loop; other site 691437008889 H-loop/switch region; other site 691437008890 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 691437008891 YhzD-like protein; Region: YhzD; pfam14120 691437008892 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 691437008893 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 691437008894 FeS/SAM binding site; other site 691437008895 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 691437008896 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 691437008897 active site 691437008898 motif I; other site 691437008899 motif II; other site 691437008900 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 691437008901 hypothetical protein; Provisional; Region: PRK13676 691437008902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 691437008903 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 691437008904 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 691437008905 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 691437008906 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 691437008907 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 691437008908 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 691437008909 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 691437008910 Walker A/P-loop; other site 691437008911 ATP binding site [chemical binding]; other site 691437008912 Q-loop/lid; other site 691437008913 ABC transporter signature motif; other site 691437008914 Walker B; other site 691437008915 D-loop; other site 691437008916 H-loop/switch region; other site 691437008917 TOBE domain; Region: TOBE; pfam03459 691437008918 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 691437008919 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 691437008920 Domain of unknown function DUF21; Region: DUF21; pfam01595 691437008921 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 691437008922 Transporter associated domain; Region: CorC_HlyC; smart01091 691437008923 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 691437008924 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 691437008925 ATP binding site [chemical binding]; other site 691437008926 substrate interface [chemical binding]; other site 691437008927 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 691437008928 ThiS interaction site; other site 691437008929 putative active site [active] 691437008930 tetramer interface [polypeptide binding]; other site 691437008931 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 691437008932 thiS-thiF/thiG interaction site; other site 691437008933 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 691437008934 hydroxyglutarate oxidase; Provisional; Region: PRK11728 691437008935 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 691437008936 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 691437008937 thiamine phosphate binding site [chemical binding]; other site 691437008938 active site 691437008939 pyrophosphate binding site [ion binding]; other site 691437008940 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 691437008941 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 691437008942 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 691437008943 Walker A/P-loop; other site 691437008944 ATP binding site [chemical binding]; other site 691437008945 Q-loop/lid; other site 691437008946 ABC transporter signature motif; other site 691437008947 Walker B; other site 691437008948 D-loop; other site 691437008949 H-loop/switch region; other site 691437008950 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 691437008951 Walker A/P-loop; other site 691437008952 ATP binding site [chemical binding]; other site 691437008953 Q-loop/lid; other site 691437008954 ABC transporter signature motif; other site 691437008955 Walker B; other site 691437008956 D-loop; other site 691437008957 H-loop/switch region; other site 691437008958 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 691437008959 Putative transcription activator [Transcription]; Region: TenA; COG0819 691437008960 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 691437008961 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 691437008962 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 691437008963 putative RNA binding site [nucleotide binding]; other site 691437008964 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437008965 S-adenosylmethionine binding site [chemical binding]; other site 691437008966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437008967 putative transporter; Provisional; Region: PRK12382 691437008968 putative substrate translocation pore; other site 691437008969 metal-dependent hydrolase; Provisional; Region: PRK13291 691437008970 DinB superfamily; Region: DinB_2; pfam12867 691437008971 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 691437008972 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 691437008973 Ca binding site [ion binding]; other site 691437008974 active site 691437008975 catalytic site [active] 691437008976 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 691437008977 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 691437008978 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 691437008979 Protein of unknown function (DUF466); Region: DUF466; pfam04328 691437008980 carbon starvation protein A; Provisional; Region: PRK15015 691437008981 Carbon starvation protein CstA; Region: CstA; pfam02554 691437008982 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 691437008983 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 691437008984 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 691437008985 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 691437008986 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 691437008987 SpoVR like protein; Region: SpoVR; pfam04293 691437008988 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 691437008989 active site 691437008990 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 691437008991 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 691437008992 HAMP domain; Region: HAMP; pfam00672 691437008993 dimerization interface [polypeptide binding]; other site 691437008994 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437008995 dimer interface [polypeptide binding]; other site 691437008996 phosphorylation site [posttranslational modification] 691437008997 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437008998 ATP binding site [chemical binding]; other site 691437008999 Mg2+ binding site [ion binding]; other site 691437009000 G-X-G motif; other site 691437009001 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 691437009002 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 691437009003 YhdB-like protein; Region: YhdB; pfam14148 691437009004 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 691437009005 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 691437009006 active site 691437009007 substrate binding site [chemical binding]; other site 691437009008 metal binding site [ion binding]; metal-binding site 691437009009 FOG: CBS domain [General function prediction only]; Region: COG0517 691437009010 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 691437009011 putative disulfide oxidoreductase; Provisional; Region: PRK03113 691437009012 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 691437009013 catalytic residues [active] 691437009014 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 691437009015 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 691437009016 active site 691437009017 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 691437009018 Domain of unknown function DUF21; Region: DUF21; pfam01595 691437009019 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 691437009020 Transporter associated domain; Region: CorC_HlyC; smart01091 691437009021 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 691437009022 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 691437009023 active site 691437009024 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 691437009025 catalytic tetrad [active] 691437009026 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 691437009027 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 691437009028 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 691437009029 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 691437009030 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 691437009031 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 691437009032 putative active site [active] 691437009033 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437009034 ATP binding site [chemical binding]; other site 691437009035 Mg2+ binding site [ion binding]; other site 691437009036 G-X-G motif; other site 691437009037 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 691437009038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437009039 active site 691437009040 phosphorylation site [posttranslational modification] 691437009041 intermolecular recognition site; other site 691437009042 dimerization interface [polypeptide binding]; other site 691437009043 HTH domain; Region: HTH_11; pfam08279 691437009044 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 691437009045 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 691437009046 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 691437009047 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 691437009048 Putative amidase domain; Region: Amidase_6; pfam12671 691437009049 epoxyqueuosine reductase; Region: TIGR00276 691437009050 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 691437009051 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 691437009052 protein binding surface [polypeptide binding]; other site 691437009053 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 691437009054 B3/4 domain; Region: B3_4; pfam03483 691437009055 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 691437009056 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 691437009057 metal binding site 2 [ion binding]; metal-binding site 691437009058 putative DNA binding helix; other site 691437009059 metal binding site 1 [ion binding]; metal-binding site 691437009060 dimer interface [polypeptide binding]; other site 691437009061 structural Zn2+ binding site [ion binding]; other site 691437009062 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 691437009063 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 691437009064 catalytic triad [active] 691437009065 Ion channel; Region: Ion_trans_2; pfam07885 691437009066 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 691437009067 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 691437009068 tetramer (dimer of dimers) interface [polypeptide binding]; other site 691437009069 NAD binding site [chemical binding]; other site 691437009070 dimer interface [polypeptide binding]; other site 691437009071 substrate binding site [chemical binding]; other site 691437009072 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 691437009073 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 691437009074 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 691437009075 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 691437009076 ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; Region: ABC_NatA_like; cd03267 691437009077 Walker A/P-loop; other site 691437009078 ATP binding site [chemical binding]; other site 691437009079 Q-loop/lid; other site 691437009080 ABC transporter signature motif; other site 691437009081 Walker B; other site 691437009082 D-loop; other site 691437009083 H-loop/switch region; other site 691437009084 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 691437009085 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 691437009086 inhibitor-cofactor binding pocket; inhibition site 691437009087 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437009088 catalytic residue [active] 691437009089 Predicted membrane protein [Function unknown]; Region: COG4129 691437009090 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 691437009091 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 691437009092 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 691437009093 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437009094 dimer interface [polypeptide binding]; other site 691437009095 conserved gate region; other site 691437009096 ABC-ATPase subunit interface; other site 691437009097 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 691437009098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437009099 dimer interface [polypeptide binding]; other site 691437009100 conserved gate region; other site 691437009101 putative PBP binding loops; other site 691437009102 ABC-ATPase subunit interface; other site 691437009103 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 691437009104 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 691437009105 peptide binding site [polypeptide binding]; other site 691437009106 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 691437009107 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 691437009108 Walker A/P-loop; other site 691437009109 ATP binding site [chemical binding]; other site 691437009110 Q-loop/lid; other site 691437009111 ABC transporter signature motif; other site 691437009112 Walker B; other site 691437009113 D-loop; other site 691437009114 H-loop/switch region; other site 691437009115 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 691437009116 hypothetical protein; Provisional; Region: PRK13662 691437009117 YgaB-like protein; Region: YgaB; pfam14182 691437009118 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 691437009119 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 691437009120 putative NAD(P) binding site [chemical binding]; other site 691437009121 active site 691437009122 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 691437009123 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 691437009124 minor groove reading motif; other site 691437009125 helix-hairpin-helix signature motif; other site 691437009126 substrate binding pocket [chemical binding]; other site 691437009127 active site 691437009128 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 691437009129 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 691437009130 DNA binding and oxoG recognition site [nucleotide binding] 691437009131 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 691437009132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437009133 putative substrate translocation pore; other site 691437009134 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 691437009135 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 691437009136 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 691437009137 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 691437009138 catalytic loop [active] 691437009139 iron binding site [ion binding]; other site 691437009140 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 691437009141 4Fe-4S binding domain; Region: Fer4; pfam00037 691437009142 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 691437009143 [4Fe-4S] binding site [ion binding]; other site 691437009144 molybdopterin cofactor binding site; other site 691437009145 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 691437009146 molybdopterin cofactor binding site; other site 691437009147 Uncharacterized conserved protein [Function unknown]; Region: COG2427 691437009148 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 691437009149 acid-soluble spore protein K; Provisional; Region: sspK; PRK03081 691437009150 YpzG-like protein; Region: YpzG; pfam14139 691437009151 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 691437009152 recombination regulator RecX; Provisional; Region: recX; PRK14135 691437009153 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 691437009154 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 691437009155 putative NAD(P) binding site [chemical binding]; other site 691437009156 putative active site [active] 691437009157 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 691437009158 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 691437009159 YfhE-like protein; Region: YfhE; pfam14152 691437009160 YfhD-like protein; Region: YfhD; pfam14151 691437009161 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 691437009162 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 691437009163 Ligand binding site; other site 691437009164 metal-binding site 691437009165 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 691437009166 CoA-transferase family III; Region: CoA_transf_3; pfam02515 691437009167 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 691437009168 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 691437009169 active site 691437009170 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 691437009171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 691437009172 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 691437009173 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 691437009174 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 691437009175 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 691437009176 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 691437009177 Uncharacterized conserved protein [Function unknown]; Region: COG0397 691437009178 hypothetical protein; Validated; Region: PRK00029 691437009179 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 691437009180 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 691437009181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437009182 active site 691437009183 phosphorylation site [posttranslational modification] 691437009184 intermolecular recognition site; other site 691437009185 dimerization interface [polypeptide binding]; other site 691437009186 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 691437009187 DNA binding residues [nucleotide binding] 691437009188 dimerization interface [polypeptide binding]; other site 691437009189 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 691437009190 Histidine kinase; Region: HisKA_3; pfam07730 691437009191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437009192 ATP binding site [chemical binding]; other site 691437009193 Mg2+ binding site [ion binding]; other site 691437009194 G-X-G motif; other site 691437009195 Predicted membrane protein [Function unknown]; Region: COG4758 691437009196 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 691437009197 phage shock protein A; Region: phageshock_pspA; TIGR02977 691437009198 TRAM domain; Region: TRAM; pfam01938 691437009199 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 691437009200 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437009201 S-adenosylmethionine binding site [chemical binding]; other site 691437009202 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 691437009203 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 691437009204 minor groove reading motif; other site 691437009205 helix-hairpin-helix signature motif; other site 691437009206 substrate binding pocket [chemical binding]; other site 691437009207 active site 691437009208 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 691437009209 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 691437009210 NodB motif; other site 691437009211 active site 691437009212 catalytic site [active] 691437009213 Cd binding site [ion binding]; other site 691437009214 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 691437009215 fumarate hydratase FumB; Provisional; Region: PRK15391 691437009216 Fumarase C-terminus; Region: Fumerase_C; pfam05683 691437009217 Radical SAM superfamily; Region: Radical_SAM; pfam04055 691437009218 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 691437009219 FeS/SAM binding site; other site 691437009220 YfkB-like domain; Region: YfkB; pfam08756 691437009221 YfkD-like protein; Region: YfkD; pfam14167 691437009222 calcium/proton exchanger (cax); Region: cax; TIGR00378 691437009223 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 691437009224 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 691437009225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437009226 Major Facilitator Superfamily; Region: MFS_1; pfam07690 691437009227 putative substrate translocation pore; other site 691437009228 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 691437009229 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 691437009230 Low molecular weight phosphatase family; Region: LMWPc; cd00115 691437009231 active site 691437009232 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 691437009233 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 691437009234 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 691437009235 Active Sites [active] 691437009236 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 691437009237 ATP-sulfurylase; Region: ATPS; cd00517 691437009238 active site 691437009239 HXXH motif; other site 691437009240 flexible loop; other site 691437009241 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 691437009242 ligand-binding site [chemical binding]; other site 691437009243 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 691437009244 active site 691437009245 SAM binding site [chemical binding]; other site 691437009246 homodimer interface [polypeptide binding]; other site 691437009247 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 691437009248 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 691437009249 putative active site [active] 691437009250 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 691437009251 putative active site [active] 691437009252 acylphosphatase; Provisional; Region: PRK14420 691437009253 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 691437009254 active site 691437009255 metal binding site [ion binding]; metal-binding site 691437009256 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 691437009257 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 691437009258 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 691437009259 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 691437009260 DDE superfamily endonuclease; Region: DDE_5; cl17874 691437009261 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 691437009262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437009263 H+ Antiporter protein; Region: 2A0121; TIGR00900 691437009264 putative substrate translocation pore; other site 691437009265 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 691437009266 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 691437009267 enolase; Provisional; Region: eno; PRK00077 691437009268 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 691437009269 dimer interface [polypeptide binding]; other site 691437009270 metal binding site [ion binding]; metal-binding site 691437009271 substrate binding pocket [chemical binding]; other site 691437009272 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 691437009273 phosphoglyceromutase; Provisional; Region: PRK05434 691437009274 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 691437009275 triosephosphate isomerase; Provisional; Region: PRK14565 691437009276 substrate binding site [chemical binding]; other site 691437009277 dimer interface [polypeptide binding]; other site 691437009278 catalytic triad [active] 691437009279 Phosphoglycerate kinase; Region: PGK; pfam00162 691437009280 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 691437009281 substrate binding site [chemical binding]; other site 691437009282 hinge regions; other site 691437009283 ADP binding site [chemical binding]; other site 691437009284 catalytic site [active] 691437009285 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 691437009286 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 691437009287 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 691437009288 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 691437009289 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 691437009290 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 691437009291 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 691437009292 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 691437009293 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 691437009294 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 691437009295 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 691437009296 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 691437009297 oligomer interface [polypeptide binding]; other site 691437009298 active site residues [active] 691437009299 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 691437009300 dimerization domain swap beta strand [polypeptide binding]; other site 691437009301 regulatory protein interface [polypeptide binding]; other site 691437009302 active site 691437009303 regulatory phosphorylation site [posttranslational modification]; other site 691437009304 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 691437009305 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 691437009306 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 691437009307 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 691437009308 phosphate binding site [ion binding]; other site 691437009309 putative substrate binding pocket [chemical binding]; other site 691437009310 dimer interface [polypeptide binding]; other site 691437009311 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 691437009312 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 691437009313 putative active site [active] 691437009314 nucleotide binding site [chemical binding]; other site 691437009315 nudix motif; other site 691437009316 putative metal binding site [ion binding]; other site 691437009317 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 691437009318 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 691437009319 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 691437009320 TPR repeat; Region: TPR_11; pfam13414 691437009321 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 691437009322 binding surface 691437009323 TPR motif; other site 691437009324 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 691437009325 binding surface 691437009326 TPR motif; other site 691437009327 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 691437009328 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 691437009329 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 691437009330 metal binding site [ion binding]; metal-binding site 691437009331 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 691437009332 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 691437009333 substrate binding site [chemical binding]; other site 691437009334 glutamase interaction surface [polypeptide binding]; other site 691437009335 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 691437009336 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 691437009337 catalytic residues [active] 691437009338 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 691437009339 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 691437009340 putative active site [active] 691437009341 oxyanion strand; other site 691437009342 catalytic triad [active] 691437009343 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 691437009344 putative active site pocket [active] 691437009345 4-fold oligomerization interface [polypeptide binding]; other site 691437009346 metal binding residues [ion binding]; metal-binding site 691437009347 3-fold/trimer interface [polypeptide binding]; other site 691437009348 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 691437009349 histidinol dehydrogenase; Region: hisD; TIGR00069 691437009350 NAD binding site [chemical binding]; other site 691437009351 dimerization interface [polypeptide binding]; other site 691437009352 product binding site; other site 691437009353 substrate binding site [chemical binding]; other site 691437009354 zinc binding site [ion binding]; other site 691437009355 catalytic residues [active] 691437009356 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 691437009357 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 691437009358 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 691437009359 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 691437009360 dimer interface [polypeptide binding]; other site 691437009361 motif 1; other site 691437009362 active site 691437009363 motif 2; other site 691437009364 motif 3; other site 691437009365 VanZ like family; Region: VanZ; pfam04892 691437009366 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 691437009367 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 691437009368 trimer interface [polypeptide binding]; other site 691437009369 active site 691437009370 substrate binding site [chemical binding]; other site 691437009371 CoA binding site [chemical binding]; other site 691437009372 pyrophosphatase PpaX; Provisional; Region: PRK13288 691437009373 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 691437009374 active site 691437009375 motif I; other site 691437009376 motif II; other site 691437009377 Nucleoside recognition; Region: Gate; pfam07670 691437009378 Nucleoside recognition; Region: Gate; pfam07670 691437009379 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 691437009380 HPr kinase/phosphorylase; Provisional; Region: PRK05428 691437009381 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 691437009382 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 691437009383 Hpr binding site; other site 691437009384 active site 691437009385 homohexamer subunit interaction site [polypeptide binding]; other site 691437009386 Predicted membrane protein [Function unknown]; Region: COG1950 691437009387 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 691437009388 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 691437009389 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 691437009390 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 691437009391 excinuclease ABC subunit B; Provisional; Region: PRK05298 691437009392 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 691437009393 ATP binding site [chemical binding]; other site 691437009394 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 691437009395 nucleotide binding region [chemical binding]; other site 691437009396 ATP-binding site [chemical binding]; other site 691437009397 Ultra-violet resistance protein B; Region: UvrB; pfam12344 691437009398 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; pfam09964 691437009399 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 691437009400 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 691437009401 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 691437009402 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 691437009403 DNA binding residues [nucleotide binding] 691437009404 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 691437009405 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 691437009406 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 691437009407 Ligand binding site; other site 691437009408 Putative Catalytic site; other site 691437009409 DXD motif; other site 691437009410 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 691437009411 C-terminal peptidase (prc); Region: prc; TIGR00225 691437009412 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 691437009413 protein binding site [polypeptide binding]; other site 691437009414 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 691437009415 Catalytic dyad [active] 691437009416 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 691437009417 Pirin-related protein [General function prediction only]; Region: COG1741 691437009418 Pirin; Region: Pirin; pfam02678 691437009419 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 691437009420 YusW-like protein; Region: YusW; pfam14039 691437009421 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 691437009422 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 691437009423 DNA binding residues [nucleotide binding] 691437009424 dimer interface [polypeptide binding]; other site 691437009425 mercury binding site [ion binding]; other site 691437009426 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 691437009427 metal-binding site [ion binding] 691437009428 mercuric reductase; Region: MerA; TIGR02053 691437009429 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 691437009430 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 691437009431 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 691437009432 MerE protein; Region: MerE; cl04911 691437009433 Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654 691437009434 Translation initiation factor eIF3 subunit; Region: eIF3_subunit; pfam08597 691437009435 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 691437009436 Peptidase family M23; Region: Peptidase_M23; pfam01551 691437009437 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 691437009438 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 691437009439 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 691437009440 ATP-binding cassette domain of the cell division transporter; Region: ABC_FtsE_transporter; cd03292 691437009441 Walker A/P-loop; other site 691437009442 ATP binding site [chemical binding]; other site 691437009443 Q-loop/lid; other site 691437009444 ABC transporter signature motif; other site 691437009445 Walker B; other site 691437009446 D-loop; other site 691437009447 H-loop/switch region; other site 691437009448 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 691437009449 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 691437009450 Uncharacterized conserved protein [Function unknown]; Region: COG1284 691437009451 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 691437009452 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 691437009453 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 691437009454 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 691437009455 peptide chain release factor 2; Validated; Region: prfB; PRK00578 691437009456 This domain is found in peptide chain release factors; Region: PCRF; smart00937 691437009457 RF-1 domain; Region: RF-1; pfam00472 691437009458 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 691437009459 DEAD/DEAH box helicase; Region: DEAD; pfam00270 691437009460 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 691437009461 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 691437009462 nucleotide binding region [chemical binding]; other site 691437009463 ATP-binding site [chemical binding]; other site 691437009464 Uncharacterized conserved protein (DUF2036); Region: DUF2036; pfam09724 691437009465 SEC-C motif; Region: SEC-C; pfam02810 691437009466 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 691437009467 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 691437009468 30S subunit binding site; other site 691437009469 Flagellar protein FliT; Region: FliT; pfam05400 691437009470 flagellar protein FliS; Validated; Region: fliS; PRK05685 691437009471 flagellar capping protein; Validated; Region: fliD; PRK07737 691437009472 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 691437009473 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 691437009474 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 691437009475 flagellar protein FlaG; Provisional; Region: PRK07738 691437009476 LAGLIDADG DNA endonuclease family; Region: LAGLIDADG_2; pfam03161 691437009477 flagellin; Reviewed; Region: PRK08869 691437009478 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 691437009479 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 691437009480 carbon storage regulator; Provisional; Region: PRK01712 691437009481 flagellar assembly protein FliW; Provisional; Region: PRK13285 691437009482 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 691437009483 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 691437009484 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 691437009485 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 691437009486 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 691437009487 FlgN protein; Region: FlgN; pfam05130 691437009488 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 691437009489 flagellar operon protein TIGR03826; Region: YvyF 691437009490 Protein of unknown function (DUF327); Region: DUF327; pfam03885 691437009491 flagellin; Provisional; Region: PRK12804 691437009492 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 691437009493 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 691437009494 Flagellar protein FliS; Region: FliS; cl00654 691437009495 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 691437009496 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 691437009497 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 691437009498 active site 691437009499 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 691437009500 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 691437009501 ATP binding site [chemical binding]; other site 691437009502 putative Mg++ binding site [ion binding]; other site 691437009503 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 691437009504 nucleotide binding region [chemical binding]; other site 691437009505 ATP-binding site [chemical binding]; other site 691437009506 EDD domain protein, DegV family; Region: DegV; TIGR00762 691437009507 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 691437009508 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 691437009509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437009510 active site 691437009511 phosphorylation site [posttranslational modification] 691437009512 intermolecular recognition site; other site 691437009513 dimerization interface [polypeptide binding]; other site 691437009514 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 691437009515 DNA binding residues [nucleotide binding] 691437009516 dimerization interface [polypeptide binding]; other site 691437009517 Sensor protein DegS; Region: DegS; pfam05384 691437009518 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 691437009519 Histidine kinase; Region: HisKA_3; pfam07730 691437009520 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437009521 ATP binding site [chemical binding]; other site 691437009522 Mg2+ binding site [ion binding]; other site 691437009523 G-X-G motif; other site 691437009524 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 691437009525 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 691437009526 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 691437009527 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 691437009528 Bacterial SH3 domain; Region: SH3_3; pfam08239 691437009529 Bacterial SH3 domain; Region: SH3_3; pfam08239 691437009530 Bacterial SH3 domain homologues; Region: SH3b; smart00287 691437009531 Bacterial SH3 domain; Region: SH3_3; pfam08239 691437009532 Bacterial SH3 domain; Region: SH3_3; pfam08239 691437009533 Bacterial SH3 domain homologues; Region: SH3b; smart00287 691437009534 Bacterial SH3 domain homologues; Region: SH3b; smart00287 691437009535 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 691437009536 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 691437009537 active site 691437009538 metal binding site [ion binding]; metal-binding site 691437009539 Bacterial SH3 domain; Region: SH3_3; cl17532 691437009540 Bacterial SH3 domain homologues; Region: SH3b; smart00287 691437009541 Stage II sporulation protein; Region: SpoIID; pfam08486 691437009542 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 691437009543 putative glycosyl transferase; Provisional; Region: PRK10307 691437009544 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 691437009545 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 691437009546 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 691437009547 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 691437009548 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 691437009549 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 691437009550 active site 691437009551 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 691437009552 homodimer interface [polypeptide binding]; other site 691437009553 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 691437009554 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 691437009555 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 691437009556 putative trimer interface [polypeptide binding]; other site 691437009557 putative CoA binding site [chemical binding]; other site 691437009558 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 691437009559 putative trimer interface [polypeptide binding]; other site 691437009560 putative active site [active] 691437009561 putative substrate binding site [chemical binding]; other site 691437009562 putative CoA binding site [chemical binding]; other site 691437009563 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 691437009564 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 691437009565 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 691437009566 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 691437009567 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 691437009568 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 691437009569 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 691437009570 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 691437009571 inhibitor-cofactor binding pocket; inhibition site 691437009572 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437009573 catalytic residue [active] 691437009574 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 691437009575 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 691437009576 Mg++ binding site [ion binding]; other site 691437009577 putative catalytic motif [active] 691437009578 substrate binding site [chemical binding]; other site 691437009579 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 691437009580 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 691437009581 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 691437009582 nucleotide binding region [chemical binding]; other site 691437009583 ATP-binding site [chemical binding]; other site 691437009584 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 691437009585 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 691437009586 C-terminal peptidase (prc); Region: prc; TIGR00225 691437009587 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 691437009588 protein binding site [polypeptide binding]; other site 691437009589 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 691437009590 Catalytic dyad [active] 691437009591 Bacterial Ig-like domain; Region: Big_5; pfam13205 691437009592 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 691437009593 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 691437009594 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 691437009595 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 691437009596 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 691437009597 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 691437009598 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 691437009599 homodimer interface [polypeptide binding]; other site 691437009600 maltodextrin glucosidase; Provisional; Region: PRK10785 691437009601 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 691437009602 active site 691437009603 homodimer interface [polypeptide binding]; other site 691437009604 catalytic site [active] 691437009605 Aamy_C domain; Region: Aamy_C; smart00632 691437009606 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 691437009607 Interdomain contacts; other site 691437009608 Cytokine receptor motif; other site 691437009609 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 691437009610 Starch binding domain; Region: CBM_2; smart01065 691437009611 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 691437009612 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 691437009613 active site 691437009614 Na/Ca binding site [ion binding]; other site 691437009615 catalytic site [active] 691437009616 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 691437009617 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 691437009618 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 691437009619 active site 691437009620 metal binding site [ion binding]; metal-binding site 691437009621 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 691437009622 Domain of unknown function (DUF955); Region: DUF955; cl01076 691437009623 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 691437009624 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 691437009625 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 691437009626 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 691437009627 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 691437009628 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 691437009629 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 691437009630 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 691437009631 NlpC/P60 family; Region: NLPC_P60; pfam00877 691437009632 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 691437009633 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 691437009634 non-specific DNA binding site [nucleotide binding]; other site 691437009635 salt bridge; other site 691437009636 sequence-specific DNA binding site [nucleotide binding]; other site 691437009637 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 691437009638 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 691437009639 dimer interface [polypeptide binding]; other site 691437009640 ssDNA binding site [nucleotide binding]; other site 691437009641 tetramer (dimer of dimers) interface [polypeptide binding]; other site 691437009642 YwpF-like protein; Region: YwpF; pfam14183 691437009643 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 691437009644 active site 691437009645 catalytic site [active] 691437009646 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 691437009647 aspartate kinase; Reviewed; Region: PRK09034 691437009648 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 691437009649 putative catalytic residues [active] 691437009650 putative nucleotide binding site [chemical binding]; other site 691437009651 putative aspartate binding site [chemical binding]; other site 691437009652 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 691437009653 allosteric regulatory residue; other site 691437009654 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 691437009655 Protein of unknown function (DUF1284); Region: DUF1284; pfam06935 691437009656 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 691437009657 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 691437009658 NAD(P) binding site [chemical binding]; other site 691437009659 catalytic residues [active] 691437009660 Protein of unknown function (DUF779); Region: DUF779; pfam05610 691437009661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437009662 Major Facilitator Superfamily; Region: MFS_1; pfam07690 691437009663 putative substrate translocation pore; other site 691437009664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437009665 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 691437009666 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 691437009667 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 691437009668 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 691437009669 nucleotide binding site [chemical binding]; other site 691437009670 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 691437009671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437009672 dimer interface [polypeptide binding]; other site 691437009673 conserved gate region; other site 691437009674 putative PBP binding loops; other site 691437009675 ABC-ATPase subunit interface; other site 691437009676 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 691437009677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437009678 dimer interface [polypeptide binding]; other site 691437009679 conserved gate region; other site 691437009680 putative PBP binding loops; other site 691437009681 ABC-ATPase subunit interface; other site 691437009682 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 691437009683 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 691437009684 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 691437009685 Response regulator receiver domain; Region: Response_reg; pfam00072 691437009686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437009687 active site 691437009688 phosphorylation site [posttranslational modification] 691437009689 intermolecular recognition site; other site 691437009690 dimerization interface [polypeptide binding]; other site 691437009691 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 691437009692 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 691437009693 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 691437009694 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 691437009695 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 691437009696 dimerization interface [polypeptide binding]; other site 691437009697 Histidine kinase; Region: His_kinase; pfam06580 691437009698 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437009699 ATP binding site [chemical binding]; other site 691437009700 Mg2+ binding site [ion binding]; other site 691437009701 G-X-G motif; other site 691437009702 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 691437009703 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 691437009704 ligand binding site [chemical binding]; other site 691437009705 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 691437009706 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 691437009707 NAD binding site [chemical binding]; other site 691437009708 sugar binding site [chemical binding]; other site 691437009709 divalent metal binding site [ion binding]; other site 691437009710 tetramer (dimer of dimers) interface [polypeptide binding]; other site 691437009711 dimer interface [polypeptide binding]; other site 691437009712 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 691437009713 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 691437009714 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 691437009715 putative active site [active] 691437009716 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 691437009717 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 691437009718 Walker A/P-loop; other site 691437009719 ATP binding site [chemical binding]; other site 691437009720 Q-loop/lid; other site 691437009721 ABC transporter signature motif; other site 691437009722 Walker B; other site 691437009723 D-loop; other site 691437009724 H-loop/switch region; other site 691437009725 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 691437009726 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 691437009727 FtsX-like permease family; Region: FtsX; pfam02687 691437009728 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 691437009729 active site 691437009730 putative substrate binding region [chemical binding]; other site 691437009731 FAD binding domain; Region: FAD_binding_4; pfam01565 691437009732 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 691437009733 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 691437009734 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 691437009735 alpha subunit interface [polypeptide binding]; other site 691437009736 TPP binding site [chemical binding]; other site 691437009737 heterodimer interface [polypeptide binding]; other site 691437009738 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 691437009739 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 691437009740 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 691437009741 TPP-binding site [chemical binding]; other site 691437009742 tetramer interface [polypeptide binding]; other site 691437009743 heterodimer interface [polypeptide binding]; other site 691437009744 phosphorylation loop region [posttranslational modification] 691437009745 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 691437009746 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 691437009747 E3 interaction surface; other site 691437009748 lipoyl attachment site [posttranslational modification]; other site 691437009749 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 691437009750 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 691437009751 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 691437009752 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 691437009753 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 691437009754 Low molecular weight phosphatase family; Region: LMWPc; cd00115 691437009755 active site 691437009756 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 691437009757 arsenical-resistance protein; Region: acr3; TIGR00832 691437009758 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 691437009759 dimerization interface [polypeptide binding]; other site 691437009760 putative DNA binding site [nucleotide binding]; other site 691437009761 putative Zn2+ binding site [ion binding]; other site 691437009762 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 691437009763 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 691437009764 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 691437009765 ligand binding site [chemical binding]; other site 691437009766 dimerization interface [polypeptide binding]; other site 691437009767 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 691437009768 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 691437009769 TM-ABC transporter signature motif; other site 691437009770 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 691437009771 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 691437009772 Walker A/P-loop; other site 691437009773 ATP binding site [chemical binding]; other site 691437009774 Q-loop/lid; other site 691437009775 ABC transporter signature motif; other site 691437009776 Walker B; other site 691437009777 D-loop; other site 691437009778 H-loop/switch region; other site 691437009779 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 691437009780 D-ribose pyranase; Provisional; Region: PRK11797 691437009781 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 691437009782 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 691437009783 substrate binding site [chemical binding]; other site 691437009784 dimer interface [polypeptide binding]; other site 691437009785 ATP binding site [chemical binding]; other site 691437009786 Transcriptional regulators [Transcription]; Region: PurR; COG1609 691437009787 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 691437009788 DNA binding site [nucleotide binding] 691437009789 domain linker motif; other site 691437009790 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 691437009791 dimerization interface [polypeptide binding]; other site 691437009792 ligand binding site [chemical binding]; other site 691437009793 sodium binding site [ion binding]; other site 691437009794 Predicted integral membrane protein [Function unknown]; Region: COG5652 691437009795 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 691437009796 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 691437009797 metal binding site [ion binding]; metal-binding site 691437009798 dimer interface [polypeptide binding]; other site 691437009799 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 691437009800 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 691437009801 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 691437009802 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 691437009803 Bacterial SH3 domain homologues; Region: SH3b; smart00287 691437009804 Bacterial SH3 domain; Region: SH3_3; pfam08239 691437009805 Bacterial SH3 domain; Region: SH3_3; pfam08239 691437009806 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 691437009807 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 691437009808 active site 691437009809 metal binding site [ion binding]; metal-binding site 691437009810 SEC-C motif; Region: SEC-C; pfam02810 691437009811 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 691437009812 SEC-C motif; Region: SEC-C; pfam02810 691437009813 SEC-C motif; Region: SEC-C; pfam02810 691437009814 SEC-C motif; Region: SEC-C; pfam02810 691437009815 Uncharacterized conserved protein [Function unknown]; Region: COG4715 691437009816 SNF2 Helicase protein; Region: DUF3670; pfam12419 691437009817 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 691437009818 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 691437009819 ATP binding site [chemical binding]; other site 691437009820 putative Mg++ binding site [ion binding]; other site 691437009821 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 691437009822 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 691437009823 nucleotide binding region [chemical binding]; other site 691437009824 ATP-binding site [chemical binding]; other site 691437009825 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 691437009826 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 691437009827 putative ADP-ribose binding site [chemical binding]; other site 691437009828 AAA domain; Region: AAA_21; pfam13304 691437009829 AAA domain; Region: AAA_21; pfam13304 691437009830 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 691437009831 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 691437009832 active site 691437009833 tetramer interface; other site 691437009834 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 691437009835 active site 691437009836 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 691437009837 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 691437009838 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437009839 dimer interface [polypeptide binding]; other site 691437009840 conserved gate region; other site 691437009841 ABC-ATPase subunit interface; other site 691437009842 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 691437009843 EamA-like transporter family; Region: EamA; pfam00892 691437009844 EamA-like transporter family; Region: EamA; pfam00892 691437009845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 691437009846 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 691437009847 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 691437009848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437009849 D-galactonate transporter; Region: 2A0114; TIGR00893 691437009850 putative substrate translocation pore; other site 691437009851 Protein of unknown function DUF262; Region: DUF262; pfam03235 691437009852 Uncharacterized conserved protein [Function unknown]; Region: COG1479 691437009853 Uncharacterized conserved protein [Function unknown]; Region: COG3472 691437009854 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 691437009855 Coenzyme A binding pocket [chemical binding]; other site 691437009856 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 691437009857 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 691437009858 inhibitor-cofactor binding pocket; inhibition site 691437009859 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437009860 catalytic residue [active] 691437009861 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 691437009862 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 691437009863 putative trimer interface [polypeptide binding]; other site 691437009864 putative CoA binding site [chemical binding]; other site 691437009865 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 691437009866 Bacterial sugar transferase; Region: Bac_transf; pfam02397 691437009867 UDP-glucose 4-epimerase; Region: PLN02240 691437009868 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 691437009869 NAD binding site [chemical binding]; other site 691437009870 homodimer interface [polypeptide binding]; other site 691437009871 active site 691437009872 substrate binding site [chemical binding]; other site 691437009873 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 691437009874 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 691437009875 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 691437009876 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 691437009877 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 691437009878 putative NAD(P) binding site [chemical binding]; other site 691437009879 active site 691437009880 putative substrate binding site [chemical binding]; other site 691437009881 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 691437009882 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 691437009883 putative ADP-binding pocket [chemical binding]; other site 691437009884 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 691437009885 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 691437009886 putative ADP-binding pocket [chemical binding]; other site 691437009887 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 691437009888 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 691437009889 putative ADP-binding pocket [chemical binding]; other site 691437009890 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 691437009891 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 691437009892 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 691437009893 Bacterial sugar transferase; Region: Bac_transf; pfam02397 691437009894 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 691437009895 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 691437009896 active site 691437009897 tetramer interface; other site 691437009898 Predicted membrane protein [Function unknown]; Region: COG1511 691437009899 AAA domain; Region: AAA_21; pfam13304 691437009900 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 691437009901 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 691437009902 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 691437009903 active site 691437009904 oxyanion hole [active] 691437009905 catalytic triad [active] 691437009906 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 691437009907 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 691437009908 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 691437009909 Chain length determinant protein; Region: Wzz; cl15801 691437009910 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 691437009911 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 691437009912 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 691437009913 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 691437009914 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 691437009915 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 691437009916 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 691437009917 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 691437009918 rod shape-determining protein Mbl; Provisional; Region: PRK13928 691437009919 MreB and similar proteins; Region: MreB_like; cd10225 691437009920 nucleotide binding site [chemical binding]; other site 691437009921 Mg binding site [ion binding]; other site 691437009922 putative protofilament interaction site [polypeptide binding]; other site 691437009923 RodZ interaction site [polypeptide binding]; other site 691437009924 Stage III sporulation protein D; Region: SpoIIID; pfam12116 691437009925 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 691437009926 Chromate transporter; Region: Chromate_transp; cl17781 691437009927 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 691437009928 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 691437009929 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 691437009930 Peptidase family M23; Region: Peptidase_M23; pfam01551 691437009931 stage II sporulation protein D; Region: spore_II_D; TIGR02870 691437009932 Stage II sporulation protein; Region: SpoIID; pfam08486 691437009933 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 691437009934 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 691437009935 hinge; other site 691437009936 active site 691437009937 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 691437009938 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 691437009939 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 691437009940 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 691437009941 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 691437009942 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 691437009943 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 691437009944 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 691437009945 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 691437009946 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 691437009947 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 691437009948 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 691437009949 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 691437009950 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 691437009951 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 691437009952 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 691437009953 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 691437009954 NADH dehydrogenase subunit C; Validated; Region: PRK07735 691437009955 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 691437009956 NADH dehydrogenase subunit B; Validated; Region: PRK06411 691437009957 NADH dehydrogenase subunit A; Validated; Region: PRK07756 691437009958 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 691437009959 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 691437009960 gamma subunit interface [polypeptide binding]; other site 691437009961 epsilon subunit interface [polypeptide binding]; other site 691437009962 LBP interface [polypeptide binding]; other site 691437009963 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 691437009964 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 691437009965 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 691437009966 alpha subunit interaction interface [polypeptide binding]; other site 691437009967 Walker A motif; other site 691437009968 ATP binding site [chemical binding]; other site 691437009969 Walker B motif; other site 691437009970 inhibitor binding site; inhibition site 691437009971 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 691437009972 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 691437009973 core domain interface [polypeptide binding]; other site 691437009974 delta subunit interface [polypeptide binding]; other site 691437009975 epsilon subunit interface [polypeptide binding]; other site 691437009976 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 691437009977 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 691437009978 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 691437009979 beta subunit interaction interface [polypeptide binding]; other site 691437009980 Walker A motif; other site 691437009981 ATP binding site [chemical binding]; other site 691437009982 Walker B motif; other site 691437009983 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 691437009984 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 691437009985 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 691437009986 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 691437009987 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 691437009988 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 691437009989 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 691437009990 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 691437009991 ATP synthase I chain; Region: ATP_synt_I; cl09170 691437009992 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 691437009993 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 691437009994 active site 691437009995 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 691437009996 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 691437009997 dimer interface [polypeptide binding]; other site 691437009998 active site 691437009999 glycine-pyridoxal phosphate binding site [chemical binding]; other site 691437010000 folate binding site [chemical binding]; other site 691437010001 hypothetical protein; Provisional; Region: PRK13690 691437010002 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 691437010003 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 691437010004 dimerization interface [polypeptide binding]; other site 691437010005 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 691437010006 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 691437010007 dimer interface [polypeptide binding]; other site 691437010008 putative CheW interface [polypeptide binding]; other site 691437010009 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 691437010010 Low molecular weight phosphatase family; Region: LMWPc; cd00115 691437010011 active site 691437010012 Predicted membrane protein [Function unknown]; Region: COG1971 691437010013 Domain of unknown function DUF; Region: DUF204; pfam02659 691437010014 Domain of unknown function DUF; Region: DUF204; pfam02659 691437010015 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 691437010016 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 691437010017 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 691437010018 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 691437010019 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437010020 S-adenosylmethionine binding site [chemical binding]; other site 691437010021 peptide chain release factor 1; Validated; Region: prfA; PRK00591 691437010022 This domain is found in peptide chain release factors; Region: PCRF; smart00937 691437010023 RF-1 domain; Region: RF-1; pfam00472 691437010024 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 691437010025 thymidine kinase; Provisional; Region: PRK04296 691437010026 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 691437010027 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 691437010028 transcription termination factor Rho; Provisional; Region: rho; PRK09376 691437010029 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 691437010030 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 691437010031 RNA binding site [nucleotide binding]; other site 691437010032 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 691437010033 multimer interface [polypeptide binding]; other site 691437010034 Walker A motif; other site 691437010035 ATP binding site [chemical binding]; other site 691437010036 Walker B motif; other site 691437010037 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 691437010038 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 691437010039 putative active site [active] 691437010040 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 691437010041 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 691437010042 hinge; other site 691437010043 active site 691437010044 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 691437010045 active site 691437010046 intersubunit interactions; other site 691437010047 catalytic residue [active] 691437010048 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 691437010049 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 691437010050 intersubunit interface [polypeptide binding]; other site 691437010051 active site 691437010052 zinc binding site [ion binding]; other site 691437010053 Na+ binding site [ion binding]; other site 691437010054 Response regulator receiver domain; Region: Response_reg; pfam00072 691437010055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437010056 active site 691437010057 phosphorylation site [posttranslational modification] 691437010058 intermolecular recognition site; other site 691437010059 dimerization interface [polypeptide binding]; other site 691437010060 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 691437010061 CTP synthetase; Validated; Region: pyrG; PRK05380 691437010062 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 691437010063 Catalytic site [active] 691437010064 active site 691437010065 UTP binding site [chemical binding]; other site 691437010066 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 691437010067 active site 691437010068 putative oxyanion hole; other site 691437010069 catalytic triad [active] 691437010070 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 691437010071 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 691437010072 B12 binding site [chemical binding]; other site 691437010073 cobalt ligand [ion binding]; other site 691437010074 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 691437010075 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 691437010076 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, unknown subfamily 1; composed of uncharacterized bacterial proteins containing a C-terminal MCM domain. MCM catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA. The...; Region: MM_CoA_mutase_1; cd03678 691437010077 putative active site [active] 691437010078 putative substrate binding site [chemical binding]; other site 691437010079 putative coenzyme B12 binding site [chemical binding]; other site 691437010080 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 691437010081 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 691437010082 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 691437010083 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 691437010084 FAD binding site [chemical binding]; other site 691437010085 homotetramer interface [polypeptide binding]; other site 691437010086 substrate binding pocket [chemical binding]; other site 691437010087 catalytic base [active] 691437010088 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 691437010089 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 691437010090 FAD binding site [chemical binding]; other site 691437010091 homotetramer interface [polypeptide binding]; other site 691437010092 substrate binding pocket [chemical binding]; other site 691437010093 catalytic base [active] 691437010094 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 691437010095 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 691437010096 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 691437010097 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 691437010098 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 691437010099 dimer interface [polypeptide binding]; other site 691437010100 active site 691437010101 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 691437010102 4Fe-4S binding domain; Region: Fer4; cl02805 691437010103 Cysteine-rich domain; Region: CCG; pfam02754 691437010104 Cysteine-rich domain; Region: CCG; pfam02754 691437010105 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 691437010106 PLD-like domain; Region: PLDc_2; pfam13091 691437010107 putative active site [active] 691437010108 catalytic site [active] 691437010109 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 691437010110 PLD-like domain; Region: PLDc_2; pfam13091 691437010111 putative active site [active] 691437010112 catalytic site [active] 691437010113 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 691437010114 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 691437010115 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 691437010116 active site 691437010117 HIGH motif; other site 691437010118 KMSK motif region; other site 691437010119 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 691437010120 tRNA binding surface [nucleotide binding]; other site 691437010121 anticodon binding site; other site 691437010122 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 691437010123 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 691437010124 agmatinase; Region: agmatinase; TIGR01230 691437010125 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 691437010126 putative active site [active] 691437010127 Mn binding site [ion binding]; other site 691437010128 spermidine synthase; Provisional; Region: PRK00811 691437010129 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437010130 Transglycosylase; Region: Transgly; pfam00912 691437010131 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 691437010132 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 691437010133 YwhD family; Region: YwhD; pfam08741 691437010134 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 691437010135 Peptidase family M50; Region: Peptidase_M50; pfam02163 691437010136 active site 691437010137 putative substrate binding region [chemical binding]; other site 691437010138 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 691437010139 active site 1 [active] 691437010140 dimer interface [polypeptide binding]; other site 691437010141 hexamer interface [polypeptide binding]; other site 691437010142 active site 2 [active] 691437010143 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 691437010144 Uncharacterized conserved protein [Function unknown]; Region: COG3465 691437010145 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 691437010146 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 691437010147 Zn2+ binding site [ion binding]; other site 691437010148 Mg2+ binding site [ion binding]; other site 691437010149 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 691437010150 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 691437010151 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 691437010152 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 691437010153 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 691437010154 putative heme peroxidase; Provisional; Region: PRK12276 691437010155 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 691437010156 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 691437010157 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 691437010158 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 691437010159 ligand binding site [chemical binding]; other site 691437010160 active site 691437010161 UGI interface [polypeptide binding]; other site 691437010162 catalytic site [active] 691437010163 Uncharacterized conserved protein [Function unknown]; Region: COG3339 691437010164 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 691437010165 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 691437010166 anti sigma factor interaction site; other site 691437010167 regulatory phosphorylation site [posttranslational modification]; other site 691437010168 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 691437010169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437010170 ATP binding site [chemical binding]; other site 691437010171 Mg2+ binding site [ion binding]; other site 691437010172 G-X-G motif; other site 691437010173 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 691437010174 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 691437010175 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 691437010176 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 691437010177 DNA binding residues [nucleotide binding] 691437010178 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 691437010179 PAS domain; Region: PAS_9; pfam13426 691437010180 putative active site [active] 691437010181 heme pocket [chemical binding]; other site 691437010182 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 691437010183 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 691437010184 PemK-like protein; Region: PemK; pfam02452 691437010185 azoreductase; Reviewed; Region: PRK00170 691437010186 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 691437010187 glycyl-tRNA synthetase; Provisional; Region: PRK04173 691437010188 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 691437010189 motif 1; other site 691437010190 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 691437010191 active site 691437010192 motif 2; other site 691437010193 motif 3; other site 691437010194 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 691437010195 anticodon binding site; other site 691437010196 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 691437010197 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 691437010198 active site 691437010199 benzoate transport; Region: 2A0115; TIGR00895 691437010200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437010201 putative substrate translocation pore; other site 691437010202 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 691437010203 Transposase; Region: HTH_Tnp_1; cl17663 691437010204 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 691437010205 HPr interaction site; other site 691437010206 glycerol kinase (GK) interaction site [polypeptide binding]; other site 691437010207 active site 691437010208 phosphorylation site [posttranslational modification] 691437010209 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 691437010210 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 691437010211 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 691437010212 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 691437010213 hexamer interface [polypeptide binding]; other site 691437010214 ligand binding site [chemical binding]; other site 691437010215 putative active site [active] 691437010216 NAD(P) binding site [chemical binding]; other site 691437010217 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 691437010218 putative active site [active] 691437010219 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 691437010220 dimer interface [polypeptide binding]; other site 691437010221 substrate binding site [chemical binding]; other site 691437010222 ATP binding site [chemical binding]; other site 691437010223 Predicted amidohydrolase [General function prediction only]; Region: COG0388 691437010224 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 691437010225 putative active site [active] 691437010226 catalytic triad [active] 691437010227 putative dimer interface [polypeptide binding]; other site 691437010228 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 691437010229 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 691437010230 Na binding site [ion binding]; other site 691437010231 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 691437010232 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 691437010233 substrate binding pocket [chemical binding]; other site 691437010234 membrane-bound complex binding site; other site 691437010235 hinge residues; other site 691437010236 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 691437010237 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 691437010238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437010239 dimer interface [polypeptide binding]; other site 691437010240 conserved gate region; other site 691437010241 putative PBP binding loops; other site 691437010242 ABC-ATPase subunit interface; other site 691437010243 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 691437010244 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 691437010245 Walker A/P-loop; other site 691437010246 ATP binding site [chemical binding]; other site 691437010247 Q-loop/lid; other site 691437010248 ABC transporter signature motif; other site 691437010249 Walker B; other site 691437010250 D-loop; other site 691437010251 H-loop/switch region; other site 691437010252 Probable transposase; Region: OrfB_IS605; pfam01385 691437010253 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 691437010254 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 691437010255 Transposase IS200 like; Region: Y1_Tnp; pfam01797 691437010256 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 691437010257 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 691437010258 Subunit I/III interface [polypeptide binding]; other site 691437010259 Subunit III/IV interface [polypeptide binding]; other site 691437010260 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 691437010261 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 691437010262 D-pathway; other site 691437010263 Putative ubiquinol binding site [chemical binding]; other site 691437010264 Low-spin heme (heme b) binding site [chemical binding]; other site 691437010265 Putative water exit pathway; other site 691437010266 Binuclear center (heme o3/CuB) [ion binding]; other site 691437010267 K-pathway; other site 691437010268 Putative proton exit pathway; other site 691437010269 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 691437010270 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 691437010271 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 691437010272 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 691437010273 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 691437010274 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 691437010275 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 691437010276 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 691437010277 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 691437010278 [2Fe-2S] cluster binding site [ion binding]; other site 691437010279 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 691437010280 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 691437010281 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 691437010282 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 691437010283 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 691437010284 metal binding site [ion binding]; metal-binding site 691437010285 active site 691437010286 I-site; other site 691437010287 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 691437010288 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 691437010289 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 691437010290 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 691437010291 protein binding site [polypeptide binding]; other site 691437010292 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 691437010293 YycH protein; Region: YycI; pfam09648 691437010294 YycH protein; Region: YycH; pfam07435 691437010295 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 691437010296 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 691437010297 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 691437010298 dimerization interface [polypeptide binding]; other site 691437010299 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 691437010300 putative active site [active] 691437010301 heme pocket [chemical binding]; other site 691437010302 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437010303 dimer interface [polypeptide binding]; other site 691437010304 phosphorylation site [posttranslational modification] 691437010305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437010306 ATP binding site [chemical binding]; other site 691437010307 Mg2+ binding site [ion binding]; other site 691437010308 G-X-G motif; other site 691437010309 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 691437010310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437010311 active site 691437010312 phosphorylation site [posttranslational modification] 691437010313 intermolecular recognition site; other site 691437010314 dimerization interface [polypeptide binding]; other site 691437010315 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 691437010316 DNA binding site [nucleotide binding] 691437010317 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 691437010318 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 691437010319 GDP-binding site [chemical binding]; other site 691437010320 ACT binding site; other site 691437010321 IMP binding site; other site 691437010322 replicative DNA helicase; Provisional; Region: PRK05748 691437010323 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 691437010324 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 691437010325 Walker A motif; other site 691437010326 ATP binding site [chemical binding]; other site 691437010327 Walker B motif; other site 691437010328 DNA binding loops [nucleotide binding] 691437010329 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 691437010330 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 691437010331 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 691437010332 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 691437010333 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 691437010334 DHH family; Region: DHH; pfam01368 691437010335 DHHA1 domain; Region: DHHA1; pfam02272 691437010336 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 691437010337 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 691437010338 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 691437010339 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 691437010340 dimer interface [polypeptide binding]; other site 691437010341 ssDNA binding site [nucleotide binding]; other site 691437010342 tetramer (dimer of dimers) interface [polypeptide binding]; other site 691437010343 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 691437010344 GTP-binding protein YchF; Reviewed; Region: PRK09601 691437010345 YchF GTPase; Region: YchF; cd01900 691437010346 G1 box; other site 691437010347 GTP/Mg2+ binding site [chemical binding]; other site 691437010348 Switch I region; other site 691437010349 G2 box; other site 691437010350 Switch II region; other site 691437010351 G3 box; other site 691437010352 G4 box; other site 691437010353 G5 box; other site 691437010354 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 691437010355 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 691437010356 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 691437010357 putative [4Fe-4S] binding site [ion binding]; other site 691437010358 putative molybdopterin cofactor binding site [chemical binding]; other site 691437010359 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 691437010360 molybdopterin cofactor binding site; other site 691437010361 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 691437010362 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 691437010363 Mechanosensitive ion channel; Region: MS_channel; pfam00924 691437010364 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 691437010365 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 691437010366 ParB-like nuclease domain; Region: ParB; smart00470 691437010367 KorB domain; Region: KorB; pfam08535 691437010368 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 691437010369 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 691437010370 P-loop; other site 691437010371 Magnesium ion binding site [ion binding]; other site 691437010372 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 691437010373 Magnesium ion binding site [ion binding]; other site 691437010374 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 691437010375 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 691437010376 ParB-like nuclease domain; Region: ParBc; pfam02195 691437010377 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 691437010378 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 691437010379 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 691437010380 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 691437010381 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 691437010382 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 691437010383 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 691437010384 trmE is a tRNA modification GTPase; Region: trmE; cd04164 691437010385 G1 box; other site 691437010386 GTP/Mg2+ binding site [chemical binding]; other site 691437010387 Switch I region; other site 691437010388 G2 box; other site 691437010389 Switch II region; other site 691437010390 G3 box; other site 691437010391 G4 box; other site 691437010392 G5 box; other site 691437010393 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 691437010394 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 691437010395 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 691437010396 G-X-X-G motif; other site 691437010397 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 691437010398 RxxxH motif; other site 691437010399 OxaA-like protein precursor; Validated; Region: PRK02944 691437010400 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 691437010401 ribonuclease P; Reviewed; Region: rnpA; PRK00499 691437010402 Ribosomal protein L34; Region: Ribosomal_L34; cl00370